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cortex

www.thalamus.ro
www.thalamus.ro
The Thalamus striatum
GABAergic striatal neurons
GABAergic striatal
neuroscience & medicine neurons containing
substance P
monosynaptic contacts
enkephalin
GPi
s, polysynaptic

l yst
,
ists olog
a eld
s p eci neur ers f i supress
deep brain s, s, ch he
d ent ntist esear d in t
stu cie , r te increase
stimulation for euros rgens teres SNr
n rosu ll in
mechanism neu d for
a
an GPe, STN
Deep Brain Stimulation excitatory glutamatergic
Neuronal & Network Mechanism projection

on www.thalamus.ro
inhibited by


Recordings from the cell body of
corpus pineale
computer model of neurons showed crus fornicis
suppression of activity during HFS, but
activity recorded in the cell body was truncus corpori callosi

not similar with the neural output


vent. lat.
generated in the axon even though
activity in the somas of neurons is
suppressed under HFS, the axons in a fissura long. cerebri nuc. habenulae medialis
pulvinar
rage of 2 mm have the output in concor- truncus corpori callosi
corpus geniculatum mediale
dance with the applied stimuli.
vent. lat. nuc. habenulae medialis
Cameron C. et al J Neurophysiol 2004.crus posterius caps. internae pulvinar
TRANSLATIONAL PHYSIOLOGY Cellular retrolenticularis corpus geniculatum mediale
corpus geniculatum laterale
Effects of Deep Brain Stimulation: Model- vent. lat. cornu temporale cauda nuc. caudati
Based Analysis of Activation and Inhibi- subst. grisea centralis
colliculus cranialis
tion hippocampus


pons
DBS determines on thalamic neurons a emin.colat.
homosynaptic depression restricted to fimbria hippocampi
the stimulated pathway, leaving the sulcus hippocampi
postsynaptic cell responsive to synaptic comisura habenularum
input from another, independent
pathway. Also, DBS reduces tremor
without disrupting normal motor
control. Homosynaptic depression is
essentially a presynaptic phenomenon, convergent pathways
and desensitization of postsynaptic
AMPA receptors does not play a signifi-
inh
ibi
cant role probably the cause for homo- ted
synaptic depression is transmitter deple- pro
pa
tion. ga
tio
Trent R. Anderson et al,The Journal of n
Neuroscience, 2006,Neurobiology of dbs electrode
Disease Selective Attenuation of Afferent
Synaptic Transmission as a Mechanism of Deep Brain Stimulation Research Review
Thalamic Deep Brain Stimulation-Induced 7 web pages and 17 A4 pdfs on DBS
Tremor Arrest
mechanism on www.thalamus.ro in
Thalamus in Neurology, Neurosurgery
and Pharmacology Site Section
More on:
www.thalamus.ro/surg/mechdbs.html
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