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CURRICULUM VITAE

Dr Aysha Habib Khan

Date of Birth: 08/06/1964


Work Address: Department of Pathology & Microbiology, Aga Khan University,
Stadium Road, P.O. Box 3500, Karachi 74800 Pakistan
Email: aysha.habib@aku.edu
Telephone: Home: (92)21-35347821
Office: (92)21-34861926/1927
Mobile: 0301-2648832

EDUCATION:
Fellow of College of Pathologist Pakistan (2010)
FCPS (Chemical Pathology), College of Physician & Surgeons, Pakistan (1999)
MBBS, Dow Medical College, Karachi University, Karachi, (1989)
HSC, St Josephs College, Karachi, Pakistan (1981)
SSC, Farhana Girls School, Karachi, Pakistan (1979)

RESEARCH INTERESTS
My research focus from 2005 onwards is on bone and mineral disorders. I use my own
original approach to develop primary research questions and future direction for leading the
research. Currently, I am working with many intra and inter departmental multidisciplinary
collaborative teams within AKU. This research has built its authenticity both nationally and
internationally as is evidenced by the awards received. I am hopeful that this research will
bring a strong impact on health outcomes of bone and mineral disorders in Pakistan in time to
come.

Prior to this I have researched in area of inborn errors of metabolism. Currently as I link
service initiatives with research and development in the Section of Chemical Pathology, I
would maintain my initial commitment and hope to expand the horizon of research in this
important area of metabolic medicine.

TRAINING
Clinical attachment at Institute of Medical Research (IMR) for training on profiling of
aminoacids and organic acids, Kuala Lumpur, Malaysia from 2nd -12th September 2012
Clinical attachment at Kings College Hospital in Clinical Biochemistry, NHS Trust,
London from 12th June 18th July 2007
Specialist Registrar, Chemical Pathology Royal Free Hospital, London, UK (Sep04-Dec
04)
Clinical Attachment, Kings College Hospital, NHS Trust, London, UK (Oct 03 Sep04)
Resident, Clinical Chemistry/Chemical Pathology, Aga Khan University, Karachi (1995-
1999)
Resident Pediatrics, Aga Khan University, Karachi (1994-1995)
Medical Officer, Imam Zainul Abedin Hospital, Karachi (1990-1994)
Internship in Pediatrics, Civil Hospital, Karachi (1989-1990)

POSITIONS
Assistant Professor, Department of Pathology & Microbiology, AKU (July 05-To
date)
Assistant Professor, Department of Medicine, AKU (July 08-To date)
Senior Instructor, Department of Pathology & Microbiology, AKU (Jan03-June05)
Instructor, Department of Pathology & Microbiology, AKU (Jan00-Dec03)

DISTINCTIONS (FOR ACADEMICS AND RESEARCH)


IOF Young Investigator Award: R990G polymorphism of calcium sensing receptor
(CaSR) gene is associated with parathyroid hormone and calcium levels in subjects with
vitamin D deficiency. At International Osteoporosis Foundation Regionals 3 rd Asia-
Pacific osteoporosis meeting, organized in partnership with the Malaysian Osteoporosis
Society (MOS) and the Osteoporosis Awareness Society of Kuala Lumpar (OASKL) that
will be held in Kuala Lumpur, Malaysia on December 13-16, 2012 at Kuala Lumpur
Convention Center (KLCC)

Best Oral Presentation: Determination of bone health status in community dwelling


females in Karachi, Pakistan at Pakistan Association of Pathologist meeting 2011.
IOF Young Investigator Award: Determination of bone health status in community
dwelling females in Karachi, Pakistan at International Osteoporosis Foundation Regionals
1st Middle East & Africa osteoporosis meeting in Dubai (October 19-22, 2011)
Best Poster: Long term bone health in male renal transplant patients. Clinical
Biochemistry, KingsCollegeHospital, London. Poster presentation in 3 rdinternational
symposium of Pakistan endocrine Society at Liaquat National Hospital on April 29 th-30th
at Karachi, Pakistan
Best Oral Presentation Mixed Array of mutations identified in 21 hydroxylase gene of
patients with congenital adrenal hyperplasiain 2ndbiennial conference of Pakistan Society
of Chemical Pathologist, AKU Karachi (Awarded Azhar gold medal for best paper
presentation)
Won Merit Scholarship in MedicalSchool:
o Third Position in 1st Professional M.B.B.S. Examination (Distinctions in
Physiology and Biochemistry)
o Sixth position in 2nd Professional M.B.B.S. Examination
o Twenty second position in 4th Professional M.B.B.S. Examination

Position holder (10th) in Board examination of Higher Secondary School Certificate


Examination
DISTINCTIONS (FOR TEACHING AND TRAINING)
Outstanding teachers award
Outstanding Teachers Award, 2009 at AKU
Overseas Development Award, from Association of Clinical Pathologists, UK (2007)
Charles Wallace Trust Scholarship, UK (2004)
Faculty Development Award, 2003 Metabolic Bone Disease, Kings College
Hospital, NHS Trust, London, UK

TEACHING EXPERIENCE

UNDERGRADUATE TEACHING

Leadership positions:
Chair endocrine and reproduction module (2011 todate)
Chair Year-II, undergraduate curriculum (2007 August 2011)

