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. Mass drug administration reduces the transmission of filarial infection and disease morbidity by decreasing the burden of microfilaremia. Chief Editor: Pranatharthi Haran Chandrasekar. Log out Cancel Filariasis Treatment & Management Author: Siddharth Wayangankar. Pharma. 49] For example. MPH. 45. you will be required to enter your username and password the next time you visit.. MD more.. 2015 Approach Considerations The medical management of a filarial infection should be specific and based on the microfilariae isolated or antigenemia detected. 47. Updated: Dec 10. MBBS. MD. 46. 48. 16/10/2016 20:43 .medscape. 5 of 11 http://emedicine. Since this species has no alternative hosts..[44. annual mass treatment with albendazole and ivermectin is employed to interrupt the transmission of W bancrofti.Filariasis Treatment & Management: Approach Considerations.com/article/217776-treatment#d10 No Results News & Perspective Drugs & Diseases CME & Education close Please confirm that you would like to log out of Medscape. resulting in suboptimal levels for transmission by disease vectors. If you log out.

apply antiseptic creams to abrasions. One study evaluated the effect of higher dose and increased frequency (twice yearly) of albendazole-ivermectin therapy for W bancrofti and found that it resulted in complete microfilarial clearance. 6 of 11 http://emedicine. In addition. Such care includes the use of antihistamines. Onchocerciasis Nodulectomy with local anesthetic is a common treatment to reduce skin and eye complications. inpatient care is recommended to monitor for reactions and complications of therapy. steroids. Onchocerciasis If DEC and suramin (currently the only drug in clinical use for onchocerciasis that is effective against adult worms) are used.[51. but visitors to these regions should use insect repellent and mosquito nets.[56] Bed rest.[55] Surgery Lymphatic filariasis Large hydroceles and scrotal elephantiasis can be managed with surgical excision.[50] The effects of mass treatment on filariasis have reportedly been sustained for up to 6 years. Individuals with chronic infections should wash the affected area frequently. However. limb elevation. Mild to moderate filarial lymphedema has been shown to improve with a 6-week course of doxycycline. pain relief. keep their nails clean. Consultations To prevent inappropriate treatment.medscape.com/article/217776-treatment#d10 this approach could theoretically result in eventual eradication of bancroftian filariasis. and compression bandages traditionally have been used for the management of chronic lymphedema. 52. 54] No filariasis vaccine is currently available. Chronic filariasis Treatment of chronic filariasis does not change the prognosis. Other possible consultations include: Urologist Ophthalmologist General surgeon Plastic surgeon Pharmacologic Therapy Lymphatic filariasis Patients with asymptomatic microfilaremia can be treated on an outpatient basis. Secondary infection Supportive care should include the prevention of secondary infection. Pharma. Supervision of oral DEC therapy and provocation with postadministration observation is recommended for patient compliance with therapy and for the management of febrile reactions in heavily infected patients. the sclerosing action conferred by diagnostic lymphangiography may plug the leak.[28] 16/10/2016 20:43 . consult an infectious disease specialist in all cases of suspected filariasis outside of endemic nations.Filariasis Treatment & Management: Approach Considerations.[31] Inpatient care may initially be required for adenolymphangitis (ADL) and chronic filariasis. but efforts to develop an effective one are under way. still typically undergo treatment. hoping to diminish progression of the disease. and intravenous antibiotics for secondary infections.. Diet and activity Fatty foods are restricted in individuals with proven chyluria that is associated with lymphatic filariasis. and exercise the affected limb to aid lymphatic flow. as well as a more sustained clearance than that resulting from standard-dose albendazole-ivermectin treatment. independent of ongoing infection. especially in patients with advanced disease. asymptomatic patients.[57] Chyluria In the treatment of chyluria. Correcting gross limb elephantiasis with surgery is less successful and may necessitate multiple procedures and skin grafting.. Individuals with chronic lymphatic filariasis are encouraged to mobilize (with compression bandage support) the affected limb. wear comfortable footwear. a special low-fat. 53. as irreversible fibrosis usually destroys lymphatic tissue. although the benefit of this is unclear. Prevention Avoidance of bites from insect vectors is usually not feasible for residents of endemic areas. Lymphedema Steroids can be used to soften and reduce the swelling of lymphedematous tissues. high-protein diet supplemented with medium-chain triglycerides may prove beneficial.

