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Rani and Rahman, IJPSR, 2017; Vol. 8(1): 17-28.

E-ISSN: 0975-8232; P-ISSN: 2320-5148

IJPSR (2017), Vol. 8, Issue 1 (Review Article)

Received on 02 March, 2016; received in revised form, 20 October, 2016; accepted, 21 November, 2016; published 01 January, 2017

Seema Rani *1 and Khaleequr Rahman 2
Department of Ilmul Saidla, Jamia Tibbia Deoband, Uttar Pradesh, India.
Department of Ilmul Saidla National Institute of Unani Medicine, Bangalore, Karnataka, India.
Keywords: ABSTRACT: Mimusops elengi L. is an Indian origin herb used in the
Molsari, Pharmacological, Unani and other traditional systems of medicine since long time. It is
Phytochemical, Unani commonly called by the names Spanish cherry, West Indian Medlar or
Correspondence to Author: Bullet wood tree. This plant is frequently cultivated throughout India
Dr. Seema Rani especially in north India for its ornamental appearance and fragrant
Assistant Professor, flowers. All parts of plant such as leaf, root, fruit, seed, bark, flower of
Department of Ilmul Saidla, Jamia Mimusops elengi were reported for treatment of various human ailments
Tibbia Deoband, G.T. Road, Uttar in traditional system of medicine. Pharmacological activities like
Pradesh, India. antimicrobial, antifungal, antioxidant and free radical scavenging, anti-
inflammatory analgesic, antipyretic, antiurolithiatic, cytotoxic, diuretic,
neuroprotective, anti-amnesic, cognitive enhancing, antihyperglycemic,
antihyperlipidemic, hypotensive, antiulcer, anthelmintic, antitumor,
wound healing, larvicidal activities have been scientifically evaluated for
various parts of this plant. A number of phytochemical constituents have
been identified in this plant that may be responsible for its
pharmacological activities. So many articles are available on Mimusops
elengi L., but from Unani literature the discussion is very limited. This
review is an effort to summarize the detailed prospects of ancient Unani
literature on Mimusops elengi L. along with modern researches. Further
studies should be done to make this drug world widely acceptable.
INTRODUCTION: Molsari (Mimusops elengi L.) This tree gives characteristic cool shade and
is a large glabrous evergreen Indian origin tree fragrant flowers. Leaves are dark green, pointed
attaining a height of 12-15 m distributed in and shiny. The tree bark is blackish. Small, white
peninsular region, western and eastern ghats and color, fragrant flowers grow on its branches. Its
cultivated in the plains e.g., tropical forests in south flowers are also known as bhara maranand as
Asia and in India. Plant is cultivated for its fragrance of flowers attracts bumble bees
ornamental appearance, elegant look, shade and for (bhanwara) toward it. Flowering time is from April
fragrant flowers.1 The Plant has vast description in to June every year and fruiting time is from May to
Unani literature as Molsari. It is described as large September. Fruit is round, smooth, shiny, 0.75 inch
tree like mauwah, kherni and cheeku. long and get yellowish after ripening. Fruit is sweet
QUICK RESPONSE CODE with slight bitterness in test. 2 It is also are
DOI: considered as a sacred plant among Hindus.
Mimusops elengi flowers as symbol of love and
beauty.3 M. elengi is used in the Unani and other
Article can be accessed online on: traditional systems of medicine since long time.
Medicinally various parts of M. elengi were
DOI link: (1).17-28 reported for treatment of several human ailments.4

International Journal of Pharmaceutical Sciences and Research 17

6. Vovoli. Calyx is 1 cm long. (alexipharmic). ring worm.6 its flowers. tube 1. Sanskrit:  Bark: Mubarrid (cooling). IJPSR. Seeds are solitary.5 mm long. nafe suzak Maulsari. in cold diseases and heart problems. fulvous pubescent. Madhugandha. 7 Cold and Dry 3o. yellow when ripe. dafe jiryaan. Chirapushpa. staminodes eight in number in renal and urinary bladder stones. 7. 7.3-2. 8 fissured with densely spreading crown. 100ml of water is used in paediatric dry cough. leaves. 95 Marathi: Bakhor. slightly longer than corolla. International Journal of Pharmaceutical Sciences and Research 18 . It is cultivated in South India and central beneficial in ejaculation problems. pyretic) muqawie qalb (cardiotonic). Owli. 2017. Gujarati: Babhuli. Flower: Hot and Dry. Berry  Decoction of four to five flowers infused in about 2. fruit and bark in 200gm wax is Parts Used: Stem. 5 diseases. Bakulah Bakulah.  Bark powder application on forehead cures Petioles and twigs produce a watery milky exudate. ovoid. qalb wa jigar. 5. and and 3 gm sugar in morning and evening is Australia.  