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Biology XII (Notes)

Arranged By: Faisal Ahmed Jokhio

Faisal Ahmed Jokhio

Keep In Mind That Time Always Take Their Revenge
So, Dont waste Ur Precious Time Otherwise it will take their Revenge
By Wasting Your Beautiful Life.
-Faisal Ahmed Jokhio

Biology XII (Notes)

Arranged By: Faisal Ahmed Jokhio

Feed Back System
Osmoregulation In Terrestial Animals
Osmoregulation In Aquatic Animals
Osmoregulation In Marine Animals
Excretion In Animal
Excretion In Hydra
Excretion In Planaria
Excretion In Cockroach
Urinary System In Human Being
Functions of Kidney
Reabsorbtion In Nephron
Effects Of Hormones on Working of Kidney
Kidney Problems
Treatment of Kidney Failure
Poikilotherms (Cold Blooded)
Homeotherms (Warm Blooded)
Modern Classification Of Animals
Method Of Thermoregulation in Animals
Role Of Brain In Thermoregulation
Chromosomes as Carrier of Genes
Chromosomal Theory of Heredity
Fredrick Griffiths Experiment
Macleod and McCartys Experiment
Hershey and Chases Experiment
Watson and Cricks Model Of DNA
Genes-The Unit of Hereditary Information
Replication Of DNA
Biology XII (Notes)

Arranged By: Faisal Ahmed Jokhio

Semi Conservative Replication
The Meselson Stahl Experiment
One Gene On Enzyme Hypothesis
Support In Plants
Movement In Plant
Human Skeleton
Types Of Skeleton
Bones And Cartillages
Deformities Skeleton
Muscular System
Structure of Skeleton Muscles
Structure Of Actin
Sliding Filament Theory
Cross Bridge Theory
Controls Of Muscle Contraction
Abnormal Muscle Contraction
Antagonisitic Muscles
Locomotion In Protozoa
Locomotion In Animals
Plant Hormones
Responses To Environmental Stress
Defence Against Pathogens
Biological Clocks
Circadian Rhythms
Nervous Tissues
Reflex Actin
Reflex Arc
Nerve Impulse
Resting Membrane Potential
Biology XII (Notes)


Arranged By: Faisal Ahmed Jokhio

Action Potential
Evolution Of Nervous
Central Nervous System
Peripheral Nervous System
Brain Stem
Spiral Cord
Spinal Nerves
Nervous Disorders
Chemical Co-Ordination
Types Of Hormones
Hormone Action
Functions Of Hormones
Endocrine System
Endocrine Glans Of Man
Pituitary Gland
Thyroid Gland
Parathyroid Gland
Adrenal Gland
Thymus Gland
Pineal Gland


Biology XII (Notes)

Arranged By: Faisal Ahmed Jokhio

Home means same and statis means state. So the regulatory mechanism which
maintained the internal environment of a organism is called homeostatis.

Important Aspects of Homeostatis

There are three important aspects of homeostatis.



Feed Back System

The check and balance system in a body is called feed back system. In a feed back
system three organs are involved.

1. Receptor
The organ which receive any change in the internal environment of the body are
called Receptor.

2. Effector
The central nervous system which send the message to a particular organ are called
effector. Take part in particular action.

3. Central Nervous System

The receptor transfer message to a central nervous system such as brain.

Types of Feed Back System

There are two type of feed back system.
Positive Feed Back System

Negative Feed Back System

1. Positive Feed Back System

When there is a change in the internal environment and it is further increase
by the process are called positive feed back system.

2. Negative Feed Back System

When there is a change in the internal environment and it is further
decreased by the process called negative feed back system.

3. Osmoregulation

The regulatory mechanism which maintain the balance between water and
solute context of a cell is called osmoregulation.

Osmoregulation in Plant
Due to the availability of water there are four groups of plant.




The group of plant which is grow in fresh water are called hydrophyte.

Characteristic of Hydrophyte

The plant do not have layer of cuticle.

The leave have stomata in the upper surface with take part in transpiration.

The root are either absent or poorly developed.

Hydrilla, Lotus, Lily plant

The group of plant which is grow in marshy soil or salty soil are called halophyte.

Characteristic of Halophyte

These plant absorb water from such a soil, which is higher salt concentration
and low water potential.

Halophyte actively absorption salt into their roots.

In the leaves of plants salt glands are present which helps in the removal of
salt and water from the body.

Some halophytes absorb humidity by leave.

Glass wort, Cord grass

The group of plant which is grow in well watered soil are called mesophyte.

Characteristics of Mesophyte

Their roots are well developed.

Their body is covered by a layer called cuticle.

They contain stomata for evaporation of extra water.

Some mesophyte excrete out water in the form of drop this process is called

The group of plant which is grow in dry places such as desert are called Xerophyte.

Characteristic of Xerophyte

Some plants do not face dry consition and produce seed are called ephemeral
plant. During raining season seeds germinate.

Their root are well develop which go deep into the soil to absorb water.

Some plant have horizontal root on the surface to absorb rain water rapidly.

Some plant leaves are modified into spine to prevent transpiration.

Stem and leave covered by cuticle.

Some plant store water in cell (succulent)

Cacuts, Euphorbia.

The removal of harmful substance produce in the metabolic process from the body
is called Excretion.

Excretion in Plant

In plant rate of catabolic process is very slow and waste product are produce in less
amount. They are used again in their anabolic process.

Waste Substance of Plant

The substance which are produce in excess amount are

CO2 and O2


Removal of Water
Extra water is removed from the body of plant by two methods.

The extra amount of water removed in the form of vapor through stomata is called
When water is removed from plant in the form of drop this process is called
Guttation. Guttation occur special opening called hydathods. Guttation take place in
those plant which grow in tropical rain forest.

Release of Oxygen and Carbondioxide

In day time plant used CO2 for photosynthesis process and released O2.

In night time plant released CO2 and inhale O2 gas.

Excess amount of ion are deposit into dead cell of plant body such as bark.

The maintained the temperature of the body with in a range is called


Thermoregulation in Plant
The normal range of temperature in plant is 10oC to 35oC. The adaption of plant to
low and high temperature are as follows.

Low Temperature:

At low temperature the nature of plasma membrane is changed and produce

crystalline structure due to which transport of solute is slow.

To control this condition plant cell produce unsaturated.

At freezing point ice crystal are formed in the cell. But the plant of cold
region change the composition of solute of cell so ice crystal are not formed in
cytoplasm they form in cell wall. This condition is known as freezing

High Temperature:
High temperature has more harmful than low temperature for plant.
Due to high temperature all enzyme are denature and metabolic process stop.
So plant increase rate of transpiration and cool the body.

At above 40oC plant produce heat shock protein. They protect the enzyme
from destroying.

In some plant shiny cuticle is present which protest them from high

In some plant leaves are reduce in size.

Osmoregulation In Animal:
Osmoregulation in Terrestial Animal
In land animals excretion of water take place through body surface so they have
develop number of strategies to maintain Osmoregulation.

Water Proof External Covering Epidemics

Water proof external covering epidemics present in reptile, mammal cuticle present
in insect which prevent the water loss from their body.

Storage and Excretion of Solid Wastes

In birds, reptile and insect store nitrogenous waste uric acid. Uric acid insoluble in
water and help to reabsorption of water in cloeca. Uric acid excreted the body in the
form of paste and crystal.

Use of Metabolic Water

Some mammal fat is converted into simple compound and during this process water
is produce which is reused in the body. Camel, Kangroo used metabolic water.
Storage of Harmful Waste In mammal urea in kidney which is helps in reabsorption
of water.

Osmoregulation in Aquatic Animal

Osmoregulation in fresh water animal is maintained by two methods.
1. By Contractile Vacuole
2. By producing dilute urine

1. By Contractile Vacuole:
Fresh water unicellular organism have contractile vacuoles. Water with dissolved
CO2 and uric acid is collected from the endoplasm into the contractile vacuole,
which increase in size up to a maximum and burst released the extra substance in
environment. In Amoeba and Paramicium the amount of water and other substance
remain in balanced by contractile vacuole.

2. By Producing Dilute Urine:

Fresh water fishes have hypertonic body fluid as compare to surrounding water.
Fisher released extra amount of water in the form of dilute urine and absorb some
essential ion from outside to maintain the salt and water content in the body.

Osmoregulation in Marine Animal:

Marine water fishes have hypotonic body fluid than surrounding because sea water
have high concentration of salt so these fishes drink water continuously and the salt
excreted out along with concentrated urine. They also excrete salt through gills.

Excretion in Animal:
In animal removal of nitrogenous waste from the body is very essential. Animal have
particular organ to excrete out nitrogenous waste.
Waste Substance of Animal

Animal produce different type of waste substance such as

1. Ammonia
2. Urea
3. Uric Acid
4. Creatinine
5. Hypozenthine

1. Ammonia:

It is a small molecule of gas. Its formula is NH3.

It is highly soluble in water.

It is very toxic compound

It is dissolved in water and removes by simple diffusion method through skin

or by urine.

It is excretory substance of aquatic animal e.g. fishes.

2. Urea:

Urea is less soluble in water.

Its formula is CO(NH2).

Urea is very less toxic substance because its 1,00,000 time less toxic then

Urea is produce as a result of metabolism in the liver from ammonia.

NH3 + CO2 ------> Citruline ------> Aginine ------> Urea

This process required energy.

Urea is the excretory product of mostly land animal like mammals.

3. Uric Acid:

Its formula is C5O3N4H4.

It is not soluble in water.

Uric Acid is less toxic than urea.

Uric Acid released from the body in paste like substance or urete crystal.

Urid Acid is the excretory product of insect, birds and reptile.

Excretion in Hydra:
(Exetory Substance [NH3] )
Hydra is a water living animal. In this body the excretory products are produced in
the form of NH3. It is excreted out the gastrovascular cavity and then removed from
the body along with water.

Excretion in Planaria:
(Exetory Organs)
In planaria nitrogenous waste excrete out through skin and special excretory organ
called flame call or protonephridia.

Structure of Excretory System and Functions:

In the body of planaria there is a system of branch tube like bodies. There are two
longitudinal excretory trunks one on either side of the body.

They open to the out side by small pore called nephredipores.
Flame Cell
Internally these excretory trunk divide and redivide into number of small branches
at the end of the branch special cell are present are called flame cell. The flame cells
are club-shaped hollow cells. In their internal cavity many cilia are attached which
perform movement just like flame of candle.

All the waste product of main branches absorb by flame cell because the movement
of cilia of flame cell. When the excretory product come into the longitudinal
excretory system they are removed out of the body through the nephrediopore.

Excretory Organs:
The excretory system of earthworm consist of small, coiled tubes called
Metanephredia. It is present in each segment.

Structure of Nephredium:

Each Nephredium consist of three part.

1. Nephrostome
It is a rounded, ciliated funnel with the opening.

2. Bladder
Main body of nephridum consist of coiled tubular part and wide part called bladder.

3. Nephridiopore
The bladder opens outside by a small pore on the skin are called nephridiopore.

Excretion :
As fluid moves along the tubule, epithelium reabsorbs the salt from lumen and send
to blood vessels surrounding the nephridium. The left over appears as urine
containing nitrogenous waste.

Excretion in Cockroach:
Excretory Organs:
Cockroach have special tube like excretory structure are called "Malphighian
Tubules". It is present between the mid gut and hind gut. It is embedded in the

Excretion In Cockroach:
Malphighian tubules absorb all nitrogenous waste from blood and pour them into
illium. The latter part of tubules reabsorbs important substance. The uric acid when
come into rectum, it also reabsorbs water and salt, so uric became almost dry then it
is excreted out of the body.

Liver is the large raddish brown glandular organ which is central station of
metabolism and consequently the body is central metabolism clearing house.

Liver located in the abdomen just below the diaphragm.

Functions of Liver:
Liver is the main homeostatis organ which perform several function.

1. Metabolism of CHO and LIPIDS

Liver is the center of metabolism. Is take part in metabolism of carbohydrate

and lipid. It regulates the amount of glucose into the blood. Excess glucose is
converted into glycogen, which is reserve food. It amount of glucose is
decrease in the blood glycogen is broken into glucose. Glycogen is reduce
than liver convert amino acid into glucose.

Liver also help in oxidation of lipid. It is converted blood lipid into simple fat
which is stored in the body.

2. Deamination and Urea Formation

Excess of protein can not be store in body. Protein are change into amino acid.
Amine group is removed from the amino acid this process is called deamination of
form NH3. Amonia combine with CO2 and convert into urea by a cycle called
ornithine cycle.

3. Production of Bile
Liver produce a secretion called Bile. It is yellowish green alkaline substance. Bile
contain bile pigment biliverdin, bilirubin, salt such as sodium-glycocholate, Nataurocholate, Cholesterol, Phospholipid and mucous.
Functions of Bile
Bile neutralizes the acidic food

It kills the germs

It takes part in the emulsification of fat.

4. Detoxification
Liver convert toxic substance into non toxic substance this process are called
For example a compound hydrogen peroxide H2O2 is a harmful compound.
The liver secrete on enzyme catalase which convert H2O2 into H2 and O2
and became non poisonous substance.

5. Formation of Cholesterol
Liver also forms cholesterol which is necessary for the body. Its extra amount
is always excreted along with water.

6. Thermoregulation
Liver helps in regulation of body temperature by continue supply of blood
and metabolic process.

7. Storage of Vitamins
Liver stores vitamins such as A1B and D.

Biology XII (Notes)

Arranged By: Faisal Ahmed Jokhio

Urinary System in Human Being

Urinary system of man consist of
Kidneys are pair of dark red bean shaped structures which are attached to the dorsal
wall of the abdominal cavity.
Kidney are covered by a membrane are called peritoneum.

Urine leaves the kidney through a pair of duct called Ureter.

The ureters of both kidney drain into pear shaped thin walled structure are called

Urine leaves the body during urination from the bladder through a tube called

Sphincter muscles near the junction of the urethra and bladder control the urine in

Kidney are a pair of dark red bean shaped structures which are attached to the dorsal
wall of the abdominal cavity.

Structure of Kidney
Internally kidney consist of two part
1. Cortex is the outer and darker region.
2. Medulla is the inner and lighter region in the kidney. It contain many cone like
structure are called pyramids.

The basic structural and functional unit of kidney are called Nephron.
Kidney consist of million of microtubules are called Nephron.

Structure of Nephron
Each nephron is sub-divided into
1. Renal Corpuscle
2. Renal Tubule

1. Renal Corpuscle
Each renal corpuscle is divides into two
i. Bowman's Capsule
ii. Glomerulus

i. Bowman's Capsule:
In each nephron inner end forms a cup-shaped swelling called Bowman's
ii. Glomerulus:
Each bowman's capsule have a ball of capillaries called glomerulus. Glumerulus
circulates blood through capsule as it arrives through Aferent Arteriole. Blood
carried away from the capsule by a small vessel called Efferent Arteriole. The blood
vessel sub divide again into another network of capillaries called Peritubular

2. Renal Tubule
Bowman capsule continuous as extensively tubular system.
i. Proximal Convoluted tubule
ii. Loop of Henle
iii. Distal convoluted tubule
iv. Common collecting duct

i. Proximal Convoluted Tubule

Bowman capsule gives out a coiled tubule called Proximal Convoluted Tubule.

ii. Loop of Henle

The proximal convoluted opens into a U-Shaped structure called loop of Henle.
Loop of Henle consist of descending and ascending limbs.

iii. Distal Convoluted Tubule

The ascending limb of loop of Henle opens into another convoluted tubule called
Distal Convoluted Tubule.
iv. Collecting Tubules
Distal tubule empties into collecting tubules which open into pelvis.

