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TEGO Cosmo C 250

Brightens the complexion.

TEGO Cosmo C 250 is a pure skin identical amino acid derivate, which
reduces yellow skin tone and shows proven skin brightening properties.

Evonik delivers:
1. Reduction of yellow skin tone
2. Brightening of the skin
3. Skin identical amino acid derivate
Benefits Applications

Reduces yellow skin tone Color control fluid

Brightens the skin Skin brightening cream
Safely interferes in the transfer of melanin Anti-ageing products for even skin tone


TEGO Cosmo C 250 is a pure amino acid derivate

occurring naturally in the body
Easy to formulate
Pure white crystals
Recommended use level: 0.1 2.0%
INCI: 1-Methylhydantoin-2-Imide

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Hypothesis on the working mechanism of TEGO Cosmo C 250

TEGO Cosmo C 250 safely interferes in the transfer of melanin from melanocytes to keratinocytes.

Transfer inhibition of melanin from

melanocytes to keratinocytes

Evonik Industries AG | TEGO Cosmo C 250 | June 2014Page 3/8

TEGO Cosmo C 250 provides skin brightening
Facial study on Asian skin.

After 8 weeks

Vehicle TEGO Cosmo C 250 Positive control

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TEGO Cosmo C 250 provides skin brightening and reduces the yellow skin tone
Facial study on Asian skin.

Reduction of skin yellowness (chromameter b*) Increase in skin lightening (image analysis)
relative to vehicle [%] relative to vehicle [%]

0 5.0

-0.5 4.0

-1.0 3.0

-1.5 2.0

-2.0 1.0

-2.5 0
after 4 weeks after 8 weeks after 4 weeks after 8 weeks

TEGO Cosmo C 250 Positive control TEGO Cosmo C 250 Positive control

Evonik Industries AG | TEGO Cosmo C 250 | June 2014Page 5/8

Guideline formulation

O/W Cream with brightening effect (MM 13/2)

A TEGIN 4100 Pellets (Glyceryl Stearate) 2.5%

TEGO Alkanol 18 (Stearyl Alcohol) 1.0% 1. Heat phase A und B separately to approx. 80C.
2. Add phase A to phase B with stirring.1)
TEGOSOFT CT (Caprylic/Capric Triglyceride) 6.5%
3. Homogenise.
TEGOSOFT liquid (Cetearyl Ethylhexanoate) 6.0% 4. Cool with gentle stirring to approx. 60C and add
TEGOSOFT DC (Decyl Cocoate) 5.0% phase C.
Avocado (Persea Gratissima) Oil 3.0% 5. Homogenise for a short time.
6. Cool with gentle stirring and add phase D/E
B TEGO Care CG 90 (Cetearyl Glucoside) 1.0%
below 40C.
Glycerin 3.0%

Water 60.5% 1)
Important: If phase A has to be charged into the vessel
C TEGO Carbomer 134 (Carbomer) 0.2% first, phase B must be added without stirring.

Mineral Oil 0.8%

D TEGO Cosmo C 250 (1-Methylhydantoin-2-Imide) 1.0%

Water 9.0%

E Sodium Hydroxide (10% in water) 0.5%

Z Preservative, Perfume q.s.

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Evonik Industries AG | TEGO Cosmo C 250 | June 2014Page 7/8
Europe This information and all further technical advice is based on our present
France phone +33 237 82-7193 knowledge and experience. However, it implies no liability or other legal
Italy phone +39 0348 3363-778 responsibility on our part, including with regard to existing third party
Russia phone +7 495 721 2862 ext. 577 intellectual property rights, especially patent rights. In particular, no war-
Scandinavia phone +45 449 91-800 ranty, whether express or implied, or guarantee of product properties in
Spain phone +34 93 3458-822 the legal sense is intended or implied. We reserve the right to make any
United Kingdom phone +44 78 02791748 changes according to technological progress or further developments. The
customer is not released from the obligation to conduct careful inspection
Asia and testing of incoming goods. Performance of the product described
China phone +86 21 6119-3001 herein should be verified by testing, which should be carried out only by
India phone +91 22 6723-8891 qualified experts in the sole responsibility of a customer. Reference to trade
Indonesia phone +62 21 882-8322 names used by other companies is neither a recommendation, nor does it
Japan phone +81 3 5323-7384 imply that similar products could not be used.
South Korea phone +82 2 320-4784 For more detailed information or to obtain a brochure which addresses
a specific area of interest, please contact the Head Office of Evonik
The Americas Industries AG in Essen or contact your local representative.
Canada phone +1 416 704-1502
Brazil phone +55 11 3146-4139 This product information is not intended to provide legal or regulatory
Mexico phone +52 55 5483-0973 advice about product uses or claims in any jurisdiction and should not be
USA phone +1 804 452-5616 relied upon for such guidance (especially in the United States, Canada,
and Mexico). Since global regulatory requirements differ, parties access-
Africa ing this information are solely responsible for determining whether the
South Africa phone +27 11 697-0724 products and/or claims comply with applicable local laws and regulations,
including but not limited to import and export regulations. Please contact
Australia your local Evonik representative for more product information. Evonik
Australia & New Zealand phone +61 3 8581 8414 assumes no liability for any use of our products that is not in compliance
with the requirements of the country of the user. This product is not
intended to be used as a drug.
June 2014

Evonik Industries AG
Personal Care
Goldschmidtstrae 100, 45127 Essen, Germany
p.o. Box, 45116 Essen
phone +49 201 173-2854, fax +49 201 173-712854

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