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Pedia2nd sem midterm 2013-2014

Topic :pediatric pharmacotherapeutics,essential intrapartum newborn care,neuro, immunology

1.gastric emptying time in newborn


A,5hrs b.7hrs c.9 hrs d.10 hrs

2.skin testing in neonates to detect allergy to penicillin and other drugs will not be informative
because
Ans. Absence of histamine in neonatal skin until third week of life.

3.which of the following statement is true regarding inhalational absorbation?


a. nebulizers is proven to be dangerous to use at home
b. spacers are effective in younger children including as young as 3 months.
c. both
d.none

4.At birth cytochrome P 450 is ..%of adult level


a.22 b.28 c.30 d. 32

5.Mechanism by which the chemical or drug is altered


a. drug metabolism b. drug transformation c.drug modification
6.Which of the following reaction is in 2nd phase of drug biotransformation?
a. glucoronidation b. sulfation c. glycine coupling d.hydroxylation
7.GFR is ..%of adult level
a.20-30 b. 30-40 c.40-50 d.50-60

8.glomerular filtration reaches adult level at what age ?


A.2 yrs b. 3month c. 3 yrs d. 4 month

9.which of the following statements is true?


a.metabolism rate is decreased by 10% for each degree rise In temp.
b.extraction ratio is the fraction of drug removed from the blood during a single pass thru the
liver

10.the efficiency with which the liver irrerversibly removes drug from the blood and for highly
bound drug?
A. hepatic clearance b. extraction ratio c.extraction efficiency of drug d. none

11.which of the following is in category B ?


a.animal fetal toxicity demonastrated ;human risk undefined
b.no controlled studies show human risk ;animal studies suggest potential toxicity

12.which of the following drug is cell wall synthesis inhibitor?


A.vancomycin b. isoniazid c.sulfonamides d. chloram phenicol

13. which of the following drug is protein synthesis inhibitor?


a.clindamycin b. fluroquinolones c. rifampicin D. trimethoprim

14. anti-pseudomonas penicillin is


a.oxacillin b.nafcillin c.methicillin d. ticarcillin

15 .pathophysiologic changes that can alter the drug disposition except


a. Hypoproyeinemia b. hypolipoproteinemia c.increased TBW
d.increased fat

IMMUNOLOGY

16. The most common well defined immunodeficiency d/o:


a. common variable immunodeficiency b. selective IgA deficiency
c. severe combined immunodeficiency d. X-linked agamagobulinemia

17. Cell responsible for the elimination of intracellular organism:


a. B cells b. NK cells c. T cells

18.the immunoglobulin immediately present at birth


a. Ig G B.IgM C. Ig A d. all

19. The immunoglobulin thru crosses thru placenta


a. Ig G B.IgM C. Ig A d. all

20.functions of immune system


a. defense b. homeostasis c. perception and destruction of altered cells d.all

21.Supression of immune response is mediated by


a. TH1 b. TH2 c. regulatory T lymphocytes d. NK cell

22. failure of appropriate recognition


a. autoimmunity b. hypersensitivity c. immunodeficiency d.none

23.the following are recurrent infections except


a. More than 2 pneumonias in 1 year
b. More than 4 new ear infections in 1 year
c. More than 6 to 8 upper respiratory tract infections in 1 year
E. ALL

EINC
1.the temperature of the delivery area should be kept at degree celcisus
a.18-20 b. 22-24 c.25-28 29-32

2.you are call to attend a mother about to deliver a baby in a pedicab.after the baby is
born ,the first action that must be immediately done is
A.clamp and cut the cord b. dry the baby
c.milk the cord towards the newborn d.do skin to skin contact between mother and
newborn

3.the following are brestfeeding cues except


A.licking b. tonguing c. tossing or turning d. crying

4. benefits of properly timed cord clamping help in


a.less anaemia in term b. less anaemia in preterm
c.less IVH in preterm d. prevent postpartum hemorrhage

5.Advantage of antenatal steroids,except?


a.reduction in mortality b prevent cerebroventricular hemorrhage
c. prevent preterm labor d.

Neuro part
1. A3 month old child was brought for well body consult. The following should make
you suspect of a possible developmental problems:
a. b.No response of cooing
c. . Of the extremities d. All of the above
2. Vision in an infant is assessed by:
a. Blink reflex to light b. Reaching out for objects
c. Tracking objects d. All of the above

3. Microcephaly is suspected when:


a. Head circumference at birth is 34-35cm b. Anterior fontanel is closed by 18 months
c. HC is 2 standard deviation below the mean for age
d. Posterior fontanel is closed by 3 months
4. In assessing for motor function, the following should be observe:
a. Handedness b. Position of the extremities at rest
c. Symmetry of movements d. All of the above
5. Mental status evaluation of a child includes:
a. Level of consciousness b. Language function according to age
c. Social interaction and play activity d. All of the above

6.which of the following congenital infectious of nervous system?


a.CMV b. rubella c. toxoplasmosis d. all
7.Which of the following diagnostic test is done for meningitis?
a.CSF exam b. cranial CT scan c. MRI d.contrast CT scan

8.which of the following characteristics will suspect bacterial meningitis?


a. nuchal rigidity b.new onset of seizure c. ppilledema d. focal neurologic deficit e.
abnormal level of consciousness f.all

9. which of the following statement true of migraine?


a) Headache upon sleeping
b) Headache upon wakening up
c) Irritation, vomiting
d) All of the above

10) True about Brain tumor


a) Progressive
b) Papilledema
c) Neurological deficit
d) All of the above

11) True to differentiate bacterial and viral


a) Wbc in chronic contains lymphocytes
b) Bacteria less sugar
c) Bacterial csf gram stain is usually positive
d) All of the above

12. which of the following statement is true?


a b. hydrocephalous and infraction are the characteristic of bacterial
meningitis.
c. Cryptococcus cause acute meningitis d. all