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The University of Faisalabad

Contact Total Periods


Credit Hours
PHARMACEUTICS-VII (Hospital Hrs/Week Allocated
Course Code
PH-601 Pharmacy-I) Th 3
3 48

MAIN AIMS OF THE COURSE


The student will have an awareness of:

The purpose and workings of a collective agreement by reviewing the Provincial


Health Sciences Agreement.

The impact of collective agreements on managerial decisions.

The scope and functions of pharmacy operations in a hospital pharmacy including:

o Drug distribution systems (ex. automatic substitution and stop dates)

o Drug information

o Seamless care

o Formulary systems & DTC

o IV administration

o Inpatient & Outpatient services

o Training and certification programs

o Wardstock

The methods by which hospital pharmacy budgets are set and controlled.

The structure of regional pharmacy services.

The "tender" process for the bulk purchasing of pharmaceuticals .

Course for:

Doctor of pharmacy

Course for:

 Pharm-D
Books:
Sr. No. Title Author (s)

1 Hospital pharmacy Nadeem Irfan Bukhari


2 Hospital pharmacy William E. Hassan
3 Hospital pharmacy Martin Stephens

Week Description chapter

1- INTRODUCTION 1
(a) Role of Pharmacist in Hospital.
(b) Minimum standards for pharmacies in Institutions/Hospitals.
(c) Research in Hospital Pharmacy.

2 HOSPITAL AND ITS ORGANIZATION 2


(a) Classification of Hospitals.
(b) Organizational Pattern.
(c) Administration.
3 (d) Clinical Departments.
(e) Nursing, Dietectic, Pathology, Blood Bank, Radiology and other supportive
services etc.
(f) Role of Pharmacy in Hospital.
(g) Hospital Finances.Semi-sterile (Ear drop, Eye drop)
4 PHARMACY, ITS ORGANIZATION AND PERSONNEL 3
(a) Pharmacy specialist.
(b) Drug information Centre.
(c) Poison Control Centre and Antidote Bank.

5 (d) Pharmacy Education.


(e) Determining the need of Professional and other departmental staff.
(f) Professional services rendered.

6 PHARMACY AND THERAPEUTIC COMMITTEE. 4

(a)Composition and membership

(b)Purpose of committee

(c)Organization and operation

7 (d)Functions and scope

(e)Effective pharmacy and therapeutics committee

(f)policies of the committee

(g)Role of PTC in hospital

8 THE HOSPITAL FORMULARY 5


(a) General Principles and guidelines to develop Formulary.
(b) Format.
(c) Preparation of the Formulary & Role of Pharmacist.
(d) Benefits and problems.
(e) Keeping up-to-date Formulary.
(f) Contraceptives.

9 MID EXAM

10 DISPENSING TO AMBULATORY PATIENTS 6


(a) Categories of ambulatory patient care.
(b) Dispensing to outpatients
(c)Safe and effective use of drugs.
11 DISPENSING TO INPATIENTS 7
(a) Methods of Dispensing & SOPs.
(b) Unit dose dispensing. (c) Other concepts of dispensing, Satellite Pharmacy
etc.
12 DISPENSING DURING OFF-HOURS. 8

(a) Introduction,Means for off-hour dispensing

(b)Emergency medication supply

13 (c)Night drug cabinets

(d)Dispensing by physicians

(e)Purchased service/part time pharmacist service

14 DISTRIBUTION OF CONTROL SUBSTANCES 9

(a)Introduction, hospital control procedures

(b) Charges to patients for narcotics.

(c) use of controlled drugs in Researc

Assignments & presentations

15 SAFE USE OF MEDICATION IN THE HOSPITAL 10


(a) Medication error.
(b) Evaluation & Precautions of Medication Error.
16&17 (c) Role of Pharmacist in Controlling Medication Error.

