-iptyline, -ipramine, doxepin, amoxapine

"dry as a bone, red as a beet, mad as a hatter, hot as a hare, blind as a bat"
"Vancomycin, can be prevented by infusion
"Wearing off" and "on-off-phenomenon"
gluconeogenesis, peripheral glucose uptake; increase insulin sensitivity
100% O2 and hyperbaric O2
5-fluorouracil (5-FU)
5HT2
Abciximab, tirofiban and eptifibatide
Acarbose, miglitol
ACE inhibitors
ACE inhibitors
Acebutolol, betaxolol, esmolol, atenolol, metoprolol (A BEAM)
Acetazolamide
Acetazolamide
Acetazolamide
Acetylcholine, nicotine
Acid reflux disease, duodenal ulcer and peptic ulcer disease
Act on intestine, delay digestion and absorption of glucose
Activate mu receptors to 1. close presynaptic Ca2+ channels to inhibit
neurotransmitter release, 2. open postsynaptic K+ channels to hyperpolarize
cell membrane
Activate PPAR-gamma, transcription of insulin-responsive genes, GLUT4
glucose transporter, insulin sensitivity
Activates BZ1 subtype of GABAA receptor
Activates G-protein coupled K+ channels in atrium, SA and AV node
Acyclovir; activated by viral thymidine kinase, inhibits viral DNA replication
Adenosine
Adenosine
Administration of Vit B6 (pyridoxine)
Affinity
Albuterol
Alcohol, opioid, barbiturate/benzodiazepine
Alendronate and -dronates
Allopurinol
Allopurinol, febuxostat
Alpha 1 agonists
Alprostadil (PGE1)
Alprostadil (PGE1)
Alteplase
Amantadine
Aminocaproic acid
Aminoglutethimide
Amiodarone
Amiodarone
Amiodarone
Amoxicillin
Amrinone and milrinone
Anterograde amnesia
Anti-DUMBBELSS
Anti-inflammatory, analgesia, antipyretic and antiplatelet activity
Antipyretic and analgesic activity
Antithrombin 3
Anxiety, insomnia, alcohol detoxification, status epilepticus, spasticity
Aripiprazole
Arteries and veins
Aspart, lispro, glulisine
Aspirin
Aspirin
Aspirin
Asthma (bronchospastic effects), diabetes (block signs of hypoglycemia) and
peripheral vascular disease
at a slow rate and antihistamines"
Atracurium, cisatracurium
Atrial fibrillation and congestive heart failure
Atropine
Atropine, anti-muscarinics
Atropine, pralidoxime (2-PAM)
Autacoids
Autonomic (block muscarinic and 1), sedation
Azathioprine, 6-mercaptopurine
Azathioprine, 6-mercaptopurine, 6-thioguanine
Azithromycin or levofloxacin
Aztreonam
B-blockers
Benzodiazepines work only in presence of GABA
Benztropine
Benztropine
Benztropine, diphenhydramine
Beta -blockers
Beta 1 agonist
Beta blockers
Beta-blockers such as propranolol and esmolol
Betamethasone, dexamethasone
Bethanechol
Bevacizumab
Bile acid-binding resins
Binds D-Ala-D-Ala on murein monomers and prevent polymerization of the
murein monomers
Binds to ergosterol and creates a pore in fungal membrane
Bioavailability (F)
Bivalirudin, argatroban
Bleeding
Bleomycin
Bleomycin
Block AT1 receptors
Block cell wall synthesis by inhibiting transpeptidase and block
peptidoglycan cross-linkage
Block L-type calcium channels
Block NMDA receptor
Block serotonin and norepinephrine reuptake
Block voltage-gated sodium channels
Blocks sodium channels
Blocks sodium channels, T-type calcium channels, and increase GABA
concentration
Blocks T-type calcium channels
Blood:gas partition coefficient
Bradycardia, AV block, impotence, dyslipidemia, exacerbation of COPD
Bradykinin
Bradykinin and histamine
Brimonidine
Bromocriptine
Bromocriptine
Bupivacaine
Buprenorphine
Bupropion
Buspirone
Busulfan
Caffeine, nicotine, cocaine, amphetamines
Calcitonin (salmon prep)
Calcium
