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Lymphatic System

Spleen
•Capsulated
•Secondary
•Largest accumulation
of lymphoid tissue
•Very vascular
(macrophage removing
effete RBC)

Circulation in the Spleen

*Feline Spleen. The Schweigger-Seidel sheath is hard to find in reality.

Sheathed arterioles

Schweigger-Seidel sheath
(sleeve-like sheath)
Penicillary artery
(a.k.a. Brush arterioles)
Branching out

Follicular artery
Through follicle
Central artery

Spleen Spleen Labeled with doc  .

Spleen Spleen CA= central artery Labeled with doc  .

Spleen Labeled with doc  .

Spleen Collagen capsule Trabeculae Follicular (Central) artery Germinal Center Corona or mantle zone Lymph follicle B-cell outside ( Cortex) T-cell inside ( Medullary) .

Trabecular vessel Spleen Follicular (Central) artery Casule -> Trabeculae Trabecular vessel Vascular sinus (sinusoids) -Yung “spaces” especially at the margin -between red and white pulp .

RED PULP • Sinusoids=Space • Splenic Cords (Cord of Billroth) – Rich in macrophage and lymphocytes .

• Splenic Cords (Cord of Billroth) – Rich in macrophage and lymphocytes .

White Pulp • Lymphoid nodule • Periarteriolar lymphoid sheaths .

overlying the heart .Thymus •Capsulated •Primary •Bilobed •@ mediastinum.

Lobule Cortico. L-section . Septa medullary •Continuation junction of capsule •gives division to incomplete lobules C = Cortex M = Medulla CT = Connective tissue (Capsule) Thymus.

x-section . Lobules Cortex •stained blue-violet •high cell density Medulla •stained lighter and reddish •low cell density THYMUS.

MIGRATION OF THYMOCYTES medulla BONE ENTERS @ CORTICO. cortex Thymocytes/ Cortex maturing •stained blue-violet lymphocytes •high cell density Medulla thymocyte/ •stained lighter and reddish immature •low cell density lymphocytes Zoom. Zoom. x-section . MIGRATION TO MARROW MEDULLARY JUNCTION OUTER CORTEX THYMUS.

Zoom .Intralobular septa/Septa/ trabecula •Continuationn of the capsule •Divides the thymus into lobes.

Capsule Cortex Medulla •Outer region •Inner region Hassal’ body/ thymic corpuscle •seen in the medullary region Capsule .

Capsule Cortex Medulla •Outer region •Inner region capillary Hassal’s bodies -concentric layers of the reticulum cells Capsule - Zoom. medulla .

Hassal corpuscle/ Hassal’s bodies/ Thymic corpuscle Cortex Cortex • Formed by -higher cell density = darker concentric layers of reticulum cells • Stain intensely with eosin (pink) Medulla -lower cell Medulla density = lighter .

edu/histology/m/index. Credits to: http://www.htm Orange = thymocytes ( maturing lymphocytes) Red = mitotically active cells ( pyknotic nucleus= dark condensed chromatin) Green = Macrophage Purple = epithelioreticular cells .bu.

bu.edu/histology/m/index.htm .Credits to: http://www.

Credits to: http://www.htm Green = blood vessels ( capillaries) Red = epithelioreticular cells Orange = Hassal corpuscle .bu.edu/histology/m/index.

Blood vessels Credits to: http://www.bu.htm .edu/histology/m/index.

.Adulthood of Ye Thymus A = Adipose tissue L = Lymphoid tissue remnants CT = connective tissue. also where the capsule is.

Adipose Lymphoid tissue Medulla with Hassal’s corpuscle Residual Cortex tissue Adult Thymus showing fatty involution ( age involution) .

Adipose Residual thymus tissues Hassal’s body Adipose Adipose Hassal’s body Adipose .

Lymp Node •Encapsulated •Secondary .

.

Lymph Node in Theory Cortex B-cells predominate Lymphatic nodule Subcapsular sinus Germinal center Capsule Mantle zone Trabecula Medulla Efferent Medullary sinus lymphatic Medullary cord vessel T-cells predominate Paracortex Artery High endothelial venule Vein Afferent lymphatic Blood capillaries vessels around lymphatic nodule .

Paracortex •High-endothelial venules –Entry point of lymphocytes to the circulation .

Medulla •Medullary cords •Medullary sinus •Plasma cells •Lymphocytes Zoom .

Lymph Node .

Cortex Secondary follicle Medullary cord Medullary sinus paracortex Afferent Lymphatic vessels? Primary follicle Trabecular sinus/ cortical/marginal sinus Subcapsular sinus Lymph Node Primary Secondary follicle follicle .

.

.Tonsils •Partly Encapsulated •Secondary •Part of MALT •According to location: –Palatine –Pharyngeal –Lingual *See powerpoint notes for full name of MALT.

B-lymphocytes nasa loob Palatine Tonsils GC T-cell zone nasa interfollicular zone E LN C E LN LN LN GC E CT CT E E = Stratified Squamous Epithelium C LN = Lymphoid nodules GC = Germinal Centers CT = Connective Tissue Capsule C = Crypts .

 . Tonsils Infiltration of lymphocytes in the epithelium covering the crypts E Salivary corpuscles C Yung remnants na nasa crypts daw sabi ni Doc.

Palatine Tonsils CT E = Stratified GC Squamous Epithelium GC LN = Lymphoid C nodules C GC = Germinal Centers E LN CT = Connective Tissue Capsule C = Crypts E C LN .

Palatine Tonsils Follicle cap (B-lymphocyte cap) -ung nag surround sa nodule Epithelial covering Stratified squamous non- keratinized epithelium Capsular covering: Connective tissue Kaya siya partially encapsulated .

Lingual Tonsils Epithelium Crypts Lymphoreticular tissue part of Lamina propia Mucus glands of the Tongue Connective tissue capsule .

Lingual Tonsils Epithelium Crypts Lymphoreticular with the germinal centers Connective tissue capsule Mucos Glands Tongue Muscles .

Pharyngeal Tonsils multilayered ciliated epithelium Crypts Goblet cells Connective Tissue ( Blue) Lymphoreticular tissue (Lymphocytes and reticular fibers) .

Intestine •NOT Encapsulated •Secondary •Still with MALT •GALT (Gut-associated lymphoid tissue) .

GALT .

Peyer’s Patch (Plaques) Intestinal Villi Lymphoid Nodules Germinal Center .

Peyer’s Patches .

Peyer’s Patches .

efferents efferents in septa efferents present emptying into in trabeculae subcapsular sinus. with medulla. with medulla Patches (HEV). epithelial M cortex and central arterioles. Afferents at capsule. medullary many sinusoids cords and sinuses . Thymus MALT Lymph Nodes Spleen Cortex/medulla Distinctly present Absent Present Absent Lymphoid nodules Absent Present Present (in cortex Present (in white pulp only) only) Lymphatic vessels No afferents. few No afferents. efferent at hilum Unique features Hassall (thymic) Crypts lined by Thin paracortical Minor white pulp corpuscles in surface mucosa in region between component. No afferents. epithelialreticular cells in mucosa medulla. tonsils. with high major red pulp cells in cortex and over Peyer endothelial venules component.