Application of ointment prepared of 25 gm of Mewad Awadh forests and Andaman Islands. generally about 15 m high. Vavoli. 7 Kingdom: Plantae Order: Ericales Afaal (Functions): Family: Sapotaceae  Seeds: Qabiz (constipative). Its essence is used in palpitation and other heart compressed. muqawie meda (stomachic). headache.5 moderate to large size evergreen tree. Hindi: (astringent).8 Vernacular Names: Urdu: Molsari. Fruit: Cold and Dry 5. mumsik mani. Ovalli. Bullet-wood tree. Corolla  Gargles with decoction of bark are beneficial in white coloured. Keshu kesara. cardiac and liver tonic). 6 (antidiaphrotic) and dafae amraz balghmi wa safrawi (treats phlegmatic and bilious Botanical Description: Mimusops elengi is a diseases). Leaves are 6.5 cm long. qabiz cherry. 3 pieces of almond tropics including Malaysia. Kesha. style grooved. corolla longer throat pain. tiryaq Madhupushpa. 8(1): 17-28.Rani and Rahman. manae irq Wowl.4. Myanmar and Sri Lanka but cultivated across the  Taking 10 gm fresh flowers. Dawai Istemal (Therapeutic Uses): 5. flowers. Ovary silky pubescent. 4. slightly  Syrup prepared from ripen flowers is beneficial twisted. Barsoli. with wavy margins with petioles 1. P-ISSN: 2320-5148 Taxonomy: Temperament: Cold and Dry. and other skin and gum. glaborous. Vol.  Arq molsari prepared with its flowers is useful Habitat: Mimusops elengi is native in India. Bihar. Udumbara. irritation and stomatitis. 4 English: Spenish qatile kirme ama (anthelmintic). Stem is ash coloured dark. leucorrhoea). sweet in fragrance. brown and shining.3-10 cm long and 3. Botanical Name: Mimusops elengi 5  Flower: Muqawie dandan wa lissa (teeth and gums tonic). E-ISSN: 0975-8232. anthers glaborous. This alternate with the stamens. Indian medlar tree. acuminate. India especially in Madhya Pradesh. qate safra (antibilius). Singapore. fruit seed beneficial in boils. preparation dissolves and expels the stones. Species: Elengi muqawwi meda.8 Genus: Mimusops  Fruit with seed: Muqawie bah (aphrodisiac). lobes 8 mm long and  Inhalation of its flower powder is beneficial in are twenty four in numbers in two series. Varsoli. ovoid. nafe silanur rahem (cures Bolsari. Dhanvi.5. (stomach. filaments Headache.  Leaves: Habisuddam (haemostatic). dafe humma (anti- Anangaka. 6 diseases. Wovali. (cures gonorrhoea). Bolsari. short. Bakul. than calyx. contains a juicy pulp.2-5 cm broad pointed with  Bark decoction of molsari bark is used to serpentile ends or elliptic or obovate and leathery reduce the fevers. habis (astringent).5 cm long. Jammu. Bakula. bark.

23-tetrahydroxy-urs-12-ene and 1beta- 16α-hydroxy Mi-saponin A. octadecadienoic acid. lipid concentration of leaves was higher in summer Mazarrat (Adverse Effects): Naffakh (flatulent). taraxerol.13 molecules obtained from stem bark. β. cadinol. isolated a novel minor triterpenoid coloring matter and starch. dihydro quercetin. -sitosterol--d glucoside and qurecetin.5 to 16.).6β. Vol.7 mg/gm). mimusops acid and mimusopsic acid. carotene and lupeol. sodium salt of betulinic acid and saponins. glycoside. and spinasterol. alpha- FAB-MS of the mimusopsin isolated earlier from spinasterol glucoside.dihydroxyoleana . beta amyrin. while the fruit pulp is beneficial in obeta.7 babool ki chhaal aur phal (Bark and qurecitol.D . hexadecanoic acid. Miglycoside 1. hazime (digestive) 7 mg/gm) and winter (30. 12 farnan-2-one-3 betaol (mimusopfarnanol).. The structure of the hydroxy-3beta-hexanoyllup-20 (29)-ene-23. Sufoofe sailan. qurecitin. taumuurolol.7 mg/gm). wax. 12-dien-16-one and 3β. 8(1): 17-28. IJPSR. isolated six saponins Leaves heartwood and roots: Leaves contain from the seed kernel of Mimusops elengi.(1→3) – β . d-mannitol. 24 Badal (Substitute): Bhon phalli (Corchorus Seeds: The seed kernels yield 16-25% of a fatty oil depressus).).e. dihydroqurecitin. E-ISSN: 0975-8232. mi-saponin A 16 C NMR and LS-MS linked-scan. new gallic acid respectively. mimusopgenone and mimugenone en-3 beta-ol.(1→4) – quercetin. lupeol.10 The fat free seed meal yield 2.7 mg/gm) over that of monsoon (29. pentacyclic triterpenes 3beta. P-ISSN: 2320-5148  Enema made up of its seed relieves steroidal saponin. Leaves contain qurecitol. 6beta. anthraquinone glycoside and cardiac ursolic acid. lupeol.8 Musleh (Corrective): Shahad khalis (pure honey). 5 alpha-stigmast-9(11) en-3- constipation.d glycosides of beta sitosterol. -carotene.o-beta-dxylo dysentery. 12 – dien – 16 . phthalate.23-tetrahy Fruit and seed: Fruit and seed showed presence of droxyolean-12-en-28-oic acid 28-O-α-l-rhamno quercitol. 10 saponin mimusin {3-O-[β-d-glucopyranosyl- (1→6)-β-d glucopyranosyl]-2β. alpha trihydroxy-28-noroleana-5. isolated two new pentacyclic 3-one. 28- minor saponin was established by comparing its 1 3 dioic acid. monsoon medicines (har wa ratab advia) 7 (13. farnan- Suchetra Sen et al. fatty acid esters of alpha-spinasterol.