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GUIDE BOOK ON MERCURY

FREQUENTLY ASKED QUESTIONS (FAQs)

Ir Hj Jamaludin b Hj Takei
Mercury Taskforce Team Leader/Head Operations
Area Operations Duyong, Peninsular Malaysia Operations, Kerteh, Terengganu
1 Aug 2005, Rev 0
Any information, data, conclusion and/or advice offered or given by or on behalf of PETRONAS is to be
construed as a statement of opinion and not as representation of any kind as to the effect of the said
information, data, conclusion and/or advice

Guide Book on Mercury Frequently Asked Questions

GUIDE BOOK ON MERCURY

TABLE OF CONTENTS

PAGE

Foreword.

1. Introduction

2. Mercury Chemistry

3. Mercury Handling Safety At Home

10

4. Effects of Mercury to Children and Family.

13

5. Routes of Exposure

15

6. Signs and Symptoms of Exposure.

15

7. Mercury Risks Exposure Limits.

18

8. Impact of Mercury to Health..

20

9. Impact of Mercury to Environment

24

10. Impact of Mercury to Product Quality, Process Equipment and Materials...

32

11. Medical Surveillance

34

12. Treatment to Mercury Exposure...

44

13. Analytical Methods..

46

14. References

47

15. Glossary

56

16. Acronyms, Abbreviations

57

Guide Book on Mercury Frequently Asked Questions

FOREWORD

In our operations be it gas, oil and condensate, the presence of mercury in the
hydrocarbon compounds and fluids has been a concern due to the degenerative effects of
mercury to human health, occupational safety, environmental fate and processing facility.

The subject has been widely discussed amongst the upstream and downstream oil and gas
community and its a manifestation that mercury is really an element that is not to be
underestimated. We tend to fear most when we understand the subject least.

The purpose of this guidebook is to provide an accurate facts and information on


mercury, its physical properties, chemistry, toxicokinetics and its impacts to our daily
work life. It also relates to questions that have been frequently asked time and again with
reference to this toxic element.

In addition it will also briefly describe the appropriate control measures to be in place
when dealing with this toxic element. The information and questions have been designed
in a simple manner so that the audience can get a better understanding thus getting the
message across.

With the establishment of this small effort to educate and to provide awareness to the oil
and gas and petrochemical community, we hope this noble intention would propel us to
safeguard our staff, property and to protect the environment.

Guide Book on Mercury Frequently Asked Questions

1. INTRODUCTION
The Global Mercury Cycle
Mercury is a natural occurrence element present throughout the environment in both
environmental media and biota. It is estimated that the largest repository of mercury is
ocean sediments that may contain about 1017 g of mercury, mainly as HgS, ocean waters
1013 g, soils and freshwater sediments 1013 g, the biosphere 1011 g (mostly in land biota),
the atmosphere 1018 g and freshwater 107 g of mercury (Nriagu, 1979). However, a more
recent estimate of the global atmospheric repository is 25 Mmol or approximately 5x109
g of mercury (Fitzgerald, 1994). The estimate is 50 times the previous estimate (Nriagu,
1979). Hence, it illustrates how rapid the scientific understanding of environmental
mercury that has changed over the years.
The estimation of mercury concentrations in the environment as part of the global
mercury cycle has been debated among several authors especially in the selection of
techniques. A number of different techniques have been used to estimate the preindustrial mercury concentrations in the environment. It is rather difficult to separate
current mercury concentrations by origin i.e. anthropogenic or natural due to the
continuous cycling of the element in the environment. The (Expert Panel on Mercury
Atmospheric Processes, 1994) concluded that pre-industrial atmospheric concentrations
are approximately one-third of the current atmospheric concentrations. The panel
estimated that anthropogenic emissions are in the range of 50 75% of total annual input
to the global atmosphere. The estimates are corroborated by (Lindqvist et al; 1991) who
estimated that 60% of the current atmospheric concentrations are the result of
anthropogenic emissions. On the other hand (Porcella, 1994) estimated that this fraction
was at 50%, and (Horvat et al; 1991) who assessed the anthropogenic fraction at 40
50% of the current total. Therefore, when the estimates are combined, they indicate that
between 40 75% of the current atmospheric mercury concentrations are as a result of
anthropogenic releases. This understanding is limited by substantial uncertainties
regarding the level of natural emissions as well as the amount and source of mercury that
is re-emitted to the atmosphere from soils, watersheds and ocean waters. Recent estimates

Guide Book on Mercury Frequently Asked Questions

indicate that of the approximately 200,000 tons of mercury emitted to the atmosphere
since 1890, about 95% resides in terrestrial soils, 3% in the ocean surface waters and 2%
in the atmosphere (Expert Panel, 1994).
Comparisons of measurements and historical records within the last 15 20 years,
indicate that the total global atmospheric mercury burden has increased since the
beginning of the industrialized period by a factor of between 2 to 5 as illustrated in Fig 1:

Top: current mercury budget and fluxes; Bottom: pre-industrial mercury budget and
fluxes, Source: Adapted from Mason et al., 1994

Guide Book on Mercury Frequently Asked Questions

2. MERCURY CHEMISTRY
What is mercury?

Mercury is a toxic metal and a natural element, commonly seen as a shiny, silverwhite, odorless liquid metal.

Mercury is a persistent, bioaccumulative, and toxic (PBT) pollutant.

Where is mercury found?

Mercury (Hg) is a naturally occurring element.

At present it is difficult to understand the geologic origin of mercury in


hydrocarbons due to lack of data on total mercury and species concentration in
many of major oil and gas fields in the world.

Crude oil and natural gas originate from geological formations associated with
ancient basins (locations of accumulation of ancient organic material).

It is generally believed that the accumulation of petroleum in reservoirs occurred


by transformation (maturation) of the source organic material to molecular
hydrocarbons with the process being assisted by heat and pressure from burial of
the original deposits.

Subsequent hydrocarbon fluid migration to locations of accumulation (traps)


accounts for the discovery of petroleum in porous reservoirs. Hence, it is where
mercury can be concluded as a natural occurrence element because it originates
from the rock formation and being evacuated to surface together with other
hydrocarbon components

What is the chemistry of mercury?

There are three forms of mercury in the environment: elemental, organic and
inorganic

Each has its own level of toxicities.

Guide Book on Mercury Frequently Asked Questions

What are the physical properties of mercury (elemental)?

The physical properties of mercury are as shown in Table 1.

Table 1: Common physical properties of elemental mercury


Atomic number

80

Atomic weight

200.59 atomic mass units

Boiling point

357 C (657 F)

Boiling point/rise in pressure

0.0746 0C/torr

Density

13. 546g/cm3 at 20C (0.489 Ib/in3 at 68 F

Diffusity (in air)

0.112 cm2/sec

Heat capacity

0.0332 cal/g at 20C (0.060 Btu/Ib at 68 F

Henrys law constant

0. 0114 atm m2/mol

Interfacial tension (Hg/H2O)

375 dyne/cm at 20C (68 F)

Melting point

-38.87C (-37.97 F)

Saturation vapour pressure

0.16 N/m3 (pascal) at 20C (68 F)

Surface tension (in air)

436 dyne/cm at 20C (68 F)

Vaporization rate (still air)

0.007 mg/ cm2hr for 10.5 cm2 droplet at 20C

Guide Book on Mercury Frequently Asked Questions

What is the typical mercury species found in natural gas condensates?

Examples of mercury species that may be present in condensate and correspond to


the boiling points are as Table 2.

