Professional Documents
Culture Documents
TABLE 1
American Cancer Society (ACS) Guidelines on Nutrition and Physical Activity for Cancer Prevention
ACS Recommendations for Individual Choices
Eat five or more servings of a variety of vegetables and fruits each day.
Choose whole grains in preference to processed (refined) grains and sugars.
Limit consumption of red meats, especially those high in fat and processed.
Choose foods that help maintain a healthful weight.
Adults: engage in at least moderate activity for 30 minutes or more on five or more days of the week; 45 minutes or more
of moderate-to-vigorous activity on five or more days per week may further enhance reductions in the risk of breast and
colon cancer.
Children and adolescents: engage in at least 60 minutes per day of moderate-to-vigorous physical activity at least five
days per week.
Public, private, and community organizations should work to create social and physical environments that support the adoption
and maintenance of healthful nutrition and physical activity behaviors.
measures to support healthy behaviors by that make it difficult to follow diet and activity
increasing access to healthful food choices and guidelines. Indeed, current trends toward
opportunities to be physically active. increasing consumption of high-calorie
convenience foods and restaurant meals, and
declining levels of physical activity are
AMERICAN CANCER SOCIETY GUIDELINES FOR contributing to an alarming epidemic of
NUTRITION AND PHYSICAL ACTIVITY obesity among Americans of all ages and across
all population segments.2 Longer workdays and
Recommendation for Community Action more households with multiple wage earners
reduce the amount of time available for
Social, economic, and cultural factors preparation of meals, with a resulting shift
strongly influence individual choices about toward increased consumption of food outside
diet and physical activity. While most the homeoften processed foods, fast foods,
Americans would like to adopt a healthful and snack foods. Reduced leisure time,
lifestyle, many encounter substantial barriers increased reliance on automobiles for
transportation, and increased availability of individual lifestyle choices and in public policy.
electronic entertainment and communications Public, private, and community organizations
media all contribute to a less active and should strive to create social and physical
increasingly sedentary lifestyle.These trends are environments that support the adoption and
of particular concern, especially with regard to maintenance of healthful dietary and physical
the adverse effects they have on the long-term activity behavior patterns.
health of children, who are establishing lifetime
patterns of diet and physical activity, as well as Recommendations for Individual Choices
on the poor, who live in communities with less
access to safe and healthful lifestyle options. There is strong scientific evidence that
Facilitating improved diet and increased healthful dietary patterns, in combination with
physical activity patterns will require multiple regular physical activity, can reduce cancer
strategies, ranging from the implementation of risk.4,5 Approximately 35 percent of cancer
community and work-site health promotion deaths in the United States may be avoidable
programs to policies that affect community through dietary modification.8,9,10,11 The
planning, transportation, school-based physical scientific study of nutrition and cancer is
education, and food services. Particular efforts highly complex, and many important questions
will be needed to ensure that all population remain unanswered. It is not presently
groups have access to healthful food choices clear how single nutrients, combinations of
and opportunities for physical activity. Both nutrients, overnutrition and energy imbalance,
public and private organizations at the local, or the amount and distribution of body fat
state, and national levels will have to develop at particular stages of life affect ones risk of
new policies and will need to raise or reallocate specific cancers. However, epidemiological
resources to facilitate needed changes. Health studies have shown that populations whose
care professionals, who can be especially diets are high in vegetables and fruits and low
persuasive on matters of lifestyle change, can in animal fat, meat, and/or calories have a
provide leadership in promoting policy reduced risk of some of the most common
changes in their communities. types of cancer. Until more is known about the
The decline in cigarette use by adults specific components of diet that influence
provides a useful analogy for the power of social cancer risk, the best advice is to emphasize
context in changing health behaviors. Adult- whole foods and certain broad dietary patterns,
per-capita cigarette consumption began a as described within these guidelines.
sustained decline after the 1964 Surgeon
Generals Report, which publicized the health 1. Eat a variety of healthful foods, with an
hazards of smoking.6 From that time on, other emphasis on plant sources.
community-wide social and political factors
have become increasingly important in reducing Eat five or more servings of a variety of
smoking. These include public policy changes vegetables and fruits each day.
regulating cigarette advertising, restricting Include vegetables and fruits at every
minors access to tobacco products, increasing meal and for snacks.
taxation of tobacco products, and addressing Eat a variety of vegetables and fruits.
concerns about rights of nonsmokers, and Limit French fries, snack chips, and other
exposure to second-hand smoke. Establishing fried vegetable products.
healthful patterns of diet and physical activity Choose 100% juice if you drink fruit or
will require similar purposeful changes in vegetable juices.
