You are on page 1of 70

c

c
 c

c c c
c c
 c c c c c
 !"#c c   c $ % "#c
& c
c 'c(  c  c
)*cc%c c+c

&"c,   c

c

-$c c($ c .. 

/c
c

c
c
c
 c

c
c

c  c

c c

c
 c

c c c
 c
c c c c c
 !"#c c   c $ % "#c
&
c c
c 'c(  c  c
)*cc%c c+c
c
&"c,   c

c
c

c
O 
.0c1cccccccccccccccccccccccccccccccccccccccccccccccccccccccc
1.c(c
.+c
'c
%2 2 cc
Ô c



  
c
Ô 

 !

c
p 
c  c  c c  
c


c c
  c
cccc  c cc  
c
c c
cc c
 c
c
c
c
 c  c 
c

c c 

c 


c   c

c  c  
 c c 
c 
c c c 
c
 c  c


c 
c c  c 
c  c  c 
c c 
c  c c 
c  c
 cc

cc
cc

c cc 

cc
c c c c
c

c
c
 c

c  c 
c  c 

c  c c c 

c  
c c  c 
c 
  
c 
c c c
c  c c



c
 cc c c

c c

c c
c
c 
c cc

cc
c 

c
c


c cc
c c
c 
c
c  cc
cc
c c
c 
c c  

c c c c 
c c 
c c  c  c c 

c 
c 



c 
c
   c  
c 

c  c 


c 
c c 
c c 


c 
c  c 


c c 

c
 
 
c !c

c !c
c



c c c c c  cc
c c
c c
c
cc c 
 c cc
c c
c

c c 
 cc
c

c


c c c 

c
c
  c  c c
 c
c  c c c 
 c
  c  c
c
 
"c
 !c c
cc

 c
c c c
 
cc
 c
c

c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c

c
c
c

c
c
c

!  
cc
c

c
# 
c
cc c  c cc

c c

c
c$ c
c

c
cc
 
c
c

 c 
 c 
c 
c  c c  c  c c  

c c 
c  c  c  c 
c c
c
"   c cc  c c 
cc

c 
 cc 
c c cc  
c
 cc c c
c
c



c c

c

c   c
 cc
c

 c
 c 
c 


c  c  c 
c  

c c c

 !c

c c 
c % c 

c   c c

" 
cc c
 !c


c 
c
!c c

c
 cc
c&

!c
c


c c cc
" 
ccc

c c
"
c

!cc
c c c
 c
 c
c
c
c c !c
c

 c c

c c
 
c
 cc
c


c
 cc
c
c c

!c

c
cc

c
c'(()c c 
c  *ccc

c
c c
c


c 
ccc c c
 c
cc
ccc
#
c
 c

c c c  
cc
c
 c c c

 c


c c
c  c   
c c 
 
c 
c c  c 
!c c c c c c 
 c c
  c  c
cc  c 
c +
c c  c 

c cc
  cc 
c c c c%
c c
c 

c 
 
c c c  c 
c

c  c 
c  c c 
c ,
c c c c 
c 
c
 c
 c
c
c
 
c
c

 c cc c c
 
cc 
c
 c
c 
c c  c c

c


c 
 
c cc c
c
c#c c

c 
c c c
c c
 c
c
 
c
cccc

cc c

c  c
c c  
c "c 
c  c  
c  c c 

c c    c c c &

!c  c
  
c  c c c 
c  c  c 
 !c  c c c c   c 

c c

c

c
"c

c c
c c 
c
c
c 
cc
 c#cc

c
c
c
cc c

c


cc   cc

c 
c c ccc

cc
c
c  c
c  c c


c  c 
c
c   c  cc
c c c 
c c
c c
cc

c c !c
c



c c
c cc
c
cc
c c
c+
cc cc 
 c


c

c c


c
 c

c
c
c


c c

c 
 c c  c 
c c 
c 


c 
c 
c c

c  c


c 
c c 

c  c 
c
 
c c

c 
c  
c  c 
c  c c c

c 
c 
c  c
" 
c c c  c 


c c -$.c 
c c  
c c 
c  c
 c c cc  cc
  c c
c c  c  c 
c


c  cc  
 c

c 
c  c 


c 
c c 
c c c c 


c c 
c  
c c   c

 
c c

 
c  c !c c c c c  c c c  
c 
c 
 
c 
c c 
c
 c



c
cc
cc
c c  
 c 


c 


c  c c
c
c  c
c  c 
 c 
c
cc
 c
 cc   c 
c
c
cc

c
%

c 
cc c
c
 ccc


c 
c

c  c 
c    c  
c  c c c 
c c  
c  c 
 c

 c  c 

c 
 c c 
c c 

c 
c c  c 
 c 
 c 
c 
c 


c
cc


c 

c   c  c 
 cc c &&/c
c

c  cc c
cc
"  cc


c c


c
cc

c 
c
c"cc
c   c c 
 c 

c c    c  
c c c c  c
c  c

c 
c c c
c c  cc


c

c cc

c  c  cc
c

c-

c c
c

c cc c
c
c
ccc c   c 
cc
c 

cc
c c


c c 
c 
c    c 
c c 
c

c  c 
c  c c 
 c

c
 c
 
c!cc 



c

c c
cc cc
c c
c
c
 c 
c  c 
!c c 

c 

c 
c 

c 
c   !c c 
  c

c  c 
c  c

c c

!cc
c
c


c
cc

cc
c c

c"c
  c c
'0(c
c
cc
 c c 
c 
c  c c 
c 
c 
c 
c  c 
 !c c 
 c 123c  c   45c
  c 1#3c c  

c c 
c   c  c 
c   c c  c 


c    c 

c
!c  c c c   c

 c c


c
cc c   c 
cc
#!cc   c 
c c 
 c


c c c

c

cc cc
c
cc
c
c
 c c 
c c 
c %
 c c 
c c c 
c


c c 
c 
c  c 
c  
c c
c c 
6c -c 

c  c 
c c c 
c 
  
c c c  6c c c
 c
 c c
c


cc c 6c c
cc 
c

ccc

cc
cc
cc
'ccccc7c 
cc c c
c
 cc
6c
cc
 c
c c  c


cc

ccc

c c

c c
c cc
!cc cc
c
c

cc
c
c ccc ccc 
c c
c c

c c

c

cc
c 
c
 c 


c  c 
c  c  c  c 


c 
c c c c 
c 
c

c  c c  c

c  c 
c  c c 
c 
c 


c 7
c  c 
c  c 
c 
 c 
c
c 
c 
c  c
 
c cc

c c   c  
c

c
c  c c   c 
cc

c
cc

c


c

ccc   ccc
cc

c
c


cc c
 c
"
c "c
  c c c 
c  
c  c   c  c 
c   c
 c
c c
c   c

c cc c
ccc
cc
cc
0c c c c c  c 
c 



c  c 
c 
c c 
c c  c  c 

c  !c c 
c  c  c
 c
c
 6c
cc
 c
c 



c
cc c  c

 
c  
c c 


c
c c c  c

c cc c
cc c
cc c c

c
 c c
c
c
 c
cc
ccccc7c
c c

c
 c
cc
c c
c 6c
cc
 cc 
cccccc

c

c cc
c c
c
 ccc
c c c
c 

c c 
c c  c  c c  c    c 
c 5c c  
c c 
c

c 
c


c  c 
c 

c 
c 
 c c 

c  
c  c 
c 
%

c
 
cc
 c 

c
c  c c  c c  c   c  
cc 
 c c
"  c
 cc
cc 
 c

c c c
c
8cc 
c  c2c cc 
c
ccc 
6cc
c
cc
c
'c  c & $9c c:;$:<c =#$c+5c 6c
c
c

%c2  c2c ' c &cc  cc% c  c&cc && cc


 c'  +c.  cc. c c 'ccc"c #cc' %cc& +c
%c  3"c c 4c 'c & c 'c c c %c #c !&c %c && 'c c
&c&!c "c 'ccc
5+c ' & cc c c61 % c+c +c70089#cc
7+c c %c 2c '  c && c 'c 2c c  c
 'cc'cccc2cc
*+c  c c &c c c c %%c &'c  c c  c
  c %c c c  c %c #c c && c c & c 'c
c 'c &'c  'c c ' 'c c &2c  c 'c '  ' c c
 & cc cc c%c'cc 'cc'&'cc 'c
& "c%c  c%"cc
c

c c! cc. c'  c cccc%& %&c%c +c %& %c%c c
c . c '  c '&c c 2"c % %6c  !c 59#c  '": c 2c c %c c
;&"c & c c c "c '+c <% c !&c  &c c c c
%& 'c c c '&'c c c  %c ' "c & c c 2"c &c !#c c c
'&ccc%c '": c2cc cccc508c&'  'c! c c
!&cc%c '2cc% c'2c'& c%c&cc%c  c+c c
&%cc;&#c%cc&&"c2'c%& %c. : c % "c
'c:'&'#cc&'c!c&"cc ccc'cc c ccc & "c
 c  c & %c c % 2c '2c +c c c c   !c &c % c
. c '  c c #c 2c c %c   c !&c &!c c c '&'c c c
 %c ' "#c c &"c c  "c c 'c c c & c : 'c & c c
'c ' +c 2#c . c '  c  c % 2c  :c '2c c %& %c
& +c <% c  ' "c c c  c %c 2  %c c % c
%  c %  c %c =c  "c c "c 2c #c . :'  c
 c % c c 22'c c c 2c c c % c &'c c  "c c
+c c c ! c  'c 'c %c %c ;&"c  "c !c   !"c c
 'c %c %c   c &!c c c '&'c c &c c 2"c ' "#c
& c  "c "c && cc c2c%c%"c  %cc '2c+cc
 cc% c%  cc%c. c'&!c%#c& c cc >'c!"c
%c=c. :'  : c"c 'cc!c3&c c %&"c 'c c%c
  #c c ;&+c %c c %"c & c c 2!c 'c  c !c
2'#c c %& %c : c ? =+c %c ;&c % c  "c c c c
'c#c% c"cc c% c c c#c% c c c%"c @c 'c
c %"c  c c 'c & c && c c 'c  c 'c &c c
  #c '#c c #c % c 'c c & c && c 'c  c %"c % 2c '2c
c'&cc 2 cc)*@ccc
c
c
c
c
c
c
c

c'9c
c c
c c
 c  
c
c
c
c c
&cc 4c  'c+cc4c'&'ccA' "cc

1c 70000:B0000c

 &c%"'"cc $cc 50000c
'  cc 500:*00c
C:c 7D000c
(' c
%"c "c 7D0c
š:c%" & c B000c
%" cc E:c%" & c 800c
 :c%" & c 50cc*0c
&cc &c ''&c *c
&:&c "'c'c 80000:C0000c
 cc $ c 500:7000c
c

 
c c c
c  c c
c
''c $>$$c5+2c $2$: $c- $#cc c2$/ 2c52+&c
-$ccc#=$#c+5c#+& c&= +#c
c
cccccccccccccccccccccccccc
&& cc& c%c c% c!c&''c2"ccc 'c%& +c
%c  "c &'c c & cc %c $ c &c c &&'c"%"c c "& c
'c'c'2'& c% 2c%c && cc& c%c cc!%c%& c 'c
c 6Fc +c +#c 5GGB#c c +c +#c 5GG)#c ."c +c +#c 5GG*#c "c +c +c
5GC7#c "c +c +#c 5GGC9+c %c &'c & c   c &c 'c 'c %c
 &c c %c & c ;&"c c %c    c &c 'c +c %c
 "c  &c & c ;&"c c % "c   'c 4 Hc 63 c +c +#c
5GGD9cc4 c6,%c+c +#c700D#c
& c+c +#c70009c  #c%%c c&'cc
%% cc 'c  ">'cc& c& c!  ' c  "+c c%c
#c c  c ' 'c % c c & c && c %c c 6
& c +c +#c
7000#c3 c+c +#c7000c.c+c +#c5GGDcIc70009c 'c&%#c%c& c cc
% %c c 'c  c 6
& c +c +#c 70009+c c "c ''c & c && c !&c c
%  c "c c & #c c    #c  c c 'c '2'& c
63 c+c +#c7007#c "c+c +#c5GG)#c&c+c +#c5GGG#c c+c +#c5GC)9+c
c
<%"c 'c %c  c c & c  c %c c 'c c    c
 @c &c &'c % 2c %c c % %c  'c c . c '  c c 'c  c
6%2 c +c +#c 700*#c
 %c +c +#c 7005#c
'2 c +c +#c 700B#c '= '' c +c +#c
700*#c c+c +#c70059+c1&c%"cc%cc'  @ccc cc& c
%c%  c c &'c!"c. c c %"c! ccc 'cc
:c %c +c <c c c '&c %c &'#c %%c '"c  &'c . c
 c"cc"& c 'c'c
c
c
'0c $2$: $c- $#cc&#& -c2$/ 21&&23c
cccccccccccccccccccccccccccccc c 2c  'c ! c & c c  c #c
! c !c "c  %'c ;&c 'c '  c c ):%":
"+c. c c c c %'c! c c&'c&cc cc& +c
%c  c "c c c %& %c c  "c c c c  c c ' 2c '  c !"c
% c % c c c c &''c 6
c +c +#c 700)9+c
2 c c c
2'c ' c %c  c c %c  c "c c %c  c +c  c c
 c c   c c  'c ;&#c c & c c  c c c
 'c%c c&!  c' !> cc c6,  c+c +#c5GG89#c 'c
 c  !"c  c %c  c c %& c 61c +c +#c 7000#c ,%2"c
+c +#c 700B#c c +c +#c 700)9+c Fc  c  c  !"c  c  &c
%% c  ccc. c%%c c&cc 2 cc)*c 'c
%c  &c  2c +c c %c  c c  c % c !c  ">'cJcc 2c
 c%& cccc6 c+c +c700)9+cc c'c  cc 'c
%c  %:'& c c 'c  %c ;&"c  c ''c & c c
' c c %c  c c  "+c &c %'c c 'c c  c %c
  c c 2c +c %&#c %c c 2'c c : 'c  c c  Jc
%2#c c &'c c ''c %%c &'c '"c  &c  c   "c c
"& c 'c'c'2'& +c
c
c
'c $2$: $c- $#cc? #$c$@#+c2$/ 2c1?$23c
c c2cc% c c"cc. c '#c%%ccc
c %c c 'c &!;&c &c c %c  "c  'c c c %c +c 1 c
c  c . c  c % c 'c c 'c %c 2 c &&c c . c %#c
&%c c'>'c! #cc cc& +cc cc "c c
c   c ! c '  c '&'c !"c  2c " c +c 1 c c  'c c
c &!: % "c  c ?$2Jc c % c %!"c "c 5c &'c c
 'c c   c ?$2*c c % c %!"c 7K5*c &'c c  '+c
1 c c  'c !"c . c "" #c %%c  2c : ""c !'c c '  'c
! c 2 c &A "'cc6 $c9+c%c ! ccc%c'c!"c
$c '& c 6 $59c  2 c c  : ''c +c %c c c 'c !"c . c
" c !c 'c  'c !"c . c  c 6<c +c +#c 7008#c ' c +c +#c 700D9+c
%c%c!c%c 'c c %c cc&"c&'c2 +c &c
 c c%& %cc&c%c'#c&' c%c"cc#c%cc"c
 #c 'c%%c%ccc "c' 'cc 2"c'2' +6Fc+c +#c
700D9+c %& %c%c%c cc%& %cc!cc''c!&cc&'c
 cc'&!+cc
c
c  c' cc%c%' cc 2"ccC:c. c "" #c
& c. c "" c 'c%c'& cc% c c&'cc%c! cc'c
#c% c c%  cc!2'cc& cc 2"c6%c7007#c
<c 7008#c  c 70089+c
 "#c c 'c c  2 c 2"c  c !2'c c
%' #c 'cc ccc& c ccc%& c!! c
6
%c+c +#c700*9+c c'cc2c  "c  & c%c cc c"%c. c
&! c  c c cc %c%'c c c'cc1 c 2"cc
! #c2c 'c c c & c  c c'c c 6 c +c +#c 700*9+c c c
 c c 'c c c &'c c  c '&'c 2c c $5#c 'c
& c %c &'c ! c >"c 'c %c 2"c c %c 2c c
"& c  c6 cc +#c70079+c '&'c !&' cc. c" c!cc! c
 ccc 'c c% c!c'c6 !cc +c7007#c cc +c700*#c
,% cc +c700)9+c
c
c ''c c 'c >"c 2"#c %c % c c : 'c 'c c 1 c
 "c c c 'c c c . c '  +c Fc  #c %c c c . c
" c!c 'c $c'& c c'&'c!"c. c'  cc"& c#c%c
'c c %'c c  c c '&!"c 6 !c 70089+c F&%#c 'c c 'c
c %& c !! c c 'c c %c   c c  & c . c
"" c 'c $c '& c c !%c %c &c 'c %' c 6
>>"c
700*#c
>>"c700B9+c c & c' c%'c% c%c"cc1 c "c!c
;&:c%c%ccc%c c%ccc': & 'c
%c c ! c  'c "c  'c c c % c c c 'c !"c c 64&c
700B9+cc
c
%c !2c &'c ' c % c   c &c c c c c !c c
cc1 c 'c%cc!cccc' 2c'  +c2cc'c c
c!cc & c#c%c c%c&c' ccc
c c 'c c %c % +c %c c ' c %c  c !c
  c%  #c c  #c 2 cc)*c 'c  +cc
c
c
c
c

 "c p##$p#%c &p#'c!c $#(!%#c#) !'!(c#p!c*#c


c
 c 2c %c . c  &'c   c c '  'c ! c 6   c 70079+c  c  >c
!&"c c  &'c !"c   c &'#c 'c 2 c c !c '3 c "'c
& ccc&+c cc&%c 'ccc

c
c1A$23c% c&c
2"%c c %c #c 'c     
c 
c 123#c %%c 2c c c %c
 !'c 'cc 2c +c cc c&cc22 c&cc6   c70079+c
c K c . c '  c c  >'c !"c L$K 7*1c #c 'c !"c '  c 2 c !"c
L$ +c %c . c c &&'c !"c L$1c 'c L$.c 6 *c 'c  79c % c c c %c F c
!  c c c #c 'c%ccc 'cc%c'  'c 'c!"cL$Fc 'cL$+c%c
'  'c 'cc2'#c 'c cc'c!"c. c" c 'c. c +ccc%c2c
 % "c 'c  K$cc%c'  'c. c cc!2'cc c%c c#c%%c
;&c%c :cc
1c 'c
+c
c
c
%c %c!c c 'c  c% c c!c&''c!"c%c2 &  c c'& cc2c
cc%& c!! c 'c"%"#ccccc&c'2'cc'cc'c
+c
&'c& cc2cc"''c c&+c cc #c5GD8c'c c'&cc
&%'&'c. c"%c c. c'  cc c  c<:*Cc%& c!! c 'c
c "c  c+c<%cc'cc%c c cc&'c& c%c ccc
6$ c+c +#c5GD*9+c ccc&'"c6% c70009c &'c%ccc%c'   c
c "!& c "'c 'c 6$.9c c c . c c %& c !! c 'c 
c

c 'c c 2+c c %c %'c c c  'c %c #c c . c c  'c 'c
&! 'c %c Bc '& c #c %%c  2c %c . c c "'c '+c %c %c . c c
 2'c %c c >"#c   'c c c  c c 'c %c "c c %c ! 'c
' c c c c c ''c !"c
&%c %"!'> +c 1%c 2"c  !'c 'c
 2c cc  ">'#c 'cc c'c%c cc%c cc$.c2 cc&'+c
2 cc$.c c c 'c& cc&c  "c %c$.c !'c61"c700)9+c%c&'"c
%'c'&'c:'&'c$.c2 ccc 'cc"& c!! +c
c
  c &c !c 'c &'c  "c !c  'c !"c %c 2"c c c c &&c
'c&%c c&c #c 'c'ccc"c'!&c'& c c6 :1 c
700)9+c F&%#c  2c  c  "c 2 "c !c c #c '' c c %c c '+c Fc
 #c c'cc c%c  c  c c'&'cc"%"c'2'ccc
'c'c!&ccc%c"%"cc%c%'c'c6 c700B9+c
c

&'cc cccc&cc"& c 'c'c'2'& c"c%'c c'cc c


  "c %c   c +c  c c &'c &%'&'c . c "%c 63 c 5GC)9c c c  'c
 2 c  "c c c &cc c6<c5GG*#c c5GG)#c c5GG89+cc%c 'c 2 c
 "c c  'c   c % %c "  c 6 9c c  ' 'c %c c c '&c
. c '  Jc  'c c  'c c %c c 'c  c c  c 2"c  2c c
&'  'cc 'cc &'+c c  c&'"c& c%& c% c!'c"%"cc
5*)c'2'& c 'c70cc80c%'c c'ccc'  c c6<c5GG*#c c5GG)9+c%c cc
'c c & 'c c0+8*Mcc" #c%%c &ccN7)Mc' c2c cB0:" c'c6<c
5GG*#c c5GG)9+c%c  "c c&%c''cc%c c'cc ccc!! c
6 c 5GG89+c c ''c c '&'c  'c  2 #c c c 'c 'c '&'c c
 'c&!cc& cc%c 'c '+c%c& c% cc"c%c c!c
cc%c #c!&cc c cc+c
c
c
c' '2  cc 'c 2 c  "cc% cc'cc' c!c'c"cc
 #c 'c"cc%'&+c(%c  "c &'c%c cc2 ccc%'&+c
c &'"c & c Bc '& c c c 'c c $.c c % "c c 8c 'c 7Bc %c 'c  c
%'c% c2 cc$.ccc !'c c cB0Mcccc 'cc'c
 c % c c c  'cc "& c  c 6&c5GGC9+c c  #c %c : 'c 'c c $.c
2 c cc  cc c !'c #c%c"c%c cc$.c2 c ccc'c
 #c!&cc'cc%c&!cc$.c c&'c c7Bc%c6&c5GGC9+c1"c c c  "#c
 c "c c c . c  c 'c c !c c c !! c  'c c 'c %& c
'c6,&c5GG)9+c%&#cc  c% c  c% c c  ccc cc !'c +c
c
%c %'c c 'c c $.c 'c 68KB9c "'c %'&c 6$$9c ! c 2  !c %c
'2cc$.c 'c68KB9c$$:c !'c6c5GG59+c. cc 'ccc c:
 ' c 'c %"!'>'c %c !'+c c c %c  c &c %c %'c %'c c
' cc2 cc$.c 'c68KB9c$$cc' c!! cc'c%& c'c6&  c70009+c
.c c  c c 68:B9c $$c  c c %c c &'c  'c c 5Bc %c 'c  'c c 7c
%c 'c c 6L&c 700)9+c %c %'c  c &%c '2'c c &c $$:c !'c c
&%%"#c%%c 'c&'" c%c2 cc$.cc&cc%& c'c6  ' c
70089+cc
c

c c%c &c c c "& c 'c 'c2&c  c 'c c 1#c 'c !'c c 'cc
c c  ' +c %c !"c   c  c %c &'c c . c  c 'c !'c %c $.c
!'c c  ">'c !"c &%%"+c $.c c 2'c c 'c c Bc ' "c c
 ' cc%c"& c&!3#c 'c!cDc 'c5Bc' "cc'c&!3c6  ' c70089+c
c%c
c c $.c 2 c c c ! c c  c 'c ' c &2#c %c $.c c "c c !c
2'c c 'c c c DK5Bc ' "c !"c &2c c %c '+c %&#c c &c &'c &%c
& c% c c'c%c +cc
c
%c c &c &'"c %c %& c 2&c & c c : ! c %'c ! 'c c ;&  c c
%'&c!"c $4c&'c% c%'&cc: ' 'cc c'&'c c c% %c;&"c
c'c'2'& c6L&c70009+c%c c&'"#c%2#c''cc'c : 'c'cc c'&c
c  c'2'& c2  cc%c&'"c& c6 c70079+cc
c

 c p##$p#%c &p#'c!c%($#'p%c#pc*%'c#p!c

c
c.
1cc%cc% cc c. c+cc& '#c c.
1c 'cccc%c c
'c % c %c &22 c c %c +c ;& "c ' c c %c  c c  'c .
1c % c
' !>c%c c 'c 'cc c   +cc   c!cc
c  c c6.c5GGD#c3 c7007c#c&c5GGG9c& "c ' cc' & cc c
61 % c70089c 'c   +c
c
.
1c c . c c  'c !"c c  3c % c % &c ! c 6 9c 'c
% &c'c3 c6  9+c.& c :' 'c cc.
1#c%cc% 'cc&'c c c
 c c "c %c  c  c c %c !c &+c  c !"c c c ' 'c !"c ')5c
c%c%c%cc%c!cc ')7c c &c6 c7007#c ' "c700*9+c
c
c % 'c c ' c c  %c %#c . c '  c  c !c  'c  %&"c %c c c
;&+cc
c
c  #c %c   c  % "c "c &c c !c 'c %c c c c  'c c ;&c
% "+c  c c%c!' cc,&D0A,&C0c%'cc%c!c. c'c64!c5GGG9+c,&c
  c &c c :. K$,c #c %%c c %c 'c c  c %c c
 c64!c700*9+c#c%c c c'c!"c. c" ccLc "#c 'c2 "c3'c
!"c L B:. c  c c +c -$.c c 
c
 

c 
  c c

 c c  
 c  c

c c6!&2 c5GGD#c
 c5GGD#c
& 2c700B9+c.
1c& 'c!cc'c c c c
!c  'c !"c  : 'c   c 6

9#c c % %"c & c !  c% cc %%c


%c;&c!c%c cc''+c
c
c
%cc' cc : 'c%  cc.
1c cc%c c cc%c'cc
 c %c c 6.$%c 70009#c c  c c  'c %c c    c 'c c c
%>" "c 64( 9+c
;&c  "c c c    c c %c 4 Hc &c c 'c
  c c 6.c 5GGD9c 'c c c %c ' &c $ c &c c %& c "%"c 6F&c
5GGB9c ''c c 2 c  c c ''c % "c c %c ! #c &  c % c %c
   c "c% 2c&'cc&c  +c.c%c'&c cc.
1c c
c  c #c : 'c %  c c .
1c  c c &"c &'&''+c  "c &'c & c
2  c c %c c  "c '&'c : 'c 'c c %c "c c 3 c c L: ":
'&'c . c ! c c  c %& c "%"c 6 "c 5GCG#c
 %c 5GG09+c %c %' "#c
%2#c ''c c c '' c c c  c % +c
& 2c +c +#c c 700Bc % c ' 'c c
2c  "cc  +c%c  "cc! 'cc cc c  cF$c c&'c!"c
c #c   c  c c c %c  c & c '& c :
+c %c F$c c c %c
  c&cc 2#c%2#c'&cc.
1c!"c:
c 'c&!;&c ccF$c
2"+c
c  c c c%cc;&#cF$c 2"cc&'c2cc cc
 'c!"c'cc+c%c&!ccF$c2cc2c c c &cc  c
"#c 'c c!c;& 'c!"cF 
+cc
c
c
1.5.1c Does cellular senescence cause decline in NHEJ?
c
c ''c%c'"cc c c!c''c!"c;& c%c c'&+c c%c  "cc
&'"c : 'c %  c c   cc  c %& c!! #c c  c &'c % c "c c
  c c'&'c&ccB+):'cc:c 'cc 2cc"& c+c
 "#cc c
c % c 'c 3 c c 'c c  c  'c %c ''c '+c

