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Max. Questions: 200 BIOCHEMISTRY AND CELL BIOLOGY Max.

Time: 2 hrs
BASIC SCIENCE
Single Option Multiple Choice Questions. Practice Set
Choose the most appropriate/correct answer.
Thereis no negative marking for Wrong answer. Email: sidharta123@yahoo.com

1. Which of the following statements regarding melting point of fatty acids is INCORRECT?

a. melting point of stearic acid is 69\C


b. melting point of linolenic acid is -10\C
c. melting point of oleic acid is 25\C
d. melting point of linoleic acid is -5\C

2. Mark the most INCORRECT statement about Chromosomes:

a. kinetochore assist in the formation of spindles during mitosis


b. chromosomes consists of two types of constrictions
c. satellite is separated from the main chromosome by a primary constriction
d. chromatids join at centromere
e. primary constrictions consists of kinetochore and centromere

3. All of the following are basic amino acids EXCEPT:

a. Histidine
b. Lysine
c. Arginine
d. Leucine

4. Y. pestis is highly sensitive to all of the following drugs EXCEPT:

a. chloramphenicol
b. tetracyclines
c. penicillin
d. streptomycin

5. All of the following are correct about Phloem EXCEPT:

a. primary phloem lacks phloem fibres


b. consists of meristematic cells
c. conducts food from leaves to other parts
d. consists of companion cells
e. consists of sieve tubes

6. All of the following procedures can be used for protein precipitation EXCEPT:

a. Heat coagulation
b. Alcohol
c. Iso-electric Precipitation
d. Salting out
e. Ingram's technique

7. A copper containing mixed function oxidase-

a. Enolase
b. Tyrosinase
c. Xanthine oxidase
d. Catalase
e. Hexokinase

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8. Polycistronic mRNA:

a. nonprotein-coding segment of DNA


b. contains information for amino acid sequences of a single polypeptide
c. contains information for amino acid sequences of different polypeptides
d. Eukaryotic mRNA is always polycistronic
e. Prokaryotic mRNA molecules are always monocistronic

9. Globular proteins:

a. protamines
b. histones
c. mucoproteins
d. peptones
e. elastin

10. Which of the following amino acids is purely glucogenic?

a. histidine
b. isoleucine
c. leucine
d. phenyl alanine
e. tyrosine

11. All of the following agents are goitrogens (prevent uptake of iodine by the thyroid gland) EXCEPT:

a. radish
b. cauliflower
c. mustard oil
d. rape seed oil
e. cabbage

12. Which of the following Trinucleotide sequence repeats are associated with Huntingon's chorea?

a. CUG repeats
b. CGG repeats
c. CTG repeats
d. CAG repeats

13. Regarding folate deficiency, mark the INCORRECT statement:

a. macrocytic anemia
b. dUMP is conversted to dUTP
c. thymidylate enzyme is inhibited
d. dUMP is conversted to dTMP
e. characterized by leukopenia

14. The number of haploid set of chromosome in Garden pea is

a. 12
b. 21
c. 7
d. 5
e. 24

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15. Which of the following Shigella species ferments lactose?

a. Shigella flexneri
b. Shigella sonnei
c. Shigella boydii
d. Shigella dysenteriae

16. Which of the following is a 19-carbon steroid?

a. progesterone
b. testosterone
c. dehydroepiandrosterone
d. deoxycorticosterone

17. ATP generated in ETC by oxidation of FADH

a. 12
b. 2.5
c. 3
d. 2
e. 32

18. Which of the following is most injurious to health?

a. Elaidic acid
b. Linolenic acid
c. Pentaenoic acid
d. Oleic acid

19. Which of the following is the least dense of the blood lipoproteins

a. Intermediate-density lipoprotein (IDL)


b. Low-density lipoprotein (LDL)
c. Chylomicrons
d. High-density lipoprotein (HDL)
e. Very-low-density lipoprotein (VLDL)

20. Which of the following enzymes is Mitochondrial?

a. orotate phosphoribosyl transferase


b. Prolidase
c. OMP decarboxylase
d. carbamoyl phosphate synthetase-II
e. carbamoyl phosphate synthetase-I

21. A vitamin that acts as a coenzyme for carboxylation reactions

a. Pyridoxine
b. Thiamin
c. Biotin
d. Riboflavin
e. Niacin

22. RNA involved in protein biosynthesis:

a. mRNA
b. SnRNA
c. rRNA
d. tRNA
e. miRNA

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23. Which of the following amino acids is purely Glucogenic?

a. tryptophan
b. tyrosine
c. serine
d. lysine
e. leucine

24. Which of the following is not a function of Phospholipids?

a. emulsification of dietary lipids


b. formation of triacylglycerols
c. formation of biomembranes of brain and muscles
d. absorption of lipids
e. membrane fluidity