Choose whole grains in preference to lower risk of lung cancer among those who eat
processed (refined) grains and sugars. more vegetables and/or fruits in their
Choose whole grain rice, bread, pasta, diet.12,13,14,15 Although the major factor that
and cereals. causes lung cancer is tobacco smoking, diet also
Limit consumption of refined modifies risk, both in smokers and in lifelong
carbohydrates, including pastries, nonsmokers.
sweetened cereals, soft drinks, and sugars. Evidence that vegetable and fruit
consumption reduces cancer risk has led to
Limit consumption of red meats, especially attempts to isolate specific nutrients and to
those high in fat and processed. administer these in pharmacological doses to
Choose fish, poultry, or beans as an high-risk populations. Most of these attempts
alternative to beef, pork, and lamb. have been unsuccessful in preventing cancer or
When you eat meat, select lean cuts and its precursor lesions, and in some cases, have
have smaller portions. had adverse effects. Notable examples are the
Prepare meat by baking, broiling, or three randomized trials of beta-carotene for
poaching rather than by frying or the prevention of lung cancer, initiated because
charbroiling. of many observational epidemiological studies
indicating lower risk of lung cancer in persons
Choose foods that help you maintain a eating foods high in beta-carotene.Two of the
healthful weight. clinical trials showed that smokers taking high-
When you eat away from home, choose dose beta-carotene supplements developed
foods that are low in fat, calories, and lung cancer at higher rates than those taking a
sugar, and avoid large portion sizes. placebo,14,15 while a third study showed no
Eat smaller portions of high-calorie effect.16 These findings support the idea that
foods. Be aware that low-fat or beta-carotene may be only a proxy for other
nonfat does not mean low-calorie, single nutrients or combinations of nutrients
and that low-fat cakes, cookies, and found in whole foods, and that taking a single
similar foods are often high in calories. nutrient in large amounts may be harmful.
Substitute vegetables, fruits, and other It is presently unclear which components of
low-calorie foods for calorie-dense foods vegtetables and fruits are most protective
such as French fries, cheeseburgers, pizza, against cancer.17 Vegetables and fruits are
ice cream, doughnuts, and other sweets. complex foods, each containing more than 100
potentially beneficial vitamins, minerals, fiber,
Beneficial Effects of Vegetables and Fruits and other substances that may help to prevent
cancer. Vegetables and fruits also contain
Greater consumption of vegetables, fruits, or specific phytochemicals, such as carotenoids,
both together has been associated in the flavonoids, terpenes, sterols, indoles, and
majority of epidemiological studies with a phenols that show benefit against certain
lower risk of lung, oral, esophageal, stomach, cancers in experimental studies. There is
and colon cancer. Evidence is less strong for ongoing research, for example, on the potential
cancers considered hormonal, such as breast benefits of green and dark yellow vegetables,
and prostate. Diet can be an important factor plants related to the cabbage family, soy
even in cancers caused, in large part, by other products, legumes, allium (onion and garlic),
factors. For instance, many studies have found a and tomato products. Until more is known
TABLE 2
about specific food components, the best What Counts as a Serving?
advice is to eat five or more servings of a
Fruits
variety of vegetables and fruits in their various
1 medium apple, banana, or orange
forms: fresh, frozen, canned, dried, and juiced.
1/2 cup of chopped, cooked, or canned fruit
Despite recommendations from numerous 3/4 cup of 100% fruit juice
health agencies to eat at least five servings of
vegetables and fruits each day, intake of these Vegetables
foods remains low among adults and 1 cup of raw, leafy vegetables
children.18,19 Concern about low-intake levels 1/2 cup of other cooked or raw vegetables, chopped
has led to a nationwide initiativethe National 3/4 cup of 100% vegetable juice
5 A Day for Better Health programto help Grains
insure that vegetables and fruits are available 1 slice of bread
and accessible to all population groups, and to 1 ounce of ready-to-eat cereal
increase vegetable and fruit consumption to 1/2 cup of cooked cereal, rice, or pasta
five or more servings per day.20
Beans and nuts
1/2 cup of cooked dry beans
Whole Grains 2 tablespoons of peanut butter
1/3 cup nuts
Grains such as wheat, rice, oats, and barley,
and the foods made from them, constitute the Dairy foods and eggs
basis of a healthful diet. Whole grains are an 1 cup of milk or yogurt
important source of many vitamins and 11/2 ounces of natural cheese
2 ounces of processed cheese
minerals that have been associated with lower
1 egg
risk of colon cancer, such as folate, vitamin E,
and selenium.21 Whole grains are higher in Meats
fiber, certain vitamins, and minerals than 2-3 ounces of cooked, lean meat, poultry, or fish
processed (refined) flour products. Although
Source: US Department of Agriculture and US Department
the association between fiber and cancer risk is of Health and Human Services. Nutrition and Your Health:
Dietary Guidelines for Americans, 4th ed. Home and Garden
inconclusive,22,23 consumption of high-fiber Bull 232. Washington, DC: Government Printing Office,
foods is still recommended. Since the benefits 1995.