After treatment. Stewart G Wolf Endowed Chair in Internal Medicine. American Society for Microbiology.Filariasis Treatment & Management: Approach Considerations. MD David Ross Boyd Professor and Chairman. MBBS. Pharma. patients should be monitored for symptoms that are characteristic of parasitic infections. M perstans remained suppressed in 75% of patients who had received doxycycline.[69] Long-Term Monitoring Patient monitoring includes posttreatment follow-up for 12 months. Medicine Service. an endosymbiont found in most filarial species. 59.. MD is a member of the following medical societies: American College of Physicians. antigenemia. Fellow. 60. Infectious Diseases Society of America Disclosure: Nothing to disclose. 66. 67] M perstans infection Because M perstans is resistant to standard antiparasitic treatment. Coauthor(s) Michael Stuart Bronze. Internal Medicine Residency Program. Oklahoma University Health Sciences Center Siddharth Wayangankar. MD Medical Officer. Observe and monitor oral therapeutic plans with DEC because compliance with therapy is poor and usually incomplete. In the United States. doxycycline is sometimes used to eradicate Wolbachia. at risk for other parasitic infections because areas endemic for bancroftian filariasis are also endemic for other parasites. University of Oklahoma Health Science Center. American Medical Association. Patients were randomly assigned to receive 200 mg of doxycycline orally every day for 6 weeks or no treatment. Division of Special Pathogens 16/10/2016 20:43 . a 3-week course of doxycycline followed by a single dose of DEC was shown to be microfilaricidal. with examination of peripheral blood and skin snips for microfilariae. 97% of patients who received doxycycline had no detectable blood levels of M perstans. Program Director of Infectious Disease Fellowship. Department of Medicine. The addition of albendazole seems to improve response. At 36 months. Oklahoma State Medical Association.[26. Department of Internal Medicine. Department of Internal Medicine. Bancroftian filariasis Ivermectin is now considered the drug of choice for the treatment of bancroftian filariasis. Coulibaly et al recruited patients with M perstans infection from 4 African villages in Mali. MBBS. it can be obtained from the Centers for Disease Control and Prevention (CDC). Patients with filariasis are. Assistant Chief.[69] At 12 months. MD is a member of the following medical societies: Alpha Omega Alpha. Department of Medicine. Infectious Diseases Society of America Disclosure: Nothing to disclose. Department of Medicine. and clinical manifestations.[58. in endemic areas of the world. Master of the American College of Physicians.[50. Southern Society for Clinical Investigation. This agent may shorten the number of annual treatments to 6. Director. 61] Six-week and 8-week courses of doxycycline have compared favorably with ivermectin plus albendazole. International Immunocompromised Host Society. 64. MD Associate Professor and Vice Chair for Education. Association of Professors of Medicine. MD is a member of the following medical societies: American College of Physicians-American Society of Internal Medicine. it is provided free by the Mectizan Donation Program. Chief Editor Pranatharthi Haran Chandrasekar.[62] Doxycycline therapy may be more readily available and may be better tolerated by some patients. It may also be capable of preventing or reversing lymphatic pathology. randomized trial. Infectious Diseases and Pediatrics. MPH is a member of the following medical societies: American College of Physicians Disclosure: Nothing to disclose. Medication Contributor Information and Disclosures Author Siddharth Wayangankar. MD Professor. American College of Physicians. MD. Infectious Diseases Society of America Michael Stuart Bronze. Acknowledgements Rosemary Johann-Liang. compared with 16% of patients in the group that did not receive treatment.[63] Findings have validated the use of single-dose regimens of ivermectin and DEC or albendazole for large-scale control and eradication programs aimed at reducing Wuchereria bancrofti microfilaremia. Rhett L Jackson. 65. American Medical Association Disclosure: Nothing to disclose. University of Oklahoma College of Medicine. 68] Doxycycline treatment typically kills or sterilizes the filarial nematode.medscape. by default..[63] In one study. Wayne State University School of Medicine Pranatharthi Haran Chandrasekar.com/article/217776-treatment#d10 Moxidectin is being investigated as an alternative to ivermectin for the treatment of river blindness. Oklahoma City Veterans Affairs Hospital Rhett L Jackson. 7 of 11 http://emedicine. In an open-label. Chief of Infectious Disease. MD. MPH Resident Physician.

