Tabla 1: CIM de comp.

de Edwar Cortés ( panel de hongos convencionales)

Código Ca Ct Cn Afl Afu Ani Mg Tr Tm

NAT1 >250 >250 >250 >250 >250 >250 >250 >250 >250
NAT2 >250 >250 >250 >250 >250 >250 >250 >250 >250
NAT3 >250 >250 >250 >250 >250 >250 >250 >250 >250
NAT4 >250 >250 >250 >250 >250 >250 >250 >250 >250
NAT21 >250 >250 >250 >250 >250 >250 >250 >250 >250
NAT22 >250 >250 >250 >250 >250 >250 >250 >250 >250
NAT31 >250 >250 250/>250 >250 >250 >250 250/250 125/250 125/250

NAT32 >250 >250 125/250 >250 >250 >250 125/>250 125/>250 125/>250
NAT41 >250 >250 >250 >250 >250 >250 >250 >250 >250
NAT42 >250 >250 >250 >250 >250 >250 >250 >250 >250
GP 029 >250 >250 >250 >250 >250 >250 >250 >250 >250
GP 045 >250 >250 >250 >250 >250 >250 >250 >250 >250
GP 048 >250 >250 >250 >250 >250 >250 >250 >250 >250
GP 054 >250 >250 >250 >250 >250 >250 >250 >250 >250
GP 055 >250 >250 >250 >250 >250 >250 >250 >250 >250
GP 056 >250 >250 >250 >250 >250 >250 >250 >250 >250
GP 058 >250 >250 >250 >250 >250 >250 >250 >250 >250

2AP 4EA-POL >250 >250 >250 >250 >250 >250 >250 >250 >250

3AP 4EA >250 >250 62.5/>250 >250 >250 >250 >250 >250 >250
ASMA 25 >250 >250 >250 >250 >250 >250 >250 >250 >250
MJAM 02 250/>250 250/>250 31.25/250 >250 >250 >250 31.25/31.25 31.25/31.25 31.25/31.25
NIC 041 >250 >250 >250 >250 >250 >250 >250 >250 >250
NIC 067 >250 >250 >250 >250 >250 >250 >250 >250 >250
NIC 088 >250 >250 >250 >250 >250 >250 >250 >250 >250
NIC 089 >250 >250 >250 >250 >250 >250 >250 >250 >250
NIC 090 >250 >250 >250 >250 >250 >250 >250 >250 >250
NIC 091 >250 >250 >250 >250 >250 >250 >250 >250 >250
NIC 092 >250 >250 >250 >250 >250 >250 >250 >250 >250
NIC 093 >250 >250 >250 >250 >250 >250 >250 >250 >250