c 
c  
c c

cB  c

c
c

c c
c
 
c c


c
c6
& 2c700B9+c  cc
%c ! c c "& c 'c 'c  c % c !c  ">'c & c c2c  'c 3 c  "+c c %c  "c
 >'c 'c c&! 'c%c& c #c 'c 'c  c& cc  c c
;& 'cc c +c%c  "c%'c% c  c"cc'&'cc%c! cc'c c6"3 " c
7008c c 700B9+c -$.c c c


c  c 
c  c  c ,

Cc 

c 
c  
c c
c c1
% '#c70083cc
c
<% cc%c& c% c!cc c 'c'cc  @c%c2cc,&#c%%cc
c c !c c  c 'c !' c c .
1#c % c !c %c c 'c  '"c c %c
cc  c c6c70089#c 'c"%"cc%& c'cc  c c6 &c70089+c cc)0Mc
'&c c ,&D0c 'c ,&C0c c 2c c c %& c !! c % c !c !2'+c
F&%#c & c'!&cc,&c''c!c"& c 'cc+cc"& c#c
,&c  c '!&'c %& %&c %c " c 'c %c &&#c 'c   'c c %c &&c c
c c €: ' +c c % c !c %"%>'c % c %c " c c "& c c  c ,&c % c
2c c c2c% cc&'cc%c&&c&c. c'  +cc #ccc#c c
,&c  c  >'c c %c &&#c c c '' c ,&c  c !c !& %c c %c &&c c  c . c
'  +c
c
2#c &c & c % c & c ,&c c c c c & 2  !c c  c c c c
6
& 2c700D9+c,&c "c!c 'c!"c&  !c. c'  cc6'= '' c700*#c
'2 c700B9c% c
&& c c %c &c c c +c ,&c %'c c c  c % c c  ''c c %c . c
 'c6< c70059#c 'ccc&c% c c,&cc%c. +c%c cc,&cc. c "c!c
 'ccc+c  2"#c,&c "c c c%c'  cc 'c%'c#c
%%c  c !c  'c !"c . c  c  %"c c c +c  'c & c    c 'c
. c!' c 2cc,&c% 2c!c'cc% c!'c& ccc 'c%& c6c
. c 700B#c F  c 5GGG9+c %&#c 'c c   c %c c  "c !c  &'c !"c '&'c 2  !"c 'c
'c  & c c ,&+c .&c c c 22'c c .
1c  c c  'c c  &c  c
%"c %c !c c! c7

c 
!c "c
 
!c 'cc'c
c,&C0#c. K$,c 'c 5c6!&2 c700)9+c "##$%&#%"'&()"%""#'#& *'% '#
+*,#* +"#*+# ' -*).  /-#/ 0*/0#'  %*&(* *1 '#, /* *1 '%+* 
%#'#*1%#// /'##'%#%#+*+*''(%0,+23
'4Ô #+(#%*&#'/#''#11%#
 , *&/ ,, "# '&# +")' & %*( #   &*# ' (/# ) * "# *'# *1 ,#
+"#*+#

c
c

1.5.2c RELATIVE USAGE OF DSB REPAIR PATHWAYS WITH INCREASING AGE


c c '&'c !2c .
1c  c !c  'c !"c %c 'c  % "c & c   c 'c

#c
'c
 "c:& c +c.c%c& cc.
1c c % "c%  c%c @c%c;&c
 c '''cc.% c c c6$c70089+c%c c 'c cc c%c
.
1c c  'c !"c &2"c 'c :
c '& +c %c  c 'c
'  c  c 2c c   #c

c c c !c c % &c %+c c c c


c % c  'c c 5BMc c "& c c c 80Mc c 'c #c %c c ' c ' c c

c 'c  +cc
c
 c %c ' c !c  >'c c    c . c  @c B+):'c ' c c   c c c
%& c!! c cc c!2'6
& 2c700B9#c%2#c%c c "cc'&cc c cc
#c c c c 2& "c !c c  2"c c c 6
& 2c 700D9+c 4 c c c c 0:
'cccc&'#c c cc'cc7Ac% ccc"c%c cc% 'c
c 2  !c 6
%:% c c 700Bc % c 700*9+c $ "#c c % &c %c  c !c &'c c c
 cc:'2' cJc%2#c c& c c% cc%c'cc &'cc;&c
% c %c &c c c c % 'c c    c c 6 %c 7005#c
 c 700*9+c %c c c
 'c!"cc% 'c! ccc"c c. c #cc cc% c% c
cc 'ccc 'c "c!c% 'cc! c %+ccc ')5cccc":
 & 'c 6  c 5GG8#c %c 5GGD9#c 'c ')5c !c &' !c %c c c  2c
c c 6
& 2c 700D9+c %#c %c  3c  % "c c  c c .
1c c    c 5A0c
c c   c 6 % c c 700*c
%:% c 700Bc
' c 70089+c <%c c c 'c c &c #c %c
& cc c  c c c  c  #c %%c c  c '2' c +c 2#c 2 c &'c
%c % c c c c 2cc !"  c c 6
9c c 'c c  "c !"c '2c 6(c
70089#c 'cc c'2 c c 'c c+c c%c!'"c #ccc'2'#cc
"cc'c 'ccc cc5A0c #c%c%c& cc cc&%c' +cc
c
c
%c  c c c % c c 'c !"c i#'* # /
. 5c c c !c % &c
%+cc   ccc! cc c 'c "c'  &c#c cc
c  'c %c 4c c >" "c 64( 9c 'c +c
c% c 'c !"c 1c
c64&c70009#c%c c"c6'c<'#c5GG)9c 'c c'2 c!c% c6
% #c70059c
&cc! cc   c+c4( c c cc &cc 'cc c 3c
!&c c %c c c &c 6
% #c 70059+c 2#c 4( c 'c  c 'c &c %c  'c
;&"c %c '2  c c 6.$%c 7000#c c 5GG79+c %&#c %c ' c c  'c c !c
% c c  c c  "c !c  'c c  'c ;&"c c ! c c ! c
2cc  c  +ccc!c% c% c& cc! c cc cc
 c#cc% c'c'2'& c cc   c+c
c

c &c %c c % 2c c % c . c  c % c 'c !c c c %c c 'c  c
  c c c  & c  c & #c c    #c 4( #c 'c & c
6'&'c  9+c %c &'c  c % c %"c &%c c c && c %c +c 1&c %c c
;&c% cc c% c %c& c 'c%c c  c'c && c%c c 'c
c % c @c c c c  c c %c "c %c &c c c  @c c "c %c
%c  c&cc  cc @c

c
F &c5c
: 'c%  cc. c c 'c%c;&+cc c 'cc c !"#cc& c 'c
 "#cc 'c;&"cc4( +c.cc"cc 'c'"cc1 c 'c c 'ccc& +c4cc
'cc:c  c&ccc& c 'c c   +c ccc cc7c #c%c& cc
&!c % "cc.
1c c6.
1 9c "c c%  #c%cc c!cc% 'c'#c 2 c "ccc
& c

c 'cc! c6 9c%c% &c%c ' cc c !"c 'c4( +c


c
c

c 
cc
c 

c
c
(2 #c%cc2'c% c #c1 c 'c  c 2"c'c%c #c !cc
"c    "c 'c %c c ' c !c %c 'c &'+c %c !c
;&c c %c : 'c 'c c 1 c 2"c c c & +c c : 'c
' cc: 2c 2"ccc'c c c!"#c%%c "c;&cc1 c
2"c % c c c "& c +c   #c c 'c
#c c c c c %c  %c
!c5GC0c 'c "c5GG0#c cc%c&c% c%ccc2'cc c' c
'cc. c cc. cc'& c  +c%ccc& cc2cc%c c
 cc c  cc%c+cc%&'c!c'c% c c'cc. c c
c c  "c c  c c && c c  c c %c  c +c
c !"c
 &c :  c "c c #c c &'c c &%c  c c
&& +c 2#cc%ccc' c c 2c&%c c && c&'c
!c'cc!c c %c% c +cc
c
c
c% cc% 2c'&'c&cc%'c 'cc  c%c% cc  #cc%&'c!c !c
c c 2'c % c "c c & c 'c  c &+c (c  c c % c c "c c  c
 % "c 'c c c 'c c c c c #c %c %&'c !c 'c c "c 'c
;& "cc& c!2'cc'c c 'ccc c'cc&!&&cc%c +cc
c%cccc!"c2c%c!2'c&cc& c && cccc  +c
c
<%c%c'2cc  c&c'c% ! c% "c  'cc
#c c ! c !c c '"c c %c %"%c % c  c & c c c & c
c && c%c cc'c c 'c&+c c%c/%&c'#c4c#
/+#c5GGB9cc%ccc' c c : 'c cc& c;&"c6'c c
%c &!c c & c c c c c &c c %c  c &!c c 2'c c
9cc#cc !&c*c50:)c ccc ccc'cc65K79cc50:Bc c7B:%:'c
 +c
%"c % #c  3c .Oc ' 'c : 'c  c c %c & c
;&"c c #c !&c c #c  c c %c &+c Fc  #c .Oc ' 'c % c
& c;&c c c/%6  c c%c cc%c2#cc !&cBc50:)cc%c
"& c '&cc !&c5)c50:)cc'c  c6 !&c*0c%9#c% c&%c c c c
2& "c !c c %c ! 6.c +c +#c 5GGD9+c c #c % #c 'c  c c %'c
 'c & c ;&c %c 6.c +c +#c 7000#c c +c +#c 70079c !&c c %c
6 c+c +#c70059+c%c :c cc& c && c c%c/%6
  c&BCCc c%ccF +7cc
c
7, #8Ô+*#* '/%6& 1#9 #%#')",#
(.#''.'+/##./0#."#.'&//#'#*1
"# /%6+/'& ',#% &%#
 "# /#' #+#'#
") % 0#' &%", &# &  1#9 #%#'
11##,#,* +'
 "#' 00/% 0#*1"#'#&%#.
'# * :  (". %#' 2: ' 00/  5
2
&*"' *1 ,#
 "' )' * 11## 1*& *
',#%%**/&/'*1"''
;<,#
/
.c
c
c
c
c
c
c
c
%c  :c & c && c !2'c c %c /%6: 'c c  'c c !c
2"c  c c % c ! 'c !"c %+c Fc  #c &"c (c 6
' #c  9c 'c :
c&'c%c  c! % cc&c'c 'c!"c ccc c!2'c c
: 'c  c c /%6 & c ;&"c c 2#c % #c 'c #c !&c 2& "c c
 cc! c 'c6(c+c +#c70009c c
& c#/+#c670009#c  "> c%c& c
;&"c c 2#c ! #c 'c ! ''c c /% #c !2'c c &:c  : 'c
 #c%c& c &&  cc2#cc '"cc! ''#c!&ccc! +c c& c
%c%c#c c#/.2+c  ">'c &c& c;&"cc''cc
 c '&%'cc%c&#c c50#c5B#c5D#c7*#c7)#c 'c*0c%cc cc 'c&#c2#c
!&#c 'c c c+c%c &%c!2'c2 cc%c& c;&"c
%c cc 'c&c 'c2#c!&ccc!&cc c c#c%!"c' c
'c  c %c &c "c 'c !2+c & c && c c  c c
c c %c % &c c %c &c  c &''c c %c  ! "c c < c c +c 65GGC9+c
 "#c c  c 'c c & c ;&"c  c !2'c '& c   #c
%c c &!;&c  c c   c c ! 'c c 'c +c %c & c
;&c 2& "c ! 'c c 'c c c  c c %c c ! 'c c %c
'c &'c 6 c %c "& c c 'c 9+<% c 2 c  ! c 'c c
 "c c  &c & c ;&"c c !%c ! c 'c  c c #c %c
c c !c &c % c c %c &c %c c c  c %c c 6c c 2"c  c
9+ #c c c !c % c %c 2 c c !c c & "c  &c /%
& c c&%cc2c% c%#cc%%c c%c  : 'c c 'c
'c!"c%c2 +c
F &c *c c  c c "& c 'c
'ccc%c"cc& c&'c
c && c c %c /%6   c
&+c c % c c %c  c c
6
9c2& "c c&%c& c cc
& #c !&c c c 2c 649c c % c
6 9+c c c %c 2& c  c c
c   cc! c619++c
c

c
c
c
c
c
c
c

c! % c'c'cc' c c&'c cc&c"c%cc


c %c  &c & c  +c 1"c  #c c %c /%6: 'c '#c %c c +c
70:'c c  #c 3c.Oc!2'c c c"c%ccc%c
&  c  c c %c 'c  +c & c c %c /%6 c &c 'c  c !c
%  >'c!"cc' c 'c&'c;& cc%c2"c'c/%6:
& c  'c 2'c c c &c &+c & c % c 'c c c %c c
 c cc& P c! c%  cc2"c c'+c& c% c &c
%  cc%cc c c'c 'c%c"cc   +c("c ccc
%cc'c%c%c/%6 +ccc%c& c  'cc22c c
   c !c %c /%6: 'c &c 'c %c &c % c . +c c
'#c &%c 2c  c !c %" "c %  >'c ! 'c c %c  c &c  c
% c' c%c! cc%c&c +c  '"#c!"c"c   c& cc
%c ! cc %%c c c%"c %  'c %c :>"c  c c%c c  #c
 c  c c c !2'+c Fc  #c % c c% c 'c 2c!%c c
& c 'c c    c c&'c c && #c c  c c %c :
 'c c c"c'&ccc& 6.cc +#c70009+cc
c
F&%c%  > cc%cc& c!"c&'c;& ccc& c/%6
c! 'cc'c c c"& c 'c'c c' 'c% c "#c c"& c #c
%c & c  c c c c c %c  c c c  +c 2#c '& c  c %"c
 'cc'2 c  "#c& c c'c cc' c'c!c #c%c c
% %c;&"cccc c! : c&!&c cccc:c #c&%c c
! c 'c% #c 'c cc2 'c cc%cc 2c&+c "cc! c
'c% cc'c  #ccc c c& c cccc' +c& c
c c " c ;&c c %c  &c '  c c ):%""+c F&%c
%  > cc%c c   c c;&'c&'c;& +c<% c
c&c&'c!c' c !&c%c &cc&%c& c! 'cc%cc
 #c%  > cc%c! cc%c&c c 'c%c' c c
'#c 2#c c   +c
&%c %" c   c c BGc :   c
& #c  "c c % c 'c 2c c "& c 'c 'c #c ' 'c  % c
'c c 2#c 2 " c c  c % c 500c !c c 88c !#c c c c   c
2+c c  c cc%c;&"cc%c c   c%c c c
&'c c % c 'c 2#c !&c c c ! +c & c % c %c /%6  'c c &c c
 2c c %c 2 c #c  3c .Oc   'c %c c    c
;&cc%c*:!c/%6  cc%cc8cc50G:!c''c +c%c&c
 c&!;&"c'2''c!"c c cc#c! &c"ccc%cc! c'cc
&c c c /%6 c +c %c &c ' c % c &c c *Dc 6c %c 'c % 9c c
   c c && cc c 'c+6.cc +#c5GG)9cc
c
%c c &c   cc  c "c c %c  c c & c && c 'c
%c"cc& c&'c'& c%c&cc%c  c+c cc  ccc% c
%c& c;&"cc"c c&cc :c: 2c 2"+c''#cc
c   !c c &c % c %c % %c  2c 2"c %c c c % %c % c c
 c#c cc%c  3c % cc & c  +c %c &'c  c%c
 2"c% %c& c;&"cc c#c%%c c !&c):'c'& c  +c
c'cc #c%2#c%c 2"cc c 'c cc#c 'c%c !c
c c ccJc!%c%c c%&'c c"cc 2"c  c+cc
 2c 2"c c c  #c %c c c c c  c %"c & c && c c
% #c c:c c c+cc2c c ccc%c&#c  c  c
  #c 2 'c %c !"c c  : c 2  c c %c c &c % c c c
' cccc& c && c%c% %"c 2c cc 'c%c:
c! +c1"c   c%cc cc& cc%c#c%%c "c c%c
 '"c '2' c % c #c c %c &c  c c  #c c  "c c :#c %c
&c #c %c  c !c c '"c  c %c /%6 & c ;&"c !c
  c 'c :'2' c c c %c  c c 5C:%:'c +c %c &c ' c
  "c % %c & c ;&c c %c % %"c  2c & c % c c %c  c
6F +cB9+cc%c& cc%c& ccc& #c&  c cc
c %c &+c 2#c  c   c c !2'c c   c  c c /%6 & c
;&"cc%c #c&' c%c c% c. c ccc"c "cc
& cc && c%c +c
c
c
c
c
c
c
c

c
c
c
F &cBcc& c% 2c && 'c%c cc
%c& c% cc%c cc%c cc
c5C:%:'c+c%cc& c&'c
c && cc%c& cc cc& c
6%9+6c  #cc 9c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
F &c )c & c ;&c c % %c c %c
%"%  &c 'c % &c % c c %c %c
! +c c %c  c c : 'c & c
&& c c   "c % %c c %c
&&+c 1 c ! #c "& c Jc %c ! #c 5C:
%:'c Jc  "c ! #c *0:%:'c +c
6  #cc 9c
c

<%ccc%c! #c  c c'cc%c!"c% c%cc%c2 c c


& c c c 6c "c "9c &&  #c  c &!:&&c &'c 2%c
%c  'c & c %c +c ''#c %c &!'2' c 'c ! c  #c %c
!2'c % c c %c %"%  &c 'c % &c & c c &&  c %c c
%c %c & c ;&"c % %c % c c %c ! c 2 c c c c 6F +c )9+c %#c
 c%c% c. c c#c!"c"c 'cc%c&cc c & c
 cc&!:&&#c c"cc "c ccc' c%c cc c !"c
c%"c c'& c  +c  c1&&#c2 "c' 'c% c& c'cc'c
 cc%c'&+cc c''cc%c"cc& +c
c
%c &c c !2c &'c  'c c &c c & c ' c % c %c c
 c&cc!%cc 'c'2 c#c%2c%c"cc  c'c''c
c"c%%cc cccc+c 'c%#ccc c% c!%cc 'c
& cc 'cc %c%+cc
c
c

 c  c c c


cc c
c cc
c. c'  #c%%c c!c >'c 'c 'c%& %ccc%c % "cc%c
cc :  c 'c: c"#c. c& c'&cccc % "#c
;&c %  c  #c " c %  #c c c c  c c c
2!+c %c  c %c c &c & c 'c c %c  c +c 1c c c
& >c%c'c"cc c  c% c c&cccc  c&c 'c
%c2'c% c%"c && c%c c00*#c 'c!"c'&c%c%'c% c&%c
%  c&'c!&cc%c  c%"+cc
c

 c +(##! c &p#'c
" c%  c c c  c% c c!c2& >'c!"c %c"cc#c
&& "c '& c  % +c %"c &'c % c ! #c ! c c %c
&&c c &!c c %#c 'c  % c  #c &%c c %c
 % c. cc% c && cc" c'& c 2c  +c cc
c % c ! c c & !c 'c 2c c c %c  c %&c
':  %c  c 6%#c 9+c %c c 'c c
 +c <%c %c c '2'#c c c %c  c c &''c c %c  c
' & %c&c 'cc : 'c &c%c %c " #c%c c %c c c c
3&c%c%c +cc
c
" c  "c c 2'c 2'c c c   c 2c c c  c c c
 c &c '& c  c  00*c 6&c +c +#c 5G8*9+c ë c c ë
c
 c c  c
c

c  cc c  c
 c  
c

cc   c c

cc
c  c <%c  c  %" c c  % c  c c %c : 'c   c
% "c %c c &'c ' !"c % %c &!c c c %c ! c
%cc'c  c% cc"& c  c6c !&c50Mcc%cccBK):%:
'cccD)Mccc'c% c57c%9+c
c
4 #c &%c   c && c %  c c . P 
 c 
c c
   c  
c   c c   c c c  c c  c 
c


cc c 
c% c#cc !&c7KBMcc%cc " c%c
! cc"& c'2'& cc !&ccc c% c%cc%c'"+ccc
2 !c % c %c % c %  c c %  c c %c % c
c+c%cc&ccc '2 'c%'#c&%c c%c  #c
% c "c'c%c cc" c'  c%c cc"%"cc
!%c %& 6 "c c +#5GG)9c 'c 6&c c +#c 5GGG9+c c %c c
&"c&2 c&c% c%c;&"cc" c%  cc!%c%& c
'c &c c  c %c +c c "%"#c %%c c c %c "c c "c
 '"c !cc&%c' #c%c;&"ccc " cccc
c&%c ! c'cc  ccc&%c% %c% c +c50M+c
c
2#cc%&'c!c >'c% c2c%c%cc"c 'c%c  c
%'#c %c  c !c "c c ! c % c  c c !c ''c c 7c c !+c
D cc c 
c  cc cë c c   cc   c
 c c
 c ccc

c cc c  cc   ccc  c


 
c c c 
c c  c 
c   c  c   c c 
c
  
 c  c   
c  c c c  c c

c
&'"ccc' 'cc&c% c%cc! !"cc&c% #c&c  "#c'c
c  c c ' c c ''"+c &'"c  c % 2c  3c '2c c %& %c :
 'ccc%>" "c64( 9c'&cc%cccc%c"+cc
c
c%c&c!"cc% c!c' 'c% c2c*0Mcc& c cc' "c
% c &'"#c !%c c 'c c c %6 %c c +#c 70059c +c %c % %c
;&"c c % "c ! c &c  c c &'c c  c %& c ! c & c
% c&c ' %"!'> c 6cF
9c %c !cc%c 756 %c c
+#c 700)9+c c %c 75: &'c #c &' c :& c c 'c &#c c
%cc&c !&cBMcc%c 'c5cccc%c%& c! +c
c"cc
&c c  ">'ccc"c% c%c2 c cc &'"cc%c! cc&%c
% %c % c % +c %c c c  c  c %c %c & c c %& c "%"c c %%c
"c0+8Mcc%ccc%c75: &'+c &c "" cc!%c%& c 'c
&c "%"c 2 'c &'"c c "c !&c *Mc c &%c +c <% c c c c
c %%c %c ;&"c c &'c c c %c ! c  c %c #c %c % %c
&!cc &'cc  '"cc%c! cc '&c' c% c&c cc&%cc
 !c% cc%& %+c
c
c
c ;&c ;&c c &'"c c c ' %+c 2#c %c ' 'c &c c
&'"cc&cc  '"c' c% cc' %cc!"cc c2 !+c''#cc
% c "c !c ' 'c % c &'c &c c & "c 2c 'c  "c
  'cc! c&"c 6 !&"c c +9+cmc  c c c c c  ccc
  c 
 c c  c  c   c c c 

c
c c   c
cc c

cc ccc 
c c 
 ccc(c
 "c c%%c%c c c!&cc'2'& c%"  c 'c!% 2 c
2  #cc!ccc+c%&c c%c;&c c& '#c!&c cc&'"c
2'c c  c 2'c % c   : c c 2  c c  !c %c c
'c c c c % c %& %c 2&"+c Fc  #c  c c %c  :&'c
"%#cc%%c%c% 2c!c2c50c#c''cc%c%& c #c  :
 c":&!c"%c% c!c!2'c  c'2'& c 6  c c +#c700B#c
! c
c +#700B9c 'cc%& %cc  "c!&cc c'2"c 'c' c&!"6F&c
c +#c 700)9+c c<% c c c  "c!c % c c  'c c  c !&c
2"cc cc%"  c&#c&%c c%c''cc! c&"#cc
c   !c c c '2c c c c  +c %c &#c c c %c % c
 c c% 2c cccc&#ccc 3ccc%c;&c% cc
 c c %c  c %c &'c  'c c  c  'c c c c c c
%"  c%  c% c& "c! ccc c'@c
c
(!2 ccc& c% c% c ! cc& ccc && c
'& c  #c 2& "c  c c c &%c +c Fc c c %c  c &"c c  c
%& %c % c %c '&c ! c  c & !c c  c c &#c !&c % c &'c &c c !c
 +c 6 "'c c +#c 700)9c
%c $&c 61& #c #c 
9c 'c :c  ">'c
&%cc)D1A8Q.1 A7c%"!'cc cc%c cc c  cc
&& c c !"c   c &c c c  :c &'c "%c !c %c c
&c c61 "cc +#c700B9+c c&%c"%c#c%cccc c' 'c4( +c
c c&'c% c% cc5)c&%cc"& ccc'cc''#c58c
&c c 5Dc &%c c 'c  c ' "'c 4( c c c c c %+c %c
&c c %c  c &'"c c  "c  c c %"c ' c %c && c c
% c& cccc c#c c c2cc:! 'c% c
c  : 'c'  +c
c
%c &'c c ' c % c   c %  c c &c %c +c c %c
2c &'"c c  'c c c ' %c c  &c %+c $:c 'c c
cc!cccc" c%  +c
#ccc cccc'c%c c
 c%c'  c%c'cc  +ccc

 c  
c


cc c  c c  
c c
 
cc
c
c c  !"c %c % c % c 2'c c c c c c %c +c c
% #c'&cc%ccc c c#c% c!c!2'cc&c'& c
 'c    c c %& c c c &&#c %c  &c  2c c  c  c 
c