25. The number of haploid set of chromosome in Triticum aestivum is

a. 24
b. 21
c. 26
d. 23
e. 22

26. Insulin induces the following enzyme:

a. Fructose-1,6-bisphosphatase
b. Phospho enol pyruvate carboxy kinase
c. Pyruvate kinase
d. Glucose-6-phosphatase

27. Which of the following is/are NOT Pseudomonads?

a. Ralstonia pickettii
b. Pseudomonas aeruginosa
c. Burkholderia pseudomallei
d. Stenotrophomonas maltophilia
e. Eikenella corrodens

28. The precursor of Glutathione is:

a. formimino glutamic acid


b. glutamic acid
c. glycine
d. histidine
e. glutamine

29. All of the following are correct about Cambium EXCEPT:

a. consists of meristematic cells


b. generally have 2-3 layers
c. may be vascular in Coleus
d. consists of sieve tubes
e. may form new cells during secondary growth

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30. Seborrheic dermatitis occurs due to the deficiency of:

a. pyridoxine
b. cobalamin
c. niacin
d. folic acid
e. riboflavin

31. Enzyme deficiency or abnormality in Homocystinuria type 2-

a. Ornithine decarboxylase
b. Cystathionine beta synthase
c. Methylene THFA reductase
d. Homogentisic acid oxidase
e. Methyl transferase

32. All of the following are intermediates in pyrimidine nucleotide synthesis EXCEPT:

a. uridylic acid
b. orotic acid
c. inosinic acid
d. uridine diphosphate
e. carbamoyl aspartate

33. Vascular bundle consists of all of the following EXCEPT:

a. cambium
b. xylem
c. phloem
d. pericycle

34. One of the following statements about Sickle cell anemia is INCORRECT:

a. ASO (allele-specific oligonucleotide) probe can be used to detect sickle cell mutation
b. sickle cell mutation occurs in Beta globin chain
c. due to point mutation
d. mutation of GTG-to-GAG, (valine to glutamate)
e. it is a genetic disorder of hemoglobin

35. A Selenium containing enzyme:

a. glutathione peroxidase
b. tyrosinase
c. superoxide dismutase
d. urease
e. methylcoenzyme reductase

36. Apoprotein apo A-I:

a. component of HDL-3
b. inhibits LCAT
c. blood level is 100 mg/dl
d. component of LDL
e. blood level is 150 mg/dl

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37. An example of diamino monocarboxylic
acid:

a. arginine
b. leucine
c. valine
d. histidine
e. alanine

38. In patients with Homocystinuria, there is a deficiency or abnormality of enzyme-

a. Ornithine decarboxylase
b. Xanthine oxidase
c. Cystathionine beta synthase
d. Homogentisic acid oxidase
e. Branched chain keto acid decarboxylase

39. Normal serum value of alkaline phosphatase (ALP):

a. 10-30 U/L
b. 10-80 U/L
c. 15-100 U/L
d. 13-35 U/L
e. 40-125 U/L

40. A magnesium containing enzyme:

a. Enolase
b. Hexokinase
c. Lipase
d. carboxy peptidase
e. Lecithinase

41. Trypsin is an example of

a. Hydratases
b. Transferases
c. Isomerases
d. Hydrolases
e. Lyases

42. NOT true regarding aldosterone:

a. controls transport of sodium ions in sweat glands


b. acts on the distal tubules
c. decreases potassium ion excretion
d. increases potassium ion excretion

43. An enzyme found in the inner membrane, inner surface of mitochondria:

a. Succinate dehydrogenase
b. Glycerol-3-phosphate dehydrogenase
c. Acyl CoA synthetase
d. Mono amino oxidase
e. Adenylate kinase

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44. All of the following amino acids are Glucogenic EXCEPT:

a. valine
b. aspartic acid
c. leucine
d. cysteine
e. glutamine

45. Pauly's test for histidine gives what color?

a. cherry-red
b. dark-blue
c. red
d. pink
e. purple

46. Apoprotein apo B-48:

a. component of HDL-2
b. component of LDL
c. produced by the liver
d. component of chylomicrons
e. blood level is 100 mg/dl

47. Which of the following glycosamino glycans (GAG) does NOT contain any uronic acid?

a. Keratan Sulphate
b. Chondroitin Sulphate
c. Heparin
d. Dermatan Sulphate
e. Hyaluronic Acid

48. A thiamine pyrophosphate dependent enzyme:

a. Kynureninase
b. Xanthine oxidase
c. Transketolase
d. Aldehyde dehydrogenase
e. ALA synthase

49. Regarding folic acid and FIGLU:

a. dUMP is conversted to dTMP


b. macrocytic anemia
c. normally <20 mg if FIGLU is excreted in urine per day
d. FIGLU value in increased in folate deficiency
e. characterized by leukopenia

50. In eukaryotes, the process of transcription is carried out by the enzyme:

a. Aminoacyl-tRNA Synthetase
b. RNA polymerase
c. DNA polymerase
d. Reverse transcriptase