18 FINAL EXAM

Assessment Scheme:
Quizzes+ Test 04%
Assignments 04%
Attendance 02%
Minimum attendance required: 85 percent
Mid-term Examination (written) 15%
Final Examination (written) 25%
Contact Total Periods
Course Code PHARMACEUTICS-VIII Credit Hours
Hrs/Week Allocated
PC 603+605 (clinical pharmacy-I)Th+Lab 3+1
3+1 48+16

MAIN AIMS OF THE COURSE


The course has the following main aims:
 aimed at different aspects of drugs and pharmaceuticals used in different diseases
 Process of drug interaction with cellular macromolecules to alter physiological function and site
of action including knowledge about proper selection of drugs is also covered.
 To give the strong knowledge of drugs along with their
indications,brands,contraindicatona,doses,adverse effects,interactions

Course for:

 Pharm-D
Books:

Sr. No. Title Author (s)

1 Clinical Pharmacy & Therapeutics Roger Walker

2 Drug Disease Management Herfindal Gourley

3 Pharmaceutical Practice A J Winfeild

Weeks GENERAL INTRODUCTION TO CLINICAL PHARMACY


WEEK 1: Back ground of clinical pharmacy
History
Clinical pharmacy processes
Development of clinical practice in pharmacy
Medication related problems&catagories
Pharmaceutical consultation&processes&phases
Key elements of care
Prescribing
Clinical pharmacy functions&knowledge

WEEK 2: TERMINOLOGIES
All def&concepts
Scope of pharmacy
Aim&goal
WEEK:3 BASIC COMPONENTS.
Introduction
Communicatio
Consulting
Detailed introduction of..
PWDT
SOAP
CORE
PRIME
Documentation of pharmaceutical care

WEEK:4 PATIENT PROFILE


Findings
Management
WEEK:5 PATIENT DISEASE PROFILE
Introduction
Interpretation of laboratory data
WEEK:6 TAKING CASE HISTORY
WEEK:7 DRUG PROFILE
Adrenaline
Aminoglycosides
WEEK:8 . Anti-TB
. Cimitidine
WEEK:9 MID EXAM
WEEk:10 Antileptics
Atropine
Benzodiazipine
WEEK:11 Cephalosporin
Chlorphenerane
Vancomycin
WEEK:12 Dobutamine
Dopamine
Salbutamol
WEEK:13 Fluroquinolones
Frusimide
Lactulose
Prednisolone
WEEK:14 Macrolides
Metoclopramide
Morphine/pethedine
WEEK:15 Nefedipine
NSAIDS
ORS
Penicillines
WEEK:16 Clinical trials of drug substances
Designing of clinical trials
Choice of patients
Types of trials
Exclusion of patients&monitoring clinical trials

WEEK:17 Emergency treatments


Drugs used in emergency treatment
Presrentations&assignments
WEEK:18 FINAL EXAM
603PHARMACEUTICS-Viii (Laboratory) Cr. Hr. 01

Clerkship in the Clinical setting. A project related to Clinical Pharmacy

Practices will be completed by the students and will be evaluated by the

external examiner.
Pharmaceutics-IX(Industrial Contact Total Periods
Course Code Credit Hours
Pharmacy I) TH+Lab Hrs/Week Allocated
607+609 3+1
3+1 48+16

INSTRUCTOR AND CONTACT INFORMATION


Course Instructor: Mrs. Uzma Ali
Email: uzmayali@yahoo.com
MAIN AIMS OF THE COURSE
The course has the following main aims:
 To understand the construction and working of the equipments used in pharmaceutical industry.
 To identify different problems countered during the manufacturing of different dosage forms.
 To study about different dosage forms and their significance according to manufacturing point of
view.
Books Recommended:

Sr. No. Title Author (s)

1 Theory and Practice of industrial Pharmacy Lachmann


2 Tutorial Pharmacy Cooper and gunns
3 Remingtons Pharmaceutical sciences Volters Kluwer and Lippincott Willian
4 Good Manufacturing Practice John Sharp