Table 2: Typical list of mercury species and their boiling points


Compounds

Formula

Boiling point (C)

elemental

Hg0

357

Di-methyl mercury

Hg(CH3)2

96

Di-ethyl mercury

Hg(C2H5)2

159

Di-isoprophyl mercury

Hg(iC3H7)2

170

Di-prophyl mercury

Hg(C3H7)2

190

Di-butyl mercury

Hg(C4H9)2

206

In which form does mercury is most common?

Mercury occurs most prevalently in the elemental form or in the inorganic


mercuric form.

What is elemental mercury?

Also known as metallic mercury

Occurs naturally in three valences states:


o elemental (Hg0),
o monovalent-mercurous (Hg1+),
o diavalent mercuric (Hg2+).

Metallic mercury is a shiny, silver-white metal that is a liquid at room


temperature.

Metallic mercury is the elemental or pure form of mercury (i.e., it is not combined
with other elements).

Guide Book on Mercury Frequently Asked Questions

At room temperature, some of the metallic mercury will evaporate and form
mercury vapors.

Mercury vapors are colorless and odorless.

The higher the temperature, the more vapors will be released from liquid metallic
mercury.

Elemental mercury is the most stable and is only slightly water soluble.

Some people who have breathed mercury vapors report a metallic taste in their
mouths.

What is organic mercury?

When mercury combines with carbon, the compounds formed are called "organic"
mercury compounds or organomercurials.

Organic mercury compounds are the most toxic of all especially species like
methyl or di-methyl mercury.

What is inorganic mercury?

Inorganic mercury compounds occur when mercury combines with elements such
as chlorine, sulfur, or oxygen.

These mercury compounds are also called mercury salts i.e. mercury chloride or
halides.

Mercury salts (mostly halides) are soluble in oil and gas condensate

Mercuric chlorides have a reasonably high solubility in organic liquids (about 10


times more than elemental mercury)

Most inorganic mercury compounds are white powders or crystals, except for
mercuric sulfide (also known as cinnabar) which is red and turns black after
exposure to light.

Why organic mercury compounds are the most toxic?

They can be chemically synthesized or biologically converted from mercury


compounds or bacteria e.g. methyl mercury.

Guide Book on Mercury Frequently Asked Questions

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Some organic mercury compounds are water soluble and bio-accumulated in the
food chain.

Most organic mercury compounds are extremely volatile liquids

How is the behavior of elemental mercury in solid, liquid and gaseous matrices?

Is being controlled by the high density, the low saturation vapor pressure and
high surface tension.

What is the use of mercury?

Mercury is used in a wide variety of products and processes


o thermometers, thermostats, barometers,
o electrical apparatus, cameras, cathode tubes (wiring, switches, batteries),
o paints
o pharmaceuticals
o production of some batteries
o dental amalgams
o mercury vapor lamps
o catalyst in production of urethane polymers for plastics
o cathode in electronic production of chlorine and caustic soda
o cosmetics industry as whitening agent

3. MERCURY HANDLING - SAFETY AT HOME


How to protect your children from metallic mercury?

Teach them not to play with shiny, silver liquids.

Schoolteachers (particularly science teachers) and school staff need to know about
students' fascination with metallic mercury.

Teachers and school staff should teach children about the dangers of getting sick
from playing with mercury, and they should keep metallic mercury in a safe and

Guide Book on Mercury Frequently Asked Questions

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secured area (such as a closed container in a locked storage room) so that children
do not have access to it without the supervision of a teacher

Metallic mercury evaporates slowly, and if it is not stored in a closed container,


children may breathe toxic mercury vapors.

Mercury containing medicines should be kept safely out of the reach of children
to prevent an accidental poisoning.

Non medicinal products, including some fungicides that contain mercury


compounds and paints that contain mercuric sulfide or mercuric oxide, should
also be safely stored out of the reach of children.

You should check to see if any medicines or herbal remedies that you or your
children use contain mercury. Some traditional Chinese and Indian remedies for
stomach disorders (for example, herbal balls) contain mercury, and if you give
these remedies to your children, you may harm them.

If you are pregnant or nursing a baby and you use mercury-containing ethnic or
herbal remedies, you could pass some of the mercury to your unborn child or
nursing infant

What are the household products and industrial items that bused metallic mercury?

Thermostats, fluorescent light bulbs, barometers, glass thermometers, and some


blood pressure measuring devices.

You must be careful when you handle and dispose of all items in the home that
contain metallic mercury

What if a thermometer breaks on a counter top or uncarpeted floor?

Remove children from the area. Mercury is not absorbent, so do not try to wipe or
blot it up with a cloth or paper towel; that will only spread the mercury and break
it up into smaller beads, making it more difficult to find and remove

Instead, clean up the beads of metallic mercury by using one sheet of paper to
carefully roll them onto a second sheet of paper, or by sucking very small beads
of mercury into an eye dropper.

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After picking up the metallic mercury in this manner, put it into a plastic bag or
airtight container. The paper and eye dropper should also be bagged in a zip-lock
plastic container.

All plastic bags used in the cleanup should then be taken outside of the house or
apartment and disposed of properly, according to instructions provided by your
local health department or environmental officials.

Try to ventilate the room with outside air, and close the room off from the rest of
the home. Use fans (that direct the air to the outside and away from the inside of
the house) for a minimum of one hour to speed the ventilation.

How do you clean spilled mercury at home?

Do not try to vacuum spilled metallic mercury. Using a vacuum cleaner to clean
up the mercury causes the mercury to evaporate into the air, creating greater
health risks.

Trying to vacuum spilled metallic mercury also contaminates the vacuum cleaner.

Also, take care not to step on the mercury and track it into other areas of the
home. Metallic mercury vapors are very toxic and have no odor.

Do not remain unnecessarily in that room, and try not to let metallic mercury
contact your eyes, skin, or clothing.

If you think you have been exposed directly to metallic mercury, wash yourself
thoroughly and discard contaminated clothing by placing them in a sealed plastic
bag.

Perhaps the most important thing to remember if you break a household


thermometer is do not panic. The amount of mercury contained in an oral
thermometer is small and does not present an immediate threat to human health.

However, if it is not properly cleaned up and disposed of, it may present a health
risk over time, particularly to infants, toddlers, and pregnant women

How do you deal with larger amount of metallic mercury spillage?

Regardless, do not vacuum

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Leave the area and contact your local health department and fire/rescue
department.

Do not simply throw metallic mercury away, but instead seek professional help

4. EFFECTS OF MERCURY TO CHILDREN AND FAMILY


How mercury can affect children?

Children are at risk of being exposed to metallic mercury that may be brought
home on work shoes, clothes or tools, or to methylmercury-contaminated foods

Methylmercury eaten or swallowed by a pregnant woman or metallic mercury that


enters her body from breathing contaminated air can also pass into the developing
child.

Inorganic mercury and methylmercury can also pass from a mother's body into
breast milk and into a nursing infant. The amount of mercury in the milk will
vary, depending on the degree of exposure and the amount of mercury that enter
the nursing woman's body.

What are other forms of exposure to children?

Children who had been exposed to excessive amounts of mercurous chloride


tablets for worms or mercurous chloride-containing powders for teething
discomfort had increased heart rates and elevated blood pressure

Children may be exposed to metallic mercury if they play with it

Children have also taken metallic mercury from school chemistry and physics
labs.

Broken thermometers and some electrical switches are other sources of metallic
mercury.

Sometimes children find containers of metallic mercury that were improperly


disposed of, or adults may bring home metallic mercury from work, not knowing
that it is dangerous.

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What are other symptoms of poisonings in children?