MIM 1 >250 >250 >250 >250 >250 >250 >250 >250 >250

MIM 2 >250 >250 >250 >250 >250 >250 >250 >250 >250

MIM 3 >250 >250 >250 >250 >250 >250 >250 >250 >250

MIM 4 >250 >250 >250 >250 >250 >250 >250 250/>250 250/>250

CR 6 >250 >250 >250 >250 >250 >250 >250 >250 >250

CR 7 >250 >250 >250 >250 >250 >250 >250 >250 >250

CR 8 >250 >250 >250 >250 >250 >250 >250 >250 >250

CR 10 >250 >250 >250 >250 >250 >250 >250 >250 >250

CR 15 >250 >250 >250 >250 >250 >250 >250 >250 >250
CR 22 >250 >250 >250 >250 >250 >250 >250 >250 >250

JLO 1 >250 >250 >250 >250 >250 >250 >250 >250 >250

JLO 2 >250 >250 >250 >250 >250 >250 >250 >250 >250

JLO 3 >250 >250 250/250 >250 >250 >250 >250 250/>250 250/>250

JLO 4 >250 >250 >250 >250 >250 >250 >250 >250 >250

JLO 5 >250 >250 >250 >250 >250 >250 250/>250 250/>250 250/>250

JLO 6 >250 >250 >250 >250 >250 >250 >250 >250 >250

JLO 7 >250 >250 >250 >250 >250 >250 >250 >250 >250

JLO 8 >250 >250 >250 >250 >250 >250 >250 >250 >250

JLO 9 >250 >250 >250 >250 >250 >250 250/>250 250/>250 250/>250

JLO 10 >250 >250 >250 >250 >250 >250 125/>250 125/>250 125/>250

EAS 1 >250 >250 >250 >250 >250 >250 >250 >250 >250

EAS 2 >250 >250 >250 >250 >250 >250 >250 >250 >250

EAS 3 >250 >250 >250 >250 >250 >250 >250 >250 >250

EAS 4 >250 >250 >250 >250 >250 >250 >250 >250 >250

EAS 5 250/>250 250/>250 250>250 >250 >250 >250 >250 250/>250 250/250

EAS 6 >250 >250 250>250 >250 >250 >250 >250 250/>250 250/250

NHP2 SOL 62.5/>250 125/250 250/>250 >250 >250 >250 250/250 125/125 125/125

ZNP2 SOL >250 >250 >250 >250 >250 >250 >250 >250 >250

3NP2 SOL >250 >250 >250 >250 >250 >250 >250 >250 >250

HNP2 SOL >250 >250 >250 >250 >250 >250 >250 >250 >250

BrP2 SOL >250 >250 >250 >250 >250 >250 >250 >250 >250

3NPIPE >250 >250 >250 >250 >250 >250 >250 >250 >250

PhP2 SOL >250 >250 >250 >250 >250 >250 >250 >250 >250

Me OA test >250 >250 >250 >250 >250 >250 >250 >250 >250

MeA test >250 >250 >250 >250 >250 >250 >250 >250 >250

TABLA 2: % de INH en C. neoformans
NAT1 NAT2 NAT3 NAT4 NAT21

250 μg/ml 76.80 ± 0.19 74.05 ± 1.28 75.13 ± 1.11 89.02 ± 0.35 27.24 ± 1.73
125 μg/ml 50.79 ± 0.66 63.37 ± 1.27 55.41 ± 0.19 66.14 ± 1.89 0.00
62,5 μg/ml 29.01 ± 1.21 26.56 ± 0.89 37.67 ± 0.21 38.93 ± 0.15 0.00
31,25 μg/ml 20.13 ± 1.65 25.75 ± 1.25 33.52 ± 0.30 20.10 ± 1.29 0.00
15.62 μg/ml 0.00 22.08 ± 0.78 32.99 ± 0.10 15.09 ± 0.85 0.00
7.8 μg/ml 0.00 18.62 ± 0.41 29.89 ± 0.18 14.08 ± 0.01 0.00
3.4 μg/ml 0.00 15.75 ± 0.33 26.59 ± 2.14 12.73 ± 0.89 0.00
control + 0.00 0.00 0.00 0.00 0.00

NAT22 NAT31 NAT32 NAT41 NAT42

250 μg/ml 16.73 ± 1.61 100.00 100.00 55.18 ± 1.12 69.11 ± 0.17
125 μg/ml 16.09 ± 1.53 84.72 ± 0.57 100.00 28.28 ± 0.45 48.69 ± 1.27
62,5 μg/ml 0.00 39.19 ± 0.38 82.27 ± 1.45 12.17 ± 1.34 47.21 ± 0.01
31,25 μg/ml 0.00 0.00 54.03 ± 1.21 11.32 ± 0.11 24.28 ± 1.67
15.62 μg/ml 0.00 0.00 16.35 ± 0.75 10.38 ± 0.16 17.71 ± 0.25
7.8 μg/ml 0.00 0.00 8.59 ± 0.12 8.42 ± 0.82 17.54 ± 1.33
3.4 μg/ml 0.00 0.00 2.15 ± 0.12 0.00 0.00
control + 0.00 0.00 0.00 0.00 0.00

GP 29 GP 045 GP 048 GP 54 GP 55

250 μg/ml 52.55 ± 0.63 47.34 ± 1.42 28.84 ± 0.06 47.57 ± 2.81 32.85 ± 0.13
125 μg/ml 43.61 ± 0.47 6.87 ± 0.64 17.26 ± 0.18 44.17 ± 1.34 18.46 ± 1.08
62,5 μg/ml 5.10 ± 0.64 5.31 ± 0.49 13.92 ± 0.02 18.52 ± 1.03 9.21 ± 0.04
31,25 μg/ml 0.00 0.00 8.54 0.20 0.00 5.93 ± 0.77
15.62 μg/ml 0.00 0.00 0.00 0.00 0.00
7.8 μg/ml 0.00 0.00 0.00 0.00 0.00
3.4 μg/ml 0.00 0.00 0.00 0.00 0.00
control + 0.00 0.00 0.00 0.00 0.00

