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BIOCHEMICAL PATHWAYS:
An Atlas of Biochemistry and
Molecular Biology
Second Edition

Edited by
Gerhard Michal
Dietmar Schomburg

@WILEY
A JOHN WILEY & SONS, INC, PUBLICATION

7.6 Leucine.2 From Nucleic Acids to Proteins -The Genetic Code 30 3.10 Lipid Aggregates and Membranes 35 l.7 Steroids 8 Robbe Wiinschiers 1.2 Carbohydrate Chemistry and Structure 4 1.3 Multienzyme Complexes 23 Robbe Wiinschiers 2.5.5 Steroids and Isoprenoids 107 2.5 Plasmalogens 7 1. Cysteine and 1.2.5.5. 1.1 Catalytic Mechanism 21 3.1.5.9 BileAcids 121 .2.3 .5.2 Triacylglycerols (Triglycerides) 98 3.4.4.2 Hopanoids.1 Carbohydrate Metabolism and Citrate Cycle 37 1.4.1.7.2.2 Glutamate.3.9 Glycosylated Proteins and Peptides 32 ~.5.2 Glycosidic Bonds 5 Robbe Wiinschiers 1.1 Fatty Acids and Acyl-CoA 93 2.4.3 Influence of Errors 31 3.3.5.4 Glycolipids 104 2.4.3 Site of Regulation 26 Robbe Wiinschiers 2.2 Properties of RNA Chains 27 Insects 110 2.4 Serine and Glycine 62 1.2.5 Classification of Enzymes 23 3.3 Isoprenoids Ill 2.9 Urea Cycle.5. Threonine.1 Classification of Living Organisms 14 Reactions 80 2.6.1 Structure and Classification 6 3.7 Genetic Code and the Flow of Information 30 3.3 Phospholipids 100 2.1 Pathways for the Biosynthesis of 2.4 Reaction Rate 23 3.7 Amino Sugars 54 1.1 Levels of Organization 19 3.6.4 Enzymes 21 3.> v Contents Preface to the Second Edition IX 2.4.8.8 Polymeric Carbohydrates 31 From the Preface to the First Edition X 2.1.3.1 From DNA to RNA 30 3.3 Tetrapyrroles 82 2.1 Energetics of Chemical Reactions 8 3.2.3 Waxes 7 3.and Oligosaccharides 48 1.2 Polymeric Carbohydrates as Structural Elements 32 Contributors XI .3 Special Structures of Plant Cells 17 3.3 Protein Structure and Function 18 3.5 Metabolism of Hexose Derivatives 48 1.3.5 Physico-Chemical Aspects of Biochemical Processess 8 Ammonia Turnover 59 1.3 Transport Through Membranes 9 3..2 General Characteristics of Eukaryotic Cells 15 Martina Jahn and Dieter Jahn 2. Asparagine and 1.6.1 Glycoproteins 33 1 Introduction and General Aspects 1 .2.8 Corticosteroids 119 2.4.1 Structure and Classification 4 3.4 Special Structures of Animal Cells 18 Tetrapyrroles 82 3. 1 Components of Nucleic Acids 26 3.4.2.2.8 Citrate Cycle 55 1.2.8 Lipoproteins 8 3.4 Steroid Hormones 114 3.8.5.3. Alanine. 219.5.8 Histidine 79 3. 2.4.2.1 Glycolysis and Gluconeogenesis 37 1.1 Fatty acids 6 3.6 Androgens 116 2.2 Heme and Cytochrome Biosynthesis 86 2. Steroids of Plants and 2.4.1.2 Redox Reactions 9 3.1.2.2 Acylglycerols and Derivatives 7 3.4.3.1 Cholesterol 107 2.4.9 Glyoxylate Metabolism 57 1.4 Compaction Levels of DNA Chains 28 3. Tryptophan and 2 The Cell and Its Contents 14 Derivatives 74 Gerhard Michal and Dietmar Schomburg 3.l.2 Common Abbreviations 3 3 Metabolism 37 1.1.9.2 Regulation of the Activity of