Membership:
Member of the sub-committee on review of content of undergraduate curriculum for
year I & II (2011)
Member, curriculum committee at Aga KhanUniversity (2007 2011)
Mentor and advisor in the mentorship programof UGME (2000 to date)
Founding member of the group for teaching of communication skills in UGME at
AKU (2000 to date)
Member of GIT and nutrition module committee (2009 2011)
Member of the foundinggroup for teaching of clinical skills to the year I &II medical
student (2000 2003)
Member Year I committee (2005 2007)
Member of the endocrine and genitourinary module (2006 2009)
Member question review committee.Ideveloped/modified MCQs and SEQ questions
in different module committees in the initial phase, now in use for testing the integrated
concepts across YI & YII (2000 2003)

Module Coordination:
GIT and metabolism (2002)
Endocrine and genitourinary (2006)

Module Facilitation:
Introductory
Musculoskeletal
Endocrinology &metabolism
GIT and nutrition

Teaching undergraduate medical student in the old curriculum, including interactive


large group session, holding clinic-pathological conferences (1996 -2000)
Teaching metabolic bone diseases to Phase 3 students (2000 2003)

Elective Medical Students:


A large number of AKU and other medical students from all over Pakistan do electives with
me ranging from 2 weeks to 8 weeks. Many of them also undertake research projects and
publish manuscript.

Examiner/Assessor Undergraduate Education


Exam coordinator MBBS Year IA (2005 2007)
Exam coordinator MBBS IB (2008)
Examiner of Pathology, for MBBS IA and IB examinations (2005to date)
Examiner of communication skills in MBBS IA & IB examination (2005 to date)
Internal examiner of Pathology for final year surgical exam (2006 -2007)

Other Activities:
Attend annual retreats organized by DED
Conducted and attended retreat for review of undergraduate curriculum (2010)
Question review and question making for undergraduate students
Developed question bank for YII
Pathology teaching in musculoskeletal and endocrine &reproduction modules

POST GRADUATE TEACHING

Administrative Assignments PGME


Director Chemical Pathology residency program, Department of Pathology &
Microbiology, AKU (2006 to date)
Member Departmental Residency Committee, Department of Pathology & Microbiology,
AKU (2006 to date)
CPSP supervisor of fellowship training program (FCPS) in Chemical Pathology, (2006
to date). Currently, I am supervising 3 residents and one of my candidates is appointed as
Instructor in the Department.
Assessor for theory scripts fellowship and membership examination, at College of
Physician & Surgeon, Pakistan (2007 to date)
Examiner, fellowship examination FCPS Part II (Chemical Pathology), at College of
Physician & Surgeon, Pakistan (2008 to date)
Paper Setter for FCPS and MCPS at College of Physicians and Surgeon, Pakistan (2010
to date)
Observer for FCPS Part II practical examination, at College of Physician & Surgeon,
Pakistan (2008)
Chief Resident, Department of Pathology & Microbiology, AKU (1998-1999)
Co-Chief Resident, Department of Pathology & Microbiology, AKU (1997-1997)
Member representative Anesthesia, Radiology & Pathology Group (RAP group), PGME
committee, AKU (1998-1999)

Examiner/Assessor
Assessment of MCPS and FCPS paper II theory exam at CPSP
Paper setter for FCPS and MCPS examinations at CPSP (2010to date)
Developed questions based on data interpretation for CPSP question bank (2010to
date)
Examiner of practical examination for FCPS part II by CPSP (2010 to date)

Other Activities
Clinical research discussions (2007to date)
Case discussion and interactive lectures for residents of FCPS program (2005 to date)
Supervisor of 4 Chemical Pathology residents for FCPS II (2006 to date)
Revised curriculum for FCPS chemical pathology residency training program for AKU
post graduate residency program
Organized theory and practical mock exams for FCPS candidates of AKUH
Organized FCPS practical exam for CPSP examination at AKUH (as an exam center)

ALLIED HEALTH PROFESSIONAL

2008 to date Member Allied Health Task Force Committee, AKU

Teaching and Training Medical Technologists


1996 to date
Teaching of trainee medical technologists in the one-year Clinical Laboratory
technologist training program at AKUH
Organize Medical Technologist Training teaching of technologists at the section of
Chemical Pathology (2000 to date)
Supervise technologist research projects in their presentation and publication of research
material
Review and supervise manuscript of medical technologist for Departmental newsletter
(LABRAD)

Nursing Students
Conducted lecture for M.Sc. N students at School of Nursing (2010)

Masters program in epidemiology and biostatistics


Facilitated as an expert in the workshop on non-communicable diseases on Evaluation of
biomarkers used in Oncology: Applicability in research(2011)
Teaching session in Nutrition course on Research experience on vitamin D in Pakistan
(2009-to date)
Participated in the research activities of students,two students have completed their
research projects with me.
Committee member on research proposal of student (Anna Zulfiqar E11002) of MSc Epi
Bio

INNOVATIONS IN EDUCATION

Undergraduate Teaching
Designing and development of question bank for Y-II
Implementation of table of specification for all examination for paper setting
Introduced the concept of disorder of sexual differentiation in endocrine and
reproduction module (2006)

Post Graduate Teaching


Developed end of year objectives for post graduate trainees of Chemical Pathology
Revised curriculum for FCPS chemical pathology residency training program at AKU
Developed tools of formal assessment and evaluation with record keeping
Developed a question bank for Chemical Pathology

Medical Technologist
Initiated and submitted the draft concept of developing curriculum for technologist
training program at Clinical Laboratory. The initial proposal is made as an assignment for
Advanced level course on curriculum development conducted by DED. The assignment
has been reviewed by DED. It is being submitted for departmental review.

