Dermatologic

Dermatologic side effects have included Stevens-
Johnson syndrome and a lichenoid eruption. In
addition, isolated cases of unilateral aquagenic
wrinkling of the palms and papuloerythroderma have
been associated with aspirin therapy.[Ref]
Hepatic
Hepatic side effects have included hepatotoxicity and
cholestatic hepatitis.[Ref]
Oncologic
Oncologic side effects have included reports of
pancreatic cancer. Several epidemiologic studies
have suggested that chronic aspirin use may
decrease the risk of large bowel neoplasms.
However, other studies have not found such a
beneficial effect.[Ref]
Metabolic
Metabolic side effects have included dehydration and
hyperkalemia. Respiratory alkalosis and metabolic
acidosis, particularly during salicylate toxicity, have
been reported. A case of hypoglycemia has been
reported in a patient on hemodialysis. Salicylates
have also been reported to displace triiodothyronine
(T3) and thyroxine (T4) from protein binding sites.
The initial effect is an increase in serum free T4
concentrations.[Ref]
Cardiovascular
A 29-year-old female with a history of migraine
developed chest pain, tachycardia and orthopnea
following aspirin consumption at doses of 1500 mg
per day for several days. After discontinuation of
aspirin therapy, the patient's symptoms promptly
resolved. The patient consented to a pharmacological

oral tablet extended release. oral delayed release tablet. oral tablet disintegrating. and hypotension. oral tablet dispersible. rectal suppository Gastrointestinal Endoscopically identifiable gastric mucosal lesions occur in most patients who receive a single dose of aspirin. oral tablet. oral tablet chewable. oral delayed release capsule. oral capsule extended release. cranial hemorrhage. Some investigators have reported that modest doses may result in decreased frequency selectivity and may therefore impair hearing performance. ventricular ectopy.[Ref] Cardiovascular side effects have included salicylate- induced variant angina.[Ref] For Healthcare Professionals Applies to aspirin: compounding powder. headache. Tinnitus and subjective hearing loss (or both) may occur.[Ref] Nervous system Central nervous system side effects have included agitation. In addition. conduction abnormalities. oral gum. dizziness. Antiplatelet therapy has also been associated with acute deterioration of intracerebral hemorrhage. particularly during salicylate toxicity. at least one case of fluid retention simulating acute congestive heart failure has been reported during aspirin therapy. Clinically evident gastrointestinal bleeding . oral powder for reconstitution.challenge test which once again triggered the symptoms. cerebral edema. particularly in the setting of background noise. coma. confusion. lethargy and seizures.

ulcers) is low in rheumatic patients with no prior gastrointestinal symptoms who receive low-dose (less than 650 mg/day) aspirin therapy. More serious gastrointestinal effects include hemorrhage. and vomiting. heartburn. perforation. nausea. small bowel enteropathy. Anorectal ulceration and rectal stenosis have been reported in patients who abuse aspirin-containing rectal suppositories. endoscopically identifiable gastric mucosal lesions. nausea. abdominal discomfort or pain. and esophageal ulcerations.has been reported in as many as 3% of treated elderly patients.e. heart failure. cirrhosis). peptic ulcers.[Ref] Renal The mechanism of an aspirin-induced decrease in renal function may be related to inhibition of renal prostaglandin synthesis with consequent decreases in renal blood flow. The administration of high doses of NSAIDs to such patients has produced acute renal failure in rare instances. epigastric pain..[Ref] Renal side effects have included reduction in glomerular filtration rate (particularly in patients who are sodium restricted or who exhibit diminished . Vasodilating renal prostaglandins may be particularly important in patients who exhibit arterial underfilling (i. One case- controlled study has suggested that an association between aspirin (and other NSAID) consumption and appendicitis may exist. The risk of developing dyspeptic events (i.e.[Ref] Gastrointestinal side effects have included epigastric distress (in as many as 83% of patients treated with regular aspirin).

megaloblastic anemia. and nasal polyps). hematuria. In addition. and pancytopenia have been reported rarely. proteinuria. elevations in blood urea nitrogen. effective arterial blood volume. papillary necrosis. Approximately 10% to 30% of asthmatics are aspirin-sensitive (with the clinical triad of aspirin sensitivity. rhinitis. thrombocyturia. angioedema. conjunctivitis. and renal failure. thrombocytopenia. bronchial asthma. difficult . [Ref] Hypersensitivity The mechanism of aspirin-induced hypersensitivity may be related to an up-regulation of the 5- lipoxygenase pathway of arachidonic acid metabolism with a resulting increase in the products of 5-lipoxygenase (such as leukotrienes).[Ref] upper right abdominal or stomach • vomiting of blood or material that looks like coffee grounds • weakness or heaviness of the legs • weight gain yellow eyes and skin Aspirin side effects Get emergency medical help if you have signs of an allergic reaction to aspirin: hives.[Ref] Hypersensitivity side effects have included bronchospasm. elevations in serum creatinine. urticaria. and anaphylaxis.[Ref] Hematologic Hematologic side effects have included increased blood fibrinolytic activity. hypoprothrombinemia. such as patients with advanced heart failure or cirrhosis). interstitial nephritis. Aplastic anemia and eosinophilia have also been reported.