Enzymes 24 3. Methionine.3 Peptidoglycans 35 1.4 Lipids and Glycolipids 93 2.4.7. Arginine and Associated 2.5 Regulation of the Enzyme Activity 24 3.2.1 Organization of This Book 2.2. Glutamine.4 Biosynthesis of Chlorophylls 90 2..6 Sphingolipids 7 3. Isoleucine and Valine 72 3.5 .1.1 Regulation of the Quantity of Enzymes 24 2.1.2.2 Proteoglycans 33 Gerhard Michal and Dietmar Schomburg .4.4 Lipid Chemistry and Structure 6 3.5. Aspartate.4.4 Di.3 Proline and Hydroxyproline 62 1.2 Polysaccharide Metabolism 42 1.4 Enzyme Kinetics 10 Sulfur Metabolism 65 3.3 Amino Acid Chemistry and Structure 5 3.3.l Conventions Used in This Book 3 .6 Pentose Metabolism 51 1.7 Estrogens 117 2.2.3 Linear Tetrapyrroles 87 2.6 Nucleic Acid Structure 26 3.5.1. Tyrosine.2 Structure of Cells 14 2.5 Gestagen 115 2.1.3 Pyruvate Turnover and Acetyl-Coenzyme A 46 3. ' '"2.3 Properties of DNA Chains 27 3.2 Protein Function 21 3.1 Polymeric Carbohydrates in Energy Storage 31 2.5 Lysine.6.2 Isoenzymes 23 2.5.1 Prokaryotic Cells 14 3.4 Glycerophospholipids 7 3.· 2:9.5 .2 Amino Acids and Derivatives 58 1.4.3.7 Phenylalanine.1 Nitrogen Fixation and Metabolism 58 3.5.5 Biosynthesis of Cobalamins 91 2.3.6 Siroheme Biosynthesis 91 2.2 Peptide Bonds 6 3.4.

11 Electron Transfer Reactions and Oxidative 5.11.1 Hepatitis C Virus 267 3.3 Degradation of Nucleic Acids 156 4 .10.10.4.4 Pyridoxine (Vitamin B6) 136 4 .1 Protein Processing in the Endoplasmic Reticulum 238 3.7.2 Pyrimidine Nucleotides and Nucleosides 130 Robbe Wunschiers 3. Vitamin B 12) 137 Stefan Ries 3.2 Protein Biosynthesis in Eukarya 219 3.2 Differenuypes of elcctmn transport chains 183 5.1 0.2 Bacterin! Protein Export across the Cytoplasmic Membrane 166 3.8 Biotin 141 4. to M Tmn ilion in Manuuolian Cells 235 3.2.2.1.9 Nucleic Acid Metabolism in Eukarya 157 Petra Dersch Helmut Burtscher 4.8.1 Transport Through Membranes 272 3.3.7.4 Degradation of Nucleic Acids 217 3.6 Protein Degradation 256 Julia Garbe.3.14 Other Compounds 149 Robbe Wiinschiers 4.6 Anaerobic Respiration 173 5.3.1 Bacterial Envelope 164 System 258 3.1 Protein Synthesis in Bacteria 210 6.5.4.10.4 G.11 Calciferol (Vitamin D) 146 4.7.7.13.1 Retinol (Vitamin A) 133 4.2. Alkane and Methane Oxidation 178 5.1.3 Protein Transport acros the Outer Membrane of Gram-Negative Bacteria 167 5 Viruses 261 3.13 Plant Secondary Metabolism 193 Channels/Pores 272 6.3 RNA Viruses 267 5.11.1 Human Immunodeficiency Virus (HIV) 268 3.5.10 Special Bacterial Metabolism and Biosynthesis of 4.2 Bacterial DNA Repair 151 3.13.13.6.10.3 Eukaryotic Translation 228 3.10 Ascorbate (Vitamin C) 145 4.1.1 Phenolics 194 6.1.5 M.6 The Cytoskeleton as Mean for Intracellular Transport and Cellular Movement in Eu karya 27 4 Protein Biosynthesis.1.2. Transport/Targeting and Degradation 244 3. NAD+ and NADP+ 143 4.7.9.4 Protein Transport into Mitochondria 