SERVICE AND ACTIVITIES WITHIN / OUTSIDE OF THE AGA KHAN


UNIVERSITY

A) INNOVATIONS IN SERVICE / PROCESSES / PROCEDURES, SINCE LAST PROMOTION

Leading the group for sectional activities for College of American Pathologist
accreditation. Currently developing and reviewing all process/all procedures and policies
and all manuals in the Section for CAP accreditation (2012)
Developed a program for point of care testing (POCT) for implementation at the
institutional level (2012). Work is in process
Developed several screening panels for laboratory testing like bone health and
osteoporosis. These testing panels are now very popular and have significant contribution
in volume and revenue growth (2011)
Team member for Process Improvement in Section of Chemical Pathology by Total Lab
Automation
Developed Manual of provocative testing in Chemical Pathology
Developed a tool for methodology evaluation of two tests
Working in collaboration with Molecular Pathology for starting of new molecular tests

B) NEW SERVICES INTRODUCED

Initiating a clinical laboratory service for diaagnosis of inborn errors of metabolism (Nov.
2012)
Initiation of sub-specialty of metabolic bone and mineral diseases from Chemical
Pathology platform (2008)
Initiated new bone markers in section of chemical pathology like vitamin D, N
telopeptide of type I collagen, ionized calcium, tubular indices for phosphate
reabsorption. Currently working on other markers (2005-2008)
C) SERVICE ON COMMITTEES WITHIN AND EXTERNAL TO THE UNIVERSITY

A. University related:
Chair of Endocrine and reproduction module (2011 2012)
Member YII Committee (2011 to date)
Member sub-committee of YII for reviewing the content of PBL in YI & II (2011to date)
Member of curriculum committee (2007- 2011)
Chair of YII committee (2007 2011)
Member of YI committee (2005-2007)
Interview panel for admission of undergraduates (2010, 2012)
Member of search committee for Chair of Pathology & Microbiology (2009)

B. Department/Section related:
Acting section head in absence of section head
Member departmental committee on ethics (2012)
Member task force for CAP accreditation
Co chair question review committee ( 2012-to date)
Member departmental sub-committee on appraisal & promotion (2012- to date)
Member departmental sub-committee on education (2012-to date)
Member departmental sub-committee on research (2011-to date)

C. Other Administrative Assignments:


Interviewed faculty members, lab technologists and residents at AKU (2005 to date)
Working group on College of American Pathologist accreditation at Section
Member of group working on integration of molecular testing in different sections of
department
Editor LABRAD (2005 to date)
Assistant editor LABRAD (2000 2005)
Publication of laboratory updates (2000 2007)

PUBLICATIONS (BASED ON BACHELORS MASTERS OR PH.D. RESEARCH)

A. PEER REVIEWED - RESEARCH PAPERS


1. R Bhimji,AH Khan*, I Lashari S Sabir, Z Nazir, G Billoo. Profile of children with
congenital adrenal hyperplasia-A hospital study. JPMA 2004 Oct;54(10):509-12
2. M Azim, AH Khan*, Zahida Latif, J. A. Paul, M Khurshid. Chromosomal abnormalities
as a cause of recurrent abortions. J P.M.A. Volume 53, No. 3, March 2003, 117-119.

3. AH Khan*, M I Nasir and T Moatter. Characterization of pathogenic mutations in 21-


hydroxylase gene of Pakistani patients with congenital adrenal hyperplasia -A preliminary
report. J.P.M.A, Vol. 52, No. 7 7/7 July 2002.

4. AH Khan*, A Khan, F Ghani, M Khurshid. Low lead exposure and blood lead levels in
children: A Cross-sectional survey. Archives of environmental health. Nov/Dec 2001 [Vol.
56 (No. 6), 501-505.

5. AH Khan*,Z Khilji, M Azim, M Khurshid. Trisomy 9 mosacism: A case report. JPMA,


Vol 51, No. 3, March, 2001

6. AH Khan*, F Ghani, A Khan, A Khan, M Khurshid. Role of serum angiotensin


converting enzyme in sarcoidosis. J.P.M.A., Vol. 48, No. 5, May 1998:131-133.

B. LETTERS TO EDITOR
1. AH Khan*. Trisomy 16, cause of first trimester abortion. J.P.M.A, Vol. 51, No. 10, Oct,
2001.378-379

PUBLICATIONS (AS PRINCIPAL or CO-INVESTIGATOR POST-MOST


ADVANCED DEGREE)

A. PEER REVIEWED - RESEARCH PAPERS

INTERNATIONAL
1. Q Humayun, R Iqbal, I Azam, AR Siddiqui, AH Khan, N Ansari. Development and
validation of sunlight exposure measurement questionnaire (SEM-Q) for use in adult
population residing in Pakistan. BMC Public Health 2012, 12:421

2. FJ Dar, R Iqbal, F Ghani, I Siddiqui, AH Khan*. Bone health status of premenopausal


healthy adult females in Pakistani females. Archive of Osteoporosis. DOI:
10.1007/s11657-012-0085-0

3. AH Khan*, D Rohra, S Saghir, S Udani, R Wood, A Jabbar. No change in calcium


absorption in adult Pakistani population before and after vitamin D administration using
Strontium as surrogate. Osteoporosis International http://dx.doi.org/10.1007/s00198-012-
2007-9