GP 56 GP 058 2AP 3AP ASMA

250 μg/ml 46.67 ± 1.26 47.72 ± 0.58 67.84 ± 0.48 100.00 47.83 ± 0.28
125 μg/ml 18.97 ± 0.60 25.59 ± 0.78 47.37 ± 0.35 100.00 34.06 ± 0.44
62,5 μg/ml 13.61 ± 0.93 16.55 ± 0.14 43.63 ± 1.36 100.00 3.24 ± 0.39
31,25 μg/ml 10.27 ± 0.79 0.00 37.56 ± 1.12 57.00 ± 1.23 0.00
15.62 μg/ml 9.89 ± 0.10 0.00 34.86 ± 1.49 0.00 0.00
7.8 μg/ml 0.00 0.00 33.55 ± 1.78 0.00 0.00
3.4 μg/ml 0.00 0.00 20.00 ± 0.91 0.00 0.00
control + 0.00 0.00 0.00 0.00 0.00

MJAM NIC 041 NIC 067 NIC 088 NIC 089

250 μg/ml 100.00 14.24 ± 2.92 39.66 ± 0.10 12.42 ± 0.18 34.41 ± 0.01
125 μg/ml 100.00 10.79 ± 0.04 32.35 ± 1.70 11.61 ± 1.10 14.63 ± 0.53
62,5 μg/ml 100.00 9.28 ± 1.31 0.00 10.38 ± 0.59 0.00
31,25 μg/ml 100.00 9.27 ± 1.55 0.00 2.41 ± 0.98 0.00
15.62 μg/ml 80.04 ± 0.50 4.53 ± 0.89 0.00 0.00 0.00
7.8 μg/ml 32.11 ± 0.16 3.85 ± 0.07 0.00 0.00 0.00
3.4 μg/ml 3.70 ± 0.24 0.00 0.00 0.00 0.00
control + 0.00 0.00 0.00 0.00 0.00

NIC 090 NIC 091 NIC 092 NIC 093
250 μg/ml 56.84 ± 0.74 56.28 ± 0.17 58.81 ± 0.79 60.87 ± 1.45
125 μg/ml 40.83 ± 0.06 12.57 ± 0.50 34.51 ± 1.61 14.09 ± 0.46
62,5 μg/ml 17.94 ± 0.31 11.63 ± 0.03 18.06 ± 1.01 4.08 ± 0.89
31,25 μg/ml 13.20 ± 0.46 9.68 ± 0.06 17.22 ± 0.63 0.00
15.62 μg/ml 0.00 1.92 ± 0.35 12.64 ± 1.55 0.00
7.8 μg/ml 0.00 0.00 3.90 ± 0.87 0.00
3.4 μg/ml 0.00 0.00 0.00 0.00
control + 0.00 0.00 0.00 0.00
0.00 0.00 0.00 0.00

JLO 1 JLO 2 JLO 3 JLO 4 JLO 5

250 μg/ml 6.51 ± 0.58 39.51 ± 1.18 100.00 46.12 ± 0.23 23.61 ± 0.82
125 μg/ml 5.50 ± 0.58 3.94 ± 0.74 90.96 ± 1.39 35.66 ± 1.04 19.98 ± 0.53
62,5 μg/ml 0.00 0.00 90.43 ± 1.82 27.72 ± 0.30 10.13 ± 0.23
31,25 μg/ml 0.00 0.00 38.41 ± 0.30 26.20 ± 0.22 8.51 ± 0.36
15.62 μg/ml 0.00 0.00 4.28 ± 0.36 23.52 ± 1.77 0.00
7.8 μg/ml 0.00 0.00 0.00 13.43 ± 0.58 0.00
3.4 μg/ml 0.00 0.00 0.00 8.05 ± 0.88 0.00
control + 0.00 0.00 0.00 0.00 0.00