Functions of Kidney:
Urine formation take place in these following steps:
1. Ultra Filtration
2. Selective Reabsorption
3. Tubular Secretion
4. Counter Current Exchange

2. Selective Reabsorption
All the important constituent of the glomerular filtrate are reabsorbed when filtrate
pass in tubular system.
Prominal convoluted tubule reabsorb salt amino acid, glucose and water.

Descending limb of loop of Henle reabsorb Na and Cl inter in the interstial

fluid. Na and Cl reabsorbed by active transport. Water is not reabsorb.

Distal convoluted tubule have hypotonic solution due to high concentration

of water. In this part by the action of hormones concentration of various salt
is adjust.

3. Tubular Secretion
Tubular section is also very important process of excretion. The tubular epithelium
also secrete substances into teh lumen this secretion is very selective and mainly of
hydrogen into balance pH value of the filtrate passing through the tubule.

5. Counter Current Exchange

The exchange of solute and water in the medulla of kidney is called counter
current exchange. There are two counter exchanges:
i. Counter Current Multiplier
ii. Counter Current of Vasa Recta

i. Counter Current Multiplier

When the filtrate passes through the descending limb of loop of Henle water is
reabsorbe due to this process the filtrate became hypertonic.

ii. Counter Current of Vasa Recta

The blood vessels which run parallel to the loop of Henle are called Vasa recta.
Through these blood vessels only about 10% of blood of kidney passes very
slowly. This blood supplies oxygen and nourishment to the cell of medulla and
carries away the reabsorb water from the filtrate. The system is regulate and
maintained properly.

Reabsorbtion in the Nephron:

Types of Nephron
There are two type of nephron
1. Cortical Nephron
2. Juxtamedullary Nephron

1. Cortical Nephron:
The nephron which have small length of loop of Henle and only present in cortex
region of kidney are called Cortical Nephron.

2. Juxtamedullary Nephron:
These nephron have long loop medullar of kidney reabsorb more water are
called juxtamedullary nephron.

Effect of Hormones on the Working of kidney

Certain hormones control the working of kidney.
1. Andiurelic Hormones (ADH)
2. Aldosteron Hormones (AH)
3. Parathormon Hormone (PTH)

1. Antidiurelic Hormones
Pituitary gland secrete ADH. It is also called vasopressin.

Hormones helps in reabsorption of water. Hormone is produce at the time of
dehydration. It causes shortage of water in the body due to rapid loss of water.
The osmotic pressure of blob increases. This hormone helps to balance the
amount of water.

2. Aldosteron Hormones
Outer part of adrenal cortex secreted aldosteron harmine.

It control the concentration of Na+ in the bosy fluid. It increase the reabsorption
of sodium ion in nephrone.

3. Parathormon Hormones
Parathyroid gland secrete parathormone.

Kidney Problems:
Kidney is not perform properly due to different reason are called Kidney
problem or Kidney disease.
There are many problems of kidney
1. Kidney Stone
2. Renal Failure

1. Kidney Stone:
Stone solid materials are found in the kidney called Kidney Stone.

Causes Of Kidney Stone:

Kidney stones are caused by metabolic disease.
70% of kidney stone are formed due to calcium oxalate and phosphate oxalate.
Oxalate are produced in the metabolic process and added in the urine and
deposit in kidney change into stones. Oxalates are present in green vegetables
and tomatoes therefore may be the source of oxalate stone.
Infective Stone

20% stone are called as infective stone. Infective stone consist of combination of
calcium, magnesium and ammonium phosphate.
Uric Acid Stone
5% stone are formed in uric acid.

The lithotripsy is used for non surgical removal of kidney stone. It is a technique
used to break up stones that form in the kidney, ureter or gall bladder.

Method Of Lithotripsy:
There are several way to do it although the most common is shock wave
lithotripsy or ultrasonic lithotripsy. High concentration X-Ray or ultrasound are
directed from a machine outside the body to the stone inside. The shock waves
break the stone in tiny pieces or into sand which are passed out of the body in

2.Renal Failure
Sometimes the working of kidney is badly damaged due to certain reason or
infection. They are not able to filter the harmful nitrogenous substance it is
called renal failure. In such condition the harmful substance remain in blood.


Loss of appetite


Difficulty in breathing

In severe condition patient may suffer by pneumonia, high blood pressure, coma
and ultimately death.

Treatment of Kidney Failure

A technique to remove nitrogenous wastes particularly the urea from the blood of
the patient is called Dialysis.
Type of Dialysis
There are two types of dialysis
1. Haemodialysis

2. Peritoneal Dialysis

1. Haemodialysis
Haemodialysis means "Cleaning the blood". In this procedure blood is circulated
through a machine which contains a dialyzer also called on artificial kidney.
Dialyzer has two spaces separated by thin membrance and dialysis fluid on the
other. The waste and excess water pass from the blood through the membrane into
the dialysis fluid. Dialysis take place 6 to 10 hours and 3 time in a week.

2. Peritoneal Dialysis
Abdomen has a peritoneal, lined by a thin epithelium called peritoneum. Peritoneal
cavity is filled with dialysis fluid that enters the body through a catheter. Excess
water and wastes pass through the peritoneum into the dialysis fluid. This process is
repeated several times in a day.

Kidney Transplant:
Dialysis may be used as temporary measure. In high degree renal failure also called
as Uremia or end stage renal disease, the dialysis is done endlessly thus the surgical
transplantation of matching donor kidney is only the option left as the permanent

Thermoregulation in Animal:
Temperature Classification of Animal
According to the body temperature animals are divides into two group.
1. Poikilotherms (Cold Blooded)
2. Homeotherms (Warm Blooded)

1. Poikilotherms (Cold Blooded):

Animal cannot maintain their body temperature and it can be changed according to
the climate are called Poikilotherms.
Amphibians, Reptile, Fishes.
2. Homeotherms:
Animal can maintain their body temperature. It does not changed according to their
environment are called Homeotherm.
Birds, Mammals
Many poikilotherm can maintain their body temperature and homeotherm do not

maintain their body temperature always. So there terms are changed.

Modern Classification of Animal:

The modern classification of animal according to the body temperature.
1. Ectothermic
2. Endothermic
3. Heterothermic

1. Ectothermic:
Ecto mean outside thermic mean heat so those animal obtained heat energy from
their environment are called Ecotothermic.
Invertibrate, Fish, Amphibian and Reptile.

2. Endothermic:
Endo mean inside thermic mean heat so those animals use internal energy which is
produced during their metabolism.
Mammalia, Birds and Some Fishes.
3. Heterothermic:
Those animals are able to maintain their body temperature with certain variation, so
their body temperature can be changed upto certain limits are called Heterothermic.
Bat, Humming birds.

Method of Thermoregulation in Animals

In animal thermoregulation occurs by two ways.
1. Behavioral Regulation
2. Physiological Regulation

1. Behavioral Regulation:
When temperature is maintained by the activity of animal body, it is called behavior
regulation, such as animals change their position to increase or decrease the

2. Physiological Regulation:
When temperature of the body is maintained by inter-physiological process it is

called physiological regulation, such as change in blood circulation etc.

Thermoregulation in Cold Temperature

In cold temperature animal regulate their body temperature by two methods.
1. Physiological Process
2. Behavioral Process

1. Physiological Regulation
This is the internal process of the body to maintain body temperature. It take place
by two way
i. Non-shivering thermogenesis
ii. Shivering thermogenesis

i. Non-Shivering Thermogenesis:
Hormones trigger the heat production as do thyroid hormones are called Nonshivering thermogenesis.
In this mechanism heat is produce by three methods.
Erection of hairs

Reduction of blood flow toward skin

Sub cutaneous fat accumulation

Erection of Hairs:
In cold season the hair become in erect position. In furry animals air is trapped
between the space of hairs and loss of body heat is stopped.
Reduction in Blood Flow toward Skin
In cold season the blood vessels of skin are reduced. It is called Vasoconstriction.
Due to this process blood flow towards skin become slow and loss of heat through
skin is reduced.
Sub Cutaneous Fat Accumulation
In mammals below skin fat is deposited in adipose cell. It prevent the loss of body
heat. It is common in aquatic animals such as Seal, Whale.

ii. Shivering Thermogenesis:

The rate of heat production is increased y increased muscle contraction by movement
or shivering so called as shivering thermogenesis.
In very cold weather shivering occur in the muscles of the body. It produce heat
Rate of Metabolism become faster. In this mechanism hormones are involved one

hormone adrenaline is produce by adrenal gland. It increases the supply of glucose

in blood so respiration become fast and energy is produce.
Thyroid gland also secreted thyroxin hormone in blood. This hormone also
increased respiration to produce heat.

2. Behavioral Process
In this mechanism the animals produce heat by their body activities.
Movement toward Hot Place
Animals move toward hot places during cold season.
Gathering of Animals
The animals come close to each other, so energy is produced.

Use of Warm Cloths:

Man used warm clothes for protection and to get heat.

Thermoregulation in Hot Temperature

In hot season the animal produce less heat and also released heat from their body. It
take place by two method.
1. Physiological Mechanism
2. Behavioral Mechanism

1. Physiological Mechanism:
This process take place by following method.
Less Fats Deposition:
In hot season fat is not deposit in below the skin. It loss the body heat.
Increase in Blood Flow toward Skin:
In hot season the blood vessels of skin are dilated and vasodialation occur to
released body heat.
Softness of Hair:
Hair of skin not erect in hot season not prevent the loss of heat energy.
Sweet Gland:
Sweet glands become active and water is excreted out through skin. The blood
becomes cold and internal temperature is maintained. It is called physiological
temperature regulation.

2. Behavioral Mechanism:
In this mechanism the animal released heat by their body activities.
Movement toward Cold Places:
Animal move from hot to cold places. They remain in shade or moist place to reduce
their body heat.
Use of Thin Clothes:
Man use thin clothes during summer season.

Role of Brain in Thermoregulation

The body temperature regulation in human is based on complex homeostatic system
facilitated by feedback mechanism.

The Control Center :

The homeostatic thermostate is present in the hypothalamus, a brain part. It
respond to the changes in the temperature above and below 37oC.

Warm Temperature:
Incase of increase in temperature above 37oC certain warm temperature sensitive
thermoreceptors in skin, hypothalamus and other parts of nervous system send the
signals to the system that increase the blood flow to the skin and also cause sweat
gland activation and sweat is evaporated for the cooling.

Cold Temperature:
In cold temperature, the cold receptor send the impulse to hypothalamus to inhibit
heat loss mechanism and activate the heat conservation mechanism.

When the temperature of the body is increased beyond a set point it is called Fever
or Pyrexia.

Cause of Fever
The main cause of fever is the viral or bacterial infection. These germs in blood
vessels produce a chemical substance called pyrogen. It increases the body
temperature than normal.

Fever helps to kill the germs

It indicates any abnormal condition in the body or infection.

Biology XII (Notes)

Arranged By: Faisal Ahmed Jokhio

The process through which organisms produce young ones of their own kind to
maintain their species are called as Reproduction.

Types of Reproduction:
There are two types of reproduction.
1. Asexual Reproduction
2. Sexual Reproduction

1. Asexual Reproduction:

The type of reproduction in which fusion of gamets does not take place and requires
only a single parental organism and the offspring produced are exact copies of their
parents. This type of reproduction is called Asexual Reproduction.
Asexual Reproduction of Plants
There are two methods of asexual reproduction in plants.
1. Natural Method of Asexual Reproduction
2. Artificial Method of Asexual Reproduction
1. Natural Method of Asexual Reproduction:
In nature, plants reproduce asexually by following methods.
i. By Spores or Sporulation
ii. Vegetative Propagation
iii. Apomixis
i. By Spores or Sporulation:
During alternation of generation plant produce haploid cell by meiosis called
Spores. Each spore can develop into new organism without fertilization. The process
of formation of unicellular spores is called Sporulation.
Sporulation occurs in bacteria, protozoans, algae, fungi, mosses and fern as well as
ii. Vegetative Propagation:
The process which involves the separation of the part of the parent plant which then
develop into new plant is called as Vegetative Propagation.
When a new plant develops from tissue, organs of a plant or outgrowth of a plant.
This type of reproduction is called Vegetative Propagation.
In this process a plants part is separated which develops into new plant such as
stem, leaves roots or buds may take part in the formation of new plant.
Methods of Vegetative Propagation
There are various method of propagation of plant by vegetative reproduction for
improving crops, orchads and ornamental plants are as follows
i. By Cutting
ii. By Grafting
i. By Cutting:
In this method stem or branch is cut from the plant. At the cut end of the shoot a
mass of dividing undifferentiated cells called a callus forms and then adventitous
roots develop form the callus. If the shoot fragment includes a node, then
adventitous root forms without callus stage.
Sugar cane, sweet potato and rose can be propagated by cutting. In raspberry and

black berries root cutting are also used for artificial vegetative propagation.
ii. By Grafting:
This is a technique whereby a branch from a desired variety of plant is joined to
another plant with well established root system. The plant from which the branch is
taken is called Scion and the plant to which it is joined is called Stock. The two
plants involved are normally the different varieties of same species.
Orange, lime and mango can be propagated by grafting.

iii. Apomixis
The modified form of asexual reproduction in which seeds are formed without
fertilization is called Apomixis.
In apomixis, a diploid cell in the ovule gives rise to the embryo without any
fertilization and the ovules mature into the seeds.
In Dandelions and other plants seed formation take place without fertilization.

2. Artificial Method of Asexual Reproduction

In plant vegetative reproduction is performed by artificial method, which are as
i. Tissue Culture or Test Tube Cloning
ii. Protoplast Fusion Technique

i. Tissue Culture or Test Tube Cloning:

Tissue culture or cloning is a special technique which is used to produce varieties of
plants. By this technique, a group of genetically identical offspring produced by
asexual method called Clones.

In this method, pieces of tissues are cut from the parent plant or from a single
parenchymatous cell in a medium containing all the nutrients and hormones.
The culture cells divide and form an undifferentiated Callus.
The callus then produces root and shoot with fully differentiated cells.
The test tube plant can be transferred to soil where they continue their growth.
In plants tissue culture is also used in genetic engineering. To introduce new genes in
plant body pieces of tissue or cells are used. By this technique, we produced a new
variety of plant by introducing new DNA molecule.
By cloning many thousand plants are produced from one plant. This method is used
in Orchards and pinus trees to obtain wood.

