Tadigadapa-Nsf Erc Proposal

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PI/PD Name: Srinivas Tadigadapa
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PI/PD Name: Lawrence Pick
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COVER SHEET FOR PROPOSAL TO THE NATIONAL SCIENCE FOUNDATION

PROGRAM ANNOUNCEMENT/SOLICITATION NO./CLOSING DATE/if not in response to a program announcement/solicitation enter NSF 15-1 FOR NSF USE ONLY
NSF 15-589 10/23/15 NSF PROPOSAL NUMBER
1606719
FOR CONSIDERATION BY NSF ORGANIZATION UNIT(S) (Indicate the most specific unit known, i.e. program, division, etc.)
EEC - ENGINEERING RESEARCH CENTERS

DATE RECEIVED NUMBER OF COPIES DIVISION ASSIGNED FUND CODE DUNS# (Data Universal Numbering System) FILE LOCATION
10/23/2015 3 07050000 EEC 1480 003403953 10/23/2015 4:07pm
EMPLOYER IDENTIFICATION NUMBER (EIN) OR SHOW PREVIOUS AWARD NO. IF THIS IS IS THIS PROPOSAL BEING SUBMITTED TO ANOTHER FEDERAL
TAXPAYER IDENTIFICATION NUMBER (TIN) A RENEWAL AGENCY? YES NO IF YES, LIST ACRONYM(S)
AN ACCOMPLISHMENT-BASED RENEWAL
246000376
NAME OF ORGANIZATION TO WHICH AWARD SHOULD BE MADE ADDRESS OF AWARDEE ORGANIZATION, INCLUDING 9 DIGIT ZIP CODE
Pennsylvania State Univ University Park
110 Technology Center Building
AWARDEE ORGANIZATION CODE (IF KNOWN)
University Park, PA. 168027000
0033290000
NAME OF PRIMARY PLACE OF PERF ADDRESS OF PRIMARY PLACE OF PERF, INCLUDING 9 DIGIT ZIP CODE
N237 Millennium Science Complex
University Park ,PA ,168022130 ,US.
IS AWARDEE ORGANIZATION (Check All That Apply) SMALL BUSINESS MINORITY BUSINESS IF THIS IS A PRELIMINARY PROPOSAL
(See GPG II.C For Definitions) FOR-PROFIT ORGANIZATION WOMAN-OWNED BUSINESS THEN CHECK HERE
TITLE OF PROPOSED PROJECT Engineering Research Center for Magnetics for Brain Interfaces,
Imaging, and Stimulation (MBRAIIS)
REQUESTED AMOUNT PROPOSED DURATION (1-60 MONTHS) REQUESTED STARTING DATE SHOW RELATED PRELIMINARY PROPOSAL NO.
IF APPLICABLE
$ 2 60 months 08/01/17
THIS PROPOSAL INCLUDES ANY OF THE ITEMS LISTED BELOW
BEGINNING INVESTIGATOR (GPG I.G.2) HUMAN SUBJECTS (GPG II.D.7) Human Subjects Assurance Number
DISCLOSURE OF LOBBYING ACTIVITIES (GPG II.C.1.e) Exemption Subsection or IRB App. Date
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HISTORIC PLACES (GPG II.C.2.j)
VERTEBRATE ANIMALS (GPG II.D.6) IACUC App. Date
COLLABORATIVE STATUS
PHS Animal Welfare Assurance Number
FUNDING MECHANISM Research - other than RAPID or EAGER A collaborative proposal from one organization (GPG II.D.4.a)
PI/PD DEPARTMENT PI/PD POSTAL ADDRESS
Electrical Engineering 237 Millennium Science Complex
PI/PD FAX NUMBER
University Park, PA 16802
814-865-7065 United States
NAMES (TYPED) High Degree Yr of Degree Telephone Number Email Address
PI/PD NAME
Srinivas Tadigadapa PhD 1994 814-865-2730 sat10@engr.psu.edu
CO-PI/PD
Lawrence Pick DPhil 2002 202-651-5497 lawrence.pick@gallaudet.edu

CO-PI/PD
Steven J Schiff PhD 1985 814-863-4210 sschiff@psu.edu
CO-PI/PD
Nian Sun PhD 2002 617-373-3351 nian@ece.neu.edu
CO-PI/PD
Dennis Sylvester PhD 1999 734-615-8783 dennis@eecs.umich.edu
Page 1 of 3
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AUTHORIZED ORGANIZATIONAL REPRESENTATIVE SIGNATURE DATE

NAME
Allison Eisenhower Electronic Signature Oct 23 2015 4:05PM
TELEPHONE NUMBER EMAIL ADDRESS FAX NUMBER
fm1207rrs-07
814-865-1579 alm25@psu.edu 814-863-0497

Page 3 of 3
Proposed Vision: Imagine a world where; the brain can be continuously monitored and brewing epileptic
electrical storms are foreseen and averted, signals from motor cortex region drive and manipulate prosthesis
using a minimally invasive two-way brain computer interface (BCI), and monitoring brain functions
provides us with tools for understanding the mind and thoughts. Now imagine accomplishing this without
implanting hundreds of needles into the brain, and maintained throughout someone's lifetime. Imagine brain
images acquired quickly and affordably with table top magnetic resonance imagers in remote areas of Africa
or rural intensive care units in the US, at a thousandth of the magnetic field strength and cost of current
devices. The vision of the Engineering Research Center for Magnetics for Brain Interfaces, Imaging, and
Stimulation (MBRAIIS) is to create the next generation, room temperature, BCI and imagery based on non-
contact or minimally invasive magnetics technology.
Intellectual Merit: MBRAIIS will deliver a minimally invasive magnetic two-way BCI for chronic
prosthesis control and operation as the primary outcome. Two non-invasive testbeds will also be
demonstrated: (i) Magnetic Epilepsy Cap and (ii) Ultra-Low Field Magnetic Resonance Imager (ULF-MRI)
for hydrocephalus imaging. Emerging MEMS magnetic technology is at the core of the ERC, having the
potential to realize room temperature, ultra-high sensitivity magnetometers and focal micromagnetic
stimulator arrays that will be incorporated into engineered systems for realizing non-contact, ambulatory,
and sustainable solutions for the recording, stimulation, and imaging of the brain. The demonstration of a
two-way magnetic interface that can be implanted in the inner table of the skull will be a transformative
development in minimally invasive BCI. The research will exploit emerging concepts in high-Q, magneto-
acoustic resonators, flexure gate transistors, and non-linear resonance phenomenon to realize
magnetometers with unprecedented low frequency sensitivities of <100 fT/Hz at room temperature.
Development of 3D microcoils and magnetoelectrically generated temporally varying magnetic fields will
induce electric fields from a distance of 0.2-2 mm for neuronal stimulation. Arrays of such magnetic
stimulators can be designed to enable manipulation of currents in very small regions of the cortex in a sub-
threshold manner - a novel breakthrough. The magnetic technology will enable development of new
adaptive noise and background field compensation for unshielded operation of the magnetometers. The
underlying adaptively shielded, room-temperature, ultra-high sensitivity, magnetic interface technology
integrates ERC objectives from cellular/mesoscale level of detection of non-propagating quasi-dc magnetic
fields in implants and caps to the RF signals from the brain tissue in ULF-MRI.
Broader Impacts: MBRAIIS will deliver sustainable technology for minimally invasive magnetic BCI that
will offer a next-generation solution for prosthesis control and operation. The epilepsy cap testbed is
expected to impact over 2.2 million US patients enabling ambulatory and sustainable monitoring for
improved diagnosis, therapy, and more accurate identification of seizure foci. ULF-MRI systems without a
large standing magnetic field offer safe imaging of patients with orthopedic and cochlear implants. As an
inexpensive, non-cryogenic technology it will revolutionize medical care by providing a sustainable
solution for widespread conditions such as hydrocephalus. This ERC will prepare the next generation
workforce in the interdisciplinary domain of neural engineering through comprehensive K-12,
undergraduate, graduate and post-doc level programs. Specific curricular impact will be achieved through
programs such as the MS in Neural Engineering. A new program on "Creative Expressions" and "Hands on
Activities" will focus on developing demos and art exhibits of MBRAIIS Engineering for museums. The
ERC will foster a climate of diversity and inclusion with evidence-based programming and leverage the
partnerships with Gallaudet and Tuskegee universities. The Innovation focus will leverage the Michigan
NSF-ICORPS program for improved outcomes. The ERC will emphasize an innovation culture inclusive
of all participants with specific programs on commercialization through transfer of technology to industry
as well as cultivation of start-ups. Leveraging the sustainable technologies of MBRAIIS, a global program
will be created to include visitor exchanges and research collaborations with partners in Uganda, Germany,
and the Netherlands.
1
TABLE OF CONTENTS
For font size and page formatting specifications, see GPG section II.B.2.
Total No. of Page No.*

Pages (Optional)*
Cover Sheet for Proposal to the National Science Foundation
Project Summary (not to exceed 1 page) 1
Table of Contents 1
Project Description (Including Results from Prior 10

NSF Support) (not to exceed 15 pages) (Exceed only if allowed by a
specific program announcement/solicitation or if approved in
advance by the appropriate NSF Assistant Director or designee)
References Cited 3
Biographical Sketches (Not to exceed 2 pages each) 10
Budget 0
(Plus up to 3 pages of budget justification)
Current and Pending Support 0
Facilities, Equipment and Other Resources 0
Special Information/Supplementary Documents 2

(Data Management Plan, Mentoring Plan
and Other Supplementary Documents)
Appendix (List below. )

(Include only if allowed by a specific program announcement/
solicitation or if approved in advance by the appropriate NSF
Assistant Director or designee)
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Complete both columns only if the proposal is numbered consecutively.