(1→2) – α -l-arabino spinasterol.4% bassic acid (C30H46O5). 2017. 9 arabinose(2 mol. a characteristic Miqdare Khuraq (Dose): 9 gm -10 gm7 sapogenin of sapotaceae. furanoside was isolated from the roots of Mimusops  Eating five to six fruits daily also cures elengi. hentriacontane. known triterpenoid saponins. ESI-MS data with alpha-hydroxy mi-saponin A. mg/gm) summer (16. triterpene 3β-hydroxy-lup-20(29)-ene- from its seeds and characterized as 2β.Rani and Rahman. mimusopside the same source.8 mg/gm) show highest ghee (butter).11 Phytochemical Constituents: Preliminary phytochemical screening revealed the Stem bark: Taraxerone.5.75 8 qabiz (constipative).. fruit treats burning micturition. dysentery and diarrhoea.glucopyranosyl (1-5) . mimusops.l rhamnopyranosyl .7. and olean-18-en-2-one-3-ol and lup-20 (29)- triterpenes.) and glucose(1 mol. based on their spectroscopic esters.3β. betulinic acid presence of phyto constituents such as terpenoids. Mi-saponin A and 19alpha. A new International Journal of Pharmaceutical Sciences and Research 19 .23- 23. in addition to two mimugenone. ursolic acid.14 A and B In another study Lavaud et al. The tree also yields a gum. Eating of eight to nine hentriacontane. root of Acacia Arabica) 8 b sitisterol glycosides. Bark also contains tannins. ursolic acid. alpha α . -sitoserol. diisobutyl 23. 28-dioic acid.d-xylopyranosyl . pyranoside} from the seeds. (phenyl propyl gallate) are important properties. The bark of lipid concentration was ranging from 13.3β.. 8 use along with hot and wet content over other season i. taxifolin. (32. 11 The 7. pyranosyl .5mg/gm) and winter (14. Sahu et al. It also yields a saponin Mashhoor Murakkab (Famous Formulation): which on hydrolysis yields ramnose (2 mol.

lup-20(29)-en-3beta-ol pyranosyl (1 → 3)] α-l-rhamnopyranosyl(1 → 2) α.46. 3 rhamnopyranosyl(1 → 3) β-d-xylopyranosyl(1 → 4) α-l-rhamno pyranosyl (1 → 2) α-l-arabino Ethnobotanical Uses: 1. disease of nose.Rani and Rahman. Currently bark extract of M.D-gluco have antiulcer activity. stearic10.3. 19 Bhuyan and Saikai extracted dye from for odontopathy. 4.15  Its bark is used as a gargle for odontopathy.(2''.4. Bark is also used the bio-marker quercetin. strengthening the gum and enter into the hydroxybenzenemethanol and cinnamyl alcohol composition of various herbal tooth powders. stigmasterol – 3 – o – β – d . 2'-(1'''-geranyloxy) – beta .4. in layer chromatography method for detection and biliousness as an anthelmintic. 27 pyranosyl) protobassic acid. >1'') . whereas under the name of “Vajradanti”.10. 22 Fresh flowers on glucuronopyranosly) 28-O-(α-l-rhamnopyranosyl water distillation yield 0.49%. Vol. hydroxy benzoate (5). 5 –tri smoked in asthma. oil is as follows: palmitic. high performance thin to cure diseases of gums and teeth. farnan-2-one-3β-ol helps to fix loose teeth. 4-hydroxy hydroxyprotobassic acid and 3-O-(β-d-gluco benzaldehyde. expectorant. 3-O-(β-d. compounds namely oleanolic acid. isolated a new gums. 20 Akhtar et al.4'' . (mimusopfarnanol). IJPSR.beta-D-glucopyranosyl 3. as a gargle dioic acid. 0.37 and 4. 2017. also islated and characterised.5-trihydroxy benzoate (4). beta-D-glucopyranosyl-(6'-->1'')-beta. beta-D-glucopyranosyl (6'-- wounds and ulcers. stomachic and quantification of quercetin in Mimusops elengi cardiotonic.14.21 New gallic acid esters phenyl cardio tonic and to treat mouth ulcer.. 4. elengi leaves was developed. olean-18-en-2-one-3-ol. propanoxyl gallate (1). oleic 63.  Bark is used as an astringent and applied behenic. Oil: The composition of the total fatty acids of the diarrhoea and dysentery.  The flowers are used for preparing lotion for >1'')-beta-D-rhamnosyl 3. from the seeds of Mimusops elengi Linn. inflammation and bleeding of Mimusops elengi.16 externally too. 8. about 10. 5 . Unripe fruit is used as a masticatory and farnane-type triterpenoid. 10. beta-D-glucopyranosyl (6'--  Internally bark skin is benevolent in >1'')-beta-D-glucopyranosyl .18 Jahan et al. 5.  The flowers are considered expectorant and D-glucopyranosyl-4''-(4'''-n-butylphenyl) 3. Mimusops elengi . 