JLO 6 JLO 7 JLO 8 JLO 9 JLO 10
250 μg/ml 30.33 ± 0.58 26.48 ± 0.50 19.30 ± 0.03 47.01 ± 1.10 81.61 ± 1.46
125 μg/ml 25.06 ± 1.24 23.85 ± 0.16 11.64 ± 0.79 56.85 ± 1.56 70.14 ± 1.53
62,5 μg/ml 11.58 ± 0.65 13.67 ± 0.24 0.00 38.74 ± 0.09 56.26 ± 0.51
31,25 μg/ml 11.36 ± 0.96 7.07 ± 0.40 0.00 36.28 ± 0.97 30.04 ± 1.06
15.62 μg/ml 8.40 ± 0.71 4.42 ± 0.01 0.00 30.87 ± 1.32 29.20 ± 0.16
7.8 μg/ml 7.39 ± 0.44 3.98 ± 0.90 0.00 28.32 ± 0.66 21.86 ± 0.78
3.4 μg/ml 6.77 ± 0.57 0.00 0.00 30.83 ± 0.64 2.40 ± 0.02
control + 0.00 0.00 0.00 0.00 0.00 0.00

EAS 1 EAS 2 EAS 3 EAS 4 EAS 5

250 μg/ml 54.76 ± 0.31 62.19 ± 1.61 56.53 ± 0.65 90.02 ± 0.08 100.00
125 μg/ml 48.41 ± 0.15 53.61 ± 1.52 36.87 ± 0.81 24.79 ± 0.23 60.96 ± 1.81
62,5 μg/ml 27.49 ± 0.27 25.75 ± 0.28 26.83 ± 0.11 24.29 ± 0.30 21.75 ± 1.17
31,25 μg/ml 7.40 ± 0.77 0.00 5.75 ± 0.32 13.76 ± 0.99 13.52 ± 0.98
15.62 μg/ml 5.63 ± 0.32 0.00 0.00 8.37 ± 0.92 11.32 ± 0.82
7.8 μg/ml 1.05 ± 0.91 0.00 0.00 0.00 0.00
3.4 μg/ml 0.00 0.00 0.00 0.00 0.00
control + 0.00 0.00 0.00 0.00 0.00

EAS 6 MIM 1 MIM 2 MIM 3 MIM 4

250 μg/ml 100.00 49.71 ± 0.26 42.69 ± 1.16 47.15 ± 0.18 96.34 ± 0.18
125 μg/ml 62.89 ± 1.54 27.86 ± 0.43 40.85 ± 0.96 46.89 ± 1.94 86.46 ± 1.85
62,5 μg/ml 24.58 ± 0.82 25.56 ± 0.10 30.03 ± 0.68 42.45 ± 1.51 86.02 ± 0.48
31,25 μg/ml 0.00 20.80 ± 0.27 28.53 ± 1.09 27.09 ± 1.08 72.50 ± 0.46
15.62 μg/ml 0.00 18.37 ± 0.33 26.37 ± 1.49 26.90 ± 1.98 63.02 ± 0.39
7.8 μg/ml 0.00 16.16 ± 0.12 14.73 ± 1.14 19.99 ± 0.78 45.13 ± 0.78
3.4 μg/ml 0.00 11.15 ± 0.12 7.24 ± 0.22 0.00 26.06 ± 0.68
control + 0.00 0.00 0.00 0.00 0.00