ENGINEERING RESEARCH CENTER FOR
MAGNETICS FOR BRAIN INTERFACES, IMAGING AND STIMULATION (MBRAIIS)
THREE PLANE STRATEGIC PLANNING CHART
1
1. Proposing Team
Tadigadapa, Srinivas Penn State U. Electrical Engineering MEMS & Systems Integration
Schiff, Steven Penn State U. Eng Sci & Mech; Medicine Neurosurgeon, Neural Eng., MRI
Sylvester, Dennis U. of Michigan Elec. Eng. & Comp. Sci. Interface Circuits, VLSI
Pick, Lawrence H. Gallaudet U. Psychology EEG, Neurophysiology
Sun, Nian X. Northeastern U. Elec. & Comp. Eng. Multiferroics, Magnetic Sensors
2. Vision
Imagine a world in which the workings of the brain can be continuously monitored, where the brewing
epileptic electrical storms are foreseen and averted, signals from motor cortex region drive and manipulate
objects by robotic arms, and monitoring the inner workings of the brain provides us with tools for
understanding the mind and thoughts. Now imagine all this can be accomplished and maintained throughout
someones lifetime without implanting hundreds of needles into the brain. Furthermore, imagine images of
brains acquired quickly and affordably with table top magnetic resonance imagers (MRI) in remote villages
of Africa or for radiationless evaluation in neonatal intensive care units in the US, at a thousandth of the
magnetic field strength and cost of existing MRI devices. This 10-year vision of this Engineering Research
Center is to create the next generation brain-machine interfaces and imagery based on non-contact
magnetics technology that is ready and awaiting to be 1 GHz
20T 850 M Hz
HIGH FIELD MRI
embraced through MBRAIIS.
14T
128 M Hz 3T
100 M H z
The confluence of emerging micro- and nanoscale 10 MHz

General Characteristics:
1. Room Temperature Sensors
2. Arrays
fabrication techniques and the developments in high- 1 MHz
Theranostics
3. Sensitivity
4. Shielding & Compensation
performance magnetic, electronic, and piezoelectric ULF-MRI

Frequency
100 kH z 100 500 kHz
materials offer opportunities for room temperature magnetic 10 kH z
sensing technologies capable of recording magnetic signals 1 kH z
emanating from the brain and to serve as primary sensors of 0.1 1000 Hz
100 H z
EPILEPSY
MRI signals for brain imaging. This ERC will deliver
REST-STATE
10 H z
Motor Prosthetics - Sensing
M EG
sustainable and cost-effective magnetics technology for 1 Hz Motor Prosthetics - Stimulation

0.1 200 Hz EVOKED & EVENT RELATED POTENTIALs
brain recording, stimulation, and imaging for multiple brain 0.1 H z
0.1 fT 1 fT 10 fT 100 fT 1 pT 10 pT 100 pT 1 nT 10 nT
activities and ultra-low field magnetic imaging (Fig. 1). This Magnetic Field
vision will be accomplished through synergistic Fig. 1: Magnetic fields and frequency signals from
collaboration of Penn State as the lead institution and our the brain and in magnetic imaging systems.
partner institutions Gallaudet University, Northeastern
University, Tuskegee University (HBCU), and the University of Michigan.
Magnetic Brain Recording: Electrical interfaces for brain have
been explored for over 50 years. However: (i) making good brain
contacts; (ii) electrode implant corrosion and encapsulation in
implanted versions; and (iii) surgical complications associated with
repair and replacements have posed formidable challenges[1-4].
Magnetoencephalography (MEG) can overcome these limitations
and offer excellent temporal and good spatial resolution. MEG
depends upon sources to which electroencephalography (EEG) is
relatively insensitive [5, 6] and because brain contact is not required,
Fig. 2: Somatosensory and Motor Cortex safer placement in or just beneath the skull is possible something
areas of the brain.
no other technology on the horizon offers for prosthetic interfaces.
The most accessible human motor and sensory cortices are the primary hand areas (Fig. 2), having the
greatest near-term promise for an interface for upper extremity prosthetics [7]. Thus MEG provides an
advantageous and transformative alternative for brain monitoring.
13
MicroMagnetic Brain Stimulation: MBRAIIS will
advance the next generation brain computer interface
(BCI) enhanced by micromagnetic stimulation (PMS)
from microscale devices capable of neural stimulation in
a specific focal region. Compared to other methods,
PMS techniques have four advantages: (i) spatial
resolutions of 0.1 1 mm; (ii) integration with magnetic
recording; (iii) intra-skull placement as opposed to in-
brain (parenchyma) implantation; and (iv) chronic
implants without performance degradation. Fig. 3 shows
current techniques for brain stimulation with the blue
box highlighting region of interest for BCI applications
[8].
BCIs give users communication and control channels Fig. 3: Comparison of various neural stimulation
that do not depend on peripheral nerves and muscles (the techniques. Typical probe size and power are also
listed. Stars indicate non-invasive methods.
brains normal output channels) and augments options
for those with severe motor disabilities [1, 9]. Current BCIs use EEG activity recorded at the scalp or single-
unit activity recorded from within cortex to control or operate a neuroprosthesis. Like the brains normal
output channels, BCI is likely to engage the brains adaptive capacities, which adjust output based upon the
received feedback to optimize performance. An effective BCI must provide user feedback in order to
substitute for the missing or paralyzed part of the brain-computer conversation. For example, auditory
prostheses research has shown that large populations of cells in the auditory system will modify their tuning
specificity in response to electrical stimulation [10]. Thus a two-way BCI is needed. Integrated
magnetometers and PMS with their placement overlying the motor and somatosensory cortices (see Fig. 2)
respectively can create this Neuromagnetism, Magnetoelastic, Micromechanical, Simulation & Modeling, Packaging, Interface Circuit Design,
interface. Adaptive SNR Improvement, Image Processing, Magnetic Materials, Biocompatibility, Pulse shaping and control
Preliminary Neuron Stimulation Experiments
3. Strategic Plans Sensor & Array Packaging 100 fT 10 fT

MEMS
1 nT 500 pT Magnetometer Chips
Organization and Teaming: Interface Electronics
Biocompatibility Studies and Regulatory
Prosthetic Control using Magnetic 2-

Magnetometers
Integration of Magnetometer and
This ERC will focus on the only 100 pT 10 pT 10 pT 1 pT 1 pT 100 fT

MRI Systems
possible non-contact modality Integration
Stimulator Arrays
Unshielded, Adaptively
MEMS Magnetometer Arrays
Way Interface
for two-way interfacing with the Noise Com pensated Sensors
brain. Our approach has the

Hydrocephalus
Interface Electronics
potential for creating viable and
Imaging
MEMS, Electronics, Power
System Integration
Sensor Level Packaging

sustainable brain interface
solutions capable of chronic Micro-Stimulator Arrays
Micromachined Electromagnets
monitoring and low-cost Magnetoelastic D evices
Epilepsy
imaging systems. The ERC Sensor Level Neuron Slice 2-Way Micro-
Cap
Animal Stimulation Magnetic Interface