Calcium channel blockers
Carbamazepine
Carbamazepine
Carbamazepine
Carbamazepine, phenytoin, valproic acid
Carbidopa
Cardiovascular stimulation, increased cerebral blood flow, vivid dreams,
hallucinations
Carmustine, -mustines
Cartilage damage
Carvedilol
Ceftriaxone
Celecoxib
Cephalosporins
Cerebral hemorrhage
Chloramphenicol
Chlorpheniramine
Chlorpromazine, thioridazine
Chlorpropamide
Cholinesterase inhibitors
Cimetidine
Cinchonism
Cisplatin, carboplatin
Class IC (flecainide, propafenone)
Classic (exertional) angina
Clearance (CL)
Clindamycin
Clomiphene
Clomipramine
Clopidogrel and ticlopidine
Close K+ channels, depolarize cell, open voltage-gated Ca2+ channels,
release insulin
Close K+ channels, depolarize cell, open voltage-gated Ca2+ channels,
release insulin
Clozapine
Clozapine, olanzapine
CNS depression
CNS excitation
Cocaine
Cocaine
Codeine, hydrocodone, and oxycodone
Competitive antagonist
Constipation, peripheral edema, cardiac depression, AV block
Convulsion, cardiotoxicity, coma (3 C's)
Corrosive esophagitis, osteonecrosis of the jaw
Cosyntropin
COX 1: constitutive, COX 2: inducible during inflammation
Cp
Cutaneous flush
Cyanide poisoning
Cyanocobalamin (Vit B12)
Cyclophosphamide, ifosfamide
Cyproheptadine
Cyproterone
Cytarabine
Dactinomycin (actinomycin D)
Danazol
Dantrolene
Dantrolene
Dapsone
Daunorubicin, doxorubicin
Decreases protein synthesis by binding to 30S ribosome and prevent binding
of tRNA
Deferoxamine
Delirium tremens
demeclocycline
Desmopressin
Dexrazoxane
Dextromethorphan, Codeine
Diarrhea, liver toxicity, myelosuppression
Diazepam, chlordiazepoxide
Diazepam, lorazepam
Didanosine
Digibind
Dimenhydrinate
Dimercaprol, succimer
Diphenhydramine
Diphenhydramine
Diphenoxylate, Loperamide
Dipyridamole, cilostazol
Disulfiram
Disulfiram-like reaction
Disulfiram-like reactions with alcohol use
Dobutamine and dopamine
Donepezil, rivastigmine, galantamine
Doxepin
Drug-induced Parkinsonism
Dry cough
Dry cough, hyperkalemia, angioedema
Dry mouth (anticholinergic), sedation (antihistamine), hypotension (1 block)
Duloxetine, venlafaxine
DUMBELSS (diarrhea, urination, miosis, bronchoconstriction, excitation of
skeletal muscle and CNS, lacrimation, salivation, and sweating)
Dystonia, akathisia, bradykinesia, tardive dyskinesia (extrapyramidal
symptoms)
Early distal convoluted tubule
Echothiophate
ED50
Edetate calcium disodium, succimer, or dimercaprol
Edrophonium
Efavirenz, and ribavirin
Efficacy
Elderly with dementia-related psychosis
Enflurane
Entacapone, tolcapone
Ephedrine
Epinephrine
Epinephrine
Epoprostenol (PGI2)
Ergotamine
Erythropoietin
Esmolol
Esmolol
Ester-type (local anesthetic with one "I" in name)
Estrogen
Ethanol
Ethinyl estradiol and mestranol
Ethosuximide
Etidronate
Etoposide, teniposide
Exenatide, liraglutide
Ezetimibe
Fentanyl
Fentanyl
Fentanyl and droperidol
Ferrous sulfate
Fexofenadine, loratadine, and cetirizine
Filgrastim (granulocyte colony-stimulating factor) and sargramostim
(granulocyte-macrophage colony-stimulating factor)
Finasteride
First order kinetics
First pass effect
Flatulence , diarrhea, abdominal cramps
Fludrocortisone and deoxycorticosterone
Flumazenil
Flumazenil
Flunitrazepam, GHB (-hydroxybutyrate)
Fluoroquinolones (ciprofloxacin, levofloxacin), trimethoprim-
sulfamethoxazole
Fluoxetine, paroxetine, sertraline, citalopram
Flutamide
Folic acid
Fomepizole, ethanol
Fomepizole, ethanol
Full agonist
Gabapentin