Advantages of Tissue Culture:

The main advantages of tissue culture are as follows

i. Development of Strong Plant: By this technique plants of Agriculture and

horticulture are produced. These plants are strong than other plants produced by
ii. Development of Similar Plant: By this technique plants of similar character are
iii. Development of Defence System in Plant: These plants have developed defence
mechanism against any disease.
iv. Production of Useful Chemicals: By this technique, many useful chemicals are
obtained such as shikonin (a dye used in silk and in the treatment of injuries caused
by burning.

Disadvantages of Tissue Culture:

There are also some disadvantages of tissue culture where are as follows
i. Production of Sterile Plant: The plant produced by this technique may be
genetically sterile, do not reproduce by sexual method.
ii. Variation in Chromosome: This technique may cause change in the structure and
number of chromosome.
ii. Protoplast Fusion Technique:
Another technique known as protoplast fusion technique is developed to produce
new varieties of plants.

In this technique, outer cell wall is removed around the protoplast. After protoplast
of one or more cells are fused together, then their protoplast are for culture. These
protoplast produce a wall around them, then they are change into new plant.
Protoplast of either same or different species may used for this technique.
In potato and wild night shade plant this technique is used.

2. Sexual Reproduction
The type of reproduction in which fusion of gametes (sperm and ova) take place and
two parents (male and female) are involved is termed as Sexual Reproduction.

Sexual Reproduction in Plant:

In plants sexual reproduction takes place by three methods.
i. Isogamy
ii. Oogamy
iii. Heterogamy
i. Isogamy:
The simplest type of sexual reproduction in which two morphologically similar
gametes take part in fertilization to produced zygospore which then develop into
new plant is called Isogamy.

It is also known as conjugation which means marriages of equals.

This process occurs in algae and lower plants.
ii. Oogamy:
The type of sexual reproduction in which a flagellated motile sperm fertilizes with
non motile egg to produced a diploid zygote which then develop into new individual
is called Oogamy.
Some species of algae undergoes Oogamy.
iii. Heterogamy:
The type of sexual reproduction in which two different structure gamets fused i.e.
non flagellated large size female gamete fuses with small size flagellated male
gamete to produced zygote which then develop into new plant is called Heterogamy.
It is also known as anisogamy.
In higher plants such as bryophyte, heterogamy is present.

The process in which dormant or sleeping embryo awakes up renews its life and
develops into a seeding is called as Germination.
The breaking of dormancy of seed to produce seedling is called Germination.

Kinds of Germination
Seed can germinate into three ways i.e.
1. Epigeal Germination
2. Hypogeal Germination
3. Viviparous Germination

1. Epigeal Germination:
Epi => above, geo => earth
The kind of germination in which cotyledons came above the soil due to rapid
growth of hypocotyl is called Epigeal Germination.
Caster oil seed, tomato, cotton etc.

2. Hypogeal Germination:
Hypo => below, geo => earth
The kind of germination in which cotyledons remain under the soil due to rapid

growth of epicotyl is called Hypogeal Germination.

Maize-grain, Pea-gram etc.

3. Viviparous Germination:
The special of germination in which seed germinates within fruit is called
Viviparous Germination.
The fruit is still attached to parent plant. Redicle comes out of the fruit which
becomes swollen and heavy due to increasing weight the seedling gets detached and
falls vertically into the soft mud gets embeded and starts growing.
Rhizophora, coconut, date palm etc.

Seed may be defined as
A ripened ovule or a part of a plant body in which embryo lives in dormant
condition is called Seed.

Structure of Seed
Structure of seed can be divided into two parts
1. External Structure
2. Internal Structure

1. External Structure:
Externally seed consists of following parts
Seed Coat
The seed is covered from outside by a coat called Seed Coat.
The seed coat is formed by integuments. It is made up of two layers.
The outer thicker layer is called Testa.
The inner thin layer is called Tegmen.

Chromosomes as Carrier of Genes:

Genes are small bodies found in the chromosome.
Chromosome are considered as the carrier of genes.
The chromosomes can be separately identified visually but the genes are very small

units. And so far have not been seen even with the best microscope.
The chromosome and gene behave as hereditary units but the genes can not be
considered outside the chromosome.
At the time of meiosis, the separation of homologous chromosomes takes place
which result in the segregation of gene pairs.
In the genotype of every individual one member of each pair of genes is contributed
by one parent and the other by the other parent.

Chromosomal Theory of Heredity

The chromosomal theory of inheritance was first formulated by the American
Biologist "Walter Sutton" in 1902.

The main postulates of this theory are as under
1. Hereditary Materials:
Reproduction involves the initial union of only two cells, egg and sperm. If Mendel's
model is correct then these two gametes must make equal hereditary contributions.
Sperm, however contain little cytoplasm, therefore the hereditary material must
reside within the nuclei of the gametes.
2. Segregation of Chromosomes:
Chromosomes segregated during meiosis in a manner similar to that exhibited by
the elements of Mendel's model.
3. Number of Chromosome:
Gametes have one copy of each pair of homologous chromosomes, diploid
individuals have two copies.
4. Independent Assortment:
During meiosis each pair of homologous chromosomes orients on the metaphase
plate independent of any other pair.

The objection on chromosomal theory of hereditary is that when there is
independent assortment of chromosomes in meiosis, the number of factors (genes) is
more than the number of chromosomes. This is considered as a fatal objection about
Sutton's theory.

The material which transmits the parental characters into the coming generation is
called Hereditary Material.

Fredrick Griffith's Experiment

Fred Griffith in 1928 provided the evidence of hereditary material in bacteria.
Experimental Material:
He was working on strains of steptococcus pneumoniae, which occurs in two distinct
different forms.
Rough surfaced, non-capsulated bacteria, without the capability of producing
i.e. non-virulent
Smooth surfaced, capsulated bacteria, with the capability of producing pneumonia
i.e. virulent.

Steps of Experiment:
He observed that when the injected R-type bacteria in the mice, there was no ill
When he injected the S-type, they proved to be fatal.
He also observed, when he injected both the bacteria separately after killing them
by heating under high temperature, the mice did not develop the disease.
He also observed that, when the injected the living R-type with heat-killed S-type,
there was a high morality among the mice.

Fred Griffith concluded that the R-type bacteria gained genetic property of S-type
inactive bacteria when they kept together, so R-type bacteria converted into virulent
S-type by the activity of DNA. Hence by this experiment, it can be proved that DNA
is a genetic material.
A Very, Macleod and McCarty's Experiment

In 1944, after a decade of research, Oswald Avery, Maclyn McCarty and Colin
Macleod discovered that the transforming agent had to be DNA.

They performed various experiments and found out that the only substance, which
carried the transforming capability, was DNA because if the enzyme deoxyribanuclease was added to the bacteria, the transforming capability was lot.

Hershey and Chase's Experiment

In 1952, Hershey and chase performed experiment to proof that DNA is a hereditary

Experience at Material:
Hershey and chase labeled protein coat and DNA of Bacteriophage separately.
Protein coat labeled with radioactive sulphur and DNA with radioactive
phosphorus. These two viruses use to attack bacterial cells.

Steps Experiment:
Hershey and chase observed that if cultures of bacteriophage are labeled with
radioactive phosphorus [P32 labeling DNA] or with sulphur [S35 for labeling
protein coat].
bacteriophage is ruptured, the DNA is released and treated with deoxyribsonucleas,
the DNA breaks up into fragments in the solution.
The empty protein coats of the ruptured membrane appear as coats all the P32 or
S35 were made to inject bacteria and multiply by the help of special technique, all
the S35 labeled protein were removed.
The new phage formed contained only P32 indicating the presence of DNA molecule.

The conclusion appears similar to the transforming principle in bacteria, showing
that DNA is the genetic material in phage, transmitted from one generation to the

Watson and Crick's Model of DNA

James Watson and Francis crick, in 1953 proposed structure of the DNA molecule.

Structure of DNA:
Watson and Crick suggested a ladder like organization of DNA.
1. Double Helix:
Each molecule of DNA is made up of two polynucleotide chains which twisted
around each other and form a double helix.
2. Backbone of DNA
The uprights of the ladder are made up of sugar and phosphate parts of nucleotide
and the rungs are made up of a paired nitrogenous bases.
3. Pairing of Bases:
The pairs are always as follows
Adenine always pairs with thymine and cytosine with Guanine.
The two polynucleotide chains are complimentary to each other and held together
by hydrogen bonds.

Hydrogen Bonding:
There are two hydrogen bonds between Adenine and Thymine (A=T) and three
between Cytosine and Guanine (CG).

Both polynucleotide strands remain separated by 20 A distance.
The coiling of double helix is right handed and complete turn occurs after 34 A. In
each turn 10 nucleotide pairs are present, therefore the distance between two pairs
is about 3.4 A.

Genes - The Unit of Hereditary Information

Archibald Garrod discovered in 1902, that certain diseases were more prevalent
among some families and were inherited as a recessive Mendelian trait.

Alkaptonuria is a disease in which the urine contained a substance called
"Alkapton" now known as "Homogentisic acid" which was immediately oxidizes to
black when exposed to the air.

He suggested that this disease occurred due to absence of an enzyme, which could
break the "Alkapton" down to other products so it would not build up in the urine.

He proposed that the condition was "An inborn error of metabolism" which is
occurring due to changes in the hereditary information, which must have occurred
in one of the ancestors of the affected families.

He concluded that the inherited disorders might reflect enzyme deficiencies.

The total genomic constitution of an individual is known as Genome.
In a bacterial cell, a single circular chromosome along with plasmid is genome of
bacteria, while in a human being all twenty two pairs of autosome along with a pair
of sex-chromosomes constitute genome.

Replication of DNA
The mechanism in which DNA prepares its copies is called DNA replication.
When the formation of new DNA molecule takes place in the cells without any
change, it is known as Replication of DNA.

Semi Conservative Replication

The type of replication in which new daughter double helical duplex contain one
stand old and another newly synthesized is called Semi Conservative Replication.

The Meselson Stahl Experiment

Mathew meselson and Frank Stahl performed experiments to test the semiconservative method of DNA replication.

They grew bacteria in a medium containing Nitrogen-15 (N15), a heavy isotope of
the nitrogen.

The DNA after several generations became denser than normal because the entire
bacterial DNA now contained Nitrogen-15 (N15).
They then transferred the bacteria into a new medium containing lighter isotope
Nitrogen 14 (N14) and analyzed the cultures for changes in the DNA.
At first DNA, which the bacteria synthesized, was all heavy.
After one round the density of the DNA fell exactly to the value one half between the
all heavy isotope DNA and all light isotope DNA.

This showed that after one round of replication, each of the daughter DNA duplex
contained one strand of heavy isotope, after two rounds half contained none of the
heavy isotope strand to form light duplex and half contained one of the heavy strand
It was now confirmed that the semi conservative method of the replication of DNA
replication was true.

One Gene One Enzyme Hypothesis

George Beadle and Coworker Edward L. Tatum proved that the information coded
within the DNA of a chromosome, is used to specify particular enzymes.

Method of Study:
Beadle and Tatum created Mandelian mutation in the chromosomes of the fungus
called Neurospora by the use of the x-rays.
They studied the effect of the mutations caused by them and suggested "One Gene
One Enzyme Hypothesis".

Choice of Material:
They choose the bread mold, neurospora crassa as an experimental organism. It had
a short life cycle and was easily grown on a defined medium, containing known
substances, such as glucose and NaCl.
The nutrition of Neurospora could be studied by its ability to metabolize sugars and
other chemicals the scientist could add or delete from the mixture of the medium.

Production of Mutations:
They induced mutations in Neurospora spores by using x-rays.
The mutated spores were placed on complete growth media enriched with all
necessary metabolites, so keeping the strains alive because the strains were deficient
in producing certain compounds necessary for fungus growth due to damaged DNA

by earlier irradiation, hence called Mutants.

Identification of Mutant Strains:

To test the mutations, they grew the mutated strains on the animal media containing
sugar, ammonia, salt, a few vitamins and water.
A strain that had lost the ability to make a necessary metabolite, failed to grow on
such media.
Using this approach, they succeeded in identifying and isolating the different

Identification of Specific Mutations:

To determine the specific nature of each mutation, they added various chemicals to
minimize media, to make the strains grow.
Using this technique, they were able to pinpoint the biochemical problem and thus
the genetic deficiency of the mutants.
Many of the mutants were unable to synthesize a single amino acid or a specific
If a spore lacked the ability to synthesize a particular amino acid, such as Arginine,
it only grew if the Arginine was added in the growth medium. Such mutants were
called as arg mutants.
Chromosome mapping studies on the organism facilitated their work and they
mapped three areas clusters of mutant Arginine genes.
For each enzyme in the arginine biosynthetic pathway, they were able to isolate a
mutant strain with a defective form of that enzyme and mutation always proved to
be located at one of a few specific chromosomal sites, different for each enzyme.

They concluded that genes produced effects by specifying the structure of enzymes
and that each gene encodes the structure of a single enzyme. This was called "One
Gene One Enzyme Hypothesis".

The single stranded helical polynucleotide contain ribose sugar and uracil instead of
thymine is called RNA.

RNA is formed in the nucleus (in nucleolus 10%) as well as in the cytoplasm (90%).

Types of RNA
There are three types of RNA.
1. Ribosomal RNA (rRNA)
The class of RNA found in ribosome is called ribosomal RNA.
During polypeptide synthesis it provides the site on the ribosome where the
polypeptide is assembled.
2. Transfer RNA (tRNA)
A second class of RNA is called transfer RNA is much smaller. Human cell contains
more than 40 different kinds of tRNA molecules.
During polypeptide synthesis tRNA molecules transport the amino acid into the
ribosome for the synthesis of polypeptide chain.

Biology XII (Notes)

Arranged By: Faisal Ahmed Jokhio

Support and Movement

The ability of an living organism to produce response against any stimula are called
Irritability it is also called Sensitivity.

Living organism shown the responses towards stimuli are called Movement.

Support in Plant

Plants require proper strength and support it is necessary to maintain their shape,
increase in size and keep them straight and strong. The support maintains balance.
In plant body support is provided by two ways.
* Turgidity in soft parts of plants
* Mechanical tissues

Support Through Turgor Pressure:

The living cell of epidemics, cortex and pith take in water by osmosis. Thus an
Internal hydrostatic pressure called "Turgor Pressure", which keeps them rigid and
resistant to bending. If they loose turgidity stem wilts. The turgor pressure is
extremely important to maintain the turgidity in plants.

Support Through Supporting Tissue

In plants there are certain tissue called Mechanical tissues. These tissue provide
strength to the plant body.
1. Parenchyma
2. Collenchyma
3. Sclerenchyma

1. Parenchyma
* Parenchyma is a simple tissue. It is composed of thin walled spherical, oval or
elongated cells.
* They are with or without Intercellular spaces.
* They are living cell.

They are found in cortex, pith and epidemics, mesophyll region of leaves.


Their function is synthesis of food and storage of food. They may serve as a
supporting tissue in soft plant due to internal turgor pressure.

2. Collenchyma
* Collencym is a simple permanent tissue. It is composed of rounded, oval or
polygonal cells.
* They are living cells with protoplasm.
* Intra cellular spaces are absent and these cells thickened at the corners due to
deposition of cellulose and protopectin.