252 3.3 Bacterial Protein Synthesis 214 Robbe Wunschiers 4.2.3 Protein Transport into the Nucleus 249 4.5.5.8.8 Quinoenzymes.1 General Characteristics of Viruses 261 3.2 Regulation of Bacterial Gene Expression 212 6.2 Thiamin (Vitamin B.7 Pantothenate.3 Solute Carriers 276 3.11.3 Riboflavin (Vitamin B2) .1.12 Photosynthesis 188 6 Transport 272 Dieter Oesterhelt and Josef Wachtveitl 3.1 Core Components of the Cell Cycle Machinery 232 Protein (ACP) 141 4.6 Cell Cycle Checkpoints 236 3.8 Nucleic Acid Metabolism in Bacteria 149 4.7 Cofactors and Vitamins 133 4.2 Cell Cycle Regulation in Yeast 234 3.VI Contents 3.itosi in Mammalian Cell 235 3.4.4 Retroviruses 268 3.5 Bacterial Fermentations 169 3.1.7.5 .7.2.1.2 Terpenoids 198 6.1 Genomic Characteristics of Viruses 261 3.2 Transport of Lipids in Plasma 279 Degradation 210 Horst Klima 6.7 Protein Degradation by the Ubiquitin-Proteasome 3.4 Bacterial Transport Systems 168 Klaus Klumpp 3.1 LightReaction 188 6.10.1.3 Lipid Transport Proteins 281 4. Annika Steen and Max Schobert 4.5 Protein Transport into Chloroplasts 254 Antimicrobials 164 4.5.9 Antibiotics 179 5.1 Eukaryotic DNA Replication 157 4.2 Vesicular Transport and Secretion of Proteins 248 3. Coenzyme A and Acyl Carrier 4.6 Folate and Pterines 138 3.1 Papillomavirus 264 Phosphorylation 183 Martina Jahn and Dieter Jahn 5.7.6 Nucleotides and Nucleosides 124 4.9 Nicotinate.2 Regulation of Eukaryotic Transcription 226 4.3.1 Bacterial DNA Replication 149 Glycoconjugates 243 3.10.) 134 4.7.11.1 Folding of Proteins 244 3.7. to S Trao ition in Mammalian Cells 234 3.13 Phylloquinone and Menaquinone (Vitamin K) 148 4.1 Bacterial Transcription 210 6.10.4 Translational Regulation 231 3. 278 3.1 Apolipoproteins (Apo) 279 4.2.7.6.5 Protein Folding.3.1 Eukaryotic Transcription 219 Ida Schomburg 4.7 .2 Eukaryotic DNA Repair 162 4.2 Glycosylation Reactions in the Golgi Apparatus 241 Susanne Peifer and Elmar Heinzle 4.7 Chemolithotrophy 175 5.2 Plasma Lipoprotein Metabolism 279 Martina Jahn and Dieter Jahn 6. Modifications and 6.4 Lipoprotein Receptors 281 4.12 Tocopherol (Vitamin E) 148 3.3 Nitrogen-containing Secondary Metabolites 201 6.3 Cell Cycle in Eukarya 232 3.9.5.2 Antje Chang 6.7.3 Terminal Carbohydrate Structures of 3.1.2.1 General Principles 183 3.1.10.1 Purine Nucleotides and Nucleosides 124 4 .4.3 The Energetic Basis of the Oxidativ e Phosphorylation 183 5.1.2 DNA Viruses 264 3.2.7.5 Import by Endocyto i and Pinocytosi.8.2.5 mRNA Degradation 231 3.3.2 Structure 263 3.5 Cobalamin (Coenzyme B 12 . FMN and FAD 135 3.4 Posttranslational Modification of Proteins 238 3.12.2 DarkReactions 192 Wilhelm Just 6.4 Primary Active Transport ystems 277 3.4 Electron 'fran port Sy rem in Mitochondria and Bacteria 184 3.3.3 G.12.2.5 Lipid Metabolic Disorders 282 .1 Systems of Eukaryotic Membrane Passage 272 3.