CR 6 CR 7 CR 8 CR 10 CR 15

250 μg/ml 50.45 ± 0.32 27.97 ± 0.76 29.83 ± 0.62 44.84 ± 0.05 33.75 ± 0.40
125 μg/ml 38.82 ± 0.36 26.88 ± 0.94 28.68 ± 1.47 26.29 ± 1.10 28.81 ± 0.60
62,5 μg/ml 28.45 ± 0.68 21.37 ± 0.43 25.24 ± 1.93 8.94 ± 0.20 17.87 ± 1.37
31,25 μg/ml 20.22 ± 0.22 19.66 ± 0.89 2.48 ± 0.09 2.68 ± 1.50 12.15 ± 0.05
15.62 μg/ml 18.24 ± 0.34 9.51 ± 0.41 0.00 0.00 3.95 ± 0.14
7.8 μg/ml 12.21 ± 0.30 0.00 0.00 0.00 0.00
3.4 μg/ml 0.00 0.00 0.00 0.00 0.00
control + 0.00 0.00 0.00 0.00 0.00
NHPz
CR 22 2NPz sol 3NPz sol 4NPz sol
sol
250 μg/ml 45.14 ± 0.43 100.00 44.69 ± 1.22 57.55 ± 0.91 61.17 ± 0.81
125 μg/ml 17.47 ± 0.46 76.79 ± 0.20 41.75 ± 1.99 26.62 ± 1.63 46.56 ± 0.07
62,5 μg/ml 21.82 ± 1.96 62.90 ± 0.75 29.52 ± 0.01 9.00 ± 1.65 18.86 ± 0.63
31,25 μg/ml 19.33 ± 0.10 45.10 ± 0.78 19.29 ± 0.43 0.00 13.81 ± 0.66
15.62 μg/ml 0.00 22.52 ± 0.87 4.15 ± 0.02 0.00 22.30 ± 0.64
7.8 μg/ml 0.00 4.53 ± 0.97 0.00 0.00 23.07 ± 0.64
3.4 μg/ml 0.00 0.00 0.00 0.00 20.70 ± 0.66
control + 0.00 0.00 0.00 0.00 0.00
MeOA
BrPz sol 3NPipe PhPz sol MeH test
test
250 μg/ml 39.27 ± 0.81 44.05 ± 0.33 52.14 ± 0.34 33.10 ± 1.51 43.04 ± 0.26
125 μg/ml 0.00 41.03 ± 0.05 24.94 ± 0.42 19.12 ± 0.82 29.62 ± 0.30
62,5 μg/ml 0.00 6.06 ± 0.41 10.84 ± 0.08 14.72 ± 1.26 19.02 ± 0.19
31,25 μg/ml 0.00 0.00 2.57 ± 0.03 14.43 ± 0.09 12.71 ± 0.49
15.62 μg/ml 0.00 0.00 0.00 13.75 ± 0.51 0.00
7.8 μg/ml 0.00 0.00 0.00 8.26 ± 0.17 0.00
3.4 μg/ml 0.00 0.00 0.00 5.58 ± 0.92 0.00
control + 0.00 0.00 0.00 0.00 0.00

TABLA 3: % de INH en C.albicans

NAT 1 NAT 2 NAT 3 NAT 4 NAT 21

250 μg/ml 34.27 ± 1.58 32.68 ± 1.48 45.24 ± 0.04 48.00 ± 0.05 9.13 ± 0.53
125 μg/ml 16.30 ± 0.56 22.78 ± 0.13 26.89 ± 0.22 18.45 ± 1.67 7.87 ± 0.49
62,5 μg/ml 8.83 ± 0.05 11.08 ± 0.48 21.55 ± 0.63 5.85 ± 0.29 3.73 ± 0.09
31,25 μg/ml 5.18 ± 0.72 9.47 ± 0.17 8.70 ± 0.18 4.48 ± 0.27 2.07 ± 0.86
15.62 μg/ml 3.36 ± 0.56 5.89 ± 0.33 3.39 ± 0.31 2.93 ± 0.70 1.67 ± 0.44
7.8 μg/ml 2.77 ± 0.07 2.12 ± 0.46 1.18 ± 0.80 1.21 ± 0.76 1.01 ± 0.62
3.4 μg/ml 2.36 ± 0.13 1.70 ± 0.86 0.00 0.68 ± 0.92 0.00
control + 0.00 0.00 0.00 0.00 0.00

NAT 22 NAT 31 NAT 32 NAT 41 NAT 42
250 μg/ml 20.33 ± 1.19 58.40 ± 0.09 100.00 ± 15.63 ± 0.43 60.81 ± 0.97
125 μg/ml 4.13 ± 0.57 18.15 ± 0.26 76.18 ± 1.06 4.45 ± 0.71 17.26 ± 0.96
62,5 μg/ml 2.44 ± 0.13 9.07 ± 0.35 60.02 ± 0.07 1.07 ± 0.03 7.01 ± 0.11
31,25 μg/ml 0.86 ± 0.15 6.79 ± 0.78 13.48 ± 0.18 0.98 ± 0.31 3.27 ± 0.43
15.62 μg/ml 0.22 ± 0.05 4.52 ± 0.27 4.50 ± 0.41 0.00 3.34 ± 0.77
7.8 μg/ml 0.00 1.84 ± 0.30 0.00 0.00 2.66 ± 0.36
3.4 μg/ml 0.00 6.70 ± 0.76 0.00 0.00 2.32 ± 0.74
control + 0.00 0.00 0.00 0.00 0.00