Those treated with mercurous chloride for constipation, worms, or teething


discomfort included swollen red gums, excessive salivation, weight loss, diarrhea
and/or abdominal pain, and muscle twitching or cramping in the legs and/or arms.

Children, who breathe metallic/elemental mercury vapors, eat foods or other


substances containing phenylmercury or inorganic mercury salts, or use mercurycontaining skin ointments for an extended period may develop a disorder known
as acrodynia, or pink disease.

What is pink disease or acrodynia?

Acrodynia can result in severe leg cramps; irritability; and abnormal redness of
the skin, followed by peeling of the hands, nose, and soles of the feet. Itching,
swelling, fever, fast heart rate, elevated blood pressure, excessive salivation or
sweating, rashes, fretfulness, steeplessness, and/or weakness may also be present

What other severe effects observed in children whose mothers were exposed to very
toxic levels of mercury during pregnancy?

Include eventual blindness, involuntary muscle contractions and seizures, muscle


weakness, and inability to speak.

It is important to remember, however, that the severity of these effects depends


upon the level of mercury exposure and the time of exposure.

What is the main source of exposure to methylmercury for the pregnant woman and
the young child?

From eating fish.

Since mercury accumulates in the muscles of fish, larger fish that feed on smaller
fish and live for long periods usually have larger concentrations of methylmercury
than fish that feed on plants. For example, shark and swordfish normally contain
the highest levels of mercury out of all ocean fish

Guide Book on Mercury Frequently Asked Questions

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How can families reduce the risk of exposure to mercury?

If your doctor finds that you have been exposed to significant amounts of
mercury, ask whether your children might also be exposed

Your doctor might need to ask your state health department to investigate

Some skin-lightening creams contain mercury, what are they?

Ammoniated mercuric chloride and mercuric iodide.

One way in which people are routinely exposed to extremely small amounts of
mercury is through the gradual (but extremely slow), what is it?

Wearing-away process of dental amalgam fillings, which contain approximately


50% mercury

However dental amalgam fillings do not pose a health risk, although they do account for
some mercury exposure to those having such fillings
5. ROUTES OF EXPOSURE
What are the routes of exposures?

Its either through:


o Inhalation of mercury vapor
o ingestion of ionic mercury
o dermal absorption of mercury

6. SIGNS AND SYMPTOMS OF EXPOSURE


What are the magnitudes of exposures?

Its either acute or chronic exposure

Guide Book on Mercury Frequently Asked Questions

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What governs exposure?

the period of time between exposure

the type of absorbed mercury species

magnitude of exposure

What is acute exposure and its symptoms?

Acute refers to exposure to high concentrations of mercury vapor which may


cause severe respiratory damage

Acute exposure periods is less than 15 days

Its symptoms as follow:


o chills, nausea, general malaise
o tightness in chest, chest pains
o dyspnea, cough, stomatitis
o gingivitis, salivation
o diarrhea

What is chronic exposure?

Chronic refers to exposure to lower levels of mercury concentration and is


primarily associated with central nervous system damage. Chronic exposure is
also associated with behavioral changes and alterations in peripheral nervous
system

Chronic exposure periods is 365 days or more

Its symptoms are as follow:


o psychological anomalies

excitability

memory loss

insomnia and

depression

o physical symptoms

Guide Book on Mercury Frequently Asked Questions

weakness, fatigue

anorexia, apathy, weight loss

flush, fever

skin exhibit abnormal blushing, dermographia

excessive sweating and irregular macular rashes

severe salivation and gingivitis

tremors may develop in more advanced cases

17

What are the most prominent symptoms associated with mercury vapor-induced
neurotoxicity?

the most prominent symptoms associated with mercury vapor-induced


neurotoxicity include the following:
o tremors initially affecting the hands and sometimes spreading to other
parts of the body
o emotional stability often referred to as erethism and characterized by
irritability, excessive shyness, confidence loss and nervousness
o insomnia
o neuromuscular changes weakness, muscle atrophy, muscle twitching
o headaches
o polyneuropathy parasthesias, stocking-glove sensory loss, hyperactive
tendon reflexes, slowed sensory and motor nerve conduction velocities
o memory loss and performance deficits in tests of cognitive function

For petroleum workers, which one is more infrequently encountered?

Acutely toxic environments (chronic exposures require years to manifest)

For petroleum workers like those doing maintenance works during shutdown or
turnaround especially jobs that involve hot works i.e. welding on pipes or steel, what
is the governing factor that affects mercury vapor concentration?

Guide Book on Mercury Frequently Asked Questions

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Temperatures play an important role that has direct impact on the release of
mercury vapor to atmosphere.

At temperatures of 30 - 40C, the vaporization rate of mercury is 3000 6000


times.

At temperatures of 60 - 80C the temperature of pipe or equipment, the


vaporization rate of mercury is 30,000 80,000 times

As an example, a two square inch surface of mercury exposed to air in a small


area can raise the mercury vapor level to 0.2 mg/m within 5 minutes

The vaporization rate of mercury doubles with every 10C temperature increase

Other than temperature, the concentration of mercury in air depends on what else?

A series of other conditions such as:


o known relationship established between concentrations of mercury vapors
o their distance from volatile surface of mercury

for example at the surface of 0.5m metallic mercury, air found above at a height
of 5 cm about the vaporizing surface contains 1.86 mg mercury vapor in one m,
at height of 30 cm, 1.26 mg, at height of 100 cm 0.85 mg mercury vapor

7. MERCURY RISKS EXPOSURE LIMITS


What are the exposure limits of mercury?

The exposure limits are as exhibited in table 4

Guide Book on Mercury Frequently Asked Questions

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Table 4: Mercury Risks Exposure Limits


Chemical

NIOSH
REL

ACGIH
TLV

metallic
mercury

DOSH
PEL
0.025
mg/m
TWA for up
to 8-hour
25g/m

OSHA
PEL

28 mg/m

NOTATION
Skin; A4
ACGIH

28,000
g/m
3.42 ppm

0.0031 ppm
0.01 mg/m

Alkyl (organo)
compounds
Aryl
(inorganic)
compounds
Mercury vapor

Mercury vapor

IDLH

0.1 mg/m

0.1 mg/m
of air as a
ceiling
limit
0.05 mg/m
as a TWA
for up to a
10-hour
workday and
40-hour
workweek

0.025 mg/m
as a TWA
for a normal
8-hour
workday
and a 40hour
workweek

Legend:

NIOSH REL - The National Institute for Occupational Safety and Health,
Recommended Exposure Limit (REL)

ACGIH TLV - The American Conference of Governmental Industrial Hygienists,


Threshold Limit Value (TLV)

DOSH PEL - Department of Occupational Safety and Health, Ministry of Human,


Resources Malaysia, Permissible Exposure Limit (PEL)

OSHA PEL - Occupational Safety and Health Administration, Permissible


Exposure Limit (PEL)

IDLH Immediately Dangerous to Life and Health

TWA - Time-weighted Average, in relation to airborne concentration means an


average airborne concentration over a specified period of time

mg/m - milligram per cubic meter of contaminated air

Guide Book on Mercury Frequently Asked Questions

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g/m - microgram per cubic meter of contaminated air

ppm parts of vapor or gas per million parts of contaminated air by volume

A4 ACGIH - A4 substance not classifiable as a human carcinogen (that can


produce cancer)

Skin skin designation indicates the potential for dermal absorption

8. IMPACT OF MERCURY TO HEALTH


Why are we concerned about mercury?

Mercury is a toxic persistent, bioaccumulative pollutant that affects the nervous


system.