These tissues are found in the dicot stem below the epidermis.

Collenchyma cell provide support to young herbaceous part of the plant. It elongate
with the grow stem and leaves.

3. Sclerenchyma
* Sclerenchyma is a simple permanent tissue. It is composed of long, narrow thick
walled cell.
* They have no intracellular spaces.
* They are dead cell without protoplasm.
* A thick materials is deposit along the wall of cell called pectin and lignin.

Sclerenchyma tissues are found in xylem which are vascular tissue.

They provide strength and Mechanical support to the plant parts.

Types of Sclerenchyma
There are two type of sclerenchyma
1. Fibers
2. Sclerides

1. Fibers:
The sclerenchyma elongated cell with tapered ends. They are tough and strong but
flexible Fibers.

2. Sclerides
The variable often irregular in shape sclerenchyma are called sclereids. Simple
unbranched sclerids are generally called stone cell.

Secondary Growth
An increase in plant girth due to the activity of cambium ring is called secondary

Secondary Tissue:
Tissues which are formed by the activity of cambium ring are called secondary

Significance of Secondary Tissue

Cambium Ring:
The ring of activity dividing cells responsible for lateral growth in plant are called
cambium ring.
Secondary growth occurs due to cell division in cambium ring. There are two type

i. Vascular Cambium Ring:

The cambium present between xylem and phloem is called Vascular Cambium Ring.
The cell within the vascular bundles are called fusiform initials.

Vascular cambium gives rise to two new tissues.

* Secondary Xylem (Toward the inside)
* Secondary Phloem (Toward the outside)

Growth Rings:
The secondary Xylem causes most of the increase in stem thickness. Over the year a
woody stem get thicker and thicker as it vascular cambium produce layer upon
payer of secondary Xylem. These layers are visible as rings.

Sap Wood and Heart Wood:

The outer region of secondary wood is of lighter color and take part in the
conduction of water from root to leaf are called Sap Wood.
The inner region of secondary wood is dark brown in color and do not take part in
the conduction of water are called Heart Wood.
In most plant heart wood accumulate a variety of chemical such as resins, oil, gum
and tannins. Which provide a resistant to decay and insect attack.

ii. Cork Cambium Ring:

The cambium ring present in cortex region and increase the diameter of stem are
called cork cambium ring.
Cork cambium cell divide and form new cells on both side.
* Cork / Phellem ------> Outerside
* Secondary Cortex ------> Inner Side

Cork / Phellum:
Cork is formed on the outer side by the cork cambium. Which is an insulating layer
prevent transpiration. Cork cell are dead and thick wall.

Secondary Cortex:
It is formed on the inner side by cork cambium. It is consist of few layers of
parenchymatous cells. They contain chloroplast.


Epidemics, lenticels and cork collectively called bark which is the outer part of stem.

Another important function of the cambium is to form callus or wood tissue on over
the wound. The tissue are rapidly formed below the damage surface of stem and

Movement in Plant
Any action taken by living organs to reduce its irritability produce by stimuli are
called Movement.

Type of Movement
There are two type of movement in plant.
1. Autonomic Movement
2. Paratonic Movement

1. Autonomic Movement:
Movement which occurs due to internal stimuli factor inherent inside the plant body
itself are called Autonomic or spontaneous movement.
Types of Autonomic Movement
There are three type of autonomic movement.
i. Locomotory Movement
ii. Growth Curvature Movement
iii. Turgor Movement

i. Locomotory Movement
Movement of whole plant body or an organ or material within plant cell from one
place to another due to internal stimuli is called movement of locomotion.

* The streaming movement of cytoplasm (Cyclosis).
* Movement of chromosome during cell division.

ii. Growth Curvature Movement

Change in the form and shape of plants or plant organs due to the differences in the
ratio of growth of different parts are called growth and curvature movement.
Types of Growth Curvature
There are two type of growth movement.
* Nutation
* Nastic
The growth tip of young stem moves in zigzag manner due to alternate changes in
growth on opposite side of the apex. This type of growth is called nutation.
Movement of climber around any rope as found in railway crupper.
When the process of growth occurs in different manner in the parts of a plant and
slow in other part it is called Nastic Movement.
There are two type of Nastic movement
* Epinastic
* Hyponastic

When faster growth occurs on the upper side of the organ is known as epinastic.

When faster growth occurs on the lower side of the organ is known as hyponastic.

iii. Turgo Movement

Movement occur due to change in the turgidity and size of cells as a result of loose
or gain of water called Turgo Movement.
* Movement of leaves of touch me not.

2. Paratonic Movement:
The movement occurs due to external stimuli are called paratonic or Induce

Type of Paratonic Movement

There are two type of paratonic movement.
1. Nastic Movement
2. Tropic Movement

1. Nastic Movement:
The non directional movement of parts of plant in response to external stimuli are
called Nastic Movement.
Usually this movement occur in leaves or petals of flower.

Types of Nastic Movement

There are two types of nastic movement
i. Photonastic
ii. Haptonastic

i. Photonastic:
The nastic movement occurs due to light are called photonastic.
The flower open and close due to light intensity.

ii. Haptonastic:
The nastic movement occurs due to the touch of any living organism are called


2. Tropic Movement
Tropic ------> Tropos mean "to turn"
The movement in response of growth of whole organ toward and away from stimuli
are called tropic movement. It is also known as directional movement.

Types of Nastic Movement

The main types of tropic movement are as follow
* Phototropism
* Geotropism
* Chemotropism
* Hydrotropism
* Thigmotropism

Photo ------> Light Tropos ------> turn
The movement of part of plant in response to stimulus of light are called
* Positive phototropism in stem
* Negative phototropism in root

Geo ------> earth Tropos ------ turn
The movement of part of plant in response to force of gravity are called Geotropism.

Root display positive Geotropism and shoots negative geotropism.

Chemo ------> Chemical Tropos ------> turn
The movement in response to some chemicals is called Chemotropism.
The hyphase of fungi show chemotropism.

Hydro ------> Water Tropism ------> turn
The movement of plant parts in response to stimulus of water is called
The growth of root toward water is due to positive hydrotropism and shoots
negative hydrotropism.

Thigmos ------> touch Tropos ------> turn
The movement of plant parts in response to stimulus of touch are called
The movement in climber

The tough hard and rigid framework of the body which gives particular shape and
support to animal body are called Skeleton.

Human Skeleton:
Endoskeleton present inside the human body. It consist of 206 bones. In man

endoskeleton divide into two parts.

1. Axial Skeleton
2. Appendicular Skeleton

1. Axial Skeleton:
The skeleton composed of skull, sternum, ribs and vertebral column are called Axial

i. Skull
The skull is made up of cranium and facial bones.

The part of the skull consist of eight bones and form a box like structure which
protect the brain are called Cranium.

*Facial Bones:
The other bones of skull form face are called facial bones. There are 14 facial bones
such as check bones, upper jaws and lower jaws single bone called dentary.

ii. Ribs Cage

Ribs are semicircular bones attached on their dorsal side with the vertebrae and on
their ventral side with sternum.
Rib Cage is composed of 12 pairs of ribs. The lower two pairs of ribs are called
floating ribs because they do not attached with the sternum.

The rib cage enclosed the chest cavity and protects heart and lungs.

iii. Sternum
The narrow rod shaped bones present in ventral wall of thorax are called sternum.

It is also known as breast bone.

iv. Vertebral Column

A hollow spine in which spinal cord protected extend from skull to pelvis are called
V column.

*Bones of Vertebral Column:

The vertebral column consists of 33 bones called vertebrate but due to fusion 26
bones are formed.

2. Appendicular Skeleton:
The skeleton system consist of pectoral girdle and hind limbs and easy to move are
called Appendicular skeleton.

Pectoral Girdle and Fore Limb

*Pectoral Girdle:
The girdle present in shoulder region and attach the arm to the trunk are called
Pectoral Girdle.

Parts of Pectoral Girdle:

Pectoral girdle consist of two parts.
1. Scapula ------> board part
2. Clavicle ------> Collar bone which connects scapula with sternum.

For Limb consist of

* Humerus (1)
* Radius (1)
* Ulna (1)
* Carpals (8)
* Meta Carpals (5)
* Phalanges (14)

Arrangement of Bones in Fore Limb

Arm: Humerus forms ball and socker joint with scapular while at distal end
humerus forms hinge joint with radius and ulna.

Wrist: The radius and ulna at their distal end from multistage with eight wrist
bones called Carpals.

Hand: Five metacarpals from the frame work of palm of the hand.
Digits: Five rows of the phalonges in fingers are attached to the meta carpals. They
support the finger.

Pelvic Girdle and Hind Limb

Pelvic Girdle:
The girdle present in lower region (hip region) and attached the hind limbs (legs) to
the vertebral column are called Pelvic gridle.

Structure of Pelvic Girdle:

Each pelvic girdle consist of large bone called Innominate. It is formed by the fusion
of three bones called Illium, Ischium and Pubis.

Hind Limbs:
The hind limbs consist of
* Femur (1)
* Tibia (1)
* Fibula (1) + Patella (1)
* Tarsals (8)
* Meta tarsals (5)
* Phalanges (14)

Arrangement of Bones in Fore Limb

Thigh: Femur is the largest bones of the body which forms a ball and socket joint
with the Pelvic girdle.

Knee and Calf: At the distal end the femur from knee joint with the proximal end
of two parallel bones called tibia and fibula.

Ankle: The distal end of the tibia and fibula form a joint with eight tarsals, which
are also attached with five meta tarsal bones of foot.

Digits: Five rows of the fourteen phalonges of the toes are attached with meta

Biology XII (Notes)

Arranged By: Faisal Ahmed Jokhio

Types of Skeleton
There are three main types of skeleton in animals.
1. Hydrostatic Skeleton
2. Exoskeleton
3. Endo Skeleton

1. Hydrostatic Skeleton:
A fluid filled gastro vascular cavity or coelom act like a skeleton are called
hydrostatic skeleton.
Hydrostatic skeleton provides support and resistance to the contraction of muscle so

motility results.
Hydrostatic skeleton found in annelids and other soft bodies invertebrate.
Mechanism of Working:
The fluid filled body cavity of in these animals is surrounding by layer of two types
of muscles.
Circular Muscles

Longitudinal Muscles

When circular muscles contract and pressure comes on body fluid by this process
the body become elongated and hard.
When the longitudinal muscles contract the body becomes short and thick due to the
lengthen and shorten body move easily in the soil.

2. Exoskeleton:
The hard non living external covering that is secreted by the outer epidermal layer
of animals are called exoskeleton.
The skeleton present outside the body are called Exoskeleton.
Composition of Exoskeleton:
Exoskeleton are made up of different materials.
1. Silica:
The exoskeleton of single celled diatoms made up of silica.
2. Calcium Carbonate:
The exoskeleton of mollusks made up of lime (Caco3)
3. Cuticle:
The exoskeleton of arthropods made up of hard, non living substance called chitin.
It is the complex of protein and carbohydrates. This exoskeleton is dividing by soft
flexible joints.
It provides a surface to which internal muscle can be attached.

It provides the protection and support to the body.

It is not help in locomotion but in arthropod. It helps in movement due to


Disadvantages of Exoskeleton
1. Due to exoskeleton the size of arthropods is short.
2. Growth is also limited because the exoskeleton is non living and non growing.
3. Moulting or ecdysis: When the size of animal increase the exoskeleton become

short and it is separated from the body. It is replaced by a new skeleton this process
are called moulting.

3. Endoskeleton:
The skeleton present inside the body and made up of rigid living connecting tissue
bones and cartilages are called endoskeleton.

Functions of Skeleton:
1. Support and Shape:
It provides supporting frame work of the body, it gives the body a particular shape.
2. Protection:
Bones protect critical internal organs, such as brain spinal cord, heart, lungs and
reproductive organs.
3. Movement:
Skeletal muscles attached to the bones help move the body.
4. Mineral Homeostasis:
Bones serve as depository for calcium, phosphorus, sodium and potassium. Bones
can release or take up minerals through negative feed back mechanisms to maintain
the homeostasis.
5. Blood Cell Production:
Red and white blood cells are produced in bone narrow.

Bones and Cartilages

In vertebrate animals the endoskeleton contains two types of connective tissues.
1. Bones
2. Cartilage

1. Bones:
Bones is the most rigid form of connective tissue.
Structure of Bones:
Cell of bones are called Osteocytes. They secrete a gel like matrix around them. It
contains a network of collagen fibres but unlike cartilages it is hardened by the
deposition of Osteoblasts and crystals of calcium phosphate. This process called
Ossification or Calcification, takes place in the presence of vitamin D.

2. Cartilage
Cartilage is the softer and flexible form of connective tissue.
Structure of Cartilage:
The living cells of cartilage are called chondrocytes. These cells secrete flexible,
elastic, non-living matrix. It consists of protein and polysaccharides. The main
protein in the matrix is collagen whose fibres run in all directions and surrounds the

chondrocytes. No blood vessels penetrate into this cartilage.

It covers ends of the bone at the joint and also supports the flexible portion of nose,
external ears and larynx.

The point at which two or more bones connect each other are called Joint. The help
in motality of skeleton.

Types of Joint on the Basis of Movement

Joints are classified on the basis of the amount of movement allowed by them, into
three categories.
i. Immovable Joints
ii. Slightly Moveable Joints
iii. Freely Moveable
i. Immovable Joints:
The joints fit together tightly like the pieces to a puzzle. These joints are called
immoveable joints or fixed joints because they don't allow the joining bones to
Example of fixed joint are the joints of skull in the term of case to protect the brain.
ii. Partially Moveable Joints:
The joints which allow a little government is called partially moveable joints or
slightly moveable joints.
Example of partially moveable joint is the attachment of ribs with vertebrate. These
joints permit out ribs to moves ups and down while we breath.
iii. Freely Moveable Joints:
The joints which allow the movement in several directions is called freely moveable
Types of Freely Moveable Joint
Freely moveable joint that are present in human skeleton system are
i. Ball and Socket Joint
ii. Hing Joint
iii. Pivot Joint
iv. Sliding Joint
v. Gliding Joint
i. Ball and Socket Joint:
The joint which allow the movement in all directions even in a circle is called ball
and socket joint.
In this joint ball like head of the long bone of leg and upper are fit into a cup like

socket of girdle.
Joint of hibs and shoulder
ii. Hing Joint:
The joints that allow the movement in two directions such as show the back and
forth movement is called hing joint.
Joint of fingers, elbow and knee.
iii. Pivot Joint:
The joints which allow a twisting movement as well as side way movement is called
pivot joint.
Joints of elbow and skull connected to the spine are the examples of pivot joint.
iv. Sliding Joint:
The joints which allow the bones to slides over one another and show the movement
in many directions are called sliding joint.
Joints of wrist and ankle.
v. Gliding Joints:
The joints in which bones moves easily over one another in a back and forth manner
is called gliding joints.
Joints of vertebral column that makes the back bone flexible are the example of
gliding joint.

Structure of Hing and Ball and Socket Joint

At moveable joints the joining bones are held in place by strong straps of
connective tissues called Ligaments. Ligaments connect the bones to each
other and don't allow the bones to slip and dislocate at a joint. As ligaments
stretch they allow the joints to move.