26.49. pyranosyl (6'-->1'')-beta-D-glucopyranosyl-4''-  Flowers are used for preparing a lotion for phenoxy gallate (3). beta-D-glucopyranosyl(6'-.gluco pyranosyl(1 → 3) β-d-glucopyranosyl) 28-O-(α-l. and linoleic. Bark extract is also given orally In a study by Sehgal et al. International Journal of Pharmaceutical Sciences and Research 20 . from the stem bark of  Seed bark decoction is used as aphrodisiac.23  It is also useful in urethrorrhoea. menorrhagia and is also known to gallate (2).17%.diphenylrhamnopyranosyl) .71% accompanied by pains in various parts of the of ether extract. febrifuge. isolated body. and stigmasta-5-en-3beta-D-glucopyranoside were l-arabinopyranosyl) protobassic acid.69 and 6. and . trihydroxylbenzoate (7).5-trihydroxy benzoate wounds and ulcers.. respectively. stigmasta-5-en-3-beta- (1 → 3) β-d-xylopyranosyl(1 → 4) [α-l-rhamno ol. 4. along with the known glucuronopyranosyl) 28-O-(α-l-rhamnopyranosyl compounds: farnon-3-one.28.97. dried flowers contain long chain carboxylic acid  The bark is used as snuff for high fever ester and (Z)-9-octadecenoic acid.98.01% of the oil. their smoke is good in asthma. ulitis and ulemorrhagia and tender stems are Hazra Isolated antibacterial pentahydroxy flavones used as tooth brushes.  The bark and seed coat are used for Flower: Fresh flower contain 2-Phenylethanol. respectively. The dried (1 → 3) β-d-xylopyranosyl(1 → 4) α-l-rhamno flowers of Mimusops elengi yields four known pyranosyl(1 → 2) α-l-arabinopyranosyl) 16-α. The method provided a rapid reported for its moderate inhibitory activity and easy approach for detection and quantitation of against HIV type 1 protease. cystorrhoea. 8(1): 17-28.17 as a gargle for odontopathy treatment. 4''. pyranoside and d-quercitol. a new triterpene 3β-hydroxy-lup-20(29)-ene-23. 25. E-ISSN: 0975-8232. P-ISSN: 2320-5148 Three of them are new compounds: 3-O-(β-d. 10.  Bark is used as a tonic. Powder of dried flowers is a (6) and beta-D-(2'-phenyl glucopyranosyl)-(6'-->1'') brain tonic.(4''-ethylphenyl) leucorrhoea.

mature and ripe fruits of Mimusops reducing power and total antioxidant capacity. applied on gum heart diseases but also used as anti diuretic and teeth for strengthening them. whereas in agent in polyuria condition.  It is also used to prepare lotion for wounds and such as in constipation. Mimusops elengi bark showed antiulcer cases of constipation especially in children.  The roots are used as diuretic. activity. evaluated the agent offering effective protection from free Antioxidant potential of the methanol extract of the radicals. Study proved that it act as a chemo-preventative 1. In DPPH scavenging assay the IC50 value expressed as gallic acid equivalents (GAE) by of the extract was found to be 43. hydrophobia. The antioxidant capacity values of these fractions. 1-diphenyl- of the phenolic compounds extracted from 2-picrylhydrazyl (DPPH) scavenging assay. FIG. an expectorant and in liver complaints and  Seeds are used for preparing suppositories in asthma.  In Ayurveda.  Leaves are used as an antidote in snakebite. E-ISSN: 0975-8232. ulcers.5 ± 0.  Latex is applied to treat scabies and skin sores. of genitourinary system of males. Antioxidant activity: Saaha et al. 27 In another study antioxidant capacities leaves of Mimusops elengi by using 1. the bark is used for the diseases toxins. It alleviates the Unani system.  Floral part of the plant produce copious  Seeds bruised and locally applied within the discharge from nose. relieve headache. dried powder is a brain tonic and is piles etc. 1: DRY GUM EXUDATE OF MOLSARI (MIMUSOPS ELENGI LINN. The elengi were investigated. Total antioxidant activity was also International Journal of Pharmaceutical Sciences and Research 21 . Vol.8 mg/ g extract was 58.7 ± 4. the important preparation of  The extract of the flower is salutary not only in Mimusops is bakuladya taila.Rani and Rahman. The folklore mentions seeds to have useful to relieve cephalagia.26μg/ml while the ABTS assay for immature and mature fruits were in IC50 value of the reference standard ascorbic acid the range of 13. diabetes. sniffing is employed to anus of children in cases of constipation.1 -441. M. spermicidal properties.. flowers is used for smearing on sores and  Powder of dried flowers is a brain tonic and is wounds. 2017. P-ISSN: 2320-5148  The flowers are also used in distilling anotto  A lotion prepared from unripe fruits and used in perfumes. IJPSR. carried out on different parts of this plant: elengi extract also showed strong reducing power.  The seed is known for its medicinal properties. useful as a snuff to relieve cephalgia. 8(1): 17-28. immature.  Unripe fruit is used as a masticatory and help to cardiotonic and stomachic. hence used as an anti-toxin. The antioxidant capacity extract showed significant activities in all of each fraction was determined by radical antioxidant assays compared to the reference antioxidant ascorbic acid in a dose dependent scavenging (DPPH and ABTS) assays.92μg/ml. Flowers are used as fix loose teeth. astringent. manner.) Pharmacological Activities: Following studies are found to increase in a dose dependent manner.