Mercury and its compound are neurotoxins

Mercury can cause harmful effects to human, environment and processing


facilities

Why mercury is considered occupational hazards?

When someone is exposed to mercury vapor, elemental or metallic mercury is


readily absorbed into the blood stream via the lungs

The major inhalation scenarios are short duration inhalation of vapor having high
mercury concentration

A typical short duration situation is a welder who repairs or cuts pipes that has
mercury absorbed on the interior pipe wall

Here the vapor concentrations can be very high due to volatilization by the torch
or arc

Closed space atmospheres in equilibrium with elemental mercury deposits can


acquire mercury concentrations that exceeds 20 mg/m

The most common locations of mercury accumulation are separators and heat
exchangers

Mercury accumulates and concentrates in vessels and will produce interior vapor
concentrations much higher than in the process stream

Guide Book on Mercury Frequently Asked Questions

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Accumulation mechanisms include adsorption on equipment surfaces and


dissolution in sludge

What is the main source of mercury exposure for the general public?

The main source is organic mercury in the diet

How to minimize it and reduce the body burden?

Minimizing the consumption of mercury-laden fish and shellfish is an effective


means of reducing the body burden.

The amount of inhaled mercury vapor from accidental spills of metallic mercury
(e.g., from broken thermometers or electrical switches) can be minimized by
informing the general public of the potential dangers and volatility of liquid
mercury, and by prompt and thorough clean-up of liquid mercury spills.

For petroleum and petrochemical workers, what are mercury-specific hazards?

Health and safety of petroleum and petrochemical workers involve exposure to


mercury vapor and dermal absorption of dialkyl mercury

How can mercury affect my health?

The nervous system is very sensitive to mercury

Metallic mercury vapors or organic mercury may affect many different areas of
the brain and their associated functions, resulting in a variety of symptoms. These
include personality changes (irritability, shyness, nervousness), tremors, changes
in vision (constriction (or narrowing) of the visual field), deafness, muscle
incoordination, loss of sensation, and difficulties with memory. Permanent
damage to the brain has also been shown to occur from exposure to sufficiently
high levels of elemental or metallic mercury

Organic mercury compounds or methylmercury can caused permanent damage to


the brain and kidneys.

Guide Book on Mercury Frequently Asked Questions

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Inorganic mercury can damage the stomach and intestines, producing symptoms
of nausea, diarrhea, or severe ulcers if swallowed in large amounts

Following exposure and absorption, what happen to the mercury?

Metallic mercury is distributed primarily to the kidneys. Elemental mercury is


highly soluble in lipids and easily crosses cell membranes

Once in the blood, this form of mercury can distribute throughout the body, as
well as penetrate the blood-brain barrier, thus accumulating in the brain The body
burden half-life of metallic mercury is about 1-2 months

The kidney is also the primary organ of accumulation for compounds of inorganic
mercury, but the liver, spleen, bone marrow, red blood cells, intestine, and
respiratory mucosa are target tissues as well

Inorganic mercury is excreted primarily through the kidneys; its half-life ranges
from 42-60 days. As with elemental mercury, organic mercury compounds
accumulate throughout the body

Accumulation of organic mercury also occurs in the liver, where it is metabolized,


excreted through the bile, and often reabsorbed in the gastrointestinal tract

The half-life of lower alkyl mercurials is about 70-79 days

How is the mechanism of action of mercury that leads to toxic effects?

The majority of metallic mercury vapor and organic mercury absorbed by the
body is rapidly oxidized to the more toxic and soluble mercuric ion in the blood
and tissues through a hydrogen peroxide catalase pathway

It is believed that the high affinity of the cation for protein-containing sulfhydryl
or thiol groups is the underlying mechanism for the biological activity of mercury

In a process that is not yet completely understood, mercury disrupts the


intracellular sulfhydryl status, resulting in oxidative stress, followed by activation
of catabolic enzymes (i.e., proteases, endonucleases), and ultimately in cellular
injury

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Treatment with agents that reduce oxygen radical-producing reactions may be


effective in reducing mercury-induced oxidative cell damage

What are the challenges for reducing toxic effects?

In general, even the inorganic mercurials, that are considered to be more easily
chelated, are difficult to remove from the body and are not treated without some
side effects.

Infants and young children are particularly difficult to treat, sometimes requiring
exchange transfusion or other more elaborate measures

Reducing the body burden or toxic effects of mercury in pregnant women presents
an even greater challenge (i.e., treatment must be effective for both the mother
and the developing child), and specific treatment protocols are needed.

How to reduce peak absorption following exposure?

Strategies used to reduce absorption of mercury may differ depending on the route
of exposure and the specific chemical to which one is exposed.

Elemental mercury and certain organic forms of mercury have high vapor
pressures and are readily absorbed by the lungs; inhalation of these chemicals
may be the major exposure of concern. Because ingestion of most chemical forms
of mercury is possible, strategies for limiting absorption from the gastrointestinal
tract would be of utmost concern in such situations

The organic mercury compounds have greater absorption from the gut than
elemental and inorganic mercury; thus, strategies differ depending on the form of
mercury ingested

Dermal absorption of the various forms of mercury is also possible, so strategies


should also consider limiting dermal absorption

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What is the first step in mitigating the toxic effects of inhalation and dermal
exposures to mercury or its compounds?

Remove immediately from the contaminated area or source

Why different forms of mercury have different effects on the nervous system?

Because they do not all move through the body in the same way.

When metallic mercury vapors are inhaled, they readily enter the bloodstream and
are carried throughout the body and can move into the brain.

Breathing in or swallowing large amounts of methylmercury also results in some


of the mercury moving into the brain and affecting the nervous system.

Inorganic mercury salts, such as mercuric chloride, do not enter the brain as
readily as methylmercury or metallic mercury vapor.

Why the kidneys are also sensitive to the effects of mercury?

Because mercury accumulates in the kidneys and causes higher exposures to these
tissues, and thus more damage

9. IMPACT OF MERCURY TO ENVIRONMENT


How mercury behave in the environment?

Due to its chemical properties, environmental mercury is thought to move through


various environmental compartments, possibly changing form and species during
this process

Like other elements such as nitrogen, these movements are conceptualized as a


cycle

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Mercury cycles in the environment, what is it?

The depiction of the mercury cycle in Fig 1 illustrates mercury release by both
natural and anthropogenic sources into environmental media: air, soil and water

As indicated in this figure, mercury is emitted to the atmosphere by variety of


sources, dispersed and transported in the air, deposited to the earth, and stored in
or transferred between the land, water and air

Fig 1: The Biogeochemical Cycling of Elemental Mercury: Anthropogenic


Influences;Geochim Cosmochim.Acta, 58(15):3191-3198
How mercury is release to the environment?

Mercury occurs naturally as a mineral and is distributed throughout the


environment by both natural and anthropogenic processes

The natural global bio-geochemical cycling of mercury is characterized by


degassing of the element from soils and surface waters, followed by atmospheric

Guide Book on Mercury Frequently Asked Questions

26

transport, deposition of mercury back to land and surface water, and sorption of
the compound to soil or sediment particulates. Mercury deposited on land and
open water is in part revolatilized back into the atmosphere. This emission,
deposition, and revolatilization create difficulties in tracing the movement of
mercury to its sources

Major anthropogenic sources of mercury releases to the environment include


mining and smelting; industrial processes involving the use of mercury, including
chIor-alkali production facilities; combustion of fossil fuels, primarily coal;
production of cement; and medical and municipal waste incinerators and
industrial/commercial boilers

Sources of mercury which migrates to the environment is as illustrated in Fig 2,


through man-made discharges of industrial and domestic wastes, natural
discharges through leaching and volatilization of the geological formations
containing significant quantities of mercury such as volcanic fumaroles

Fig 2: Sources of Mercury Migrate to Aquatic Environment

Guide Book on Mercury Frequently Asked Questions

27

Mercury can take a myriad of pathways through the environment, how it cycles?

