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LIQUID IN

HARD CAPSULES

A NOVEL DOSAGE FORM

Capsules, over time have globally become the choice of pharmacists aspiring towards superior patient
compliance levels, improved release profiles and unique identities. However, given the advantage of liquids
especially in the above mentioned facets, the utility of capsules has slowly but surely diminished.
The advent of Softgel encapsulation has led to the simplification of liquid drug delivery and has had an
impact on sub-optimal manufacturing yield and even quality. Higher costs have driven down demand for
this dosage form.
ACG, a pioneer in capsule technology, working constantly in tandem with the changing trends of the
pharmaceutical industry, has developed the unique Fluidocap technology that allows liquids of a wide
variety to be filled into hard capsules.
Given the promise of assured quality, timely
improvements in yield and significantly lower
costs, liquid filling in hard capsules has proven
to be a highly effective substitute to liquid
dosages as well as Softgels.
The flexibility to fill hard capsules with liquids
in combination with tablets, pellets, and have
capsules within capsules allows R&D centres
across the industry to innovate with ease and
consistently positive results.
The Fluidocap series is offered in various
capacities ranging from a lab model of 1,000
capsules per hour to a high-speed model
offering 60,000 capsules per hour. The
Fluidocap technology is the combination of
various mechanisms and systems that have
been developed at ACG to maximize the yield
and optimize the efficiency of filling liquids
into hard capsules. These systems include:
No Capsule No Fill (NCNF)
Seal free dosing block
Formulation temperature control
Purging of filled capsules
Combination filling provisions
Industrial PC interface

Seal Free Dosing Block (Optional)


Capable of processing low viscocity liquids
Easy to clean hence maximizing uptime
Eliminating cross contamination
Higher accuracy in fill weights
No-drip mechanism at stoppage
Higher and more assured productivity

Pioneering Technologies Since Four Decades. ACG-Pam

Technologically Driven
ACG-Pam has been pioneering newer and better technologies for over four decades, and helping the
pharmaceutical industry address its challenges. With a dedicated workforce for spearheading the design
and development of class-leading technologies, ACG-Pam is constantly engaged in building a range of
new products. From the Accura range of 100% checkweighers to the highly sophisticated ZRO range of
capsule filling machines to the robust and ecient range of tablet presses, ACG-Pam is driven by a
passion for innovation and developing market-leading technologies. At the heart of these technologies
is our collaboration with leading component manufacturers across the world along with our capability
and state-of-the-art infrastructure to fabricate precision parts in-house.

CODE
Customized Oral Dosage Encapsulation (CODE) helps pharmaceutical companies achieve unique dosage
forms for various combinations of formulations. ACG-Pam oers these retrofittable and completely
customized attachments for dosing a combination of pellets, powder, mini and micro tablets, capsules,
and softgel - all in one capsule. This degree of customization is what dierentiates ACG-Pam from the
rest. Its not just technology, but solutions that are built to suit specific requirements.

Customer Support
Understanding customer needs and responding with prompt information form the core of ACG-Pam's
services. ACG-Pam has a dedicated team of sales and service personnel catering exclusively to customers
all over the world. With oces across India, Brazil, Bangladesh, China, Indonesia, Thailand, the UK and the
US, ACG-Pam ensures it is within the reach of its customers always. Customers also have the convenience
of logging-in their requests for service, spares and equipment directly through ACG-Pams website
www.acg-pam.com

Synergistic Solutions
ACG Associated Capsules and ACG Lukaps - both members of ACG Worldwide - are together the worlds
second largest manufacturers of empty hard capsules. Catering to the global pharmaceutical and dietary
supplement industries in over 100 countries, the companies produce over 80 billion capsules annually
through its three plants in and around Mumbai, India, another plant in Ludbreg, Croatia, and a new
state-of-the-art facility in Indore, India.

FlofitTM
Liquid in Capsule. Solid in Performance.
ACG Associated Capsules, the worlds
second-largest
empty
hard
capsule
manufacturer and a member of ACG Worldwide,
offers Flofit - a two-piece empty hard capsule
that is ideal for filling and band-sealing liquids,
pastes and wax. FlofitTM makes a significant
contribution to the development of efficacious
pharmaceutical products, by providing the
flexibility to rapidly develop and test
formulations in-house. The process can be
scaled-up, yet kept in-house, much similar to
the operations seen in tableting or
powder/pellet filling in hard capsules. In
addition, FlofitTM offers better bioavailability and
enhanced appearance, thereby, improving
patient compliance.
Over the years, various research and development
efforts have documented that liquid in hard
capsules can offer solutions for some
challenging compounds. A large number of
pharmaceutical companies have directed their
research efforts towards investigating and
understanding benefits of encapsulating liquid
in two-piece hard capsules.
Today, pharmaceutical companies across the
world want to extend a number of their
products in liquid-in-hard-capsule. By far, this
remains a relatively unexplored alternative that
could lead to quicker relief for patients, an
extension of the drugs patent life, and most
importantly, manufacturing cost effectiveness.