001) decrease in Koti et al. 31 values of F2 ≈ F3 > F1. calcium. E-ISSN: 0975-8232. The first group aegypti and Culex quinque fasciatus. Study concluded that all the extracts tested have a diuretic showed promising antioxidant properties by potential significant quenching impact on the extent of lipid peroxidation. However. and antioxidant defense system in pancreas tissues.80 %) at a dose of 1000 μg/0. urine was collected and Allium cepa.) for diuretic activity larvicidal potential of M. studied the (200 mg/kg body weight.9% sodium chloride solution p.3 μg/mg of extract. along with enhancement of In another study Petroleum ether. 5.9% sodium chloride solution (25 compound 1. SOD.5 ± 4. (60. The aqueous stress was measured by plasma and tissue lipid extracts showed a significant diuretic activity when peroxidative markers levels. Diuretic activity/Anti Urolithiatic activity: elengi produced significant (P < 0. the be (73. petroleum ether. glutathione (GSH). and phosphate al. evaluated the diuretic activity Mimusops elengi fruits is a good source of natural of ethyl acetate. 29 alcohol extracts of bark were evaluated for antiurolithiatic and antioxidant activity in male 2. The diuretic activity was noted in the alcoholic extract GAE values for ripe fruits were in the range of however no duretic activity was observed in 192. property in peroxynitrite. chloroform. chloroform.001) lowered by curative and in the anti-inflammatory activity.3-benzodioxol. This study showed that Katedeshmukh et al. 10 mg/ml) of International Journal of Pharmaceutical Sciences and Research 22 . 2017. Rest of showed promising larvicidal activity. assessed the antioxidant and in vitro anti.85±0. MDA.o. 6 and 24 hrs.9% sodium chloride solution. investigated on meristimatic cells of root tips of After oral administration. and phosphate membrane stabilization of M.4 bis (1. Larvicidal activity: Ruikar et al.3).0 – 212.32 and alcoholic extracts of Mimusops elengi bark 4. chloroform. and CAT. 2. increased GSH. calcium. 30 preventive treatment with alcohol extract. Researchers observed that Na+ / K+ non-enzymatic antioxidants in plasma and tissues ratio was higher in aqueous extract and followed by were also studied for this plant and the oxidative ethanol and ethylacetate extracts. The leave extract recorded.3) elengi were found safe orally and exhibited no μg/mL respectively. elengi L was found to excretion grossly increased.30). the standard drug furosemide (20 mg/kg body Hexane (hex) and ethyl acetate (ea) extracts weight) in 0.5±2. 5. and catalase (CAT) hypochlorous acid models and the IC50 value were were also monitored. superoxide and superoxide dismutase (SOD). Total phenolic content was gross behavioral changes in the rats.4±5. elengi was suspended in 0.. Protective effect of leaf extract on lipid The extracts were administered orally at the dose of peroxidation and activities of both enzymatic and 250 mg/kg b.5. From results they antioxidants and enzymatic antioxidants. (202. were monitored in the urine and kidney. and alcohol of M.Rani and Rahman. The received only 0. cubebin. P-ISSN: 2320-5148 with relative capacities being F2 > F3 > F1. p.. Serum inflammatory activities of alcoholic extract of BUN..6 mg/g extract with relative chloroform and petroleum ether extracts.. studied. The experiment was carried out by volume was recorded at 5 hours. Vol. All the extracts of M. It was also observed that alcoholic extract of M.53 ±2. petroleum ether. 3. the oxalate. non enzymatic compared with other extracts. IJPSR.w. 8(1): 17-28. In hypercalculi found to be 97. and uric acid were also Mimusops elengi leaves. ethanol and water extract of antioxidant.3 ± 1. 3.5- ml/kg body weight) and the second group received yl methyl) tetrahydrofuran-2-ol was isolated. found to be (205. The maximum animals.23 in the kidneys of calculogenic rats were % at a dose of 250 μg/ml with regards to standards significantly (P < 0.5 ml and increased deposition of stone forming constituents that of protein denaturation was found to be 86. In-vitro anti-inflammatory activities: Kar et albino Wistar rats. creatinine. 28 Mimusops elengi in male wistar rats (175-200g) by measuring the urine volume at 1. Oxalate. In vivo antioxidant parameters such as exhibited dose dependent free radical scavenging lipid peroxidation (MDA).elengi against Aedes on five groupes of six animals each. The highest using different concentrations (2. 4. Cytotoxic activity: The cytotoxic effect of elengi bark in a dose of 200 mg/kg body weight ethanolic extract of barks of M. O. 34 the three groups received each of extracts viz.