Gallstone formation
Ganciclovir
Ganciclovir, zidovudine, interferon
Ganirelix
Gastric ulcers and GI Bleeding
Geriatrics due to its CNS (depression) effects
GI bleeding
GI tract, vomiting center of medulla
Gingival hyperplasia, nystagmus, diplopia and ataxia
Glargine, detemir
Glucagon
Glucocorticoids
Glucuronidation, acetylation, glutathione conjugation, glycine conjugation,
sulfation, methylation, water conjugation
Glyburide, glipizide, glimepiride
Gynecomastia
Gynecomastia hyperkalemia, and impotence
Half-life (T1/2)
Haloperidol
Haloperidol
Haloperidol, fluphenazine, trifluoperazine
Halothane
Heart failure
Hemorrhagic cystitis
Heparin
Heparin induced thrombocytopenia (HIT)
Hepatic
Hepatotoxicity
Heroin, morphine, oxycodone
Hexamethonium, trimethaphan
High therapeutic index
Hot flushes
Hydralazine
Hydrocortisone (cortisol), cortisone
Hydroxychloroquine
Hydroxyurea
Hyperkalemia, malignant hyperthermia
Hyperprolactinemia, galactorrhea
Hypersensitivity (rash), nephrotoxicity, myopathy, myelosuppression
Hypertension
Hypertensive crisis
Hypertrichosis
Hyperuricemia, hypokalemia, metabolic alkalosis and ototoxicity
Hyperuricemia, hypokalemia, metabolic alkalosis, hyperlipidemia, and
hyperglycemia
Hypoglycemia
Hypoglycemia
Hypokalemia
Iatrogenic Cushing's syndrome, hyperglycemia, impaired wound healing,
osteoporosis, peptic ulcers, myopathy, adrenal suppression (> 2 week
treatment)
IFN + nucleoside reverse transcriptase inhibitor (NRTI)
IFN + ribavirin + protease inhibitor (-previr)
IgE mediated allergic reaction (allergic rhinitis, urticaria)
Imatinib
Imipramine
Impair absorption of fat soluble vitamins (A,D,E,K)
Increase duration of GABAA chloride channel opening
Increase frequency of GABA-mediated chloride ion channel (GABAA) opening
Increases concentration of digoxin
Indomethacin
Indomethacin, naproxen
Induce CYP450
Inducers of CYP450
Infants
Infants, closed angle glaucoma, prostatic hypertrophy
Infliximab and etanercept
Inhalation anesthetics (isoflurane), antibiotics (aminoglycosides,
tetracyclines)
Inhibit 5-HT2 receptors
Inhibit CYP450 3A4
Inhibit dihydropteroate synthase
Inhibit DNA gyrase (topoisomerase II) and topoisomerase IV
Inhibit epithelial sodium channels in the distal convoluted tubules and
collecting duct
Inhibit mineralocorticoid (aldosterone) receptor resulting in inhibition of Na/K-
ATPase and ENaC synthesis
Inhibit Na+/Cl- cotransport
Inhibit Na+/K+ ATPase and indirectly increase intracellular calcium and
cardiac contractility
inhibit prostaglandin synthesis by inhibiting cyclo-oxygenase (cox)
Inhibit protein synthesis by binding to 23S rRNA of 50S ribosome subunit
Inhibiting platelet aggregation
Inhibitors of CYP450
Inhibits D2 receptors
inhibits HMG COA reductase
Inhibits microtubule assembly, decreases leukocyte migration and
phagocytosis
inhibits Na+/K+/2Cl- cotransporter
Inhibits osteoclast activity and prevent bone resorption
Inhibits phosphodiesterase-5, enhancing effects of nitric oxide-activated
increases in cGMP
Inhibits thyroid peroxidase
Insulin, EGF, TGFbeta, PDGF, ANP
Interferon alpha-2b
Iodide salts (potassium iodide)
Ipratropium, tiotropium
Irinotecan, topotecan
Irreversible inhibition of monoamine oxidase A and B
Irreversibly blocks COX1 and COX2
IV and SC
Ketamine
Ketoconazole
Ketoralac
Ketoralac
Kidneys
Labetalol and carvedilol
Lactic acidosis
Latanoprost
LD50
Leflunomide
Less extrapyramidal symptoms, more effect against negative symptoms of