4. L Jafri, AH Khan*, A Hussain, F Ghani, I Siddiqui. Automated reporting of estimated


glomerular filtration rate: A comparison of creatinine clearance, modification of diet in
renal disease and Cockcroft gault equations from Pakistan. British Journal of Medicine &
Medical Research, 1(4): 445-458, 2011

5. L Jafri, AH Khan*, AA Siddiqui, S Mushtaq, R Iqbal, F Ghani, I Siddiqui. Comparison


of high performance liquid chromatography, radioimmunoassay and electro
chemiluminescence immunoassay for quantification of serum 25 hydroxy vitamin D. Clin
Biochemistry. Jul;44 (10-11):864-8
6. AH Khan, M Aban, J Raza, N Haq, A Jabbar, T Moatter. Ethnic disparity in 21
hydroxylase gene mutations identified in Pakistan congenital adrenal hyperplasia patient.
BMC Endocrine Disorders, 2011, 11:5

7. A H Khan*, G Naureen, R Iqbal. Determination of bone health status in community


dwelling females in Karachi, Pakistan. Osteoporosis Int (2011) 22( Suppl 5):S689-696.

8. AH Khan*, D Rohra, S Saghir, S Udani, R Wood, A Jabbar. Response of a single mega


intramuscular dose of vitamin D on serum 25OHD and parathyroid hormone levels in
vitamin D deficient volunteers in Karachi Pakistan. Osteoporosis Int (2011) 22( Suppl
5):S697-751.

9. R Iqbal, L Jafri, A Haroon, AH Khan*. Is neighborhood level information associated


with serum vitamin D levels in individuals residing in Karachi, Pakistan? Osteoporosis
Int (2011) 22( Suppl 5):S697-751.

10. SK Udani, AH Khan, SA Qureshi, S Khan, F Ghani, N Kayani. Evaluation of bone


metabolism in breast cancer patients and its correlation with serum vitamin D levels.
Osteoporosis Int (2011) 22( Suppl 5):S697-751

11. S Mansoor, AH Khan, F Ghani, Z Fatimi, S Badruddin, S Mansoor, I Siddiqui, A Jabbar.


Prevalence and significance of Vitamin D deficiency and insufficiency among apparently
healthy adults. Clinical Biochemistry (2010); 4(18):1431-5.

12. D Saleheen, A Nazir, S Khanum, S R. Haider, Usman Ahmad, H Khalid, I Hussain, K


Shahid, AH Khan,PMFrossard. A Novel Haplotype in ABCA1 Gene Effects Plasma
HDL-C Concentration. Int J Cardiol. 2007 Jan 31; 115(1):7-13.

13. A Jabbar, Farooqi A, AH Khan, N Islam, Haque, J Akhter. Clinical Characteristics and
outcome of Diabetic Ketoacidosis in Pakistani adults with Type 2 Diabetes Mellitus.
Diabetic Medicine; 21, 920-923, 2004

IN PRESS:

14. AH Khan, R Iqbal, G Naureen, F Nasir, F Dar. Prevalence of vitamin D deficiency and
its correlates: Results of a community based study conducted in Karachi, Pakistan.
Archive of Osteoporosis

15. AH Khan, G Naureen, R Iqbal. High prevalence of obesity call for a priority action for
non-communicable disease crises in adult women: findings of a community based study
in Karachi, Pakistan. Submitted to Food & Nutrition Bulletin. August 2012

NATIONAL
16. AH Khan, L Jafri, MA Hussain, S Ishaq. Diagnostic utility of anti-citrullinated protein
antibody and its comparison with rheumatoid factor in rheumatoid arthiritis. JCPSP 2012,
Vol 22(11)
17. AH Khan*, D Rohra, S Saghir, S Udani, R Wood, A Jabbar. Response of a single mega
intramuscular dose of vitamin D on serum 25OHD and parathyroid hormone levels in
volunteers in Karachi, Pakistan. JCPSP 2012, Vol 22 (4):207-212

18. FJ Dar, AH Khan*, I Siddiqui, F Ghani. Pattern of drug of Abuse in chemical samples.
JCPSP 2010, Vol 20 (9): 608-611

19. R Iqbal, AH Khan*. Possible causes of vitamin D deficiency in Pakistani population


residing in Pakistan. JPMA. Vol. 60, No. 1, January 2010

20. AH Khan*, NU Haq, J Raza, A Jabbar, T Moatter. Classic virilizing congenital adrenal
hyperplasia presenting late: case series from Pakistan. JPMA: Vol. 59 No. 9, September
2009, 643-646.

21. L Jafri, R Iqbal, AH Khan*. Correlation study of vitamin D levels between reference
method (RIA) and the test method (chemiluminescence). JPMA, volume 60 No. 2
Supplement April, 2009 S-01 S-49.

22. L Zuberi, AH Khan, Abdul J. Vitamin D deficiency in ambulatory patients. JPMA: Vol
58 No.9: September 2008, 482 484.

23. AH Khan*, A Jabbar, N U Haq, R Sutton. Vitamin D deficiency osteomalacia: The


continuing challenge. JCPSP 2008, Vol 18(10): 664-666 (letter).

24. AH Khan*, A Jabbar, R Baig, NU Haq, R Sutton. Vitamin D deficiency osteomalacia:


The continuing challenge. Pak J Pathol 2008; 19 (4): 146 -148

25. AH Khan*, I Azam, I Siddiqui, N Kayani, M Khurshid. Work flow analysis: Audit of the
turnaround time in clinical chemistry in a tertiary care hospital. Pak Journal of Pathology
2008; 19(3): 89-92.

