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90 ~ 98 2009/8/18 v.

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Content
 Amino Acid Metabolism
 Nucleotide Metabolism and amino acid derived molecules
 Others

Amino Acid Metabolism


1. hypercatabolic stateurea nitrogen (981-2101)
(a) protein degradation (b) urea nitrogen amino acid (c) amino acid urea cycle
urea (d) urea cycle kidney

2. Inorganic nitrogenOrganic molecule(981-


2101)
(a) Arginase (b) Glutamate dehydrogenase (c) Glutamine synthetase (d) Nitrogenase

3. Alkaptonuria (981-2101)
(a) Branched-chain -keto acid dehydrogenase complex
(b) Homogentisic acid dioxygenase
(c) Alanine transaminase
(d) Glutamine amidotransferase

4. phenylketonuria(982-2101)
(a) Phenylalanine (b) Phenylpyruvate (c) Para-hydroxyphenylpyruvate (d) Phenylacetate

5. 1
ammonia (982-2101)
(a) (b)
(c) urea cycle
(d) blood-brain barrier

6. fumarate (982-2101)
(a) Phenylalanine (b) Alanine (c) Cysteine (d) Serine

7. (982-2101)
(a) Leukotriene (b) Testosterone (c) Insulin (d) Prostaglandin

8. Urea cycle enzyme deficiency amino acid urea cycle(972-2101)


(a) phenylalanine (b) arginine (c) citrulline (d) ornithine

9. ureaNH4+CO2 ammonia
carbamoyl phosphate synthetase I (971-2101)
(a) (b) ATP
(c) HCO3 NH4+(d) carbamoyl phosphate
-

10. Phenylketonuria (971-2101)


(a) Branched-chain -keto acid dehydrogenase complex
(b) Homogentisic acid dioxygenase
(c) Tyrosinase
(d) Phenylalanine hydroxylase
11. ammonia ammonia
ammonia (971-2101)
(a) leucine (b) pyruvate (c) glutamate (d) -ketoglutarate

12. (pepsin) (941-2101)


A (HCl) B (trypsin)
C (enteropeptidase) D (amylase)

13. ammonia liver Urea cycle


(951-2101)
(a) alanine (b) glycine (c) serine (d) cysteine

14. alanine transaminase glutamate: pyruvate transaminase


(942-5217)
(a)-ketoglutarate serine threonine (d) histidine

15. amino group (931-5217)


(A) glycine (B) glutamine(C) asparagine (D) aspartic acid

16. transaminationcoenzyme(90-301)
(a) (riboflavin) (b) (thiamin) (c) (vitamin) B6 (d) B12

17. transaminase (deamination) coenzyme(931-2101)


(a) A (coenzyme A) (b) (biotin) (c) (pyridoxal phosphate) (d)
(thiamine)

18. Alanine 2-oxoglutarate alanine aminotransferase glutamate (961-2101)


(a) aspartate (b) oxaloacetate (c) ketobutyrate (D) pyruvate

19. Aspartate transaminase Glutamate:oxaloacetate transaminase C


(961-2101)
(a) pyridoxal phosphate (b) thiamine (c) FAD (D) ATP

20. GPT GOT (91-3101)


Aaminotransferase Btransketolase
C glycolysis D

21. (932-2101)
(a) Ala (b) Asp (c) Glu (d) Ser

22. Urea cycle Urea NH4+ , (932-5217)


(A) Methionine (B) Aspartate (C) Glycine (D)Arginine

23. ? (931-2101)
(a) ammonia (b) urea (c) glutamine (d) uric acid
p.s. Ans = B

24. NH4+(921-5217)
(a) Histidine (b) Arginine (c) Glutamine (d) Asparagine

25. (urea) (912-5217)


(a) ornithine transcarbamylase (b) arginase (c) glutaminase (d) phenylalanine hydroxylase
26. carbamoyl phosphate synthetase I allosteric activator(922-2101)
AN-acetylglutamate BCitrulline CGlutamine DAspartate
27. (941-2101)
Aurea nitrogen B3-hydroxybutyrate Cfree fatty acid Dalanine

