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Materials Science and Engineering C

Actualizaciones al 14 de Octubre
Modeling of a biological material nacre: Waviness stiffness model
N.S. Al-Maskari, D.A. McAdams, J.N. Reddy
Nacre is a tough yet stiff natural composite composed of microscopic mineral polygonal
tablets bonded by a tough biopolymer. The high stiffness of nacre is known to be due to its
high mineral content. However, the remarkable toughness of nacre is explained by its
ability to deform past a yield point and develop large inelastic strain over a large volume
around defects and cracks. The high strain is mainly due to sliding and waviness of the
tablets. Mimicking nacre's remarkable properties, to date, is still a challenge due in part to
fabrication challenges as well as a lack of models that can predict its properties or
properties of a bulk material given specific constituent materials and material structure.
Previous attempts to create analytical models for nacre include tablet sliding but don't
account for the waviness of the tablets. In this work, a mathematical model is proposed to
account for the waviness of the tablet. Using this model, a better prediction of the elastic
modulus is obtained that agrees with experimental values found in the literature. In
addition, the waviness angle can be predicted which is within the recommended range.
Having a good representative model aids in designing a bio-mimicked nacre.
Enhanced antimicrobial activities of silver-nanoparticle-decorated
graphene nanocomposites against oral pathogens


Jian-min Peng, Jia-cheng Lin, Zhuo-yu Chen, Meng-chao Wei, Yuan-xiang Fu, Shu-shen
Lu, Dong-sheng Yu, Wei Zhao
As a means of capitalizing on the synergistic properties between reduced graphene
nanosheets (R-GNs) and silver nanoparticles (AgNPs), an efficient and convenient
chemical reduction method was used to prepare silver-nanoparticle-decorated reduced
graphene nanocomposites (R-GNs/Ag). Their antimicrobial activities against oral
pathogens such as Candida albicans, Lactobacillus acidophilus, Streptococcu mutans
and Aggregatibacter actinomycetemcomitans were investigated by MIC determination, the
counting of colony-forming units (CFU), agar diffusion tests, and growth curve observation.
Compared with pure R-GNs and AgNPs, R-GNs/Ag composites exhibited enhanced
antimicrobial properties owing to highly dispersed AgNPs on R-GNs.

PLGA nano/microparticles loaded with cresyl violet as a tracer for drug delivery:
Characterization and in-situ hyperspectral fluorescence and 2-photon localization
Claure N. Lunardi, Anderson J. Gomes, Sandeep Palepu, P. Thilanka Galwaduge,
Elizabeth M.C. Hillman
PLGA Particles were prepared using a cosolvent method, after which the physicochemical
properties such as morphology, particle size, drug entrapment efficiency, drug loading and
in vitro drug release behavior were measured in addition to spectroscopic properties, such
as absorption, fluorescence and infrared spectra. The particles were then tested in an in
vivo mouse model to assess their biodistribution characteristics. The location and integrity
of particles after injection was determined using both hyperspectral fluorescence and twophoton microscopy within intact organs in situ. The results show that cresyl violet is
efficiently entrapped into PLGA particles, and that the particles are spherical in shape,
ranging from 300 to 5070 nm in diameter. Particle biodistribution in the mouse was found
to depend on particle size, as expected. Cresyl violet is shown to be an ideal tracer to
assess the properties PLGA particle-based drug delivery in combination with our novel
multi-scale optical imaging techniques for in-situ particle localization.