grain foods impart may derive from their other
nutrients as well as from fiber, it is best to
obtain fiber from whole grainsand
vegetables and fruitsrather than from fiber Dietary Fat and Consumption of Red Meat
supplements. As shown in Table 2, standard
portion sizes are quite small. High-fat diets have been associated with an
Beans are excellent sources of many increase in the risk of cancers of the colon and
vitamins and minerals, protein, and fiber. Beans rectum, prostate, and endometrium. The
are legumes, the technical term for the family association between high-fat diets and breast
of plants that includes dried beans, pinto beans, cancer is much weaker. Research continues to
lentils, and soybeans, among many others. examine whether the association between
Beans are especially rich in nutrients that may high-fat diets and various cancers in some
protect against cancer24 and can be a useful epidemiological studies is due to the total
low-fat, high-protein, alternative to meat. amount of fat, the particular type of fat
(saturated, monounsaturated, or polyun- lean meats and lower-fat dairy products, and
saturated), the calories contributed by fat, or substitute vegetable oils for butter or lard. Food
some other factor associated with high-fat labels can be a useful guide to choosing
foods. Fats such as the saturated fat in red packaged foods lower in saturated fat. Choose
meats, omega-3 fatty acids in fish oils, or smaller portions and use meat as a side dish
monounsaturated fats in olive oil, for example, rather than as the focus of a meal. Emphasize
likely differ in their effects on cancer risk.The beans, grains, and vegetables in meals to help
relationship between specific types of fat and shift dietary patterns to include more foods
certain cancers is an important area of current from plant rather than animal sources.
research.25 Preparation methods are also important.
Because a gram of fat contains more than Baking and broiling meat, rather than frying,
twice the calories of a gram of protein or reduces its overall fat content. Meat should be
carbohydrates (9 versus 4 kcal/gram), studies cooked thoroughly to destroy harmful bacteria
cannot easily distinguish the effects of fat itself and parasites, but should not be charred.
from the effects of the calories it contains. In
addition, dietary fat consumption is also Choosing Foods that Help Maintain a
correlated with greater consumption of meat Healthful Body Weight
and calories; lower consumption of vegetables,
fruits, and grains; and higher body weight, so Most people cannot maintain a healthful
that it may be difficult to disentangle the body weight without limiting caloric intake
separate contribution of fats to cancer risk. while maintaining regular physical activity.
Foods from animal sources remain major Current trends indicate that the largest
contributors of total fat, saturated fat, and percentage of calories in the American diet
cholesterol in the American diet.26 Although comes from foods high in fat, sugar, and refined
meats are good sources of high-quality protein carbohydrates. Consuming a varied diet that
and can supply many important vitamins and emphasizes plant-based foods may help to
minerals, consumption of meatespecially red displace these calorie-dense foods. Limiting
meats (beef, pork, lamb)has been associated portion sizes, especially of these types of foods,
with cancers in many studies, most notably is another important strategy to reduce total
those of the colon and prostate.27 How much caloric intake.
of this association is due to specific constituents Replacing dietary fat with foods that are
within meat (such as saturated fats) or to high in calories from sugar and other refined
correlated dietary factors is presently carbohydrates does not protect against obesity.
unclear.28,29,30 For example, mutagenic The decrease in fat intake and increase in
compounds, such as heterocyclic amines, are consumption of refined carbohydrates that
produced when protein is cooked at a high occurred in the United States between 1977
temperature, and may contribute to the and 1995 coincided with an 8% increase in the
association between meat and colon cancer. prevalence of obesity.31,32 Excessive intake of
Much evidence indicates that saturated fat sugar and other highly-refined carbohydrates
may be particularly important in increasing may contribute to insulin insensitivity,
risk of cancer as well as for heart disease. The alterations in the amount and distribution of
best way to reduce saturated fat intake is to body fat, and increased concentrations of
make wise choices in the selection and growth factors that may promote the growth of
preparation of animal-based foods. Choose cancers.
TABLE 3
Examples of Moderate and Vigorous Intensity Physical Activities
2. Adopt a physically active lifestyle.
Moderate Intensity Activities Vigorous Intensity Activities
Adults: engage in at least moderate
activity for 30 minutes or more on five Exercise Walking, dancing, leisurely bicycling, Jogging or running, fast bicycling,
and Leisure ice skating, roller skating, horseback circuit weight training, aerobic
or more days of the week; 45 minutes or riding, canoeing, yoga dance, martial arts, jumping rope,
more of moderate-to-vigorous activity swimming
on five or more days per week may Sports Volleyball, golfing, softball, baseball, Soccer, field or ice hockey,
further enhance reductions in the risk badminton, doubles tennis, lacrosse, singles tennis,
downhill skiing racquetball, basketball,
of breast and colon cancer. cross-country skiing
Children and adolescents: engage in at
least 60 minutes per day of moderate-to- Home Mowing the lawn, general lawn Digging, carrying and hauling,
Activities and garden maintenance masonry, carpentry
vigorous physical activity for at least five
days per week. Occupational Walking and lifting as part of the job Heavy manual labor (forestry,
Activities (custodial work, farming, auto or construction work, fire fighting)
machine repair)
Benefits of Physical Activity
TABLE 4
Suggested Ways to Reduce Sedentary Behavior
physical activity is most protective if done in a
Use stairs rather than an elevator. single session or incrementally throughout the
If you can, walk or bike to your destination. day, it is reasonable to assume that benefit can
be accumulated in separate sessions of 20 to 30
Exercise at lunch with your co-workers, family, or friends. minutes each.