Figure 3 shows a schematic drawing of mercury in an aquatic ecosystem

The ultimate source of mercury to aquatic ecosystems is deposition from the


atmosphere, primarily associated with rainfall

As depicted in this figure, atmospheric deposition contains the three principal


forms of mercury, although the majority is an inorganic mercury (Hg2+, ionic
mercury)

Once in surface water, mercury enters a complex cycle in which one form can be
converted to another

It can be brought to the sediments by particle settling and then later released by
diffusion or resuspension

It can enter the food chain, or it can be released back to the atmosphere by
volatilization

Fig 3: Mercury Cycling In Aquatic Ecosystem (Lewis Publishers, CRC Press)

Guide Book on Mercury Frequently Asked Questions

28

How does mercury become a toxicological problem?

Like many environmental contaminants, mercury undergoes bioaccumulation

What is Bioaccumulation?

Bioaccumulation is the process by which organisms (including human) can take


up contaminants more rapidly than their bodies can eliminate them, thus the
amount of mercury in their body accumulates over time

What if for a period of time an organism does not ingest mercury?

Its body burden of mercury will decline

What if an organism continually ingests mercury?

Its body burden can reach toxic levels

For humans, how much body burden can be eliminated?

Burden of mercury can be eliminated in 70 days if no mercury is ingested during


that time

What is biomagnification?

Biomagnification is the incremental increase in concentration of a contaminant at


each level of a food chain

Guide Book on Mercury Frequently Asked Questions

29

How mercury biomagnifies in the food chain?

Mercury biomagnifies from the bottom to the top of the food chain as illustrated
in the figure 4:

Fig 4: Mercury biomagnifies from the bottom to the top of the food chain

As depicted in Fig 4, this phenomenon occurs because the food source for
organisms higher on the food chain is progressively more concentrated in mercury
and other contaminants, thus magnifying bioaccumulation rates at the top of the
food chain

Guide Book on Mercury Frequently Asked Questions

30

The bioaccumulation effect is generally compounded the longer an organism


lives, such that larger predator game fish will likely have the highest mercury
levels

Adding to this problem is the fact that mercury concentrates in the muscle tissue
of fish

How does mercury enter the food chain?

The exact mechanisms by which mercury enters the food chain remain largely
unknown and may vary among ecosystems

As depicted in Fig 5, mercury accumulates most efficiently in the aquatic food


web

Studies have shown that bacteria that process sulfate (SO4) in the environment
take up mercury in its inorganic form, and through metabolic processes convert it
to methylmercury

Guide Book on Mercury Frequently Asked Questions

31

Fig 5: Mercury Cycles in Aquatic Food Web

The conversion of inorganic mercury to methylmercury is important for two


reasons:
o Methylmercury is much toxic than inorganic mercury
o Organisms require considerably longer to eliminate methylmercury

Fish consumption dominates the pathway for human and wildlife exposure to
methylmercury

Predatory organisms at the top of the food web generally have higher mercury
concentrations

What is methylation?

Methylation is a product of complex processes that move and transform mercury

Guide Book on Mercury Frequently Asked Questions

32

What factors affect methylation?

Atmospheric deposition contains the three principal forms of mercury, although


inorganic divalent mercury (HgII) is the dominant form

Once in surface water, mercury enters a complex cycle in which one form can be
converted to another

Mercury attached to particles can settle onto the sediments where it can diffuse
into the water column, be resuspended, be buried by other sediments, or be
methylated

Methylmercury can enter the food chain, or it can be released back to the
atmosphere by volatilization

10. IMPACT OF MERCURY TO PRODUCT QUALITY, PROCESS


EQUIPMENT AND MATERIALS
What are the impacts of mercury to product quality?

Not meeting the sales/export specifications (off spec) either gas or oil or
condensate

Lower product value in terms of commercial may exposed to penalty or


demurrage

What are the impacts of mercury to process equipment and materials (metal)?

The various impacts are as follow:


o Equipment failures e.g. cold box, labyrinth etc
o Catalyst poisoning e.g. hydrogenation catalyst, metal catalyst etc
o Contaminated process units and products e.g. glycol dehydration system,
Acid Gas Removal Unit (AGRU)
o Potential explosion, likely to happen on ammonia plant

Guide Book on Mercury Frequently Asked Questions

33

What are the potential roots causes to the above impacts?

Equipment induced corrosion especially on aluminum and welded area, it can be


categorized under:

Liquid Metal Embrittlement (LME)

Amalgam Corrosion

Amalgamation

Galvanic Corrosion

Even though the mercury concentration in natural gas is low, does it pose a
concern?

Although the concentration of mercury in natural gas may be considered


extremely low, its cumulative effect can be serious

Elemental mercury forms amalgam with a variety of metals, what are they?

Elemental mercury forms amalgam with a variety of metals including aluminum,


copper, brass, zinc, chromium, iron and nickel

When these amalgams form with metal components of processing equipment, it


results in corrosion of the equipment

How aluminum corrosion does take place?


The most widely accepted theory of corrosion by mercury takes place in this sequence:

The mercury-aluminum amalgam process removes the oxide layer

The amalgams are weaker than the mercury-free metal or in this case with the
aluminum amalgam, it reacts with moisture to form metal oxide plus free mercury
which can accelerate the corrosion process

Guide Book on Mercury Frequently Asked Questions

34

What are the effects of corrosion by organic mercury Dimethylmercury (DMM)?

The effect of the DMM on the corrosion of carbon steel and aluminum metal was
rather frightening as compared to that of elemental mercury or mercuric chloride,
which is well-known as a severely corrosive agent

Studies revealed that DMM in methanol or petroleum ether as solvent gave


similar corrosion patterns to the elemental Hg solution

The higher DMM concentration or the higher reaction temperature, the more
severe corrosion occurred because of the higher elemental Hg concentration
generated

Trace amount of hydrogen chloride or hydrogen sulfide, which is also present in


large quantity in natural gas, remarkably increased the corrosion potential of
DMM on metal

Corrosion rate was approximately 700 times faster than the one containing only
DMM and 40 times faster than the one containing only acid

11. MEDICAL SURVEILLANCE


What is medical surveillance?

Monitoring of a person for the purpose of identifying changes in health due to the
occupational exposure to chemical or contaminants hazardous to health

What are the requirements of medical surveillance?

All PETRONAS employees and contractors personnel are required to undergo


pre-shift urine test one day before mobilization to work locations.

All PETRONAS employees and contractors personnel are required to undergo


post-shift blood test after returning to base on immediate basis.

All tests are to be conducted by an Occupational Health Doctor or Authorized


Medical Examiner (AME) approved by PETRONAS Corporate HSE.

All biological samples are to be analyzed by laboratory approved by PETRONAS


Corporate HSE.

Guide Book on Mercury Frequently Asked Questions

35

All health surveillance records are to be kept by respective employer for baseline
and future reference for a minimum of 30years

What are biological samples?

Refers to urine and blood

What is Biological Tolerance Limits (BTL)?

The permissible allowable limits

What is pre-shift urine?

Urine sample taken a day before going to work premises

What is post-shift blood?

Blood sample taken as soon as returning to base (immediate)

Who is Authorized Medical Examiner?