28. TCA (932-2101)


AAlanine, aspartate, glutamate BGlycine, serine, cysteine
CTyrosine, phenylalanine, tryptophan DArginine, lysine, histidine

29. Leucineisoleucine valine


(921-5217)
(a) Alanine aminotransferase (b) Aspartate aminotransferase
(c) Branch-chain aminotransferase (d) Methylmalonyl aminotransferase

30. (albinism) (941-2101)


Aarginosuccinase Bphenylalanine hydroxylase
Cmethylmalonyl CoA mutase Dtyrosinase

31. phenylalanine hydroxylase (921-2101)


(a) sucrose (b) fructose (c) maltose (d) aspartame

32. Maple syrup urine disease (942-5217)


(a) branched-chain -keto acid dehydrogenase complex
(b) homogentisic acid dioxygenase
(c) tyrosinase
(d) phenylalanine hydroxylase

33. Aspartate-argininosuccinate shunt (931-5217)


(A) (B)
(C) (D )

34. N2 nitrogen fixation ammonia(952-2101)


(A) nitrate reductase, nitrite reductase
(B) glutamate synthase, glutamate dehydrogenase
(C) dihydrofolate reductase, methione synthase
(D) nitrogenase, nitrogenase reductase

35. N2 (932-5217)
(A) arginase (B) glutamate synthase
(C) glutamine synthetase (D) nitrogenase

36. non-essential amino acidKrebs cycle


(901-015)
(a) (proline) (b) (methionine) (c) (glycine) (d) (tyrosine)

37. CO2 carboxylationcoenzyme(931-5217)


(A) lipoic acid (B) thiamine (C) biotin (D) Acoenzyme A

38. ? (901-015)
(a) Glycine (b) Alanine (c) Tyrosine (d) Lysine

39. cysteine(902-015)
(a) threonine (b) lysine (c) methionine (d) tryptophan

40. B1(92-5217)
(a) lipoic acid (b) pyridoxal phosphate (c) coenzyme A (d) thiamine pyrophosphate
41. B12 : (941-2101)
Aacetyl CoA carboxylase Bpyruvate dehydrogenase
Cmethionine synthase Dxanthine oxidase

42. aromatic(942-5217)
(a) lactate (b) shikimate (c) benzoic acid (d) -ketoglutarate

43. histidine (921-5217)


(a) UTP (b) TTP (c) ATP (d) GTP

44. glutamine synthetase ? (931-2101)


(a) ATP (b) -ketoglutarate
(c) PII protein uridylylation (d) Glutamine synthetase deadenylylation

Nucleotide Metabolism and amino acid derived molecules


45. methyl donor(972-2101)
(a) valine (b) threonine (c) methionine (d) glutamine

46. NO(972-2101)
(a) Arginine (b) Tryptophan (c) Lysine (d) Methionine

47. Methotrexate (971-2101)


(a) pyridoxal phosphate
(b) dihydrofolate reductase
(c) EPSP synthase
(d) glycolysis

48. one-carbon groupsDNA (971-2101)


(a) coenzyme A (b) lipoate (c) tetrahydrofolate (d) pyridoxal phosphate

49. DNA RNA (961-2101)


(A) (B)
(C) (D) -OH

50. Indole-3-acetic acid (952-2101)


(A) Arginine (B) Histidine (C) Tryptophan (D) Phenylalanine

51. salvage pathway(952-2101)


(A)
(B) de novo pathway ATP
(C) adenosine kinase salvage pathway
(D) salvage pathway Inosine 5-monophosphate hypoxanthine

52. citric acid cyclemetaboliteporphyrin


precursor(952-2101)
(A) oxaloacetate (B) alpha-ketoglutarate (C) citrate (D) succinyl CoA