mechanism is necessary for Seizure Tests Experiments Chip Mice Testing
accomplishing the challenge of Pre-ERC Years 0 3 Years 3 5 Years 5 8 Years 8 - 10
creating room temperature fT
resolution magnetometers, for Fig. 4: Timeline and interactions among testbeds and research thrusts.
it is formidable and will require a simultaneous, interdisciplinary collaborative effort by our team of
engineers with diverse expertise. The proposed magnetometers are very different from any of the work that
has been done thus far. Figure 4 shows the detailed interaction between various thrusts and testbed activities
and how all of these tie together through the timeline with various magnetometer sensitivities. The proposed
scope of engineering solutions cannot be sustained or implemented through small and individual research
grants. A sustained 10-year effort with a systems driven comprehensive research plan and a commensurate
level of funding is necessary to accomplish these goals. At the end of the research period, the developed
magnetic brain interface will offer a viable and sustainable technology providing a currently needed but
unavailable solution for interfacing and imaging the brain.
3
The overall technical, workforce development, and
innovation ecosystem goals and activities of this ERC will
be coordinated and managed by Tadigadapa, PI and Center
Director. The research strategy is motivated by the
integrative testbed to demonstrate a two-way magnetic
interface consisting of both recording and stimulation
devices placed on the inner table of the skull for prosthetic
control. The ambient field compensated magnetometers that
will be developed as part of this testbed can be
opportunistically configured simultaneously to advance two
synergistically-associated testbeds: (i) MEG Epilepsy Cap
and (ii) Room Temperature ULF-MRI for hydrocephalus
imaging. All the systems level testbeds will be realized
through the foundational thrusts: (i) ultra-high sensitivity,
room temperature MEMS magnetometers; (ii) magnetic
stimulator chip technology; (iii) low-power sensor circuit
including adaptive field compensation and noise reduction
strategies; (iv) cellular, slice, and brain level interfacing and
stimulation; and (v) device packaging and biocompatibility.
Sensitivity, systems level specifications and packaging
requirements of the magnetic interfaces distinguishes the
effort between the testbeds. The two-way magnetic brain
interface chips are expected to have the most stringent
biocompatibility, form factor, and regulatory requirements. Fig. 5: Team expertise and organization structure
of the ERC with respect to the 3 testbeds.
A comprehensive plan focused for creating next generation
workforce in the interdisciplinary area of neural engineering will be developed from K-12, undergraduate,
and graduate levels. A comprehensive diversity and inclusion plan will be embraced throughout the ERC
institutions leveraging our partners Gallaudet and Tuskegee. Innovation and commercialization thrusts will
be an integral part of the ERC and will leverage the Michigan NSF-ICORPS program for improved
outcomes. Fig. 5 shows the three testbeds and the various thrusts of this ERC. The associated thrust leaders
and team members and their institutions are identified by colored tags and grouped according to their
expertise in the legend above. Our team will work seamlessly through regular weekly conference calls,
project updates, seminars, and workshops. These activities will target all aspects of the technical and
professional development activities and align them with MBRAIIS research and the innovation ecosystem.
Figure 5 shows the detailed interaction between various thrusts and testbed activities and how all of these
tie together through the timeline with various magnetometer sensitivities. Through MEMS design and
materials (Tadigadapa, Sun, Gianchandani), signals and control systems (Schiff, Sylvester, Blaauw), low-
power interface electronics designs and CMOS implementation (Sylvester and Blaauw), and packaging
and systems integration (Tadigadapa, Gianchandani) expertise we have assembled a comprehensive team
to deal with this challenge. In the area of low field imaging we have the most accomplished ULF-MRI
scientists and engineers on our team (Espy, Savukov, and Neuberger). Furthermore, all of these
engineering solutions have to be brought together to demonstrate application and solutions for specific
neurological disorders. We have a team consisting of Neurosurgeon (Schiff), Neurophysiologist (Pick),
cochlear implants, hearing and language expert (Garrido-Nag), epileptologist (Gilliam) who would be
providing design space guidance, specifications, efficacy evaluation, and feedback as we journey through
this exciting engineering expedition. The proposed scope of work and engineering solutions cannot be
sustained or implemented through small and individual research grants. This work requires deliberate
effort on part of an interdisciplinary team brought together through the ERC program to accomplish the
required targets. A sustained 10 year effort with a comprehensive research plan and a commensurate level
of funding is necessary to accomplish the stated goals.The overall technical, workforce development, and
innovation ecosystem goals and activities of this ERC will be coordinated and managed by Tadigadapa
4
who will serve as the Center Director. The research strategy is motivated by the two testbeds: (i) MEG
Epilepsy Cap and (ii) Room Temperature ULF-MRI for hydrocephalus imaging. The two systems level
testbeds will be realized through the foundational thrusts: (i) ultra-high sensitivity, room temperature
MEMS magnetometers, (ii) adaptive field compensation and noise reduction strategies, and (iii) low-
power sensor circuit and signal processing interface and implementation of model-based super-resolution
image reconstruction. The ultra-high sensitivity magnetometer thrust will be led by Nian Sun
(Northeastern) with his unique expertise in magnetic materials and sensor development. The background
field compensated magnetometer thrust will be led by Steven Schiff (Penn State) who is an expert in the
field of control engineering. The sensor interface circuit and signal processing thrust will be led by Dennis
Sylvester (Michigan). He has done pioneering research and development in the field of low power
interface circuits. The three thrusts will be in turn enabled by fundamental research plane where various
magnetic materials, micro and nanofabrication processes, stress compensation, pulse shaping control, and
fundamental questions relating to the generation of neuromagnetic fields and source reconstruction will be
addressed. We will leverage the EEG expertise and data from Gallaudet (Pick and Garrido-Nag) on
cochlear implant subjects and on Epilepsy (Gilliam- Penn State) as we build the foundation for MEG
based studies. Fundamental research plane topics will be addressed by the entire team distributed across
all the participating groups so as to achieve the necessary building blocks for each of the thrusts. As
shown in Fig. 5, for each decade of sensitivity improvement of the magnetometer arrays, we will
undertake relevant systems integration and packaging tasks that would ultimately enable the realization of
the two testbeds.
Background and State of the Art: Typical neuromagnetic fields are in the range of (10-12 T) pT (10-15
T) fT, making their detection against the background of earths and human generated magnetic fields (~
several tens of PT) challenging [5]. Only two kinds of devices have adequate sensitivity to achieve
neuromagnetic field measurements. First are the Superconducting Quantum Interference Devices
(SQUIDs), which require cooling to 4 K using liquid helium [11]. In human MEG, SQUID sensors are
typically set 1-2 cm from the head in a thermally-insulated Dewar, and such recordings are made in a
magnetically shielded room [12]. The cost of the MEG systems and the shielded rooms are ~$10 million
and also require access to liquid He. The alternative, Atomic Magnetometers (AM), use lasers and operate
by vaporizing alkali metal atoms at temperatures between 150-180 C [13]. The risk of implanting devices
containing hot alkali metal vapors or cryogenic SQUIDs remains prohibitively beyond risk tolerances for
any foreseeable human use. Recently, studies on Magnetoelectric Effect (ME) sensors have sparked interest
in low cost, room temperature and ultra-sensitive magnetometers [14, 15]. Our team has explored room-
temperature, chip-scale magnetic sensing technologies based on MEMS bulk acoustic wave resonators with
low-frequency sensitivities of 300 pT/Hz (Fig. 6) [16-21].
5
Our team has also developed a process (Fig. 7) for incorporating
Au-In eutectic bonding, which addresses the challenges of
integrating bulk magnetoelastic foils with micromachined
silicon structures [22, 23]. These results demonstrate that our
team can offer independent strategies to develop high sensitivity
magnetometers, and fabricate them as spatial arrays that are suffi
cient for future cellular level resolution. However, the current
challenge of achieving sensitivities of 100 fT/Hz using room
temperature MEMS devices will be explored through novel
designs and phenomenological explorations as part of this work.
Magnetic stimulation of neuronal tissues has been explored
including designs for focal stimulation [24]. Focused magnetic
brain stimulation can be attained using multiple small coils
instead of one large coil with the resultant induced electric field
being a superposition of the fields from each coil. In particular,
spherical coils, an idealized form of inductor, on a spherical
surface and consisting of a single-layer winding of constant
axial pitch, provides a very uniform magnetic field within the
coil [25]. This property of the coils can now be effectively
exploited using MEMS technology that can provide such z-axis
oriented uniform fields in a small footprint of 100 500 m.
Fig. 6: Two of the MEMS resonator based Fig. 8 shows the optical picture of our first microfabricated
magnetometer devices reported by our team.
hemispherical dome with a copper inductor coil patterned on it.
An 8 turn, 1 mm diameter coil can generate fairly uniform fields for
stimulation within the hemisphere at ~1 PT/mA. This can be increased by a
factor of 100x by coating the hemispheres with high permeability thin films.
These magnetic fields are highly confined to within the hemisphere and can
also be used to locally compensate the background magnetic fields around
individual sensors without affecting the nearby neighbors a very unique
feature of the proposed design. Furthermore, as magnetic stimulator chips,
these coils can be designed to create fine-grained patterns of changing
magnetic fields enabling us to manipulate currents within very small regions
of the cortex in a sub-threshold manner. Placing such structures in proximity
to each other in predesigned layouts will enable local regions to be stimulated Fig. 7: (a) Schematic and (b)
and modulated at the cellular level. SEM image of micro-
Compelling New Ideas: At the heart of this ERC is the emerging MEMS machined silicon-integrated
with Metglas.
magnetic technology that has the potential to realize room temperature ultra-
high sensitivity magnetometers and focal stimulator
arrays that will be incorporated into engineered systems
for realizing non-contact, ambulatory, and sustainable
solutions for the recording, stimulation, and imaging of
the brain. We will be exploiting novel concepts to
realize magnetometers with low frequency sensitivities
to below 100 fT/Hz. We will couple high Q-factor bulk
acoustic resonators made from quartz, aluminum
nitride, and langasite with highly magnetostrictive
Fig. 8: 3-D micromachined glass hemispherical dome FeGaB and Fe85B5Si10 thin films to measure the
with copper inductor coils patterned atop these glass magnetic fields through 'E effect [17],
structures. Experimental results of the field generated at
1.1 mm from the coil and COMSOL simulation.
magnetoflexoelastic effect [19] or ferrofluids [21]. We
will also explore non-linear and parametric resonance
6
phenomenon to achieve the proposed sensitivities. Alternatively, we will fabricate magnetoelectric flexure
gate transistor based magnetometers [26]. Such a transistor with < 500 nm of gap is predicted to measure
100 fT/Hz (Fig. 9). Integrating magnetoelectric composite materials directly with silicon will reduce
device sizes, lower noise floors through higher Q, localize signal processing, and enable servo-controlled
functionality. This technology platform will provide the impetus for (i)
full CMOS processing alongside the material integration and (ii) scaling
of the techniques to wafer-level integration, critical for achieving low-
cost arrayed systems with required spatial resolution. It will lead to high-
performance magnetic microsystems and provide capabilities in
adaptive noise compensation and feedback control that can be leveraged
in the proposed testbeds.
Development of 3D coils and magnetoelectrically generated temporal
magnetic fields will be explored to induce electric fields of 1 V/cm 10
Fig. 9: Predicted magnetic field
V/cm at a distance of 0.2 2 mm for neuronal stimulation. Along with sensitivity for a magnetoelectric
the magnetometers these chips can provide a common platform upon flexure gate transistor.
which both recording and stimulation devices can be integrated to realize
a two-way brain interface. These MEMS fabrication processes are just emerging and our team has unique
capabilities to realize such precise inductor coils. The fabrication processes for MEMS scale toroidal and
hemispherical structures create inherently symmetric devices that are naturally tolerant to imperfections.
No one has performed sub-threshold modulation of neuronal circuitry using fluctuating magnetic fields, but
we have pioneered the use of mapped electrical field sub-threshold control of neuronal circuitry [27, 28],
and are presently incorporating new technology, into model-based control systems [29]. This is an entirely
different approach than the current instantiation of transcranial magnetic stimulation, used as a spatially-
crude high-amplitude supra-threshold stimulation technology. Our final deliverable will be a prototype fully
integrated, high-density array of magnetic stimulators and adaptively shielded magnetic sensors including
stimulation artifact removal. In summary, this ERC will create next generation magnetics technology
for brain applications.
In addition to the two-way magnetic interface for prosthetic control, the room temperature magnetometers
developed in this work will be used in two non-invasive applications: (i) Magnetic Epilepsy Cap and (ii)
Ultra-Low Field Magnetic Resonance Imaging (ULF-MRI) for hydrocephalus imaging. These testbeds will
be highly impactful collateral outcomes on the engineered systems plane of the Center. Epilepsy is the 4th
most common neurological disorder and its prevalence and cost of $12.5 billion/year are staggering [30].
Current diagnosis relies upon patient self-reporting and limited testing/observations using EEG and MRI.
These tests are constrained to a limited time, often resulting in non-optimal: (i) selection and diagnosis of
potentially curable patients for surgery and (ii) prescription of anti-epilepsy drug dosage. Clearly an
ambulatory, sustainable, long term epilepsy monitoring solution is highly desirable. Robust low-cost MRI
designs using a pre-polarizing, strong magnetic field followed by a weak readout field was described in
1993 [31]. Achieving adequate sensitivity of detection and signal to noise ratio (SNR) in <100 mT magnetic
field MRI is a difficult technical challenge. MRI systems without a large standing magnetic field would
have the advantage of safe imaging of patients with orthopedic and cochlear implants and other hardware.
MBRAIIS will demonstrate this inexpensive, non-cryogenic, technology capable of revolutionizing
medical care and providing a sustainable solution for hydrocephalus imaging. It must be emphasized that
the underlying adaptively shielded, room temperature, ultra-high sensitivity magnetic interface technology
ties this ERC together seamlessly from cellular and mesoscale levels of detection of non-propagating quasi
DC magnetic fields in implants or caps and the RF signals from the brain tissue in ULF-MRI.
What has been recently funded: NSF has recently funded an ERC on Translational Applications of
Nanoscale Multiferroic Systems (TANMS) and another Center for Sensorimotor Neural Engineering
(CNSE). TANMS specifically focuses on multiferroic nanoscale devices for memory, antenna, and motor
applications and does not include magnetometers or magnetic brain interfacing and imaging technology.
CNSE is exploring two-way brain machine interfaces for sensorimotor applications exclusively through
7
EEG/electrical interface. MBRAIIS has a significantly different focus where MEMS magnetometer and
adaptive field compensation techniques will be explored to create sustainable solutions for the brain. Our
ERC is complementary to both centers and the synergies between these could be mutually leveraged in
advancing the goals of all three centers. DARPA and NIH also have investments in creating solutions for
brain interfaces. These are either focused on alternative methods at demonstrating sub- and single cellular
resolutions or at improving the reliability and sustainability of implantable electrical recording devices.
4. Research
The full integration of MBRAIIS research activities are shown in the 3-Plane Chart on Page 1 of Project
Description. In this context, the detailed description of the testbeds is discussed next.
Two-way Magnetic BCI for Prosthetic Control Testbed: We will use a top-down systems approach for
achieving our project goals. Accordingly, we will begin with detailed magnetometer and stimulator