Take a 10-minute exercise break at work to stretch or Adopting a physically active lifestyle
take a quick walk. involves making deliberate decisions and
Walk to visit co-workers instead of sending an e-mail changing lifestyle behaviors in order to select
message. active rather than sedentary behavior. To
Go dancing with your spouse or friends.
enhance the ability of individuals to adopt a
more active lifestyle, communities as well as
Plan active vacations rather than only driving trips. individuals need to implement changes. Ideas
Wear a pedometer every day and watch your daily steps to reduce sedentary behavior are suggested in
increase. Table 4.
Join a sports team. People who are less active than
recommended by these guidelines should
Use a stationary bicycle while watching TV. gradually increase the intensity, duration, and
Plan your exercise routine to gradually increase the days frequency of physical activity. Most children
per week and minutes per session. and young adults can safely engage in
moderate physical activity without consulting
their physicians. However, men over 40,
extensive review by the World Health women over 50, and people with chronic
Organization.47 illnesses and/or established cardiovascular risk
For people who are largely inactive or just factors should consult their physicians before
beginning a physical activity program, a beginning a vigorous physical activity
gradual increase to 30 minutes per day of program. Stretching and warm-up periods
moderate-to-vigorous physical activity on at should be part of each exercise session to
least five days per week will provide substantial reduce risk of musculoskeletal injuries. More
cardiovascular benefits and aid in weight detailed information on exercise safety can be
control.48,49 Those who are already active at least found in the Surgeon Generals Report on
30 minutes on most days of the week should Physical Activity and Health.52
strive toward accumulating 45 minutes of Because one of the best predictors of adult
moderate-to-vigorous activity on most days of physical activity is activity levels during
the week. Selected examples of moderate and childhood and adolescence, and because of the
vigorous activities are provided in Table 3. critical role physical activity plays in weight
Moderate activities are those that require maintenance, children and adolescents should
effort equivalent to a brisk walk. Vigorous be encouraged to be physically active at
activities generally engage large muscle groups moderate-to-vigorous intensities for at least 60
and cause an increase in heart rate, breathing minutes per day on five or more days per
depth and frequency, and sweating. These week.53,53a Such activities should include sports
activities can be performed in a variety of and fitness activities at school and at home. To
settings: occupational, recreational, in the home help achieve activity goals, daily physical
or garden, and with friends or family.50,51 While education programs and activity breaks should
there is limited evidence regarding whether be provided for children at school, and
television viewing and computer game time strive to maintain a BMI between 18.5 and
should be minimized at home. 25.0 kg/m2.
The health benefits of physical activity in The best way to achieve a healthful body
preventing cancer and other chronic diseases weight is to balance energy intake (food
are thought to accumulate over the course of a intake) with energy expenditure (physical
lifetime5 and are facilitated by the development activity). Excess body fat can be reduced by
of healthy activity patterns in childhood. restricting caloric intake and increasing
However, increasing the level of physical physical activity. Caloric intake can be reduced
activity at any age can provide important by decreasing the size of food portions and
health benefits. Although it is uncertain at the limiting the intake of calorie-dense foods high
present time whether increasing physical in fat and refined sugars (e.g., fried foods,
activity among the elderly will reduce cancer cookies, cakes, candy, ice cream, and soft
risk, many other health benefits can be drinks). Such foods should be replaced with
achieved by an appropriate exercise regimen, foods like vegetables and fruits, whole grains,
even among the elderly.54 and beans. People should be aware that meals
served in restaurants typically exceed the
3. Maintain a healthful weight throughout life. portion sizes needed to meet recommended
Balance caloric intake with physical daily caloric intake. Physical activity as well as
activity. diet is essential for maintenance of a healthful
Lose weight if currently overweight weight (see Recommendations for Individual
or obese. Choices, recommendation number two,
page 99).
Balancing Energy Intake and Expenditure As yet, no studies have convincingly
demonstrated that losing weight reduces the
Overweight and obesity are associated risk of cancer, although there are biologically
with increased risk for cancers at several sites: plausible mechanisms to suggest that weight
breast (among postmenopausal women), loss might be beneficial. Overweight or obese
colon, endometrium, adenocarcinoma of the individuals who intentionally lose weight have
esophagus, gallbladder, pancreas, and kidney. reduced levels of circulating glucose, insulin,
These findings are supported both by and bioavailable estrogens and androgens. The
animal studies and by epidemiological health effects of intentional weight loss are
studies.30,40,41,55,56,57,58,59,60 difficult to evaluate, because people who
The Body Mass Index (BMI) is an manage to lose weight may do so because of
expression of weight-for-height calculated as unrecognized illness. Weight loss that results
body weight in kilograms divided by height in from an underlying illness or from smoking
meters, squared.61 Exact cut-offs for BMI levels does not benefit ones health. Even though our
at elevated risk are difficult to define, since knowledge about the relationship between
epidemiological studies have used different weight loss and cancer risk is incomplete,
cutpoints in calculating cancer risks associated individuals who are overweight and obese
with body weight. However, experts consider should be encouraged and supported in their
a BMI within the range of 18.5 to 25.0 kg/m2 efforts to reduce weight. Obesity is a major risk
to be healthful, a BMI between 25.0 and 29.9 factor not only for cancer, but also for diabetes,
to be overweight, and a BMI of 30.0 and over stroke, and coronary heart disease.
to be obese (Figure 1). Individuals should Because overweight in youth tends to
FIGURE 1
Are You at a Healthy Body Weight?