A medical practitioner who has undergone training in occupational health from a


recognized institution and is registered with the Department of Occupational
Safety and Health (DOSH). In PETRONAS such doctors are appointed as
Approved Medical Examiners (AMEs).

Why medical surveillance is important to employers?

To determine whether employers whose employees are exposed to mercury are


required to implement medical surveillance procedures

Guide Book on Mercury Frequently Asked Questions

36

How is it being implemented?

Medical Screening Workers who may be exposed to mercury hazards should be


monitored in a systematic program of medical surveillance that is intended to
prevent occupational injury and disease

The program should include the following:


o Education of employers and workers about work-related hazards
o Early detection of adverse health effects
o Referral of workers for diagnosis and treatment

If there is occurrence of mercury disease or work-related adverse health effects,


what should you do?

Take immediate evaluation of primary preventive measures e.g. industrial hygiene


monitoring, engineering controls and personal protective equipment

A medical surveillance is intended to supplement, not replace such measures

What should you do to detect and control work-related health effects?

To perform medical evaluations:


o Before job placement
o Periodically during the term of employment
o At the time of job transfer or termination

What are the medical evaluations of pre job placement?

Before a worker is placed in a job with a potential for exposure to mercury, to


conduct the following:
o An authorized Medical Examiner (AME) should examine the workers
baseline health status with:
thorough medical, environmental and occupational histories
physical examination

Guide Book on Mercury Frequently Asked Questions

37

physiologic and laboratory appropriate tests for the anticipated


occupational risks, function and integrity of
9 eyes
9 skin
9 respiratory system
9 central and peripheral nervous system
9 kidneys
What are periodical medical evaluations for the term of employment?

Occupational health interviews and physical examinations should be performed at


regular intervals during the employment period according to statutory standard

Where no standard exists and the hazard is minimal, evaluations should be


conducted every 3 to 5 years or as frequently recommended by an experienced
occupational health physician

Additional examinations may be necessary if a worker develops symptoms


attributable to mercury vapor exposure

The interviews, examinations and medical screening tests should focus on


identifying the adverse effects of mercury vapor on the
o eyes
o skin
o respiratory system
o kidneys

current health status should be compared with the baseline health status of the
individual worker or with expected values for suitable reference population

What is a termination medical evaluation?

The following should be repeated at the time of job transfer or termination to


determine the workers medical status at the end of the employment period:
o medical, environmental and occupational history interviews,

Guide Book on Mercury Frequently Asked Questions

38

o physical examination and selected physiologic or laboratory tests that


were conducted at the time of placement

Any changes in the workers health status should be compared with those
expected for suitable reference population

What is Biological Monitoring?

Biological Monitoring involves sampling and analyzing body tissues or fluids to


provide an index of exposure to a toxic substance or metabolite

Is there a medical test to determine whether I have been exposed to mercury?

There are reliable and accurate ways to measure mercury levels in the body

These tests all involve taking blood, urine, or hair samples, and must be
performed in a doctor's office or in a health clinic or Approved Medical
Examiners (AME)

Nursing women may have their breast milk tested for mercury levels, if any of the
other samples tested are found to contain significant amounts of mercury

Normally urine and blood or hair samples are biomarkers of exposure and effect
why?

Hair, blood, hair and urine levels are used as markers to determine whether
someone has been exposed to mercury

They are used to determine whether exposure to mercury has occurred and to give
a rough idea of the extent of exposure, but they do not tell exactly how much
exposure has occurred

Levels found in blood, urine, and hair may be used together to predict possible
health effects that may be caused by the different forms of mercury

Guide Book on Mercury Frequently Asked Questions

39

Where the biological samples send for analysis?

Send to approved laboratory that conduct the biological samples whereby the
clinical procedures and analytical methods are recognized by PETRONAS
Corporate HSE

What is the Biological Exposure Index (BEI) of Urine and Blood?


The Biological Exposure Index (BEI) of urine and blood are as exhibited in table 3
Table 3: Biological Exposure Index (BEI) of Urine and Blood
METABOLITE

NIOSH
REL

ACGIH
TLV

DOSH

OSHA

REMARKS

Urine

35 g/g
creatinine

Pre-shift sampling
Total inorganic
mercury

Blood

15g/L

Post-shift sampling
Total inorganic
mercury

What is the frequency of medical surveillance i.e. monitoring of biological samples?

The frequency of monitoring is every 6 months for permanent or regular


offshore/onshore personnel

What are biomarkers?

Biomarkers are broadly defined as indicators signaling events in biological


systems or samples

They have been classified as markers of exposure, markers of effect, and markers
of susceptibility

Guide Book on Mercury Frequently Asked Questions

40

What is biomarker of exposure?

A biomarker of exposure is a xenobiotic substance or its metabolite( s), or the


product of an interaction between a xenobiotic agent and some target molecule(s)
or cell(s), that is measured within a compartment of an organism

The preferred biomarkers of exposure are generally the substance itself or


substance-specific metabolites in readily obtainable body fluid(s) or excreta

The body burden of a substance may be the result of exposures from more than
one source.

The substance being measured may be a metabolite of another xenobiotic


substance (e.g., high urinary levels of phenol can result from exposure to several
different aromatic compounds)

Depending on the properties of the substance (e.g., biological half-life) and


environmental conditions (e.g., duration and route of exposure), the substance and
all of its metabolites may have left the body by the time samples can be taken

What are biomarkers of effect?

Biomarkers of effect are defined as any measurable biochemical, physiological, or


other alteration within an organism that, depending on magnitude, can be
recognized as established or potential health impairment or disease Note that
these markers are not often substance specific.

This definition encompasses biochemical or cellular signals of tissue dysfunction


(e.g., increased liver enzyme activity or pathological changes in female genital
epithelial cells), as well as physiological signs of dysfunction such as increased
blood pressure or decreased lung capacity

What is biomarker of susceptibility?

A biomarker of susceptibility is an indicator of an inherent or acquired limitation


of an organism's ability to respond to the challenge of exposure to a specific
xenobiotic substance.

Guide Book on Mercury Frequently Asked Questions

41

It can be an intrinsic genetic or other characteristic or a pre-existing disease that


results in an increase in the absorbed dose, a decrease in the biologically effective
dose, or a target tissue response.

What is the purpose to test urine?

Mercury in urine is used to test for exposure to metallic mercury vapor and to
inorganic forms of mercury

It is a more appropriate marker of inorganic mercury, because organic mercury


represents only a small fraction of urinary mercury

Analysis of urine is a better indicator of metallic mercury inhalation exposure


than is analysis of total mercury in blood

What is the purpose to test blood?

Measurement of mercury in whole blood is used to monitor exposure to


methylmercury

Blood is considered useful if samples are taken within a few days of exposure.
This is because most forms of mercury in the blood decrease by one-half (halflife) every three days if exposure has been stopped.

Thus, mercury levels in the blood provide more useful information after recent
exposures than after long-term exposures.

What is the purpose to test hair?

Hair is a biomarker of long-term exposure to methylmercury.

Once mercury is incorporated into hair, it remains unchanged

Hair can be used to show exposures that occurred many months ago, or even more
than a year ago if the hair is long enough and careful testing methods are used

Guide Book on Mercury Frequently Asked Questions

42

Is there any correlation between mercury in blood and urine?

Several studies have reported a correlation between mercury in blood and urine;
however, results vary, and it is not known whether the ratio between
concentrations in urine and blood remains constant at different exposure levels

Is there any correlation between amount of fish consumed and level of mercury in
hair?