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51. Normal blood level of Chloride is:

a. 96-106 mEq/L
b. 136-145 mEq/L
c. 3-4 mg/dl
d. 1.8-2.2 mg/dl
e. 3.5-5 mEq/L

52. Spot the WRONG statement about monocot roots:

a. no secondary growth
b. xylem is polyarch
c. xylem is tetrarch
d. large central pith
e. conjunctive tissue is sclerenchymatous in maize

53. Which of the following apoprotein fraction causes activation of LCAT?

a. apo C-ll
b. apo A-II
c. apo B-100
d. apo C-1
e. apo E

54. An activator of Carnitine acyl transferase:

a. Insulin
b. Glucagon
c. Malonyl CoA
d. Fatty acylCoA

55. CORRECT about 'Atkins diet' for obesity:

a. high fat, low carbohydrate, high protein


b. None of the above
c. high fat, low carbohydrate, low protein
d. low fat, low carbohydrate, high protein
e. low fat, high carbohydrate, low protein

56. Which of the following is NOT a derived lipid?

a. dolichols
b. triglycerides
c. steroids
d. leukotrienes

57. Beriberi occurs due to the deficiency of:

a. thiamin
b. niacin
c. folic acid
d. pyridoxine
e. biotin

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58. Which of the following is NOT a lipotropic factor?

a. Selenium
b. Leptin
c. Choline
d. Methionine
e. Lecithin

59. 'L shaped' eukaryotic chromosomes are

a. telocentric
b. metacentric
c. acrocentric
d. sub-metacentric

60. Which of the following statements is INCORRECT?

a. saturated fatty acids have higher melting point than unsaturated fatty acids
b. saturated fatty acids have lower melting point than unsaturated fatty acids
c. unsaturated fatty acids have lower melting point than saturated fatty acids
d. linolenic acids are polyunsaturated fatty acids
e. strearic acid contains no double bond

61. Biological oxidation: mark the INCORRECT statement(s).

a. also known as oxidative phosphorylation


b. oxidation is carried out by dehydrogenase enzymes
c. electron transfer from reduced coenzymes to oxygen
d. energy is released is this process
e. energy is expended in this process

62. Which of the following contains highest amount of saturated fatty acids?

a. Ox Tallow
b. Palm oil
c. Mustard (rapeseed) oil
d. Pig Lard

63. Regarding degeneracy of the genetic code, Glycine has

a. 6 codons
b. 2 codons
c. 3 codons
d. 4 codons

64. Protein cytochrome b is a component of which step of electron transport chain (ETC)?

a. Complex IV
b. Complex III
c. Complex I
d. Complex II

65. Which of the following is a precursor of prostaglandins?

a. Propionic acid
b. alpha-Linolenic acid
c. Oleic acid
d. Linoleic acid
e. Arachidonic acid

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66. Which of the following statements is INCORRECT about Uronic acid pathway?

a. catalyzes the conversion of glucose to glucuronic acid


b. L-Gulonolactone is an intermediate
c. also known as alternative oxidative pathway for glucose
d. lead to the generation of ATP

67. The most common lethal autosomal recessive disorder of the Caucasians:

a. Cystic fibrosis
b. MCADdeficiency
c. Reye syndrome
d. Gilbert syndrome
e. Crigler-Najjar syndrome

68. Which of the following is a serine protease inhibitor?

a. Alpha-1 Anti-trypsin
b. protein C
c. elastase
d. thrombin
e. cathepsin

69. All of the following are conjugated proteins EXCEPT:

a. Histones
b. Rhodopsin
c. Hemoglobin
d. Ferritin
e. Ceruloplasmin

70. Orotic acid is a biological precursor of

a. Purines and pyrimidines


b. Adenylic acid and guanylic acid
c. Cytidylic acid and Uridylic acid
d. Urea

71. Fluoride inhibits enzyme enolase by removing which ions?

a. selenium
b. zinc
c. molybdenum
d. manganese
e. magnesium

72. Bile salts contain all EXCEPT:

a. glycochenodeoxycholic acid
b. Taurochenodeoxycholic acid
c. Taurocholic acid
d. Glycocholic acid
e. Chenodeoxycholic acid

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73. Which of the following enzymes show absolute specificity?

a. glutamate aminotransferase
b. glucokinase
c. hexokinase
d. proteases
e. urease

74. Which of the following apoprotein fraction specifically binds LDL receptor?

a. apo B-100
b. apo A-I
c. apo C-1
d. apo C-ll
e. apo E

75. Decarboxylation of which amino acids produces Cadaverine?

a. Arginine
b. Tyrosine
c. Leucine
d. Lysine
e. Ornithine

76. INCORRECT about Erythropoietin (EPO):

a. is a glycoprotein hormone
b. functions as a cytokine
c. involved in wound healing process
d. is a peptide hormone
e. secreted by renal peritubular capillary endothelial cells