c  c c 
 c c +c c %c  c  c c %  >'c !"c % c
! #c ' 'c !"c '::'c &+c %c &c c 2'c !"c 2 c c )*c
cc'cc!&'cc& c  c c >'c c.
1c. c'  c)*cc
2 'c c c %%c  'c %c c c c c +c %c  c c
 c c 2 c %c c &''c !"c %c !2 c c %c  ! c c<'"c
< %c 'c "c
% "c 6!%c c .  #c L#c 
9c % c c &c 2c  2c
c 'c "c >c c%& cc61' cc +#c5GGC9+c
c
c c c 2c c %c  c c c  2c c c c  0* 'c c  c
 #c %c c  "c 'c c  c2'cc  c c c  3c 'c % c
%c c  c : !"c "c c 2"c   c %& c +c c  c
 cc  c00*c&''c!"c%c!2 cc &c  ccc%c
c 2 'c c  cc 'c c&!cc& c&'+cc
c
c%c c''c'" c  #cc% cc  '#c 'c c
% 2c  &c c c  "c : 'c ' c 'c  "c ' %c 6& "c c +#c 700B9+c c
%c "c 2'c c c c  00* c %c c % c c  c !c ''c c c
 3c &cc  #cc #c%& %c 'c 2c@cc %c
 c !c  &'c c %c  c  %c c  c c  #c %%c 22c c
 ' 'c c
&%c!c%c cc c''c!"c%"!'> cc
c!c  cc +c<% c  2c%'c  c%c &c
c  c c c  c '2'c 64 'c c +#c 5GG8#c 1 'c c +#c 700*9#c c '  c c
c %c'& c  cc! 'c%c  "cc cc +cc
c
2 cc %cc%c!'cc 'c%c&cc%& c% 2c!c &'c
!"c c&!cc &c 'c&'cc'cc +c57+7c!cc c&ccD+7c!cc cD7:
" :'c61&cc +#c5GGC#c >cc +#c5GG*#c  c5GGC9c+c%c  cc c&'c
c&c c 2"c"& c +cc'2'& c% 2c!c&'c%c c cc %cc
c% c)c!#c2c  c500:" c'+cc"#c& c c;&  2c$ c%'cc c
&'"cc5B*c c& 'c'2'& c2c%c cc80c" #c c  c c&'c
!c c  %c c !'c 'c  "6 %c c +#c 700*9+c 2#c %c  c c
'cc c c&'"c22 c)GCc c'2'& c2cC)c" 6 c700)9c
c
<% c c c %c ;& !c %%c c c !"c c % c %"c
;&c00*#cc%&'c!ccc'c% c 2 cc %cc!'ccc%c
 c c %c 2 c  %c c c c c '2'& c c c %c %c c c c
'2'& c %+c #c 2c c 2 c c  %c c c c'c c &22 #c
c c &'c 2%c !c c c  "c 'c c c c  !"c
!& c c  c  #c c %c c  #c c  #c !"c & c c c  'c
&!ccc+c
c

 c %pc
c c
c c cc%pc c
%c58+):!c%' c c% c!c 'c c c 3c  cc c& c
'& c  6 "c +c +#c 700)9+c ' cc%c%' c%"cc  c c& cc
. c && c%c c c c;&cc%cc ' c  'cccc%c
  +c%c& c'  2c%  cc%c cc c c%c'cc
&cc 'c&cc%c "c% #c ' cc 'cc ' c'&c
'c c & c c . c c c c c & c . +c %c &'c  'c c  'c
c% c 'ccC:ccc& c. +cc'  cc'"c c
&cc& c#cc 'cc' %c!"c % "c2  cc)*+cc%c c
c %c 2&c "c % c  'c  "c c  c 'c  c %c  c
 'c c %c . c c c   c c : 'c & +c 2#c c c % c #c
"c! 'c&c%'cc'&!cc2&:"c' +c
c
%c c cc'c%c%' c c c c c  cc  : 'c
 &c . c & c c c %" c "c c c  3c &c c c  ' #c %c
 c c 2c %c #c 'c %c &'c !c c . : c "+c
2#c%c cc&'c&ccc!c"cJc2 c c % "c% 2c!c
'!'cc. #cc !"c cc1 c"#c 'c!"c c %c c
'c!  c 64 c700)9+c
c
2%#c %c c 2'c c c  2"c % %c &!"c c . c c ' 2c . c
'  +c  c c %c  'c 2& !"c c . c '  #c %' c c %c "c
 cc c%& %cc c 'c' 2c%%" #c  & !"c%c
c c& c&cc& "+c
c
''c !"c %c %' c c c c   #c 77c   #c 'c c ' c 5*c
%' c c &!&+c %"c c  "c c '&c  c >"c c
22'cc' 2c%%" +c 2#cc%' cc c''cc
%c & c +c <c  "c #c % c c %c 2'c % c & c c %c %' c
c && cc c2c% c c!& cc  : 'c& c'  c 'c
' %@c
c
<%c%& c& #c%c%' c c% c c% %c cc;&c'2 c
%c&c"%c2  +c%c% c'ccc 3cc c ccc  c%& c
2& "c%"+c. cc%'c&2"c%& %c%c%c 'c c&!cc%& c
% !c ' c c  &'c !"c c & c c %c %' c +c %c
& c" "c c' 2c "c !#c & c&%c  : 'c' c c
 '" %"c 'c &'  +c
 c c  c %&''c 6% c 9c c
%&''c c %& 'c 6 '""9c c c c %c %' c c c c 'c
' : & c& c cccc"c c cc%c +c%c& cc 'c
% "+c c & c c  'c % c %c c c  'c !"c c c c %c
%' c +c & "c %c  c 2"c c %c ' c c  'c %c %c
c c %c & 'c . c c %c   c &+c %c c c %%'c !2c %%c c
' c%"c!c  c6  c700*9+c%c%%'c "c!c80Mcc'c
'c c % %c c G0Mc c c & +c
 c c %c & c %c & c . c & #c
'c% 2c c% %c c! &c%"c c c  c cc%c%' c +c
2#c%c!"c c!c&''c% c%"  cc c c;&cc
''c%' c cc cc c70M+c
c
Fc c& c  c%c c%c& cc2"c cc%c%' %+c

 c . c 'c  c %c c c c &:c  6 %c 5GG79+c c
 & #c &#c % #c 'c ! c && c  2"c % %c 2c c''c . +c  :
 c2  c% c!c' 'cc%c! #c%c c && cc%c#c!&cc
c %c !&6
 c 5GG79+c #c %c & c c % %"c c c % c % c !c
!2'cc& c. c%c%c/%6c#cc%%c c c:c 'c :
 c2  cc& c && c% c!c!2'+c cc%c #c%c;&cc
%%ccc%c!2'c& c;&c c 'cc%"  c;&+cFc
%c& c c%c;&c c "c!c '''c c%c #c!&c%c%' c
cc&%c c 'c 2"c "c !c'&ccc% %c"c&!cc+c
2%#c  & c & c c %c %' c c  c % "c
%   +c
c
1c c& c c% 2c c%"c;&#cc&cc "c '+c%cc
c c 2'c% c %' c & c c"c && c %c #c !&c  c c
 "c  'c c  %c 2c % c  "c !c %"  "c   +c 4c c  "c &'c
 c c 'c 'c ;&  c :;&"c 2#c c %c 'c c % c c !c "c
 &&cc c%cc% c% c!c'+cc  "c c! 'cc$ #c%%cc
&"ccc  +c
cc%c!ccc  "> c. c& cc  cc!"c
,% c c +#c 65GGG9c #c %c '2'c c $ :! 'c %'c c  c   c  c c
%' c c c  c +c  c %c  "c %c ' 'c % c c %& c
 '""cc'c!&ccc"& c'#c. c'c&c c c;&"cc
!&ccc5)cc61'" c70059+cc&%cc''c. cc'c&cc8)Mcc
%c c&!cc#c %& %cccc%c c c&%c+cccc
%c'c% c c!c'c!"c%c &cc.& c&!&c6 c&c"#c,9c 'c
&''c c6 '#c<#c
9+c&!&=c &c c%ccc' c. c'c
& c c &c!cc c'"c &!3c %c 2"c c 2"cc "%c c
' c 6 c  cc  ":% c'"9#c & 2c c c . c '61"c 5GGC9+c
=c &c!2'c "cc'c& cc%c%' c cc'2c
&c!cc 'c 6 c 70059c c 'c%&c"6"c 700B9c + #cc%c cc&c
%c c c 2'c % c . c 'c  "c & "c  &c 'c c ' 2c
%%" +c c '  c c ,% =c  ! "#c & c c 2c  :&c $ c
 %#c' c% %c cc''c. cc"%cc' :'c&c
c%c&!  c  cc'"c%& 6, "! c70089+c
c
Fcc& c%c& ccc 'c! &c&%c& c cc'&c
c'+c  c c  c  :c$ c  %#c,% =c &c ;&'c !&c)Mcc
%c%' c cc c&!cccc&c c'2c c!& c%&c 'c
% c&c! 'cc'cc'c 6% 2 c70079+c%"c'2'c% c "c
c  'c % %c c 62 " c c !&c *0c c 500M9c c  c & c . c
 ''c c  c  c & c . c &+c & "c c  ''c & c c
!2'c c &c c '"+c %"c &''c % c c c 'c %& c !'"#c %c c c
2 c  "cc ''c. cc& cc+c
c
%c % c :c #c &%c c  '""c c &c !#c &!&=c &c
 ">'c cc"#c c& ccc'2'cccccc#c
c. c& 6 "c700*9+c%"c;&'c%cc%' c cc'2'& c
c "c ! 'c !"c  c :'c c '"c '2'& +c $ % c c
& cc''ccc!&cc cc%c"%cc' :'c"+c
c
%c;&"cc&%c"c 'c%c c%c' c&c cc  ccc
. c& #c&' cc& #cc  +c

 "c 
cc c   c
%c c c  c c % c c &%c c 3c c c %c    c c
c c >'c&  c%c+c
cc%c c c "c c cc
c %c  & c c :c  +c c  "c c 5G8G#c "c1c 6 c'c  #c
 #c
9c 'cc. 2'c6$  ' #c #c
9c'c% ccc''c. c
 #c %!"c & c c  #c ' c %c c c ! c c c
22'c c '2+c %c c 2'c % c !%c %c !c c c 6 "c
 9c 'c #c  'c  c c c & !+c
&%c  !"c &'c c
 'c2& "c%  c c%c2cc c & c %c% c%& %cc&& c
 +c <% #c c "#c 2'c % c  'c c c c   c % c c c
'' c "cc c & c%c ccc'  c c 'c ccc%c
 c c cc%c Jc% c#c c 'c 'c +cc
c
2%#c c c 2 !c % c : 'c  !"c c %c ;&c % c '2c
cc c cc c & +c%c cc 3c cc #c
'c 4
c 'c

#c %c 45c 'c &#c 2"#c c %c  c  2c c
%& +c 45c  #c %c "c 2c %& c !c #c 'c %c  %"c c 2c
!%c c 'c &#c %%c c &%c %c 'c 'c c  c c c  ' c  +c %c
  !"c c &%c c c  c % c !c ' 'c c %& c c
6,! 'c c +#c 5GGG9+c %c "c 2'c c !%c c 'c  c c 45c
c c &c & c  c c c %c ! c c c c c &%c c  0* )'
*(#+c %c  c c2'c % c45c c&'c "c c c c c
%c c c c ' c c %c & c  c +c c % c c !c !c c
& "c'c %c;&"cc %c c2#c %%c  "c 2 "cc c c50c c
c c 5000c +c #c %c c ! &&c 2'c % c %"c !&c   "c c
 c !"c 'c% ccc !&c c!c cc c 2"c%c
6 %c c +#c 70079c +c %c &%c & 'c % c %c !2'c 45c  c &'c
2"c!&cc! c "#cccc"c% c&%c2c&'c!&cc%c
 'c && c c & c c %c c c !"c c '2c +c ''#c
2cc45cc 'cc"c61&=%c c +#c700B9c 'c45cc !cc'&c c)*:
''c c6 &'c700B9+c2#c45cc "c'cc%c c
+c c c 2 c c 2c c  c c  "c !c c ;&c c
%" 661&=%cc +#c700B9+c
c

 c #
 
c
cc  c
c%pc 


cc  
c c
c
cc
c
%&c #cc&'cc c  cc  c% 2c&'cc. c'  c6% c
%  9cc& c6;&c%  9+ 2#cc 'cc ccc&'c
c %c&cc%"c2  c% ccc! 'cc2  cc%c! c;&c
c. +c
&%c: 'c c2  cc% !c c''c!"c' cc
c 'c % c c % c c c +c %c && c ! c c
 c 2  c 22c . c %" c c %:' c  +c  c
 cc"c  "c !c 'c''cc%  c'& c'2c 'cc " c
&c c  c&+c #c c &'cc!c & c c % c%  c c %c
 c&'c &c c !c c 2 c c c c  &c c  c % c . c ;&c
%  +cc
c
 c cc cc% 2cc!c&2"c%cc!c cc
%c  & c c c+c c !" #c %c  c  c c  'c
'c #c '2c 'c ' c c   "c   'c !"c  c   +c
'c %  c c %c c c &c& c 'c "c c % 2c '2c #c
 cc%  cc. c;&+c 'c& c!"c !c ' "c6
"'"#c &  96c
' "#cc +#c5GG59#c%"c% 2cc!c' 'cc!c "c c c & c c
c 6F! c70089+c
c

  c &  


c  
,c
c c c%pc c
<%"c 'c
c c '!&c &c '& c  @c %c c  "c c c %c
 c  c c %c  c c % c c    c c  !"c 'c
   c . c  +c .& c %c . : c #c % c 'c c !c & 'c 'c
 !'#c%%c% c c c&cc%c c 'c"cc +c(c!"cc
% c %c  > c c
c c c c 2c 'c c % c %c c  c c
 !>cc. +cc5GGG#c&c&'c%'c% c c c. c! cc&ccc c
. :'  :%c c % c  c
c c c   :"c c 'c
c 'c  >c %c c %c . c ! #c !"c c   c %c  c +c
''#c c. ccÔ& c c%cc!cc&!cc& c!"c c
' &"c'c %* c'& 7)+c 2#cc'cc. c':3 c c
!2'c& c c ':! 'c  "78#c c' "c% c "c!c 'c!"c%c cc
% cc 'c. +c%c' cc%c%c!2 cc"c 'c &#c%c
&'c% c
7c 'c%c%c' " c'"c%c% c% c&&'c%c! c
cc c "c' 'c #c%%c  cc!c c;&ccc +c
<ccc%cc c%c > cc% :'" c c6 9c+c
c
%c '  :' 'c  > c c
c c  c c % 2c c c c  :c
c  c  c c "& c " c +c 2#c %c && c c . c '  c
'c 'c. c !"cc'c" cc2& "c 'cc c%c c#c
 cc c 'c2!c c%  +c ccc. c'  cc : 'c
c !"c% c c!c'ccc%c% c%c. +c. :! :'&'cc
c%>" "c c  "c  'c%>" &cc c&'cc c'   "c
%c c '#c'' cc%c&#c c  2 'cc%c !cc
7#c c'  c c
2c c c %% +c 1%c  'c &!"c c . c '  c 'c c
&& c c '2c . : c >"c  %c  c %c  c  c c %c
! c c !"+c
c
c

  c $ c c c  


c  c
<
#c $
c 'c   c     c 6 9c c  c c  &c  c ''c % c
' c!%c%c'  c;&cc'cc& c %&c 'c%c'2c
c c c % c c 22'c c c   +<
c c %  >'c !"c c c % c c
% %"c& !c cc%c cc& c Rc% +c $
c%c cc<
c
!&c 'c c  '"+c(c c  &cc $
c c c  c ! c %  c c %c 
#c%%c'c c #c c c&& ccc%c& c! +c%c
& c  c  c c & 'c c 2  c % c '&!c %c &&c c %c
& c! c 'c &c  c%  cc%c& c %&+c&cc c
%c $
c c %  >'c !"c c '"%c % c 'c c c c %% : 'c
c % c c  'c %c %c & c ! #c &%c c %% c :5c
6 $59#c cc c 'c%:' c c% cc c  c'&! ccc
%% c15cD3+cc
c
c%c ! c c c2c%c&& c'c% c c" cc
$
ccc&&#c%%c' c c'c & c %c!c%c c
'c $
+c %c & 'c  c 2  c% c c !c&'c c  & "c 'c %& #c
%%c c%  cc c cc%c c  c+c c2'ccc c c
c%c  cccc%c%cc' c% c& ccc%c 'c
#*"('#/#,' c%c%  cc%c& c %&cc 'c  #c 'c c
c c &c & c c %c c % &c c  c c  &c c ' c c c
 "+c 4c <
c 'c $
#c c c %  >'c !"c c '2c & c %&#c
 2c &  c '  #c %c  ' #c c  !"c 'c  &c
 +c $ c %c c % 2c c %'c 'c c %c c & 'c 6 9c #c %%c
'c c c  c % c  c %c . : c   '+c . c  c 'c c c
 & c c c !c ;&'c c c   #c 'c '2c c  c '&!c %c
 c !c c 'c %c & c  +c %c !&c c %c c c c
 % "c  c & c 'c c  'c !"c %c   c c 'c % c c !2'c c
:'2c +c %c " c c % &c 5c % c c !c 'c c c
  #c %%c &%c & c % c  % "c % c c 22'c c %c   c c
& c %&c c% %"c2'+cc
c
c

  c  
c 
cc
c
%  c c & c %&c 'c c  c c !c 'c c 'c c %c && c
c c %c &&+c c : 'c c c  c  c c  c 2c
c  c 'c c 70c " c +c
%c # /
 "c 'c c !c
% c c !c    c  c 'c %  c c %% +c % c
' c "c&ccc "c%c!"c%c' cc!"c%  cc%" c
 +c ('c '2'& c %c 'c 2"c c %c %:'" c >"#c %%c
 &c ccc& c%% c 'c c%  cc c+c c
 c&cc%% cc%c&cc! +c%c&'c& c
c : 'c c c %% #c %%c c c  c %c 'c %  c c
&c   c %c c 'c c 'c 2"c c & c 6, & c c +#c 5GGB9+c
 "#c . 2'c
 c 61#c  #c 
9c 'c :c "c ' 'c % c c
c
 5c c !&'c c 2c . c 'c c cc c &!c c +c c %c ! #c
&%c!' c c&'cc' c%c%c cc%c&+cc&c
cc
 5c c
 'c c 2c . c c c c c c c %c c c  c %c
%"' c'+c
c
c
à   c  c   c  c c  
c    c c   c  c  c
 c c c c ccc  cccc

 c cc


  c c   c  c c 


c  c c   

c  
 c  c



c     c mc  c  c c  c  c c  c c  c   
c


 c c  c 

  c   c c 

c  c     c c "& c #c %c


  c c c 'c !"c %c  c c (5+c c ' !c c c
(5c c&'cc%c%% c& c%"#c%cc: >'c%c c1#c c
c c %c & c ! +c %c  c  c ! 'c c c c '#c
 "#c   c c  c +c (c %c ! c c %c ' #c %c &%c
'c c 'c c :  'c %% c  > c % c &'c &c c
&%c  c%  cc c ! c +cc
c
%c' c 'c&ccc&'cc& c#cc !"c!"c4c 'c
 &#c %c &'c % c c c  'c %c c 2 c  c c :
#c  & 2c %% c ' #c c c :  'c
%% cc6
FJcF+c)9+c
Fcc2c% c&&c% c c!c
&'c #c !&c c c 'c #c c  c c  c :"c  & #c c  & c
  ccc%c:"c & c7F+c
c7Fcc)*c%c%c cc
 c c )*#c %c  c c c  c % c 'c %c %c c !c
  c 2"c 'cc  'c%c)*++c %& %c%ccc:"c
 & c c c  c &c c
Fc '& c & c #c %c ;&"c 'c
'!&c c %c c & c c &%c ! 'c  c c
F+c %c c c &%c
&'c !"c %c ' c % c %c  c c
Fc  c c "c c %c &c c
cc""c& c& c!'#c%%c% 2c!c 'cc&&c
& c c &' c   c  & #c c 'c & c 'c c
ccc6c !"cc. c'  9+c
c
c c !c :  'c %% c  c 'c    c
 c % c "c !c  'c & c ! !c c !! +c &c c 'c '2'& c
&& cc  c%% cc% c ccc
Fccc
+c%ccc&'ccS5)Mcc%c cc& cc 'c&#c%%c& c
% c c   c  c c 'c &c  "c !c  c  c c c 'c
&'  c   : c %% c %  +c  "#c %c  c c
%% cc&'c& &"c%cc% #c%%ccc c%c
c  !#c & c %% c c '&'#c c  & 2#c %% +c %c
&'c c%c & c!"c% c%c :  'ccc c c''c
c2&c&'c "c!c'c#cc &'c!"#c%c cc
F:c%% c
#c c%ccc%c cc% c&cc" cccc. c
'  c 'c  +c
c
2#c c c  c c c c 'c % c & c c Pc %& %c c c c "c
!&c c  c 'c   c  c Pc 'c c ;& c %c c %"  c
c % #c  %#c 'c % c c  'c  +c %c 2 c c %c 'c
' cc%c& c'cc% %c c cc!c&' '+c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
F &c 8c Tc   c  c 



c  
c  c 
c


c 


c 
c  c
 c 
c c Tc
% c c
 'c  c 69c 'c  c
 c6!9cc c  c" c
&&+c c "& c " c #c
#c   :"c c 6  c
'c  Ö  'c ! c . c
6. Jc  9c c'c!"cc
 c  & :7c 6
79:
  c c 6&c
9+c c ':"c " #c
% &c ! c c %c
% %"c 2c . c &c
 c  % c . c
c 6 9c '& c c '2+c
4 c c %c . c % c
5c
 &c c  !"c c %c
. c 'c  'c c  'c  c
 #c  'c %  c c
& c %&c 'c  &c
 7*c 69+c
c c . c
'  c 'c !%c  c 'c . c
&c c c %c
7:c
 c #c  & c c c c
 c c c 'c   :
"c c 6 c c  c c
  c '9+c c Tc
%  c c & c %&c c
%& c c c c 'c c
 'c  c 69c 'c  c  c 6!9+c & c c %c '#c   "c  !c
& c %% c &&' c c '"c  '#c   "c 2c &% +c "c c
ccc & 2c%% c 'c!&c2 c'c&2#c& c%% cr c+c
c &%K'c   c "'c 6 $
9#c c 'c c %c & c   c c  c c  'c c c
 'c c c c %% c 'c  c %  c c & c %&c % c c
 'c !"c   c ' & 5*#)C#)Gc 6 c  9+c
 c %  c % 2c !c !2'c '& c
 c  +c & c c  c  &c %c  c c 'c :  'c %% c c
6
F957+c
c
c

V.5.V.1c Changes in methylation patterns occur with age can affect by causing chromatin
remodeling

. c %" c c "  "c %c %c ' " c c c  +c
%" c c c "c 'cc%  cc%:' c +c %c
%c  c c "c c c 'c c %c  c c % c ' c
 c  c cc c  "c >'c c cc  c 'cc  'c
 % c%"6 % 'cc +#c700*#c1 '" '%" "cc +#c700*9+c "c2'c' 'c c
 c'%" ccc2! c&c%c  6<cc +#c5GCD9+c
c
c  "c 2c &#c c c !c % c %c c c '"c c   c
%" c c %c  "c &c c . c  +c
&%c c  c '%" c
'& c  c  "c '&c 'c  #c &%c c 45#c c  c c
 !"c c ' 'c  6c !29+c 45c  c  c c 2 c )*c 'c
 &c   c  +c :'c '%" c % c !c & 'c c !c c c c
  #c ! 'c c %c &c c c &'"c &  c % c 'c c . c %" c
 %c!&cc%c c !"ccc c&cc664 &cc +#c5GGD9c
+2'c% c&c%cccc %c&'"cc%%c2 'c& c c
c &'c c !%c %c ' &c + c 'c c   'c 2 c %"'c  c 6-9c
  c c &c !"c c c &>" &c c %c  3c . c %"  c
64& 9c +cc'cc%c' c& c c!%c+c%c 3c &cc
%c!2'c-'c c%cc! cc% cc  'c
!"c'& cc%c  c%c6%cc +#c5GGC9+c%c&c& c% c%ccc
%" c  "c &'c %c &c c c  !"+c %c  "c !c  "c
 cc :%c c #cc2c  c! +c
+c
c
%c cc&&ccc%c &cc%  cc%" c &cc'2'& c
c '& c  62 c c c +#c 5GG)9+c 2#c %c & c 2 c c %c %  c c
  "c &+c %c & c c 'c c  #c c %%c %"%" c % c !c
 'c%c%c cc c22'cc:"c & #c&:c2 #c. c
 #c #c 'c c    6F! c c +#c 70089+c %c   c c &%c %"%" c
2c c %c c  'c  'c c c c  +c %" c c c  'c c
 "c 'c%cc  c&+cc 'c c  "c&%" 'cc
 c c#c%c%  cc% c&&c& cc%"%" c&'c
2"cc +cc
c
c  cc% c7000cccc"%"c 'cc!#c'': '#c 'c
'"c #c %c &c  c % c 7Gc c 6 +c 5M9c %  'c %" c  &c %c
c7*c cc%"%" c 'cc cc%"%" +ccc%c%" c
%  c% 'c !c ''c +c  "#c %c  c c  'c 'c c c c
c%  'c%c cc%c&#c&  c% c%" c !"cc&:+c
 "#c c c c 'c 2 &c &c c  c c c %" c %  c c
!2'+c
c
%c c %c 2'c  c c %c  c '+c c c c &'"#c ! c 'c &:
c  c 'c !c ' c c c 'c c c %c 6F c
700)9+cc%c&'"#c22 cC0cc2 " cc cc*ccDBc" #c c2 "cc c
 #c &' c L:%c  2 #c  c c ):%""c #c
;&:c . c %" c 6!"c !&c c ;& 9#c 'c ! c %" c
 &c 6!"c 4
9#c c 'c c !'c c  c %c  &c c c c
6& c   "c 'c ;&  2c  :c $ 9+c %c &c ' c % c %c %c
>" c c c   "c ' &% !c  "c c #c c 'c c %"c  c c
%!c   !c 'c c 2 c c 'c c '!&c c ):%""c
. c 'c%c " #c  c%c :c+c
c
2'c c c   c c  c c c c c '& c  c % c !c
'c !"c &c &%#c %c %c  !"c c Lc  2 c 'c c  c %c
!2&c  cc&'"+cc%c&c c +c)0:'c : 'c cc2cc% c
% 'c: 2 'c%c c%c  ! " cc%c 2cLc%c% c!c
!2'+c %c  c !'c c c : 'c '&c c . c %" c 6< % #c c +#c
5GCD9c
c
:  'c c c  c c c L:'c c % c !c  ">'c
;&  2"c c %c c += c 2 &c &c c %c  c LK & c   c
&c'61:1 cc +#c700*9+c%c&c' 'c c c :c  cc
ccc%c'c &cccc&cc7+7Mc6%cc%c cc cc
%c  2c Lc  2c c c 2c c %9+ c %c  c ;&  2c
%' "#c %c ! #c 'c c c &c  c !&c c c %#c  c %c c
 c  ccc cc c'c c!"c&cc8+DM+c
c
c%& #c%c& c "c!c'+c''#cc c&'"cc%cL:'ci &ccB5c
c%>" &cc& c c%c&c6 & c4%K"% c"'9#c c c
>
%c cci  c c!! cc2c%c'c)0Mc6 c c;&cc 'c
Lc 2 9c cc&'6 c5GCC9+cF&%c&'c%'c% c%cc&c'cc
' !"c: 2 c &"cc&&#c!&c"cccc c%c): > :7:
'""'#c c c %!c c %" +c !c ' "c 'c % c : 'c
 2 cc ccL:'c c "c!c "cc% %cc&cc% cc%& c
c c cc%c&%c %c cc"cc :2'c2&c%:2'c  +c
#c%c&'c!c %c cc 'c c  c  "cc%& c
c 'cc+cc
c
(c %c %c % '#c c &'c !c c c %c %c 'c 4
c &c '  c
&!  "c c  c c ! c %" c  &c c %& c  'c %c +c

