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Assessment of BIOPROTEIN-PLUS

Effectiveness of increasing CD4


concentration of HIV patients
(Infectious Dept. – National Hospital
of Pediatrics; Hanoi, Vietnam)
Principal Investigators
PhD., MD – Khu Thi Khanh Du; Director Neonatology
Master – Nguyen Van Lam & Associate

1. Objective

Decreased immune response of HIV/AIDS infected children is one of the


great challenges in treatment. To get the best results in HIV patient’s
treatment requires a combination of drugs and nutritional supplements.

This study is to demonstrate whether the use of BioProtein Plus (Biologically


Active Thymus Protein plus Zinc) will enhance and balance the immune
function in patients who have resistance to Antiretroviral (ARV) treatment.

2. Testers and Methodology

2.1 Testers: 30 patients, 9 months to 15 years old who have been


diagnosed HIV drug resistance (ARV) with CD4<20%.

Criteria in choosing patients:

Study Group: random, 30 patients under HIV drug resistance (ARV)


with CD4<20%, using BioProtein Plus (2 packets per day) for 1 month.

Control Group: random, 30 patients under HIV drug resistance (ARV)


with CD4<20%, not using BioProtein Plus.

Exclusion criteria:

No Corticosteroid use for 60 days prior to study.

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2.2 Methodology:

Clinically tested, comparison before and after treatment and control


group.

Procedure: Measure the CD4 concentration before and after using


BioProtein Plus for 1 month and compare to control group.
Dosage: 2 packets per day for one month.

3. Results

Table 1: Age of Study Group

Age Control Group Study Group P

< 1 year old 1 0


1-3 years old 2 4
> 3 years old 27 26
Total 30 30
Average Age 6.3+2.27 5.8+1.68 >0.05

Table 2: Accompanying Disease

Control Group Study Group P


Opportunistic Infection 3 4
No Opportunistic
Infection 27 26 P>0.05

Total 30 30

Table 3: HIV Treatment Guidelines


Control Group Study Group Total
Treatment Guideline 1 29 30 59
Treatment Guideline 2 1 0 1
P>0.05

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Table 4: Side Effects

Syndromes Control Group Study Group Total


Rash 0 0 0
Digestive disorders 0 1 1
Diarrhea 0 1 1
Others 0 0 0

Table 5: Comments of Users

Control Group Study Group Total


Easy to Take 30 30
Not Easy to Take 0 0

Table 6: CD4 Average Ratio

Control Group Study Group


Before Study 11.18+4.13 11.7+4.58
After Study 16.91+7.97 21.9+7.86
P<0.05

Comments: CD4 has clearly increased after using BioProtein Plus

Table 7: Average Weight

Weigtht Control Group Study Group


<0 kg 3 2
0 - 0.9 kg 8 9
> 1 kg 2 5
No Weight Gain 17 14
Total 30 30
P>0.05

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Table 8: Hb Average

Control Group Study Group


Before Study 11.78+1.31 10.04+2.87
After Study 11.62+0.86 10.71+1.44
P>0.05

Table 9: White Blood Cell

Control Group Study Group


Before Study 7940+344 7070+302
After Study 8520+270 7450+187
P>0.05

Table 10: SGOT

Control Group Study Group


Before Study 38.28+16.84 37.71+12.61
After Study 47.71+18.74 36.47+10.36
P>0.05

Table 11: SGPT

Control Group Study Group


Before Study 31.58+21.1 24.46+11.3
After Study 34+17.38 25.36+11.49
P>0.05

3. Discussion

The Study results on 30 HIV patients who are undergoing treatment for
HIV and experiencing ARV drug resistance at the Pediatric Hospital

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Infectious Disease Department from March to June 2009, using BioProtein
Plus as follows:

Clinically Reviewed

14 cases gained weight (46.7%) in which 5 cases (16.7%) gained


more than 1 kg.

No rash or allergic reaction during or after BioProtein Plus

100% reported ease of using

2 cases (6.6%) having digestive disorders while using BioProtein Plus.


However, each resolved within 3 – 5 days.

Increased CD4 cell counts: CD4 cell percentage increased from


11.7+4.58 to 21.9+7.86 (P <0.05).

Conclusion:

1. BioProtein Plus had the effect of increasing the quantity of CD4


cells (%) (P<0.05).
2. BioProtein Plus is safe, no side effects and is easy to use.

References:

Daniel Clark MD., BioProtein Plus - Biologically Active Thymus Protein


plus Zinc Balances Immune System Function. BioNutritional Formulas,
Melbourne FL.

Michael E, Rosenbaum MD., et al. Research Indicates Thymic Protein


Improves Immune Function in Chronic Fatigue Syndrome Patients.
Journal of Nutritional & Environmental Medicines (2001) 11, 241 –
247.

James L. Wilson Ph.D. Thymus Extracts: An international literature


review of clinical studies. Foundation for Immunology and Nutrition,
Development, Education and Research (1999).