performance specifications for achieving the intra-skull implantation of the two-way magnetic BCI just
above the somatosensory and motor cortices. This will include detailed calculations of the neuromagnetic
fields under various brain conditions. Thermal budget limits for the stimulator coils will be simulated using
detailed heat sink capabilities of the blood-rich skull environment and investigations of optimal magnetic
pulse strengths and frequencies. Biocompatibility and regulatory requirements will be set forth at the outset
to enable rapid translation into testbed demonstrations. The overall strategy will be to progress in a
systematic manner with the magnetometer and stimulator chips development beginning simultaneously.
The magnetometers thrust will be led by Sun. Research will explore various sensor designs, modalities, and
materials to cover the range from10 nT/Hz <100 fT/Hz. Lower sensitivity magnetometers will allow
for interface circuit design team to define their strategies for the next generation devices through detailed
specifications of the frequencies, input impedances, ambient noise etc. The interface electronics thrust will
be led by Sylvester. Through each tenfold of sensitivity improvement the challenges in stress control in the
deposited films, fabrication innovations, modeling and materials data will be systematically approached. In
the initial phase, we will test using pyramidal cells (coronal slices from animal sensorimotor cortex) by
performing single and dual-neuron intracellular stimulation by measuring the transmembrane voltage
generated by our magnetic stimulation the electrical analogs of which we have already reported [32, 33].
We performed the first subthreshold strength suppression of neuronal activity during seizures [27]. In what
we propose, we will now have the technology to perform a magnetic version of this previous electrical field
work. In the cortex and hippocampus, excitatory and inhibitory neurons can be orthogonally aligned [34],
have different geometries, and different characteristic frequencies [35]. We can use sensor array data to
construct matched filters to develop characteristic magnetic signatures of specific neuronal types to
disambiguate which neuron fired. Leveraging our existing collaboration, we will appoint one of the
foremost experts in the field of neuromagnetism and magnetic biophysics as an advisor for these
measurements and designs [36, 37]. Once these experiments confirm the efficacy of the developed
stimulator and magnetometer arrays, we will use integrated versions of the magnetic interface chips on the
somatosensory and motor cortices to demonstrate prosthetic control application. The prospect of interacting
with primary sensory and motor cortices such as the leg motor and sensory regions within the
interhemispheric fissure (Fig. 2), primary visual cortices along the banks of the calcarine fissure, and the
primary auditory cortices along the banks of the Sylvian fissure (of interest to our Gallaudet University
partner) becomes of substantial value. The tangential orientation of the principal cells of these cortices
actually is favorable for radially-oriented magnetic fields, and the interface chips can be positioned above
the layer of dura or skull inner table in a position that is non-brain invasive. These neuroprosthesis
demonstrations will be performed first on animal models collaboratively with affiliated partners. The
demonstration of a magnetic two-way interface that can be implanted in the inner table of the skull for
neuroprosthesis control and operation will be a transformative development in minimally invasive BCI.
Magnetic Epilepsy Cap Testbed: As we successfully demonstrate each generation of magnetometers in
the BCI testbed, they will be opportunistically configured to become the foundational steps for this
synergistically-associated testbed. We will explore uncharted magnetoelastic ferromagnetic materials
interactions in resonant devices, non-linear and parametric resonance phenomenon, and higher order
8
nonlinear elastic effects to design the higher sensitivity magnetometers.
Adaptive background field and noise compensation techniques will be used
in all magnetometers based on gradiometry or feedback on-chip field
generation. The approach of local magnetic field generation around the
sensors with feedback loops to achieve such compensation is unprecedented.
Through chip level integration of hemispherical coils on magnetometers and
combining with interface circuits, such devices will be demonstrated. The
ultimate goal of the epilepsy cap will be achieved through a leadership group
since the cap will need expertise in neural measurements, magnetometers
and interface circuits, packaging, and ergonomics and regulatory
Fig. 10: (a) PMRI System at
requirements Penn State. (b) Optical Image
Hydrocephalus Imaging using ULF-MRI Testbed: The next generation and (c) MRI Image of 8
magnetometers from MBRAIIS and the existing Penn State collaboration Eppendorf vials filled with 1
ml of 1 mM CuSO4 solution.
with Los Alamos National Laboratory (LANL) presents an opportunity to
make significant advances in this synergistically-associated testbed of developing ultra-low field pre-pulse
MRI (PMRI) systems. Fig. 10 shows the PMRI system with images acquired using a Bm field of 3.1 mT
(Larmor Frequency of 132 kHz), and an acquisition time of 6.5 min. Currently, the bore size of this system
and magnetic field gradient uniformity are inadequate for human brain imaging. This task will be led by
Neuberger at Penn State in close collaboration with the LANL team [38, 39]. Our effort will draw on our
existing PMRI infrastructure, where MRI imaging has already been demonstrated using SQUID and AM
[40, 41]. We will employ the room temperature, background field compensated, magnetometer arrays
developed as part of this research center to achieve two novel improvements to any ULF MRI: (i) internal
feedback control for regulation and shimming of gradient fields, and (ii) adaptive noise compensation for
improved SNR and image resolution. Interface electronics for the ultra-low field MRI system can
significantly differ from conventional electronics suitable for traditional MRIs and the effort to develop
them will be led by Sylvester. Among the main research challenges in designing the full ULF-MRI system
are sensitivity (and correspondingly, noise reduction schemes to detect the very small signals) and
maintaining low power consumption to ensure a highly portable system. This research will leverage our
past experience in low-power sensor interface electronics [42] though with focus on a new application space
of magnetic field detection [43]. We have previously developed a novel chopping approach that yielded the
best reported noise efficiency factor (NEF) among instrumentation amplifiers [44], which will be applied
in ULF-MRI, in noise-limited cases. As a result we will investigate its use in this emerging application
space. As the sensitivity of the background compensated MEMS magnetometers improve to fT range, we
will be able to realize a complete
room temperature and operational
ULF-MRI system capable of
diagnostic quality hydrocephalus
brain imaging within a few
minutes.
5. Workforce Development
A comprehensive workforce
development effort will be
undertaken as part of this ERC
ranging from K-12 to graduate and
career development as presented
in Fig. 11.
Advanced Technical and
Fig. 11: Overview of the Workforce Development Programs.
Professional Development:
Workshops on transferrable professional skills will be based upon the MBRAIIS teams experience in
offering professional development work-shops, and the literature on collaboration [45], communication
9
[46], inter-cultural interactions [47], ethics [48], lifelong learning [49], and the creative process in
engineering [50]. The technical breadth and transferable professional skills will prepare all students to
overcome the challenges to effective collaboration across disciplinary and cultural boundaries including the
need to develop common mental models for complex projects [51] and to deal with issues of trust [52] and
conflict [53]. In addition, graduate students will receive mentoring based on best practices identified in the
literature [54] including providing opportunities for the students to engage with role models among and
ensuring that the students receive extensive career counseling. Graduate students will find a rich and
inclusive environment with a clear context and metrics for their projects in the scope of the ERC program
defined from the outset. This will provide the students with unambiguous technical goals and
simultaneously allow them to contribute to other aspects of the program. Specific curricular impact will be
achieved through programs such as the MS in Neural Engineering where new graduate level courses such
as: introduction to neurons and brain, biological electrodynamics, physics of biomagnetism, magnetic
resonance imaging, designing sensors for implantation, adaptive field
compensation techniques, mathematical techniques for source localization will
be developed. We will leverage the industrial partners and advisory board
members to create REU programs, capstone projects and internship opportunities
for undergraduate students. In addition, graduate students will be afforded the
opportunity to work in the laboratories of international collaborators of the
MBRAIIS team, located in Europe and Africa. A new program on creative
expressions and Hands on Activities will focus on developing demos and art
exhibits for MBRAIIS Engineering for museums.
Support for Middle & High-School STEM Teachers: Professional development
opportunities for middle and high school teachers will be offered by all partner
Fig. 12: EEG activities at institutions, structured around the Framework for K-12 Science Education [55].
Science-Us Nittany Lion These teachers will work side-by-side with teams composed of graduate and
MD, Artificial Intelligence undergraduate students and ERC leaders in workshops and through
Science Camps. REU/RET/REHS programs to translate cutting-edge ERC science into activities
that align to key elements of the New Framework for Science Education including: Physical Sciences
(Forces and Interactions, Waves and their applications in technologies for information transfer): Life
Sciences (Information Processing); and Scientific and Engineering Practices (Systems thinking, modeling,
and engineering design). Collaborations with companies supporting K-12 learning technologies will
facilitate integration of these concepts into classroom via kits for inquiry-based activities facilitating the
understanding of medical technologies such as EEG and MRI. The Director of Diversity will work with
these teams to ensure that the messages are consistent with the recommendations from Changing the
Conversation [56], the Framework for K-12 Science Education, and advance the visibility of diverse role
models. Existing infrastructure such as the Penn State Center for Science and the Schools and Science-U
camps (Fig. 12) will afford opportunities to pilot such activities for young scientists of diverse backgrounds.
Recruit and Retain Diverse Students into STEM: The MBRAIIS Workforce Development team will build
on existing strategies at Penn State and partner institutions to attract students from underrepresented groups.
UG and GRAD level programs will be created and enhanced through relationships with Tuskegee
University (HBCU, minority-serving institution) and Gallaudet University (Deaf/Hard of Hearing). We will
leverage ongoing relationships with universities and secondary school systems (e.g., Steelton and Reading,
PA), at all partner institutions, that have high numbers of students from underrepresented groups. A critical
retention element for underrepresented students is a climate of inclusion. Activities for creating an inclusive
climate will be led by the Directors of Diversity and Workforce Development, include interactive
workshops for all faculty and students in the ERC based on best practices in the literature [57], and develop
sensitivity to challenges related to diversity in the workplace [58] as well as the skills needed to maximize
the potential of a diverse team.
Assessment of the Workforce Development Activities: Formative and summative data will be collected
with support from the Penn State Schreyer Institute for Teaching Excellence. The Director of Workforce
1
0
Development, Tom Litzinger (> 20 years of experience in conducting engineering education research), will
coordinate external assessment with Sage-Fox Consulting Group. He will coordinate the internal/external
assessments and work with the Workforce Development Advisory Board to ensure that formative feedback
is used to continuously improve Workforce Development activities.
6. Innovation Ecosystem Development
Goals: (i) Commercialization of specific
systems through transfer of technology to
industry, (ii) Innovation culture inclusive of
all ERC participants, and (iii) Environment
for cultivation of start-ups. Fig. 13 provides an
overview of the innovation ecosystem.
Commercialization - Industry Engagement
and Transfer: We have established
relationships in the sensors, biomedical, and
healthcare industrial sectors. MBRAIIS will
have an Industrial/Practitioner Advisory
Board (IPAB) as shown in Fig. 13(inset) in
Fig. 13: Overview of the Innovation Ecosystem configuration and
blue circles. The board will monitor the resources for MBRAIIS.
progress of various activities, evaluate the
commercialization potential of various engineered systems, technology readiness for translation, and advice
on appropriate course of actions through detailed technical reviews and recommendations. Developed
systems will be primed for technology transfer from the start through interactions with regulatory (FDA)
personnel to guide design requirements for technology acceptance. Industry members of the IPAB will have
direct access into the research and our students. The Penn State Office of Technology Management will
coordinate among partner institutions, the intellectual property policies/procedures in industry engagement.
Innovation Culture: We will implement a culture of innovation and entrepreneurial spirit designed to
create and promote enthusiasm for commercialization activity. Innovation workshops and interactive
programs (MBRAIIS Innovation Programs in Fig. 13) with entrepreneurs will expose MBRAIIS students
to the basics of The Business Model Canvas. All ERC participants will have an opportunity to explore the
translational potential of the technology being developed in their group. Students and Post-docs wanting to
advance their engineered systems through the innovation chain will be encouraged to participate in the more
formal 7 week Michigan NSF-ICORPS customer discovery program. Consequently, students will learn to
identify the value proposition and customer channels for their products and learn about IP creation and
protection, which are critical start-up components. We will leverage the infrastructure at each of our partner
universities to translate the pedagogy across the team.
Commercializing Technologies and Forming Start-ups: Penn State and the MBRAIIS partner
institutions have tested entrepreneurial infrastructure that is prime for encouraging and supporting start-up
activity. Select examples include: (i) Ben Franklin Technology Partners of Central PA technology funding
and business support services aimed at creating synergy among business, industry, and higher education;
(ii) Small Business Development Center - provides entrepreneurs with the education, information, and tools
necessary to build successful businesses in collaboration with faculty who offer SBDC clients the
opportunity to participate in classroom projects, student group projects, and special team projects; (iii)
Invent Penn State an institutionalized initiative underpinning the drive for job creation, economic
development and student career success by bringing discoveries to the marketplace; and (iv) Michigan
TechArb a student incubator at the University of Michigan Center for Entrepreneurship and the Zell Lurie
Institute for Entrepreneurial Studies. This infrastructure will be use to both foster start-up activity and create
cross-program collaboration among the partners to support entrepreneurship of students and faculty. Cross-
institution collaboration and training will be organized by a committee of leading principals from these
entrepreneurial programs at the project kickoff and executed during dedicated innovation session at the
MBRAIIS annual meetings.
1
1
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Resonator for Ultra-Sensitive DC Magnetic Field Detection," Scientific Reports, vol. 3, p. 1985,
2013.
[18] G. Hatipoglu and S. Tadigadapa, "Experimental studies in magnetically induced transverse force-
frequency effect in thin quartz microresonators," Journal of Applied Physics, vol. 118, p. 034508,
2015.
[19] G. Hatipoglu and S. Tadigadapa, "Micromachined Magnetoflexoelastic Resonator based
Magnetometer," Applied Physics Letters, vol. Submitted (in Review), 2015.
1
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[23] M. B. Pisani, Ren, K., Kao, P., and Tadigadapa, S., "Application of micromachined Y-cut quartz
bulk acoustic wave resonator for infrared sensing," Journal of Microelectromechanical Systems,
vol. 20, pp. 288 - 296, 2011.
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[33] J. iburkus, J. R. Cressman, and S. J. Schiff, "Seizures as imbalanced up states: excitatory and
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3
Srinivas Tadigadapa
Professor of Electrical Engineering and Biomedical Engineering
Penn State University, University Park, PA 16802.
Tel. (814) 865 2730, Fax. (814) 865 7065, e-mail: sat10@psu.edu
Professional Preparation
University of Delhi, India India B.Sc. Physics Honors 1986

