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NOREPINEPHRINE

Norepinephrine is similar to adrenaline. It works by constricting the blood vessels and


increasing blood pressure and blood glucose levels.[1]

In addition, Norepinephrine is made in specific neurons, which is complex systems. They


are highly located at nerve terminals, largely within synaptic vesicles. In generally, the
metabolism of norepinephrine in the brain is similar to that in the peripheral sympathetic
system.[5]

Used of C8H11NO3
Norepinephrine is used to
treat life-threatening low blood
pressure (hypotension) that can
occur with certain medical
conditions or surgical
procedures. This medication is
often used during CPR (cardio-
pulmonary resuscitation).[1]

Chemical Property
Propertys Name Propertys Value

Formular C8H11NO3 [2]

Molecular Weight 169.18 g/mol [2]


Physical Property Formal Charge 0 [3]

Propertys Name Propertys Value IUPAC Name 4-[(1R)-2-


amino-1-
Physical State Solid [2]
hydroxyethyl]benz
Color Colorless micro-crystals [2] ene-1,2-diol [2]

Melting Point 217 dec C [2] Dissociation 8.58 [2]


Constant (pKa)
Solubility Slightly soluble in water, ethanol, diethyl
ether; very soluble in alkali, dilute pKa (Strongest 9.5 [3]
hydrochloric acid [2] Acidic)

Water Solubility 12.5 mg/mL [3] Decomposition emit toxic fumes


of NOx [2]
Vapor Pressure 7.5X10-8 mm Hg at 25 deg C (est) [4]
Sensitive Air & Light
Form Crystalline [4] Sensitive [4]

Reference
1. Norepinephrine, Retrieved at May17, 2017, from https://www.drugs.com/mtm/norepinephrine.html
2. Norepinephrine, Retrieved at May 17, 2017, from https://pubchem.ncbi.nlm.nih.gov/compound/norepinephrine#section=Top
3. Norepinephrine identification, Retrieved at May17, 2017, from https://www.drugbank.ca/drugs/DB00368
4. Norepinephrine identification, Retrieved at May17, 2017, from http://www.chemicalbook.com/ChemicalProductProperty_EN_CB8346810.html
5. Jacques G. & Ross B.(1959), METABOLISM OF NOREPINEPHRINE IN THE CENTRAL NERVOUS SYSTEM. Pharmacological Reviews, Vol. 18, Issue 4, pp.1227