SUBMITTED:
26. I Saher, AH Khan*. Frequency and distribution of congenital adrenal hyperplasia among
different provinces of Pakistan. Submitted to JCPSP in March 2012

27. R Iqbal, H Ali, F Dar, M Bilgirami, G Bano, AH Khan. Validation of a food frequency
questionnaire (FFQ) for assessing macronutrient and calcium intake in adult, Pakistani
population. Submitted to JCPSP December 2011

28. R Iqbal, L Jafri, A Haroon, AH Khan*. Illuminating the dark side: Vitamin D status in ten
different localities of Karachi, Pakistan. Submitted to JCPSP September 2011

B. LETTERS TO EDITOR

1. AH Khan*, L Jafri. Ionized calcium cannot predict vitamin D deficiency. Ind J Clin
Biochem. (Oct-Dec 2011) 26(4): 428-429

2. AH Khan*. Treating vitamin D deficiency (VDD) can also play a role in fight against
chronic disease. JPMA Vol 60 No. 2, February 2010
3. AH Khan*, R Iqbal. Vitamin D deficiency in an ample sunlight country. JCPSP 2009,
Vol. 19 (5): 267-268 (editorial)

4. AH Khan*. Vitamin D deficiency: Are we still ignoring the evidence. JPMA: Vol 58
No.9: September 2008, 482 484 (letter).

C. BOOK CO-AUTHORED
Farhan Dar and Aysha Habib Khan. Assessment of bone turnover in adult females and
its association with vitamin D blood levels.LAP Lambert Academic Publishing
ISBN 978-3-8473-1686-2, paperback, 184 Pages

D. BOOK CHAPTER AUTHORED


Aysha Habib Khan. Chapter 24: Nephrolithiasis and interrelationship of vitamin D,
Parathyroid hormone and Calcium-An update. Urolithiasis: Basic Science and Clinical
Practice. Editors J.J. Talati; H.G. Tiselius; D.M. Albala; Z.YE. Tongji. Springer 2013

E. LIST OF ABSTRACTS AND PRESENTATIONS SINCE LAST PROMOTION ONLY


1. AH Khan, G Naureen, FJ Dar, R Iqbal. Determination of Bone Health Status with
Vitamin D Deficiency (VDD) in Community Dwelling Females in Karachi, Pakistan.
Department of Pathology and Microbiology/Clinical Laboratories Research Day; October
11, 2012

2. M Riaz, H Majid, AH Khan. Frequency of Secondary Hyperparathyroidism in Subjects


with Vitamin D Deficiency. Department of Pathology and Microbiology/Clinical
Laboratories Research Day; October 11, 2012

3. L Jafri, S Ishaq, A Hussain and AH Khan. Diagnostic Utility of AntiCitrullinated


Protein Antibody in Rheumatoid Arthritis and its Comparison with Rheumatoid Factor in
Patients from a Tertiary Care Hospital of Pakistan. Department of Pathology and
Microbiology/Clinical Laboratories Research Day; October 11, 2012

4. N Sherazi, R Iqbal, AH Khan. Relationship of Fibroblast Growth Factor 23 Levels with


Dietary Phosphate Intake and Fractional Excretion of Phosphate (FEPO4) in Healthy
Volunteers. Department of Pathology and Microbiology/Clinical Laboratories Research
Day; October 11, 2012

5. H Majid, AH Khan, T Moatter. R990G Polymorphism of Calcium Sensing Receptor


(CaSR) Gene is Associated with Parathyroid Hormone and Calcium Levels in Subjects
with Vitamin D Deficiency. Department of Pathology and Microbiology/Clinical
Laboratories Research Day; October 11, 2012

6. M Q Masood, G Naureen, AH Khan. Efficacy of Commercially Available Mega Doses of


Vitamin D3 to Achieve Optimum Vitamin D Levels: Preliminary Findings from Pakistan.
Department of Pathology and Microbiology/Clinical Laboratories Research Day; October
11, 2012

7. R Iqbal, F J Dar, M Bilgrami, G Bano, AH Khan. Validation of a Food Frequency


Questionnaire for Assessing Macronutrient and Calcium Intake in Adult Population
Residing in Karachi. Department of Pathology and Microbiology/Clinical Laboratories
Research Day; October 11, 2012
8. R Iqbal, G Naureen, AH Khan. High Prevalence of Osteopenia and Osteoporosis in an
Apparently Healthy, Adult Pakistani Population Residing in a Rural Community.
Department of Pathology and Microbiology/Clinical Laboratories Research Day; October
11, 2012

9. ST Naeem, AH Khan, I Siddiqui, F Ghani. Frequency of Parathyroid Hormone Disorders


in Patients Presenting at an Out-patient Clinic. Department of Pathology and
Microbiology/Clinical Laboratories Research Day; October 11, 2012

10. R Maher, L Jafri, AH Khan. A comparison of vitamin D status in critically ill patients
and apparently healthy individuals at the 35th Annual & 5th International Conference of
Pakistan Association of Pathologist (PAP) 2011, CPSP, Karachi

11. H Majid, AH Khan, Q Masood, F Ghani, I Siddiqui. Role of Homeostatic Model


Assessment-Insulin Resistance in assessing insulin resistance in polycystic ovarian
syndrome. at the 35th Annual & 5th International Conference of Pakistan Association of
Pathologist (PAP) 2011, CPSP, Karachi