Highly moveable joints also need lubrication and cushioning to prevent the
adjoining bones crushing with each other. This is the function of Synovial
Cavities prevent around fluid the reduces the friction and keeps the joint
moving freely.

In addition cartilage pads at the end of bones act as shock absorber and
present bones from grinding together.

Deformities Skeleton:

Human skeleton support and upright body. Sometimes in skeleton certain disorders
are developed which weak a skeleton system are termed as Deformities of skeleton.

Causes of Deformities:
The causes of deformities are
1. Genetic Disorder
2. Hormonal Disorder
3. Nutritional or Malnutrition
4. Physical Trauma

1. Genetic Disorder:
i. Cleft Palate:
It is a genetic disorder in which cleft present in the palate which interferes with
sucking. It can lead to inhalation of food into the lungs causing aspiration
ii. Microcephaly:
It is genetic disorder in which the skull becomes small sized.
iii. Arithritis:
Arthritis is the inflammatory or degenerative disease that damage the joints. Osteo
arthritis is the most chronic arthritis which is a degenerative joint disease also
caused by genetic defect.

2. Hormonal Disorder:
The skeleton deformities of the bones caused by hormonal deficiency.
i. Osteoporosis:
Osteoporosis mostly occurs in aged women, which is related to decrease the level of
estrogen hormone.
In osteoporosis, the bones become porous, thin and weak and consequently easily

3. Nutritional Or Malnutrition:
The skeleton deformities occur in the bones due to nutritional deficiency.
Some of the nutritional disorders are
i. Osteomalacia:
Osteomalacia is the softening of bones in which the bones receive in adequate
minerals and patient feels pain when weight is put on affected bones. In this disease
calcium salts are not deposited and hence bones soften and weaken weight bearing

bones of legs and pelvis, bend and deform.

ii. Rickets:
Rickets in children results in bowed legs and deformed pelvis. It is caused by
deficiency of calcium in diet or vitamin D deficiency. It treated by vitamin D
fortified milk and exposing sink to sunlight to cure disorder.

4. Physical Trauma:
Certain diseases caused by physical trauma are as follows
i. Disc slip
ii. Spondylosis
iii. Arthritis
iv. Sciatica

i. Disc Slip:
The backbone of body consists of many vertebrate. Between these vertebrate special
cartilage pad are present called Disc.
The discs act as shock absorber during walking, jumping, running and lesser extend
to the bend laterlly.
If due to physical trauma, the cartilaginous ring of disc ruptures and displaces it is
called Disc Slip.
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Protrution presses spinal nerve and cause sever pain.

Unability to move.

As a result of disc slip the person should use hard bed and should take rest
for long time.

Pain killer medicine should be used.

ii. Spondylosis:
Spondylosis is deformity of joints of two vertebrate particularly of neck region when
the space between two vertebrate becomes narrow.

Due to spondylosis the nerves of spinal cord are pressed. It causes pain in neck
shoulder and upper parts of arm.
In this condition a hard collar is used around neck.

Pain killer are used.

iii. Arthritis:
Arthritis is inflammatory or degeneration disease that damage joints.
It may be due to

Viral Infection


Old age

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It results in pain, stiffness, swelling of the joint.

Smooth and flexible cartilage between the bones of a joint is denatured by

the deposits of calcium, which makes the cartilages hard.

Knee joint and hip joint can be replaced by artificial rubber or plastic joint.

Sometimes it is treated by medicines and physiotherapy.

iv. Sciatica:
Sciatica is a nerve pain of hind limbs which occur when nerve of sciatic plexus is
being pressed.
It may be due to

Disc Slip

Improper administration of injection in the iliac vein.

It makes the leg highly painful and virtually immovable.
The treatment of sciatica is very slow and prolonged. There is no permanent
treatment of this disorder.

Muscular System
Muscle made up to muscular tissue. A muscular tissue is a group of specialized cells
contain numerous filament of protein and perform a unique functions to generates a
pulling force.
There are more than 600 muscles in a human body and almost half of body weight is
due muscles.

Types of Muscles:
The vertebrate possess three kinds of muscles
1. Skeleton Muscles
2. Smooth Muscles
3. Cardiac Muscles

1. Skeleton Muscles:
The muscles that are attached with the skeleton and associated with the movement
of bones are called Skeleton Muscles.
Skeleton muscles are voluntary in function.

They can contract strongly and rapidly but fatigue quickly.

Skeleton muscle are striated muscles because they show alternate dark and
light band.

They are under the control of somatic nervous system.

Muscles are attached to the bones by special structure called tendon.

With the help of skeleton muscles all the body parts can move.

2. Smooth Muscles:
The simplest type of muscles which form all the internal hollow body's organs and it
found in throughout animal kingdom, called smooth muscles.
Smooth muscles are structurally very simple muscles. They are spindle shapes uninucleated cells. They are arranged in a sheet around the hollow organs of the body.
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These are unstriated muscles.

They are involuntary in function i.e. their movement is not in our control but
they are controlled by hormones and autonomic nervous system.

They contract more slowly than skeleton muscles but it can prolonged for a
long period of time.

These muscles are found in the blood vessels, digestive tract and many other organs.
Smooth muscles push the food to the digestive track.

They empty the urinary bladder.

They control the diameter of the blood vessels.

They also control the diameter of the pupit of eye.

3. Cardiac Muscles:
The muscles which are present only inside the wall of heart are called Cardiac
These are striated muscles.

They are involuntary in function and fatigueless.

They contract and relax continuously in a rhythmic pattern. This rhythmic

contraction called heart beat.

Cardiac muscles have more mitochondria to continuous supply of energy to

the tissues of heart.

Cardiac muscles regulate by the sino atrial node (SAN) or pace maker.

*Heart is quite independent of nervous system for its contraction and heart beat is
generated by the cardiac muscles itself.
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They are uninucleated or binucleated and branched to create a meshwork of
contractile tissue hence their fibres can not be separated like that of a skeletal
The function of cardiac muscle is pump the blood.

M.Faisal Jokhio Contact # 03142027382

Structure of Skeleton Muscles

Muscle Fibre:
Each skeleton muscle is actually a bundle of long and parallel closely packed thread
like multinucleated cells called the muscle fibres.

Skeleton muscle fibres are huge cells. Their diameters is 10 to 100 mm.

Structure of Muscle Fibre:

Each muscle fibre is bounded by thin elastic membrane called Sarcolemma. Similar
to plasma membrane. Inside the sarcolemma, there is a semifluid called Sarcoplasm.

Each muscle fibre contain a large number of many individual, ultra microscopic
contractile fine thread like structure called Myofibril.
The diameter of myofibril is 1-2 mm that run in parallel fashion and extend entire

length of the cell.

The myofibrils consist of smaller contractile units called Sarcomere.

Structure of Sarcomere:
In each sarcomere a series of dark and light band are evident along the length of
each myofibril.

The myofibril contains myofilaments or mocrofilaments. Microfilament is made up
of two types of filament.
i. Thick Filament
ii. Thin Filament

i. Thick Filament:
The central thick filaments extend the entire length of the A-band. The thick
filament which is about 16mm in diameter is composed of myosin.

Structure of Myosin:
Each myosin molecule has tail terminating in two globular heads. Myosin tail
consists of two long polypeptide chain coiled together. The heads are sometimes
called cross bridge because they link the thick and thin myofilaments together
during contraction.

ii. Thin Filament:

The thin filaments extend across. The I-band and pathway into A-band. Thin
filaments are 7-8 mm thick and composed of chiefly actin molecule.

Structure of Actin:
The actin molecules are arranged in two chains which twist around each other like
twisted double strand of pcarls. Twisting around the actin chains are two strands of
another protein tropomyosin. The other major protein in thin filament is troponin.
It is actually three polypeptide complex. One bind to actin, another binds to
tropomyosin while third binds calcium ions.

The area which appear light and contain only thin filament is called I-Band.

The area which appear bright and contain only thick filament is called H-Band.

The area of sarcomere which appear dark and contain both thick and thin filament
is called A-Band

Mechanism of Contraction of Skeleton Muscles

There are two theories which explain the mechanism of contraction of skeleton
1. Sliding Filament Theory
2. Cross Bridge Theory

1. Sliding Filament Theory

H.Huxley and A.F. Huxley and their colleagues suggested a hypothesis in 1954 to
explain all even in muscle contraction this is called Sliding Filament Theory.
According to this theory
The thin and thick filament of a muscle fibre move together by sliding over each
other. This is like sliding the fingers of our hand between fingers of the other hand.
The sliding of the filaments is the reason that the muscle gets shorter and thicker.

2. Cross Bridge Theory

When the bulbous heads end of the myosin filament discovered so the another
theory explain the mechanism of contraction of muscle which show physical contact
are called Cross Bridge Theory.
According to this theory
The bulbarious head of thick filament myosin become attached to binding sites on
the actin filament. The cross bridge are formed then contract to pull the actin
filament towards center of sarcomere and the muscles become contract.
Motor Unit:
A set of all the muscle fibres innervated by the branched of the single neuron and a
single muscle fibre is made up of many motors units.

Controls of Muscle Contraction

The contraction of a muscle depends upon three factors.
1. Nerve Impulse

2. Energy
3. Calcium Ions

1. Nerve Impulses:
Nerve impulse cause muscle contraction. The nerve impulses (nerve message) are
recieved from brain and spinal cord through motor nerves. The muscles entirely
depend upon these nerve impulses. When these impulses do not reach to the
muscles, they become fatigue. They loss stimulation and contraction stops gradually.

2. Energy:
Muscles also need energy for contraction. Energy required for muscle contraction
comes from food. The energy from food is stored in muscles in the form of glycogen.
It is transformed from glycogen to creative phosphate and finally to ATP where it is
stored and is readily available for use of muscle.

3. Calcium Ions:
Calcium ions play very important role in the initiation of muscle fibre contraction.
It is stored in sarcoplasmic reticulum.
When the nerve impulse reaches the acetyl choline is released.

Due to acetyl choline great number of calcium ions released from

Sarcoplasmic reticulum.

The calcium ions bind to troponin molecule and exposed the active site of
actin molecule.

The cross bridge is formed between actin and myosin and the muscles
become contracted.

After contraction has occurred the impulse stops, calcium ions back into
sarcoplasmic reticulum and the muscles fibres relaxed again.

Muscle fatigue is a state of physiological unability to contract.
When the muscles become functionless it is called Fatigue.

ATP Deficit:
Muscle fatigue results from relative deficit of ATP, not its total absence.

Lactic Acid Accumulation:

Excess accumulation of lactic acid due to the breakdown of glucose in absence of O2
and ionic imbalances also causes muscle pH to drop and the muscle to ache hence
causes extreme fatigue.

When the heavy exercise stops and continues the supply the excess oxygen to the
fatigued tissues, which now break lactic acid into water and carbon dioxide. Lactic
acid is converted the fatigued condition of the muscle is over. The amount of oxygen
needed to remove lactic from the tired muscle is called Oxygen Dept.

Abnormal Muscle Contraction

There are two common abnormal muscle contractions
1. Tetany
2. Cramps

1. Tetany:
Tetany is a sudden involuntary contraction of striated muscle.

Tetany is caused by the low level of calcium in the blood.

It excites neurons which influence the muscles contract before gaining the normal
position of actin and myosin filaments, therefore it is called abnormal function. In
tetany there is continue contraction of muscle fibres. Due to this continue
contraction the Ca++ ions cannot be separated from the sarcoplasm of muscles and
continue contraction becomes very rapid, so it is known as Tetany. If tetany occurs
in respiratory organs, they may become functionless.

2. Cramps:
It is also known as titanic contraction of entire muscle. It lasts for just few seconds
or several hours, causing the muscles to become taut and painful. It is most common
in thigh and hip muscles, it usually occurs at night or after exercise.

The main causes for cramps are as follows
Sugar level in blood is reduced

Sometimes dehydration occurs in the body.

Electrolytes (ions) are not in balance state.

Extra exercise is also harmful and causes cramps.

Simultaneous squeezing and stretching the cramped muscle may help.

Antagonisitic Muscles:
The muscles work in pairs with one muscle working against the other are called
Antagonisitic Muscles.

Types of Antagonisitic Muscles:

On the basis of their function and affect they produce the muscles are of following
1. Protractor and Retractor
Protractor Muscle: These muscle pull the lower part of limb in forward direction.
Retractor Muscle: These muscle pull the limb in backward direction.

2. Abductor and Adductor:

Abductor Muscle: These muscle pull the limb away from the body.
Adductor Muscle: These muscle pull the limb towards the body.

3. Flexor and Extensor:

Flexor Muscle: They close the joint.
Extensor Muscle: These muscle open the joint.

Locomation in Protozoa
Protozoans are the unicellular animals. Then locomotion is carried out by single
called structures. These are of three types Pseudopodia, cilia and flagella. These
structures arise from the body surface and may also help to capture the food.

1. Locomotion in Amoeba
Organs of Locomotion:
Locomotion in Amoeba is called amoeboid movement. Amoeboid movement takes
place by means of Pseudopodia.
Method of Locomotion:
The pseudopodia are finger like projections in the direction of movement. After the
formation of pseudopodia the Amoeba attaches with the substratum and pull the
body in the forward direction.
The exact mechanism of pseudopodia formation is still not known.

2. Locomotion in Euglena
Organs of Locomotion:
Euglena moves with the help of flagellum.
Methods of Locomotion:
As the flagellum is whipped backward the organism moves forward. However, when
flagellum moves forward the Euglena does not move backward. Flagellum is at is
anterior end of the body and pulls the organism forward. Wave of activity generated
by itself and they pass in spiral fashion from its base in spiral fashion from its base
to its tip.
Euglena increases amplitude and velocity. The activity of the flagellum caused the
body of Euglena to rotate forward abouts its axis.
Euglenoid Movement:
In this mode of locomotion, a wave of contraction and expansion passes from the
anterior to posterior in entire body. The contraction and expansion is brought by the
contraction of protoplasm. The body becomes shorter and wider first at the anterior,
then in the middle and finally at posterior.

3. Locomotion in Paramecium
Organs of Locomotion:
Paramecium moves with the help of Cilia. The movement by cilia is called Ciliary
Structure of Cilia:
Cilia are short fine thread-like extensions of the cell membrane.
Method of Locomotion:
The locomotion in paramecium take place by the beating of these cilia. The beating
action occurs in two strokes.
Effective Strokes:
During effective stroke the cilia become rigid and bent backward but obliquely
propel the animal forward.
Recovery Strokes:
During recovery stroke the cilia become softer and returns to it original position.
As a result of effective and recovery stroke paramecium swims against water. The
body move forwards.

4. Locomotion in Animals

1. Locomotion in Jelly Fish:

Jelly fish has umbrella like body which floats on the surface of water at the mercy of
waves. However it can swim slowly by muscular contraction.
In jelly fish the water enters in the umbrella like body (Bell). Then the muscle of the
body contract and water is forced out in a jet, as a result animal movement is known
as "Jet Propulsion". The jelly fish moves in jerks in the direction opposite to the
expelled water.