American Public Health Association. [Medline]. Charles S Levy. Director of Infectious Diseases and Unit Head of Queensland Paediatric Infectious Laboratory. 6. Hatz C. Department of Medicine. 2012 Mar 29. 7. [Medline]. Prevalence of endemic Bancroftian filariasis in the high altitude region of south-eastern Nigeria. Editor-in-Chief. Garred P. Thomas M Kerkering. Uttah EC. Infectious Diseases Society of America. Department of Pediatrics. University of Nebraska Medical Center College of Pharmacy. and Pediatric Infectious Diseases Society Disclosure: Nothing to disclose. Leconte F. 2. American Pediatric Society. Pediatric Infectious Diseases Society. Infect Dis Clin North Am. American Society of Tropical Medicine and Hygiene. 4. 8 of 11 http://emedicine. Associate Professor. George Washington University School of Medicine Charles S Levy. Editor-in-Chief. [Medline]. Department of Parasitology. 84(6):988-93. Simonsen PE. Department of Pediatrics. Royal Children's Hospital Disclosure: Nothing to disclose. Division of Pediatric Infectious Diseases. American College of Physicians. Tulane University School of Medicine Russell W Steele. Meyrowitsch DW.. and Southern Medical Association Disclosure: Nothing to disclose. Drexel University College of Medicine Robert W Tolan Jr. Medical Society of Virginia. Louis-Charles J. Mary L Windle. Nematode infections: filariases. Section of Infectious Disease. Infectious Diseases Society of America. Society for Pediatric Research. Senior Lecturer. 366(13):1169-71. Australia Disclosure: Nothing to disclose. Otogbe FK. Westmead. PhD Head. FRACP. The Children's Hospital at Saint Peter's University Hospital. American Society for Microbiology. 2011 Jun. MD Head. 16/10/2016 20:43 . Knopp S. American Society of Tropical Medicine and Hygiene. Okon OE. 2010 Jan. Alifrangis M. and Physicians for Social Responsibility Disclosure: Novartis Honoraria Speaking and teaching John Charles Walker. 2012 Jun. Utzinger J. Bancroftian filariasis among the Mbembe people of Cross River state. MSc. PhD Adjunct Assistant Professor. Association between mannose-binding lectin polymorphisms and Wuchereria bancrofti infection in two communities in NorthEastern Tanzania. et al. MD Associate Professor. Addiss DG. Francisco Talavera. Louisiana State Medical Society. West Virginia University Martin Weisse. MD is a member of the following medical societies: American Academy of Pediatrics. 26(2):359-81. [Medline]. Roberts J. 2010 Jun. Opara KN. MD is a member of the following medical societies: American Academy of Pediatrics. MBBS. American Academy of Pediatrics. and Medical Society of the District of Columbia Disclosure: Nothing to disclose. Martin Weisse. and Infectious Diseases Society of America Disclosure: Nothing to disclose. PLoS Negl Trop Dis. J Vector Borne Dis. Clinical Professor. Iboh CI. 3. Virginia Tech Carilion School of Medicine Thomas M Kerkering. 2011 Jun. Feasibility and effectiveness of basic lymphedema management in Leogane. Molyneux DH. Department of Medicine.com/article/217776-treatment#d10 and Immunological Drug Products. Russell W Steele. Am J Trop Med Hyg. References 1. 47(2):91-6. MD is a member of the following medical societies: Alpha Omega Alpha. FRCPA Associate Professor in Biomolecular. Michael D Nissen. Center for Drug Evaluation and Research. PharmD Adjunct Associate Professor. Medscape Drug Reference Disclosure: Nothing to disclose. Infectious Diseases Society of America. Australia. 82(1):115-20. American Society for Microbiology. Wendt JM. Biomedical Science & Health. [Medline]. Clinical Associate Professor of Pediatrics. Sodahlon YK. N Engl J Med. American Medical Association. J Vector Borne Dis. MD Chief of Infectious Diseases. MD Chief. Food and Drug Administration Rosemary Johann-Liang. 48(2):78-84. Center for Infectious Diseases and Microbiology. University of Sydney. [Medline]. an area endemic for bancroftian filariasis. Griffith University.. American Society for Microbiology. Tropical lymphedemas--control and prevention. Pediatric Infectious Diseases Society. Westmead Hospital. Phi Beta Kappa. PharmD. MD is a member of the following medical societies: American College of Physicians. Division of Allergy. [Medline]. Pharma.Filariasis Treatment & Management: Approach Considerations. MD is a member of the following medical societies: American Academy of Pediatrics. Haiti. Steinmann P. American Association of Immunologists. Sir Albert Sakzewski Viral Research Centre. [Full Text]. MD is a member of the following medical societies: Ambulatory Pediatric Association. Infectious Diseases Society of America. Magesa SM. 5. Nigeria. [Full Text]. Budge PJ. [Full Text]. Keiser J. Immunology and Infectious Diseases. Dalgaard M. 2010 Apr 20. Mathieu E. Milord MD. Dorkenoo A. Ochsner Children's Health Center. and Wilderness Medical Society Disclosure: Nothing to disclose. American Medical Association.medscape. University of Nebraska Medical Center College of Pharmacy. 4(4):e668. A laboratory-based surveillance system for Wuchereria bancrofti in Togo: a practical model for resource-poor settings. Am J Trop Med Hyg. Medscape Drug Reference Disclosure: Medscape Salary Employment Robert W Tolan Jr. MD Program Director.