12. G Naureen, AH Khan, F Dar, R Iqbal. Determination of bone health status in community
dwelling female in Karachi, Pakistan at 35th annual and 5thinternational conference of
Pakistan Association of Pathologist meeting at CPSP, December 2011. Awarded best oral
presentation

13. S Iqbal, F Ghani, R Qureshi, AH Khan, I Siddiqui, I Azam. Presence of thyroid


peroxidase antibody among apparently euthyroidpregnant women and risk of adverse
pregnancy outcomes at the 35th Annual & 5th International Conference of Pakistan
Association of Pathologist (PAP) 2011, CPSP, Karachi

14. L Jafri, K Waqar, S Hira, T Javed, AH Khan,I Siddiqui,F Ghani. Utility of B-type
natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) in chronic kidney
disease: a head to head comparison of two heart failure markers. (Awarded Best Oral
Presentation for 2011) at the 35thannual & 5thinternational conference of Pakistan
Association of Pathologist (PAP) 2011, CPSP, Karachi

15. S Iqbal, AH Khan, F Ghani, I Siddiqui. Frequency and distribution of congenital adrenal
hyperplasia in different regions of Pakistan. at the 35thannual & 5thinternational
conference of Pakistan Association of Pathologist (PAP) 2011, CPSP, Karachi

16. ST Naeem, AH Khan, I Siddiqui, F Ghani. Frequency of parathyroid hormone disorders


in patients presenting in medical clinic patients. at the 35th Annual & 5th International
Conference of Pakistan Association of Pathologist (PAP) 2011, CPSP, Karachi
17. AH Khan, G Naureen, R Iqbal. Determination of bone health status in community
dwelling female in Karachi, Pakistan. IOF Regionals 1st Middle East & Africa
Osteoporosis Meeting in Dubai (October 19-22, 2011) (IOF Young Investigator Award)

18. R Iqbal, L Jafri, A Haroon, AH Khan*. Is neighborhood level information associated


with serum vitamin D levels in individuals residing in Karachi, Pakistan? IOF Regionals
1st Middle East & Africa Osteoporosis Meeting in Dubai (October 19-22, 2011)

19. S K Udani, AH Khan, SA Qureshi, S Khan, F Ghani, N Kayani. Evaluation of bone


metabolism in breast cancer patients and its correlation with serum levels of vitamin D
(25OHD).IOF Regionals 1st Middle East & Africa Osteoporosis Meeting in Dubai
(October 19-22, 2011)

20. AH Khan, D Rohra, S Saghir, S Udani, R Wood, A Jabbar. Response of a single mega
intramuscular dose of vitamin D on serum 25OHD and parathyroid hormone levels in
vitamin D deficient volunteers in Karachi, Pakistan. IOF Regionals 1st Middle East &
Africa Osteoporosis Meeting in Dubai (October 19-22, 2011)

21. AH Khan, F Dar, R Iqbal, F Ghani, I Siddiqui. Assessing bone health in adult
premenopausal females in KarachiA preliminary report from Pakistan. 4thnational
conference of Pakistan Society of Chemical Pathologist (PSCP), Lahore, February 2011

22. L Jafri, AH Khan, I Siddiqui, F Ghani. Is reflex reporting of estimated glomerular


filtration rate premature? 4th national conference of Pakistan Society of Chemical
Pathologist (PSCP), Lahore, February 2011

23. L Jafri, AH Khan, MA Hussain, F Ghani, I Siddiqui, S Ishaq. Diagnostic accuracy of


rheumatoid factor and anticitrullinated protein antibody in rheumatoid arthritis.
4thnational conference of Pakistan Society of Chemical Pathologist (PSCP), Lahore,
February 2011

24. F Ghani, N Sherazi, I Siddiqui, AH Khan. Assessing frequency of food and


environmental allergens in patients having high total IgE levels. 4thnational conference of
Pakistan Society of Chemical Pathologist (PSCP), Lahore, February 2011

25. N Sherazi, AH Khan,I Siddiqui, F Ghani. Fibroblast growth factor 23 (FGF-23) levels in
healthy volunteers and its relationship with serum phosphate and tubular maximum for
phosphate reabsorption (TmP/GFR). 4thnational conference of Pakistan Society of
Chemical Pathologist (PSCP), Lahore, February 2011

26. R Iqbal, G Bano, M Bilgirami, F Dar, AH Khan*. Development and validation of a food
frequency questionnaire for assessing macronutrient and calcium in women residing in
Karachi. Poster presented at the ASBMR 2010 Annual meeting 15-19, at Metro
Convention Center, Toronto, Ontario, Canada
27. AH Khan, F Dar, R Iqbal, I Siddiqui, F Ghani. Assessing bone health in adult
premenopausal females in Karachi-A preliminary report from Pakistan. Poster presented
at the ASBMR 2010 annual meeting 15-19, at Metro Convention Center, Toronto,
Ontario, Canada

28. F Dar, AH Khan, R Iqbal, I Siddiqui, F Ghani. Assessment of bone turnover and its
association with vitamin D blood levels in adult female residing in Karachi.
1) Accepted for poster presentation in Focus 2009. The Association of Clinical
Biochemistry annual national meeting at Liverpool
2) Oral presentation at PAP Meeting at Abbottabad, 2008

29. L Jafri, AH Khan, R Iqbal, I Siddiqui, F Ghani. Correlation study of Vitamin D levels
between reference method (RIA) and test method (Chemiluminescence)
1) Oral presentation at PGME conference 2009, at AKU
2) Oral presentation at PAP meeting at Abbottabad, 2008.

