THE INFLAMMATORY PROCESS

Trauma or injury
Cell membrane Phospholipids

Tissue damage Activates Phospholipase A2 Steroids

Release of Arachidonic Acid

Production of damage associated molecular
COX-1 and COX-2
patterns DAMPS (ECM matrix breakdown
inhibitors, aspirin,
products and intracellular alarmins) indomethacin

Signal through PRRs on synoviocytes A and B Cyclooxygenases Lipoxygenase

Prostaglandins (PGI2, PGE1, Leukotrienes (C4, D4, E4,

Local production of inflammatory mediators Thromboxanes, etc.) etc.)