Mewara A. Parasite Immunol. 1999. Ottesen EA. Am J Trop Med Hyg. Pharma. J Infect Dis. 2015. Madhiyazhagan P. [Full Text]. 15(11):437-42. Rosenblatt JE. Diggle PJ. Xu C. 89(1):72-4. 2015 Dec 9. Dhanda V. Bhattacharya SM. Tropical Infectious Diseases: Principles. 2011 Jul 15. 27. Chundu K.com/article/217776-treatment#d10 8. Trans R Soc Trop Med Hyg. Maizels RM. World Health Organ Tech Rep Ser. Clin Microbiol Rev. Association between onchocerciasis and epilepsy in the Itwara hyperendemic focus. Liu X. Garg PK. Am J Trop Med Hyg. [Medline]. 2011 Aug. 10. [Medline]. Ojony JO. Kar SK. [Medline]. 19. Lammie PJ. Parasitol Res. [Guideline] World Health Organization. [Medline]. Feiz-Erfan I. Kazura J. disease pathogenesis. Hamid F. Trop Med Int Health. Weil GJ. 2002 Dec. Eberhard ML. Int J Clin Exp Med. Transmission intensity and human immune responses to lymphatic filariasis. Punkosdy GA. Li J. 2011 Jun. and treatment. 6(5):e1655. Hoerauf A. Human lymphatic filariasis: genetic polymorphism of endothelin-1 and tumor necrosis factor receptor II correlates with development of chronic disease. Mahajan RC. Hu SL. PLoS Negl Trop Dis. West Uganda: controlling for time and intensity of exposure. J Infect Dis. Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology. [Medline]. 88(3):601-5. Das PK. Jain BK. 22. [Full Text]. 84(5):733-7. 104 Suppl:S71-9.. [Full Text]. Pearlman E. 87(6):1073-5. Wanji S. Am J Trop Med Hyg. Am J Trop Med Hyg. Michael E. 25. 87(6):963-4. 23(7):363-71. 16. 29. Genetic characterization of atypical Mansonella (Mansonella) ozzardi microfilariae in human blood samples from northeastern Peru. Mathison BA. Sahoo PK. Noma M. [Medline]. Mascarello M. Tekle AH. Pani SP. 2004 Jan 1. 1992. Palaniswamy SS. [Medline]. Boussinesq M. Panda AK. Cuenco KT. Ottesen EA. Kaiser C. [Medline]. 20. Parasitol Today. [Medline]. [Medline]. Clin Infect Dis. 821:1-71. 2000--2009. Hoerauf A. Bhatt S. Swain BK. et al. Eberhard ML. 16/10/2016 20:43 . Parasitology. Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics. Baird JB. Most of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage. Circulating filarial antigen detection in brugian filariasis. Guiliano DB. Tripathi PK. Hoffman RS. et al.Filariasis Treatment & Management: Approach Considerations. 2002 Feb. [Medline]. 2011 Jul 29. Puruehnce MF. 30. 15. Lammie PJ. 2011 Jun. 2001 Jul. Zoonotic Onchocerca lupi infection in a 22-month-old child in Arizona: first report in the United States and a review of the literature. [Medline]. Gobbo M. Wiria AE. Le Goff L. 5(6):e1210. Mathison BA. Malla N. Parasitology. Walker DH. Ocular zoonotic onchocerca infection in a resident of Oregon. 13. 28. Kashyap B. et al. Boulesteix J. Arrospide N. Nataraj D. 66(2):163-9. Vanamail P. Satapathy AK. fungal. Sims AC. The economic burden of lymphatic filariasis in India. [Medline]. et al. 8 (9):16496-16503. Parasitol Today. 24. Taylor MJ. 1-8. Am J Trop Med Hyg. [Medline]. Xiao T. Philadelphia. et al. 35. PLoS Negl Trop Dis. Progress toward elimination of lymphatic filariasis--Togo. [Full Text]. 