Enables liquid filling of hard capsules


followed by band sealing
Improves bioavailability and product stability
Enhances patient compliance by eectively
masking taste and odor
Lends a distinct appearance and helps
dierentiate in a me-too marketplace
Available in gelatin as well as HPMC
Available with up to four-color circular-printing

Fluidocap 1000
R&D Scale Filling and Sealing
The Fluidocap 1000 is a semi-automatic machine that
integrates the filling, closing and band sealing processes
in one compact and robust machine. It comes with the
versatility to process a large variety of capsules from sizes
00 to 4 of both HGC and HPMC (Veg) variety of FlofitTM
capsules designed by ACG for the specific application.

Salient Features
Output: Up to 1,000 capsules per hour
Compact filling and sealing equipment
Mechanisms to handle 40 cps to 3,000 cps formulations
including pastes, hot melt and thixotropics
Band sealing in order to aid integrity of dosage form,
provide brand distinction and enhance shelf life
Flexibility to fill and seal gelatin as well as HPMC
capsules

Fluidocap 1000: Technical Specifications


Output

Up to 1,000 capsules/hour

Liquid Viscosity Range

40 cps to 3,000 cps and semi solids, which can be heated


and converted into liquid state for the filling operation

Temperature of Fill

Between room temperature to 75 C

Temperature Controller

Available to control the set temperature within 2 C

Electric Supply

220 V, 50 Hz, Single Phase

Compressed Air

60 lpm @ 6 bar

Connected Load

1.4 kW (Main machine with water pump(s) + water heater)

Dimensions (L x W x H)

1505 mm x 830 mm x 1975 mm

Gross Weight

425 Kg

Shipping Dimensions
(L x W x H)

1700 mm x 1350mm x 2450 mm

Shipping Weight

570 Kg

Layout
1505

1975

1060

830

Fluidocap Filling
Fluidocap filling machines are easy-to-operate fully
automatic machines for liquid filling of two-piece hard
capsules with formulations ranging in viscosity from 10 cps
to 80,000 cps in medium to large batches. The salient
features allow the machine to fill liquids of varied
characteristics such as free flow liquid, pastes,
suspensions, thixotropic, and hot melts.

Salient Features
Hot water circulation to maintain formulation
temperature up to 75 C
Stirrers in hopper to facilitate flow
Inert-gas purging for oxygen sensitive products
IPC features option to feed recipe programs to
ensure easy changeover and flexibility with 21 CFR
Part 11 compliance
Interlocks for safety cover, pressure maintenance
and No Capsule No Fill (NCNF) alerts
ACG FlofitTM capsules for ideal liquid filled capsules
Pellet, tablet, capsule in capsule filling systems
Productivity optimization through ancillary line
systems

Fluidocap Filling: Technical Specifications


Output

F20 standard dosing: up to 20,000


Seal free dosing up to 35,000 capsule per hour
F40 standard dosing: up to 40,000
Seal free dosing up to 60,000 capsule per hour

Liquid Viscosity Range

10 cps to 80,000 cps

Temperature of Fill

Between room temperature to 75 C

Temperature Controller

Available to control the set temperature within 2 C

Electric Supply

220 V, 50 Hz

Vacuum Required

1100 LPM @ 26 of Hg

Compressed Air

60 LPM @ 6 bar

Connected Load

8 kW
2.25 kW (Main machine)
4.95 kW (Main machine + Hot water circulation motors +
Vacuum pump)
7.15 kW (Main machine + Hot water circulation motors +
Vacuum pump + Air compressor)

Dimensions (L x W x H)

1300 mm x 1100 mm x 2000 mm

Gross Weight

2350 Kg

Shipping Dimensions
(L x W x H)

2134 mm x 1660 mm x 2134 mm

Shipping Weight

2550 Kg

Fluidocap Sealing
Augmenting the unique identity and providing tamper
evident technology to the liquid filled capsules ACG-pam
oers Fluidocap S40 and S70, band sealing systems. To
ensure high quality and optimized efficiency this
advanced band sealing technology includes key features
and mechanisms.