GP 029 GP 045 GP 048 GP 054 GP 055

250 μg/ml 43.19 ± 0.55 12.99 ± 0.64 4.13 ± 0.53 45.64 ± 1.02 41.96 ± 0.87
125 μg/ml 43.83 ± 0.54 9.48 ± 0.97 2.72 ± 0.17 37.14 ± 1.92 24.94 ± 0.76
62,5 μg/ml 35.22 ± 0.22 4.35 ± 0.39 0.61 ± 0.49 31.51 ± 1.26 11.94 ± 0.14
31,25 μg/ml 8.18 ± 0.61 2.22 ± 0.49 0.16 ± 0.11 14.12 ± 0.50 7.21 ± 0.61
15.62 μg/ml 5.24 ± 0.47 4.24 ± 0.80 0.00 10.17 ± 0.17 6.42 ± 0.77
7.8 μg/ml 2.38 ± 0.88 4.45 ± 0.22 0.00 7.75 ± 0.63 4.61 ± 0.43
3.4 μg/ml 0.00 0.00 0.00 3.72 ± 0.51 2.48 ± 0.68
control + 0.00 0.00 0.00 0.00 0.00

GP 056 GP 058 2 AP 4EA POL 3AP 4EA ASMA 25

250 μg/ml 30.75 ± 0.68 30.70 ± 0.76 51.21 ± 0.36 43.61 ± 1.50 32.61 ± 0.91
125 μg/ml 13.51 ± 0.09 15.03 ± 1.64 26.65 ± 0.25 33.22 ± 1.37 13.00 ± 0.68
62,5 μg/ml 9.71 ± 0.72 10.68 ± 0.61 11.14 ± 0.35 19.56 ± 0.28 6.19 ± 0.03
31,25 μg/ml 8.29 ± 0.89 4.90 ± 0.13 4.87 ± 0.03 8.02 ± 0.66 1.52 ± 0.46
15.62 μg/ml 5.38 ± 0.93 4.10 ± 0.82 0.00 6.49 ± 0.58 1.24 ± 0.72
7.8 μg/ml 2.67 ± 0.79 2.90 ± 0.08 0.00 4.60 ± 0.17 0.00
3.4 μg/ml 0.00 1.35 ± 0.03 0.00 3.78 ± 0.45 0.00
control + 0.00 0.00 0.00 0.00 0.00

MJAM NIC 41 NIC 067 NIC 088 NIC 089

250 μg/ml 100.00 2.24 ± 0.60 19.92 ± 0.17 0.00 2.72 ± 0.76
125 μg/ml 84.92 ± 0.03 1.17 ± 0.16 1.28 ± 0.54 0.00 0.00
62,5 μg/ml 40.91 ± 0.94 0.00 0.00 0.00 0.00
31,25 μg/ml 15.45 ± 0.05 0.00 0.00 0.00 0.00
15.62 μg/ml 7.53 ± 0.97 0.00 0.00 0.00 0.00
7.8 μg/ml 3.18 ± 0.07 0.00 0.00 0.00 0.00
3.4 μg/ml 0.95 ± 0.09 0.00 0.00 0.00 0.00
control + 0.00 0.00 0.00 0.00 0.00

NIC 090 NIC 091 NIC 092 NIC 093

250 μg/ml 38.25 ± 1.83 43.99 ± 0.13 43.35 ± 0.33 33.70 ± 0.05
125 μg/ml 17.07 ± 1.09 41.93 ± 0.91 38.52 ± 0.36 18.48 ± 1.77
62,5 μg/ml 10.00 ± 0.75 12.39 ± 0.12 11.74 ± 0.07 16.41 ± 0.34
31,25 μg/ml 3.93 ± 0.03 3.85 ± 0.41 3.77 ± 1.53 2.34 ± 0.04
15.62 μg/ml 2.56 ± 0.01 3.57 ± 0.05 3.08 ± 0.76 7.77 ± 0.36
7.8 μg/ml 1.95 ± 0.31 4.24 ± 0.04 1.51 ± 0.27 1.42 ± 0.38
3.4 μg/ml 1.58 ± 0.24 3.34 ± 0.22 0.64 ± 0.26 0.00
control + 0.00 0.00 0.00 0.00