This is not a complete list of side effects and others may occur. tongue. See also: Side effects (in more detail) What other drugs will affect aspirin? Ask your doctor before using aspirin if you take an antidepressant such as citalopram. hallucinations. or pain lasting longer than 10 days. Stop using this medicine and call your doctor at once if you have: • ringing in your ears. rapid breathing. paroxetine. lips. or . breathing. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily. fluoxetine (Prozac). confusion. Coumadin. trazodone. swelling of your face. • drowsiness. Call your doctor for medical advice about side effects. fluvoxamine. Ask a doctor or pharmacist if it is safe for you to use aspirin if you are also using any of the following drugs: • a blood thinner (warfarin. seizure (convulsions). or vilazodone. or throat. You may report side effects to FDA at 1- 800-FDA-1088. heartburn. or • swelling. or stomach pain. • severe nausea. coughing up blood or vomit that looks like coffee grounds. • fever lasting longer than 3 days. sertraline (Zoloft). escitalopram. Common aspirin side effects may include: • upset stomach. or other medication used to prevent blood clots. or • mild headache. vomiting. Jantoven). • bloody or tarry stools.

Other drugs may interact with aspirin. and others. follow all dosing instructions provided with your medicine. If you are on a schedule. Pepto-Bismol. Pamprin Cramp Formula. The medicine may no longer be effective. Do not use extra medicine to make up the missed dose. Overdose symptoms may include temporary hearing loss.• other salicylates such as Nuprin Backache Caplet. and herbal products. Kaopectate. tell the surgeon ahead of time that you are using this medicine. including prescription and over-the- counter medicines. use the missed dose as soon as you remember. vitamins. This list is not complete. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Skip the missed dose if it is almost time for your next scheduled dose. Tricosal. KneeRelief. Do not take this medicine if you smell a strong vinegar odor in the bottle. What should I avoid while . Not all possible interactions are listed in this medication guide If you use the orally disintegrating tablet or the dispersible tablet. You may need to stop using it for a short time. See also: Dosage Information (in more detail) What happens if I miss a dose? Since aspirin is used when needed. seizure (convulsions). you may not be on a dosing schedule. Trilisate. Store at room temperature away from moisture and heat. or coma. If you need surgery.

Taking certain products together can cause you to get too much of this type of medication. Motrin. Ibuprofen may make this medicine less effective. and others. Motrin). Check the label to see if a medicine contains aspirin. Relafen. or pain medication. Indocin. Alcohol may increase your risk of stomach bleeding. Orudis. Lodine. allergy. tell your doctor if you have: • asthma or seasonal allergies. If you must use both medications. Voltaren. taking aspirin? Avoid drinking alcohol while you are taking aspirin. You should not use aspirin if you are allergic to it. ibuprofen. or if you have: • a recent history of stomach or intestinal bleeding. • stomach ulcers. take the ibuprofen at least 8 hours before or 30 minutes after you take the aspirin (non-enteric coated form). Many medicines available over the counter contain aspirin or an NSAID. If you are taking this medicine to prevent heart attack or stroke. or • if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID (non-steroidal anti-inflammatory drug) such as Advil. naproxen. Mobic. Aleve. • liver disease. • a bleeding disorder such as hemophilia. • gout. Feldene. • kidney disease. Ask a doctor or pharmacist before using any cold. avoid also taking ibuprofen (Advil. To make sure this medicine is safe for you. ketoprofen. or . • a bleeding or blood clotting disorder. or an NSAID. Toradol.

• heart disease. high blood pressure. or congestive heart failure. Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Ad closed by Stop seeing this adWhy this ad?   Ad covered content Seen this ad multiple times Not interested in this ad Ad was inappropriate We'll try not to show that ad again . You should not breast-feed while using this medicine. Tell your doctor if you are pregnant or plan to become pregnant. Aspirin can pass into breast milk and may harm a nursing baby.

Aspirin is used to treat pain. Take with food if aspirin upsets your stomach. Orudis. It works by reducing substances in the body that cause pain. It is sometimes used to treat or prevent heart attacks. Do not crush. or if you are allergic to an NSAID (non-steroidal anti-inflammatory drug) such as Advil. Swallow it whole. or open an enteric- coated or delayed-release pill. Important information You should not use aspirin if you have a bleeding disorder such as hemophilia. Indocin. Do not use in larger or smaller amounts or for longer than recommended. The chewable tablet form must be chewed before swallowing. What is aspirin? start 300 ad end 300 ad Aspirin is a salicylate (sa-LIS-il-ate). chew. and inflammation. and chest pain (angina). Ad closed by How should I take aspirin? Take aspirin exactly as directed on the label. or as prescribed by your doctor. Lodine. Aspirin should be used for cardiovascular conditions only under the supervision of a doctor. a recent history of stomach or intestinal bleeding. Aleve. and reduce fever or inflammation. Motrin. break. fever. strokes. .

and others. or chicken pox. Feldene. a serious and sometimes fatal condition in children. flu symptoms.Voltaren. SLIDESHOW Looking Ahead: Pharma Projections for 2016 . . Toradol.And Beyond Do not give this medication to a child or teenager with a fever. Salicylates can cause Reye's syndrome. Relafen. Mobic.