77. Which of the following amino acids is NOT glucogenic?

a. histidine
b. leucine
c. valine
d. asparagine
e. alanine

78. An enzyme which is activated by magnesium:

a. alkaline phosphatase
b. pyruvate dehydrogenase
c. xanthine oxidase
d. 5'-de-iodinase
e. glutathione peroxidase

79. Mark the most INCORRECT statement regarding Chromatin:

a. chromatin contains DNA and RNA


b. nucleosome has a core of eight histone subunits
c. chromatin contains non-histone proteins
d. chromatin is formed by nucleosomes
e. chromatin consists of six types of histones

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80. All of the following are conjugating agents EXCEPT:

a. Sulfate
b. Cysteine
c. Glucuronic acid
d. Bilirubin
e. Acetic acid

81. The color complex formed by amino acids when heated with ninhydrin

a. red
b. yellow
c. purple
d. black
e. violet

82. Catecholamines are secreted from ____ of adrenal gland.

a. zona fasciculata
b. zona glomerulosa
c. medulla
d. zona reticularis

83. The activation of acetoacetate to acetoacetyl CoA is catalyzed by the enzyme

a. HMG CoA reductase


b. Thiophorase
c. 7-alpha-hydroxylase
d. Acetyl CoA synthase

84. All of the following are correct about Cambium EXCEPT:

a. responsible for growth in plants


b. vascular cambium gives rise to secondary xylem
c. consists of meristematic cells
d. vascular cambium gives rise to primary xylem
e. may be vascular in Coleus

85. An example of Triose:

a. Ribulose
b. Arabinose
c. Erythrose
d. Glyceraldehyde
e. Mannose

86. HACEK group infection includes all of the following EXCEPT:

a. Actinomycetes naeslundii
b. Hemophilus aphrophilus
c. Kingella kingae
d. Actinobacillus actinomycetemcomitans
e. Cardiobacterium hominis

87. Which of the following is INCORRECT about the composition of human body fat?

a. 15% stearic acid


b. 50% oleic acid
c. 10% linoleic
d. 25% palmitic acid

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88. Virulence associated factors of Y. pestis include all EXCEPT:

a. pesticin 1
b. fibrinolysin
c. coagulase
d. hemolysin

89. 18-carbon steroids:

a. have estrogenic activity


b. aromatization occurs in the testes
c. have androgenic activity
d. include aldosterone

90. The net generation of ATP in citric acid cycle:

a. 32 ATP
b. 20 ATP
c. 12 ATP
d. 38 ATP
e. 2 ATP

91. Which of the following is a Glycosphingolipid?

a. Sulphated gangliosides
b. Cerebrosides
c. Sphingomyelin
d. Choline plasmalogen
e. Cephalin

92. Normal cholesterol concentration of blood in a human weighing 70 kg

a. 100-220 mg/100 ml
b. 140-220 mg/100 ml
c. 160-240 mg/100 ml
d. 100-180 mg/100 ml
e. 150-250 mg/100 ml

93. Which of the following enzymes is NOT involved in the urea cyle?

a. carbamoyl phosphate synthetase-II


b. ornithine transcarbamoylase
c. arginase
d. carbamoyl phosphate synthetase-I
e. argininosuccinate synthase

94. All of the following are trace elements EXCEPT:

a. iron
b. zinc
c. copper
d. manganese
e. magnesium

95. An example of Oxidoreductase:

a. Hexokinase
b. Acetyl CoA carboxylase
c. Glutamine synthetase
d. Succinate dehydrogenase

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96. Which of the following is a 24-carbon compound?

a. pregnenolone
b. bile acids
c. cholesterol
d. testosterone
e. cortisol

97. Enzyme phosphorylase kinase a is inactivated by:

a. inhibitor-1
b. protein phosphatase-1
c. cAMP-dependent protein kinase
d. glycogen synthase a
e. phosphorylase kinase b

98. An inhibitor of Glycogen phosphorylase:

a. Acetyl CoA
b. insulin
c. ATP
d. glucagon

99. Which of the following consists of Tracheids?

a. pith
b. vessels or tracheae
c. phloem
d. xylem
e. cambium

100. Oil having a highest content of PUFA:

a. gingelly oil
b. corn oil
c. seasame oil
d. cotton seed oil
e. sunflower oil

101. A Pyridoxal phosphate (PLP) dependent enzyme:

a. Aldehyde dehydrogenase
b. Transketolase
c. Pyruvate dehydrogenase
d. Kynureninase
e. Pyruvate Carboxylase

102. Glycine can be obtained from all EXCEPT:

a. arginine
b. choline
c. threonine
d. serine

103. Hormone sensitive lipase:

a. increased in starvation
b. inhibited by glucagon
c. increased in fed state
d. activated by insulin

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104. Deficiency of which Vitamin is associated with Wernicke-Korsakoff syndrome?