5 Bentleys text book of Pharmaceutics A.C Bentley

6 The Design and Manufacture of Medicines Micheal E. Aulton

Weeks Topics
1. Mass Transfer
Solid/ Fluid Mass transfer,
Fluid/Fluid Mass Transfer, Influence on Unit Operation
2. Heat Transfer, Design of heating equipments,
Radiant heat transmission, Combination of heat transfer methods
Practical aspects of the use of steam
3. Drying
Theories of drying, Drying of solids,
Classification of dryers,
General methods, Fluidized bed systems
4. Pneumatic systems
Spray Dryers
Freeze Dryers
5. Mixing
Fundamentals, Mechanisms, Equipments
Liquid/ Liquid
Liquid/Solid
Solid/Solid mixing
6. Communition
Reasons for size reduction
Factors affecting size reduction
Size analysis
Energy Mills
7. Safety Methods in Pharmaceutical Industry
a) Mechanical
b) Chemical
c) fire hazard problems
Quiz
Grand Test
8. Inflammable gases and dusts
9. MID EXAM
10. Clarification and Filtration
Theory, Filter media,
Filter aids, Filter selection
11. Equipments used in filtration process
Leaf Filters, Filter press,
Meta Filters, Rotary Filters
12. Evaporation
General Principles of evaporation
Evaporators and evaporation under reduced pressure
13. Compaction and Compression
The solid-air interface
Angle of repose
14. Flow Rates, Mass-Volume relationship
Density
Heckal Plots, Consolidation, Friability
15. Granulation Technology
Granulation Technology
Test
16. Physics of tabletting,
Tabletting machine,
Problems involved in tabletting
17. Compression (Dry methods)
( Wet Methods, Slugging)
Presentation
Lecture 1. Grand Test
Lecture 2. Presentation
Lecture 3. Final Briefing
18. FINAL EXAM

Recommended Practical Topics

No. Practical Name


1 Preparation of lactose Granules
2 Preparation of 250g of Methyl Cellulose Granules
3 Calculate %age MC and %age LOD in granules by Drying
4 Determination of Angle of Repose and compare the flow properties of Powders
5 Manufacturing of 48 Ampicillin Capsules
6 Communition of the material by Ball Mill
7 Preparation of 1L Antidiabetic Syrup by Silverson Mixer
8 Determination of Bulk Density and Porosity of Granules
9 Determination of Flow rates of given Granules
10 Preparation of FeSo4 Tablets by wet granulation method
11 To approve or reject the IN-Process batch of tablets during in Q . C

Assessment Scheme:
Quizzes+ Test 04%
Assignments 04%
Attendance 02%
Minimum attendance required: 85 percent
Mid-term Examination (written) 15%
Final Examination (written) 25%
Practical 50%
University of Faisalabad
Contact Total Periods
Course Code Pharmaceutics-X (Bio-pharmaceutics-I) Credit Hours
Hrs/Week Allocated
611&613 Th+Lab 3+1
3+1 48+16

INSTRUCTOR AND CONTACT INFORMATION

Course Instructor: Ms Rahila Fazal

Email:rahila.fazal@gmail.com

BRIEF COURSE DESCRIPTION

This course is designed to enhance the students understanding of biopharmaceutics Including Basic
principles & the applications of pharmacokinetic principles in different fields.

COURSE OBJECTIVES

This course has following main objectives

To understand basics of pharmacokinetics principles and enable the students to apply these principles in
different clinical areas and designing and monitoring dosage forms and dosage regimens.