Indian Institute of Technology India M.Sc. Physics 1988
Cambridge University UK Ph.D. 1994
University of Karlsruhe Germany Alexander von Humboldt Fellow 1993
Cambridge University UK Microelectronics Research Centre 1994 95
Postdoctoral Fellowship
Appointments
06/2010-Present The Pennsylvania State University Professor of Electrical Engineering and

Bioengineering
09/2007 03/2008 Tyndall National Institute Visiting Professor
06/2007 08/2007 University of Magdeburg Visiting Professor
08/2000 05/2010 The Pennsylvania State University Associate Professor of Electrical
Engineering
08/1996 07/2000 Integrated Sensing Systems Inc. Vice President
01/1996 06/1996 National Microelectronics Research Staff Research Scientist
Centre
Products
Five Closely Related Products
Gokhan Hatipoglu, and Srinivas Tadigadapa, Experimental Studies in Magnetically Induced
Transverse Force-Frequency Effect in Thin Quartz Microresonators, Journal of Applied Physics,
034508, Available Online, 2015. http://dx.doi.org/10.1063/1.4926802
Feng Li, Misra R., Fang Z., Wu Y., Schiffer, P., Zhang Q., Tadigadapa S., and Datta, S.,
Magnetoelectric Flexural Gate Transistor With Nanotesla Sensitivity, Journal of
Microelectromechanical Systems, 22(1), 71-79, 2013.
Chenchen Zhang, Gokhan Hatipoglu, and Srinivas Tadigadapa, High Speed, Ultra Smooth Etching of
Fused Silica Substrates in SF6, NF3, and H2O based Inductively Coupled Plasma Process, Journal of
Microelectromechanical Systems, 24(4), 922 -930, 2015.
David Gaddes, Rebecca Westford, Frank Dorman, and Srinivas Tadigadapa, Improved
micromachined column design and fluidic interconnects for programmed high temperature gas
chromatography separation, Journal of Chromatography A, 1349, 96-104, 2014.
Srinivas Tadigadapa and Kiron Mateti, Piezoelectric MEMS sensors: state-of-the-art and
perspectives, Measurement Science and Technology, 20(10), 1-30, 2009.
Five Other Products
David Gaddes, Melik Demirel, W. Brian Reeves, and Srinivas Tadigadapa, Remote Calorimetric
Detection of Urea via Flow Injection Analysis, Accepted and Available Advanced Article, Analyst,
2015.
2 1

