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was 32 years and the latency of lung cancer was 50 quantied, while with the Condence intervals (CI),
years. For Goddard score of emphysematous changes, the statistical signicance for the error level less 0,05
28% showed 0 point and 33% of 1w4 points and more (p) was deend.
than 21 points occupied only 4%, which means very low Results: According to the investigation results, malig-
percentages of emphysematous changes for these nant disease of two members in one family was found
asbestos-related lung cancer, nonetheless of high per- in 13,5% of the IG, 9,4% of the CG, respectively. Cur-
centages of heavy smokers. For pulmonary function test, rent smokers (CS) with present hereditary factor had
FEV1.0% is 70.5%11.3% and % FEV1.0 is 85.622.2%. almost 4 times (OR3,95; 95% CI, 1,78-8,77), greater
More than half patients are normal pulmonary function risk to become ill compared to the never smokers (NS)
except more than 1,000 of Brinkman index or more than without hereditary factor. The risk was greater when
15 points of Goddard score. From the classication of the same would be compared to the NS with present
GOLD criteria, 54.1% are normal, stage 1 is 20.7%, stage hereditary factor (OR8,76; 95%CI, 1,80-42,68). In the
2 is 22.5 % stage 3 is 1.8% and stage 4 is only 0.9%. diseased, the professional exposition was present in
Conclusion: Almost all of asbestos-related lung cancer 68,6% from IG, versus 67% in the CG. The highest risk
in Japan are heavy smoker, but 61% showed none or low for LC was found in transport workers (OR2,50;95%
grade of emphysematous changes by chest CT and only CI, 1,01-6,15) and automehanics (OR2,31;95%CI,
2.7% had severe pulmonary dysfunction. 0,76-7,07). CS represented 67% of diseased in-
Keywords: Asbestos, smoking, emphysema lung cancer dividuals versus 40,5% of the CG. The risk for them to
develop LC was 5,54 (95%CI, 3,0-10,23), times
signicantly greater compared to the NS. The risk for
the disease was signicantly greater in individuals
P1.01-014
who were smoking >20years (y), >20cigarettes/day
The Role of Hereditary Factor, (c/day), compared to those, who, in the same time
Profession and the Habit of Cigarette period, smoked <20c/day (OR3,78; 95% CI, 2,04-
Smoking in Developing Lung Cancer 7,01). The risk to develop LC in former smokers (FS),
who >20y smoked >20c/day was 2,40 (95% CI,
Topic: Tobacco, Radon, Air Pollution, Other Risk
0,94-6,14), times greater compared to those, who
Factors
smoked >20y, <20c/day.
Irina Pavlovska,1 Nikola Orovcanec,2 Conclusion: This disease developed twice more
Biljana Tausanova,2 Beti Zarova2 1Department of commonly in the examined individuals, exposed to pro-
Epidemiology, Institute of Epidemiology and Biostatistics, fessional carcinogens. The LC is multifactor disease for
Skopje/Macedonia, 2Department of Epidemiology, which development, besides smoking, as a main deter-
Institute of Epidemiology and Biostatistics, Medical minant, in mutual interaction are the genetic and other
Faculty, Skopje/Macedonia factors of the surrounding and the way of living.
Keywords: lung cancer, hereditary factor, cigarette
Background: Lung cancer (LC) is the most common and smoking, occupation
deadliest cancer in the world. In the Republic of
Macedonia, within the period 2002-2012, the LC took the
rst place according to the frequency of appearing in
men, while it was on the fourth place in women. The P1.01-015
number of the risk factors is great being connected with Polyphenols-Rich Fruit Extracts Prevent
the occurrence of LC. The aim of this study was to
Tobacco Specic Nitrosamine-Induced
analyze the role of genetic factor, professional exposure
and the habit of cigarette smoking in occurrence of lung DNA Damage in Lung Epithelial Cells
cancer. Topic: Protective Factors, Risk Reduction,
Methods: The research was conducted as a case-con- Smoking Cessation
trol study. It included 185 patients diseased of LC
(investigated group-IG) and the same number of per- D.I.M. Amararathna,1 D.W. Hoskin,2 M. Johnston,3
sons without malignant disease (control group-CG). In H.P.V. Rupasinghe1 1Environmental Sciences, Dalhousie
the study were included only interviewees with University, Truro/NS/Canada, 2Pathology, Microbiology
pathohistologically conrmed LC. Through calculating and Immunology, and Surgery, Dalhousie University,
the risks of the Odds ratio (OR), the risk-factors, Halifax/NS/Canada, 3Beatrice Hunter Cancer Research
which had a role in occurrence of the disease, were Institute, Halifax/NS/Canada