decreased whole brain acetyl cholinesterase activity investigated the antipyretic and analgesic activity significantly. packed cell volume. 38 significant (p<. The extracts from the an appreciable antipyretic effect was noticed at 200 scCO2 method showed higher free radical mg/kg dose. biological activities of the M. IJPSR. Open field respective time and with increasing concentration. elengi flower extracts The methanolic extract produced significant prepared by the two non-heated processes (scCO2 antipyretic effect in a dose dependent manner and and hexane maceration). A dose dependent analgesic activity scavenging and normal human skin fibroblast was observed with significant effect at 200 mg/kg proliferation activities than those by the hexane dose. adverse reaction after the administration of a single Pretreatment with extract at doses of 100 and limit dose. Neuroprotective activity: The study 10. half of the protective effect might be attributed to the mice were dissected and the rest were kept alive for polyphenolic compounds and their antioxidant and assessment of increase in life span. p. 37 maceration. 8(1): 17-28. Light and dark box test. Researchers concluded that the observed daily for 9 consecutive days. Elevated plus maze and and mitotic index were calculated. Extract [100 and 200 mg/kg] was toward normal levels in MEME-treated mice as International Journal of Pharmaceutical Sciences and Research 23 . Antitumor activity: Kar et al. 36 Sehgal et al. Analgesic and Antipyretic attenuated amnesic deficits induced by diazepam [1 activities: The antiinflammatory activity of alcohol mg/kg. Vol. Antipyretic and analgesic activity was carried out 9.40 7. i.. i. It inflammation. cepa with respectively.] and extract of Mimusops elengi was evaluated using natural aging.Rani and Rahman. elengi [100 and 200 mg/kg] acute (carrageenan-induced paw oedema) and sub decreased transfer latencies and increased step acute (cotton pellet) in vivo models of down latencies significantly in the aged mice. elengi exhibited antiinflammatory activities in experimental animals significant anxiolytic activity in mice. Free radical scavenging and skin fibroblast on yeast induced pyrexia and tail immersion model proliferation activities: The study investigated the in rats respectively at 100 and 200 mg/kg doses. The results indicated the inoculation of EAC in mice (n = 12). and reduced the nitrite levels when compared to Twenty-four hours after intraperitoneal (i. p. E-ISSN: 0975-8232. Extract [100 and 200 mg/kg.001) decrease in tumor volume. and Parle investigated the reversal of memory Hematological. and viable cell count.) ischemic animals. MEME showed anti-inflammatory property. investigated the volume. Study revealed passive avoidance paradigm were employed to that there is a significant decrease in percent assess short term and long term memory mitotic index and root length of A. M. and in vivo deficits by ethanol extract of Mimusops elengi in antioxidant parameters were significantly restored mice.4 mg/kg. MEME was neuroprotective effect of extract against stroke like administered at 200 and 300 mg/kg body weight injury. On day 10. Acute toxicity activity: In an acute toxicity investigated the neuroprotective effect of study.w. The study revealed that 70% ethanol also reversed amnesia induced by diazepam and extract of Mimusops elengi has significant scopolamine in young mice. Antiinflammatory.]. did not produce any mortality or cerebral ischemic reperfusion injury in rats. test and Social interaction test were used to assess 35 the possible anxiolytic potentials of plant mtrial.p.] significantly 6.. and 8. Anti-amnesic activity/Anxiolytic activity: Joshi increased the life span of EAC bearing mice. After 48 h and 96 h root length young and aged mice. 2017. p. scopolamine [0. 39 of methanolic extract of leaves of Mimusops elengi. biochemical profile. It also antitumor activity in Swiss albino mice against prevented the alteration in the antioxidant status Ehrlich ascites carcinoma cells (EAC) cell line. It also at a dose of 200 mg/kg. P-ISSN: 2320-5148 standard cytotoxic drug cyclophosphamide and administered orally for 8 successive days to both ethanolic extract.o. the single administration of these extracts up hydroalcoholic extract of Mimusops elengi against to 2 g/kg b. elengi (MEME) leaves for induced by ischemia reperfusion injury. edema and extent of BBB disruption methanol extract of M. M.32 200mg/kg significantly improved the neurobehavioral alterations and reduced the infarct 11.