Mateti K., Zhang Z., Rahn C. D., Tadigadapa S., Fabrication and Characterization of Micromachined
Piezoelectric T-Beam Actuators, Journal of Microelectromechanical Systems, 22(1), 163 - 169, 2013.
Kao P., Allara D., Tadigadapa S. Study of Adsorption of Globular Proteins on Hydrophobic Surfaces,
IEEE Sensors Journal; 11(11), 2723 - 2731, 2011.
Marcelo B. Pisani, Kailiang Ren, Ping Kao, and Srinivas Tadigadapa, Application of Micromachined
Y-Cut Quartz Bulk Acoustic Wave Resonator for Infrared Sensing, Journal of
Microelectromechanical Systems, 20(1), 288-296, 2011.
Ping Kao, David Allara, and Srinivas Tadigadapa, Fabrication and Performance Characteristics of
High-Frequency Micromachined Bulk Acoustic Wave Quartz Resonator Arrays, Measurement
Science and Technology, 20(12), 9pp, 2009.
Synergistic Activities
Member: of the Penn State Nanofabrication Facility Executive Committee
Associate Editor: Journal of Microlithography, MEMS & MOEMS (JM3), Measurement Science
and Technology (Journal), and IEEE Sensors Journal
Guest Editor: IEEE Sensors Journal Special Issue Oct. 2014 Best Papers from Sensors 2013.
Member: Technical Program Committee, Solid State Sensors, Actuators, Microsystems Workshop,
Hilton Head Island, 2012, 2014, IEEE Sensors 2013 -2014, Transducers 2015.
Technical Program Chair: IEEE Sensors Conference 2015, Busan, Korea and IEEE Sensors
Conference 2016, Orlando, Florida.
1
Lawrence H. Pick, Ph.D.
Gallaudet University, Department of Psychology
HMB 4th Floor, 800 Florida Ave NE, Washington, DC 20002
Lawrence.pick@gallaudet.edu, 202-651-5540 V, 202-250-2931 VP
The University of Massachusetts Boston, MA Linguistics & Psychology; B.A. 1992
The Graduate School and University New York, NY Neuropsychology; Ph.D. 2002
Center of the City University of New
York
North Shore University Medical Manhasset, NY Postdoctoral Fellowship 2002-2004
Center, Department of Neurology &
Neuropsychology
Appointments
2013-present Gallaudet University Affiliate Faculty, Doctoral Program in Educational
Neuroscience
2014-present Gallaudet University Professor, Doctoral Program in Psychology, Department of
Psychology
2009-2013 Gallaudet University Associate Professor of Psychology, Doctoral Program in
Psychology, Department of Psychology
2002-2008 Queens College-CUNY Assistant Professor Lecturer, Department of Psychology
1995-2000 Cornell Medical Center- Clinical Associate, Comprehensive Epilepsy Center,
New York Hospital Department of Neurology and Neuroscience
Products
1. Pick, LH., Koo, D., & Garrido-Nag, K. (In press). Neurolinguistics: Cortex Imaging. In P.
2. Boudreault, G. Gertz, & J.G. Golson (Eds.), The Deaf Studies Encyclopedia. New York: SAGE
Publications, Inc.
3. Pick, LH. & Morere, D. (In press). Neuropsychology. In P. Boudreault, G. Gertz, & J.G. Golson
(Eds.), The Deaf Studies Encyclopedia. New York: SAGE Publications, Inc.
Five Other Products
1. Garrido-Nag, K., Strasser, A., Koo, D., & Pick, L. (2014, November). Phonological access in Deaf
undergraduate native American Sign Language users. Presented at the ASHA Annual Convention,
Orlando, FL.
2. Pick, L. & Pietz, T. (2014). Telepsychology & persons with disabilities: What psychologists should
know. Washington, DC: American Psychological Association. American Psychological Association,
Committee on Disability Issues in Psychology. (2011). Training students with disabilities in testing
and assessment.

2
3. Harden, CL., Lazar, LM., Pick, LH., Nikolov, B., Goldstein, MA., Carson, D., Ravdin, LD., Kocsis,
JH., and Labar, DR. (1999). A beneficial effect on mood in partial epilepsy patients treated with
gabapentin. Epilepsia, 40(8),1129-1134.
4. Nikolov, BG., Harden, CL., Pick, L., Hosain, SA., Goldstein, M., Ravdin, L., Pulver, M., and Labar,
DR. (1999). Mood and anxiety changes in epilepsy patients treated with 3 different antiseizure
interventions. Epilepsia, 40, 530.
5. Harden, CL., Lazar, LM., Pick, LH., Nikolov, B., Carson, D., and Labar, DL. (1998). Effect of
lamotrigine on mood in adult epilepsy patients. Neurology, 50(4), 102.
1) (Mentor from 2011-present) The Mentoring Programs (American Psychological Association and
the Division of Rehabilitation Psychology) for undergraduate and graduate students from diverse
backgrounds in the fields of neuropsychology and STEM. Additionally, our research team has
supported up to three undergraduate students per year from Gallaudet University and other
universities during the past four years. These students representing diverse backgrounds
participate in our neuroelectrophsyiology and neuropsychology labs as part of their CAPSTONE
projects and/or as summer interns. Several of these students completed small research projects
and presented their findings at national and international conferences.
2) (Member/Chair) The Committee on Disability Issues in Psychology (American Psychological
Association) has collaborated with the APA Womens Program Office on the Women with
Disabilities in STEM Education Research Agenda Development Project. A product of this
working relationship was our participation in the 2012 conference, Women with Disabilities in
STEM Education: Research Agenda Development Project.
3) (Member) Education Committee/DistanCE Program (National Academy of Neuropsychology
from 2010-2014). Co-developed and/or supported the development of online courses (15- to 30-
CE credits) in the areas of clinical neuroanatomy, psychopharmacology, and epilepsy. These
courses are intended for postdoctoral fellows, academics, and licensed medical and mental health
professionals.
4) (Member) Editorial Boards of the Journal of Deaf Studies and Deaf Education (2012-present)
and the Journal of the American Deafness and Rehabilitation Association (2009-present).
Ongoing ad hoc reviewer for journals highlighting the fields of neuropsychology, behavioral
neuroscience, and neuroimaging.
5) (Chair from 2012-2015) Council on Graduate Education at Gallaudet University. During this
period, the Council worked closely with the deans and University faculty to assist in the
development and approval of a new interdisciplinary doctoral degree in Educational
Neuroscience. This degree provides deaf, hard of hearing, and hearing students access to
graduate education in the areas of neuroscience, neuroimaging, and translational research as
applied to educational systems.
1
Steven J. Schiff
The Pennsylvania State University, University Park, PA 16802
Massachusetts Institute of Technology Cambridge, MA Biology S.B. 1977
Duke University School of Medicine Durham, NC Medicine M.D. 1980
Duke University School of Medicine Durham, NC General Surgery Internship 1981
Duke University School of Medicine Durham, NC Neurosurgical Residency 1982-1989
Duke University School of Medicine Durham, NC Physiology Ph.D. 1985
Children's Hospital of Philadelphia Durham, NC Pediatric Neurosurgery Fellowship 1989-1990