A fairly strong correlation has been demonstrated by studies between the amount
of fish consumed, the level of mercury in the fish, and the level of mercury in hair

Is there any correlation between hair mercury levels with total intake levels and
with organ specific levels of mercury?

That hair mercury levels were highly significantly correlated with organ Hg levels
in the cerebrum, cerebellum, heart, spleen, liver, kidney cortex, and kidney
medulla, when the total mercury or methylmercury value in the organ was
compared with the hair total mercury or organic mercury, respectively.

Can expired air samples been considered as possible biomarkers of exposure for
mercury?

Following inhalation of metallic mercury vapor, some of the mercury may be


eliminated in the expired air, but excretion from this pathway is negligible 5-7
days after exposure

Thus, expired air as a measure of mercury exposure can only be used soon after
short-term exposure to mercury vapor

What is Medical Removal Protection?

Part of medical surveillance program, a process whereby a worker who has been
detected to have an abnormal condition or tests associated with exposures to an

Guide Book on Mercury Frequently Asked Questions

43

occupational hazard is placed in another work activity where such hazard is


minimal or absent
What is the intent of Medical Removal Protection (MRP)?

MRP is part of the medical surveillance program and is a legal requirement. It is


to be conducted by a medical doctor who has undergone training in occupational
health from a recognized institution and is registered with DOSH.

The purpose is to provide guideline for the management in the event of an


employee (PETRONAS or Contractor) to be removed and isolated from any work
that the medical finding by an occupational health doctor has detected medical
condition which places him/her at increased risk of impairment to health from
exposure to chemical or contaminants hazardous to health.

It cover all cases exhibiting signs and symptoms associated with mercury
poisoning:
o all cases suspected of poisoning such as evident of over exposure
(airborne mercury exceeding 10% of permissible exposure level, PEL)
o evident of mercury ingestion or prolong contact
o raised urine mercury, above 35 g/g creatinine pre-shift
o raised blood mercury, above 15 g/L taken immediately post-shift

Medical Removal Protection positive cases (levels above normal limits) should
be removed from any work place and urinary creatinine monitored monthly till
the levels are below 35 g/g.
o Examining occupational health doctor should include central nervous
system and other relevant medical test related to mercury toxicity
particularly to target organs.
o These examination results should be furnished along with blood and urine
results if the levels are above normal limits or on routine medical
examination otherwise.

Guide Book on Mercury Frequently Asked Questions

44

Reinstatement - medical removal protection is in place unless the abnormal


medical condition has normalized.

12. TREATMENT TO MERCURY EXPOSURE


Are there methods for reducing toxic effects?

Although there are a number of treatments currently available, none are


completely satisfactory and additional development of treatment drugs and
protocols is needed.

When specific exposures have occurred, poison control centers and medical
toxicologists should be consulted for medical advice.

Several treatments have been suggested to reduce absorption of mercury from the
gastrointestinal tract, what are they?

Most refer to the inorganic forms of mercury

It is likely that strategies that are effective in reducing the absorption of inorganic
forms may also have some efficacy for organic forms

Several procedures that have been recommended for trapping mercury in the
gastrointestinal tract are based on the mercury's affinity for binding to sulfhydryl
groups. For example, oral administration of a protein solution (e.g., milk or egg
whites) has been suggested to reduce absorption (Gosse 1 and Bricker 1984;
Haddad and Winchester 1990; Stutz and Janusz 1988)

Salt-poor albumin administration has also been suggested (Haddad and


Winchester 1990).

Non absorbable agents (e.g., polystyrene resins containing sulfhydryl groups)


have been used to decrease the absorption rate of methylmercury (Clarkson et al.
1973).

Note: Some of the treatments discussed may be experimental and unproven; this
should not be used as a guide for the treatment of exposures to mercury. When specific

Guide Book on Mercury Frequently Asked Questions

45

exposures have occurred, poison control centers and medical toxicologists should be
consulted for medical advice
Any other suggested treatments?

The oral administration of activated charcoal has also been suggested (Gossel and
Bricker 1984; Stutz and Janusz 1988). Rapid removal of mercury from the
gastrointestinal tract may be indicated in some acute, highdose situations. In such
situations, immediate emesis or gastric lavage has been suggested (Goldfrank et
al. 1990; Haddad and Winchester 1990).

Inclusion of salt-poor albumin or sodium formaldehyde sulfoxylate in the lavage


fluid to convert the mercuric ion into the less soluble mercurous ion in the
stomach has also been recommended (Haddad and Winchester 1990).

A saline cathartic, such as magnesium sulfate, to speed removal from the


gastrointestinal tract has also been recommended unless diarrhea has already
begun (Haddad and Winchester 1990; Stutz and Janusz 1988).

Giving CaNa2-EDTA is contraindicated because it binds poorly to mercury, may


be toxic to the kidneys, chelates other essential minerals, and may cause
redistribution of mercury in the body (Gossel and Bricker 1984).

Note: Some of the treatments discussed may be experimental and unproven; this
should not be used as a guide for the treatment of exposures to mercury. When specific
exposures have occurred, poison control centers and medical toxicologists should be
consulted for medical advice.
What is the treatment of choice for reducing the body burden of mercury?

Chelation therapy is presently the treatment of choice

There are currently a number of chelators, what are they?

These chelators differ in their efficacy for various forms of mercury, routes of
administration, side effects, and routes of excretion. Depending on the chemical to

Guide Book on Mercury Frequently Asked Questions

46

which one has been exposed and the health status of the individual, different
chelators may be indicated.

One popularly used chelator, dimercaprol or BAL, has two sulfhydryl groups that
can bind mercury and compete with its binding to sulfhydryl groups in body
tissues. This chelator is preferred when renal impairment has occurred

Another currently used mercury chelator is D-penicillamine. This drug has been
used somewhat effectively to reduce the toxicity of elemental and inorganic
mercury exposures

N-acetyl-D,L-penicillamine (NAP) is another chelator, to treat victims of mercury


inhalation

Dimercaptosuccoinic acid (DMSA), an effective chelator for both inorganic and


methylmercury

Dimercaptopropane-I-sulfonate (DMPS) is another BAL analogue that is an orally


effective chelator for mercury

Other than the above chelators, what else to treat mercury poisoning?

Hemodialysis with infusion of a chelator (cysteine, N-acetylcysteine, NAP) has


been reported to be effective in some severe cases of poisoning where renal
failure is a complication (Berlin 1986; Goldfrank et al. 1990; Haddad and
Winchester 1990)

13. ANALYTICAL METHODS


Analytical methods that are available for detecting, and/or measuring, and/or
monitoring mercury, its metabolites, and other biomarkers of exposure to and
effects of mercury, normally approved by who?

Many of the analytical methods used for environmental samples are the methods
approved by federal agencies and organizations such as EPA and the National
Institute for Occupational Safety and Health (NIOSH)

Guide Book on Mercury Frequently Asked Questions

47

Other methods are those that are approved by groups such as the Association of
Official Analytical Chemists (AOAC) and the American Public Health
Association (APHA)

What are the methods used for biological materials?

To determine mercury levels in the blood, urine, tissues, and hair of humans and
animals, methods that have been used are:
o atomic absorption spectrometry (AAS)
o atomic fluorescence spectrometry (AFS)
o neutron activation analysis (NAA)
o inductive couple plasma (ICP)

In addition, methods based on mass spectrometry (MS), spectrophotometry, and


anodic stripping voltametry (ASY) have also been tested

Base on the available methods, which method is widely used?