was observed in methanol and ethanol extract. acetone. Petroleum ether. ethanol and methanol extracts against Salmonella typhi. 43 The bark extracts in aqueous and acetone solvents The petroleum ether. Leaves extracts hours. The extracts Trichoderma viride and were inactive against were evaluated for antibacterial activity against Helminthosporium sativum. acetone. In method. 41 Chloroform extract showed prominent antibacterial activity in preliminary screening. toluene. Hazra et al. The ethanolic extract of bark was tested for Methanolic and aqueous extracts showed greater antibiotic activity using the well method on 16 activity as compare petroleum ether and acetone clinical bacterial isolates seeded in Mueller Hinton extracts because more phytoconstituents were Agar. 2017. the MIC agar dilution method. Individual extracts of bark were prepared displayed good activity against Bacillus subtilis and with chloroform. ethanol and chloroform extract of leaves was investigated against five pathogenic bacteria Anti microbial effect was also tested by hexane. Vibrio cholera and Streptococcus the dental caries causing bacteria Streptococcus pneumonia by using agar cup diffusion method. aureus. Staphylococcus than aqueous extracts. IJPSR. Proteus vulgaris.44 Streptococcus sanguis. chloroform. 8(1): 17-28. against gram positive and gram negative bacteria. Minimum Inhibitory Concentrations (MICs) using methanol. E-ISSN: 0975-8232. The ethanol bark fruits and leaves were screened for their extract shows significant activity against three antibacterial against some pathogenic bacteria. tartar of dental patients by ditch plate technique. Bacillus cereus. Pseudomonas aeruginosa. The ethanol extracts were more potent faecali. ethyl acetate. Gram negative International Journal of Pharmaceutical Sciences and Research 24 . ethyl acetate. Vol. Escherichia coli. 42 purified by column chromatography. inhibition in this study. chloroform. Escherichia coli. P-ISSN: 2320-5148 compared to EAC control. extracts did not show any significant zones of Streptococcus mutans. The aqueous and acetone microorganisms such as Staphylococcus aureus. The The aqueous extract showed a strong antibacterial all extracts showed antibacterial activity against activity. The compounds showed strong inhibitory activity In another study aqueous petroleum ether. Klebsiella pneumoniae.46 12. The antibiotic activity were tested for their leached in it. kanamycin solvent extracts of bark. mutans isolated from caries infected patients. detected. ethyl The antibacterial activities of both aqueous and acetate and methanol extracts of the flowers of ethanolic extracts of leaf were screened against Mimusops elengi were screened against various medically important bacterial strains by using both pathogenic Gram positive and Gram negative agar disc diffusion and agar well diffusion bacterial strains viz. Antibacterial activity: The antibacterial activity of petroleum ether.Rani and Rahman. Enterobacter methods. Lactobacillus acidophilus and Candida albicans by well diffusion method. MEME also showed microorganisms and organisms isolated from tooth direct cytotoxicity on EAC cell line in a dose. Pseudomonas aeruginosa M. Staphylococcus isolates including Staphylococcus Fruit extracts were less potent against most of the aureus.. Maximum and highly significant activity Streptococcus mutans. Methanolic flower extract of Mimusops order to isolation of antibacterial pentahydroxy elengi showed pronounced antibacterial activity flavones from the seeds of mimusops elengi the against all the microorganisms tested with 25.45 The bark was extracted successively with tested organisms compared to those obtained from petroleum ether. Salmonella paratyphi. dependent manner. bark and leaves and were inactive against the methanol and water in a Soxhlet extractor for 18 fungus Trichoderma viride. benzene. compounds were extracted by ethyl acetate and 30mm/50µL inhibition zone. Streptococcus salivarius. 50 different Gram positive.16 methanol. two antibacterial and Serratia marcescens by ‘agar well diffusion’ compounds from the seeds of mimusops elengi. methanol and water were also evaluated and compared for antibacterial extracts of bark were tested for their antibacterial activity against salivary microflora using paper disc activity against five dental infection diffusion method. methanol and water.

Besides. Extract at of a standard drug Betadine ointment in terms of 50 and 100mgkg doses showed significant wound contracting ability. caused The bark extracts were found to be active against corresponding reductions of 81 and 64% in extract- most of the tested fungal strains and the all extracts induced hypotension. The extract 100mgkg showed dose-dependent inhibition of ointments showed considerable response in all the gastric lesions against ethanol-induced gastric above said wound models as comparable to those damage. In vitro antioxidant and in vivo antihyperglycemic activity: Ganu and Jadhav 18. Extract also showed the methanolic extract ointment of Mimusops increase in the mucosal glycoproteins that was elengi effectively stimulated wound contraction. Albendazole was was at the 2nd hr and duration of action was before included as standard reference and distilled water the 24th hr.05) when compared with significant wound healing. Significant tensile strength and dry granuloma weight. Wound Healing Activity: In an study wound against experimental gastric ulcers. total acid output proposal that Mimusops elengi bark extract exhibits and pepsin activity (P<0. Antifungal effect: The hexane. 50 and and dead space wound model. IJPSR. obtained from fruits displayed weak activity against elengi might possess calcium-blocking activity most of the fungi whereas the extracts of leaves which would explain its hypotensive effect. On intravenous administration groups treated with methanolic extract showed International Journal of Pharmaceutical Sciences and Research 25 .56 The petroleum ether extract.9mg/kg). P-ISSN: 2320-5148 13.9 antifungal activities against some pathogenic fungi. Authers concluded that extract may act as control. evident from significant rise in total carbohydrates increase tensile strength of incision and dead space to protein ratio (TC:PR ratio) (P<0. methanol. wound closure time.o. ethyl unchanged after autonomic ganglion or angiotensin acetate. muscarinic and show any antifungal activity against Candida histaminergic receptors. The extracts did not independent of adrenergic. The results indicated that the Extract exhibited reducing power as well as DPPH methanolic extract and ethyl acetate fraction of the and OH radical scavenging activity in vitro. Anti ulcer activity: Shah investigated the effect of 50% alcoholic extract of Mimusops elengi 14. ethyl acetate. fruits and leaves were screened for their calcium channel blockers. Hypotensive activity: The methanolic extract extract of bark was used for the evaluation of of Mimusops elengi showed hypotensive activity in antihyperlipidemic activity on wistar rats. Antihyperlipidemic activity: The methanolic 16. These data imply that M. Extract at the doses of 10.Rani and Rahman. Onset leaves has significant anthelmintic activity with of action of antihyperglycemic activity of extract respect to standard and control. fluconazole solvent extracts of -converting-enzyme blockade. Extract also wounds as compared to control group. Anthelmintic activity: The methanolic extract evaluated the in vitro antioxidant and and its fractions were evaluated for anthelmintic antihyperglycemic property of aqueous extract activity by using adult Indian earthworms Mimusops elengi in alloxan-induced diabetic rats. E-ISSN: 0975-8232. Pheretima posthuma.) against ethanol-induced gastric wound models on mice: the excision.53 showed considerable inhibitory effect against most of the tested fungi . The anaesthetized rats. (i. 52 showed protection against water-immersion plus stress-induced gastric lesions.) at a dose range of 2–16 mg/kg. The hypotension was also albicans.v. Vol. it produced ethanol and methanol extracts were tested against about a 7–38% fall in mean arterial blood pressure. This study showed that the control group. Administration of bark. A methanolic extract was ethyl acetate n-butanol methanol and aqueous were examined in the form of ointment in three types of studied (p. the dental caries fungus Candida albicans isolated in a dose-dependent manner. including nifedipine (0.05). 2017. reduction in ulcer index (P<0. reduction was also observed in total acidity.51 17. the incision damage.05).52 19. The effect was from caries infected patients. mg/kg) and verapamil (3. In 19h pylorus-ligated animals. The Mimusops healing activity of extract of bark part of Mimusops elengi extract and its different fractions namely elengi was evaluated. 55 by increasing peripheral utilization of glucose. 54 15. Histological analysis was also consistent with the volume of gastric acid secretion. 8(1): 17-28.