3 Protein Kinase G 323 10.3 Oxygen Transport by Hemoglobin 282 8.5 Postsynaptic Receptors 296 7.3 Receptor Tyrosine Kinases 312 7.1.2.3.2.4 Epinephrine and Norepinephrine (Catecholamines) 287 8.2.5 Cellular Cytotoxicity and Apoptosis 347 7.4 Lymphocyte Circulation and Generation of Cellular and 7.8.3 Hemoglobin Diseases in Humans 285 8.2 Initial Reactions 35 8 7.4 Antigen Receptor of B Lymphocytes.4.8 Hormones Regulating the Na• Concentration and the Water Pathogens 35 I Balance 292 7.1.4 Voltage Gated Signalling at the Synapse 296 Anton Haselbeck 7.6 Visual Process 307 7.2 cAMP Metabolism.8. Regulation of the Immune 7.8 Cyclic GMP Dependent Pathways and Effects of 10 Biochemical Networks. 6.4.1 Reactions Initiated by the Tissue Factor 358 7.2.2 Oxygen Binding to Hemo.3 Pathologic Immune responses 352 8.5.2.1.3 Activation of Phospholipase C and Protein Kinase C 302 9.3.3.2.3 Key Events 359 7.3.2 Components of the Signal Cascades 311 9.8 Cytokines.8.5 Hypothalamus-Anterior Pituitary Hormone System 287 8.2 Control of Fibrinolysis 365 Retinoids and Vitamin D 321 7.3 Generation of Binding Surfaces 358 7. Bioinformatics and Systems Nitric Oxide (NO) 322 Biology 366 7.2.4.3.3 Development and Maturation of the Cellular Contents VII Gerhard Michal Components 328 8.1 IgE-Mediated Hypersensitivity of the 7.2 Nerve Conduction and Synaptic Transmission 294 Immediate Type 352 7.4.1.5.1 Mechanism of Heterotrimeric G-Protein Action 300 9.6 Placental Hormones 291 Neuroendocrine System 350 7.2 Pathways Leading to Thrombin 359 7.1 Membrane Bound Guanylate Cyclases 323 Dietmar Schomburg 7.1 Intercellular Signal Transmission by Hormones 286 Response 344 7.3 Activation ofB Cells 345 7.2.6 Interactions between the Immune System and the 7.2 Detailed Description of Some Databases 367 8.8 Induction of Specific Immune Responses against 7.1 Requirements for Protease Activity 359 9.4 Metabolic Role ofinositol Phosphates and Ca++ 303 9.5 Generation of Fibrin 361 7.4 Controlled Propagation 360 7.2 CD4+ T Effector Cells.3.3 Insulin and Glucagon 287 Humoral Immune Responses in Lymphoid Tissue 345 7.5 Complement System 334 6.3.3.2.2.1. for 9. Chemokines and Receptors 338 7 Signal Transduction and Cellular 8.5 Fibrinolysis 364 9.3.7 Receptors for Steroid and Thyroid Hormones.3.3.2.7 Hormones Regulating the Extracellular Ca++.2.1 Overview 366 8.1.4.1 Regulatory Factors for Cell Growth and Function 311 9.5.3 Principles of Intracellular Communication 296 9 Blood Coagulation and Fibrinolysis 357 Peter Muller 7.1.7 Olfactory and Gustatory Processes 308 9.1 Innate.5.1 Pathways of Plasminogen Activation 364 7.1.1.2.2 Specific.7 Antigen Presentation by MHC Molecules 337 8.4 Adhesion of Leukocytes 354 7.9 Hormones of the Gastrointestinal Tract 293 8.1. Non Adaptive Immune System 325 8.3 Biochemical Pathways Information Ernst Peter Rieber Resources 366 10.1.1 Components of the Immune System 325 10.2 General Characteristics of Receptors 286 8..5. Adaptive Immune System 328 Index 374 .2.5 Receptors Acting Through Tyrosine Kinases 311 9.1.2.2.3 Coagulation Propagation and Control 359 7.5.1 Activation ofT Cells 343 8.4 Platelets (Thrombocytes) 362 7. Mg++ and 8.1.1.1 Hemostasis 357 7.6 Antigen Receptor ofT Lymphocytes 336 6.1.1 General Characteristics of Hormones 286 8.2. Tyrosine Kinase-Associated Receptors (TKaR) 315 9.8 Arachidonate Metabolism and Eicosanoids 309 9.1 Membrane Potential 294 8.4.7 Immunological Tolerance 350 Phosphate Concentrations 292 8. 6.and Myoglobin 283 8.4. Activation of Adenylate Cyclase and Protein Kinase A 302 9.2 Generation of a Specific Immune Communication 286 Response 343 Gerhard Niederfellner 8.2 Soluble Guanylate Cyclases and Their Activation by Nitric Oxide (NO) 323 10.1 Systems Biology and Networks 366 7.1.3 Transmitter Gated Signalling at the Synapse 294 8.2 Modeling of Metabolic Fluxes 366 8 Immune System 325 10.2 Conduction of the Action Potential along the Axon 294 7.6 Axonal Transport 296 7.3.1 Biosynthesis and Properties of Hemoglobin and Antibodies 330 Myoglobin 282 8.2 Autoimmunity 353 7.4.5 Muscle Contraction 305 9.2 Contact Activation 358 7.1.4 Receptors Coupled to Heterotrimeric G-Proteins 299 7.4.6 Programmed Cell Death (Apoptosis) 319 9.