BMI (Body Mass Index)
Height*
.5
18
30
25
6'6"
6'5"
6'4"
6'3"
6'2"
6'1"
6'0"
5'11"
5'10"
5'9"
5'8"
5'7"
5'6"
5'5"
5'4"
5'3"
5'2"
5'1"
5'0"
4'11"
4'10"
50 75 100 125 150 175 200 225 250 275
Pounds *Without shoes. Without clothes.
BMI measures weight in relation to height. The BMI ranges shown above are for adults. They are not exact ranges of
healthy and unhealthy weights. However, they show that health risk increases at higher levels of overweight and obesity.
Even within the healthy BMI range, weight gains can carry health risks for adults.
Directions: Find your weight on the bottom of the graph. Go straight up from that point until you come to the line that
matches your height. Then look to find your weight group.
Source: Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2000, page 3.
The higher weights apply mainly to men who have more muscle and bone. To use this chart, find your height in feet and
inches (without shoes) along the left side of the graph. Trace the line corresponding to your height across the figure until it
intersects with the vertical line corresponding to your weight in pounds (without clothes). The point of intersection lies within a
band that indicates whether your weight is healthy or is moderately or severely overweight.
continue throughout life, the increasing alcohol, but this relationship has not been
prevalence of overweight and obesity in pre- firmly established.4
adolescents and adolescents may increase the Complicating the recommendation for
incidence of cancer in the future. For these alcohol and cancer risk reduction is the
reasons, efforts to establish healthful weight, evidence that even moderate intake of
physical activity habits, and patterns of weight alcoholic beverages appears to decrease the risk
gain should begin in childhood. of coronary heart disease in both men and
women.65,66 Even though alcohol can reduce
4. If you drink alcoholic beverages, limit the risk of coronary heart disease in women,
consumption. those women who are at high risk of breast
cancer might reasonably consider abstaining
People who drink alcohol should limit their from alcohol. Public health officials advise
intake to no more than two drinks per day for people who already drink alcoholic beverages
men and one drink a day for women.2 The to limit their intake to two drinks a day for
recommended limit is lower for women men and one drink per day for women.There
because of their smaller body size and slower is no compelling reason for adults who
metabolism of alcohol. A drink of alcohol is currently do not consume alcoholic beverages
defined as 12 ounces of beer, five ounces of to start consuming alcohol to reduce their risk
wine, or 1.5 ounces of 80-proof distilled spirits. for heart disease, as cardiovascular risk can be
Alcohol consumption is an established cause of reduced by not smoking, consuming a low-
cancers of the mouth, pharynx, larynx, saturated fat diet, avoiding obesity, staying
esophagus, liver, and breast.62,63 Alcohol physically active on a regular basis, and
consumption may also be related to increased controlling blood pressure.
risk of colon cancer. For each of these cancers, Some groups of people should not drink
risk increases substantially with intake of more alcoholic beverages at all. These include
than two drinks per day. Alcohol consumption children and adolescents; individuals of any
combined with tobacco increases the risk of age who cannot restrict their drinking to
cancers of the mouth, larynx, and esophagus far moderate levels; women who are or may
more than the independent effect of either become pregnant; individuals who plan to
drinking or smoking. Furthermore, regular drive or operate machinery or who take part
consumption of even a few drinks per week in other activities that require attention, skill,
has been associated with an increased risk of or coordination; and individuals taking
breast cancer in women. The mechanism by prescriptions or over-the-counter medications
which alcohol is related to breast cancer is not that can interact with alcohol.
known with certainty, but may be due to
alcohol-induced increases in circulating
estrogens or other hormones in the blood, DIET AND PHYSICAL ACTIVITY FACTORS
reduction of folic acid levels, or to a direct THAT AFFECT RISKS FOR THE MOST
effect of alcohol or its metabolites on breast COMMON CANCERS
tissue.64 Reducing alcohol consumption may
be an important way for many women to While the diet and activity factors presented
reduce their risk of breast cancer. Some studies within the guidelines are intended to reduce
suggest that consuming the recommended overall cancer risk, certain dietary and physical
amount of the vitamin folic acid can minimize activity habits affect specific cancer sites. This
the increased risk of breast cancer from section summarizes the relation of diet and
amounts of vegetables and fruits probably cancer.29,71 There is also evidence that a high
reduces the risk of oral and esophageal calcium intake, primarily through supplements,
cancers.At the present time, the best advice to is associated with increased risk for more
reduce the risk of oral and esophageal cancers aggressive types of prostate cancer.72 Other
is to avoid all forms of tobacco, restrict studies suggest that diets high in certain
alcohol consumption, avoid obesity, and eat vegetables (including tomatoes, beans, and
at least five servings of vegetables and fruits other legumes) are associated with decreased
each day.68,69,70 risk. Current evidence for these associations is
limited, however. The possibility that specific
Ovarian Cancer nutrients in foods, notably vitamin E, selenium,
and lycopene, may protect against prostate
There are no firmly established nutritional cancer is under active investigation. At the
risk factors for ovarian cancer, though vegetable present time, the best advice to reduce the risk
and fruit consumption may lower risk. of prostate cancer is to limit intake of animal-
based products, especially red meats and high-
Pancreatic Cancer fat dairy products; and eat five or more servings
of vegetables and fruits each day.