30. R Iqbal, M Bilgirami, AH Khan, S Urooj, A Jabbar and D Rohra. Developing a food
frequency questionnaire for assessing dietary calcium intake in an adult population,
presented at Research Assembly 2008 at The Aga Khan University, Karachi, Pakistan.

31. S Mansoor, F Ghani, I Siddiqui, AH Khan. Determinants of serum {25(OH)D} status in


otherwise healthy females and males at PAP meeting at Abbottabad, 2008

32. S Iqbal, F Ghani, R Qureshi*, AH Khan, I Siddiqui. Frequency of thyroid peroxidase


antibody in pregnant women poster presentation. Abstract presented at the 32 th National
conference of Pakistan Association of Pathologist (PAP), Abbottabad, November 2008

33. S Mansoor, F Ghani,AH Khan, I Siddiqui. Determinants of serum 25(OH)D status in


otherwise healthy females and males. Abstract presented at the 32 thnational conference of
Pakistan Association of Pathologist (PAP), Abbottabad, November 2008

34. S Kanwal, F Ghani,AH Khan, I Siddiqui. Chemical composition of renal stone and its
relationship with age, sex and weight of the renal stones evaluated from 1999 to 2006 at
referral laboratory. Abstract presented at the 31stnational conference of Pakistan
Association of Pathologist (PAP) 2007, Peshawar

35. S Mansoor, F Ghani, AH Khan, I Siddiqui. Prenatal diagnosis of downs syndrome by


karyotyping through amniocentesis in triple screen positive cases. Abstract presented at
the 31stnational conference of Pakistan Association of Pathologist (PAP) 2007, Peshawar

36. R UL Hassan, AH Khan, M Aban, N UL Haq, J Raza, A Jabbar, T Moatter. Classic


virilizing congenital adrenal hyperplasia presenting late: Case series from Pakistan
1) Poster presentation at 2ndbiennial conference of Pakistan Society of Chemical
Pathologists, March 2007
2) Poster presentation at symposium of Baqai Medical College, Feb 2007

37. AH Khan, M Aban, R UL Hassan N UL Haq, J Raza, A Jabbar, T Moatter. Mixed array
of mutations identified in 21 hydroxylase gene of patients with congenital adrenal
hyperplasia.
1) Association of Clinical Pathologist national scientific meeting 14 th -15th June 2007,
Church House, Westminster
2) Oral Presentation in 2ndbiennial conference of Pakistan Society of Chemical
Pathologist, AKU Karachi (Awarded Azhar gold medal for best paper
presentation)
3) Symposium of Baqai Medical College held at Baqai University, Karachi
4) Poster presentation in Pakistan Association of Pathologists meeting at Lahore 2006
5) 1stmultidisciplinary conference on human resource capacity building, East Africa, 4 th
-6th Sept

38. S Mansoor, AH Khan, F Ghani, Z Fatimi, S Badruddin, S Mansoor, I Siddiqui, A Jabbar.


Vitamin D status among healthy adults- a preliminary report from Pakistan.
1) Association of Clinical Pathologist national scientific meeting 14 th -15th June 2007,
Church House, Westminster
2) The Bone & Kidney, Oct. 12-15 2006, Copenhagen, Denmark.
3) Pakistan Association of Pathologist meeting at Lahore 2006

39. J Jabbar, I Siddiqui, F Ghani, F Riaz, AH Khan. Insulin tolerance test: cost
benefitsanalysis. Abstract presented at the 30 thnational conference of Pakistan Association
of Pathologist (PAP), Lahore, November 2006

40. AH Khan, M Aban, R UL Hassan N UL Haq, J Raza, A Jabbar, T Moatter. Genotype


phenotype correlation of patients with congenital adrenal hyperplasia and identification of
mutations in their 21 hydroxylase gene. (On behalf of the group). Research seminar on
reproductive health. Friday, September 15, 2006

41. LM Zuberi, AH Khan, S Arshad, M Islam and A Jabbar. Vitamin D deficiency in medical
clinic patients. Poster presentation in AKU research assembly on March 7- 8, 2006

42. AH Khan, S Mushtaq, Z Naqvi, A Siddiqui. High performance liquid chromatographic


method for determination of 25OHD. Departments of Pathology, Research Lab,
Biological and Biomedical Science, Aga Khan University. Poster presentation in AKU
research assembly on March 7- 8, 2006

F. OTHERS

DISSERTATION FOR FCPS


1. Aysha Habib Khan, Naila Kayani. Blood lead levels in children (1997)

2. Farhan J Dar, Aysha Habib Khan. Assessment of bone turnover in healthy adult females
and its association with vitamin D blood levels(2010)

3. Noreen Shirazi, Aysha Habib Khan. Fibroblast growth factor 23 levels in healthy
volunteers and correlation with serum phosphate and tubular maximum for phosphate
reabsorption (2012)