Related Interests

BIOCHEMICAL PATHWAYS:
An Atlas of Biochemistry and
Molecular Biology
Second Edition

Edited by
Gerhard Michal
Dietmar Schomburg

@WILEY
A JOHN WILEY & SONS, INC, PUBLICATION

7.6 Leucine.2 From Nucleic Acids to Proteins -The Genetic Code 30 3.10 Lipid Aggregates and Membranes 35 l.7 Steroids 8 Robbe Wiinschiers 1.2 Carbohydrate Chemistry and Structure 4 1.3 Multienzyme Complexes 23 Robbe Wiinschiers 2.5.5 Steroids and Isoprenoids 107 2.5 Plasmalogens 7 1. Cysteine and 1.2.5.5. 1.1 Catalytic Mechanism 21 3.1.5.9 BileAcids 121 .2.3 .5.2 Triacylglycerols (Triglycerides) 98 3.4.4.2 Hopanoids.1 Carbohydrate Metabolism and Citrate Cycle 37 1.4.1.7.2.2 Glutamate.3.9 Glycosylated Proteins and Peptides 32 ~.5.2 Glycosidic Bonds 5 Robbe Wiinschiers 1.1 Fatty Acids and Acyl-CoA 93 2.4.3 Influence of Errors 31 3.3.5.4 Glycolipids 104 2.4.3 Site of Regulation 26 Robbe Wiinschiers 2.2 Properties of RNA Chains 27 Insects 110 2.4 Serine and Glycine 62 1.2.5 Classification of Enzymes 23 3.3 Isoprenoids Ill 2.9 Urea Cycle.5. Threonine.1 Classification of Living Organisms 14 Reactions 80 2.6.1 Structure and Classification 6 3.7 Genetic Code and the Flow of Information 30 3.3 Phospholipids 100 2.1 Pathways for the Biosynthesis of 2.4 Reaction Rate 23 3.7 Amino Sugars 54 1.1 Levels of Organization 19 3.6.4 Enzymes 21 3.> v Contents Preface to the Second Edition IX 2.4.8.8 Polymeric Carbohydrates 31 From the Preface to the First Edition X 2.1.3.1 From DNA to RNA 30 3.3 Tetrapyrroles 82 2.1 Energetics of Chemical Reactions 8 3.2.3 Waxes 7 3.and Oligosaccharides 48 1.2 Polymeric Carbohydrates as Structural Elements 32 Contributors XI .3 Special Structures of Plant Cells 17 3.3 Protein Structure and Function 18 3.5 Metabolism of Hexose Derivatives 48 1.3.5 Physico-Chemical Aspects of Biochemical Processess 8 Ammonia Turnover 59 1.3 Transport Through Membranes 9 3..2 General Characteristics of Eukaryotic Cells 15 Martina Jahn and Dieter Jahn 2. Asparagine and 1.6.1 Glycoproteins 33 1 Introduction and General Aspects 1 .2.8 Corticosteroids 119 2.4.1 Structure and Classification 4 3.4 Special Structures of Animal Cells 18 Tetrapyrroles 82 3. 1 Components of Nucleic Acids 26 3.4.2.2.8 Citrate Cycle 55 1.2.8 Lipoproteins 8 3.4 Steroid Hormones 114 3.8.5.3. Alanine. 219.5.8 Histidine 79 3. 2.4.2.1 Glycolysis and Gluconeogenesis 37 1.1 Fatty acids 6 3.6 Androgens 116 2.2 Heme and Cytochrome Biosynthesis 86 2. Steroids of Plants and 2.4.1.2 Redox Reactions 9 3.1.2.2 Acylglycerols and Derivatives 7 3.4.3.1 Cholesterol 107 2.4.9 Glyoxylate Metabolism 57 1.4 Compaction Levels of DNA Chains 28 3. Tryptophan and 2 The Cell and Its Contents 14 Derivatives 74 Gerhard Michal and Dietmar Schomburg 3.l.2 Common Abbreviations 3 3 Metabolism 37 1.1.9.2 Regulation of the Activity of Enzymes 24 3. Methionine.3 