schizophrenia
Leucovorin
Leuprolide
Leuprolide
Levodopa (L-dopa)
Levothyroxine (T4)
LFT's, creatine kinase
Liothyronine (T3)
Lipid solubility
Lipoprotein lipase
Lithium
Liver toxicity
Loading dose (Cp*(Vd/F))
Loop diuretics (furosemide, ethacrynic acid, butmetanide)
Lorazepam, oxazepam, and temazepam
Low pH
Low therapeutic index
Low-dose methotrexate
LSD (lysergic acid diethylamide)
Lupus-like syndrome
Lyse thrombi by catalyzing the formation of plasmin which cleaves fibrin
Magnesium sulfate
Maintenance dose (Cp*(CL/F))
Malathion, parathion
Malignant hyperthermia
Mallory-Weiss syndrome, hepatitis, cirrhosis, pancreatitis
Mannitol
Marijuana
Megaloblastic anemia
Memantine
Meperidine
Meperidine
Mesna
Metformin
Methadone, buprenorphine
Methadone, buprenorphine
Methamphetamine
Methamphetamine (crystal meth), MDMA (methylenedioxymeth-
amphetamine, or ecstasy)
Methicillin, nafcillin, and dicloxacillin
Methimazole and propylthiouracil (PTU)
Methotrexate
Methoxyflurane
Methyldopa
Metronidazole
Metronidazole
Metyrapone
Microsomal ethanol oxidizing system (MEOS)
Midazolam
Midodrine
Mifepristone (RU486)
Minimal alveolar concentration (MAC)
Minoxidil
Miosis, constipation
Mirtazapine
Monoamine oxidase inhibitors
Morphine
Morphine and fentanyl
Morphine, methadone, meperidine, and fentanyl
Mostly in the brain
Mupirocin
Myelosuppression
Myelosuppression (neutropenia)
N-acetylcysteine
Naloxone
Naloxone
Naloxone (IV)
Naltrexone
Naltrexone
Nateglinide
Neostigmine
Neostigmine
Nephro and ototoxicity
Nephrotoxicity
Nesiritide
Neuroleptic malignant syndrome
Neurologic deficits (Peripheral neuropathy)
Neuromuscular blocking drugs
Neutral protamine Hagedorn (NPH) insulin
Neutropenia and agranulocytosis
Nevirapine, efavirenz, etravirine
Niacin, fibrates
Nifedipine, amlodipine, nimodipine (dihydropyridines)
Nitrates, calcium channel blockers, beta blockers
Nitrites, thiosulfate, hydroxocobalamin
Nitrofurantoin, trimethoprim-sulfamethoxazole, fosfomycin
Nitroprusside
Nitroprusside, nitroglycerin
Nitrous oxide
Nitrous oxide
Nitrous oxide
Non-nucleos(t)ide reverse transcriptase inhibitors
Noncompetitive antagonist
Nondepolarizing blockers
Nonselective antimuscarinic
Nortriptyline, desipramine
NSAIDs
NSAIDS
Octreotide
Ondansetron and -setrons
Opioid
Opioid
Opioids
Oral
Oral vancomycin
Orange urine discoloration
Orthostatic hypotension (especially with first dose) and reflex tachycardia
Oseltamivir or Zanamivir
Osteoporosis, Paget's disease, hypercalcemia
Ototoxicity
Oxidation, reduction, hydrolysis
Oxybutynin
Oxytocin
Paclitaxel, -taxels
Pancuronium
Pancytopenia
Paresthesias, alkalization of the urine (precipitate Ca salts), hypokalemia,
metabolic acidosis, and encephalopathy in patients with hepatic impairment
Partial agonist
Patch, gum, lozenge, bupropion, varenicline
PCP (phencyclidine, or angel dust)
Pegloticase
Penicillamine
Phenoxybenzamine
Phentolamine
Phenylephrine
Phenytoin
Phosphodiesterase
Physostigmine
Physostigmine
Physostigmine, echothiophate
Pilocarpine
Pilocarpine or Cevimeline
Pilocarpine, carbachol
Pindolol and acebutolol
Pioglitazone, rosiglitazone
Piperacillin and ticarcillin
Porphyria
Positive Comb's hemolytic anemia, SLE-like syndrome, CNS depression
Potassium channel blockers
Potency
Potential for development of Reye's syndrome
Potentiation of GABA at GABAA receptors; also reduce Na and Ca influx
Pramipexole and ropinirole
Pramlintide
Prazosin, terazosin, doxazosin
