DRUG MECHANISME AND CLINICAL USED

N
O

DRUGS

MECHANISM OF ACTION

TOXICITY

1

Albendazol

Unclear
To block glucose uptake (larva-adult
worm) decrease formation of ATP
To inhibit to microtubule assembly

short therapy
A few toxic effect, may
reversible :leukopenia,
alopecia
Long-term therapy
Change in liver enzyme
Bone marrow suppression
and fetal toxicity (animal)
CI : Pregnancy

2

Mebendazol

Selectively inhibiting microtubule
synthesis and glucose uptake

Limited to GIT iritation
Embriotoxicity
(teratogenic)

Note: <10% is absorbed systemically
(oral)  to be metabolized rapidly

N
O

DRUGS

MECHANISM OF ACTION

TOXICITY

CLINICAL USED
Wide anthelmintic
spectrum
 Larva migran
(ancylostoma sp)
 Ascariasis
 Roundworm
 Whipworm,
threadworm
 Hookworm,
pinworm
 cysticercosis
Drug of choice for
PINWORM,
Roundworm,
hookworm and
WHIPWORM
Combined with
pyrantel pamoate 
ascarids and
hookworm

CLINICAL USED

intrahepatic cholectasis Rx cause by dying parasites  fever. weakness Precaution :  Liver disfunction SGOT >  Pregnancy. roundworm Alternative drug for Ascariasis TOXICITY CLINICAL USED Fever. tachycardia. chills. headache. cutaneus larvamigran. muscle and lymp gland (short Drug of choice for strongyloidiasis. headache. headache. Onchocerca volvulus. hematuria. pinworm. lymphadenophaty. pruritus. skin rush Ci : Children (BW < 15kg). Liver and kidney disfunction MINOR GI distress. dizzines. rashes. leucopenia. dizzines. hypotension. threadworm (Strongyloides stercoralis) Drug of choice for hookworm. liver and kidney dysfuction Drug of Choice for visceral form  strongyloidiasis. drowsiness.3 Thiabendazol Similar with mebendazole Notes :  Rapidly absorbed from the gut  Metabolized by liver enzym  Has anti-inflamatory in host 4 Pyrantel pamoate 5 Piperazine N O DRUGS 6 Ivermectine Stimulate nicotinic receptor (neuromuscular junction) muscle contraction  depolarization induce paralysis Notes :  poorly absorbed from the gut Against at GABA receptors paralyzed MECHANISM OF ACTION Intensifies GABA mediated neurotransmission  causes immobilization of parasites GIT iritation. Alternative drug for . Children < 2 y Mild GIT Iritation CI : Epileptique Seizures. pain in joint.

anorexia Increase their susceptibility to Rx caused by protein release host defense mechanism (dying filariae) fever. ocular damage. Can be controled by more readly than adult antihistamine and AINS worm filariasis Drug of choice for FILARIASIS Be combined with suramin for ONCHOCERCIASIS Alternative for larva migrans .7 Diethylcarbam azine duration) Can be controled by antihistamine and AINS CI : Pregnancy Don’t be combined with barbiturate. benzodiazepine and valproic acid Imobilizes microfilariae Headache.  Microfilariae are killed pyrexia. respiratory distress. (unknown) weakness.  Rapidly absorbed from the lymphadenitis gut In Onchocerciasis  The  Excreted via urine Mazzotti Rx : hypotension. malaise. rashes. joint Notes : and muscle pain.