2. Locomotion in Snail:
Organs of Locomotion:
Snail crawl or move very slowly by "foot".
The foot of snail produces a wave of muscular contraction on its under side. This
wave is from front to rear and animal is pushed forward. The movement is
lubricated by slime which is poured on land immediately from glands below the
3. Locomotion in Star Fish:
Organs of Locomotion:
Starfish moves with the help of tube feet. The tube feet are present on both sides of
radial canal that extends up to the tip of arm.
Structure of Tube Feet:
The tube feet are hollow muscular and are like rubber bulb of the medicine dropper.
The tube feet consist of three parts.



In starfish locomotion is controlled by a special water vascular system. Water is
drawn into the body through a small opening and is passed through a ring canal to
large number of hollow muscular tube feet. The tube feet extend when water is
pumped into them then they fix themselves by suction cup (sucker) with some

object. When sucker muscle contract the water is pushed back into the ampullae,
making the tube feet flaccid losing the grip and the starfish is pulled forwards.

Biology XII (Notes)

Arranged By: Faisal Ahmed Jokhio

Plant Hormones: (Phytohormone)
Certain chemical produced by plants have profound effect on their subsequent
growth and development. Such chemicals are called Plant Hormones or
*Phytohormone are synthesized by plants in minute concentration and exert their
effect by activating gene expression or inhibiting enzyme or changing properties of

Types of Phytohormone:
There are five kind of plant hormones
1. Auxins
2. Gibberellins
3. Cytokinins
4. Abscisic Acid
5. Ethene

1. Auxins:

The first auxin was discovered by Fret Went in 1926.

Chemical Nature:
Indol Acetic Acid (I.A.A)
Indol Acetic Acid (I.B.A)
Nephthalene Acetic Acid (N.A.A)
Site of Synthesis:
It is synthesize at the apices of stem and foot, young leaves and young embryo.
Role of Auxin:
i. Cell division and cell enlargement
It stimulate teh cell division and cell enlargement and plant in increase the length of
ii. Initiation of Root
Auxins also initiates development of adventitious roots when applied at the cut base
of stem.
iii. Abscission
In mature leaves and fruits when auxin production diminishes, a layer of thin walled
cells is formed at the base of petiole and stake of fruit. This layer is called Abscission
layer and causes fall of leaves and fruit with slight jerk.
iv. Growth of Fruit
Auxins produced in young embryo promotes the growth of fruit.
v. Parthenocarpy
Use of auxin helps in producing parthenocarpic or seedless fruits.
vi. Apical Dominance
Besides growth promoting function on Auxin, also has inhibitory effect on growth.
Growth of apical bud inhibits growth of lateral buds beneath the stem. This
phenomenon is termed as apical dominance removal of apical buds initiates growth
of lateral buds with more leaves and axillary bud.
vii. Weedicide
Auxins are selective weed killer 2-4 dichlorophenoxy acetic acid (-2-4-D) is used to
kill weeds in lawn's and cereal crops.

2. Gibberellins:
Gibberellins was discovered by T.Yabuta and I.Hayashu in a fungus called
Gibberellins funjikuroi. This fungus causes foolish seedling (Bakanae) disease in
rice. In this disease the infected rice seedling elongated and ultimately fallover
without producing grains.
Chemical Nature:
The chemical nature of Gibberellins is Gibberellins acid 70 types of gibberellins
have been discovered.

Role of Gibberellins:
i. Cell division and cell enlargement
Like auxins Gibberellin also promotes cell division and elongation.
ii. Control of Dwarfism
Gibberellins can control genetic and physiological dwartism plants.
iii. Seed Germination
They promote the synthesis of a-amylase enzyme is dorman seeds due to the
production of this enzyme, the seed starts germination.
iv. Parthenocarpy
These hormones help in the formation of seedless fruit which are called
Parthenocarpic fruits.
v. Increase of Crop Yield
The crop yield of sugar can can be increased by the application of gibberellin about
50 tons/ acre.
vi. Formation of Flower and Growth of Pollen Tube
They stimulate flowering and the growth of pollen tubes during fertilization

3. Cytokinins:
Cytokinins are discovered by Miller in coconut milk.
Chemical Nature:
Chemically there are two types of cytokinins.
Kinetin It is found in coconut milk etc.
Zeatin It is found in maize.
Role of Cytokinins:
i. Cell Division
They initiate rapid cell division only in the presence of auxin.
ii. Delay in Senescence
They also caused delayed senescence (old age).
iii. Breaking of Seed Dormancy
They break seed dormancy and promote fruit development some species.

4. Abscisic Acid (A.B.A):

In contrast to growth promoting hormones, abscisic acid is growth inhibitor,
produced by plants during adverse environment conditions such as drought
Role of Abscisic Acid:
It increases dormancy in buds and seeds.

It causes stomata to close.

It turn leaf primordia into scale.

5. Ethene
It is a gas which also acts as a growth inhibitor.
Role of Ethene:
It triggers ripening of fruits.

It contributes in leaf abscission and also breaks the dormancy of seeds and

It also initiates flowering in plants e.g. pineapple.

Responses to Environmental Stress

Changes in environmental conditions are the big threats for living organisms
especially for plants. These factors which change the normal condition of light, CO2,
nutrients, temperature etc. causes severe stresses on plants. The common
environmental stresses for plants are
1. Water Shortage (Drought condition)
2. Less Oxygen Supply
3. High Concentration of Salt in the Soil
4. High Temperature
5. Low / Cold Temperature
6. Herbivory / Over Grazzing

1. Water Shortage:

In dry condition, the guard cells of leaf become flaccid to close the stomata.

In this way the transpiration is stopped.

The dry condition also stimulates increased synthesis and release of abscisic

This hormone help in keeping stomata close.

These plants produce deeper root system.

2. Oxygen Deficiency:

Those plants which grow in wet habitat or marshes, they develop aerial roots
to absorb oxygen.

Some plants developed air tubes that provide oxygen to submerged roots.

3. Salt Stress:

The plants especially halophytes, have salt glands in their leaves where
desalination occurs.

4. Heat Stress:
In plants there are two methods to tolerate the heat stress.
Transpiration has a cooling effect on the plant body. By this method the
effects of heat are reduced.

Above 40oC plants cell start synthesizing relatively large quantities of special
protein called heat shock proteins.

5. Cold Stress:

Plants respond to cold stress by altering the lipid composition, changes in

solute composition is altered also by producing different polymers of pentose
(Fructose) which allow the crystals to super cool without compound

6. Herbivory / Over Grazzing:

Plants overcome excessive herbivory by developing horns and production of

distasteful or toxic compounds.

Defence Against Pathogens

Diseases of plants may arise from infections by viruses, bacteria or fungi and other
pathogens in most cases. Against these diseases the plants produce immune system
in their body.
First Line Defence:
The outer layer epidermis is a protective covering around the body of plant. This is
the First Line Defence.
Second Line Defence:
When pathogens enter the body through stomata or any other way, then plants
produce certain chemicals to kill them. This is called Second Line Defence.
In infected plants an antibiotic phytoalexins is produced which is effective to all

Biological Clocks
A control system is found in all living organisms which controls physiological and
metabolic and metabolic functions according to time is called Biological Clock.

Biological Rhythms OR Biorhythms

In living things the behavior activities occur at regular intervals which are called
biological rhythms OR biorhythms.

Circadian Rhythms
[Circa => about; dies => day]
Biorhythms may occur, showing periodicity of about 24-Hours. These are called
Circadian Rhythm, which means about one day, so they are also called diurnal

Causes of Biorhythm:
Biorhythms occurs due to the following reasons.
1. Exogenous Stimuli
2. Endogenous Stimuli

1. Exogenous Stimuli:
There may be direct response to various changes in the external (exogenous) stimuli.

2. Endogenous Stimuli:
These rhythms can be controlled internally by an efficient time measuring system
and are independent of light and temperature effects. These types of rhythms are
called endogenous.

Co - Ordination
The working together of all parts of the body or system is called Co-ordination.

Types of Co-Ordination:

There are two types of Co-ordination.

1. Nervous Co-Ordination
2. Chemical Co-Ordination

1. Nervous Co-Ordination:
Co-Ordination brought about by the nervous system. It is quickest way of
communication take place by electro-chemical messages called Nerve Impulse
within the body of all animals is called Nervous Co-Ordination.

Elements of Nervous System:

The elements o nervous system which help in co-ordination are
i. Receptor
ii. Central Nervous System (CNS)
iii. Effector
i. Receptor:
The sensory tissues or organs which receive any change in their external as well as
internal environment (stimuli) are called Receptors.
ii. Central Nervous System:
The receptors convey the stimuli to the control centre, the nervous system (Central
Nervous System) through sensory nerves.
iii. Effector:
The central nervous system (CNS) analyses stimuli and sends an appropriate
command, through it motor nerves to either endocrine organ to release hormones
into the blood or to muscles called Effectors.

Pathway in Nervous System:

There are two types of pathway in the nervous system.
i. Afferent Nerve Pathway
ii. Efferent Nerve Pathway

i. Afferent Nerve Pathway:

From receptor the messages are carried to the Central Nervous System i.e. brain
and spinal cord, this pathway is called Afferent Nerve Pathway.

ii. Efferent Nerve Pathway:

From central nervous system the messages are transferred to the effector. This
pathway is called Efferent Nerve Pathway.

Nervous Tissues
There are two types of nervous tissues

1. Neurons
2. Neuroglia OR Glial Cells

1. Neurons:
The nervous system consist of special cells which can generate and conduct electric
current are called Neurons.
The chief structural and functional unit of nervous system is called Neurons.

Structure of Neurons:
Neurons are different from each other according to size and shape but the structure
of neuron consists of three parts.
i. Some or Cell Body
ii. Dendrites
iii. Axon

i. Soma OR Cell Body:

Each neuron has a cell body or soma containing nucleus and various organelle
embedded in the cytoplasm. Nissl's granules which are group of ribosomes,
associated with rough E.R. and Golgi apparatus are present in the cell body.
The cell body or soma is the main nutritional part of the cell necessary for
growth of neuron.

Soma receive message to dendrites and convey it to axon.

ii. Dendrites:
From the soma, a large number of small threads like terminal branches are arises
are called Dendrites.
Dendrites receive stimuli and convey it to the soma.

iii. Axon:
The unbranched, single elongated cytoplasm process which usually arises opposite
to dendrites called Axon.
Axon Hillock
Axon originates from a pyramid like area of soma called Axon-Hillock.
Axon Terminal
At the terminal end of axon many fine branches are present called Axon Terminals.
Myelin Sheath

The axon of some neurons is enclosed by a layer of fatty substance known as Myelin
Sheath. This serve as insulating layer.
Axon is specialized for conducting impulses to other neurons.

Types of Neurons:
According to the function, neurons are of the three types.
i. Sensory Neuron
ii. Motor Neuron
iii. Inter Neuron

i. Sensory Neuron:
The neurons which transmit impulses from receptor to the central nervous system is
called Sensory Neuron or Receptor Neurons.

ii. Motor Neuron:

The neurons which transmit instructions of the central Nervous System to the
effector are called Motor Neurons or Effector Neurons.

iii. Inter Neurons:

The neurons present between sensory and motor neurons are called Inter Neurons.
They are found in Central Nervous System.

Functions of Neurons:

Neurons is the functional unit of nervous system which receives stimuli,

transfers them to the Central Nervous System (CNS).

It transfers the messages from CNS to the body parts effector.

Reflex Action:
The automatic involuntary responses which occur either due to internal or external
stimuli are called Reflex Action.
An immediate response to a specific stimulus without conscious control is called a
Reflex Action.

Parts of Reflex Action:

Reflex action consists of
i. Receptor: (Skin) receive stimuli.
ii. Sensory Neuron: It carries message from receptor to the Central Nervous System

iii. Motor Neuron: It carries message from Central Nervous System (CNS) to the
iv. Effector: (Muscle of gland) which perform action.

Reflex Arc:
The pathway of passage in impulse during a reflex action is called Reflex Arc.
Reflexes may be monosynaptic or polysynaptic.
The reflex action in which only one synapse is involved is called Monosynaptic.
Example: Knee Jerk
The reflex action in which many synapses are involve due to presence of inter
neurons between sensory and motor neurons is called Polysynaptic.
Example: Hand withdrawal on the painful stimuli.

Examples of Reflex Actions:

If our hand touch any hot object, it is quickly withdrawn.

Secretion of juices from the gland.

Blinking of eyes.

Contraction and expansion of lungs.

If a strong light is flashed across the eye, the eyelids are at once closed or
start blinking.

Nerve Impulse:
The electrochemical signals developed by a neuron for communication is called
Nerve Impulse.

Method of Development of Nerve Impulse

The neurons develop impulse in the following way.
1. Resting Membrane Potential (RMP)
2. Action Potential
3. Propagation of Impulse
4. Synapse

Resting Membrane Potential:

A typical neuron at rest is more positive electrically outside than inside the cell
membrane. This net difference in charge between the inner and outer surface of a
non conducting neuron is -65mv is called the Resting Membrane Potential.

Factors Involved in Resting Membrane Potential

This popularity is due to the unequal distribution of ions across the neurolemma.
The major factors which are involved in resting membrane potential are
Sodium and Potassium Ions
There is a greater concentration of sodium ions outside than inside the

Similarly potassium ions are concentrated muscle inside than outside the

This is attributed to the activity of ATP driven sodium potassium pump in

the neurolemma.

Action Potential:
When neuron is stimulated reversal of the polarity of the neurolemma occurs, first
changes to +40mv and then restores to -65mv again is called Action Potential.
This action potential is extremely rapid as it occurs in a few milliseconds.

Factors Involved in Action Potential

Sodium and Potassium Ions
The change in potential across the membrane is due to the presence to
sodium and potassium channels in the neurolemma.

Changes Associated with Action Potential

Sequence of membrane potential changes associated with an Action Potential.
Resting Potential

Sodium gates open and Na+ diffuses into the cell causing a depolarization of
the membrane from negative to zero and then proceeds upto +40mv.

Sodium gates close and potassium gates open.

K+ diffuses out, causing a repolarization of the membrane.

Sodium potassium pump restores original ion gradients and resting potential.

Propagation of the Impulse

When the action potential develops and spreads along the entire length of
neurolemma, it is called propagation of nerve.

Definition :
The region where the impulse moves from one neuron to another is called a Synapse.

Components of Synapse
It consists of three components
1. Pre Synapting Membrane
2. Synaptic Cleft
3. Post Synaptic Membrane
1. Pre Synaptic Membrane:
The membrane of axon terminal is called Pre Synaptic Membrane.
2. Synaptic Cleft
The narrow space between neurons is called Synaptic Cleft.
3. Post Synaptic Membrane
The membrane of dendrites of another neuron is called Post Synaptic Membrane.
Motor End Plate:
When it is the membrane of muscle cell it is called motor end plate.
The chemicals present in the vesicles which are released at the axon ending of the
neurons, at synapse are called Neurotransmitter.

Mechanism of Impulse Through Synapse

When an impulse is reached at axon terminals, the calcium channels are


From synaptic cleft calcium ions are diffused into the calcium channels.