Pre-existing cardiac or renal disease
Prednisone, prednisolone
Prednisone, prednisolone, methylprednisolone, and triamcinolone
Pregnancy
Pregnancy
Pregnancy, hyperkalemia
Prevent mast cell degranulation (by blocking opening of Cl- channels)
Primaquine
Probenecid
Prolonged vasospasm and hallucinations resembling psychosis
Prolongs QT interval
prolongs QT interval
Propofol
Propranolol
Propylthiouracil (PTU)
Prostaglandin E1 (misoprostol), PGE2, and PGF2alpha
Protamine Sulfate
Protease inhibitors
Pulmonary embolism, severe deep vein thrombosis
Pyridostigmine
Radioactive iodine
Raloxifene
Rebound hypertension, sedation, dry mouth
Reduce heart rate, blood pressure, contractility, and increase end-diastolic
volume
Reducing preload
Reflex tachycardia, hypotension, flushing, and throbbing headache due to
meningeal artery dilation
Regular insulin
Repaglinide
Requires enzymatic release of NO, relaxes vascular smooth muscle of veins
Respiratory and cardiovascular depression
Respiratory failure
Retinopathy
Rhabdomyolysis
Rhabdomyolysis and Hepatotoxicity
Rheumatic diseases
Ribavirin
Rifampin
Rifampin, Isoniazid, Pyrazinamide, and Ethambutol
Risperidone
Risperidone, ziprasidone
Rituximab
Salmeterol
Scopolamine
Scotch tape technique and mebendazole (albendazole)
Sedation, anticholinergic
Seizures
Selective serotonin reuptake inhibitors (SSRI)
Selectively inhibits monoamine oxidase B
Selegiline
Serotonin Syndrome
Sevoflurane
Short-acting barbiturates (pentobarbital)
Sinus tachycardia and serious arrhythmias
Sitagliptin, saxagliptin, linagliptin
Skeletal muscle tremor
Smooth muscle and mast cells; stomach, heart, and mast cells; nerve
endings, CNS respectively
Sodium bicarbonate (alkalinize plasma)
Sodium bicarbonate (alkalinize urine), dialysis
Sodium channel blockers
Somatropin
Sotalol
Specificity
Spironolactone, eplerenone
Steady state
Steroid and hormones
Stevens-Johnson syndrome
Stimulates cGMP, leads to vascular smooth muscle relaxation
Streptokinase
Streptomycin
Stunted bone growth and teeth discoloration for children under 8 years of
age
Succinylcholine
Sulfasalazine
Sulfonamides
Sulfonamides
Sumatriptan and -triptans
Suppress REM
Systemic lupus erythematosus, peripheral neuritis, hepatitis
Systemic lupus-like syndrome
Tamoxifen
Tamsulosin
TD50
Tenofovir, lamivudine
Terbutaline
Testosterone
Tetrabenazine, reserpine
Tetracycline
Therapeutic index
Thiazides
Thick ascending limb
Thiopental
Thioridazine
Thrombocytopenia
Thyroid dysfunction, corneal deposits, liver damage and pulmonary fibrosis
Ticlopidine
Timolol
Timolol (nonselective), betaxolol (selective), carteolol (nonselective)
Tinnitus, GI bleeding
Tolbutamide
Tolerance
Tolerance and physical dependence
Tolvaptan and conivaptan
Torsades de pointes
Trastuzumab
Trazodone
Tremor, hypothyroidism, nephrogenic diabetes insipidus, fetal cardiac defects
Tubocurarine
Typical antipsychotics
Uterine contractions
Valproic acid
Valproic acid
Valproic acid, carbamazepine, gabapentin
Vancomycin
Vasodilation
Vemurafenib
Verapamil, diltiazem (non-dihydropyridines)
Vinblastine
Vincristine
Vitamin B12
Vitamin D
Vitamin K1 and fresh frozen plasma
Volume of distribution (VD)
Warfarin (PT)
Weight gain, edema, heart failure, hepatotoxicity
Wernicke-Korsakoff syndrome
You have 1 heart (Beta 1) and 2 lungs (Beta 2)
Zafirlukast and montelukast
Zero order kinetics
Zidovudine, nevirapine
Zileuton
Zolpidem, zaleplon, eszopiclone