NEWSPAPER/NEWSLETTER ARTICLES
1. Report on 4th biennial course in Chemical Pathology for newsletter of International
Federation of Clinical Biochemistry (IFCC), 2012
2. Prevalence and causes of vitamin D deficiency in south Asian population residing in
different geographical areas. Dr Aysha Habib Khan, Ghazala Naureen, Dr. Romaina Iqbal.
APFCB newsletter (2012)
3. Report on Pakistan Society of Chemical Pathologist APFCB newsletter 2011
4. Bone health for life. Womens Own, April 2011
5. Growing interest in assessing vitamin D status and issues of vitamin D testing:
Experience from Pakistan. Newsletter of Asian Pacific Federation of Clinical Chemistry.
2010
6. Assessment of osteoporosis risk by NTx A biochemical marker. LABRAD, January
2010
7. N-telopeptide of type I collagen: A biochemical tool for assessing bone turnover.
LABRAD, January 2009
8. Vitamin D deficiency: Are we still ignoring the evidence. LABRAD, September 2008
9. Vitamin D measurement. LABRAD, September 2007.
10. Lab diagnosis of metabolic bone diseases. LABRAD, May 2007
11. Overseas development award. ACP National Scientific Meeting 14th -15th June 2007,
Church House, Westminster and attachment at Kings College Hospital, London 12 th June
-18th July, Aysha Habib Khan. Association of Clinical Pathologist newsletter, UK
September issue 2007
12. What causes Vitamin D deficiency? Physician Newsletter, AKUH
13. Vitamin D deficiency. Gulf Today, December 2006
14. The battle to conquer osteomalacia. DAWN, Health Page, 11th Dec 2002
15. CAH: defeating myths and dogmas. DAWN, Health Page, 10th July 2002

EDITORIAL ACTIVITIES- REVIEWER AND/OR EVALUATOR

REVIEWER OF JOURNAL ARTICLES:


Journal of Pakistan Medical Association
Annals of Karachi Medical & Dental College

REVIEWER OF GRANT PROPOSALS:


Higher Education Commission (HEC), Pakistan
University Research Council of Aga Khan University, Karachi Pakistan

EDITORIAL ACTIVITIES RELATED TO NEWSLETTER


1. Representative of the working group on newsletter of International federation of
clinical chemistry (IFCC)from Asia-Pacific Federation of Clinical Biochemistry and
Laboratory Medicine (2011-To date)
2. Member editorial team Asia-Pacific Federation of Clinical Biochemistry and
Laboratory Medicine(APFCB) newsletter (2009-To date)
3. Editor LABRAD: Quarterly publication of the Departments of Pathology & Radiology
and Clinical laboratories AKUH (Jan 2005 to date)
4. Assistant Editor LABRAD (2000 -2004)
5. Responsible for the publication of laboratory updates, for providing information about
tests/procedure to the physicians all over Pakistan since 2000 on new & old tests in
hematology, histopathology, microbiology, molecular pathology &chemical pathology.

GRANTS

INTRAMURAL FUNDING STREAMS:

URC:
1. Evaluation of bone health in Pakistani children with beta thalassemia major. Co-PI, URC
2012.Rs 17,00,000 only
2. Efficacy of 25 (OH) vitamin D supplementation and physical activity in improving
musculoskeletal health in individuals with chronic kidney disease (CKD). Investigator,
URC 2012 $22857 only. Work in progress
3. Determination of effective vitamin D replacement and monitoring strategies in vitamin D
deficient state (EVIREST). Co-PI, Seed Grant from URC 2011. PKR 9,23,863,Work in
progress
GRANTS CLOSED & PUBLICATIONS ACHIEVED

1. To assess the effect of dietary calcium intake and vitamin D status on bone turnover
markers in Pakistani adult females. PI, Awarded from Pakistan Science Foundation in
May 2010 December 2011, Rs 19, 844, 16 only

2. Determination of calcium absorption from intestine at various Vitamin D levels using


strontium as the surrogate marker. PI, Awarded from HEC in June 2009-Nov 2010, Rs
821,100 only
3. Genotype phenotype correlation and characterization of mutation in 21-hydroxylase gene
in patients with Congenital Adrenal Hyperplasia. PI, URC 2003-2007,US$ 15,000.

GRADUATE STUDENTS SUPERVISED

FOR FELLOWSHIP PROJECTS

1. Hafsa Majid; 2010 todate (Primary Supervisor); Polymorphism of CaSR gene and its
association in subjects with vitamin D deficiency. US $ 1000. 2011 resident seed grant
from Department of Pathology & Microbiology. Ongoing

2. Talha Naeem; 2009 todate (primary Supervisor); To determine the validity of bone
turnover markers in patients with osteoporosis and osteopenia presenting at a metabolic
bone clinic. US $ 1000. 2010 resident seed grant from Department of Pathology &
Microbiology. Ongoing
3. Noreen Shirazi; 2008-2012 (primary supervisor);. Fibroblast growth factor 23 levels in
healthy volunteers and correlation with serum phosphate and tubular maximum for
phosphate reabsorption. US $ 1050. 2009 resident seed grant from Department of
Pathology & Microbiology. Ongoing. Completed

4. Farhan Dar; 2007 2010 (primary Supervisor); Assessment of bone turnover and its
association with vitamin D blood levels in adult females.US$ 1000 from resident seed
grant, 2007 from Department of Pathology & Microbiology,US$ 3000 from URC of Aga
Khan University. Completed

5. Shireen Mansoor; (2005-2007) (secondary supervisor). Vitamin D status in a population


of healthy adults-A pilot study. URC US$ 3000 from Aga Khan University. Completed

FOR MASTERS PROJECTS

Anna Zulfiqar (E11002); 2010 todate; (Committee member) Association of dental caries with
passive smoking in 3-11 years old children of Karachi, Pakistan. Ongoing