Pancreatic cancer is the fifth leading cause of
cancer death in the United States, accounting Stomach Cancer
for nearly 30,000 deaths annually. Substantial
evidence indicates that tobacco smoking, The incidence of stomach cancer continues
adult-onset diabetes, and impaired glucose to decrease worldwide, especially in the United
tolerance increase the risk for pancreatic States.Year-round consumption of fresh foods
cancer.39 Some studies have also shown that made possible by refrigeration, and other
obesity and physical inactivity (both factors improvements in food preservation methods
strongly linked to abnormal glucose have likely helped to reduce the rate of
metabolism) are associated with elevated stomach cancer, as has concomitant reduction
pancreatic cancer risk, and that fruit and in the prevalence of chronic stomach infections
vegetable intake is associated with reduced by the bacterium Helicobacter pylori. At the
risk.59 At the present time, the best advice to present time, the best advice to reduce the risk
reduce the risk of pancreatic cancer is to avoid of stomach cancer is to eat at least five servings
tobacco use, maintain a healthful weight, of vegetables and fruits daily.73
remain physically active, and eat five or more
servings of vegetables and fruits each day.
COMMON QUESTIONS ABOUT DIET AND CANCER
Prostate Cancer
Because people are interested in the
Prostate cancer is the most common cancer relationship specific foods or nutrients have to
among American men.While prostate cancer is specific cancers, research on dietary factors and
clearly related to male sex hormones, just how cancer risk is often widely publicized. Health
nutritional factors might increase risk remains professionals who counsel patients should
uncertain. Several studies have found high emphasize that no one study provides the last
consumption of red meat and dairy products to word on any subject, and that individual news
be associated with increased risk of prostate reports may overemphasize what appear to be
contradictory or conflicting results. In brief many other phytochemicals. Studies suggest that
news stories, reporters cannot always put new people who eat more vegetables and fruits,
research findings in their proper context. The which are rich sources of antioxidants, have a
best advice about diet and physical activity is lower risk for some types of cancer. Clinical
that it is rarely, if ever, advisable to change diet studies of antioxidant supplements are currently
or activity levels based on a single study or underway, but studies have not yet demonstrated
news report, especially if the data are reported a reduction in cancer risk from vitamin
as preliminary findings. The following supplements (see also Beta-carotene below;
questions and answers address common Lycopene, page 110; Selenium, page 111; Vitamin
concerns about diet and physical activity in E, page 114; Supplements, page 112). To reduce
relation to cancer. cancer risk, the best advice presently is to
consume antioxidants through food sources
Alcohol rather than supplements.
beta-carotene supplements may be harmful, should consult with their health care provider.
especially for cigarette smokers.14,15,16
Cholesterol
Bioengineered Foods
Does cholesterol in the diet increase cancer risk?
What are bioengineered foods, and are they safe? Cholesterol in the diet comes only from foods
Bioengineered foods are made by adding genes derived from animal sourcesmeat, dairy
from other plants or organisms to increase a foods, eggs, and animal fats. At present, there is
plants resistance to insect pests, retard spoilage, little evidence that cholesterol itself causes the
or improve transportability, flavor, nutrient increased risk of certain cancers associated with
composition, or other desired qualities. In eating foods from animal sources. Lowering
theory, these added genes might create blood cholesterol lowers cardiovascular disease
substances that could cause adverse reactions risk, but there is no evidence that lowering
among sensitized or allergic individuals. blood cholesterol has an effect on cancer risk.
However, there is currently no evidence that
the substances found in bioengineered foods Coffee
now on the market are harmful or that they
would either increase or decrease cancer risk Does drinking coffee cause cancer? Caffeine may
because of the added genes. heighten symptoms of fibrocystic breast lumps
(a type of benign breast disease) in some
Calcium women, but there is no evidence that it
increases the risk of breast cancer or other
Is calcium related to cancer? Several studies types of cancer.The association between coffee
have suggested that foods high in calcium and pancreatic cancer, widely publicized in the
might help reduce the risk for colorectal past, has not been confirmed by other studies.
cancer,74 and calcium supplementation
modestly reduces the formation of colorectal Fat
adenomas.There is also evidence, however, that
a high calcium intake, primarily through Will eating less fat lower cancer risk? Diets high
supplements, is associated with increased risk in fat are also high in calories and contribute to
for prostate cancer, especially for prostate obesity, which in turn is associated with
cancers that are more aggressive.72 In light of increased risk of cancers at several sites.