a. thiamin
b. folic acid
c. niacin
d. pyridoxine
e. biotin

105. Which of the following RNAs is moderately stable?

a. SnRNA
b. mRNA
c. tRNA
d. rRNA
e. miRNA

106. Urocanic acid is derived following deamination of:

a. histidine
b. glutamate
c. FIGLU
d. glutamic acid
e. arginine

107. Xanthoproteic test is used for detection of

a. arginine
b. histidine
c. phenylalanine
d. cysteine

108. Rennin:

a. deficiency may cause hypoaldosteronism


b. is a chymosin
c. is an aspartyl protease
d. secreted by the kidney
e. involved in fluid balance

109. Which of the following amino acids contains a guanidinium group?

a. Proline
b. Tyrosine
c. Tryptophan
d. Arginine

110. Which of the following is a monosaccharide?

a. Xylose
b. Lactose
c. Maltose
d. Amylose
e. Sucrose

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111. Regarding proteins at Iso-electric pH (pI):

a. viscosity will be maximum


b. precipitation will be maximum
c. will migrate faster in an electrical field
d. pI of human hemoglobin is 4.7
e. pI of human insulin is 6.4

112. The precursor of bile acids

a. Taurocholic acid
b. Cholestanol
c. Cholic acid
d. Cholesterol
e. Chenodeoxycholic acid

113. All of the following are intermediates of pyrimidine synthesis EXCEPT:

a. uridylic acid
b. carbamoyl aspartate
c. orotic acid
d. uridine diphosphate
e. inosinic acid

114. The number of haploid set of chromosome in Homo sapiens is

a. 24
b. 26
c. 23
d. 21
e. 22

115. The site of action of hormone sensitive lipase

a. adipocyte
b. mouth
c. stomach
d. small intestine
e. capillary wall

116. Pick the INCORRECT inferences derived from Mendel's pea plant experiments:

a. sexual reproduction causes segregation of genes


b. traits are carried by genes
c. alleles for traits separate independently of one another
d. hidden variations are recessive
e. genes blend but do not change from one generation to the next

117. Which of the following statements about the metabolism of chylomicrons is INCORRECT?

a. synthesis of apolipoprotein-B begins on the rough ER


b. Chylomicron remnants have small size but high density
c. triacylglycerol (TAG) account for about 90% of the lipids in chylomicron
d. TAG of chylomicron is degraded by lipoprotein lipase
e. synthesis and transfer of Lipoprotein lipase is inhibited by insulin

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118. A purely ketogenic amino acid:

a. leucine
b. alanine
c. tryptophan
d. valine
e. isoleucine

119. One of the following is diamino monocarboxylic acid:

a. glutamine
b. proline
c. lysine
d. asparagine
e. glycine

120. INCORRECT about Phospholipase A2

a. site of action is small intestine


b. precursor of arachidonic acid
c. site of action is capillary wall
d. inhibited by steroids
e. activated by vasopressin

121. Which of the following amino acids tastes bitter?

a. Serine
b. Isoleucine
c. Leucine
d. Lysine

122. Normal Iron binding capacity:

a. 70-150 g/dl
b. 50-100 g/dl
c. 250-400 g/dl
d. 100-150 g/dl

123. Which of the following RNAs is generally degraded quickly?

a. tRNA
b. rRNA
c. SnRNA
d. mRNA
e. miRNA

124. Which of the following codon codes for proline?

a. UCA
b. UAG
c. CCA
d. UAA
e. UCU

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125. Which of the following enzymes is NOT involved in the pyrimidine biosynthesis?

a. carbamoyl phosphate synthetase-II


b. aspartyl transcarbamoylase
c. dihydro orotate dehydrogenase
d. carbamoyl phosphate synthetase-I
e. orotate phosphoribosyl transferase

126. RNA involved in splicing function:

a. Small Nuclear RNAs (SnRNAs)


b. Micro-RNA (miRNA)
c. Ribosomal RNA (rRNA)
d. Transfer RNA (tRNA)
e. Messenger RNA (mRNA)

127. All of the following factors reduces iron absorption EXCEPT:

a. copper
b. phosphates
c. milk
d. oxalic acid
e. ascorbic acid

128. Which of the following fatty acids contain NO double bond?

a. stearic acid
b. nervonic acid
c. cervonic acid
d. oleic acid

129. The number of haploid set of chromosome in Chimpanzee is

a. 26
b. 23
c. 24
d. 22
e. 21

130. Spot the WRONG statement about dicot roots:

a. pith is absent
b. xylem is tetrarch
c. metaxylem vessels are generally circular
d. characterized by secondary growth
e. conjunctive tissue is usually parenchymatous

131. Acetoacetate:

a. synthesized by the liver mitochondria


b. is synthesized from Beta-hydroxy butyrate
c. brain cannot utilize acetoacetate
d. produced from transmination of tryptophan

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132. INCORRECT regarding monocot stem:

a. starch sheath is absent


b. absence of pith
c. bundle sheath is present
d. pericycle is present
e. hypodermis made of sclerenchymatous cells