Peptidoglycans 35 1.4 Lipids and Glycolipids 93 2.4.7. Arginine and Associated 2.5 Regulation of the Enzyme Activity 24 3.2.1 Organization of This Book 2.2. Glutamine.4 Biosynthesis of Chlorophylls 90 2..6 Sphingolipids 7 3. Isoleucine and Valine 72 3.5 .1.1 Regulation of the Quantity of Enzymes 24 2.1.2.2 Proteoglycans 33 Gerhard Michal and Dietmar Schomburg .4.4 Lipid Chemistry and Structure 6 3.5. Aspartate.4.4 Di.3 Proline and Hydroxyproline 62 1.2 Polysaccharide Metabolism 42 1.4 Enzyme Kinetics 10 Sulfur Metabolism 65 3.3 Amino Acid Chemistry and Structure 5 3.3.l Conventions Used in This Book 3 .6 Pentose Metabolism 51 1.7 Estrogens 117 2.2.3 Linear Tetrapyrroles 87 2.6 Nucleic Acid Structure 26 3.5.1. Tyrosine.2 Structure of Cells 14 2.5 Gestagen 115 2.1.3 Pyruvate Turnover and Acetyl-Coenzyme A 46 3. ' '"2.3 Properties of DNA Chains 27 3.2 Protein Function 21 3.1 Polymeric Carbohydrates in Energy Storage 31 2.5 Lysine.6.2 Isoenzymes 23 2.5.1 Prokaryotic Cells 14 3.4 Glycerophospholipids 7 3.· 2:9.5 .2 Amino Acids and Derivatives 58 1.4.3.7 Phenylalanine.1 Nitrogen Fixation and Metabolism 58 3.5.5 Biosynthesis of Cobalamins 91 2.3.6 Siroheme Biosynthesis 91 2.2 Peptide Bonds 6 3.4.

11 Electron Transfer Reactions and Oxidative 5.11.1 Hepatitis C Virus 267 3.3 Degradation of Nucleic Acids 156 4 .10.10.4.4 Pyridoxine (Vitamin B6) 136 4 .1 Protein Processing in the Endoplasmic Reticulum 238 3.7.2 Pyrimidine Nucleotides and Nucleosides 130 Robbe Wunschiers 3. Vitamin B 12) 137 Stefan Ries 3.2 Protein Biosynthesis in Eukarya 219 3.2 Differenuypes of elcctmn transport chains 183 5.1 0.2 Bacterin! Protein Export across the Cytoplasmic Membrane 166 3.8 Biotin 141 4. to M Tmn ilion in Manuuolian Cells 235 3.2.2.1.9 Nucleic Acid Metabolism in Eukarya 157 Petra Dersch Helmut Burtscher 4.8.1 Transport Through Membranes 272 3.3.7.4 Degradation of Nucleic Acids 217 3.6 Protein Degradation 256 Julia Garbe.3.14 Other Compounds 149 Robbe Wiinschiers 4.6 Anaerobic Respiration 173 5.3.1 Bacterial Envelope 164 System 258 3.1 Protein Synthesis in Bacteria 210 6.5.4.10.4 G.11 Calciferol (Vitamin D) 146 4.7.7.13.1 Retinol (Vitamin A) 133 4.2. Alkane and Methane Oxidation 178 5.1.3 Protein Transport acros the Outer Membrane of Gram-Negative Bacteria 167 5 Viruses 261 3.13 Plant Secondary Metabolism 193 Channels/Pores 272 6.3 RNA Viruses 267 5.11.1 Human Immunodeficiency Virus (HIV) 268 3.5.10 Special Bacterial Metabolism and Biosynthesis of 4.2 Bacterial DNA Repair 151 3.13.13.6.10.3 Eukaryotic Translation 228 3.10 Ascorbate (Vitamin C) 145 4.1.1 Phenolics 194 6.1.5 M.6 The Cytoskeleton as Mean for Intracellular Transport and Cellular Movement in Eu karya 27 4 Protein Biosynthesis.1.2. Transport/Targeting and Degradation 244 3. NAD+ and NADP+ 143 4.7.9.4 Protein Transport into Mitochondria 252 