53. Lesch-Nyhan syndrome (951-2101)


(a) Hypoxanthine (b) Inosine 5-hypoxanthine (c) Guanosine 5-monophosphate (d) ATP
54. ribonucleic acid, RNA(952-2101)
(A) 2'hydroxy group, -OH
(B) tRNA
(C) RNA A G U C
(D) RNA A U G C

55. coenzyme adenosine (932-5217)



(A) NAD (B) FAD (C) activativated methionine (D) cGMP

56. Melatonin 5-Serotonin


(932-5217)
(A) Tryptophan (B) Tyrosine
(C) Phenylalanine (D) Histidine

57. nucleoside monophosphate kinase AMP  ADP  ATP


(931-2101)
(a) (b) AMP (c) ATP (d) UDP

58. bilirubin glucuronic acid conjugation(911-5217)


(a) (b) (c) (d)

59. Aspirin (921-2101)


Asubstance P Bhistamine Cbradykinin D5-HT

60. (hemoglobin) ? (901-015)


(a) (dopamine) (b) (serotonin) (c) (epinephrine)
(b) - (GABA)

61. (NOS) NO? (901-015)


(a) L-arginine (b) L-citrulline (c) Spermidine (d) Spermine

62. RNA ? (1) adenine (2) guanine (3) cytosine (4) thymine (5) uracil (931-2101)
(a) 1,2,3,4 (b) 1,2,3,5 (C) 1,2,4,5 (d) 1,3,4,5

63. (pyrimidine) ? (901-015)


(a) Glutamine NH3 (b) Carbamoyl phosphate glutamate
(c) Aspartate carbamoyl phosphate (d) Glutamine glutamate

64. ? (901-015)
(a) Dopa (b) Dopamine (c) Norepinephrine (d) Epinephrine

65. salvage pathway ? (931-2101)


(a) Severe combined immunodeficiency disease (b) Xeroderma pigmentosum
(c) Balloon syndrome (d) Lesch-Nyhan syndrome

66. Glutathione antioxidant


(912-5217)
(a) histidine (b) glutamate (c) cysteine(d) glycine

67. glutathione(911-5217)
(a)
(b) free radicals
(c) hemoglobinmethemoglobin
(d) sulfur conjugates
68. serotonin (921-5217)
A His BPhe CTrp DTyr

69. nitric oxide (921-5217)


A Arg BGly CHis DLys

70. creatine (921-5217)


A GluAla BArgAla CLysGly DArgGly

71. thyroxine (921-2101)


Athreonine Btyrosine Cthiamine Dtryptophan

72. TyrosinePrecursorNeurotransmitter(922-2101)
(a) -GABA BDopamine
(b) Serotonin DAcetylcholine

73. porphyrin(912-5217)
Aleucine Bproline Calanine Dglycine
74. phenylalaninetyrosine(901-015)
(a) (thyroxine) (b) (dopamine) (c) (epinephrine) (d) (corticoid)

75. pantothenic acid (921-5217)


A Decarboxylation BOxidation CAcetylation DPhosphorylation

76. human immunodeficiency virusHIV AZT (901-015)


AAZT infected cell AZT AZT triphosphate
BAZT DNA DNA polymerasehigher affinity
CAZT reverse transcriptase
DAZT

77. hypoxanthineaminopterinthymidine
(901-015)
Aacquired immune deficiency syndrome BLesch-Nyhan
Csevere combined immune deficiency syndrome Dgout

78. (5-fluorouracil) , ? (901-015)


(a) Dihydrofolate reductase (b) Tetrahydrofolate reductase
(C) Thymidylate synthase (D) Ribonucleotide reductase

79. De Novopurine nucleotide(922-2101)


A1-D-ribosyl 1-phosphate B5-D-ribosyl 5-phosphate
C5--1-5-phosphorylribosyl-1-pyrophosphate
D5-D-ribulosyl-5-phosphate

80. ribose 5-phosphate nucleotide nucleic acid ribose


(902-015)
A glycolysis Bgluconeogenesis
Cpentose phosphate pathway
Dpyrimidine nucleotide synthesis