133. All of the following are mucopolysaccharides EXCEPT:

a. amylopectin
b. chondroitin sulfate
c. hyaluronic acid
d. heparin

134. Many bacteria synthesize the vitamin Folic acid from-

a. tetrahydrofolic acid
b. tetrahydrofolate
c. hippuric acid
d. para-aminobenzoic acid
e. thymidylic acid

135. The final step in glycolysis is catalyzed by the enzyme:

a. enolase
b. phosphoglycerate kinase
c. hexokinase
d. pyruvate kinase
e. aldolase

136. Who first put forward the theory of enzyme catalysis?

a. Ostwald
b. Berzelius
c. Willy Kunhe
d. Edward Buchner
e. James Sumner

137. The iron content of muscle myoglobin is:

a. 2600 mg
b. 200 mg
c. 600 mg
d. 20 mg

138. Activation of fatty acids to fatty acyl CoA is catalyzed by the enzyme:

a. Phosphorylase kinase
b. Pyruvate kinase
c. Thiokinase
d. Glycerol kinase
e. Phosphofructokinase

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139. Cholecystokinin (CCK):

a. has 36 amino acids


b. secreted by gallbladder
c. secreted by C cells of duodenum
d. glycoprotein hormone
e. it increases appetite

140. Glutathione is synthesized from

a. glutamic acid, cysteine, serine


b. arginine, glycine, glutamic acid
c. glutamic acid, histidine, glycine
d. glutamic acid, cysteine, glycine
e. aspartate, cysteine, lysine

141. ATP generated by oxidation of acetyl CoA:

a. 10
b. 38
c. 3
d. 12
e. 32

142. Which of the following best fits a 'primary transcript'?

a. sRNA
b. mRNA
c. SnRNA
d. tRNA
e. rRNA

143. Which of the following a nonessential amino acid?

a. methionine
b. lysine
c. phenylalanine
d. threonine
e. tyrosine

144. CORRECT about Citric acid cycle:

a. ADP activates isocitrate dehydrogenase


b. malonate inhibits alpha-ketoglutarate dehydrogenase
c. ATP inhibits citrate synthase
d. fluoroacetate inhibits aconitase
e. high NADH suppresses the rate of citric acid cycle

145. Chymotrypsin has _____ polypetide chains and _____ number of amino acids.

a. 3z241
b. 3z471
c. 4z574
d. 1z165
e. 2z800

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146. Regarding the distribution of Cholesterol in human body, mark the CORRECT statement:

a. liver and spleen z 5 gm


b. bone marrow z10 gm
c. brain z 40 gm
d. muscles z40 gm
e. blood z10 gm

147. The term Chromosome was introduced by:

a. Bridges
b. Balbiani
c. Flemming
d. Waldeyer
e. Mendel

148. What is correct regarding transcription?

a. rRNA is involved in transcription into mRNA


b. DNA is transcribed into mRNA by tRNA
c. message is copied from the sense strand of the DNA
d. message is copied from the coding strand of the DNA

149. The 'stop' codon (nonsense codon) is:

a. UGG
b. CUA
c. AUG
d. UCU
e. UGA

150. A WRONG match about one letter abbreviation of amino acids:

a. HistidinezD
b. PhenylalaninezF
c. LysinezK
d. GlycinezQ
e. AsparaginezN

151. Which of the following vitamins is protective against ischemic heart disease (IHD) in patients with high blood
homocysteine level?

a. pyridoxine
b. biotin
c. niacin
d. folic acid
e. thiamin

152. Histones:

a. histone synthesis starts when DNA synthesis ceases


b. are synthesized in the nucleus
c. are rich in hydroxyproline
d. contain a high conc. basic amino acids
e. contain a high conc. acidic amino acids

Page 21
153. Least saturated:

a. cotton seed oil


b. ground nut oil
c. seasame oil
d. coconut oil
e. palm oil

154. Which of the following enzymes belongs to Transferases?

a. Aldolase
b. Lactate dehydrogenase
c. Hexokinase
d. Acetyl CoA carboxylase

155. Which of the following has the highest iron content in mg/100 gm?

a. Radish
b. Amaranth
c. Bengal gram
d. Gram leaves
e. Soyabean

156. All of the following are Pyrimidine Bases EXCEPT:

a. thymine
b. cytosine
c. guanine
d. uracil

157. The site of action of lipoprotein lipase is:

a. adipocytes
b. small intestine
c. stomach
d. mouth
e. capillary wall

158. Regarding cortical cells (cortex) of plants:

a. consists of only sclerenchyma cells


b. absence of leucoplasts
c. store starch grain
d. contain chloroplast
e. outermost layer is endodermis

159. Reduction of Galactose results in:

a. Inositol
b. Sorbitol
c. Dulcitol
d. Ribitol
e. Mannitol

Page 22
160. Which among the following is NOT a pancreatic enzyme?