11. [Medline]. Wolbachia bacteria of filarial nematodes. 2012 Sep. Rossanese A. Am J Trop Med Hyg. Trop Med Int Health. PA: Churchill Livingstone. Ramaiah KD. Amazigo UV. Guyatt H. et al. 1995 Jan-Feb. 2000 Jun. Wibowo H. 60(29):989-91. Kabagambe G. 12. eds. 49(7):1103-8. Genital filariasis masquerading as testicular torsio. [Medline]. Recuenco S.medscape. Angheben A. Kipp W. [Full Text]. discussion 188-96. [Medline]. Michael E. Yuvaraj J. Ann N Y Acad Sci. Sartono E. [Full Text]. Carme B. Marcos LA. Gobbi F. Roberts JM. Rath K. The Wellcome Trust Lecture. Reactivity to bacterial. Carbon and silver nanoparticles in the fight against the filariasis vector Culex quinquefasciatus: genotoxicity and impact on behavioral traits of non-target aquatic organisms. 18. 21. J Vector Borne Dis. 44(6):684-90. 85(2):225-8. Ravindran B. 2009 Oct 1. Rubaale T. 979:131-42. Gentil K. Murugan K. 48(2):119-21. [Medline]. 36. 2015 Nov 28. [Medline]. [Medline]. 9 of 11 http://emedicine. [Medline]. Lymphatic filariasis: an infection of childhood. 2006 May. 14. 2001 Aug. 2011 Jul. The pathogenesis of filarial lymphedema: is it the worm or is it the host?. Zouré HG. Lymphoscintigraphy in unilateral lower limb and scrotal lymphedema caused by filariasis. Kerketta AS. and parasite antigens in patients with lymphedema and elephantiasis. 16(6):251-3. 34. Am J Trop Med Hyg. 2012 Dec. 32. Lymphatic filariasis: the disease and its control. [Medline]. [Medline]. et al. Vol 2: 852. 33. Tamarozzi F. 17. [Medline]. Wammes LJ. Guerrant R. 1991 Jun. 204(2):315-22. Establishment of lymphatic filarial specific IgG4 indirect ELISA detection method. Babu BV. [Medline]. Ostovar GA. 2012. Boutes H. Five cases of encephalitis during treatment of loiasis with diethylcarbamazine. 26. 1992. Tukesiga E. 11(5):712-7. Subramanyam P. Infection and disease in lymphatic filariasis: an immunological perspective. Weller PF. Fifth report of the WHO Expert Committee on Filariasis. Blaxter ML. Witt C. Am J Trop Med Hyg. Fenn K.. Episodic adenolymphangitis and lymphoedema in patients with bancroftian filariasis. The geographic distribution of Loa loa in Africa: results of large-scale implementation of the Rapid Assessment Procedure for Loiasis (RAPLOA). MMWR Morb Mortal Wkly Rep. [Medline]. Lamb TJ. George A. Laboratory diagnosis of infections due to blood and tissue parasites. 24(3):459-68. 1999 Nov. Bishop HS. Fischer PU. 6(8):582-606. 2011 May. Impact of chronic lymphatic filariasis on quantity and quality of productive work among weavers in an endemic village from India. Charles JL. Taylor MJ. 189(1):120-7. 2013 Mar. [Full Text]. 2012 Dec. 87(3):491-4. Hobohm D. Halliday A. Kurniawan A. 31. King CL. 23. Grenfell BT. Addiss DG. et al. [Medline]. Cabezas C. [Full Text]. Streit TG. [Full Text]. Wei QK. [Medline]. et al. Case report: Loiasis with peripheral nerve involvement and spleen lesions. Shenoy RK. 9. Centers for Disease Control and Prevention. Pathogens and Practice.