&c c c  "c % c c c %c  c #c ''c '  :c c ''c c ' c 'c
&+c. 'c cc'& c  c&'c!cc c%c%c: 'c
'"' c%"cc  c'c!"c % 'c&c6$%#c H#c
9+c ' cc
%c %"%c %c "c cc  c c %c :''c ' c  "cc cc
%cc cc' +c
c c&cc%c%"%c% 'c  '"c
!c! 'c cc%c ! "cc&c%cc%ccc 'c%"!'> cc
!c c!cc  c 'cc! c 'c2cc'c2&c"& c+c%c c
c!c%c cc$ #c 'c2c!c%c cc%:!c  "+ccc
c
c
V.5.V.2c Chromatin remodeling is also side effect of DNA damage repair mechanisms
c" #c. c'  c'&c c cc% c'&c%% c 'c c c
+c c %cc &c% c"c 'c% :' c>"cc%c
. : c c c " c 'c %c c c  +c . c '&!: 'c ! c
6.
19c c22c%c&cc%c'cc%c c#c %c%c%c
 c c c &%c c ,&D0AC0c 'c . c  c +c .
1c  c %c . :
'  cc c #c  cc. :$,#c%%c%%" c%c&&' c%c
7 c 'c 7 Lcc" c 'c  #c2"+cc
c
%cc c %c ' c  c  %c c  :! #c  "c  c %c c
 & c c 2 c +c c " #c % :' c  c % c c 22'c c . c
 #c&%c c%c "  c6 9c 'c%c' " c6 . 9c cc c
%c %"  #c c %c &'c c %c ! c +c %& %c %c c c c
%c% :' cc'& c. c ccc&"c&''#ccc&'c
% c%"c' c%c"cc c 'c  c%c cc!"c%   c%c% c
c &'c %c c c '  +c c " #c c 6&%c c  59c 'c . c 6c
 & c
*#c '*c 'c %c &c 59c c  c c % c ' c c % c
c c''c 'c'" c cc%c' c2c%c:&cc
.
1c +c
c
c "#c %c c c c  >'c . : c >"c !&#c  %#c % :
'" c >"c % c % 2c 2 c &c &'c . c  #c &' c c  +c
&c c &%c  c c c c '  c  "c %c !c  'c !"c c c c
&c c %c   c #c c c %c  c c %c
c +c %& %c c c c %c
' " c '& c . c  c % c c !c ' 'c c    c #c %c c
&&  c2'cc% c' c!'c 7 Lc%%" +cFc #c
%c%" c% c!c'"c'cc%c&cc. : c cc%& c
+c
 "#c %" c c 4"DGc c %c *c &c %c )*:!' c :5c
6)*1$59+c &cc%c cc%& %cc%c%c. : ccc%ccc
'  +c  "#c %c % c  c c !c 2& "c 2'c !c " c
'c   c ! &c %cc " c)*1$5c% &c !7c c c &'c c .
1#c c
c% c;&c%" cc4"70cc B+c%c c% c)*1$5c c c!c&'cc%c
. :'  :  'c%% ccc 'c"c!! c&%c! c
%c ' c % c %c 'c  "c % 2c c & c c '& c %c . :'  c c c
  c 'c c  'c . c '  c c c '&c c ! c %  c c % c
%&+c
c
%c cc c%% cc &'ccc. c'  c "c c%c
. c'  c %c'"c' c c+cc%c%c#c "cc%c
:c%  c% c c!2'cc 'c'2'& c&cc c% c %#c c
'cc. c'  +ccc c2 !c% c c c c cccc
'  c% c%#c%%c&'c ccc%c' !#c & 'c%  c% c c
!2'c !c 'c '2'& c c %c  c +c ''#c . c ! c &c c
"c c  c &% #c 2c  c c %c +c F&%#c c c c
%c % c c c c !  c c c '&'c c   +c c c !c
 cc2 c%%c%ccc c. c'  c c%cc% c
!c' & 'c%c +c
c
c %& %ccc2 !c%c. c'  c %c 'cc c#cccc!2&c
%c : 'c c 'c . c '  c &'c &c c c 2 +c %c ;&c c
 & "c  c c ''c ! &c %c  c c c % c c   "c &:
 & 'c %c c & %"c ;& c c 2c 'c %c  c % c c ': & '+c
2#c c2c2 c  cc!c 'cc'c  +c(c  c "c
!c % c . c '  c c %c %c c c   c #c  ' c
'"c c c '&c c c c   c +c 2#c %c '2"c c c % c %c
 'cc%c c' c% c%cc "c c!c c+cc
c
? c !  c %"%=c 'c #c : 'c :c %  c c
  cc%c'!&cc% c'ccc c&cc %+c
%c'c c c%c' c% c. c'  c' c% c' c 'c
%  cc& c %&c% c&c2c c#c%%cc%c2'c% c' 2c
c 'c. c'  c c  c%c  c+c1 'cc%c!2 cc"c
'c &7C#ccc &!c% c% c' c'& c. c c c2c&"c
'c c %c :'  'c  #c & c c  2c  c c !%c % :
' c c 'c c7C+c
c
%c ;&c c %c '!&c c % c '" c >"c &'c !c '+c
$2&"c c  c  "c !c   "c 2#c  ' c c c c
c '#c !"#c ' !> c c 2&"c %% c 2c . +c 1"c
 #c c  "c !c 'c  c c c . c '  c %& %c ' c
c% c c cc%c cc
F+c ' cc%c'#c& c&&c
'c  > c c  2"c 'c  !"c 'c 2c #c & c c %c & c
'ccc 'c&+c%c'ccc%c!%c%c% c%  cc c
c c '!'c !"c 3 c 'c  &BGc 'c %c '&!c &c c
  c %  c % c &c c  c #c %%c c !c ' 'c !"c %c   c
%&cc c 2c&+c
c
2#c  c  &c 'c   c '& c 'c c . c   +c c
'& c%cc "c!c2 !#c cc%c. :;&c& c% c&c c
%c  c c % c '  c c . +c 2#c c c c !c % c & c c
;&c c . :;&c %  +c
c %c  c &&c c . c c &'c
;&:''#c & c  c !c 'c c &c %c % #c %!"c  & c
: c%  +c%c cc&cc. c'  #c%%c% c!c' 'c
c  &c %  c c &c 6 c+c +#c 5GGD9+c . c %" c 'c . K
%c 'c. K:%cc c %c c%& %cc >c%c c
c   "c 2c 'c  2c >+c . c '  c 'c & c  c '&!c %c
 cc & #c%!"c & c "c'c cc!c'c 'c2c2 +c
c c %c !c % c : 'c %  c c . c %" c  c 'c %c
c%  c c' "c %c% c "c2cc%c  c+c
c
2#c %c '&c 'c &c ! c c %c  c c c  'c c . c  c  c
c 'c  &c %" c  c %  #c . c  c c '"c % c 'c  &c
& cc!"c 2 cc)*cc "c &c c  cc 'cc
 c 2 ccc 'c &c&c'"&+cc
c
c

" c c
c
  cc
-
cc ccc
- -c
c
 c
  cc c cc c 
c c  c
c
c

" c c c c

 c%c'cc ccc&c cc'c2c%c&c2c 'c%c "c2c6F +9+c c


%c&c2#c%c c % "c22'c&'c%c'c&AF:5c % "c6.2 cc +c700D9c 'c
%c &:2c  c   c c   "c 6( 9#c "c $:''c  c 6$, 9#c 'c
%GA ,+c
Fc%c c '#c%cc c& c2c'& c c c c' cc%c cc . A .ƒc
'c $A .$+c %c ' 2c 'c %": c  c c %c c c !2'c c  c c c %& %c %c
2 c c 'c  % "#c %c !c c c %%c 22c%c  .ƒ:''c ' " c  'c
&c
'c%c $:''c c6 $,9+c%c c22'c'ccc''"c6F +c89+cc #c cc
% c#c%"ccc" >cc:& c%c & cc& c+c
c
c
c
c
c
c
c
c
c
c
F c Dc  c  % "c  'c
%c c c  +c  !c
&& c  c%& %c c&c
'c "c2+c c' c
c%c&c2c': & c
%c 
c  % "c 'c %c &:
''c  c ( #c $, #c 'c
,#c %%c c &c &: & c
c c  >c &%c c
%c  c  c F:1c 'c
F(L(+c c   #c %c =c
 c !  c '&'c !"c
 c & & c %c  .ƒ:
''c "cc
&c 'c%c
&:''c  c $,#c
%%c c&c 2 c 'c '& c
%c c +c
&c c
c22'cc%c 2 cc%c
4,15c +c(2 #c cc%cc%c!c cc%c &#c&22 c 'cc c cc 2 'c%& %c%c 2 c
c2 cc6c!&9c 'c%!cc%c6c 9+cc
c

" c c c 


c
  cc
%c2'c& c% c%c!  ccc c c"c 'cc% c&+cc #c 2c%c
  c!c  c 'ccc% c "#ccc%c'cc  c%c' " ccc c
c  cc! 'cc 'c c !"c6F +Dcc "' cc +c700D9+c%c% c!c%c "cc" c
%#c
&c
7c% c!c'cc  cc%& %c%c'& cc% c&&c6& cc +#c
70009+c %c ;&c c  c c % c % "c% 2c !c 'c c  c c %c :c
c'&'c!"c (
cc% c'& c' 2c+c<%c%cc  "c&#ccc! c  "c
 c% c (
c cc%c"c' cc%c+c
c
c&c'  c& c% c c c cc%c cccc c&'c!c'c%& %c c :c 2 cc
2c %"c&'c:"c c 6+ +#c 2 cc '" c %"#c c "c  #c
. c #c 'c%!cc c 'c9c6 cc +#c700)9+c%c&'c c c %c 'cc
c ! c c c %c +c %c %"#c c c %c c %"#c  c 'c !"c  c c 5GGCc
6 cc +#c5GGC9#c 'cc&"c&'c&'"c6 cc +#c700)9+c%c2'c& c% ccc
 c 22 c % c c 'c'  c & c '  cc %  c c !c%& %c%c c c
c #c 'c  c %c c c c  "c 'c % c &&c 6F +c 89+c %c c
&c c "c c %c &&c !&c c c %' c . +c  c '&c  3c %  c c c c
 #c %%c c   c c  "c % %"c &:c 6F&c c +c 70089+c %c c   'c  c !c
 'c  "c c%c' cc22'ccc
659c !c % "#cc
679c
c#cc
6*9c. c'  c #c
6B9c% c&&c & #c
6)9c. #c 'cc
689c%' : 'c+cc
c
%c % c % c' c %c %  c &'c'& c c%c 2"c c  c "c  c c
% c & c cccc c6+ +#cF(L(c c 9c6& c 'c$ 'cc +#c700)9+c cc
c%c ccc c 2 #c%%ccc&c2 cc'c% c & cc'2'& c
c !"c'& c c c c #c 'c %% > c c  c  c c%c c % c
 %c&'c "c #c c% c!c!2'cc%c cc& c. c%c%c( c%!cc" c

7c 2 c6& cc +#c7000Jc  cc +#c 'cH% cc +#c700D9+c%cc "c&c%& %c%  c
c . :!' c "#c >" c 2"#c c & c  > c c "c  c  c &%c c :
2c  c  #c c 2 c &c c  c  %"c 6+ +#c %c ' " c - . /c c
%"  9+c2c
 cc 
 c c

c 
c c 

 c c c
c c

c cc 1-
 c
c c 0((E3c %c cc "c  'c c % c '!'c !2#c c  c c %c
 %"c22'cc cc''cc  c c +c%cc&c2 cc
c c % +c %c c  c 2 c c . c  c 6 !c c +c 700*9#c (
c ' c
 %"c6L cc +c5GG)9#c 'c 'c'"cc. c c6
2  2 cc +c5GG*9+c%c'cc
'c'& cc% c&&#c%%c% c2ccc. c! #c. c #c 'cc
"c #c  c%cc6 ;&cc +#c700G9+c
c
 c  c & c  c c ' 2c
c !"c '& c %c && c c !%c
& c 'c %' c . c '  c
'&'c !"c (
c 6F +c D9+c 2#c %c
2c c . c c c  %c c
 c c c ;&2 c  c
'c &c 6
& c c +c 700B9+c  c
 c . c  c 2"c 'c
2c %c ' 'c 2c c &%c
2"c!2'cc 'cc6 "' cc
+c 700D9+c %c . c  c  % "c &:
 & 'c !"c  c c %c %c  c
% c22 c. #c c6&c
c +c5GGC9#c1 c6 !cc +c700*9#c
:
% :''c  %c  c 6 c
c +c 70079#c 'c %cc c c
c .
1c  #c   c 6c c +c 700*9+c
 "#c  c c "c  c
c c %c . c  c  %"c
6 "' c c +c 700D9#c !&c c c
%c 2"c 'c'"cc c>"c
&%c c . c " c c 'c !c
6 !c c +c 700*9+c %c c c  c
c   c c &:#c ! c c
&'cc'"c 'c& #c!&cc
2'c c c c 2+c %c c
c c &c 2 c 'c 2c c %c
  c '& c c ,&D0AC8c 6c
c +c700*9c
c
F &cC+c ccc% +c c% c cccc% c c%c'c2P% c&&#c cc
6&: & c c  c c 'c ': & c c %c c ' 'c !"c %c 9#c 'c . c  P%%c c  c
'&c c cc c !"c 'c c #c c c  "#c%cc c ccc cc
c
c
c

2 c &c c  c % 2c !c & 'c c ! c ' c c %c  c c c % +c %c
 '' c%c%c!c' cc&%c cc c%c
7c .ƒ:''c' " cc c
&c% c
% 2c  'c "c c  3c  "c c    c c % c '& c c c  c 6& c 'c $ 'c
700)Jc
&'c 'c'c700DJc ;&cc +c700D!9+c %c c cc% cc( +cc ''ccc
   c  % "#c ( c   c '"c c%c  & c c & c % +c '' "#c 2c %c  c
 %c!c c 'c%c .ƒA . c2#ccc"c% c%c% c 'c c%c 2"cc
 "c&'c!"c%c'c cc%cc %c!c22'cc c+c
c
c

" c  
c

c  c   
c c c c
c  c

  c c

c
c c
c
ù c c c
 c c    c
cc
c  c c 
 c 
   c c  c
c
 cc  c c

 c c  c c   c   c  
c

 cc c  c
  c cc
cc c  c
c  c      c  c c

c
c 
c 
 c cccc   c    c
c

c
  c
 c
c  c c   c
  c
c c c
 c
cc cc

 c   c
 c  c  c   cc   c c c  c c 
c  c
c
 c  cc
 c  c c   ccc  ccc !c
c c!"  c
 c  c c# 
c $c% c &c' c &cc# 
c (c)*+cc    c  c 
 c
  c

cr, c $cc
ccc
   c
 c c
 c c
c 
  
cr- c
 (cc
c
 c c


 c
c c cÔ c  crÔ   c
 c c +ccÔc cc. cc
c***+c  c c   c
c&/c c 
  c c  
c
c'  c  c&/c  
c
   c c

 cc  
c  
c
c &/c c 
 c
c
c01#c  cc
   c
 c
c ccc c!"  c cc +cc cc &/   c c
  c
   c
 c
 c  c  c

c
c&/c   c c  ccc
c
c

 c %pc ccc c


 
c 
c
c
c
 cc c 3c : 'c' cc#c%& c 'c "c%c  c61 '&cc +#c700)9+cc
%c !cc #c  cc"c%  >'c!"c&c %"c 'c'  c6c c +#c
70079+cc   c&c c!c'!'c c! c'ccc 3c& cc
c c  c #c %%c c !c c   2c   "c c  c c 3&"#c 'c
' 'c c#c!cc '&ccc&c 'c >'c&A c&+c
1 'cc%c  #cc 3c% c c &cc&c'  c  'c%c
c c c c c c '2c  c 6c c   2c   "9c 'c c c ' 'c
 c c &#c %%c '"c  'c c c c  c &+c 4c c ' 'c  c c
&c  c '' "c '"c c '&c c 'c  c c !"c  c %c &c
2c% cc cccc&c6%ccc%9+cc  #ccccc
c'2c c c&c%& %c&c% c&' ccc#c' %cc
'"&c c %c %+c (c c % c % c  c &c c %c c c !%c c c 'c
' 'c cc&cc%c  '& c && ccc. c'  +c
c
$c. c'  c 'cc&c&c&'cc'"&c6
'2 c c +#c 700B#c
! cc +#c7008#c "   cc +#c700D9c 'c c& c63 cc +#c70079#c!%cc%%c c%c Jc
!%c c % 2c !c 'c c !&c c %c c c c 'c ' 'c  c c&c
%c c 61 % c c +#c 7008#c  c c +#c 700Dc 9+c . c '  c && c c c c % c !c
''ccc 'c "c!&cc%c cccc'2c c'& c  c6 cc
+#700D9+c%&#ccc"c% c. c'  c!&cc  c!"c ccc'2c c 'c
!"c c  c %c  c&c &#c &' c c c %+c )*c    c c % c
ccc%c. cc%c 2 cc. c'  c%#c%%cc&c 2 ccc
 cc c'cc &ccccc+cc
c
' c c
-
c c 
cc  c cc c c cc
c

c%c!  cc%c cc% 2c!c'& c%c2 &c % "c% c "c!c
22'cc  c! cc. c'  c 'cc c 'c "c2 cc)*cc
& c'c%& %c  c+cccc%ccc%c2 &c
%"c% c%c&c c2cc c 'c c'2 +c1ccc2c!"c%c
 cc cc c)*cc 2 'c 'c%cc "c'&c%c&'cc% 2c2'cc
%c c%c2 &c'cc)*c& +cc

c
2 c c )*c %& %c %c . c .  c  c 6.. 9c && "c  'c c %c c  c c %c
c c  c c %c '  'c c c %c  2c c +c c  c &c %c
% c!cc2c %  cccc 'c%c'cc c c% @c%cc
&'c!c c  c #c! 'ccc cc'c2'c 'cc c c% %"c
''cc%c#c&c 'c%"  c+c(c cc% c!c'  'c 'c%c.. c 'c
)*c c 2 'c 6F &c C9#c c c    c c c  'c c &c c c  :c c  c
'+c c  c    c #c %c c &c &%c +c c c  #c  c  c c %c
. cc! c' "#c%c 2 ccc"c%c!"c ,5#c ,7c 'c)*c 'c
c cc %c c61 cc +#c700B9+c<%c c cc%cc&#c)*c
%" "c >cccc. c'  ccc c6 c %'cc +#c700)9c 'c& &"c
& c %c c c 'c c c %c c %c c 6+ +c%c ":''c  c
%!c759c cc cc;&'ccc. c cccc% c;&c c
 c6+ +c ..B)9c6&&ccc +#5GG)9+c
c
(c %c  "c c c c  #c %c c 2 c  c & c &#c c c %%c c
% 2"c&'c!"c%cc"c cc c%c2"cc%c. cc6F &cC9+cc
c
69c m c cc c "c%c. c'  ccc2Jccc%cc%c
&c c c  c c %c c 'c 2"c c %c '  'c c %c #c c "#c
;&+c  "c %c & c &c c %%c )*c c  c c 'c
 #ccc 2 !cc%cc 'c +c
c
69c #   c "c  2"#c%c c c "c +cc%cc&22c 'c'cc
c %c  "c 6c c 'c *c 'c Bc !9#c %c &c  c !c & #c
&' c% c ! +c%c #cc%c'2cc +c
c
69c $"c %c %c '  c c 2"c 2#c )*c   "c & & c c c
c &%c c c c %c 1 *:"c  "c 6$ #c (L c 'c 1 L9#c 'c
' & ccc c&%c c14:7c 'c
 c6(cc +#c700*9+c"c
'c 1 *:"c c   c c %c %' c 'c c c c
  'c   c c %c %' c! c 6.  c c +#c 700B9+c 2#c )*c c  c
  c c %c %' c 'c c %c %' c c   'c !"c
 c'"c%c : c14:7c "c!c6&%"c c +#c 700B9+c cc
c c% cc  c&& "cc'& c!"c'2#c
'c c c &c &c % c c   c 'c '&c  +c 1 &c
c 2!"c 2c c c &#c %c c  c 'c  c c 'c
&cccc cc 'c!&cc c'  c6.  cc +#c700B9+c
c
629c ë


c    "c& c&c c. c'  c c% %"c''ccc
"c 'c %"  c c 6.  c c +#c 700B9+c <%c "%'c  c && "c &' c
c  c 2c . c '  c 64c c +#c 5GG*9#c  c 'c c % c
 c &' c c 6.c 4 'c 5GGB9+c
c c c c c
  c 'c c  c c  c 'c % c  !%c  c c %c +c %c
c c c  &c '  c  c c & c  !c &' c %c
c c c % c  c'"c %c &c 2c 6 c c +#c 700)9+c c
c c "#c 2 c c )*c c & c c   c %c c c  c
. c '  +c c c #c )*c c c  c c    c %c c %c
+c c %#c )*c c ;&'c "c c  !%c %c c %c #c %%c
&!;&"c !c 2!c 'c )*:''c 61 &3&c c +#c 700*9+c
c
c% 2c!c%cc && c%c cc22c6,%cc +#c700B#ccc +#c700*#c
.c c +#c 5GG)9+c1 &c %"c % 2cc %c !"c c  #c c c  c c
 c   c c &c  c 'c  Jc %&#c c  c 'c !%c c
6<  c c +#c 7008#c >c c +#c 7008#c "c c +#c 70089c 'c  c 6 ! c c +#c
7008#c "   c c +#c 700D9c c +c 2#c ! &c c c #c %"c
% 2c %c !"c c c %c &c 2#c 'c  c %c c c %c
'  cc c 'c cc%c6 c c +#c 700D# cc +#c700)9+cF "#c
c c c  c &%c c  c   :*c 6$:*9#c %%c  2c
 :& c  c ' #c c 'c c % c c ' c 'c
& c cc %c6 c700)#c$ c700)#c4&c700D9+c
c
c
%c&c& c&c 'c%c c cc&c% c c& >'ccF &c
Cc 'c c c% 'c!"c%c)*c   c+c%cccc'&!c% c 2 cc&c
&c % c &%c c c 'c c &c %c '2c c  c 'c
%c c  2"+c c  #c c c )*c  'c c c '  c '&c c . c '  :
'&'cc c'c64cc +#c5GG*#c &"cc +#c5GG*#c4cc +#c5GG*#c%%&cc +#c
700)#c %%&c c +#c 7008#c , 2 c c +#c 700B9c 'c %c 'c %c c  c cc 'c
%& c'&cc "c c'2+cc %cc%c& c&c'c !2#c%c cc
%c c  "c &''+c .c c )*:''c c  c 'c &%c c c 'c
c  c c %c &22 c c c %c  "c 2c c '  #c  ' c c
2c& c && c 'c c  +c
c
<%c c c  c % c '&'c )*c 2"c %c c  c !"c  c  #c %c 'c !2c
  ' "c'c% ccc)*c%&'c c2c cc c'c&%c c c
'c c % c c &c 'c  c '  +c 2#c c )*c 'c c &c
'  c  'c%c  #c 'c)*c 2"c%&'cc  c%"c&%c 'c
'c c 'c c '&'c 'c c  +c
c c %c !c  c 'c % 2c !c 'c c
+c
c

c
F &cC+c%c cc)*:' 'cc c'cc&c% c 'c  c 2"cc%ccc2c
. c'  #cc 'c!"c)*c &c cc %c #c cc#c%%cc&cc&c
%"c 'c  c  +cc #ccc)*c&c2c cc c'c 'c'   "c 2c +c
c
c

l c %

cc
c

c % 'c !c c  c 'c % c c  !"c  'c c  c %"+c 2c
%c % 'c  "c!c  c c c 2 c "c c %"cc  +c %& %c !2c
2cc% 2c'cccccc%c c+cc

cc;&c!2&c% c "c cc ccccc  cc  cc


 'c %c c  c  c +c . c '  c c '&c c 2 &c ' &c 'c
 &cc c%c  ccc% cc  +c 2c%ccc2'c
c&cc "c2c &c && ccc c%c c% c c  "c
 cc&c+c%c c "c% c% c% 2c22'cc&c c c2c
 c & %cc '&c  &c cc c c c  c 'c %c%c c
c2'c 'cc!c%%'c2c!c%"c c &c '2c+cccc! 'c
  "cc c'2'c%c% c c  c 'c +cc

%c ?  c =cc  "c2c . c'  c 'c c  !"c 6 c c +#c
700*9+c %c #c %%c &'c c 22'c c . c  c  % "#c  "c   c
% %c 'c % c  2"c !"c   c %c  !"c c %c #c '& c %c c c
 c 'c  c  c 61&c c +#c 70009+c c  #c '"c c %c c
 &c c&!cc 'c"'#c&' c<#c %&'K%#c "c
'c%%'"%"+c%c c;&"c% 2c c 'c'cc c 'c
%!c  c  &c c  &c  +c %c ? c =#c %%c &'c c
!c c c ' %c 'c c "c #c &'c %c  c &&c &c
6 c c c +#c 700*9+c %c  %c !c %c c #c &&c
&c 'c %c  c c c c  c % c c %c  c c c 22'c c . c
 c 'c  c+6 "cc +#c700*9cc
c
 c ' c &c &c % c 'c c ;&"c  2 'c !"c
& cc c cc c2 "cc +c & c 'cc% c "c c
c & c c c c c c &c &c % 2c c  'c &!"c c  +c

ccc c"cc c&c&c'cc #c c cc"c&!c


c c %c 2"c c c &&c &c  %c !c 'c c !c c c &c
'2+c %& %c c  c c &c &c 2"c  c '%c %c c c
'2 c #cc% c!c'c% cc "c& &"c  c : 'cc
c &c & "+c %  c &c &c &c &'c c  c c
c#c% c cc c#c%!"c'2 c%c  c+c)*c
c c c&c&c% cc& 'cc%c 3"cc%& c +c)*c&c!"c
%  c& c cccc c2 "cc& c#c&' c. c'  #c
%" c 'c 2 'c +c)*c2"cc%c cc'  'cc 'c
%c c c    "+c
c c   c &c c    c
' c c )*c 'c %c '&c 2 c c 'c   c   c 'c
&c c%c +c )*c 2 c  c 2"c %!c & c  c !"c '& c c
"c #c cc+cc ''#c c2 "cc 2c 'c2c'! c
c c 2 'c %%c & c %c   c  '&c  % "#c '&  c %c )*c
+c%&#c ccc % "c2 c&c)*cc %"c & cc 2"c6 c
c +#c700)9+c
c
%c c &c 2'c % c c  % "c c   c c . c  #c  "#c  #c
c  c 'c .
1c  #c !c c c %c c  ' c c && c c
& +c&%cccc !&c%c &cc%c' +c
2 c&'cc&c
: 'c' cccc. c c>"cc%c 2+c<%"c'c2cc
. c  c >"c 'c %c #c 'c %"c c %c c . c  c "c '@c

c. c c 'c. c'  cc c %"c'cccc cc


& c % c . c '  c c !c c c c % c ' & 'c %c
+c 4c c . c  c c  &c   c %  c %& %c & c %c c
c 'c c 'c !"c 2  c c )*c ' 'c c  % "+c 2c !"'c
. c '  c #c c c c  c c % c 'c  c !c c 2c c
#c%ccc "c!c '+c "c cc c 'c!c%c
c c 'c !"c . c '  c 'c &AF5c    +c c c    c
!c ' & 'c %c c c  "c c &c c . c  +c .c %c !2'c %  c c
. c c 2c%c c!&cc%ccc  @cc "c!c'&ccc &K
c  %c c %c &'c c  c  #c %2#c &c &c &'c  c
2'c +c .c c . c   c  "c  'c c  'c  +c  !c
 c cc'cc  ccc'cc +cc% cc!c'c% cc
c . c  c & c %c  'c %"#c 'c c  c % c "c & c c
 & c % "c c +c 2#c cc &c  c"'c c &'c
!"c & c c . c  c c c c   !c c &c %c % c  c  c c
 &'#cc c!"c%c'cc. c c  "+c