a. Pancreozymin
b. DNase I
c. Chymotrypsin
d. Amylase
e. Trypsin

161. 2, 6-di-oxopurine:

a. xanthine
b. hypoxanthine
c. adenine
d. guanine
e. uric acid

162. Insulin represses the following enzymes EXCEPT:

a. Glucose-6-phosphatase
b. Phospho enol pyruvate carboxy kinase
c. Phospho fructo kinase
d. Fructose-1,6-bisphosphatase

163. The most common monosaccharides in nature:

a. D-fructose
b. D-galactose
c. 2-deoxy-D-ribose
d. L-arabinose
e. D-ribose

164. Among the HACEK group of bacterial species, which one is least/rarely associated with endocarditis?

a. Hemophilus aphrophilus
b. Eikenella corrodens
c. Actinobacillus actinomycetemcomitans
d. Cardiobacterium hominis
e. Kingella kingae

165. A metallo-enzyme that contains iron:

a. Tyrosinase
b. Superoxide dismutase
c. Cytochrome oxidase
d. Lysyl oxidase
e. Carbonic anhydrase

166. Which of the following is a NADP+ linked dehydrogenase?

a. Pyruvate dehydrogenase
b. Glycerolphosphate dehydrogenase
c. glucose-6-phosphate dehydrogenase
d. Glyceraldehyde-3-phosphate dehydrogenase
e. Succinate dehydrogenase

Page 23
167. The most common environmental poison in India is:

a. Mercury
b. Arsenic
c. Aluminium
d. Lead

168. All of the following are involved in the biosynthesis of acetoacetate EXCEPT:

a. Acetoacetyl CoA
b. Hydroxymethyl glutaryl CoA
c. Acetone
d. Acetyl CoA

169. Which of the following is NOT a Glycosphingolipid?

a. Cerebrosides
b. Sphingomyelin
c. Globosides
d. Gangliosides

170. Which of the following is Niacin?

a. dihydroxy dimethyl butyric acid


b. 3-hydroxy anthranilic acid
c. hippuric acid
d. hexuronic acid
e. pyridine 3-carboxylic acid

171. All of the following are FAD-linked dehydrogenase EXCEPT:

a. Succinate dehydrogenase
b. Malate dehydrogenase
c. Glycerolphosphate dehydrogenase
d. Fatty acyl CoA dehydrogenase

172. Glucocorticoids are secreted from ____ of adrenal gland.

a. zona reticularis
b. zona glomerulosa
c. medulla
d. zona fasciculata

173. Which of the following inhibits enzyme Glucokinase?

a. insulin
b. glucose
c. fructose-2, 6-bisphosphate
d. fructose-6-phosphate

174. Glutamine is produced from

a. glutamate semialdehyde
b. -ketoglutarate
c. oxaloacetate
d. glutamate

Page 24
175. Which of the following fatty acids contain two (2) double bonds?

a. Oleic acid
b. Linoleic acid
c. Arachidonic acid
d. Linolenic acid

176. Which of the following amino acids contains a Indole group?

a. Histidine
b. Arginine
c. Tryptophan
d. Proline

177. A marker enzyme for peroxisomes:

a. phospholipase
b. catalase
c. isomerase
d. peroxidase

178. The first step in glycolysis is catalyzed by the enzyme:

a. pyruvate kinase
b. hexokinase
c. aldolase
d. enolase
e. phosphoglycerate kinase

179. Oxalic acid can be produced from oxidation of which of the following compounds?

a. Ethylene glycol
b. Aspartate
c. Oxaloacetate
d. Methanol
e. Para-nitrophenol

180. Which of the following statements about brain metabolism is INCORRECT?

a. brain metabolizes 60% of total carbohydrate intake


b. Pasteur effect protects brain aginst anoxia
c. brain utilizes ketone bodies during starvation
d. brain can effectively utilize fatty acids

181. All of the following are nonessential aminoacids EXCEPT:

a. aspartic acid
b. leucine
c. cysteine
d. alanine
e. serine

182. All of the following are Stop Codons EXCEPT:

a. AUG
b. UAG
c. UGA
d. UAA

Page 25
183. In patients with Alkaptonuria, there is a deficiency or abnormality of which enzyme?

a. Homogentisic acid oxidase


b. Branched chain keto acid decarboxylase
c. Ornithine decarboxylase
d. Cystathionine beta synthase
e. Xanthine oxidase