Prerequisite(s): None

Recommended Text Books:

Sr. No. Title Author (s)

Applied Biopharmaceutics and Leon Shargel


1
Pharmacokinetics, 5th edition

Leon lachmann,
The Theory and practice of pharmacy, 3rd
2 H. A. Leiberman,
edition
J. L. Kanig

3 Aultons Pharmaceutics M. E. Aulton

4 Biopharmaceutics and Pharmacokinetics J.S. Kulkarni

5 Basic pharmacokinetics M. A. Hedaya


CONTENTS:
WEEKS CHAPTER TITLE/TOPICS TOPICS COVERED
1.Biopharmaceutics
Generic equivalence
Bioavailability
Bioequivalance
DEFINITIONS AND 2.Drug disposition
TERMINOLOGY Therapeutics
1
Pharmacokinetics
Pharmacodynamics
3.Toxicokinetics
Biotransformation
Therapeutic equivalents
Therapeutic window
PHYSIOLOGIC FACTORS 1.Passage of drug across cell membrane
RELATED TO DRUG Passive diffusion
ABSORPTION Carrier mediated transport
2. Active transport
2 Facilitated diffusion
Vesicular transport
Pore transport
Ion pair formation
3. PH Partition theory
1. Drug absorption in gastrointestinal tract
2. Gastrointestinal motility
3. Gastric emptying time
3-4 1. Intestinal motility
2. Effect of food on GI drug absorption
3. Double peak phenomenon

1.Factors effecting bioavailability


5 2.Physiochemical considerations
3.significance of bioavailability
BIOAVAILABILITY STUDIES 1.Bioavailability
2.Relative bioavailability
6
3.Absolute bioavailability

1.Methods of assessing bioavailability


Plasma drug conc
Urinary drug excretion
2.Acute pharmacodynamic effect
3.Clinical observation
In vitro studies

DRUG DISSOLUTION 1.Factors effecting drug dissolution


2.Methods for in-vivo and in-vitro determination of rate of
8
dissolution
3.In-vitro-In-vivo correlation
9 MID EXAM
10 1.One compartment model drugs
INTRAVENOUS INFUSIONS 2. Steady state drug concentration
Time to achieve Css
3. Infusion method for calculating patient half life

1.Loading dose plus IV infusion


11 2.Drug clearance and Vd
3.Numericals
MULTIPLE DOSAGE 1.Intoduction
REGIMEN Adjusting parameters
12
2.Drug accumulation
3.Superposition principle
1.Superposition principle
2.Derivation
13
3.Significance

BIOPHARMACEUTICAL AND Physiochemical properties for consideration in drug product design


PHARMACOKINETIC Particle size
ASPECTS IN DEVELOPING Polymorphism
14
DOSAGE FORM Partition coefficient
PH
Stability
Dissolution conditions
15
PRESENTATIONS
Drug product considerations
1.Pharmacokinetics of drug
16

2.Bioavailability of drug
17
3.Dose considerations
18 FINAL EXAM
Please note: This is a proposed schedule only and may be varied at the discretion of the instructor to give
a greater or lesser degree of emphasis to particular topics.
Recommended Practical Topics

No. Practical Name


1 To understand handling of animals
2 To administer a drug to animals by oral route
3 To administer a liquid drug to animals by parentral route
4 To withdraw blood samples from animals
5&6 To construct a calibration curve from a graph between absorbance and known conc of drug for
determination of unknown conc graphically.
7&8 To determine unknown concentration of drug at different time intervals and to determine order of
kinetics.
9 Mid Exam
10 To determine and compare the order of kinetics for the given data sets.
11 To determine the dissolution profile using USP dissolution apparatus for a tablet containing 500mg of
drug.
12&13 To compare dissolution profile of a test tablet formulation to that of commercially available reference
formulation
14 To plot data on rectilinear and semilog graph paper and determine parameters.
15&16 To calculate pharmacokinetic parameters of drug assuming one compartment model after IV
administration.
17 To determine absolute bioavailability of drug.
18 Final Exam
Assessment Scheme

 Quizzes 10%
 Assignments 05%
 Attendance 05%
 Mid Term Exam 30%
 Final Exam 50%
The University of Faisalabad
PHARMACEUTICS-XI Contact Total Periods
Course Code Credit Hours
(Pharmaceutical Quality Hrs/Week Allocated
615&617 3+1
Management-I) Th+Lab 3+1 48+16

INSTRUCTOR :

Course Instructor: Rozina Kousar

BRIEF COURSE DESCRIPTION

This course is designed to enhance the students understanding of Quality Management (Quality Control
& Assurance) in Pharmaceutical Areas.