JLO 1 JLO 2 JLO 3 JLO 4 JLO 5

250 μg/ml 18.27 ± 0.32 10.57 ± 0.96 23.59 ± 0.46 13.81 ± 0.79 20.61 ± 0.77
125 μg/ml 15.02 ± 0.05 6.83 ± 0.06 7.95 ± 0.56 4.92 ± 0.61 9.96 ± 0.22
62,5 μg/ml 9.24 ± 0.13 3.03 ± 0.04 4.42 ± 0.25 2.45 ± 0.94 6.51 ± 0.27
31,25 μg/ml 5.19 ± 0.31 0.00 2.33 ± 0.77 0.71 ± 0.04 2.69 ± 0.73
15.62 μg/ml 4.65 ± 0.17 0.00 1.96 ± 0.59 0.65 ± 0.23 2.33 ± 0.65
7.8 μg/ml 1.91 ± 0.49 0.00 1.92 ± 0.22 0.41 ± 0.06 2.26 ± 0.23
3.4 μg/ml 1.48 ± 0.69 0.00 1.35 ± 0.55 0.00 0.65 ± 0.05
control + 0.00 0.00 0.00 0.00 0.00

JLO 6 JLO 7 JLO 8 JLO 9 JLO 10

250 μg/ml 29.78 ± 1.71 30.82 ± 1.54 17.46 ± 0.04 59.58 ± 0.19 79.99 ± 0.04
125 μg/ml 10.03 ± 0.29 8.92 ± 0.65 5.89 ± 0.41 19.56 ± 1.20 24.23 ± 0.83
62,5 μg/ml 3.04 ± 0.29 3.61 ± 0.77 1.96 ± 0.77 6.34 ± 0.30 9.06 ± 0.54
31,25 μg/ml 2.62 ± 0.51 0.95 ± 0.57 1.11 ± 0.23 1.21 ± 0.21 2.01 ± 0.36
15.62 μg/ml 2.59 ± 0.18 0.29 ± 0.40 0.00 0.84 ± 0.24 1.64 ± 0.04
7.8 μg/ml 1.77 ± 0.47 0.00 0.00 0.65 ± 0.14 0.00
3.4 μg/ml 1.00 ± 0.42 0.00 0.00 0.00 0.00
control + 0.00 0.00 0.00 0.00 0.00

EA 1 EA 2 EA 3 EA 4 EA 5

250 μg/ml 26.82 ± 0.21 14.14 ± 1.62 14.70 ± 0.74 20.38 ± 1.06 100.00
125 μg/ml 5.74 ± 0.64 4.83 ± 0.58 7.87 ± 0.66 11.74 ± 0.82 50.67 ± 0.97
62,5 μg/ml 3.91 ± 0.27 1.41 ± 0.06 7.71 ± 0.45 5.47 ± 0.75 20.03 ± 0.77
31,25 μg/ml 2.99 ± 0.31 0.69 ± 0.31 3.37 ± 0.18 3.80 ± 0.55 4.87 ± 0.20
15.62 μg/ml 2.31 ± 0.34 0.52 ± 0.04 2.71 ± 0.39 2.57 ± 0.85 3.30 ± 0.44
7.8 μg/ml 1.63 ± 0.35 0.00 2.61 ± 0.79 2.14 ± 0.17 2.51 ± 0.36
3.4 μg/ml 1.20 ± 0.24 0.00 2.46 ± 0.34 1.65 ± 0.78 1.24 ± 0.25
control + 0.00 0.00 0.00 0.00 0.00