184. Pellagra occurs due to the deficiency of:

a. pyridoxine
b. biotin
c. niacin
d. thiamin
e. folic acid

185. Which of the following contains highest amount of saturated fatty acids?

a. Pig Lard
b. Mustard (rapeseed) oil
c. Ox Tallow
d. Palm oil

186. A calcium containing enzyme:

a. Xanthine oxidase
b. Enolase
c. Tyrosinase
d. Lecithinase

187. Which of the following has the highest Calcium content among the given?

a. Beetroot
b. Drumstick leaves
c. Watermelon
d. Soyabean
e. Radish

188. Which of the following amino acids has an imidazole ring?

a. tyrosine
b. arginine
c. phenyl alanine
d. histidine
e. asparagine

189. An example of Pentose:

a. Ribulose
b. Dihydroxyacetone
c. Erythrose
d. Glyceraldehyde
e. Mannose

Page 26
190. INCORRECT about hormonal regulation of glycogen metabolism:

a. epinephrine increases AMP


b. phosphodiesterases do not favor glycogenolysis
c. insulin stimulates glycogenesis
d. glucagon increases cAMP
e. adrenaline stimulates glycogenolysis

191. Which of the following is an intermediate of uronic acid pathway?

a. Xylulose
b. Ribose
c. O-glucuronide
d. Hexuronic acid
e. Ribulose

192. A metallo-enzyme that contains copper:

a. Xanthine oxidase
b. Catalase
c. Lecithinase
d. Tyrosinase
e. Peroxidase

193. Which of the following alters the function of mRNA?

a. rRNA
b. tRNA
c. miRNA
d. SnRNA

194. Complete oxidation of 1 mol of palmitate via -oxidation produces

a. 147 mol of ATP


b. 129 mol of ATP
c. 133 mol of ATP
d. 121 mol of ATP

195. Which of the following enzymes catalyzes the second step of beta-oxidation cycle?

a. acyl-CoA acetyltransferase
b. Beta-hydroxyacyl-CoA dehydrogenase
c. enoyl-CoA hydratase
d. 3-Hydroxybutyrate dehydrogenase
e. acyl-CoA dehydrogenase

196. INCORRECT about Creatinine:

a. is formed from urea


b. total body creatinine is proportional to muscle mass
c. is synthesized from arginine
d. normal blood level is 0.7-1.4 mg/dL
e. is formed from creatine

197. The activator of Pyruvate carboxylase is:

a. insulin
b. glucose
c. Acetyl CoA
d. AMP

Page 27
198. INCORRECT about Benedict's test:

a. green color indicates absence of glucose in urine


b. yellow precipitate indicates 1% of sugar
c. orange precipitate indicates 1.5% of sugar
d. formation of precipitate on cooling
e. red precipitate indicates 2% of sugar

199. Phosphofructokinase 1

a. inhibited by ATP
b. inhibited by AMP
c. inhibited by fructose-2,6-bisphosphate
d. decreased in fed state

200. A WRONG match about one letter abbreviation of amino acids:

a. Asparagine zN
b. GlycinezQ
c. Glutamic acidzE
d. Tryoptophan zY
e. Lysine zK

Page 28
Form a BIOCHEMISTRY AND CELL BIOLOGY
BASIC SCIENCE
Single Option Multiple Choice Questions.
Choose the most appropriate/correct answer.
Thereis no negative marking for Wrong answer.
ANSWERS

1 c
2 c
3 d
4 c
5 b
6 e
7 b
8 c
9 a
10 a
11 b
12 d
13 b
14 c
15 b
16 a
17 d
18 a
19 c
20 e
21 c
22 c
23 c
24 b
25 b
26 c
27 e
28 b
29 d
30 e
31 e
32 c
33 d
34 d
35 a
36 e
37 a
38 c
39 e
40 b
41 d
42 c
43 a
44 c
45 a
46 d
47 a
48 c
49 d
50 b
51 a
52 c
53 d
54 b
55 a
56 b
57 a
58 b
59 d
60 b
61 e
62 a
63 d
64 b
65 e
66 d
67 a
68 a
Page 1
69 a
70 c
71 e
72 e
73 e
74 a
75 d
76 d
77 b
78 a
79 e
80 d
81 c
82 c
83 b
84 d
85 d
86 a
87 a
88 d
89 a
90 b
91 b
92 e
93 a
94 e
95 d
96 b
97 b
98 b
99 d
100 e
101 d
102 a
103 a
104 a
105 e
106 a
107 c
108 b
109 d
110 a
111 b
112 d
113 e
114 c
115 a
116 e
117 e
118 a
119 c
120 c
121 b
122 c
123 d
124 c
125 d
126 a
127 e
128 a
129 c
130 c
131 a
132 d
133 a
134 d
135 d
136 b
137 b

Page 2
138 c
139 c
140 d
141 a
142 b
143 e
144 b
145 a
146 e
147 d
148 c
149 e
150 a
151 d
152 d
153 c
154 c
155 d
156 c
157 e
158 c
159 c
160 a
161 a
162 c
163 a
164 e
165 c
166 c
167 d
168 c
169 b
170 e
171 b
172 d
173 d
174 d
175 b
176 c
177 b
178 b
179 a
180 d
181 b
182 a
183 a
184 c
185 c
186 d
187 b
188 d
189 a
190 a
191 a
192 d
193 c
194 b
195 c
196 a
197 c
198 a
199 a
200 d

Page 3