COURSE OBJECTIVES

This course has following main objectives

To understand basics concepts of Quality Management.

Prerequisite(s): None

CONTENTS:

Weeks TOPIC/CHAPTER TITLE TOPICS COVERED


1 1. An understanding of the testing,

2. Quality control programme and


SCOPE
methods adopted in a pharmaceutical industry. Dosage
form control,

3. General understanding of Total Quality Assurance


and measures to Adopt

2 Physical tests:

QUALITY CONTROL OF 1. Hardness,


2. Thickness and Diameter,
SOLID DOSAGE
3. Friability
FORMS(Tablets) CLASS TEST

3 1. Disintegration,
2. Weight Variation.
3. Other tests
4 Chemical tests:
1. Content uniformity,
2. Assay of active ingredients and
3. Dissolution tests of Powders, Granules,
Tablets
5 CLASS TESTS

6 QUALITY CONTROL OF 1. Disintegration test


SOLID DOSAGE 2. Uniformity of weight
FORMS(Capsules) 3. Assay of active ingredients & other tests

7&8 QUALITY CONTROL OF 1. Viscosity


SYRUPS AND ELIXIRS 2. Its determiantion and application in the Quality
Control of Pharmaceuticals
3. Weight per ml and Assay of active ingredients

9 MID EXAM

10 EVALUATION OF 1. Stability of viability rate during storage


SUSTAINED ACTION 2. In-vitro & In-vivo evaluation
PRODUCTS (TABLETS & of sustaining action.
CAPSULES):
3. Other tests for suppositories
11 QUALITY CONTROL OF 1. Leakers test,
STERILE PRODUCTS 2. Clarity test,
(PARENTERALS) 3. Pyrogen test for parenterals and other sterile
preparations Assay for active ingredients
12 QUALITY CONTROL OF 1. Disintegration test,
SUPPOSITORIES 2. Uniformity of weight,
3. Assay of active ingredients,
13 1. Liquefaction time test
2. Breaking test.
3. Melting Range Test
14 STATISTICAL QUALITY 1. Study of statistical Quality Control Charts
CONTROL CHARTS 2. Study of statistical Quality Control Charts
3. Study of statistical Quality Control Charts
15 CLASS TESTS PRESENTATIONS

16&17 SOPs & GMPs 1. Understanding of SOPs


2. Understanding of GMPs
3. Class Grand Test
18 FINAL EXAM

Please note: This is a proposed schedule only and may be varied at the discretion of the instructor to give
a greater or lesser degree of emphasis to particular topics.
Recommended Practical Topics

1- Practicals of the subject shall be designed from time to time on the


basis of the above mentioned theoretical topics and availability of the

facilities, e.g.

2- Quality Control tests for Tablets.


3- Quality Control tests for Capsules.
4- Quality Control tests for syrups.
5- Assay of various spirits, tinctures, extracts, syrups and
elixirs,

6- Assay of Ointments and suppositories,


7- Assay of tablets and capsules,
8- Test for alkalinity of glass.
Recommended Books

1.Sydney H Willig, Good Manufacturing Practices for Pharmaceuticals,

Marcel Dekker Publishing.

2.Karamt A Javaid, Pharmaceutical Quality Assurance in Class,

Industry and Market, Aziz Publishers, Lahore-Pakistan (1993).

3.Lackman, Theory and Practice of Industrial Pharmacy, Verghese

Publishing House, Bombay, 1987.

4. Remingtons Pharmaceutical Sciences, Mack Publishing Company,

USA, 2001.

5.Pharmacopoeias B.P, U.S.P, U.S.P/N.F, P.P.

Assessment Scheme

 Quizzes 10%
 Assignments 05%
 Attendance 05%
 Mid Term Exam 30%
 Final Exam 50%