Appointments
2013- Neurological Devices Panel, Medical Devices Advisory Committee, FDA 7/28/2013-7/27/2017
2007- Director, Center for Neural Engineering, Penn State University
2006- Brush Chair Professor of Engineering, Penn State University
2006- Professor, Depts. Neurosurgery, Engineering Sciences and Mechanics, Penn State University
2006- Professor, Dept. Physics (Courtesy Appointment), Penn State University
2005-2006 Director, Center for Neural Dynamics, George Mason University (GMU)
1998- Adjunct Professor of Pharmacology, George Washington Univ. Sch. of Medicine (GWUSM),
Associate Director, Center for Neuroscience and Behavioral Medicine, Childrens Research
Institute, Children's National Medical Center (CNMC)
1998-2005 Chief, Laboratory of Neural Dynamics, Krasnow Institute, BMU
1998-2005 Krasnow Professor of Neurobiology, Krasnow Institute, GMU
1998-2006 Professor of Psychology, GMU (Tenured 1999)
1994-1998 Associate Prof. of Neurosurgery, Pediatrics, and Physiology, GWUSM
1993-1997 Co-Director, Epilepsy Surgery Program, CNMC
1990-1994 Assistant Prof. Neurosurgery and Pediatrics, GWUSM
Products
1. Schiff, SJ., 2012, Neural Control Engineering. MIT Press, Cambridge.
2. Mandell JG, Langelaan JW, Webb AG, Schiff SJ. Volumetric brain analysis in neurosurgery: Part
1. Particle filter segmentation of brain and cerebrospinal fluid growth dynamics from MRI and CT
images. Journal of Neurosurgery: Pediatrics, 15(2): 113-124, 2015. (Cover Article part 1 of 3)
3. Whalen AJ, Brennan SN, Sauer TD, Schiff SJ. Observability and Controllability of Nonlinear
Networks: The Role of Symmetry. Physical Review X 5, 011005 (2015).
4. Schiff, S.J., Sauer, T., Kumar, R. Weinstein, S.L., Neuronal Spatiotemporal Pattern
Discrimination: The Dynamical Evolution of Seizures. NeuroImage, 28: 1043 1055, 2005.
5. Gluckman, B. J., Nguyen, H., Weinstein, S. L., and Schiff, S. J., Adaptive Electric Field
Suppression of Epileptic Seizures, Journal of Neuroscience, 21: 590-600, 2001.
Five Other Products
6. Schiff SJ, Jerger K, Duong DH, Chang T, Spano ML, Ditto WL, 1994, Controlling Chaos in the
Brain, Nature 370: 615-20.
7. Schiff SJ, 2010, Towards Model Based Control of Parkinson's Disease. Philosophical Transactions
of the Royal Society A, 368:2269-2308.
8. Schiff, SJ, Huang, X, Wu, JY, 2007, Dynamical Evolution of Spatiotemporal Patterns in
Mammalian Middle Cortex, Physical Review Letters, 98, 178102.
9. Wei Y,Ullah G, Schiff SJ. Unification of Neuronal Spikes, Seizures, and Spreading Depression.
Journal of Neuroscience, 34:11733-11743, 2014.
2
10. Schiff, SJ, Sauer, T, Kalman Filter Control of a Model of Spatiotemporal Cortical Dynamics,
Journal of Neural Engineering, 5:1-8, 2008.
1. Editorial: Neural Computation, Associate Editor, 2015-; Journal of Neural Engineering, Editorial
Board, 2013-; Physical Review X, Editorial Board 2012-; Physical Review Letters, Divisional
Associate Editor (Biological Physics), 2006-2011 (2 terms), Journal of Computational Neuroscience,
Action Editor, 2006-; Physical Review E, Editorial Board, (2000-2005, 2 terms).
2. Workshops: Executive Committee, Neuroscience Emphasis Year 2012-13, Mathematical Biosciences
Institute, Ohio State University. Organizer, NIH sponsored conference on the Ethics of Neural
Prosthetics, Fall 2007, Penn State University. Co-Organizer, Workshop on Pattern Formation in
Physics and Biology, Institute for Theoretical Physics, Univ of California at Santa Barbara, 2003.
3. NIH Study Section service: Member IFCN8 1998-2002, Chair IFCN8 and COG 2002-2004, Chair
Conte Center Study Section NIMH 2005, Evaluator NIH Directors Pioneer Award 2007; CRCNS
panel 2013, Multiscale Modeling panel 2013, 2014(Chair).
4. Boards & Panels: US FDA Neurological Devices Panel, 2013-2017. Advisory Board CURE
Hydrocephalus 2014-, Executive Committee Alliance for Spina Bifida and Hydrocephalus (includes
CDC), 2014-, Organization of Computational Neuroscience Board of Directors 2005-2008
5. Sustainable health engineering projects in developing world: CT as a substitute for MRI in Epilepsy
(Woodward Grant 2007-9), The one Laptop per ICU Patient (funded by Penn State Huck-SSRI-CSI
Institutes 2008-2014). Temporary Ugandan Medical License 2008-14. Phase III clinical Trial in
Africa 2013- (NCT01936272); NIH Directors Pioneer Award 2015.
1
Nian X. Sun
Northeastern University
Huazhong University of Sci.&Tech. Wuhan, China B.Sc., Materials Science and 1993
Engineering
Huazhong University of Sci.&Tech. Wuhan, China BS Minor, Electrical Engineering 1993
Chinese Academy of Sciences Beijing, China M. Eng., Materials Science and 1996
Engineering
Stanford University Stanford, CA M. Sc., Electrical Engineering 2001
Stanford University Stanford, CA Ph. D., Materials Science and 2002
Engineering
Appointments
2014-present Northeastern University Professor, Department of Electrical and
Computer Engineering
2014-present Northeastern University Director, W.M. Keck Laboratory of
Integrated Ferroics (KLIF)
2013-2013 Massachusetts Institute of Technology Visiting Scientist, Research Laboratory of
Electronics, EECS Dept.
2009-2014 Northeastern University Associate Professor, Department of
Electrical and Computer Engineering
2009-present Winchester Technologies, LLC President and Founder
2004-2009 Northeastern University Assistant Professor, Department of
Electrical and Computer Engineering
2001-2004 IBM & Hitachi Global Storage Tech Scientist
1998-2001 Stanford University Research Assistant
1997-1998 Chinese Academy of Sciences Research Associate
1993-1996 Chinese Academy of Sciences Research Assistant
Products
1. Tianxiang Nan, Yu Hui, Matteo Rinaldi & Nian X. Sun, "Self-Biased 215MHz Magnetoelectric
NEMS Resonator for Ultra-Sensitive DC Magnetic Field Detection", Scientific Reports, 3, 1985
(2013). (DOI: 10.1038/srep01985)
2. Ming Liu, Ziyao Zhou, Tianxiang Nan, Brandon M. Howe, Gail J. Brown, and Nian X. Sun,
"Voltage tuning of ferromagnetic resonance with bistable magnetization switching in energy- efficient
magnetoelectric composites", Advanced Materials, 25, 1435 (2013). (DOI: 10.1002/adma.201203792).
3. M. Liu, J. Lou and N. X. Sun, "E-field control of exchange coupling and deterministic magnetization
switching in AFM/FM/FE multiferroic heterostructures", Advanced Functional Materials, 21, 2593
(2011). (DOI: 10.1002/adfm.201002485).
4. J. Lou, M. Liu, D. Reed, Y. Ren, and N. X. Sun, "Giant Electric Field Tuning of Magnetism in Novel
Multiferroic FeGaB/Lead Zinc Niobate Lead Titanate Heterostructures", Advanced Materials, 21, 4711
(2009). (DOI: 10.1002/adma.200901131).
5. M. Liu, O. Obi, J. Lou, Y. Chen, Z. Cai, S. Stoute, M. Espanol, M. Lew, X. Situ, K. S. Ziemer, V. G.
Harris, N. X. Sun, "Giant Electric Field Tuning of Magnetic Properties in Multiferroic
ferrite/ferroelectric Heterostructures", Advanced Functional Materials, 19, 1826 (2009).
2
(DOI: 10.1002/adfm.200801907).
Five Other Products

1. S. X. Wang, N. X. Sun, M. Yamaguchi & S. Yabukami, Sandwich films: Properties of a new soft
magnetic material, Nature, 407, 150, (2000). (DOI: 10.1038/35025142).
2. N.X. Sun and K. Lu, Grain size limit of polycrystalline materials, Physical Review B, 59, 5987
(1999). (DOI: http://dx.doi.org/10.1103/PhysRevB.59.5987)
3. N.X. Sun, K. Lu and Q. Jiang, Grain boundary enthalpy of nanocrystalline materials crystallized from
the amorphous state, Physical Review B, 56, 5885 (1997). (DOI: 10.1103/PhysRevB.56.5885).
4. N.X. Sun, H. Lu, and Y.C. Zhou, Explanation of the melting behaviour of embedded
particles; equilibrium melting point elevation and superheating, Philosophy MagazineLetters, 76,
105 (1997). (DOI: 10.1080/095008397179282).
5. N.X. Sun and K. Lu, Heat capacity comparison among the nanocrystalline, amorphous, andcoarse-
grained polycrystalline states in selenium, Physical Review B 54, 6058 (1996). (DOI:
http://dx.doi.org/10.1103/PhysRevB.54.6058)
1. Contributions to the Science of Learning: Magic of Magnetism Program with Museum of
Science: Working closely with Museum of Science, Boston to design and develop an
interactive Magic of Magnetism program for the Museum of Science (MoS) Boston, together
with the Cahners Computer Place at the MoS for educating the general public on the topics of
magnetism and how it is linked to everyday life. The Magic of Magnetism website developed
with my students for educating the general public on magnetism has received positive
feedback. http://www.northeastern.edu/sunlab/mom/magic_of_magnetism.html,
2. Mentoring: Mentor high school students and high school teachers through Northeastern
Universitys Young Scholar program in STEM and the Research Experience for Teachers (RET)
3. Service to Community: Program Committee Member for Intermag Conferences, 2007, 2009,
2011, 2012; Program Committee, Magnetism and Magnetic Materials (MMM) Conference, 2007;
Technical Committee, International Conference on Microwave Magnetics, Fort Collins, CO, 2008;
and Boston, MA 2010.; Symposium Organizer, MRS Spring 2009 Meeting; Symposium Organizer:
International Meeting on Ferroelectrics (IMF) and IEEE Int. Symp. Int. Ferroelectrics, 2009 and
2013. Local host and organizer for the 2014 International Workshop on Power Supply on Chip
(PwrSoC 2014)
4. Reviewer for Funding Agencies: Reviewer for NSF, ARO, DOE, AFOSR
5. Reviewer for Journals: Nature Communications, Advanced Materials, Scientific Reports, Applied
Physics Letter, Journal of Applied Physics, IEEE Transactions on Magnetics, IEEE Transactions on
Microwave Theory and Techniques, Philosophical Magazine Letters, Journal of American Ceramics
Society, Advanced Functional Materials
1
Dennis Sylvester
Department of Electrical Engineering and Computer Science
University of Michigan
2417B EECS Building, 1301 Beal Avenue, University of Michigan, Ann Arbor, MI 48109-2122
University of Michigan Ann Arbor, MI Electrical Engineering B.S. 1995
University of California Berkeley, CA Electrical Engineering M.S. 1997
University of California Berkeley, CA Electrical Engineering Ph.D. 1999
Appointments
2010-present University of Michigan Professor: Dept. of Electrical Engineering and
Computer Science
2013-2014 Nanyang Technological University Visiting Professor: Electrical and Electronic
Engineering Dept.
2005-2010 University of Michigan Associate Professor: Dept. of Electrical
Engineering and Computer Science
2000-2005 University of Michigan Assistant Professor: Dept. of Electrical
Engineering and Computer Science
1999-2000 Synopsys Senior R&D Engineer
Publications
G.K. Chen, S. Hanson, D. Blaauw, and D. Sylvester, Circuit design advances for wireless
sensing applications, Proceedings of the IEEE, pp. 1808-1827, December 2010.
Y. Lee, G. Kim, S. Bang, Y. Kim, I. Lee, P. Dutta, D. Sylvester, and D. Blaauw, A modular
1mm3 Die-Stacked Sensing Platform with Low Power I2C Inter-die Communication and Multi-
Modal Energy Harvesting, IEEE Journal of Solid-State Circuits, pp. 229 - 243, January 2013.
S. Hanson, M. Seok, Y-S. Lin, Z. Foo, D. Kim, Y. Lee, N. Liu, D. Sylvester, and D. Blaauw, A
low voltage processor for sensing applications with picowatt standby mode, IEEE Journal of
Solid-State Circuits, pp. 1145-1155, April 2009.
R.G. Dreslinski, M. Wieckowski, D. Blaauw, D. Sylvester, and T. Mudge, Near-threshold
voltage scaling for energy optimal systems, Proceedings of the IEEE, pp. 253-266, February
2010.
B. Zhai, S. Pant, L. Nazhandali, S. Hanson, J. Olson, A. Reeves, M. Minuth, R. Helfand, T.
Austin, D. Sylvester, and D. Blaauw, Energy efficient subthreshold processor design, IEEE
Transactions on VLSI Systems, pp. 1127-1137, August 2009.
Five Other Products
R. Brown, D. Blaauw, M.P. Flynn, and D. Sylvester, VLSI design curriculum, American
Society for Engineering Education Annual Conference, 2004.
M. Seok, G. Kim, D. Blaauw, and D. Sylvester, A portable 2-transistor picowatt temperature-
compensated voltage reference operating at 0.5V, IEEE Journal of Solid-State Circuits, pp.
2534-2545, October 2012.
2
S. Hanson, Z. Foo, D. Blaauw, and D. Sylvester, A 0.5V sub-microwatt CMOS image sensor
with pulse-width modulation read-out, IEEE Journal of Solid-State Circuits, pp. 759-767, April
2010.
S. Hanson, B. Zhai, K. Bernstein, D. Blaauw, A. Bryant, L. Chang, K. Das, W. Haensch, E.
Nowak, and D. Sylvester, Ultra low-voltage, minimum energy CMOS, IBM Journal of
Research and Development, pp. 469-490, July/September 2006.
D. Sylvester and K. Keutzer, Getting to the bottom of deep submicron, Proceedings of
International Conference on Computer-Aided Design, pp. 203-211, 1998.
1. Director, Michigan Integrated Circuits Laboratory, EECS department, U-Michigan.
2. I am the micropower circuits thrust leader in the Wireless Integrated Microsensing and Systems
Center, led by Director Yogesh Gianchandani.
3. Guest Editor, IEEE Transactions on Circuits and Systems-II special issue on energy autonomous
microsystems.
1
October 19, 2015
Dr. D. Keith Roper