Zoerhoff KL. Batsa L. 62. 38. [Full Text]. 85(2):229-37. 10(9):818-25. 44. Pfarr K. 1999 Dec. Pfarr K. 83(37):333-41. 59. Kabore A. Beach MJ. 23(2):124-31. 60. 2010 Dec 1. Schuetz A. Weinkopff T. A single dose of doxycycline in combination with diethylcarbamazine for treatment of bancroftian filariasis. [Medline]. Kwarteng A. [Medline].medscape. et al. 42. Weaver A. Ottesen EA. Adjobimey T. Siba PM. Am J Trop Med Hyg. PLoS Negl Trop Dis. Kiniboro B. Grady C. Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial. Boyd A. Onchodermatitis. van den Berg H. Am J Trop Med Hyg. 1994 Jul.. [Full Text]. Amaral F. PLoS Negl Trop Dis. The impact of mass drug administration and long-lasting insecticidal net distribution on Wuchereria bancrofti infection in humans and mosquitoes: an observational study in northern Uganda. 2011 Jul 15. Jana PK. Milord MD. [Medline]. Gass K. Glaziou P. Evaluation of the whole blood filariasis ICT test for short-term monitoring after antifilarial treatment. Baker M. 51(11):1229-35. 47. et al. Murdoch ME. Bhattacharya S. Trans R Soc Trop Med Hyg. 2012. [Medline]. 2005 Oct 19. [Medline]. 49. Kucerova Z. 58. 52. [Medline]. [Medline]. et al. Mand S. [Full Text]. Klarmann U. Infect Dis Clin North Am. [Full Text]. Moulia-Pelat JP. Mand S. Parasit Vectors. 6(1):e1479. Addiss DG. 48(2):101-4. Mehlotra RK. Lancet Infect Dis. [Medline]. 55(5):621-30. The role of albendazole in programmes to eliminate lymphatic filariasis. 2011 Jan. 2010 Jul. [Medline]. et al. [Full Text]. 1993 Sep. Batsa L. Eberhard ML. 45. [Medline]. Major progress toward eliminating lymphatic filariasis. [Full Text]. Opio T. Multiplex bead assay for serum samples from children in Haiti enrolled in a drug study for the treatment of lymphatic filariasis. 82(6):1030-3. Kloos Z. 2010 Jun. Medeiros Z. 2012 Sep. Vaccine research and development for the prevention of filarial nematode infections. [Medline]. Gelband H. 40. Garner P. Pharm Biotechnol. Fischer PU. Henry-Halldin CN. [Full Text]. 53. 43. Beau de Rochars MV. [Medline]. [Medline]. Mand S. Alexander ND. Kyabayinze DJ. 5(7):e1241. Specht S. Am J Trop Med Hyg. Integrated implementation of programs targeting neglected tropical diseases through preventive chemotherapy: proving the feasibility at national scale. Gyapong J. Coulibaly SY. Noroes J. Grieve RB. 2008 Sep 12.. [Medline]. Sujariyakul A. Use of high-dose. 54. 347(23):1885-6. Kelly-Hope LA. Esterre P.com/article/217776-treatment#d10 37. [Full Text]. Reduction in acute filariasis morbidity during a mass drug administration trial to eliminate lymphatic filariasis in Papua New Guinea. et al. Clin Infect Dis. 1995. Am J Trop Med Hyg. [Medline]. 51. Tisch DJ. Tisch DJ. Marfo-Debrekyei Y. Albendazole for the control and elimination of lymphatic filariasis: systematic review. 89(4):441-3. CD003753. Gamble C. Specht S. Linehan M. et al. Mitra K. A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis. 2013 Jan. Pharma. Hanson C. [Medline]. 2005 Sep. Global programme to eliminate lymphatic filariasis. 2010 Apr. et al. [Full Text]. Washington CH. 41(4):800-12. 64. Coulibaly YI. Critchley J. Critchley J. 81(4):702-11. 2002 Dec 5.Filariasis Treatment & Management: Approach Considerations. 63. Wisnewski N. Dreyer G. Tripp CA. Assessment of immunochromatographic test for rapid lymphatic filariasis diagnosis. Southeast Asian J Trop Med Public Health. Coutinho A. Moss DM. 2011 Jul. Malaria and lymphatic filariasis: the case for integrated vector management. Gamble C. et al. Ottesen EA. Klarmann U. Luquiaud P. Dembele B. Plichart C. 1988 Nov. [Medline]. PLoS Pathog. Og4C3 circulating antigen: a marker of infection and adult worm burden in Wuchereria bancrofti filariasis. [Medline]. Blood-Zikursh MJ. Secondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings. 39. Marfo-Debrekyei Y. Klarmann U. 41. PLoS Negl Trop Dis. Specht S. Sanprasert V. [Full Text]. Addiss D. Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis. Chatterjee A. Nen A. et al. PLoS Negl Trop Dis. et al. 170(1):247-50. J Vector Borne Dis. A study on coverage. 2000 Apr. 2006 Sep. Wkly Epidemiol Rec. Boakye D. Ejere H. [Medline]. Streit T. 2009 Oct. 55. Clin Infect Dis. Bradley M. Garner P. Gray LR. Lal RB. Deininger S. et al. Debrah AY. Addiss D. 57. 158(5):1034-7. compliance and awareness about mass drug administration for elimination of lymphatic filariasis in a district of West Bengal. and Wuchereria bancrofti infections. 7(3):619-33. WHO. 61. Nguyen NL. J Infect Dis. Lammie PJ. Ashton RA. twice-yearly albendazole and ivermectin to suppress Wuchereria bancrofti microfilarial levels. [Medline]. Molecular-based assay for simultaneous detection of four Plasmodium spp. Konate S. 10 of 11 http://emedicine. 2011 Jun. et al. Ismail MM. 2(9):e92. Dolo H. 62(4):502-3. [Medline]. Karmakar PR. [Medline]. Enhanced diagnostic specificity in human filariasis by IgG4 antibody assessment. 6(4):e1611. 6:737-68. Ottesen EA. Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti. India. Dagoro H. [Medline]. Direct assessment of the adulticidal efficacy of a single dose of ivermectin in bancroftian filariasis. 6(4):355-8. 84(1):5-14. 56. Trop Med Int Health. Lindsay SW. Sahoo PK. 2012. [Medline]. [Medline]. Satapathy AK. Am J Trop Med Hyg. [Medline]. J Infect Dis. Mand S. Ejere H. Curr Opin Infect Dis. [Medline]. Filarial infections. et al. Nguyen NL. 2012 Jan. Arndts K. N Engl J Med. Nuchprayoon S. Edwards T. et al. Ottesen EA. Lovegrove M. Frank GR. 15(9):382-6. Matwale G. 50. Gelband H. Debrah AY. Cochrane Database Syst Rev. Chanteau S. Lahiri SK. 1995 Jul-Aug. [Medline]. Sanogo D. Plichart C. 46. 6(10):e1807. 1999 Sep. Parasite. Horton J. Albendazole for lymphatic filariasis. Parasitol Today. 4:134. 48. Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine. Bockarie MJ. Drexler N. 16/10/2016 20:43 . 13(1):89-94. 2011 Aug. Priest JW. Auma A.

medscape. 69. Dunyo SK. [Medline].com/article/217776-treatment#d10 65. Medscape Reference © 2011 WebMD. Kumaraswami V. Schiefer A. Vijayasekaran V. more frequent treatment of Wuchereria bancrofti. Doumbia SS. Coulibaly SY. Nkrumah FK. 2009 Oct 8. [Medline]. Dembele B. 2010 Dec 1. Higher-dose. Sadanandam A. et al. [Medline]. Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo. J Infect Dis. Single-dose treatment of Wuchereria bancrofti infections with ivermectin and albendazole alone or in combination: evaluation of the potential for control at 12 months after treatment. Diallo AA. Lipner EM. N Engl J Med.. [Medline]. Schmitz A. Perumal Pillai SV. Pharma. Trans R Soc Trop Med Hyg.. A randomized trial of doxycycline for Mansonella perstans infection. 67. A controlled trial of ivermectin and diethylcarbamazine in lymphatic filariasis. 206(2):249-57. Clin Infect Dis. Schäberle TF. 66. et al. 94(4):437-43. Lämmer C. LLC 16/10/2016 20:43 . [Full Text]. 11 of 11 http://emedicine. Coulibaly YI. 1990 Apr 19. Johnston KL. 51(11):1236-7. 322(16):1113-7. 361(15):1448-58. Kazura JW.Filariasis Treatment & Management: Approach Considerations. N Engl J Med. et al. Simonsen PE. [Medline]. 2012 Jul 15. Frederick S. Ottesen EA. 68. 2000 Jul-Aug. Specht S.