this, both men and women should strive to Although all types of fats have similar numbers
consume recommended levels of calcium of calories, there is some evidence that certain
intake, primarily through food sources. types, such as saturated fats, may have a greater
Recommended intake levels of calcium are effect on increasing cancer risk, and that fats
1000 mg/day for people aged 19 to 50 and containing omega-3 fatty acids may reduce
1200 mg/day for people over 50 years old. cancer risk (see Recommendations for Individual
Dairy products are excellent sources of Choices, recommendation number one, page 95).
calcium, as are some leafy vegetables and
greens. People who obtain much of their Fiber
calcium from dairy products should select low
or nonfat choices to reduce intake of saturated What is dietary fiber and can it prevent cancer?
fat.Those wishing to take calcium supplements Dietary fiber includes a wide variety of plant
carbohydrates that are not digestible by Current evidence suggests that to reduce
humans. Specific categories of fiber are cancer risk, folic acid is best obtained through
soluble (like oat bran) or insoluble (like consumption of vegetables, fruits, and
wheat bran and cellulose). Soluble fiber helps enriched grain products.
to reduce blood cholesterol and therefore,
helps lower the risk of coronary heart disease. Food Additives
Good sources of fiber are beans, vegetables,
whole grains, and fruits. Associations between Do food additives cause cancer? Many
fiber and cancer risk are inconclusive, but substances are added to foods to preserve them
consumption of these foods is still and to enhance color, flavor, and texture.
recommended because they contain other Additives are usually present in very small
substances that can help prevent cancer and quantities in food, and no convincing evidence
because of their other health benefits. exists that any additive consumed at these levels
causes human cancers.
Fish Oils
Garlic
Does eating fish protect against cancer? Fish is a
rich source of omega-3 fatty acids. Studies in Can garlic prevent cancer? The health benefits
animals have found that these fatty acids of the allium compounds contained in garlic
suppress cancer formation, and there is limited and other vegetables in the onion family have
suggestive evidence of a possible benefit in been publicized widely, mostly because garlic
humans. Research has not yet demonstrated has very small effects on blood cholesterol
whether the possible benefits of fish levels. Garlic is currently under study for its
consumption may be reproducible by taking ability to reduce cancer risk. Insufficient
omega-3 or fish oil supplements. evidence exists at this point to support a
specific role for this vegetable in cancer
Fluorides prevention.
Phytochemicals Selenium
What are phytochemicals, and do they reduce What is selenium and can it reduce cancer risk?
cancer risk? The term phytochemicals refers Selenium is a mineral needed by the body as
steaming may be the best ways to preserve the foods.Vitamin A is needed to maintain healthy
nutritional content in vegetables. tissues.Vitamin A supplements, whether in the
form of beta-carotene or retinol, have not been
Should I be juicing my vegetables and fruits? shown to lower cancer risk, and high-dose
Juicing can add variety to the diet, and can be a supplements may, in fact, increase the risk for
good way to consume vegetables and fruits, lung cancer.14,15
especially for those who have difficulty chewing
or swallowing. Juicing also improves the bodys Vitamin C
absorption of some of the nutrients in vegetables
and fruits. However, juices may be less filling Does vitamin C lower cancer risk? Vitamin C is
than whole vegetables and fruits and contain less found in many vegetables and fruits. Many
fiber. Fruit juice, in particular, can contribute lots studies have linked consumption of vitamin C-
of calories to ones diet. Commercially juiced rich foods with a reduced risk for cancer. The
products should be 100% vegetable or fruit juices few studies in which vitamin C has been given
and should be pasteurized to eliminate harmful as a supplement, however, have not shown a
microorganisms. reduced risk for cancer.85,86
Do vegetarian diets reduce cancer risk? Does vitamin E lower cancer risk? One clinical
Vegetarian diets include many health- trial showed that men who took vitamin E (50
promoting features; they tend to be low in mg/day) had a lower risk of prostate cancer
saturated fat and high in fiber, vitamins, and compared with men who took a placebo,14 but
phytochemicals (e.g., flavonoids, etc.). It is not this observation has yet to be confirmed.
possible to conclude at this time, however, that
a vegetarian diet has any special benefits for the Water and Other Fluids
prevention of cancer.Vegetarian diets differ in
composition, although all avoid consumption How much water and other fluids should I drink?
of red meat. A vegetarian diet can be quite Consumption of water and other liquids may
healthful if it is carefully planned and provides reduce the risk of bladder cancer, as water
adequate calories. Diets including lean meats in dilutes the concentration of carcinogens and
small to moderate amounts can be just as shortens the time in which they are in contact
healthful. The greater the restriction of food with the bladder lining. Drinking at least eight
groups in a particular diet, the more possibility cups of liquid a day is usually recommended,
there is of dietary deficiencies. Strict vegetarian and some studies indicate that even more may
diets that avoid all animal products, including be beneficial.65
milk and eggs, should be supplemented with
vitamin B12, zinc, and iron (especially for
children and premenopausal women). AMERICAN CANCER SOCIETY GRADES FOR
BENEFIT VERSUS HARM
Vitamin A
To review the strength of the scientific
Does vitamin A lower cancer risk? Vitamin A evidence, a guidelines subcommittee used a
(retinol) is obtained from foods in two ways: method of summarizing the evidence similar to
preformed from animal food sources, and the methods used by other expert panels. For
derived from beta-carotene in plant-based example, the US Preventive Services Task Force
judged the scientific evidence related to clinical of the scientific evidence for nutritional factors
preventive services using a system that in cancer prevention as being either
considered both the source and strength of the convincing, probable, possible, or insufficient.