%c 2 c ;&c c 2c  c !c c c  '& "c  c %c &c c c
22'cccc 'c. c +c. c c!ccc 'cc:
c  ' c c   ' c && c c . c '  c 'c & #c %%c &%c
 ! c : 'c %"  c '+c && c c & c  "c !&c c
 c!"c  c c c 'c'&! c c +cc ''#c& 'c
. c'  c "c!&cc  c!"c  c +c c%cc%c!  c!c
c' %c 'cc c "c 'cc% &cc%ccc#ccc&c& "c
'c& c'+c  'c  c'&cccccc% c!c!2'ccc
%c 2 2c )*+c c %c & 'c . c " c c   c %c  ' c 2"c
%!c  'c  c '&c c  'c #c 'c   !"c 2 c  c & c
&' c &c  c'&cc 'c #c%%ccc  'c%c c c
c & c ;&"+c F&%#c . c '  c 'c & c  "c &!c % c
&&c 'c &c c%  +c

c c 'c %c ;&c % c c  c c c c c  % "c 22'c c c
  #c c  'c '& c c   c 'c +c %c  "c c
 !"cc 'cc2 &c&c 'c c%&'c% 2c'2"+c% cc& c
%&'c!c&c+c%c%&'c!c'c cc!2'c c  cc
'c  +c (c  c c &%c c &c c % c 2 &c  c 'c c c
 2c 2"c c c 'c ;&c c  c )*c %c %&'c % 2c
&'c   c %  c '&c c 2 &c  c &%c ;&c %  c 'c
& +c %c &'c c  c % c . c  c % c c c !c 'c
'"c c c c 'c c +c (c "c  "c &c % c %c c  &c 'c
"cc& c 'c c  cc'c cc && +cc
c
c ccc c% c c cc"c &+c''cc&c c% c& c
;&"c ''c c 'c  +c <%c 2#c ! ''#c #c 'c &#c  c
c%'c% %c cc& c;&"c%c #c cc& c;&"c
c! c c  !+c1&c%2#ccc 'c% ccc &cc! c! c ccc
 +c 1&c % c %c c c %c c 'c c 2c +c 'c &c c  c c
& c ;&"c % 2c !c !2'c c % #c c c c  c  c +c #c
c''cc%c "c 'c cc& c;&"#ccc c c"c 2c
2"c cc& %cc c cc& c;&+cc
c
cc 'cc%c "c'cc& c c%c'c @c%c cc
% c "+c Fc + +c %c % c 'c 2c %'c !%c c & c 'c c
   c& cc ccc"cc& +c& c c c
 c c"& c c%cc'2 'c "c%c cc'c +cc! c 'c
% c% %c;&"cccc c c& c ccc c' +c%c 'c%c
&c&%cc c% c%cc''c c'cc& c c%c'c"c
cc#c 'cc''cc;&c#cc#ccc 'cc+c4 #cc c
c%c% c2c c c2  ccc& c 6c !29c
cc
" c%  c  cc && cc c2"cc"#c!&c  cc&%c
% %ccccc "c &'"+cFc+ +cc %" ccc2c%%c
c c ;&c  c %'c D)Mc % c ! c c 'c c c c  'c c
50Mcc"& c +cc%c2 c& cc&cc%& c! c*:BMcc&'cc!c
&'c%c"c0+8Mcc c"%"cc &'+cc

"c c ;&c  c % c c %c %c c c c  !c 'c % c "c c
 !c 'c &c 'c c %"c c c c  "c  'c c & c 'c %c !"c )*c
2 cc c cc  c+ccFcc'cc &c&cc && c
c " c %  c  c  'c c '2c c c  +c 2#c c 'c !2c
" c  c "c && 'c c c 2 c c )*c ' 'c c "c
+cc c!2&c% c%c cc "c!&c' "c &cc c 'c%"+cc
ccc% c &'"c ccc%>" "c%%c&'c 'cc& c'+cccc




!c c  c 24c 
c %c c  c  c '"c c c c c c
c% cc% cc &c 2c+c 2c'&!cc' c
c c c &cc  c  c c'&cc ccc&c +ccc% c
 c c !c ''c c c  "c  &c %c &c %&'c &c 2c %& c %%c c c
!&'c c !c c  +c 2#c c &c &c 'c %c 'c c  c >"c
c  'c c  &c  c %"c c c 'c '" c   #c %%c
% c cc &c  #cc%& c6 cc +#c700)9+c."& cc c
 >'c !"c %c . c  c  %"c c . :.
1c 'c %&c 2 c %c .. c 'c )*c
6 'c c +#c 700)#c '= '' c c +#c 700*#c 2c H c c +#c 700)9+c c 'c c %c
 c   "c &!&c 69c 6 :A:c 9c ccccc c c&#c
'c  c  c  c % 2c c ' 'c c  c 'c %c ' 'c !'"c  %#c
 'c c c 'c ' "'c &'c %  c 61 c c +#c 5GGD#c &'%c 5GGG9+c
1 &c c % 2c  c #c  "c  c  :A:c c c %" "c  c
'c% 2c c cc +c "#ccc%c &c  c%"c!2'cc
 c  c :A:cc&'c!c&'c!"c)*c'"+c%c&c' c% #c c
 c c c :'c !  &'#c %c c 2 c)*#c %%c !&c c
 &c  c6%cc +#c5GGG9+cc

 c & c  c c %c c %c c c  c c  !"c c . c
& +c 1 c c %c c &c 'c c (
c . c c %c c c & +c
& cc%' c cc 'cc'&'c"ccc c>"c
 ' c c  c '&c c (
#c %c c '"c c c % c c %c & c
c 'c & c . +c (
c  &c  'c % c c c . c 'c
%c'"cc'"c "c 2 c)*+cc c % c. c& c &c "c
% c'"c"cc%c cc& 'c. c'c c c%%'c2+c%c
& c c &' c  "c  'c c   c 'c %c 2c c  c 'c
& 'c . c  c 2 "c ' !"c !c c c %c  c &+c c %& c  #c
  c c  c . c & c  'c c  c  "c % c '"c c c
2 "c c &#c &%c c ! #c % c 'c  c &+c c  c  c c & c
  c %c  c  "c % c '"c c c c  c %c %' c
' c "'c  &'c !"c %'c  % c . c & +c c .&&c c +#c 6700C9c
 "c '''c %c c c  c  "c % c '"c c  c 'c
%' c' cc&c%c c&cc c 'c "c% :'c&c
c ! c c 'c 'c % c c c c 6S70M9c c  "c % :'c
&c c %c ! c c &c c  &c "#c % c  &c ' %c c %c
 c&c"cc%ccc% %c6S80:C0M9+cc%"c c%'c% c "c% :
'c &c '&c ' %c c  c &c !"c c  :& c '  c
% +c%c&'c 'c%c'&'c!c%c% c. c'  c c c &c
c  c&'cc!c2'+c 2c"c c%c % "c2 cc)*c' 'c
c 'c& c#c%2c%c cc'&!c ' c2&c"+cc

%c c "c c c  !"c %%c &'c %c c  c  c %2c
%c c"cc2'ccc&+c1&c%c2'c ' c%  cc%" c
 c !"cc45c c%&'cc!c&' 'c cc c &c c
 !"c 'c c c c c '"c 2 c )*+c %c c   c 2'c c
 c !"cc c 'c&'  2c' +cc

F "#cc;&'c%c& c c!&cccc  +c 'cc"c&cc


 cc'cc%c #ccc%cc&&ccc  c %+c%c"c! c
c %& c   c   c &%c c<
c 'c $
+c<
c&c '&c c 'c c Rc
% #c %c $
c c %  >'c !"c & c c 4 c c %%c 'c 4 c c
+c & 'c 4 c c 2  c c c &'c c  c  c 'c %c  +cc
& 'c4 c c &ccc%% c%c& !cc'c 'c c%c
' c  +c %c c  &c 2 cc )*c !"c%c 'c &cc c
%% cc!"c%  cc%" c c c45c +c
'"#c%c
' cc%% c  'c c  'c   c c c %c +c c c
%c  c  cc c #c%c  c%"cc &'c!"c& cc c
c%%cc!cc'cc. c.
1c 'c  c  c c % "+c c
&c $c , c %%c   c c  !"c !"c '  c  c !c
c . c 'c& c  +c & 'c c c  'c c c && c c .
1c 'c
& !cccc'c!%c!cc 2 cc)*+cc

&c %%c c 2 'c '& c  c c %c %% +c c "c . c ! c c
''ccccc cc c >'cc. c! c%cc &c
% c' cc  c. c +cc%c c &c%c2&ccccc
. c'  c c+c
 5cc!&'ccc. c 'c  c"ccc&'cc' c
%c +cc

2#c c c c &' c )*c ' 'c c c  c $c &%c c
  c %%c '  'c %c  & c  c 'c  'c c &c '"&c c c c
c  c !"c   c % c c    "+c c  c &'c % c &%c c  c c
  c 2"c c ' 'c c c &c c % c ' c c )*c ' 'c
c % 2c !c  '+c c "& c c (5c c &'c c %% c !& c
%"c  >'c %c 4 c 1+c <%#c c 'c c c %c (5c  > c c
% !'c !"c c c
F+c
Fc c c c !c  'c %c %!cc 7F#c
%%c c  &c 'c %%c c c c %2c & c c +c 1&c
Fc  &c
' > cc(5c c c ccc  c c 'c%cc &c
2 cc  +c%cccc;&c c% c%"c 2 cc)*c 'c c
c&!cc&%c c c %c c&!cc  c c c  c  &c c  'c
%"+cc

c H7Bc c c   c % c   c c %c  & c c  c +c c c c 'c
'c c H7Bc 'c  c #c %!c  "c  &c c  &c  c 6
&2 c 5GGG#c $' c
7007#c 1 c 70079+c   "c  "c c   c  c c &c c H7B:A:c c
%'c c& & cc2 c)*c  c c6  cc +#c700)9+c %& %c%c2cc)*cc
c&%  '#cc c'c% c ccc 'c!"c& c2c ! cc
H7B:A:c c 2 'c )*+c <%c  'c c ':"c #c !! c c H7B:A:c c
%'c c)*:''c' cc 2c  "c 'c &c& c+c c
H7B:A:c c c )*:A:c c &%c 'c %c !"c % c %c  'c "c !2'c c
H7B:A:c c c '&c c %" 2c )*+c ''#c c c )*c c %c H7B:A:c !  &'c
  "c &'c %c  c %"c %  c c H7Bc '"#c  '"c   c !'"c
 %c 'c c  +c %&c %c  &c  c "'c  &'c !"c  c c & c   c
&&c c 2 cc)*#c!"c%& %c 'c. c'  c 'c.. c   c6
 'c
7008#c4&c700)9#c%%c!&cc%c &c  ccH7B:A:c+cc
c
c c %'c c %c 2c % c % c ' c c  &'c c c 'c c c . c  c 'c
%" c  c %%c c  &c %c ' c  c !c  &'c c & c  c '&c c . c
 +c #c ' 'c !"c H7B:A:c &c 'c c !c  c % c !%c c   c
 % "c 'c 2 cc)*c c "c'cc  c%"+cc
c
ccc% 2c'&'c% c &c& cc 'cc c c % "c2 cc)*c
!&c % c  % "c '2 c c %c c c  &c   c  +c #c    c c   c c  c
 c c     c c c   c 
 c
c   c     c c   c  c c 
2c  c
c 
 c
c
    c  cc 
c 
cr
 c cc $c   c c c
c c c
  c
c  c c  
 c cc c  cc    c
 c&/c   c
  c

c
  c  cr0  c ccc**&c#c
c  
c c
cc
c c
c c  
cc c
2 cc c
c c
c   c cc c  c c  c cù c3c c   c c
 
c  c 
 c 
   c&/c   c   c cc,cc#c
c c   c
c  c c r  c
r c   r  c c   r  rrc   c   c  c   c c  c  c
    
 c —  
  c r#— c    c ' c     c  c c   
c   c
 c  r   c
c rc rrc c r  c r  c  
  c r'  c c c c  &c
#   c

 c c
   c  c c  c c     c  c   
c
c  c 
c
 
c&/c4
c&/c  
c      c2  cr'0-c  
c' ´ùcc)2$cc c
c c   c

c
cc   c$#cr*#c c c c  c 
c cc**(c  c
 c +c &/c   
c c  c 
c     c c     c  c    c  
 c c  c )2$c
 
c c  c c 
c c     cr  3
c ccc /cc 
c
c    c  
c
c
&/cc'0-c  
c    c c
 c c 
c
c  c 
  cc c
c   c

c 
c c 
   c " cc 
c 
2  c c5  c 
 cr'  c c
c &c c c
c  cc 
c
c  c  
 c   c c
c
  c
c 
  c 

c c   c
c 

  c 
 c   c  
   c c 
c 
c  c


  c  c   cc  
c c  c 
 c c
c 

 c
  
c 
c
c c

c
c 
  c  c cr-
 c cc c   cc    c

c

 c
   cc
 c c    c&/c2 c c   c  
c 
 c c  2c
r'  cc rcc'  cc
   c 
 cc&/c   c c   c c   c c 
c
 c c c c  c 
c   c
c )2$c c   c 
    c c c c   c   c
 
 c  c c   cc 

c
c &/c   c c  c  
 
 c   cc
  c  c&/c c
c
   cc  c

 c
c
#
 c     c c c 

 c c c   c c
  c 
c   c c   c    c 
c c

 
c  c     c c   c c c  2  c  c c c  
  c c    c
c
)/cc  c
c c&/c c  cc
 c
c c    cc c
c   c  c
c  c-  c cc***+c)/c  
"
cc c c  c  cc  
cc c
c  c

c    c    c c  c c )/c  


c c  c  c ï  c c 
c 
c 
2 c
c     c c   c '    c  
c
c )/c   c   
 c  c    c


  c

 c  c    c  
c
c     c 2 c #— c )2$c c

 
 c  2  c r,c 
 c c  c c 
 c )/c    c c   c    c  c
c    cc   c  c    c 
 c  c  c
c
c 
c c
 c
 c
 c
  c c  cc   c c c5
  c
c  cc  c
c
c  c


 cc
c
 c   cc)/c   c  cc
 c
c c    cc c
c   c  cc
 c  c
c c
 c c
  c    cc    c
  c
c c  c
cc   c
)/c c c 
 c   
c
c
c c     c c
  c   c 
c &/c    c
  c  c 

c
c)/c
 2 c cc +c  
 c  c&/c   c  c c 
 c
c4!c

c   
c

  c )/c  
c 
  c  c  c c &/   c )/c    c

  c 
c
c c     c c   c  c 
  c c  c  c  c  c 
c
   cc 

  c 
c
c&/c c    cc c&/ccc
c
c  c  c
c  c6
  c c
 c
c&/c c  c c c

  cc
c
c

c5
c '(c $ % "c 22 c )*+c c &!c c  % "c 2 c #c 'c '& #c )*c 2"c 'c 2 &c
& c&c
c
c
"#',/,+")'/#,1*&4&,#*+23%0*"0#(###$#'0#/0#',#.
 +*0# , , ',"' * "*) "# %0 *1   &* ' ++#''* % +*&*# /1#'+ (
+#0#, %%#  +*&*, ,#*&# &#%#. )"/# +*$%// # %, /1#'+ "* ,"
+*&***1%#//1##%'*'"%#' /'' ##,##*

c

cc
F &c55+c. c'  cc   c % "c ' cc)*c 2 c. c'  c 2 c$,,c6 #c  c 'c. :
$,9#c %%c  'c c 2 c c %c  c 6 ,5#c  ,79c 'c )*+c 2 'c )*c   c %c &&c c %c .. c
   cc 'c c2 &cc c'+c
c
c
Fc %c 1 c c  #c c c !2'c % c &c c %c  A  $c 6 c 'c '*: 'c
 A  :  c 9c c c c . c ' c c %c  c c c
 c c %c .. +c %c .. c &!;&"c  c 2 c c %c %c  c  ,5c 'c
& "c )*c 2 c 61 c 700B#c H&c 700*#c >c 70089+c<%c %c 1 c c  c  % "c c
'#c%cc"c2cc c. :.
1c 'c c%c.. c!"c 2  c%c c6   c
    c& '9c c6 c7008#c   c70089c6F &9+c  cc'& c
:% c c
 c . #c %%c %c c  c 2 c c '!'c !2c c  c c . :.
1c
6H&c700*#c>c70089+c cc cc&'cc% c 'cc&c c
c #c 'c%c  c cc#c&%c c% c &'c!"c%c%": c
'&'c!"c c c6.cc7008#c1 2 c70089+cc
c
. :.
1c c &'c!"c "c&c&' c. c! ccc. c '#c cc
 #c % %c  "c  ' c c '"& c #c 'c c '  &c 'c  "c % c
c61  c700B9+c. :.
1c;&cc #c%%c c!c %2'c%& %cc''c
!&c c && "c &2c % c c c :% &c 'c 3 c 6  9c c  2"c
:c% &c! c6 9c61  c700B9+cccc. :.
1c!%c c 'c. :
$,c6. :''cc 9c c 2 '+c 2 cc. :$,c c 'cc)*c%%" c
c c 5)c 'c *Dc 6$&;&c 70059#c !&c "c c  c c %c . :.
1c%& %c   c 61 c
700B9+c(c%c%c% '#c 2 cc c 'cc'c%%" cc)*ccc5)c 'c*Dc
6$&;&c70059#c cc c%%" c 'c 2 cc %c%c c6 ,79#c%%c c
%%" c)*ccc70+c
c
c
c %&'c !c 'c % c %c %c  % "c '!'c !2c 2 c c )*#c c %c c %c
%%'c*: : 'c c6$,,9Pc #c  c 'c. :$,P c c c%c ,5c 'c
 ,7c P c%%" c c&&'cc' c&! c%c c&cc. c
 c 'c c "c c 61 c 700B9+c (c  c c %c '! c c  c c %c .. c
&'c %c %%" c c %c %c 2  c 7 Lc c c c . :.
1c !"c c %c $,,+c
$%%" 'c 7 Lc 6  : 7 L9c c  c c  !> c . c  c c 'c  c
c  c 6c 70079+c 2%#c )*c  c c "c   c c %c .. c  % "+c .. :
' 'c&c )*c %%" c '&c !' c c%c A.7c 6%& A&c '&!c &c
79c &!;&c   c c %c )*c &#c %%c c &c c  c c &!;&c c !"c
" #c& cc)*c !> c 'c&c 2 c64 2c70089+cc
c
c 2 #c '' c c %c 2"c c %c c   #c %c  c c :  c
' c 'c%c& c#cc
59c )*c c c cc  c 2 cc#cc
79c  c  cc%c%' cc'&c cc
*9c 'c c >c'"cccc. c'  c 'ccc c6(c700*#c c700*#c c
%'c700)#c*C+c&%"c700B#c %c70009c
c

c c
c
<c% 2c!c'& c% c2 &c % "cc  cc 'cc 2 cc)*c!&c!c c
c "c&cc cc'&c%c2 &cc%c)*c& c'+c %& %c c
%"  ccc)*cc  cc2 #c&'c%c'c&c'c' c c' c
!  c!c%c&c&2c 'c c c&cc)*+c #cc'&c2 cc
%c&c'c6& >'cc !c!9+cc% c%c cc 'c  c%"c
c&c'#cc  #c &c  ccc%"c% c&c2"c "c69c c
!%#c% c  'c  ccc%"c% c c cc'2c6%A" 9#c!&c% c
&'c "c c&%c cc'2ccc  +c

c
c
c
c
c
c
c
c

cc
c cc

c
c
6c)*c 2"cc 'ccc&c6+ +c9c 'cc' 'cc c&c%%c ccc&&c'2+c
66c)*c 2"cc 'c c &'c!"c ccccc)*c  c #c&%c c+  'c?442+c)*c
2"cc' 'c c
cc%c c&c'#c c &'c!"c%c' cci #c c)*c  c #c 'c!"c ccF: 5#c%%cc
 "c'c
!"c':"c)*+c
c
c
'u80 null mice.

,&C0cc c. c cc% c  c%c,&D0ccc%c. :!' ccc. :


$,c 6%% >c 70059+c ,&C0c &c c %!c  'c  c %"#c &' c c %"#c
 #c % & c '  c 'c %'c c  c 6 c 5GGG9+c c  c c   c 'c
%c 'c. c'  c 'c&'c &cc%c  'c  c%"+cc&cc
%c %"%#c &c !"c !! c 6F9c '2'c c ,&C0:A:c c  "c &'c )*:
''c  &c  2c +c c ;&c c )*c  c & 'c !"c %c 'c
 2c   "c c ,&C0:A:c c  'c c ,&C0:A:c )*UA:c !! c 64c 70009+c %&#c )*c
'"c &c %c  &c  2c c c ,&C0:A:c F+c #c c & '#c  'c
. c '  c 'c  'c )*c 2"c c !c c %c  'c  c %"c c ,&C0:A:c
#c  c %c  c %c )*:'c c  %c &c %c  'c  +c  "#c
c'cc!%c,&C0c 'c)*cc&%cc :c% cc% cc'c"cc
)*c 64c c +#c 70009+c %c  c c  c 'c  c   c & %c c !&c "c ! c
c % c c c )*c  %c % 2c 'c c %c  'c  c !2'c c ,&C0:'c+c
 "#c c c )*c  c &c  'c  c %"c c  c 'c c '   "c
 '+c
c
Telomerase-deficient mice+cc
 c c c "c >"c % c   c c  %c c c c 'c %c   c +c
.c c  c >"c c  'c c c '"&#c & c c  &c  c
%"c c c 'c '" c   #c %%c % c c c  &c  #c c %& c
6 c c +#c 700)9+c."& cc c >'c!"c%c. c c %"c c. :.
1c
'c %&c 2 c %c .. c 'c )*c 6 'c c +#c 700)#c '= '' c c +#c 700*#c2cH c c +#c 700)9+c
c'cc%c c  "c&!&c69c6 :A:c9c cccccc c
&#c 'c  c  c  c % 2c c ' 'c c  c 'c %c ' 'c !'"c  %#c
 'ccc 'c' "'c&'c%  c61 cc +#c5GGD#c &'%c5GGG9+c1 &cc% 2c c
#c  "c  c  :A:c c c %" "c  c 'c % 2c c  c c  +c
 "#ccc%c &c  c%"c!2'cc c  c :A:c c&'c!c
&'c!"c)*c'"+cc
c
%c &c ' c % #c c  c c c  :'c !  &'#c %c c 2 c )*#c
%%c!&cc &c  c6%c5GGG9+cc
c
c
c
ßmpste24 protease null mice+cc
H7Bc c c   c % c   c c %c  & c c c +c 4 c c c c  c
cc%c& c2#c'cc%%c c &c &c  c%"cc%& c
'c c 6
&2 c 5GGG#c $' c 7007#c 1 c 70079+c
c %& c %c  'c "'c % 2c
!c %c c  "c & c c %c c ' c 4 c c c c c H$
7Bc 6%c 700*#c
c 700*9+c c & "#c c 'c c H7Bc 'c  c c %!'c  "c  &c c
 &c  c 6
&2 c 5GGG#c $' c 7007#c 1 c 70079+c   "c  "c c   c
 cc&ccH7B:A:c c%'c c& & cc2 c)*c  c c6  c
700)9+cc
c
%& %c %c 2c c )*c c c &%  '#c c  c 'c % c c c c  'c !"c
& c 2c ! c c H7B:A:c c 2 'c )*+c <%c  'c c ':"c #c
!! c c H7B:A:c c %'c c )*:''c ' c c  2c   "c 'c
 &c& c+c cH7B:A:ccc)*:A:cc&%c'c%c!"c% c
%c 'c"c!2'ccH7B:A:c cc'&cc%" 2c)*+c''#ccc)*c
c %c H7B:A:c !  &'c   "c &'c %c  c %"c %  c c H7Bc
'"#c '"c  c!'"c %c 'cc +cc
c
%&c%c &c  c"'c &'c!"c  cc& c  c&&c c 2 c
c )*#c !"c %& %c  'c . c '  c 'c .. c    c 6
 'c 7008#c 4&c 700)9#c %%c
!&cc%c &c  ccH7BQAQc+cc
c
c
BRCA1 hypomorphic mutant mice+c
1  5c c c &c &c c % c c !%c c c %c c 'c . c '  c  c
c6H%  c700)9+c !&cGCMcc!"c " #c c%"%c& cc1 5c61  5:55A:559#c
'c !c ' "c 57c c 5Cc c  +c  "#c % 'c c c )*c "c &'c %c
!"c% "#c  c1 5c :55A:55c cc&22cc '&%'c6L&c70059+cc%c '&c  #c
1 5:55A:55c)*UA:c c'2'c&c% c c%!'c  'c  c%"+cc
c
"#'# 1,' ' ,,#' " ,#*&% '(/  4 &,#  # *    #1%#% /# * 
+ %%# +"#*+#  1#&/#'
 "# /'* #0#/  '%#*  )"%" %#'# 4 &,# 
%%#'+#&/#'&#' /#&,"+#%0#+23//#/#.)"%"%* /+*&*#%%#/##
,, *3+c c' c%c% c''#c%c :%7:)*c.. c % "cc 2 'c&c
1  5c'"ccc6 c70089+cc%c c ccc)*cc%c.. #ccc
% 'ccc cc%7c&'c%c1 5c'":  'c!"c% "c 'c  'c
 cc '&c& c+cc
c
%c ' c c c %c c 'c c %%c 1  5c '"c  c c . c '  c
 #c%%cc&cc)*c%" 2"c%& %c%c.. cc c 'c%7c6cF &c
G9+c c  c  'c  #c !c c c c %7c 2c %c %" 2"c c )*c  &'c !"c
1  5c'"#c%c%cc c&'cc  'c  +c&c'c% c c)*c
'"cc
c
c
c
c
c
c
Short isoforms of p5V in mice: The p5V m micec %c c 2'c c c 'c c c )*c c
 c  c %"c  c c "c c +#c %c  'c c c %%c c  &c
! c2c''c c%cc. c& cc%c&c)*c c% c&''cc5K8c
c%c)*c' c;&+c%c& c)*c c6c 9c 'ccDK55c 'c c&'cc
!c&'c%c  ccc ccc c& c +cc
c
c%cFc 'cc)*UAc c' 'c% c%cc c'&c&'c% c%c
 !"c 'c %c  : 2 c 2"c c )*+c c %c c  c c )*c 2"#c )*UAc c
c "c c c c5Cc%cc c 'cc "c 'c)*UAUc+c
& "#c
%2#c %c  c  c )*UAc c % 'c c 70K*0Mc %c c  +c 2#c %c & c c
%!'c 2 c  c c  'c  c &' c &c %"c 6c %c #c  c &#c 2c
'c "%'c  9+c %&#c % 'c )*c 2"c &'c '2c  c %"c c %c c c &c
&#c c cc%c& c+cc
c
c c & 'c% c%c  'c  c c &'c!"c c 'c !"ccccc'&c
';& c&!cc c 'c &c' 'c+c cc  "cc% cc
c'" cc)*UAc c'c% #c 'cc':"c#c%cc%!c c'&'c
&!c c   c % c c c %c +c 'c &"cc )*c 6)*UA:9c   "c
&'c %c '&'c % c c c  2c  #c & !"c '&c c '%'c )*c
2"+c
c
<%c%c%"cc)*UAc c& c% c 'c)*c 2"cc&c&c c
%ccc  #c%c cc 3c 2 cc'+c7'. #*"#/*)#$+#''*/#0#/*1"#&
//#/#  +23>´& '' #'. * &#0# +*# %* / (# ##%#
c Ô#%*.  &*# &+*. "#
-*) '#%" *1 4 +'#& *1 "# +23 ,## " )' #/##  "# & //#/# "' #%#/ (##
%"%#@# '"*)*%/ # +'#&,##'**"#+23 %*?#2+c
!cccccc%c7Bc c cc#c 2ccc%c  'c  c 'c c
 cc%c)*UAc+cc
c
Short isoforms of p5V in mice: the P  mice+cc