Due to this synaptic vesicles fuse with the pre-synaptic membrane, causing
the release of neurotransmitter molecules into the synaptic cleft.

The neurotransmitter bind to the receptors on the post-synaptic membrane,

which generate action potential in the post-synaptic cell.

The neurotransmitters are then reabsorbed by the pre-synaptic cells for


Examples of Neurotransmitter:
Many different types of neurotransmitter are known. These are acetylcholine,
norepinephrine, glycine, gab a, serotonin, dopamine etc.

Evolution of Nervous System:

In different group of animals two types of nervous systems can be recognized, which
1. Diffused Nervous System
2. Centralized Nervous System

1. Diffused Nervous System

Diffused Nervous System is found in cnidarians and Echinoderms.
Nervous System of Hydra
In these animals, no anterior and posterior ends is present and their body is
radially symmetrical.

The nerves cells are found in the form of network throughout the body.

The flow of information is not highly directional and it diffuses in all


The transmission of impulses is slow because of synapses involved.

There is no brain but the nerve cells constitute the nervous system.

2. Centralized Nervous System

Centralized Nervous System found to varying degrees in more complex organisms
from platyhelminthes to chordates including humans.
Nervous System of Planaria
In these animals, definite anterior and posterior ends is present and their
body is bilaterally symmetrical animals.

It consists of an anterior brains (a concentration of neurons) which is

connected with the Sensory Organs.

From the brain arise two cord like nerves running longitudinally through the

The two nerve cords are connected with each other at several points through
the transverse nerves.

They co-ordinated the movement of the two lateral sides of the body.

Nervous System of Man

The nervous system of man is the most advanced, highly developed. It controls all
functions of the body. It consists of two parts
1. Central Nervous System (CNS)
2. Peripheral Nervous System (PNS)

1. Central Nervous System (CNS)

The nervous system consists of brain and spinal cord (hollow nerve cord) and also
consists of upto 100 billion inter neurons is called Central Nervous System (CNS).
Components of Central Nervous System
The central nervous system consists of

Spinal Cord

Protection of Central Nervous System

Brain and spinal cord both are protected in three ways
i. Cranium
ii. The Vertebral Column
iii. Meninges
iv. Cerebrospinal Fluid (CSF)

i. Cranium:
Cranium, which is part of skill, protects the brain.
ii. Vertebral Column:
Neural arches of vertebrate of vertebral column protect the spinal cord.
iii. Meninges:
Beneath the cranium, the brain and spinal cord are protected by triple layers of
tough connective tissues called meninges.
iv. Cerebrospinal Fluid (CSF):
Between the layers of meninges, there is a plasma like fluid which bathes the
neurons of brain and spinal cord is called Cerebrospinal Fluid (CSF).
It cushions against the bumps and jolts.

2. Peripheral Nervous System (PNS)

The nerves arises from brain and spinal cord that are spread in various part of body
which transmits the signals between CNS and body parts make a nervous system
called Peripheral Nervous System.
The peripheral nervous system consists of two types of nerves.
i. Cranial Nerves
ii. Spinal Nerves

i. Cranial Nerves:
In humans, there are 12 pairs of nerves which arise from the brain or lead to the
brain these nerves are called cerebral or cranial nerves.

ii. Spinal Nerves:

In humans, there are 31 pairs of nerves which arise from the spinal cord or lead to
the spinal cord are called spinal nerves.

Types of Peripheral Nervous System

The peripheral nervous system is divided into two types according to their
1. Somatic Nervous System
2. Autonomic Nervous System

1. Somatic Nervous System:

The peripheral nervous system which controls all the voluntary activities of the
body such as contraction of skeletal muscles and movement of joint is called Somatic
Nervous System.

2. Autonomic Nervous System:

The autonomic nervous system which controls involuntary activities of the body

such as smooth muscles, glands, muscles of heart and other internal organs is called
Autonomic Nervous System.
Types of Autonomic Nervous System
Autonomic nervous system divided into two types
i. Para Sympathetic Nervous System
ii. Sympathetic Nervous System

i. Para Sympathetic Nervous System:

The autonomic nervous system formed by some cranial nerves, vagus nerves and the
spinal nerves that are arising from the sacral vertabrate are called Para
Sympathetic Nervous System.
ii. Sympathetic Nervous System
The autonomic nervous system whose nerves arise from the thoracic and lumber
regions of spinal nerves is called Sympathetic Nervous System.
This system is important during emergency situation and is associated with "flight
or fight". It increases the heart beat, breathing rate, slows digestion, dilates pupil

The most important part of Central Nervous System develops from dorsal, hollow
nerve cord well protected in the cranium of skull and composed of inter neurons
and is the seat of our intelligence, learning and memory is called Brain.

Parts of Brain
The brain consists of three parts
1. Fore Brain
2. Mid Brain
3. Hind Brain

1. Fore Brain
Fore brain can be divided into two regions
i. Telencephalon
ii. Diencephalon

i. Telencephalon:
The largest part of fore-brain which is differentiated into two cerebral hemisphere

or cerebrum is called Telencephalon.

Cerebrum is the largest part of the brain and is divided into two halves called
Cerebral Hemisphes.

Cerebral Hemisphere:
Each hemisphere consist of an outer grey matter or cerebral cortex and an inner
white matter.

Cerebral Cortex:

Cerebral cortex is the largest and the most complex part of human brain.

It is highly convulated to occupy the greater number of inter neurons.

Corpus Callosum:
The two cerebral hemisphere communicate with each other by means of large band
of axons called Corpus Callosum.

Parts of Cerebrum:
Functionally, the cerebrum is differentiated into four lobes.
Anterior Frontal Lobe

Lower Central Temporal Lobe Parietal Lobe

Dorsal Occipital Lobe

Function of Cerebrum:

Cerebrum is concerned with intelligence memory, learning, resoning and

overall control of all voluntary actions.

It involved in all conscious activities.

It co-ordinated different senses together.

2. Diencephalon:
The diencephalons consists of two parts
i. Thalamus
ii. Limbic System

i. Thalamus:
The clearing house for sensory impulses is called Thalamus.

It receives them from different parts of brain and relays them to the
appropriate part of the motor cortex.

It also involves in the perception of pleasure and pain.

ii. Limbic System:

The limbic system is located in an are between the thalamus and cerebrum.

Parts of Limbic System:

The limbic system consists of
i. Hypothalamus
ii. Amygdala
iii. Hippocampus

i. Hypothalamus
Hypothalamus is the part of limbic system which is called Thermostal of the body.
The hypothalamus is important in regulation of homeostasis.

It regulates pituitary gland.

It also regulate body temperature, blood pressure, hunger, thirst, aggression,

pleasure and pain.

ii. Amygdala
The amygdala produces sensation of pleasure, punishment or sexual arousal
It also involve in the feelings of fear.

iii. Hippoc Ampus

Hippocampus is involved in long term memory.

Mid Brain:
In mammals mid brain is relatively very small. It consists of the optic lobes which
are represented by four small bodies.
It receives sensory information like vision, odour etc. It receives sensory information
from spinal cord and sends them to the fore brain.

Hind Brain:
Hind brain consists of
1. Medulla Oblongata
2. Cerebellum
3. Pons
4. Reticular Formation

1. Medulla Oblongata:
Medulla oblongata lies on the top of spinal cord.
It controls involuntary actions like blood pressure, heart beat, sneezing,
coughing, breathing rate, hicupping, swallowing etc.

2. Cerebellum:
The cerebellum lies dorsally behind the optic lobes. It is highly convoluted. It is
large in mammals than other animal.
The cerebellum plays an important part in controlling muscular coordination.

It specially maintains balance and also position of the body in space.

3. Pons
Pons regulates activities like muscular co-ordination, facial expressions, breathing
and sleeping.

4. Reticular Formation
Reticular formation lies in pons, medulla and mid brain.
It monitors the messages to the brain which should be ignored or should be

Brain Stem:
The oldest tissues formed by the combination of medulla oblongata, pons and mid
brain is called as Brain Stem.

It involved in the control of sleep and wakening.

Spiral Cord
A thick whitish nerve cord that lies below the medulla oblongata and extends down
through the neural canal of vertebrate upto the hips is called Spinal Cord.

Cross Section of Spinal Cord

In cross section, the spinal cord is differentiated into two areas.
White Matter

Gray Matter

Unlike brain, spinal cord has grey matter inside surrounded by white matter on the
outside. They grey matter has the shape of an "H". The first synapse of each sensory
neuron is located in the grey matter.

Central Canal:
The narrow central containing cerebrospinal fluid runs through the middle of the
spinal cord. This fluid brings nutrients to the spinal cord.

Spinal Nerves:
The nerve arises from spinal cord is called Spinal Nerves.
Each spinal nerve divides into two roots just before it joins spinal cord.
1. Dorsal Root
2. Ventral Root

1. Dorsal Root:
The dorsal root joints the dorsal part of the spinal cord and it contains axons of
sensory neurons.
Dorsal Root Ganglion:
The cell bodies of these neurons aggregate in a small swelling known as the dorsal
root ganglion.

2. Ventral Root
The ventral root which is attached to the ventral part of the spinal cord carrying

axons of motors neurons, arised from the spinal cord.

Functions of Spinal Cord:

Spinal cord serves as an express way for signals between autonomic nervous

It is also the control centre for many reflexes.

The single or group of either modified neurons or epithelial cells which receive
stimuli either from external environments and relaying them in the form of impulses
to the CNS are called Receptors.

The receptors are acts as receptionist of nervous system because they receive any
kind of change, which is then transferred to the brain and spinal cord.

Receptor converts stimuli into nerve impulses, this stage awareness of stimulus is
called Sensation.

In the control centre of the nervous system, the impulses are converted into

Types of Receptors
Receptors are classified according to type of stimulus which they can detect and give
response. Following are some types of receptor.
1. Thermoreceptor:
The receptors which detect and respond to temperature fluctuations (heat and cold)
are called Thermoreceptor.
2. Chemoreceptor
The receptors which can detect and respond to presence of certain chemicals in their
surrounding are called Chemoreceptor.
3. Mechanoreceptor
The receptors which can detect the stimuli of sound, motion, touch, pressure gravity
and movement are called Mechanoreceptor.

4. Photoreceptor
The receptors which respond to the stimulus of light and ultraviolet rays are called
5. Pain Receptor
The receptors which produced sensation of pain or damage tissues are called the
Pain Receptor.

Working of Sensory Receptors in Skin

In human, the receptors in skin are concerned with at least five different senses i.e.,
touch, pressure, cold, warm and pain.

Types of Sensory Receptor in Skin:

There are two types of sensory receptors in the skin.
i. Free Nerve Ending Receptors
ii. Encapsulated Receptors

i. Free Nerve Ending Receptors

The simplest types of receptor which contain free end without any protective capsule
and are located just beneath the epidermis are called Free Nerve Ending Receptors.
Free nerve ending receptors adapt very slowly to stimulation.

They are of different types
a. Mechanoreceptors: Receive touch and pressure.
b. Nociceptors: Feel pain
c. Thermoreceptors: Feel change in temperature

ii. Encapsulated Receptors

The type of receptor contain a protective capsule of connective tissues at their ends
and lie in skin are called Encapsulated Receptors.
Encapsulated receptor are of following two types
i. Meissner's Corpuscles
ii. Pacinian Corpuscles

i. Meissner's Corpuscles:
The encapsulated receptors that are found in those parts which do not have hairs
such as finger tips, eyelids, lips palms, soles, nipples etc are called Meissner's


Structure of Capsule:
Their capsules consists of thick collagen fibers with spiral and highly coiled nerve
There are touch receptors means very sensitive to touch.

ii. Pacinian Corpuscles:

The encapsulated receptors which are found in dermis layer and also in some
internal organs and moveable joints are called Pacinian Corpuscles.

Their nerve endings are surrounded by an onion like capsule made of concentric
layers of membrane. Between the membranes fluid filled spaces are present.
They are pressure receptor and detect rapid and deep pressure changes produced by
vibration and touch.

Sensory Receptors with Reference to Arteries

The aortic arch and the carotid artery contain many receptor which are
They detect the pressure changes in arteries.
They detect the pulse pressure
These receptors transfer these changes to the medulla oblongata which controls
blood pressure.

Aortic Body and Carotid Body:

The aortic arch and the carotid sinus also contain chemoreceptor called Aortic body
and carotid body.
They are sensitive to CO2 concentration and hydrogen ion concentration of the
Arranged By: Faisal Ahmed Jokhio *Contect # 03142027382*

Effects of Drugs on Co-Ordination

A chemical substance that causes the specific physiological response in the body are
called drugs.
Many drugs are useful medically to treat emotional stress or certain illness.

Drugs which people take to alter the mood or emotional state affect body
functional interfering with the working of neurotransmitters.

Therefore their abuse often causes harmful effects.


It is a drug found in tobacco.

It acts as a stimulant and is widely used as a neurological agent.

Nicotine affects post synaptic membrane in CNS and PNS.

It minimize the action of acetylcholine on nicotine receptors. So it is

stimulant to nerve impulse.

It increase the heart beat, rate, blood pressure and digestive tract mobility.

Nicotine may induce vomiting and diarrhea.

It may cause water retention relation by kidneys.

It stimulate the nervous system thereby reducing fatigue, increasing,

alertness and improving the concentration.

Nervous Disorders:
The abnormalities appear in brain, spinal cord, central nervous system and
peripheral nervous system causes diseases called Nervous Disorders.
Some common disorders of nervous system are as follows
1. Parkinson's Disease
2. Alzheimer's Disease

3. Epilepsy

1. Parkinson's Disease:
It is a brain disorder.
It either caused by degeneration or damage of nerve tissues within the basal ganglia
of the brain.
It is characterized by involuntary tremors, diminishing motor power and rigidity. It
causes stiffness, weakness and trembling of the muscles. The mental faculties are not
Leopoda is the effective medicine which is helpful in minimizing the symptoms by
can not halt the degeneration of neurons of brain.

2. Alzheimer's Disease:
It is the progressive degeneration of neurons of brain, especially cortex and
There is a genetic pre-disposition to the disease in some people, so it tends to run in
Stages of Diseases:
The disease progresses in three broad stages.
First Stage:
At first, the patient notices his forgetfulness.
Second Stage:
In second phase, there is a severe loss of memory particularly for recent events.
Anxiety increases with sudden changes in mood.
Third Stage:
In the third and last stage the disease become severe. He losses memory, hears voices
or see faces in the absence of any person. This disease is called Hallucination. He
does not share his ideas and does not accept ideas of other persons, such disease is
called paranoid delusions.
The main symptom of the disease is the loss of memory called dementia.
Effective medicines should be used.

Psychological treatment is better to control the disease.

Personal care of patient is necessary otherwise he may get any harm.

Chemical Co-Ordination
The co-ordination brought about by the endocrine gland system. It is not very rapid,
but shows slow and prolonged effect takes place by chemical substances called
hormones and neurotransmitter within the body of all animals is called Chemical
* Endocrine glands secreat their secretions (hormones) directly into the blood
stream. They are transported by the blood to the target cells.