evidence: from at least one controlled clinical The American Cancer Society sub-
trial, from good uncontrolled trials, from committee employed a method similar to both
multiple good observation studies, expert groups. For each issue, the committee judged
opinion, and case reports. They then the likelihood of benefit to the general public
characterized those guidelines on a five-point as follows:
grading scheme as to the strength of the A1. Convincing evidence for a benefit.
guideline: good for recommending, fair for A2. Probable benefit.
recommending, insufficient to recommend for A3. Possible benefit.
or against, fair for not recommending, good for B. Insufficient evidence to conclude
not recommending. The American Institute benefit or risk.
for Cancer Research (AICR) World Cancer C. Evidence of lack of benefit.
Research Fund project summarized the nature D. Evidence of harm.
TABLE 5
American Cancer Society Grades for Benefit Versus Harm (2001)*
Nutritional Factor Colorectal Breast Prostate Lung Esophageal, Stomach Pancreatic Bladder Endometrial
Cancer Cancer Cancer Cancer Oral Cancer Cancer Cancer Cancer Cancer
Increasing vegetable A2 A3 A3 A2 A2 A2 A3 A3 A3
and fruit intake
Limiting intake of A2 B A3 B B C A3 C B
red meat
Increasing physical A1 A1 B B B B B B A2
activity
Avoiding overweight A1 A1 C B A2 C A3 C A1
Taking beta-carotene B B C D B B B B B
supplements
Taking vitamin E B B A3 C B B B B B
supplements
Taking vitamin C B B B B B B B B B
supplements
Taking selenium A3 B A3 A3 B B B B B
supplements
*Note: Group met in 2001 and recommendations were adopted by the American Cancer Society Board of Directors in November, 2001.
THE AMERICAN CANCER SOCIETYS COMMIT- nutrition, physical activity, and cancer; and to
MENT TO NUTRITION AND PHYSICAL ACTIVITY develop education programs and interventions
FOR CANCER PREVENTION designed to improve the dietary and activity
habits of people of all ages.
The American Cancer Society is committed The ACS also recognizes that many
to improving the ability of Americans to eat a important questions about nutrition, physical
healthful diet and to be active because of the activity, and cancer risk remain unanswered.
potential impact of diet and activity on cancer The ACS will continue to support an ongoing
risk.The ACS has set aggressive challenge goals program of research that addresses biological,
for the nation to decrease cancer incidence and clinical, epidemiological, behavioral, and policy
mortalityand to improve the quality of life of studies on the role diet and physical activity
cancer survivorsby the year 2015. As part of play in cancer prevention. Greater efforts on
its strategic plan for achieving these goals, the the part of individuals in public and private
ACS has established nationwide nutrition and agencies are also needed to translate these
physical activity objectives: to increase the guidelines into effective action that reduces the
awareness of the relationship of nutrition and burden of cancer among Americans.
physical activity to cancer risk and to motivate The ACS continues to support nutrition
and enable all Americans to lead a healthful and research in two ways: by conducting its own
active lifestyle. research, and by funding outstanding research
To address these critical goals, the ACS projects throughout the country. Staff scientists
publishes its Nutrition and Physical Activity of the ACS are conducting epidemiological
Guidelines to serve as a foundation for its research in which they analyze and interpret
communication, policy, and community data related to cancer mortality with regard
strategies and ultimately, to affect dietary and to lifestyle among a population of more than
physical activity patterns among Americans. one million people. In addition, scientists
These guidelines, published every five years, are throughout the United States apply for
developed by a national panel of experts in research grants for their own investigations.
cancer research, prevention, epidemiology, The ACS reviews these applications rigorously,
public health, and policy, and they represent the and awards funding to only the most
most current scientific evidence related to meritorious proposals. Studies supported by
dietary and activity patterns and cancer risk. the ACS on the role of diet and activity on
Recognizing that the ability to make healthful cancer risk have been made possible by the
choices is often affected by factors within the efforts of nearly 100,000 volunteers and
environment in which people live, work, and the financial contributions of millions of
play, the guidelines also attempt to identify key Americans.
social and structural factors that influence To reverse current trends in diet and activity
access to resources for a healthful, active habits and the resultant increases in overweight
lifestyle.The ACS makes use of these guidelines and obesity among many segments of the
to influence legislative and regulatory issues populationincluding both youth and
that support nutrition and physical activity; to adultsincreased attention and dedicated
influence environmental changes that increase resources are needed. Positive action on the
public access to and availability of healthful part of communities, public and private
foods and opportunities for physical activity; to organizations, and individuals working together
advise the public about issues related to to raise the awareness of this issue and to
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