&!;&c &'c c "c 'c %c ' c % c )*c  &c  c '& c   c  c !&c
2'ccc%c ! &ccc%c !2c&'c689+c cc +c 'c  cc
% c 2:'c BBc 6 c %c  & "c & c )*c c % c  c %c  c  : 2 c
' 9c 6$UAUc9+c 1"c Bc %c c #c $UAUcc %'c 'c  c c  &c  +c 1"c 5c
" c c #c c c %c $UAUc c % 'c ''#c % c %c :  c c c c 2c 'c
% %"+c
c
$UAUcc % 'c c2"c c 'c c  #c &  c % c BBc 2c  'c ':"c
)*c 2"+c ''#c%c 2:'c BBc %c c'& 'c )*c&c !"c  : 2 #c
& c c % 'c 6 c  c c  c c 6 c c  ! c c  c
)*c  c c c $+cc   cc&/c 
c c

  c
cc  c
c c  cc
c
 c  c  c 
 c
cU´Uc  cc
c
c c cc c cc
c   
c
c c
   c   c    c c %.c c   c c    c 

 c #2c c .
2 c r.-6c
r.  cc
 c
 c c  c  
c
c%.c6
"   c /+cc  c  c /+c 
c
 c c    c    c c   c c c  c U´Uc 
 c 
 c c c 

 c c  c    c c %.c
   c c  
  c 
c  c  c   c  
 c
  c &/c

c  c   c
c %.c  
c
ù  c **)+c c 
c

c
c  c   c r c   c 

 c   
c 
 c  +c c  c
   c
c cc  7
 c
 c,81c c c c%.c   c c 


c
c

  
 
c 
 cr,,/cc
,81c  
c c   c c
 c  c
cU´Uc  c   ccc   c c&/c 
c c
c  c 
c c
c c  
c
c c%.c   ccc  c  ccc
c
 c c c
 c U´Uc  c  
c
c  c %.c  
c r%.c c   c c   c c
 c
cc
   c
 
c  cr  cc c c
c c  c
   c
c 
 c c cc
 c  c c  
c 
 c  
 c  
c   c  c     c 
c
c $$c 01#c
  c  c  c
c%.c
 c   c
c
2c

c  c&/c  c c  c
c%.c
 
c c    c c  
cù  c**)+c
 c
c
  ccc

  c ccc
 c&/c   c
  c
c c  c  c 
 c
cU´Uc  cr c.  cc. c c
 c   c 
c  c   c  c   c  
 c c U´Uc  c c  c 
c 

c
c %.c    c
cc
c    c  c c 
 c  c c c   c   c c   c  c
   cc
c
 c

c    c     c
c  c U´ c "c c U´Uc 
 c 
 c c  c    c
c c

  c c   c c  2 c  c   c &/c  
c
c  c U´ c c  c U´Uc 
 c 
 c

 c  
c
c1  c  c&/c 

cc  c&/c   cc c c
 c
 
 c c  c 
 c c
c
c c   c 
c c   c
c c   c c  c c
 c c $+c c c 
 cc c c
ccc

 cc  c  c
cc c
c&/c


c 

c  &+c    c 
 c  c 1  c  
c   c 
c $$c  c c  c  c

 c 
 c cU´Uc c U´ c  c c c c
cc  c  c
c&/c 

c  
c
 c 

cc 2c c1  c
c&/c c c
c
c c c    c
cc  c&/c
c
  c 

 c 

c  &+c    c c   c   c 1  c   c 

c
c &/c
 c  c  
c
c   c &/c  c  c c   c &/c  
c c 
c  c c
 c
   c c&/c 
c
  c
c c  c 
 c
  c c c U´ ccU´Uc 
 c
 cc

c c     c 
c     c   c  c     c c c c  
  c 
c  c  

 c 
 c
cU´Uc  c c  c c c U´ cc "c
 c
 cc c
c
c
c
c
c
c

c
c5
c '0c Fc    cc'& 'c !"c )*+c ! c )*c 2"cc iU´Uc c  'c c  'c  c !"c
 c %c Fc    c  % "+c c ':"c c 69#c )*c '& c 'c   c %c  c & c
 c2 cFc 'c75+cciU´Ucc6 %9#c)*c 2"c!cc'& cc%cFc   c % "c
c ' '#c & c c c 2 c  c c %c   c  '&c  % "+c c  #c )*:' 'c
cc75cc '#c c& c +c%c 'c)*c 2"c 'cc  'c  c c
%c2cc%c%c +c%c c 'c' cc2A 2"cc''c!"c c cc' cc
!'c%#c2"c
c
c

c%&'c
c
c
 c c c   c 
 c "c c
 c   
 c c  c c
   c  c "c
 c
 c
  c c
 c
cc   c    cc  c
c cr/&cc c
  c c  c   c   c  c  c  c 
 c  
 c  c c



 c   c 
c
   c  c c 
ccc   c c 
cc c +cc
c
c U´ c  c c
 c 
  c 
c   
  c 
c "c  c  c c 
 c    c c 
c    c    c 
c


c  c  c
c    c c c 
 c c
  c c c  
cc c c c
  c  
c c c 
 c    c 
c 
c  c   c &/c  
c 6
  c  c 
c
  c c  c 
c  c  c    c   c  
 c  c  c c
   c 

 c
c  c        c "c 
 c  c  c c c


 c c  c   c r  c  c
   c c   cccc  c
 c c c

 c  cr  c2 c  c  c&/c   c


 c 
  
cc  c
c   c c  +cc
c c     c
c   c  c&/c
  
c   c c  c  cc  c  c
c "c c
c
The super-p5V mice:
c

 c

 
c&/c
 c
 c c c c    c
c  c   c c  
c
c
 
 
c 
 c 
c &/c c c   c c  c    c c  
  c  c   
c
 
c
c c 

c  c8c c
c  c c  c  c c c  
c
c&/c

 c c c c cc c
c
c
c c  c
 c# c***cc%
 c**&c12c  *+c

  c  c  c  c
c
     c &/c c #   r c   c  &+c c  c % '
c c c
  cc    c  c 


 cr #'c  c c
 c
 cc  c c
 c
c c
  c c 
c % '
c  +c c  c 
 c 
 c &/c  
c c   c c  c  c     c


c 
c c  c 

c c   c   c 5 c &/c  c   c c    c 01#c  c
 
 c c   c 
c 
c c 
  c  
  c c  c &/c c 
   c c
  c c c c
 c
c c  c  c
  c c  c c  c
c 
c
   c c  c
9cc
c
1
c :c 5 c &/c  c  c 
c c   c c   c c 2 c  2 c 

2
 c c




 c  c  c cc
c c  c
c &/c   cc    c c
c c c %c
!'"c  ' #c &:)*c c %'c 2 'c 2c c 75c   c c c &c 'c  'c
c c %c %"&#c  'c c  ' 'c c +c   c  c   c  c  c c
 c   cc
c
c
c c #' c  c c cc5 c&/c c c
c c
  c
c &/crc*#c
 c
c

c  c c 2c
c
 
c  c c    c c&/
   c
c 
ccc   c  c 
 cc
c
 c cc
  " cc c c  c
c&/c
c c
c c   c c
 c
c   c  c
  
 c c   c
cc 
 c c c c   c
c   c&/cc  c  c  c c c

 c c 
 c  
c
c *#c    c  c  c  - c  $+c  c  c c c  c

 c &/c    c  c   c c "#c c  c %c % c %c '&!c &:)*A5G Fc
c  c 2"c  c c % ! c :  'c c . c '  c  c c %c
!cc "c &cc  'c  c%"+cc #c%c&)*Ac5G Fc  cc
 :#c %'c  'c  c c ' 2c c 'c ' "'c  c  c c ' "'c
 c6 %&c700D9+c%c &%c& 'c% c '#c!&c"c & 'c)*c 2"Jc2'c
!%c c  c 'c &c &c 2"+c c  c c !c c c &:)*c c &:
)*A5G Fcc' "c  'c  c%"c%c&'c%c"cc%c+c
c
c
2#c%c  'c  c%c!"c :&cc cc&%c  'c%c%c
c c 'c %c &:)*c c 6  : #c 70089+c c  c !2'c % c c % ! c . c
'  c '&c c '2cc c c "c  'c c &:)*c c c  'c c
':"c #c %& %c )*c ''c c % 2c "c c c :'2c  +c %c &%c & 'c
% c%c' cc'  'cc ccc c&c &'cc' "c%c % c  'c
%c  cc+cc
c
The hypomorphic Mdm2 mice:c
#c c
c
cc  c  c&/c c

  c&/c 
c c
c  
c
c c
'7c !'c %c   c 2 c ' c c )*c 'c 2c c  c %c %c
  c  %"+c '7c c   c %c & c c c )*#c 'c &!;& c )*c 'c
cc'  ' c!"c%c +c   
 c
 cc
c
  c&/c 
c c
c    c
 cc  
c
c   c '7:'cc c!"c% Jc'cc)*c&c%c
% "#c '  c % c 2"c % %c 2c c )*c c  !c %c !"c '2c 6 c
5GG)#cc5GG)9+cc
c
c
c  $c
c c
   c  
 c c    c  
  c 

 c r1,/ *c c  c 

 c
c  c
c  c  c c   c c   c
c  
c 
c  $+c ' c 

"
c 
c  c c


 c  c  c  
c
c c c    c 
c 

c c
c c


"
c 
c  c c   c  c 
c c  
c c  c
   c 
c c   c 
c &/c
   c c 
 c c  c c   c c c 

"
c  c c   c 
c    c  c   c
c 
c
  
 c c 7.  c c
c cc c  c
c c c.
c c
c
c    c
 c

c
  cc   c c  c  c&/cc c c  
ccc c  
c
c

  c
   cc
 c
  cc
c
,

c  
c
c c c    c  c c   c 
c    c &/c  
c  c  c
 c   c c 
  c    c   c .
c  c   
 c 3 
c
c  c c 
  c
#cr   
c
c &/cc  
c
c
c c 

 cc  cc 
 c&/c
cc
 c c
c 
c c  

  c  c c* ;c c  $+c#c
c    c
c   c #c   c  c   c
c &/c 
c / c #,,c c , c c 
c 
c 'c c c c

c c / c  c &/c c
c     c c    c c  
c %c **(c %
c  /+c
 
c
c #,,cc, c   c c   c c 
   c  c
c#c8 c #,,c
 
c c 
c c 
 c  c 
c  c
 c    c 
c    c 

 c     c
 /+c , c
c  c
 c c c c   c c "
  c &/c c  c 
c   c c c 

 
c 1 2
 c  /+c  c  
c
c c  c  c 1 c 1 /c c c

c c  
 c
c 
c &/c c    c &/   c 

 c !  c  $+c  c   c
c  c 1 /c  c
  cc* ;c   c c
c 
c
cc 
c
c c


c c  c<#c   c

c

c   cc  
c
cc
  cc
 c  cc
c   c c!  c
 $+c
c

 "#c &c 2 c c )*c c '&cc  c '7c !&c  " c c '&!c )*c c  c
 !c%c&22 c6  % &c70089+c'" cc +670089c  'cc% ccc2c
c'7c6'7c &A:D:57c 9c cc%cccc%"%c6&9c 'cc&c c6:DK
579+c%cc'c*0Mcc%c c2cc'7c6'" c 7008#c '" c 'c $"c c +#c 70089+c
c '#c %c c c %'c  'c !  c 2c c )*c '#c &c 2 #c  'c
cc)*c  c c cc c 'c cc%c c+c'7c &A:DK57c c
c c % %"c  c c  #c & !"c c c ;&c c  'c )*c 2"+c .c
% 2 c  'c )*c 2"#c %c c % 'c c  c c  #c 'c %'c c  c c  'c
 +ccc
c
c
% '
c c
   c 
  " c c &/c    c c  c  c 
c    c   c  c  c c

  c  c  c  c c  c    c &/c    c c    ´(7c  c 
c 
c
  c  c c
   c c 


c
c    c =c r   c &c c c  c  )+c  c c  c 3
c



c  c c   c  
c c 2c
c cc c
c   c  c  c
c c c    c&/c   c c
c  c  c
cc ccc    c c&/c 
c

 c c 
c  c 
c  c   c #c c  c  c
c  c 5 c &/c  c &/c c   c  c

c

c c  c

  c
 cc 
cc c   c
c c  c  
c
c
 c U´ c "ccU´Uc 
 c
 c
c
(()c c
c
)) c cc
c
 c 
c c c   c 
 c
c    c
 c c" c +c' cc
 2c  c 
 c  c    c    c 
c 

 c c 4!c  
c
c 
c  
  c   c
'
  c  c  c    c 
 c
c )) c c  c c ))   c  c  c c   c   c
c   
c ***+c ! c     c  c &/c 

 c  
 c c   c  c c

  c
   c c    c &/c  
c c 
 c  c    c 
  c c  c c     c 
c
    c  c  c &/c 
c
c5 c&/c  c c c c  cc    c  c
c
)) c   cc
c c  c U´ ccU´Uc  c 
c  c
c

Aging and human p5V polymorphism at amino acid 72


 c  %#c %c &c 'c &c %c ' c % c )*c c c c &c &c % c  #c
&'c c & #c c c  +c  %c c %c c c )*c c  c c c '2'c
c &'c c %& c & +c & c )*c % c c $A  c "%c c c 'c '&c D7+c
& c  " c c c c c c %c $c c  c )*c c % 2c !c &''c c  c
&!"#c "c 'c&22 +c%c&c&c ccc)*cc &  cc cc%& +c c
c " c  &c &2"c 'c !"c 2 c c c +c %'c % c %& c %c %c $A$c
"c% 'c c% %ccc'2 c c 'cc%c  A  c "c61 c700B9+c%c
' c c%c c2&c' c% c)*  cc ccc'&cc c% c%c)*$c
c 6.&c 700*#c2 c c 700)9+c c 2c &'"c 'c !"c %c  c &c c 5778c &!3c
'c C)c c 2c %'c % c %c $A$c  c % 'c c B5Mc  'c &22 #c 'c c 7+)B:'c
 cc c "#c 'cc%c  A  c 61 c700B9+c%c &%c& 'c% c
c 'c &22#c )*  c 'c c  c c "c % c )*$c !&c c %c c c c
'%'cc +cc
c
c %c  #c ('c c +c &''c c   c . %c & c c G75Gc   c 'c 70KG)c
" cc 2"#c&22 c c c' #c 'ccc c6('c700D9+c%c &%c&'c
% c 2 c 57:" c &22 c  c % %c c $A$c  c  'c c  A  c  +c 2#c
%& %c$A$c c% 'c%c c cc c  A  c #c%c&22 cc$A$c'2'& c
c  c c c c %  c ' c  c % %c  'c c  A  c '2'& +c %c &%c
& 'c % c %c  'c  2"c c $A$c '2'& c c c  c ' c c %c c
%  c' c %c c!c'&cc c cc&22 +cc
c
#c  c c c c c )*c % c c c c c '&c c c % 'c  'c &22 c c
#c &  c % c % %c )*c 2"c &'c !c ' c c %& +c <%c 'c c #c
 c !&c %c  & "c & c "%c 'c c  c c  c ! c c c
c%c'  c! 'cc&c'c'!'c !2+cc
c



c c
 c cc c 
c  c
c  c
 c cc &c 
 cc  
c
c&/c  c c 
c
c cc    c  ccc c
c
c   c  c
c
c0&/c  c   c c 
c  c c    c4#7%#$c
 c  c  c
c   c 
    c &/c 
 c c c '  c   c c  2c  c 01#c
  c
 c c
c
    c
ccc&*6ccc  cc
c
c c c
01#c   c
 cc c
c   c
c   c01#c  c
c c
c
c&/c c
c  c
 c  c0&/c c 
c c01#c1 
c  
c
c  c
    c 
c
c&/c
   c c  cc
c c c   cc   c&/c 
c  c
  cc  c c
c cc#  c
cc
 c  c# cc c  $ c ccc c
c %c     c 
c %c c   $ c   c %c #c c $
 c

c 
c c
 c c c  c &c  c  c c
  c  c  c    c c  c 
c
  c 
c 0&/c r# c  c  c c 
  c   c c c c
  c  c  c  c c &/c
   c c
 
c  c  c
  c
c
    c c
c
cc     c  c0&/c   c c 
c  c  
 cc
 c c  c c c
   
c
c   c &/c c c  
c  c 
c

  c   c  c

c  cc0&/c  
c  cc  
 c c   c
c 
  c
c     c c
c 
 c c 
c  
cc  c    c 
c c
  c
c0&/c  c
 c
c   
 c  c c    c 0&/c  
c   c #   r c   
 c c 
c c 

 
c c   c

  c   c c 2 c 
 c   c    c   c c    c
 
cc  
c
c&/c 
c   c  cc  c  cc    c
c
c 
c
c   cc&/c  c
  c cc 
 cc c    c c  cc c c c
 c c 
c   c
c0&/cc  c c
 c c  cc  
c c 
 c  
c
 c  c c  c 0&/c    c c   c  c 
c  c c  
c    c c   c c  c
 3  c
c 
 c  
c  c c  c c
  ccc   c c&/c   c c
 c
c c
  
c
c c 
 c  
  c  c    ccc c
  c c c
  cc
   c   c
c&/c

  c  c

 cc  c
  c
c  c c  cc
c

c c
  c 2cc
   c    cc U´ c  cc  c  
c
c cc

  c c c  c
  c
 c )+c. c    c
c c  c c c
c


  c cU´Uc  c


cc
c
c %c  c c '&'c %c 2 &c "c c c  !"c % c &c %c +c c
&'c c 'c "c c . c  c % c %c c 'c '&'c %c
%"cc 'cc 2 cc)*cc &c  c  cc%cc&'  c
& c2+c<c c c 'c  c'c%c c<c c% c& c c
c&cc! &cc'ccc 2c 2ccc+c%c
c  c % c)*c ' 'c & c c c '"c &''c%c %cc
& cc2 &c'c +c<c c% cccc& c &c
  c %  c %%c  'c c c c $c 'c %
c  
c c 

 c
 cc
 c c  c 
 c c  c  cù c
cc'c    c  c c    c&/c
c    c  

 cc cc  c01#c  ccc
c
%c &c &c )*c c %c c !"c  c %c  c c  "c   c
cc%c. #c%!"c2 c& +cc ''#c)*c cc c%c cc
'  'c c & c c !"c %c c c c 'c & c +c 2#c %c c
& c 2'c % c c 'c & c c  c  'c c  c %"#c !"c !"c
'cc ccc 'c%c cc+c%&#c  cc. c'  c   c
!"c)*c% c!c>'cc!  c%c! ccc&c&c c%c' c
cc&c'  +c. c c  c
c&/c  c
 c c  c  cc% 
 c
  c 
c    c  c  c c c  c  c   c  
 c c   
c
c &/c #c 
 c
   cc
  c
c&/ccc c
 cc c  c 
 c   c
c c
 cc
c  c  c  c 
c   c  c 
 c  c  c 
c 

c
c &/c 
c  c c

c
 cc  cc
c
 c   c  c
c c c
  c 
c &/c c  c    c    2c 

c c 
 c &/c
 
c   c c   c   c c    c  c 
 c
c  c 
c  
c c  c   c

c 1
   c  c  c
c c   c 
 c
c   c &/c  
c  c   c &/c c c


c
c  c c  c c. 
 c c    cc

 c cc c c  c
c
   c  
 c c   c 
 c 
  c  c 
c  c 
c
c   c c c  2 c
  c 
c   c c c . c  c 
c  c 
c     c  c  c
c 
 c   c
  c&/c  c  ccc  c c
c  cc
c  c  c 
cc  c

 c  c     c c c
c  +cc
  cc&/c cc c c
 c  c  c
% 
 c   cc c    cc
  c  cccc
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c

 c
#   c 6c %
c c 
 c c 1
c c #  c    c
c    c 0 c ,
 c 0  c
'
2   c  c /**>(&c,  >c) =+c
c
c %'#c
++#c. #+#c&''%"# +#c  #F+#c '#+#c "#+#cF '#+#cL&#+#c%#1+$+cc +c6700)9c2'cc%c
'c!' cc%%" 'c)*cccc. c! cc22+c c +#c8)#c50C50K50C75+c
c
:1 #c+ +#c(%#c+#c &%#c+ +c 'c,#c+ +c6700)9c  "cc:'&'c'  c 'c cc"& c 'cc
%& c' c!! c& c%cc  "+c%+c  c.2+#c578#c88BK8D7+c
c
# 
cc%
cc? c,c cc c  c  cc   c
c
   c c c c c'  c c ( >&7
c,  >c($$)$/)+c
c
# 
c c -   c #c  c c ! c .c 
 c<c   c 

c  
c c c
  c  
c c
c c  
 c    c c c   c 

c 

 c  
c c   c 
 c '  c  c  $*&>*(7= c
,  >c&$=)/*+c
c
# cc # 
c #c<  c #@c'  cc c8c  c  c &/c  
c c  c  c  c  
  c 
c
  c
c    
c  c
c

 c
 c***=r$(>)&7)&/ c
c
' #c,+ +c 'c
!#c +<+c6700D9c c&'c2cc! cc c:''ccc & 'c!"c:
   c' +c. c  c6 9#c8#c8G)KD55+c
c
#  c -#c  2c c
2
2 c c c c 2 c #c 
   c 
c 

 c  
c 2
2
c  >c
  
c
c   c   2 c 
c  
c  c    c c 
 c   
c 8
 

c  &$)>=&7) c
,  >c&$*===+c
c
#c1++. c'  cc&c'cc"cc!c c 3c &cc +& +c +cBD)#cDK
70+c7005+cc
c
#c ,+#c .& #c (+#c F!&#c +#c " '#c $+#c $ #c +c 'c 1 #c +c 6700)9c c 2 c c . c  %c  c
  "c&'c  c&&c'c 'c&'c'c c& :%"  c%  cc %& c.BUcccc
'cc'c +c+c+#cB0#cGD8KGC5+c
c
#c,+#c " '#c$+#c.& #c(+#c1 #c+c 'c1 #c+c6700B9c c2 cc. cc c  "cc%& c
.BUcccc c c&cc cc2+c+c+#c*G#cBG5KBGC+c
c
%#c+cIc #c+c.&c%' c. c& c && cc  c%& c
&+& + +c7D)#c5)DK58D+c5GG7+c
c
#
c4c2cc  c<c@ c  c 
c
c01#c  c1 c***/*(>/ c,  >c**& $/+c
  #c +#c%& #+c 'c #1++c670009c c%'cc' c ! ccc2 cc :''c%  cc! c
c +c$+c c  '+c
+c
#cGD#c8C8K8G5+cc
c
1 % #c +#c  #c+ +#c ' &>#c,+ +#c."#c +.+#c1&&#c + +#c.O#c++c+c#/+c 'c::c
2  cc ccc  c&c% + &cBB5#c5055K505B+c7008+c
c
1 % #c +#c  #c+ +#c ' &>#c,+ +#c."#c +.+#c1&&#c + +#c.#c++#c '#c +1+#c%%#c+1+#c$#c1+ +cc
+c670089c 'c::c2  cc ccc  c&c% +c &#cBB5#c5055K505B+c
c
1 % #c +#c  #c+ +#c ' &>#c,+ +#c."#c +.+#c1&&#c + +#c.#c++#c '#c +1+#c%%#c+1+#c$#c1+ +cc
+c670089c 'c::c2  cc ccc  c&c% +c &#cBB5#c5055K505B+c
c
1 "#c ,+ +#c  2#c ++#c Ic $&#c
++c && c c & c 'c  c c c  c & c
A c+c  cc*#c*G5K*GD+c700B+c
c
1 '#c .++#c #c +#<"':% #c .+#c Ic , #c .+c 2c c 2  c 'c & %c c c
c%& c+ +c+c**#c70*K70D+c700*+c
c
1 #c+ +c 'c,  #+1+c6700B9c  c& cc+c#c55C#cGK5D+c
c
1  ! #c +
+#c#
+c 'cF#+c6700)9c%' #c' #c 'c  +c#c570#cBC*KBG)+c
c
1 '&#c4+c 'c%#c<+1+c6700)9c c 'c  c c&c c2 c2+c +c 2+#c)#c8))K887+c
c
1 '" '%" "#c .+c Ic ' #c ++c %c   c c c  c c & c 'c   c  +c +c
+c*C#c57GGK5*0D+c700*+c
c
3c%c. c cc  c c1 
 c $(>&*&7) c,  >c&/($)( +cc
c
1 2 #c +#c > #+#c4#+#c,   '#$+#c, #.+#c 2 #+#c &#4++#c, #+#c&#,+cc +c670089cc
( :'&'ccc cc%c& c! c'c!"c. c'  c%+c &#cBBB#c8**K8*D+c
c
1  #c + +c 'c #F+<+c 6700B9c %c & c c c  c 'c   'c . c '&!c  'c ! +c . c  c
6 9#c*#cDC5KDG8+c
c
 c <6c ,

c ,'c %0  c 6c # c <c 6 c c 1 


c  
c
c &/c 
    c 
 c c c 0

 c
 
 c  c  cc'c
c &&r> )/7 )=c
c
c <#c , 
c -<c , c 1c c c   
c 
 c  c c  c
c  c
c c   
 c  c 1 c
 )$$$>//(7$c,  >c( =)*+c
c
c 'c ù 
c 6c 
c <c   c  c    c
c  c  
c   c " c
c 

c 
 
 c
 c c 

 c,
c1c# c c4cc#c / >($)&7( c,  >c(**$)(+c
c
1 &3&#c ++#c , # +#c  #F+#c   #+#c 4#
+<+#c  #$+c 'c  # +c 6700*9c 2 c c %& c & c
ccc%c)*c 'c58c % "+c1(c +#c77#cB757KB777+c
c
1c%&' #c +#c!# +#c,%2"#c
+#c1 c(#c +#c,'#c+#cF' '#c+#cF' #c+c 'c1c%&' #c.+c670009c
 c 'c%c %c c"+c%+c  c.2+#c575#c5D*K5DG+c
c
1:1 #c$++#c<#c +#cIc1&#c.++c :  'c 2 cc  "c'c cc%c
&+cc58)#c70))K7087+c700*c
c
1 '#c ,+#c && # +#c
 #+ +#c ' #++#c   #,+#c 1 # +#c !#+c 'c &'#,+ +c 670089c  #c c )*:c
'&!c & cc ""c 'c +c#c578#c50DK570+c
c
   c0c c@c1 c1<c  c%c'