Types of Hormones
Chemically the hormones are organic compounds which are classified into three
1. Peptide Hormones
2. Modified Amino Acids Hormones
3. Steroid Hormones

1. Peptide Hormones:
The hormones which are composed of protein are called Peptide Hormone. There
are two types of peptide hormones.
i. Small Chain Amino Acids
ii. Large Chain Amino Acids
i. Small Chain Amino Acids:
The peptide hormones consists of small chain of amino acids are called Small Chain
Amino Acids.

Antidiuretic Hormone (ADH)


ii. Large Chain Amino Acids:

The peptide hormones consists of long chain of amino acids are called Large Chain
Amino Acids.


2. Modified Amino Acid Hormones:

The hormones consists of modified amino acids are called Modified Amino Acid



3. Steroid Hormones:
The hormones which are composed of lipid are called Steroid Hormones.




Hormone Action
To explain the action of hormones two models have been proposed.
1. First Model
2. Second Model
Similarity Between Both Models:
Both model agree that the plasm membrane of cells contain certain receptors to
accept the hormones.
Dissimilarity Between Both Models:
After receiving the hormones continue their way of action called signal transduction
pathway. It is different in both models.

1. First Model:
According to the first model peptide hormones are involved. The receptor molecule
is attached to an enzyme adenylate cyclase in the inner part of plasma membrane.
The hormone is attached to the receptor. By the activity of enzyme ATP molecule is
changed into cyclic adenosine monophosphate (AMP) in the cytoplasm. The cyclic

(AMP) acts as a second messenger and activates the particular enzyme which
actually helps in the function. Some other messenger molecules also take part in the

2. Second Model:
According to the second model, steroid hormones are involved. These hormones are
fat soluble, so they enter the cell directly through the plasma membrane, so they do
not need second messenger. In the cytoplasm they are attached to the particular
receptors which transfer into the nucleus. In the nucleus. In the nucleus hormone
receptor complex activities the genes due to which actual function is started.

Functions of Hormones:

They do not initiate new biochemical reactions but produce their effects by
regulating the enzymatic and other chemical reactions, already present.

They may either stimulate or inhibit a function.

Hormones may also control some long term changes, such as rate of growth,
rate of activity and sexual maturity.

Endocrine System
Endo => Inside => Krinein => separate i.e. to secrete.
In the body of vertebrates there are certain dustless gland which poured their
secretions (hormones) directly into the blood or in body fluids are called endocrine
glands or ductless glands constitute a system called Endocrine System.

Endocrine Glands of Man:

In the body of man and other mammals, following important endocrine glands are
mostly found.
1. Hypothalamus
2. Pituitary Gland
3. Thyroid Gland
4. Parathyroid Gland
5. Pancreas
6. Adrenal Gland
7. Thymus Gland
8. Pineal Gland
9. Gonads

1. Hypothalamus:
The part of forebrain which forms a connection between Nervous System and
endocrine system is called Hypothalamus.
The hypothalamus contains specialized nerve cells called neurosecretory cells which
produced two types of hormones.
i. Releasing Hormone
ii. Inhibitory Hormone
i. Releasing Hormones:
The hormones which are produced to increase the secretion of another glands are
called Releasing Hormones.
Releasing hormone control the secretion of hormones from pituitary gland.
ii. Inhibitory Hormones:
The hormones which are produced to prevent the extra secretion of hormones are
called Inhibitory Hormones.
Hypothalamus produced two hormones which are

Antidiuretic Hormones (ADH)

These two hormones are stored in the posterior lobe of pituitary gland.
2. Pituitary Gland (Hypophysis)
Pituitary gland is called "master gland" because it controls the secretion of other
endocrine glands.
The pituitary gland is located in the brain. It is attached to the base of
hypothalamus by short.
The pituitary gland is small pea size gland.

Lobes of Pituitary Gland:

Pituitary gland has three lobes
i. Anterior Lobe
ii. Median Lobe
iii. Posterior Lobe

i. Anterior Lobe:
Anterior lobe produces three types of hormones which are

a. Tropic Hormone
b. Growth Hormone or STH
c. Prolactin

a. Tropic Hormone
The hormones which control the activity of other hormones are called Tropic

Kinds of Tropic Hormone:

The tropic hormone secreted by the pituitary gland are as follows
Thyroid Stimulating Hormone (TSH)
It control the working of thyroid gland including secretion of thyroxin.
Adreno-Cortico Tropic Hormone (ACTH)
In controls the activity of outer part of cortex of adrenal gland.
Follicle Stimulating Hormone (FSH)
FSH in females stimulate follicle developing and secretion of oestrogens from the
In males it stimulates development of the germinal epithelium of the testis and
sperm production.
Leutinizing Hormone (LH)
This hormone helps in the formation of sperms and testosterone hormone in male.
In female it takes part in ovulation i.e. release of ovum from the ovary.

b. Growth Hormone OR Somatotropin Hormone (STH)

It regulates the normal growth by controlling many metabolic processes, such as
protein synthesis, involved in growth of bones and soft tissue.

c. Prolactin Hormone
This hormone stimulate mammary glands and production of milk.

ii. Median Lobe:

Median lobe produced one hormone called Melanocyte Stimulating Hormone
This hormone controls darkening of skin in many vertebrates. In human, very small
amount of MSH is produced by the anterior pituitary rather than median.

iii. Posterior Lobe

From posterior lobe of pituitary gland following hormones are secreted.
a. Antidiuretic Hormone (ADH)

b. Oxytocin

a. Antidiuretic Hormone (ADH):

It stimulates the re-absorption of water by tubules of kidney and thus decreases the
amount of urine passed.
b. Oxytocin:
It stimulates contraction of muscles of uterus during child birth and release of milk
during breast feeding.

Abnormal Conditions Due to Pituitary Gland:

Due to abnormal production of somato tropic hormone (STH) or growth hormone,
following abnormalities occur.
i. Gigantism
ii. Dwarfism
iii. Acromegaly

i. Gigantism:
It is disease of childhood.

It occurs due to over secretion of somatotropic hormones (STH) or growth hormone.

The affected individuals becomes abnormally tall.

ii. Dwarfism:
It is a disease of childhood.

It caused due to less secretion of somato tropic hormone or growth hormone.

The affected individuals becomes abnormally short.

iii. Acromegaly:
It is a disease of adulthood.

It occurs due to overproduction to somatotropic homrone (STH).

In this condition, hands, feet and jaw bones and cartilages and soft muscles become
larger in size and swollen.

3. Thyroid Gland:
Thyroid gland is located in the neck region in front of trachea. It consists of two
lobes, one on either side of trachea.

It is butterfly in shape.

It secreats three main main hormones.
i. Thyroxine or T4 (Tetra lodo Thyroxine)
ii. T3 (Tri lodo Thyroxine)
iii. Calcitonin

i. Thyroxine OR T4:

Thyroxin increases the metabolic rate and promotes both physical growth
and mental development.

It increases the oxygen consumption and production of heat.

ii. T3 Hormone:

Tri lodo thyroxine performs the same function as that of thyroxine or Tetra
lodo Thyroxine.

iii. Calcitonin:

Calcitonin plays and important role in calcium homeostasis.

Calcitonin is produced when calcium Ca++ level is increased in blood.

It respond to decreased the blood calcium level by stimulating the deposition

of excess calcium in bones.

Abnormalities of Thyroid Gland:

There are two conditions of abnormalities of Thyroid Gland.
i. Hyperthyroidism
ii. Hypothyroidism

i. Hyperthyroidism:
The state of over secretion of hormones by thyroid gland is called Hyperthyroidism.
Due to hyperthyroidism following symptoms usually appear.
High blood pressure

Increase body temperature

Intolerance to heat

Profuse sweating

Loss in weight etc

ii. Hypothyroidism:
The state of deficiency of T4 and T3 hormones is called Hypothyroidism.
It causes following diseases
i. Myxedema
ii. Goiter
iii. Cretinism

i. Myxedema:
It occurs in adult stage.
It occurs due to the deficiency of T3 and T4 Hormones
Myxedema produces following symptoms
Overweight (Obesity)

Loss of hairs

Dry Skin

Mental activity or body movement become slower

Intolerance to cold

ii. Goiter
It occurs due to deficiency of iodine in diet which results in decreased level of
thyroxin hormones (T3 and T4).

Thyroid gland works more than normal to produce more thyroxine. As a

result of which they become swollen and enlarged.

iii. Cretinism
It is disease of childhood.
It occurs due to deficiency of thyroxin hormone in early age, such persons are called
cretinism and the mechanism is known as cretinism.
This disease shows following symptoms
Mental retardation

Stunted growth

Physical weakness

Abnormal facial features

4. Parathyroid Gland (PTG):

Parathyroid glands are present in the neck regiort with two parts of thyroid gland.

Their size is like pea seeds.

Parathyroid gland secrete only one hormone called Parathyroid Hormone (PTM).


Parathyroid hormone plays an important role in calcium's homeostasis.

Parathyroid hormone is produced when calcium Ca++ level is decreased in


It response to increased the calcium ion in blood in two ways.

It increase the absorption of calcium ions in kidney.

It induces the bone cells (Osteoblasts) to released calcium from bones into the
blood. This process is called Demineralization.

Abnormalities of Parathyroid Gland

Abnormalities in parathyroid gland usually produces two diseases.
i. Tetany
ii. Rickets
i. Tetany:
Deficiency causes a drop in blood Ca++ which in turn leads to muscular tetancy.
ii. Rickets:
Over production would lead to a progressive demineralization of the bones similar
to tickets, as well as to the formation of massive kidney stones.

5. Pancreas:
Pancreas is a gland which acts as both exocrine and endocrine gland.

Pancreas is located in abdominal cavity below the liver.

Islets of Langerhans:
The cells of pancreas are called Islets of langerhans.
They perform the function of endocrine gland.

This is under control of the pituitary trophic hormones STH and ACTH and
responds directly to the level of blood glucose which is normally 90ms/100mg.

The islets of langerhans are of two distinct types.

i. Alpha Cells
ii. Beta Cells
i. Alpha Cells (-cells):
Alpha cells secreat hormone called Glucagon.
ii. Beta Cells (-cells):
Beta cells secreat hormone called Insulin.


It is secreted in response to decrease sugar level in blood.

It increase the blood glucose level mainly by promoting breakdown of

glycogen to glucose in the liver and muscles.

It also increase the rate of breakdown of fats.


It is secreted in response to increase sugar level in blood.

It decrease the blood glucose level mainly by following mechanism:

i. It increases glycogen synthesis in liver and also increasing cell utilization of

ii. It also stimulates both lipid and protein synthesis which reduces glucose level.
iii. Insulin inhibits the hydrolysis of glycogen in the liver and muscles.

Disorders of Insulin Deficiency:

Due to deficiency of insulin, a diseased appeared called Diabetes mellitus.
Diabetes Mellitus:
When there is deficiency of insulin, the amount of sugar is increased in blood, it is
called Diabetes Mellitus.
High level of blood sugar

Sugar in the urine

Disturbance of the body's osmotic equilibrium


Derangement of the nervous system

Types of Diabetes Mellitus:

There are two types of Diabetes Mellitus.
i. Insulin Dependent Diabetes
ii. Insulin Independent Diabetes

6. Adrenal Gland:
A pair of adrenal gland is present, one on the top of each kidney.

Each adrenal gland has two distinct parts
1. Adrenal Cortex
2. Adrenal Medulla

1. Adrenal Cortex:

The outer layer of adrenal gland is called Adrenal Cortex. It is controlled by the
adrenocorticotropic hormone (ACTH) secreted from Pituitary Gland.
Adrenal cortex produces many hormones which are collectively called as
These hormones are very important for regulating carbohydrates

They are also essential for maintaining mineral balance in the body.

The important corticosteroid hormones are as follows.

1. Cortisol
2. Aldosterone
3. Androgen

1. Cortisol:

This hormone is produced at the time of fever and diseases.

It converts protein of muscles into amino acids, which are changed into
glucose by the activity of liver.

In this way there is continue supply of energy in the body.

It reduces pain and inflammation in the body.

Over Secretion of Cortisol:

Over secretion of cortisol causes a disease called Cushing's Syndrome.
Cushing's Syndrome

Breakdown of Muscles


Deficiency of Cortisol:
Deficiency of cortisol causes a diseases called Addison's Disease.
It is due to defect in auto immune system.

Loss in weight


Low level o sugar

Low blood pressure


This hormone helps in the reabsorption of Na++ and Cl- ions by the help of

It raises the blood pressure and blood volume.


It causes development of the secondary male characteristics, such as hairs on

face, depending of voice and increase in muscle size. It is like a testosterone.

When their amount in female in increased, hairs are produced on the face of

2. Adrenal Medulla
The inner layer of adrenal gland is called Adrenal Medulla.
Adrenal medulla works under the influence of sympathetic nervous system.

Adrenal Medulla produces many hormones which are collectively called as
Emergency Hormones. Both are secreted in stress situation.
The important emergency hormones are
i. Adrenaline OR Epinephrine
ii. Nor-Adrenaline OR Nor-Epinephrine

i. Adrenaline OR Epinephrin:

It increase heart rate, amount of glucose in blood, rapid respiration and

metabolism during emotions and emergency.

It also takes part in the contraction of blood vessels in intestine and dilation
of blood vessels in muscles.

ii. Non-Adrenaline Or Nor-Epinephrine:

It also functions like epinephrine, but its main function is control of blood
pressure during fight and flight.

The over secretion of both these hormones causes high blood pressure.

7. Thymus Gland:
It is present in the upper region of thorax, behind the breast bone. It consists of two
parts which are attached together in the front region of trachea.

It secret hormone called Thymosine.

Thymosine controls the production of Thymphocytes and also their differentiation.
These are the cells of immune system and control the infection of virus bacteria.

8. Pineal Gland:
Pineal gland is a tiny gland present at the upper side of diencephalons in the brain.

Pineal gland secretes a hormone called Melatonin.


Metatonin regulates the seasonal reproductive cycles.

It also regulates the growth and development of gonad in many mammals.

It controls the sensation of light and darkness of eyes.

It produced a/c to the time of day, night or weather.

8. Gonads
The testes and ovaries also functions as endocrine glands and produce sex hormone
chemically sex hormones are steroids. Secretion of gonadial hormones is controlled
by gonadotropic hormones pituitary gland.

i. Testes:

Testes are the male reproductive organs.

Testes produced male sex hormone called Testosterone.

Tests is responsible of sexual maturity and development of secondary sexual
characts such as appearance of beard and moustache in males.

It also stimulates the growth of bones and muscles.

ii. Ovaries:
Ovaries are female reproductive organs but they acts as endocrine glands.
Ovaries secrete two hormones called as
i. Oestrogen
ii. Progesterone

i. Oestrogen:
Oestrogen causes development of female secondary sexual characters.
It also helps in thickening of the wall of uterus and prepare it for implantation of
fertilized ovum.
ii. Progesterone:
It is concerned with maintenance of pregnancy by preventing the contraction of
walls of uterus

Notes Arranged By: Faisal Ahmed Jokhio

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