3.3 Bacterial Protein Synthesis 214 Robbe Wunschiers 4.2.3 Protein Transport into the Nucleus 249 4.5.5.8.8 Quinoenzymes.1 General Characteristics of Viruses 261 3.2 Regulation of Bacterial Gene Expression 212 6.2 Thiamin (Vitamin B.7 Pantothenate.3 Solute Carriers 276 3.11.3 Riboflavin (Vitamin B2) .1.12 Photosynthesis 188 6 Transport 272 Dieter Oesterhelt and Josef Wachtveitl 3.1 Core Components of the Cell Cycle Machinery 232 Protein (ACP) 141 4.6 Cell Cycle Checkpoints 236 3.8 Nucleic Acid Metabolism in Bacteria 149 4.7 Cofactors and Vitamins 133 4.2 Cell Cycle Regulation in Yeast 234 3.VI Contents 3.itosi in Mammalian Cell 235 3.4.4 Retroviruses 268 3.5 Bacterial Fermentations 169 3.1.7.5 .7.2.1.2 Terpenoids 198 6.1 Genomic Characteristics of Viruses 261 3.2 Transport of Lipids in Plasma 279 Degradation 210 Horst Klima 6.7 Protein Degradation by the Ubiquitin-Proteasome 3.4 Bacterial Transport Systems 168 Klaus Klumpp 3.1 LightReaction 188 6.10.1.3 Lipid Transport Proteins 281 4. Annika Steen and Max Schobert 4.5 Protein Transport into Chloroplasts 254 Antimicrobials 164 4.5.9 Antibiotics 179 5.1 Eukaryotic DNA Replication 157 4.2 Vesicular Transport and Secretion of Proteins 248 3. Coenzyme A and Acyl Carrier 4.6 Folate and Pterines 138 3.1 Papillomavirus 264 Phosphorylation 183 Martina Jahn and Dieter Jahn 5.7.6 Nucleotides and Nucleosides 124 4.9 Nicotinate.2 Regulation of Eukaryotic Transcription 226 4.3.1 Bacterial DNA Replication 149 Glycoconjugates 243 3.10.) 134 4.7.11.1 Folding of Proteins 244 3.7. to S Trao ition in Mammalian Cells 234 3.13 Phylloquinone and Menaquinone (Vitamin K) 148 4.1 Bacterial Transcription 210 6.10.4 Translational Regulation 231 3. 278 3.1 Apolipoproteins (Apo) 279 4.2.7.6.5 Protein Folding.3.1 Eukaryotic Transcription 219 Ida Schomburg 4.7 .2 Eukaryotic DNA Repair 162 4.2 Glycosylation Reactions in the Golgi Apparatus 241 Susanne Peifer and Elmar Heinzle 4.7 Chemolithotrophy 175 5.2 Plasma Lipoprotein Metabolism 279 Martina Jahn and Dieter Jahn 6. Modifications and 6.4 Lipoprotein Receptors 281 4.12 Tocopherol (Vitamin E) 148 3.3 Nitrogen-containing Secondary Metabolites 201 6.3 Cell Cycle in Eukarya 232 3.9.5.2 Antje Chang 6.7.3 Terminal Carbohydrate Structures of 3.1.2.1 General Principles 183 3.1.10.1 Purine Nucleotides and Nucleosides 124 4 .4.3 The Energetic Basis of the Oxidativ e Phosphorylation 183 5.1.2 DNA Viruses 264 3.2.7.5 Import by Endocyto i and Pinocytosi.8.2.5 mRNA Degradation 231 3.3.2 Structure 263 3.5 Cobalamin (Coenzyme B 12 . FMN and FAD 135 3.4 Posttranslational Modification of Proteins 238 3.12.2 DarkReactions 192 Wilhelm Just 6.4 Primary Active Transport ystems 277 3.4 Electron 'fran port Sy rem in Mitochondria and Bacteria 184 3.3.3 G.12.2.5 Lipid Metabolic Disorders 282 .1 Systems of Eukaryotic Membrane Passage 272 3.