2cc6 c<-cc rc #,,c




 c cc2 c  
c
c&/c
  c
c
c

cc! cc /VVr>)7)(c
c
1 #c +(+#c  2#1+#c # +#c
%'#<+,+#c  #+#c ,' #4++#c %# +#c  #+#c  # +c c +c 670079c H7Bc
'"c c c  &c  &c !c  &#c &c  #c 'c c  c c  c '+c $+c  c  '+c

+
#cGG#c5*0BGK5*0)B+c
c
1 #+ +#c 4# +<+#c '#+$+#c
#+#c4 '#$++#c.$%# + +c 'c'#+<+c65GGD9cc% c 'c
&c c!"c&cc  c c  +c#cG5#c7)K*B+c
c
 cc-c c-c'c8  c
  c c c 2  c c  c 
c c 
 c  cÔ c /O r&) )>&(7&($c
c
1' #c ++#c(&#c+#cF#c+# #c
++#c%&#c+$+##c+1+c#/+ccc: c!"c'&c
c cc c%& c+c
c7DG#c*BGK*)7+c5GGC+c
c
1'" #c +.+#c % 2 #c +#<#c ++#c Ic ,% #c ,+cR&  c 'c ;& c c  c ''c. c c
 cc2'cc  "c'& 'c. cc 'c%& c&+c &+c+c+c50#c5DK7B+c7005+c
c
12#c +#c% &'%&# +c 'c % '# +c6700B9c%ccc' 2c'  c 'ccc  +c%+c  c.2+#c57)#cC55K
C78+c
c
1 #+#c
2#
+#c1 !#+#c  #+#c#F+#c
#+#c2' #4+#c #+#c #+cc +c6700B9c%c'c c
 cc%c)*c'cD7c c c%c cc 'c'& cc22c%  :'&'cc' %+cc. %c.+#c55#c
G87KGD*+c
c

c%c6cùc
c88c
c6c"2 c%c#c1'cc rc#c   c 
  c

 c c c0c

 c  c c&/c

c 
ccc   c
c

c cc' c $*r&>&*7) c
c


 cc
c'c, c.c cc c  c  c  
c c    c4',c c   c c c,
c
c
 )$> /c,  >c)/))(/)+c
c
1&#c
+.+#c 1' #c 1+ +#c #c .++#c .&!2 #c +#c  #c + +#c % #c +c # /+c  c  ' :
 'c &  c c c %c c 2c . c ;&c c &  c   c 'c ! +c
' + +c58)#c7BGK78C+c7008+c
c
1&=%#c .+c Ic 1#c + +c c   %c 'c  c  2 c c  c c c   c
.*4+ &cB*5#cG8KGG+c700B+c
c
1&'# ++#cF '#,+#c & ":H3#F+#c 4&#+#c.# +#c L' #.+$+#c
2#+,+c 'c 4 #.+$+c6700)9c)*cc
 c & c)*c  c 2"+cc.2+#c5G#c7577K75*D+c
c
1"#c +#c,#c+ +c 'c$ #c++c6700)9c  "cc'ccc"& c 'cc%& c' c!! +c  c
#cB#c7BDK7))+cc
c
 c' c c<c0   c8c' 
c88c, cc
2 c<0c cc  c c
  c
c    c
c
c  
c c     c c   c 
 
c c 


 c   c %  c 0 c **&*>===7* c ,  >c
($*=(=)+c
c
1"#c+ +#c %#c+ +#c4 %#c ++#c #c(+F+#cIc&!&#c.++c cc%' c. c& c
c%& c  c cc%c c2&c"c 'c&+c +&+cB*#c75DK77*+c5GGC+c

c <,c ù c ùc   c <c c
c     c  c  
c
c $%&'c  c c 
c  
c c  
c Ô c
**(Or&/(>=/7=/$c
c
2 c #c ,
r#0,

>c c 

c 
 c 
  
c  2 c  c 
 c 
 
c c  c 
  c
   r c r>$7$)c
c
1&#c++#c!&#c +#c.#c +#c& '% #c1+#c &#c+#c ' #c4+c#/+c cc%cc
 "cc&c&cc&!3c c'c +c c+c" +c50)#c5*CK5BB+c5GGC+c
c
 !c .#c    '  c
#c &c #c &c H#c
c #c "' c +c 700*+c  c c c c  !"c !"c
'&cc! cc c 'c2 ccc  'c'+c. c  c6 9c7c7G)K*0D+c
c
 !#c.++#c &#c + +#c#c+#c c #c +#c %"#c4+ +c 'c "' #c + +c670089c : 'ccc%c. c c
c c&cc' 2c+c +c+c c1+c
+c'+c
+#c85#cB7DKB*B+cc
c
 !#c.++#c &#c + +#c   '  #c
+#c #c+#c&#cH+c 'c "' #c + +c670079c & cc. c" c! c
''c! cc c 'c 'c.
:'&'c& "cc 'c+c& +c +#c)00#c5*)K5B)+c
c
'  c<c' cc  >c c 
9c! cc$ c /Vr&>//*7/$*c
c
'  c <c    c c 
c  
c c
  c   >c

c  " c c  


c ' c  & >&/7c
,  >c&(/$)=/+c
c
 #c 4+#c ,#
+#c L #+#c<  # + +#c&&#L+#c<  #L+#c4#<++#cL&#L+4+#c.c
# + +c c +c670089c :%7:)*c 2 c
2c& c c ccc c% c&c1 5c'"+c1(c +#c7)#c758DK75DD+c
c
 #c 4+#c 4#<+#c ,#
+#c 1'#
++c 'c . #+L+c 6700*9c
#c  #c 'c    c   c ' 'c !"c )*c c
c  c%c1 5c&: %c+cc.2+#c5D#c705K75*+c
c
 #c H+#c <  #c +#c , #c
+ +#c Ic #c ++c %' c . c 'c & c c  c %c
 'c'c cc'2'& #c 'c&c!c  "c!"c : &c:'+c&c 'c +c
7G#cB)07KB)0C+c7005+c
c
 #c++c 'c!"#++c6700D9c4cccc  2c  "c%c 'c%+c  c#c8#c*D5K*C7+cc
c
 %#c ++#c
%#c ,+ +#c (=1#c +#c
2 %#c +#c Ic ,!#c + +c  c !c c  %c c
!'c 'c "ccc 'c80c" cc'+c4 c*85#c*G*K*G)+c700*+c
c
#c +#c$#c
+#c  #c$+ +#cF '>: #c(#c%#c ++#c
'2 #c(+ +#c  :
: #c1+#cc
 #c+#c#c+cc +c+cc !"ccc  c%cc670079c 7 L+c
c6c#c++9#c7G8#cG77KG7Dc
c
'  cc

c6c%  cù,c c,c'
 c<c
2 c<0c!  c#c c  c/cc6$c   c 
 c
  c c

  c 
 c/c  c&)c  
c'c
c ))>= 7*c,  >c)=&( $+c
c
%% >#c +#c&#++c 'c  # + +c670059c c c. c ''cc  cc& c&22 +c +c&%+#c
DC#c5B5K5)B+c
c
' c0c  c#0c  cc%  cc   c c   c  c 
 c  
c   c c  c &/ >)$c
,  >c)//*$/=+c
c
' cù@cù c06c@ c'c
c<c%cùc  c c
c 
c6'c  c  cc
c
 c&/
   c01# c 
 c' c &/>$/(7$=c,  >c))*//&+c
c
%#c.+#c #c+#c  #c+#cF #c+#c$#c<+#c(= #c+c 'c%#c +c670079c :''c'cc. c c 2"cc
' 2ccc c! c%' +c +c&%+#cC5#c57D*K57CB+c
c
%#cF+#c  # +#c
%#H+#c1 #+#c # +c 'c%#.+ +c65GGD9cc":''cccc
   c% cc" c. c'&!: 'c! c c c ')5c 'c ')7+c& +c +#c*CB#c70)K755+c
c
%#c4+#c4#4+#c,&'#1+ +#c.c
# ++#c
2'#(+#c
%  % #+#c1% #++#c  # +#c #+1+c c +c6700*9c4 c
& cc " c<=c"'+c4 #c*87#cBB0KBB)+c
c
%#c +H+#c$#c+#c1 '#c+#c :&!"#c4+#cIc %#c +c. c%"%" c 'cc2 'c
& c + &c*G)#cCGKG*+c5GGC+c
c
'  c6c

2cc 
c c cc0  
 c  cc&/c  
c c c


cr  c
 c,
c1c# c c4#c / > (*$7*c,  >c*) /=+c
c
%2 #c+#c '# +#c! #.+#c # +#c#+c 'c$ #F+c6700*9c  2c2cc. c! c 'c
2"cc' 2ccc 'c 'cc%& c!! c c'2c cc  +c1  "#cB#cGDK
50B+c
c
%#4+#c  '#
++#c
%#R+#c # +#c 4#
+4+#c!#+ +#c'#+<+c 'c.$%# + +c65GGG9c )*c '"c&c%c
'2ccccc 'c c%cc'"&cc  c  +c#cGD#c)7DK)*C+c
c
% #c+#c
2#c+#c1%#c+ +#c #c1+F+c 'c  #c
++c670009c:c. c cc"'c'c'c
c'c'& c& c  cc2+c+cc +#c7)8#c*0CK*5B+c
c
%%&#c+ +#c  :H  #.+#c
&#4+#c4 #+ +#c 1:
 #4+#c%&#+<+c 'c2 #++c6700)9c c
'cc)*c&cc2c 'cc22+c +c+#c*D#cD5CKD78+c
c
%%&#c+ +#c  % &#+#cF%# + +#c
 #4+1+c 'c2 #++c670089c%c %  ccc. c'  c'c
c!&cc)*:' 'c&&c&+c &#cBB*#c75BK75D+c
c
'c-.c

2cc
 c0 c cc cc  c    c  cc c 
 c
c 
 c 

 c
 c' c  c &>)(7()c,  >c) &$ +c
c
 #c
+ +#c #c +#c$ &#c+4+#cIcF#c+c  %c2"c  cc%" 'c"+c&c 'c
+c77#c7GG0K7GGD+c5GGB+c
c
'
 c 6@c   c 'c  c -<c c c '
 c   
c 

 c  c c  c c   c  c c
   c  c $/ &>/* 7c,  >c& &$((+c
c
! & %:&%"#c++#cL&#c +#c  #c4+
+#c1#c1+<+#cIc
 #c+ + c !"c6
9c c
%c cc c c+%+  c.2+c578#c50)5K50)G+c700)+c
c
>#.+c 6700)9c 'c 'c c 'c %c 2 c !"c % c 'c " c && +c c .2+#c 5G#c 500DK
5057+c
c
&#c +c Ic "#c +c %c ! c c 2c c c  c c %c  c & c %"c c
 + ' + +c5G#c**DK*BB+c5G8*+c
c
'= '' c'cF  #F+#c  #$++#c ":F  #4+#cF # +#c #$+#ccH #+#c
>#+#c #+$+c 'c #c

+$+c6700*9c c. c'  c%ccc: 'c+c &#cB78#c5GBK5GC+c


c
'= '' c'cF  #F+#c  #$++#c ":F  #4+#cF # +#c #$+#ccH #+#c
>#+#c #+$+c 'c #
+$+c
6700*9c c. c'  c%ccc: 'c+c &#cB78#c5GBK5GC+c
c
.  #c++c 'c,"#
+ +c6700B9cc' %c cc+c#c558#c70)K75G+c
c
0 c c  c<c  
c  c#,c2  c   c c 
c,
c1c# c c4cc#c ( $>((7c
,  >c($/==/+c
c
'c1# +#c '# +(+#c'c<# +#c &3 # +#c1# +1+#c 2 c
 # +#c<' #+#c 2 c 'c #++#c 2 c 4&#<+cc
+c670079c$ &c  ccc'cc. c c 'c +c
c6c#c++9#c7G8#c57D8K57DG+c
c
'c<'#c+#c.#+#c1# +#c ' #+c 'cc # +c65GG)9c 2 cc%c&c%7c c&cc %c
 c'"#c%" c #c%"! #c 'c'cc +c#cC7#c*75K**0+cc
c
."#c +4+#c$#c+c 'c"#c + +c65GG*9ccc' "cccc22c c& cc+c& +c +#c7G5#c
5B5K5B)+cc
c
.$%#c + +c670009c%c cc +c &#cB0C#c7BCK7)B+c
c
.c4 '#c +#c4#
+$+#c #,+c 'c< %#++c65GGB9c. c'  c c c 'c)*:''c5c c 'c :
c'&cc5cc c%& c!! +cc.2+#cC#c7)B0K7))5+c
c
.c#c +#cF& #+#c # +#c$#
+#c  #$+#c4&#+#c
%& #+#c #+#c&#$++cc +c670089cc
 :'&'ccc c. c'  cc 'c!"c. c%": +c &#cBBB#c8*CK8B7+c
c
.2 c#c c#c4c
+c700D+c cc 'c%c&c c   c % "+ccc4c
c8BcD)7KD8D+c
c
.#c+$+#c4#L+#c1 #+#c  #+#c
#+#c "#+#c' #++#c4#+#c &!3#+cc +c65GG)9c c! c% c
'cc%& ccc&&c 'cc  ccc22+c$+c c  '+c
+c
#cG7#cG*8*KG*8D+c
c
.#c+++#c# +#c #+4+#c &# +: +#c &'# ++c 'c3 # +c65GGD9c 'c && cc c
   cc2c!&ccc! cc'c+c +c+#c5D#cB*5KB*B+c
c
.#c+++#c
"'#<+,+#c# + +#c4% #$+ ++c 'c3 # +c670009c.c cc c& c && 'c%c
cc&c% c 'c c+c$+c c  '+c
+c
#cGD#cCB0*KCB0C+c
c
.%#c 4+ +#c 2"#+#c
 #1+4+#c  %&#+ +#c  "#+ + #c 1&# +
+c 'c 1 '"# +c 65GG79c c 'c c
)*c c'2 "c c!&c&!cc &c&&+c &#c*)8#c75)K775+c
c
. #c+#c1  #c$+#c
  #
+#c$&# +#c&'#4+c 'cF  #.+c6700B9c cc&c2c 'c. c c
  "c cc  +c  c +c 2+#c*#c5B*K5)5+c
c
.&!2 #c ++#c "#c + +#c Ic   %#c ++c &c  c& c'&'c !"c> c ' + +c
+c)#cG7KGB+c5GG*+c
c
.&&c#c> &c#c
"cF #c
Vc4#c c.#c(c4#c<!>c #c4 cc
6700C9c :  'c c "c% c'"c &c :& c'  +c
&cc+c700Cc "c5)J5D65095B5C:78+c
c
.&#$+#c 4&# ++#c . c $ # ++#c  #.+4+c 'c &%"#+c 6700*9c %c 'c D7c "%c 2  c c )*c % 2c
 '"c'c c +c +c+#c**#c*)DK*8)+c
c
#c+#c1#<++#c'#4+1+#c"#+<+#c
 # +#c
#4+#c'#+ +#c !!#++#c#++cc +c6700*9cc
&c'c2cc& cc c c &c &%:c'c  c"'+c &#cB7*#c7G*K7GC+c
c
.  "
c,c%""
c'c   ccù cc'  c'c % c-c

c!0c c 
2c   c  c  
c' c
 &/>)&&7)(c,  >c)=)  +c
c
F! #c +$+#c(%#c +#cIc #c
+c%c c c cc%& c +c +c 2+c+cD#c75K
**+c7008+c
c
F%#+Ic"#c + +c%ccc'c cc &c 'c'&'c&+& + +c5BC#cGGK50)+c
5GC)+c
c
F&#c4+#c % #c+ +#c<#c +F+#cIc
%#c
+<+c
&& c2  c%   c%c ' cc%c
'c' cc' c&'+ &++c+c5)c6&c59#c )DK 88+c7008+c
c
F#c1+ +#c
&2 #c4++#c(=#c +$+#c #c + +#c #c$++c 'c !#c + +c65GGB9c. cc%c& c
;&cc:"%"cc c% %"c' c& c  c c!c!#c%'c 'c '&c
& c;&#c c"c 'c +c& +c +#c*0C#c77*K7*5+c
c
cc
c c 
ccc cc
ccc cc
!"
c !c!c cc
  cc" #$c% c&c c'c (c)*+,(*c
---'./'-+c01c--*'cc
c
F #c+F+#c1  #c+#c$ >#c+F+#c #c
+#c
#cF+#c1  #+4+c#/+c c'c c'& c
%ccc>" c+c$+ +  '+c
+c
c507#c5080BK5080G+c700)+c
c
F  #c.+#c1  #$+#c'#.+#c&'#4+#c1 #+#c # +#c >#+#c# +#c$#4+cc +c65GGG9ccc cc
. c!' cc%c&ccc ' 'c%& c% c!'c& cc6$19+c+c+#c*B#c8B)K8)C+c
c
.
3
c c '
""
 c 0c ! c 6c , 
c c   
c c c c #c 


   c /2  c  
c
 c <c  (  c
 c
c c . c#c'   "
c
c  cc 01#c c


c
c c cÔc  >c  2 c
 cr  c 
 " c
1#0ccc c
 c#0,
  c   c
 c
c c'
c***) r>(/7(*c
c
F&c#c "c#cc#c c #c c
+c7008+c&cc 'c:c%  cc cc!"c  c 'c
!"c "c c +c%c  c.2c57DcG0)KG58+cc
c
F&#c ++#cH #c4+ +#c  :1#c,+c 'c#c++c65GGB9c.c& cc%c%c cc:"%"c
c c! cc c   c cc%& c +c  #c5)#c5B8*K5B88+c
c
% '
c c % '
c c  '  
c <c ' 
c c -c ,c .
 c <c c rc 5 c &/c  c  c  c 01#c  c
 
 c c
c  cc c
c8 c<c r>)&7)/&c
c
  : #c +#c   : #+#c  :4! # +#c  :c  ! # +#c F# ++#c , #$+#c 1 #+ +c 'c
 #+670089c
 'c)*c 2"c'cc  c:'2c  +c1(c +#cD#c)B8K))7+c
c
%  
c<#c% 3
c,c1
c0,c  c,c,c8c#c 


cc


 c c
c 
 c1#0   c
#0,
  cc   c    c c 
 c c01#c  c c

c  c8
c<c />&=&7)c
,  >c$&**=+c
c
"# +c 'c  %  #
+c6700)9c  c%ccc)*cc  +c  c#cB#c5)DK580+c
c
% 6  c?c
 c<c  cc cc 
 c

c
c  c 

 c 
ccc c
 
c
 c
 ,%'c8
c<c ()>*/7/c,  >c(/$()$=+c
c
%
 c#c-
c< c8 2cc,  
c<<c c<c!c68cù  c c  c c  c  c    
c
c c   c
cc
 cc2  c%  c0 c**) r(>=/)7=& c
c
"#c++#c #cH+#c$ #c +<+#c4#c.+#c, #c
+ +#c,>#c.+c#/+c& c  "cc. c'c
& cc''c c&c!cc 'c%&c"+c  cc*#c*5GK*78+c700B+c
c
!&2 #c+c 'c42"#c + +c65GGD9c% &c. c'c3 cc ccc  'c%c'c 'cc. c
+c&c 'c +#c7)#cB8)0KB8)D+c
c
!&2 #c+c 'c
& 2# +c6700)9c  c'ccc'c c.
1c c 'c  +c%+c  c.2+#c578#c875K87C+c
c
&  #c.+#c '#cF+#c #c+#c#c+
+#c% #c+
+c 'c%#c1+ +c670009c% c 'c cc%c c
 'c' cc. c c  "+cF
1c +#c5B#c5*7)K5**B+c
c
#c.+ +c 'c%&# ++c670089c)*c 'c !c'c%c +c#c578#c*0K*7+c
c
% c 8c  c #c .c   
c  
c c  c   c  c 
  c c 
c  
c 
 c
 &$>($ 7&c,  >c)====+c
c
#c
+ +#c #+#c,&  # +#c&#.+ +c 'c"# + +c65GG79cc22c%& c c& c;&"c 'c&c
%c +c& +c +#c788#c5CGK5G8+c
c
 #c4+c 'c<#R+c65GG)9c. c c 'c' "cc!  cc  +c+c%+#cB5#c5C)BK5C8*+c
c
%cùc
 c%c#  
c
c&/c     c01#c   c c 
c
c c&/c'  c
 c$rrc**( r$>&*&7) )c
c
& c4#c$ 'cF+c700)+c cP%c
 7c+cc570cBD*KBC7+c
c
& c4+c7000+c
7cc% c #c !#c 'c  +ccöc.2c5Bc5075K5078+c
c
&&#c +#c   #L+#c
2 &  #+#c .c 4& # +#c ' # +#c  #1+c 'c 4! #.+ +c 65GG)9c .c c %c
c  cc)*:' 'c5c %c c 'c c! c)*:'&'c c& c5c +c1'#cC)#c
78G5K78GC+c
c
&c H#c "' c #c % 'c +c 5GGC+c &'c c  c c 2"c  !'c 2&c  !'c . c c  c
% "ccc c 'c' "c+ccc c7B)c77CK7*C+c
c
&#cH+#c "' #c +c 'c % '#c +c65GGC9c&'cc cc 2"c !'c2&c !'c. cc cc
% "ccc c 'c' "c+c+cc +#c7B)#c77CK7*C+c
c
6 c'c