EA 6 MIM 1 MIM 2 MIM 3 MIM 4

250 μg/ml 75.78 ± 0.75 34.68 ± 1.94 28.91 ± 0.65 37.12 ± 1.70 22.55 ± 0.79
125 μg/ml 24.82 ± 0.29 7.96 ± 0.45 17.98 ± 1.24 29.15 ± 1.36 14.77 ± 1.06
62,5 μg/ml 12.62 ± 0.12 7.29 ± 0.18 10.67 ± 0.13 17.23 ± 1.81 9.30 ± 0.62
31,25 μg/ml 3.88 ± 0.24 3.65 ± 0.16 9.70 ± 0.77 11.41 ± 0.78 4.96 ± 0.24
15.62 μg/ml 3.85 ± 0.49 3.05 ± 0.73 7.24 ± 0.07 9.07 ± 0.76 3.52 ± 0.16
7.8 μg/ml 1.70 ± 0.41 0.72 ± 0.64 2.51 ± 0.14 4.80 ± 0.74 1.58 ± 0.52
3.4 μg/ml 1.70 ± 0.01 0.36 ± 0.48 1.76 ± 0.21 0.00 1.30 ± 0.57
control + 0.00 0.00 0.00 0.00 0.00

CR 6 CR 7 CR 8 CR 10 CR 15

250 μg/ml 50.37 ± 0.67 42.87 ± 0.42 20.83 ± 1.21 43.88 ± 0.74 39.95 ± 1.57
125 μg/ml 23.43 ± 0.81 17.63 ± 1.68 10.32 ± 0.17 21.80 ± 0.04 24.22 ± 0.45
62,5 μg/ml 13.15 ± 0.43 12.81 ± 1.84 4.76 ± 0.55 13.31 ± 0.98 13.13 ± 0.48
31,25 μg/ml 4.09 ± 0.82 5.38 ± 0.16 4.24 ± 1.64 7.84 ± 0.04 6.32 ± 0.21
15.62 μg/ml 2.39 ± 0.92 4.65 ± 0.19 2.86 ± 0.02 6.95 ± 0.14 4.77 ± 0.18
7.8 μg/ml 0.00 4.44 ± 0.44 2.32 ± 0.55 5.01 ± 0.10 3.93 ± 0.48
3.4 μg/ml 0.00 4.00 ± 0.35 2.23 ± 0.82 0.00 2.24 ± 0.44
control + 0.00 0.00 0.00 0.00 0.00
4NPz
CR 22 NHPz sol 2NPPz sol 3NPz sol
sol
250 μg/ml 41.89 ± 0.36 100.00 86.78 ± 0.05 9.86 ± 0.42 11.80 ± 1.09
125 μg/ml 37.04 ± 0.91 100.00 55.54 ± 1.94 6.67 ± 0.33 5.18 ± 0.33
62,5 μg/ml 22.01 ± 1.48 100.00 31.01 ± 0.67 0.00 4.33 ± 0.33
31,25 μg/ml 11.78 ± 0.70 54.33 ± 0.08 13.08 ± 1.00 0.00 2.51 ± 0.59
15.62 μg/ml 7.50 ± 0.38 20.02 ± 1.75 7.07 ± 0.37 0.00 0.47 ± 0.21
7.8 μg/ml 5.23 ± 0.16 10.02 ± 0.15 5.10 ± 0.54 0.00 0.00
3.4 μg/ml 2.02 ± 0.15 2.35 ± 0.18 0.00 0.00 0.00
control + 0.00 0.00 0.00 0.00 0.00
MeH
BrPz sol 3NPipe PhPz sol MeOA test
test
250 μg/ml 4.72 ± 0.29 10.34 ± 0.04 33.65 ± 0.63 45.75 ± 1.45 21.61 ± 0.64
125 μg/ml 2.20 ± 0.17 8.31 ± 0.80 20.79 ± 0.84 37.24 ± 0.47 15.54 ± 0.12
62,5 μg/ml 1.40 ± 0.39 6.38 ± 0.03 14.63 ± 1.45 21.00 ± 0.07 12.34 ± 0.99
31,25 μg/ml 1.32 ± 0.51 0.79 ± 0.01 5.26 ± 0.97 12.29 ± 0.41 9.33 ± 0.11
15.62 μg/ml 0.87 ± 0.51 0.00 4.77 ± 0.45 7.59 ± 1.23 9.27 ± 0.69
7.8 μg/ml 0.00 0.00 4.53 ± 0.68 6.32 ± 1.39 7.74 ± 0.62
3.4 μg/ml 0.00 0.00 2.27 ± 0.60 2.35 ± 0.58 7.32 ± 0.88
control + 0.00 0.00 0.00 0.00 0.00