3 Protein Kinase G 323 10.3 Oxygen Transport by Hemoglobin 282 8.5 Postsynaptic Receptors 296 7.3 Receptor Tyrosine Kinases 312 7.1.2.3.2.4 Epinephrine and Norepinephrine (Catecholamines) 287 8.2.5 Cellular Cytotoxicity and Apoptosis 347 7.4 Lymphocyte Circulation and Generation of Cellular and 7.8.3 Hemoglobin Diseases in Humans 285 8.2 Initial Reactions 35 8 7.4 Antigen Receptor of B Lymphocytes.4.8 Hormones Regulating the Na• Concentration and the Water Pathogens 35 I Balance 292 7.1.4 Voltage Gated Signalling at the Synapse 296 Anton Haselbeck 7.6 Visual Process 307 7.2 cAMP Metabolism.8. Regulation of the Immune 7.8 Cyclic GMP Dependent Pathways and Effects of 10 Biochemical Networks. 6.4.1 Reactions Initiated by the Tissue Factor 358 7.2.2 Oxygen Binding to Hemo.3 Pathologic Immune responses 352 8.5.2.1.3 Activation of Phospholipase C and Protein Kinase C 302 9.3.3.2.3 Key Events 359 7.3.2 Components of the Signal Cascades 311 9.8 Cytokines.8.5 Hypothalamus-Anterior Pituitary Hormone System 287 8.2 Control of Fibrinolysis 365 Retinoids and Vitamin D 321 7.3 Generation of Binding Surfaces 358 7. Bioinformatics and Systems Nitric Oxide (NO) 322 Biology 366 7.2.4.3.3 Development and Maturation of the Cellular Contents VII Gerhard Michal Components 328 8.1 IgE-Mediated Hypersensitivity of the 7.2 Nerve Conduction and Synaptic Transmission 294 Immediate Type 352 7.4.1.5.1 Mechanism of Heterotrimeric G-Protein Action 300 9.6 Placental Hormones 291 Neuroendocrine System 350 7.2 Pathways Leading to Thrombin 359 7.1 Membrane Bound Guanylate Cyclases 323 Dietmar Schomburg 7.1 Intercellular Signal Transmission by Hormones 286 Response 344 7.3 Activation ofB Cells 345 7.2.6 Interactions between the Immune System and the 7.2 Detailed Description of Some Databases 367 8.8 Induction of Specific Immune Responses against 7.1 Requirements for Protease Activity 359 9.4 Metabolic Role ofinositol Phosphates and Ca++ 303 9.5 Generation of Fibrin 361 7.4 Controlled Propagation 360 7.2 CD4+ T Effector Cells.3.3 Insulin and Glucagon 287 Humoral Immune Responses in Lymphoid Tissue 345 7.5 Complement System 334 6.3.3.2.2.1. for 9. Chemokines and Receptors 338 7 Signal Transduction and Cellular 8.5 Fibrinolysis 364 9.3.7 Receptors for Steroid and Thyroid Hormones.3.3.2.7 Hormones Regulating the Extracellular Ca++.2.1 Overview 366 8.1.4.1 Regulatory Factors for Cell Growth and Function 311 9.5.3 Principles of Intracellular Communication 296 9 Blood Coagulation and Fibrinolysis 357 Peter Muller 7.1.7 Olfactory and Gustatory Processes 308 9.1 Innate.5.1 Pathways of Plasminogen Activation 364 7.1.1.2.2 Specific.7 Antigen Presentation by MHC Molecules 337 8.4 Adhesion of Leukocytes 354 7.9 Hormones of the Gastrointestinal Tract 293 8.1. Non Adaptive Immune System 325 8.3 Biochemical Pathways Information Ernst Peter Rieber Resources 366 10.1.1 Components of the Immune System 325 10.2 General Characteristics of Receptors 286 8..5. Adaptive Immune System 328 Index 374 .2.5 Receptors Acting Through Tyrosine Kinases 311 9.1.2.2.3 Coagulation Propagation and Control 359 7.5.1 Activation ofT Cells 343 8.4 Platelets (Thrombocytes) 362 7. Mg++ and 8.1.1.1 Hemostasis 357 7.6 Antigen Receptor ofT Lymphocytes 336 6.1.1 General Characteristics of Hormones 286 8.2. Tyrosine Kinase-Associated Receptors (TKaR) 315 9.8 Arachidonate Metabolism and Eicosanoids 309 9.1 Membrane Potential 294 8.4.7 Immunological Tolerance 350 Phosphate Concentrations 292 8. 6.and Myoglobin 283 8.4. Activation of Adenylate Cyclase and Protein Kinase A 302 9.2 Generation of a Specific Immune Communication 286 Response 343 Gerhard Niederfellner 8.2 Soluble Guanylate Cyclases and Their Activation by Nitric Oxide (NO) 323 10.1 Systems Biology and Networks 366 7.1.3 Transmitter Gated Signalling at the Synapse 294 8.2 Modeling of Metabolic Fluxes 366 8 Immune System 325 10.2 Conduction of the Action Potential along the Axon 294 7.6 Axonal Transport 296 7.3.1 Biosynthesis and Properties of Hemoglobin and Antibodies 330 Myoglobin 282 8.2 Autoimmunity 353 7.4.5 Muscle Contraction 305 9.2 Contact Activation 358 7.1.4 Receptors Coupled to Heterotrimeric G-Proteins 299 7.4.6 Programmed Cell Death (Apoptosis) 319 9.

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