81. AMP de novo synthesis (932-2101)


(a) Asp (b) Val (c) CO2 (d) Gln

82. pyrimidine ring(921-2101)


A B Caspartic acid DNH3
83. deoxyribose(92-5217)

AUridine BDNA CFAD DNAD

84. uric acidgout(911) [H1]: Insoluble end product from


A alanine Bcysteine CUTP DAMP purine degradation

85. Allopurinol (901-015)


A xanthine oxidase
B hypoxanthine phosphoribosyl transferaseHPRT
C dihydrofolate reductase
D thymidylate synthetase

86. gout(91-3101)
A pyrimidine B sodium urate C urea
D pH

87. (961-2101)
AAspirin
B Colchicine
C Probenecid
DAllopurinol superoxide dismutase

88. 5-fluorouracil (961-2101)


A DNA DNA
B dihydrofolic acid
C thymidylate synthase
D DNA polymerase

89. fluorouracil5-FU(912-5217)
Apurine B G2
C D 5-FdUMP

90. 5-fluorourcil5-FU(901-015)
Axanthine oxidase
Bhypoxanthine phosphoribosyl transferaseHPRT
Cdihydrofolate reductase
Dthymidylate synthetase

91. AZT HIV thymidine deoxyribose ? (932-


2101)
(a) 2 N2 group (b) 2 N3 group
(c) 3 N2 group (d) 3 N3 group

92. dATP
immunodeficiency(911-5217)
A adenine phosphoribysl transferase Bxanthine oxidase Cadenosine deaminase Dpurine
nucleoside phosphorylase
[H2]: Converts adenosine to
inosine. Enzyme deficiency cause
93. Purine (91-3101) dATP accumulates, which is an
APRPP synthase BHGPRTase CAdenosine deaminase DXanthine oxidase inhibitor of ribonucleotide reductase.
High levels of dATP produce a general
deficiency of other dNTPs in T
lymphocytes.
94. -aminoisobutyrate succinyl [H3]: Soluble end products from
CoA TCA cycle(912-5217) pyrimidine degradation.
Aadenine Bguanine Ccytosine Dthymine [H4]: Degraded to -alanine.

95. biotin(912-5217)
A acetate BCO2 Cmethanol Dphosphate

96. (ribose)(941-2101)
ACoA BNAD CFAD Dthiamine pyrophosphate

97. GTP (glycosidic bond) (941-2101)


AC5-N1 BC1-N9 CC5-N9 DC1-N1

98. (tetrahydrofolate) (941-2101)


AN5, S10 BN5, N10 CN3, S7 DN3, N7

Others
99. ATP (952-2101)
(A) creatine phosphate ADP
(B) oxidative phosphorylation
(C) glycolysis
(D) myosin

100. , () ATP? (90D1= 901-


015)
(a) glycogen CO2 (b) glycogen lactate
(c) glycogen CO2 (d) fatty acids CO2

101. (901-015)
Aglucose Btriacylglycerol C
glycogen D

102. ketoacidosisketone
bodies(911-5217)
A glycolysis
B triacylglyceride
C fatty acids
D gluconeogenesis

103. enzymeglucoselactose
glycolysis(901-015)
Aphosphoglucoisomerase Bphosphofructokinase-1 Cenolase D3-phosphoglycerase kinase

104. ? (901-015)
(a) Avidin (b) Biotin (c) Niacin (d) Thiamin

105. ? (901-015)
(a) Ascobic acid (b) Vitamin A (c) Vitamin E (d) Vitamin K

106. CO2 carboxylationcoenzyme(931-5217)


(A) lipoic acid (B) thiamine (C) biotin (D) Acoenzyme A
107. second messenger(931-5217)

(A) Ca (B) CAMP (C) IP3 (D) Cprotein
kinase C

108. G-(932-5217)
(A) GTP (D) GDP
(C) GTP (D) 7 transmembrane domains

109. 100 4 (951-2101)


(a) anaerobic metabolism of glucose (b) aerobic metabolism of glucose
(c) creatine phosphate (d) ketone bodies