Salient Features
Dual heating pad system for gelatin temperature
maintained within 2 C
Peristaltic pumps to assist controlled flow of
banding gelatin
Adjustable sealing rollers with delivery optimized
design
Centrifugal blowers for dehumidified air in drying
chamber
Carrier links designed for careful handling of
capsules

Fluidocap Sealing: Technical Specifications


Output

S40: up to 40,000 capsules per hour


S70: up to 70,000 capsules per hour

Capsule Size

00 to 4

Electrical Requirements

415 V, 3 Phase+E, 50 Hz or as per user specification

Connected Load

5 kW

Compressed Air

60 LPM @ 6 bar

Peristaltic Pump

S40: 90W, 220V/50 Hz - 1200 rpm


S70: 90W, 220V, 50 Hz - 1250 rpm, O/P: 80 rpm

Machine Dimensions
(Lx W x H)

S40: 3532 mm x 340 mm x 2541 mm


S70: 2900 mm x 1050 mm x 2420 mm

Net Weight

S40: 1300 kg
S70: 1500 kg

Shipping Dimensions (L x W x H)
Main Machine

S40: 2286 mm x 1016 mm x 2336 mm


S70: 2135 mm x 1830 mm x 2290 mm

Dryer Unit

S40: 2210 mm x 762 mm x 2336 mm

Blower Unit and Trolley

S40: 1676 x 1066 x 914 (mm)


S70: 1830mmX1070mmX1070mm

Control Panel

S40: 1525mmX1300mmX1930mm
S70: 1525mmX1300mmX1930mm

Gross Weight

S40: 1800 kg
S70: 2000 kg

F20+S40
Layout
500

TRANSFORMER

350

800

VACUUM
PUMP

610

340

600

ELECTRICAL
PANEL

2700

800

500

HOT WATER
CIRCULATION
SYSTEM

1100

COMPRESS AIR

3533

FLUIDOCAP S40

450

800

800

800

CONTROL PANEL

800

FLUIDOCAP F20

1300

800

2900

500

VACUUM PUMP

805

610

TRANSFORMER

3532

3500

60

FLUIDOCAP S40

CONTROL PANEL

780

940

1850

1850

1810

600

2000

2541

2540

FLUIDOCAP F20

145

HOT WATER
CIRCULATION
SYSTEM

OPERATING PANEL

ELECTRICAL PANEL

F40+S70
Layout
500

1050

TRANSFORMER

350

800

VACUUM
PUMP

610

600

2700

1100

ELECTRICAL
PANEL

800

500

HOT WATER
CIRCULATION
SYSTEM

2900

COMPRESS AIR

FLUIDOCAP S70

450

800

800

HMI

FLUIDOCAP F40

1300

800

2900

CONTROL
PANEL

800

800

500

610

TRANSFORMER

60

VACUUM PUMP

CONTROL PANEL

FLUIDOCAP S70

SIDE VIEW

780

940

920

HOT WATER
CIRCULATION
SYSTEM

1850

1810

600

2000

2420

1960

1850

FLUIDOCAP F40

145

OPERATING PANEL

ELECTRICAL PANEL

ACG Pam Pharma Technologies Pvt. Ltd.


127, Kandivali Industrial Estate, Kandivali (West), Mumbai - 400 067, India
Tel: +91.22.3078.0701/02; Fax: +91.22.2868.3091
E-mail: sales.pam@acg-world.com
BANGLADESH
AGG Bangladesh Pvt. Ltd.
House No. 369, Road No. 28,
Flat No. 4A, New DOHS Mohakhali,
Dhaka-1206, Bangladesh
BRAZIL
ACG do Brasil S/A
1714, Rua Cristovo Pereira Campo Belo, So Paulo, 04620-013 Brazil
Tel: +55.11.5096.1704
Email: sales.brasil@acg-world.com
CHINA
ACG (Shanghai) Co. Ltd.
1607, Guoli Mansion, 1465 Beijing Rd, Shanghai 200040
Tel: +86.21.5212.0007; Fax: +86.21.5212.0042
Email: sales.china@acg-world.com
EUROPE
ACG Europe Ltd.
159 Princes Gardens, London, W3 0LS, UK
Tel: +44.208.932.0308
Email: sales.acpl@acg-world.com
INDONESIA
P.T. ACG Indonesia Ltd.
JI. GadingKirana Barat IX, Blok C10 No. 26,
KelapaGading, Jakarta Utara -14240, Indonesia
Tel: +62.21.45874093; Fax: +62.21.45874011
Email: acg.indonesia@acg-world.com
NORTH AMERICA
ACG North America LLC
229, Durham Ave., South Plainfield, NJ 0780, USA
Tel: +1.908.7573425; Fax: +1.908.757.3287; Toll Free: +1.877.618.3344
Email: sales.acgna@acg-world.com
THAILAND
ACG Capsules (Thailand) Co. Ltd.
Ocean Tower 2,
17th Floor, Soi Sukhumvit 19 (Wattana)
Sukhumvit Rd, Kwaeng Klongtoey Nua,
Khet Wattana, Bangkok 10110
Phone: +66.266.1771/+66.266.1772
Fax: +66.266.1773
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