Leader of the ERC Program
Division of Engineering Education and Centers
National Science Foundation
4201 Wilson Boulevard, Suite 585
Arlington, VA 22230
Dear Dr. Roper:
As Dean of the Penn State College of Engineering, I am writing to express my strong support for the
NSF Engineering Research Center for Magnetics for Brain Interfaces, Imaging, and Stimulation
(MBRAIIS), which is described in this preliminary proposal by Dr. Srinivas Tadigadapa and his team.
This proposal describes a center that is well-planned and organized to advance truly transformative,
translational research.
The Penn State College of Engineering offers the ERC an exceedingly strong infrastructure as one of
the largest schools of engineering in the United States. NSFs S&E Research Expenditure Rankings
placed Penn State 1st in Materials Engineering, 3rd in Mechanical Engineering and 4th in Electrical
Engineering. US News and World Report names us as one of the top twenty-five engineering schools for
both undergraduate and graduate education in the United States and the fifth best on-line graduate
engineering program. Penn State Engineering is fifteenth for industry-sponsored, business-related
research. Our research productivity is equally impressive. Academic Analytics ranks us 11th for number
of citations and awards among all engineering programs in the USA.
The MBRAIIS ERC represents a flagship initiative because it marries two fields of expertise in which
Penn State excels--Materials Science and Neuroengineering. Like the Penn State artificial heart initiative
that began in the 1980s, this ERC team builds upon the combined strengths of the Penn State Colleges
of Engineering and Medicine. As we now tackle an even more complicated organ, the brain, members
of this ERC team are positioned to leverage the facilities and resources available through two major
interdisciplinary Penn State Institutes. Dr. Tadigadapa is a member of the Materials Research Institute
developing MEMS, Magnetometers, and Packaging. Dr. Schiff is a practicing neurosurgeon at our
College of Medicine and member of the Huck Institutes for the Life Sciences who directs our Center for
Neural Engineering. As such, this represents a key initiative of the institutional strategic plan to foster
the convergence of biological, engineering, materials and physical science expertise to enable
transformational discoveries supporting human health.
Within the College of Engineering, MBRAIIS will meet our units strategic planning commitments
toward excellence in our education, research and service programs and innovation and creativity in
teaching and learning, research and discovery. Further, it will embody Innovative Engineering
Education and Advanced Manufacturing for Medical, Electronic, and Mechanical Sciences. By the

Dr. D. Keith Roper
Page 2
composition of its key personnel and nature of student engagement, it will reflect our commitment to
Creating a welcoming campus climate; recruitment and retention of a diverse student body; recruitment
and retention of a diverse workforce; and, development of a curriculum that fosters cultural
competencies.
In addition to the strengths that the MBRAIIS team pulls from Penn State, it will leverage equally strong
expertise from its partners:
x Gallaudet University Psychology, Neurophysiology, Neuroscience, Hearing

x Northeastern University ECE, Magnetics, Ferroelectrics, Sensing
x Tuskegee University Composites, Plastics
x University of Michigan EECS, Low Power Circuits, Interfaces, MEMS, Magnetoelastic
Materials, Packaging, Power Optimized Interface Circuits, Wireless
If funded, I will chair an MBRAIIS ERC council of engineering deans from these partner institutions.
We will meet twice annually in conjunction with the ERC management and evaluation meetings to set
ERC policies and procedures, ensure that the multi-institutional team implements an integrated strategy
for research, workforce development and innovation ecosystem among the institutional partners, and
address other ERC issues that may require a coordinated response from the deans.
If the Penn State College of Engineering is selected to submit a full proposal and is ultimately fund, it is
fully committed to supporting the MBRAIIS ERC team. I firmly believe we have the potential to lead a
truly transformative center.
Sincerely,
Amr Elnashai
Harold and Inge Marcus Dean
cc: Theresa Mayer

Srinivas Tadigadapa

Tadigadapa-Nsf Erc Proposal

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02 INFORMATION ABOUT PRINCIPAL INVESTIGATORS/PROJECT DIRECTORS(PI/PD) and

co-PRINCIPAL INVESTIGATORS/co-PROJECT DIRECTORS

Gender: Male Female

Ethnicity: (Choose one response) Hispanic or Latino Not Hispanic or Latino

Race: American Indian or Alaska Native

Disability Status: Hearing Impairment

WHY THIS INFORMATION IS BEING REQUESTED:

Gender: Male Female

Ethnicity: (Choose one response) Hispanic or Latino Not Hispanic or Latino

Race: American Indian or Alaska Native

Disability Status: Hearing Impairment

WHY THIS INFORMATION IS BEING REQUESTED:

Gender: Male Female

Ethnicity: (Choose one response) Hispanic or Latino Not Hispanic or Latino

Race: American Indian or Alaska Native

Disability Status: Hearing Impairment

WHY THIS INFORMATION IS BEING REQUESTED:

Gender: Male Female

Ethnicity: (Choose one response) Hispanic or Latino Not Hispanic or Latino

Race: American Indian or Alaska Native

Disability Status: Hearing Impairment

WHY THIS INFORMATION IS BEING REQUESTED:

Gender: Male Female

Ethnicity: (Choose one response) Hispanic or Latino Not Hispanic or Latino

Race: American Indian or Alaska Native

Disability Status: Hearing Impairment

WHY THIS INFORMATION IS BEING REQUESTED:

REVIEWERS NOT TO INCLUDE:

COVER SHEET FOR PROPOSAL TO THE NATIONAL SCIENCE FOUNDATION

NSF 15-589 10/23/15 NSF PROPOSAL NUMBER

EEC - ENGINEERING RESEARCH CENTERS

Lawrence Pick DPhil 2002 202-651-5497 lawrence.pick@gallaudet.edu

Certification Regarding Conflict of Interest

Drug Free Work Place Certification

Certification Regarding Lobbying

Certification for Contracts, Grants, Loans and Cooperative Agreements

Certification Regarding Nondiscrimination

Certification Regarding Flood Hazard Insurance

Certification Regarding Responsible Conduct of Research (RCR)

CERTIFICATION PAGE - CONTINUED

Certification Regarding Federal Tax Obligations

Certification Regarding Unpaid Federal Tax Liability

Certification Regarding Criminal Convictions

AUTHORIZED ORGANIZATIONAL REPRESENTATIVE SIGNATURE DATE

Total No. of Page No.*

Cover Sheet for Proposal to the National Science Foundation

Project Summary (not to exceed 1 page) 1

Project Description (Including Results from Prior 10

Biographical Sketches (Not to exceed 2 pages each) 10

Current and Pending Support 0

Facilities, Equipment and Other Resources 0

Special Information/Supplementary Documents 2

Appendix (List below. )

MAGNETICS FOR BRAIN INTERFACES, IMAGING AND STIMULATION (MBRAIIS)

THREE PLANE STRATEGIC PLANNING CHART

The confluence of emerging micro- and nanoscale 10 MHz

performance magnetic, electronic, and piezoelectric ULF-MRI

materials offer opportunities for room temperature magnetic 10 kH z

sensing technologies capable of recording magnetic signals 1 kH z

sustainable and cost-effective magnetics technology for 1 Hz Motor Prosthetics - Stimulation

3. Strategic Plans Sensor & Array Packaging 100 fT 10 fT

Organization and Teaming: Interface Electronics

Biocompatibility Studies and Regulatory