2010. new drugs from natural sources. metabolites from the flowers of Mimusops elengi Linn. it elicits on all Phytochemistry Journal. Secondary the treatment of a variety of disorders like fevers. and Medicine. Mimusops elengi: A Review on Ethnobotany. Sharlene C. New Delhi: Central Council of Research in Unani anthelmintic. Delhi: Central Council of Research in Unani Medicine. 561. p67. Patil MJ. Kadam VB. 57 REFERENCES: 1. Laskar S.210. Kadam PV. throat pain. Misra G. Khazainul Advia. The Wealth of India. Anti-atherosclerotic activity: The methanol callus from node of Mimusops elengi. headache. Massiot G. P-ISSN: 2320-5148 significant reduction in levels of triglyceride and new formulations which can be beneficial for the total cholesterol as compared to hyperlipidemic treatment of various ailments group after 7 and 24 h of induction which indicates its antihyperlipidemic potential. 2012. diuretic. 1496-99. Anonymous. New Delhi: Pharmacological activities like antimicrobial. p246. 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4(6): 871-874.8(1). Shah MB. Investigation of Wound Healing (Sapotaceae) leaf. Phytomedicine 1999. Activity of Methanolic Extract of Stem Bark of Mimusops 56. Jain U K. Sumithra M. E-ISSN: 0975-8232.): a boon drug of traditional medicine. Goswami SS. 2011. Agarwal V. J Pharm Res 2011.doi: 10. Antihyperglycemic Potential of Mimusops elengi L. Afr J Tradit Complement Altern Med. Behbahanian DS. Garud A. Scan QR Code using Code/Bar Scanner from your mobile. 2(6):293–300. In Vitro Antioxidant and In Vivo 4(9):2938‐2940. atheroma in rats. Int J Pharm Sci Res 2017. Dhanamjayarao M. Jana GK. 8(1): 17-28. How to cite this article: Rani S and Rahman K: Molsari (Mimusops elengi Linn. Kshirsagar A. IJPSR. 6(5):373‐378. Anticonvulsant activity of a Mimusops Complementary and Integrative Medicine 2010. 4(9):2938‐2940. Gandhi MS. Evaluation of Biological Sciences 2008. 7(1): elengi in experimental animals. Jadhav S. Hypotensive effect of 58. elengi in experimental animals. 52. 51.Rani and Rahman. 3(10):2514‐ 2515. Alloxan-Induced Diabetes in Mice. 2017. Jadhav S. Int J Adv Pharmaceut Res 2011. Research Journal of Agriculture and 55. anthelmintic potential of Mimusops elengi linn. Malik A. Ganu G. Vol. (Scanners are available on Google Playstore) International Journal of Pharmaceutical Sciences and Research 28 . Satishchandra.0 Unported License. J Pharm Res 2011. Jahan N.13040/IJPSR. 8(1): 17-28. P-ISSN: 2320-5148 elengi Linn. 1553-3840. Shah PJ. Jadhav S. This Journal licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3. Synergistic effect of the methanolic extract of Mimusops elengi in Mimusops elengi and Moringa on high fat diet induced normotensive rats.0975-8232. Talele S. Gupta N. Talele S. Vani M. Agarwal V.17-28. elengi Linn. Journal of Kshirsagar A. Ganu G. All © 2013 are reserved by International Journal of Pharmaceutical Sciences and Research. J Pharm Res 2010. 53. in 57. Garud A. This article can be downloaded to ANDROID OS based mobile. Study of Mimusops elengi bark in experimental gastric ulcers. 54. 89(2-3):305-11. Ganu G. Anticonvulsant activity of a Mimusops 8(2): 98-103. J Ethnopharmacol 2003. Santani D.