Cold Vapor (CV) AAS is the most widely used

In most methods, mercury in the sample is reduced to the elemental state

14. References
ACGIH. 1996. Threshold limit values for chemical substances and physical agents and biological
exposure indices for 1996. American Conference of Governmental Industrial Hygienists,
Cincinnati, OH.
Adinolfi M. 1985. The Development of the Human Blood-CSF-Brain Barrier. Developmental
Medicine & Child Neurology 27:532-537
Afonso J, deAlvarez R. 1960. Effects of mercury on human gestation. Am J Obstet Gynecol
80:145-154
Ahmed R, Duerbeck HW, Stoeppler M, et al. 1988. Gas liquid chromatographic (GLC) analysis
of methylmercury in fish and its comparison with total mercury. Pak J Sci Ind Res 31(8):535-540
Airey D. 1983a. Mercury in human hair due to environment and diet: a review. Environ Health
Perspect 52:303-316

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Al-Saleh I, Al-Doush I. 1997. Mercury content in skin-lightening creams and potential hazards to
the health of Saudi women. J Toxicol Environ Health 51(2):123-30
Al-Shahristani H, Shihab K. 1974. Variation of biological half-time of methylmercury in man.
Arch Environ Health 18:342-352
Al-Shahristani J, Shihab KM, Al-Haddad JK. 1976. Mercury in hair as an indicator of total body
burden. Bull World Health Organ (Suppl) 53:105-112
Albers JW, Kallenbach LR, Fine LJ, et al. 1988. Neurological abnormalities associated with
remote occupational elemental mercury exposure. Ann Neurol 24(5):651-659
Alcser KH, Birx KA, Fine LJ. 1989. Occupational mercury exposure and male reproductive
health. Am J Ind Med 15(5):517-529
Andren AW, Nriagu JO. 1979. The global cycle of mercury. In: Nriagu JO, ed. The
biogeochemistry of mercury in the environment. New York, NY: Elsevier/North Holland
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Anwar WA, Gabal MS. 1991. Cytogenetic study in workers occupationally exposed to mercury
fulminate. Mutagenesis 6(3):189-192
Aschner M, Aschner JL. 1990. Mercury neurotoxicity: Mechanisms of blood-brain barrier
transport. Neurosci Biobehav Rev 14(2):169-176
ATSDR. 1989. Decision guide for identifying substance-specific data needs related to
toxicological profiles. Agency for Toxic Substances and Disease Registry, Division of
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for
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Expert Panel Review of the Toxicological Profile for Mercury
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Bloom NS, Fitzgerald WF. 1988. Determination of volatile mercury species at the picogram level
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Bornhausen M, Musch MR, Greim H. 1980. Operant behavior performance changes in rats after
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Bradberry SM, Feldman MA, Braithwaite RA, et al. 1996. Elemental mercury-induced skin
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Bronstein AC, Currance PL. 1988. Emergency care for hazardous materials exposure.
Washington, DC: The C.V. Mosby Company, 183-184
Buchet J, Roels H, Bernard A, et al. 1980. Assessment of renal function of workers exposed to
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15. GLOSSARY
AbsorptionThe taking up of liquids by solids, or of gases by solids or liquids
Acute ExposureExposure to a chemical for a duration of 14 days or less, as specified in the
Toxicological Profile
AdsorptionThe adhesion in an extremely thin layer of molecules (as of gases, solutes, or
liquids) to the surfaces of solid bodies or liquids with which they are in contact
Biomarkersare broadly defined as indicators signaling events in biologic systems or samples.
They have been classified as markers of exposure, markers of effect, and markers of susceptibility
CarcinogenA chemical capable of inducing cancer
Ceiling ValueA concentration of a substance that should not be exceeded, even
instantaneously
Chronic ExposureExposure to a chemical for 365 days or more, as specified in the
Toxicological Profiles
Data Needssubstance-specific informational needs that if met would reduce the uncertainties
of human health assessment
Developmental ToxicityThe occurrence of adverse effects on the developing organism that
may result from exposure to a chemical prior to conception (either parent), during prenatal
development, or postnatally to the time of sexual maturation. Adverse developmental effects may
be detected at any point in the life span of the organism
Dose-Response Relationshipthe quantitative relationship between the amount of exposure to a
toxicant and the incidence of the adverse effects
Half-lifea measure of rate for the time required to eliminate one half of a quantity of a
chemical from the body or environmental media
Immediately Dangerous to Life or Health (IDLH)The maximum environmental
concentration of a contaminant from which one could escape within 30 minutes without any
escape-impairing symptoms or irreversible health effects
Intermediate ExposureExposure to a chemical for a duration of 15-364 days, as specified in
the Toxicological Profiles
Immunologic ToxicityThe occurrence of adverse effects on the immune system that may
result from exposure to environmental agents such as chemicals
NeurotoxicityThe occurrence of adverse effects on the nervous system following exposure to a
Chemical

Guide Book on Mercury Frequently Asked Questions

57

Permissible Exposure Limit (PEL)An Occupational Safety and Health Administration


(OSHA) allowable exposure level in workplace air averaged over an 8-hour shift of a 40 hour
workweek
Pharmacokineticsis the science of quantitatively predicting the fate (disposition) of an
exogenous substance in an organism. Utilizing computational techniques, it provides the means of
studying the absorption, distribution, metabolism and excretion of chemicals by the body
Recommended Exposure Limit (REL)A National Institute for Occupational Safety and
Health (NIOSH) time-weighted average (TWA) concentrations for up to a 10-hour workday
during a 40-hour workweek
Riskthe possibility or chance that some adverse effect will result from a given exposure to a
chemical
Risk FactorAn aspect of personal behavior or lifestyle, an environmental exposure, or an
inborn or inherited characteristic, that is associated with an increased occurrence of disease or
other health-related event or condition
Risk RatioThe ratio of the risk among persons with specific risk factors compared to the risk
among persons without risk factors. A risk ratio greater than 1 indicates greater risk of disease in
the exposed group compared to the unexposed
Short-Term Exposure Limit (STEL)The American Conference of Governmental Industrial
Hygienists (ACGIH) maximum concentration to which workers can be exposed for up to 15 min
continually. No more than four excursions are allowed per day, and there must be at least 60 min
between exposure periods. The daily Threshold Limit Value - Time Weighted Average (TLVTWA) may not be exceeded
Threshold Limit Value (TLV)An American Conference of Governmental Industrial
Hygienists (ACGIH) concentration of a substance to which most workers can be exposed without
adverse effect. The TLV may be expressed as a Time Weighted Average (TWA), as a Short-Term
Exposure Limit (STEL), or as a ceiling limit (CL)
Time-Weighted Average (TWA)An allowable exposure concentration averaged over a
normal 8-hour workday or 40-hour workweek
ToxicokineticThe study of the absorption, distribution and elimination of toxic compounds in
the living organism
Xenobioticany chemical that is foreign to the biological system

16. ACRONYMS, ABBREVIATIONS


ACGIH
ATSDR
ATSDR
CL
CNS
DOSH
EPA

American Conference of Governmental Industrial Hygienists


Agency for Toxic Substances and Disease Registry
Agency for Toxic Substances and Disease Registry
ceiling limit value
central nervous system
Department of Safety and Health
Environmental Protection Agency

Guide Book on Mercury Frequently Asked Questions

IDLH
NIOSH
OSHA
PEL
ppb
ppm
ppt
REL
STEL
TLV
TWA

Immediately Dangerous to Life and Health


National Institute for Occupational Safety and Health
Occupational Safety and Health Administration
permissible exposure limit
parts per billion
parts per million
parts per trillion
recommended exposure level/limit
short-term exposure limit
threshold limit value
time-weighted average

58