2cc6 c-c cc$c  c% c0 
 cc c  
c c,   c
c' c' c ))>*$7&$c,  >c)*&*&(/+c
c
#c+4+#c c # +#c. # + +#c  # +#c&#H++#c,#,+#c< #+ +c 'c % '# +c670059c.c' 2c
'  cc. c c%c @c$+c c  '+c
+c
#cGC#c50B8GK50BDB+c
c
  #c$++c670079c
&!: % "cc&'cc c 'c%c & +c( #c75#cCGBGKCG)8+c
c
&'#c +#c
#c (+ +# #c ++#c Ic  #c ++c  :c %& c 4:5c '&c
cc cc%c c)*+c +c1'+c1%+c700B#c5C)K5GB+c700B+c
c
6 cc   c#<c c&/c>c
   cc   c   2c

cã c &Or(>=**7* =c


c
#c +<+c 'c
#c +1+c65GD89c. c cc :  c%& c+c%+c  c.2+#c)#c8DKDD+c
c
6cc8#
 c1c6 c4c cc# 
c  c c01#c    c   c
c01#c
  c c

 c c  >/7c,  >c$&/$(+c
c
6c ,c '  c <c 6
32 c <c c  c 6c ! 3 c <c #  c c 
 c    >c  
c 
c  c 
 9c Ô c
 /O r&)>/&&7/&*c
c
' "#c+c6700*9c$ % "ccc% &c! cc   c+c& +c +#c)*7#c50*K55)+c
c
#c,+c 'c
 #c+c670079c c c c:'c 'cc%& cc. cc&@c +c2+cc +c55G#c8GGJc
'&cD00K8G7+c
c
! #c+#cF #+#c'#4+#c "#.+c 'c
'2"# ++c670089c& ccc  c +c
c6c#c
++9#c*55#c57)D+c
c
"' c #c % c #c 4&c 4#c % 'c +c 700D+c  c c 'c c  !"+c &c 'c c *)c
DBC)KDBG8+c
c
#c +c 'c1%#
+c6700*9c  cc' 'c!"c%c)*c&&c&+cc. %c.+#c50#cB0BKB0C+c
c
' "#c +& c 'c& cc   c+& + +c7)0#c*)5K*8*+c5GG5+c
c
6
 c%c
 c# c   c-c "c8c cc c@c 
 c<c6   
c
c c    c
 c cc
 /c  c 


 c
c%   c**($&>) &7$c,  >c* && (+c
c
6
"   cc0
c<c0
c c   c,c% 
c#c8 c,'cc rc%.c 
c  c  cc   c
c
   c c c
 c1 c /$r)**>=7=(c
c
6
 "c -c  c -<c '
 c 6@c c c c 
  c   
c
c   c  c  
 c     c   c
1 c /$&>*7)c,  >c*/*)(+c
c
  #c + +#cF&#c4+#c 2 #c++#c4#c+4+#c. %#c$+,+#cR#c+c#/+c.cc  : c2  cc
%c%& c + +c+c*8#cGBGKG)5+c700Bc
c
 c c #
 c 'c -  c c %  c c   
c     c c 
  c 
 c  c c c 1#0   c  
 c
   c! c Vr)((>(*&7= c
c
 #c
+H+#c,  % #c1+#c  &#c1+ +#c
&> :$#c++c 'c1%#c+ +c670089c%' c 'c& c. : c  "cc
2 &c! c cc&cc 'cc c :''c +c&c!+c  #c7D#c557GK55*8+c
c
 #c+<+#c%#c+ +#c % #c+ +c 'c< #c+ +c6700*9c : 'c! cc c 2"cc&c! c 'c2c
& c +c +c+c c1+c
+c'+c
+#c)C#c70)K755+c
c
 #c+<+#c % #c+ +#c "#c + +#c< #c +1+#c, #c ++#c &#c+#c #c+ +#c%#c.+ +c 'c
< #c+ +c670079c1 cc cc'c!"c'ccc c cc& c c 'ccc"& c 'c
'c+c+c+c1+#c77#c7B50K7B5C+c
c
 c1c
"2
c,c8 cc,



cc! 
c%c ccc rcc
  c#c c
c&/c 
2c&/760c   
c
c   c&/c 
c c
c1c c $ r>/7/=c
c
  #c +#c(%" %#c,+#c(%" %#c + +#c " %#c
+#c %  #c+#c '#c,+c#/+cc %c 'c c
2"c2 "c%c cc% c!'cc! 'cc c'2'& +c &+c+c507#c*GDKB07+c5GGC+c
c
#c
+$+c670079c
 c 'c  c. c'&!: 'c! +c  #c7*#c8CDK8G8+cc
c
>#c +#c F# +#c F # ++#c
#+#c <  #++#c .!#.++#c % #+#c .$%# + +#c
% #++c c +c
670089c
:c  c''c!"c%c":''c c%!c58,B +c &#cBB*#cB75KB78+c
c
"#c + +#& #c +#c Ic <#+c  c &c ;&c 2  c c  c c 2c &c c . c
"%cc&'" c2  c 'c& c!"c c&c  "+cc80#cBD*KBC)+c5GG0+c
c
"   #c ++#cF #+#c
'2"# ++c 'c ! #+c6700D9c && cccccc&cc  c +c
%+c  c.2+#c57C#c*8KBB+c
c
  #c +c 'c
 # +c 670089c &c c . c '  c %c c c '  c c  !'c 'c  !'c
;&+c+c+c1+#c78#c*GKBG+c
c
%#c +.+c 'c #+c670059c.&!: ':! :'&'c% &c! cc   c+c1%+c
+c
 +#c7G#c5G8K705+c
c
%#++# '#c
+#&  #c
+#c'c #c+#c'c #c
+ +#"#c +c#/+c4 2"c c +c
%+ !+.+c7)#c5GDK708+c7007+c
c
#c++#c% #c+1+#c&#c1+#c%#c+4+#c$% 2#c$+#c!2 #c+c 'c#c.+ +cc65GG)9c cc c 'c
2cc c& c c%c%c ccc"%"cc%& +c& +c +#c**C#c57GK5*G+c
c
#c
++#c # ++#c.%#4+ +c 'c1 '"# +c65GG)9c &cc!"c% "cc'7:'cc!"c !cc
)*+c &#c*DC#c708K70C+c
c
&#c+ +#c4#,+ +#c$ # ++#c#+
+#c&#++#c #+ +#c,#+ +#c%# ++#c #+ +cc +c670089c. 'ccc
. c cc,&D0c 'c55cc  'c%c  c 'c "c!&cc%c& c+c+c+c'+#c*C#c
8C8K8G*+c
c
-  cc# c##c "c% c. 2c%c%  cc 
 c     c0!c
 c
  c cc 
   c  c%   c $))>))7(c,  >c&)/==+c
c
-  cc ! cc%  cc c / $c
 ccc
 c

 c
  c c 
 c     c c

c   c  c%  c0 c***/>&( 7= c,  >c &$ +c
c
, & #c+
+cc 'c  + !' c2"c$#c#c5GGB+c
c
,  #c$+c65GG89c c !"c 'c. c %c cc%& c +c
+c c1+#cD#c5)K7B+c
c
,'"c1,#c
c,,#c, !c+c700D+c & cc' "cc 'c  +ccc4c
c8Bc5*7*K5*7C+c
c
-  cùcùc@c!
c6c%
cc
 cùc c##c)/c   c   cc
 c
c c    cc c
c   c
  c%  c0 c &*r(>*=)7***c
c
,% #c,+#c1'" #c+#c%"#c<++#c2 c(&#c+ +#cH%  #cL+#c#c + +c#/+c:!":c  cc%c
%' c c c 'c %& c % c 2 c c   c  c c ""c %c  "c  ''c
'+&c 'c +c7D#c7B*BK7BB5+c5GGG+c
c
- c 0c 1  c 0c 0
c c c c c    c 
 c   c  
  
c c 
 c 
c #"  c
   cc

 c c  
 c8
c<c ()>/)*7(*c,  >c(&=)/(+c
c
,! '#c +4+#c .2"#c +#c $% #c +#c
% %#c +#c 1 #c <+#c Ic , > > #c + +#c +c F&: %c %& c 45c
c c%c  "cc% %c;&"c cc&&'c+c &+c+c+cC#c5))DK5)80+c
5GGG+c
c
, !&"#c+ +#cF' #c1+#c#c+ +#c %#c
+,+#c  #c + +#c, &% #c.+c#/+c &'c&c c
& "c 2c 'c  'cc! c&"+c$+c +c  '+c
+c
c507#c85B*K85BD+c700)+c
c
,%#c
+c6700B9cF& c  c 'c  '& ccc>! %+c +cc  '+c
+#c505G#c)75K)78+c
c
,%#c
+<+#c$2#c+
+#cF#c +#c,>#c$+4+#c1&#c<+(+#c
 #c + +#c$& #c.+4+c 'c
%#c ++c65GG59c
 cc
 &c 'c& :'&'c& cc%c4 c cc  c+c$+c c  '+c
+c
#cCC#cDG)CKDG87+cc
c
, 2 #c + +#c,' 2# ++#c<  #,+#c%2#,+#c2 #++#c'!&# + +c 'c&'2# ++c6700B9c.& c c c)*c
c ' c2"cc22c)*cc% c3&"#c!&ccc : c"'cc+c( #c
7*#c*78)K*7D5+c
c
, "! #c+#c,&'" 22 #c+#c,#c ++#c& #c+#c, #c+<+#cIc,% #c,+c%' c. c'c
c !&' c 'c &c& c cc 'c%& c&!  c  c&+c +c+c*C#c)5CK)70+c
7008+c
c
,%2"c
+c$ #c+#c& #c +#c#c +1+#c!# +#c%&' #c.+1+c 'c%&' #c +1+c6700B9c c 'c c
 !"ccccc% %"c'2'& +c+c+#c*G#c)0DK)5)+c
c
,% #c+ +#c % #c
+#c
&'%  #c +#c
& #c +#c, &#c +c 'c #c,+
+c6700)9c '&'c. c c cc  c c
& c c 'cc c!"c. c" c! c 'c. : +c +c&%+#cG7#cC5CKC7*+cc
c
- c<c
 c'c cc -
 c%c #  c -c ccc rc2$ #c  
c cc
2 c
c  cc$r cc
 $r*>**7/ (c
c
,#c++ c 'c%& c' +c
c78G#c58C7K58C*+c5GG)+c
c
-
 c #c ,  
c c 
2 c c 0  "c ,@c '  c <c    c  
c 

 c    c c 
c c 
   >c c  2c
 c  cc  c c! rc' cÔ c(Ô'c  r> (7 ((c
c
,&#c$+ +#c #c+ +c 'c1%#c+ +c65GG)9c. c'  c 'c ccc cc  +c$+c c  '+c
+c
#c
G7#c7)CK787+c
c
,&:#+c670059c. c'c%& c  +c'c+c'+#cD#c5DGK5C5+c
c

 c c # c 'c % 6  c ?c c c   
c 
 c  

 c  
c c 
 c   c  
 c
   c c    ccc,%'c' c )(> *7c,  >c(&()+c
c
  c 0ùc 
 8  c c    2c c c c 6c    c     c   c  
c c 
 c
  
c  c &/ *>=)7$c,  >c) &(&+c
c
  c8c, 
cc. cc cc6cc   c&/cc
 " c, &/c  c c    c
8
c<c >/=/7*)c,  >c )$*+c
c
4 '#c$++#c'#c+$+#c2 c'c 3#cF++#c.  #c+#c4#c++#c.#c +<+c#/+c  "cc
c %cc%& c%+ &++c+c)#c8C)K8G5+c5GG8+c
c
4 #c +1+#c &#c +#c Ic &#c 4+ +c & c 'c %' c . c  c  c  % "@c
%'c)#cCGK50C+c700)+c
c
4 #c.+#c 2#<+c 'c'3'#+c65GG59c4cc& c%>" "cc%& c +c &+c 2+c+#c7)#c
7C5K*5B+cc
c
4 2#c+F+c 'c&2#c+c670089c%c"cc)*c !> c 'c 2 +cc. %c.+#c5*#cGB5KG)0+cc
c
 cc8c, c.cc<c6 c<8c
 c
c cc  cc  c c c    c01#c
  c  2c
cc




cc




c  cc'c
c****>()(7( c,  >c $&=+c
c
  c 8c @ c c <  c -c c c  c  c    c 
 c  c   2 c 
c  
c    c c c
c c#  c0 c &)> *(7 &c,  >c&*)$ ) +c
c
4 &#c +#c ,>#c ,+<+#c Ic  #c 1+c . c %" c 'c c  !"c c  c  c +c
$+ +  '+c
+c
cGB#c7)B)K7))0+c5GGD+c
c
4!#c+ +c65GGG9c%c!%"c 'c!  c  cc% &c. c'c3 c c c ccc
&& c& "+cc#cB#cDDKC)+c
c
4!#+ +#c #+#c$ #+c 'c
% >#,+c6700*9c% c 'c & cc%& c:% &c. c'3 +c
 +c 2+c+cc1+#cB#cD57KD70+c
c
4#.+
+#c # +#c<'#.++#c
'# ++#c$ #,+ +c 'c "#$+c670009c  "cc&C0:& cc 'cc%'c
2cc)*+c+c+c1+#c70#c*DD7K*DC0+cc
c
 c <c 0 
 "c ,#c %  c c     c
c 1#0c c c 
c   c  
c c 
 c   
c c Ô   c   )c
Ô c***+,-.,/012,)c
c
4&#c .+c 'c !"#c $+ +c 6700D9c
c %& c !! c  c %c  "c %c c   c &c 2 c  c
  c+c c +#c8D#c*55DK*578+c
c
4&#c 4+#<"#c ++# '#c 4++#c Ic !#c +(+  #c  c 'c &c %c . c %" c
+%+  c.2+c57B#cGCGKGGC+c700*+c
c
4&#1+#c <  # +#c % #,++#c 3 #<++#c . #<+#c & #L+#c &  # +.+#c 4#,++#c % &#$++c c +c 6700)9c c  !"c c
  %":! 'c &c  +c +c'+#c55#cDC0KDC)+c
c


c!0c-  c -c  c c  cc   c   c' c ))>&(7)=c,  >c)=(/ &*+cc
c
4#c +c 'c
%#4+c65GG*9c  cccc'cc':"c)*c cc cc'&cc c
!"cc +c1'#cC7#c50G7K50G8+c
c

 cùc'  
c8c8c%c  c
c 
c! c $VOr( &>/ (7/&c
c
4#c
+<+#c
%#++#c
%#
+<+#c(!#1+ +c 'c #+c65GG*9c)*cc;&'cc ' :'&'c cc&c
%""+c &#c*87#cCBDKCBG+c
c
4&#c+#c$ #c+#c, c#
++#c4#c+#c,% #c+#c% #c +c 'c #c1+ +c6700B9cc & c 'c. c'  cc%c  c
%& c! +c &#cB7G#cCC*KCG5+c
c
  c#c6cù'c%c,cù   c#c%  c 
 c c    cc 
 "
c$cã c$rrc rc Or)>( &7( *c

c <c 1 2
 c #@c  c c ' c 0c c .c  
c #c c rc 1   c

c
c &/c c  c 

 c c  c  c  c ' c
  (r>/(7$=c
c

c<c1 2
 c#@c cc cc1   c

c
c&/c c c

 c c c c c' c  (>/(7
$=c,  >c)(&+c
c
4&#c+#c
#++#c. #4+.+#c%3 #+#c#+#c&& # +#c # +#c
%&># + +c 'c1 '"# +c670009c c
'c &'c!"c2 'cc! cc1c+c +c+#c78#cB7BKB7G+c
c
" cc'

  cc0 c.
 c ,,c,  c ,%c8

c
c c  
c 
c  
 c
cc$cã cc#c***+*.1011,2
1/)c
c
 c<#c
 'c4 #c4c.#c4&c #c4cL#c c#c4&c+c700D+c$A.1$5#c c%KK%c#c&c& +c c
c1%c500c5*D8K5*C8+c
c
c1c  c-c0 ."
c%c
"2 c0,c' c   cc  2
c 
c
c 
 c6/c-&)c 
c c6/c
c6$c
 c c )/> *7*c,  >c)==/&+c
c
 cc c% cùc  c c cc
c-c%  ccc rc

c
c c  cc c c
c 

c
c&/c%  c
0 c $=r/>/ )7/*c
c
 #c.+#c4#F+$+#c
 #4++#cF &# +F+ #c#++#c,#.+ +#c, # +#c" #+ +#c1%#F+H+cc +c65GG09ccc
)*c& cc c  c"'cc! c #c  #c 'c%c +c
c6c#c++9#c7)0#c57**K57*C+c
 #cF+ +#c &:4#+F+c 'cF!"#+c6700D9c%c. c'  c   c % "cc c c' cc
 '&'c+cc.2+#c75#cB*KBC+c
c
 #c .+1+#c
 #.+4+#c Ic
'#c + +. c '  c  c c %c  !"c c &c c c
''cc'  c"+c$+ +  '+c
+c
cGB#c775)K7770+c5GGD+c
c
 %#c+.+#cH  #c +c 'c#c++c670009c. %c  c'&'c > cc)*ccc%' +c c cc
c c   +c +c1+c%+#c7D)#c58707K58757+c
c
 #cF+#c '#+#c   #+#c&>>#+#c
 #+#c$2 #$+c 'cF #++c670089c. c&'cc :
''c   cc%c 2 +c$+c c  '+c
+c
#c50*#c5D*7)K5D**0+c
c
 #c +#c< # +c 'c. #+c6700)9c." c  c #cc 'c  +c&+c(+c+c.2+#c
5)#c7BGK7)D+c
c
 c%c
 cc2c1c% cc% cc 
 "
c
c 
  c-ccc
 c c 
 c
c01#c
c  2c c c' c****(>)7//c,  >c /)(=*+c
c
 #c++#c
%# ++#c,#.+ +#c( !&#++c 'cc.%#++c65GC)9c 'c% c ! ccc
 % ccc 'cc%c'"cc 'c+c+c +c'+c
+#c75#c7G8K*05+c
c
 : &>#c++#&#c +#c2 c #.+#c2cH #+#Ic<'#c ++c %cc%c!'c
ccc  'c%c!'"cc "cc%c'c'c c& :! 'c&'"+  ccB#c7CDK7G0+c
700)+c
c
 c +c5GGC+c c 'c%c   c cc' "c+ccc**c85K88+c
c
 c +c700)+c(22cc cc 'c  +c%c  c.2c578cG5*KG77+c
c
 %&# +#c   2# +#c , #$+#c F#+#c   : #+#c 1 #+#c F# ++#c  # +#c 1 #+ +c c +c 6700D9c . "'c  c
%& %c'  cc!"c%c A)*c % "+c &#cBBC#c*D)K*DG+c
c
 ! #c
+#c,  # ++#c$ #<+.+#c< # +#c1%#+#c 22 #(+#c &"#$+ +#c1&>#F+c 'c   #$++c670089c)*c & c
%' c +c
c6c#c++9#c*57#c58)0K58)*+c
c
 "#c$+ +#c4  #c+
+#c1 '"#c+(+c 'c%#c<+<+c65GCG9c :''c'cc3 ccL: ":'&'c. c
'&! 'c! cc c%& c"%"+c& +c +#c75G#cG)K500+cc
c
  cùc@ cc<  c-c cc c cc
 ccc
 c c  
  cc  
  c

c' c
c //>/=7&$c,  >c$=*&*+c
c
#c +#c,#<+#c
'%&#+#c  #,++#c#$+#c
%'#1++c 'c  #$+F+c6700*9cccc c'"cc
22c c%c %c 'c c'c ccc% +c,'"c+#c8*#c75*BK75B*+c
c
 cc c-#c 8 c-c 
2 c<c8  c1c,
 c0#cc rc
c 
cc
c  c c c c

   c c&/c   cc#c )Or>)7c
c
'" #c
++#c (=4 "#,+ +#c #+,+#c % # +#c  # ++#c $#.+ +c 'c $"#++c 670089c &c
&c 'c c  ccc%c&2"c% %c)*c 2"+cc.2+#c70#c58K75+c
c
'" #
++c 'c$"#++c670089c&c&c!"c)*c%&c  'c  c3&c& %cc c 'c% @cc"c
6 #c+9#c)#cD5BKD5D+c
c
 #c1+ +#c  #c +#cIc1 #c + +ccc  cc 2 cc%c%& cL:'c $ c&+ &c
**)#cG*KG8+c5GCC+c
c
  
c8c%

cc  cc,  c%c
 c,c,
 c,,cc rc c)) c
c
 c

c
   c c 
 cc  c
c cc1 c***$ r)(&*>/ *7//c
c
 c-0c   c0#c%  cc8'   c   
c
c c /c    c
 c
c 
  c
c01#c
  
c  2c' c****(>) *7 c,  >c /)(=* +c
c

" c 0c 8" c     c
c  c c 
 c     c ' c
 
c c c

c  />/7=c ,  >c
$=&&=+c
c
"#c ++#c
&"#
++#c %#++#c #
+#c$ ' # +#c,% &%"# +#c
% #++c 'c#
+ +c670089c  cc
58,B cc' c! c c 'c& c'& c  +c &#cBB*#cBBCKB)7+c
c
#.++ c!cc'c'+%+  c.2+c578#c50B8K50)0+c700)+c
c
c'c( c4& # +#c< #.+
+c 'c4> #+c65GG)9c &cc "c!"c% "cc'7:'cc!"c'c
c)*+c &#c*DC#c70*K708+c
c
#c+#c  #c+#c #c+#c & #c+#c%  #c+c 'c '#c(+c65GG59c
& &c !%cc c
!'ccc%c"!& c"'c'cc68:B9c%'&cc%c c&c&>'c%c& 2c
 ' 'c. +c$%%+c$%!+c)B#c77)K7*7+c
c
 #c
+:+#c "#c
+#c #c ++#c, #c,+ +c 'c #c4+c65GG89c%ccc'c cc%c cc:
'  'c. c!"c&&'c%& cc'&'c. c c  "c 'c 'c& !"+c& +c +#c*8B#c55DK57*+c
c
"#c +c65GGC9c
 c& c 'c  +c +c+c+c  '+c
+#cC)B#c70K77+c
c
"#c + +#c#c
+c 'c ' "#c +c65GC79c & c"%"c cc8:% & c c%c +c%+c  c.2+#c
5G#c75K78+c


2c c 'c -.c 
 c 0 c c c % 
 c   c c    2 c  
 c c  c    c
c  c
)c' c )$>/&7*c,  >c)$/* )+c
c

 c-#c% c##c, cc cc   c
 c
c c c c   c c c  c 
 
  c  c  
c c c' c  c &> &7(c,  >c) *===+c
c
&%"#c++#c4&# ++c 'c #.+4+c6700B9c)*c2cc%' c c&cc%c %cc +cc"c6 #c
+9#c*#cC*8KC*G+c
c
12cc,  c<%cù   
ccù c6c#c

 c  c c c    
c  c cc c ccc c  c
rrr)c c! rc' cÔ c(Ô'c--+-.01211)c
c
% 2 #c +#c 1'" #c +.+#c , "! #c +#c  %#c
+1+#c  c (&#c + +#c $&>%2#c +c # /+c  "c
 ''c. cc& c c !&' cc'2'& ccc%& c&+c$+c +  '+c
+c
cGG#cc
))75K))78+c7007+c
c
#c
+#c '#c +#cF %#c +#c(2#cF+#cF %#c+#c 2  c#c+c 'c  #c+c6700)9c %c c"c 'c
 c c !"cc% c!'ccc'"c 'c  +c +c+c c1+c
+c'+c+#c80#c7C)K
7G7+c
c
1 2
 c#@c cc,2c1cA c<c%cùc, >cc 
 c 
c
c&/c$rrc /Or>*7$ c
c
1  c6c cc!  c#c01#c  c  
c  c
c c   c c
  c 

 c
 c  c8
c<c
 >&*$/7&c,  >c$&+c
c
(#c+c6700*9c.c  c!"c)*c#c' %c 'c +cc. %c.+#c50#cB*5KBB7+c
c
(#c,++#c4#+#c,'#+c 'c,#$+ +c670089c
2c&> cc% &c':3 c 'c
% &! c. c c % "c'& c2&c"c'2+c$+c c  '+c
+c
#c50*#c5005DK
50077+c
c
('#.+.+#c13#
++#c"!3  : # +c 'c' '#1++c6700D9c&c&c)*c  D7$c"%c 'c
 2"#c c&22 #c 'ccc cc%c  c& +c +c+c'+#c70B#c57G)K5*05+c
c
$ #c +1+#c #c ++c 'c& #c1+ +c65GD*9c4c& 2:c'&'c c cc  c''c%& cc6<:
*C9+c ' +cc +#c)8#c)80K)8B+c
c
$ #c
+#c #c +$+#c , #c +c 'c  #c +c 6700)9c
 :% c  c c  c 'c  c c
!! c c% cc  c+c c +#c8D#c*55DK*578+' +c +cc
+#c55C#cBC)KBG8+c
c
$' #c ++#c H%&#H+#c  ' # +#c F3# ++#c <  # +#c &!"#,+#c &'# +#c <# +#c ' &>#F+c c +c 670079c
.2c c c c 'c&& c 'c '"c  ccH7Bc  :'c+c +c+#c
*5#cGBKGG+c
c
, c.c- cc' c1c cc c

 cc
 "
c c  c 
 c c    c,,# c1 c
 $$*>((7)c,  >c&(&()+c
c
$&;&#c(+c 'c  &#$+c670059cc 'c: c % "cc)*c'&+c c4+#c5DB#c5K5)+c
c
$#c+ +#cF#c+c 'c #c<+ +c670089c :''c& cc'&!: ':! c c % "+c&+c1+#c58#c
700GK705)+cc
c
, c -c ? c c c <8c c c  
c
c c     c    c  c  c  
c 
c
c 

 c 01#c
  
c,
c%  c )> $ c,  >c)&*)))+c
c
"#c+ +#c#.+ +#c1# +F+#c4#.+ +#c(#4+ +#c
# + +c 'c&# +.+c65GG)9c%ccc c 'c"c
 cc%c && cc" c'  c c &'c!"c%c  +c& +c +#c**C#cG)K508+c
c
"#c+ +##c.+ +#c7'#c1#c +F+#c4#c.+ +#c(#c4+#c
#c + +c#/+c%ccc c 'c"c
 cc%c && cc" c'  c c &'c!"c%c  +c& + +c**C#cG)K508+c
5GG)+c
c

 2 c8#c,3cc6 c-c 2c c@   c-c 2c0c&/c
 c cc c c1)/c 
cc
 c 
c
c c! rc' cÔ c(Ô'c  r$>=(7=c
c
%#c
+,+#c #c + +#c , &% #c .+#c , !&"#c + +#c   #c + +#c Ic %&#c +c % c 2  c c
&cc%c'2 c 'c '&c   c2&c"+c$+ +  '+c
+
cGC#c5**85K5**88+c7005+c
c
%#c
+,+#c& #c++#c %#c+$+#c, &% #c.+#c  #c + +#c ' #c1+
+c#/+c& c &'"cc
%c c%& c! +c +&+c7)#c75D8K75C0+c700)+c
c
#c,+c 'c'c(>#c
+$+c670079c:% &c. c'c3 cc%c &c c! +c +c&%+#cC0#cGBGKG)G+c
"'#c1+ +cIc >#c +4+c& ccc 'c&%P:2 &  c%c %+c +c%'c7#c
***K**8+c700)+c
c
% '#c1+c cc  cc. c%" +  c + 2+c7#c7B)K785+c700*+c
c
 
cc c8c "  c1c c   %.c   c ccc c   c
cc
  c8c% 

c
 &$ >=(/7(c,  >c))=) +c
c
 % &#c +#c (=
% #++#c F%# + +#c
 #4+1+c 'c 2 #++c 670089c '7c c  "c 'c &&"c ;&'c c
&c% c)*c 2"cc22+c c#c50#c)05K)5B+c
c

 c <c   c 'c 6c ùc % c ,c  c c ,   c ,c 1 c

c
c 
 c 

 c 
 c c

 c
c,%'ccc1 c &$/$>/7=c,  >c&($$/ +cc
c
'#F+#c ,#
+ +#c 33 #+#c  #$+c 'c  # +c 6700)9c  c 'c  c %c  c c c c c
  +cc +c1%+cc1+#c*D#cGDDKGG0+c
c

c c6 cc c   c
  c c cc
 ccc  c
c 
 c  
c,
c1c# c c4cc
#c $ >&**=7) /c,  >c&& /=$+c
c
#c.+ +#c1"'#.+#c
 # +#c&> # +#c 3 # +c 'c< #+4+c6700D9c.cc. c'  c cc
%c&cc%  ccc%c +c &#cBBD#cD7)KD7G+c
c
 #c +#c F &#c 1+#c %#c +#c   #c +#c  > #c +$+#c Ic 4#c +c %' c %%'c +c
1%+c +c*D0#cD)5KD87+c700*+c
c
% #c,+#c,& #c+#c%#c4+ +c 'c4!%#c+c6c700*9c$ % "cc. c'&!: 'c! c c'& c%c
   cc"+c+c+c1+#c7*#c)D08K)D5)+cc
c
&'%#,+4+#c %  #
+#c 4# +<+#c 1 #+#c !#+ +#c '#+c 'c .$%# + +c 65GGG9c 4 2"#c c #c 'c
 cc  c :'c+c#cG8#cD05KD57+c
c
&"#c ++#c 4#
+<+#c #+c 'c & #.++c 65GG*9c )*:''c c '& c %c ""c c  c
+c#cDB#cG)DKG8D+c
c

! #c + +#c 1&' 2# ++#c" " #++#c 2 #4+


+#c , 2%# ++c 'c%& 2#$++c6700)9c%c ' c&c
c%c)*c&c&+c +c'+#c55#c5*08K5*5*+c
c

%:% #c+c 'c ' "#c+c6700B9c2 2c% &c! c "c c. c'&!: 'c! c
c%c
c% cc%cc"cc%& c+c&c 'c +#c*7#c*8C*K*8CC+c
c

 #c ++#c1  #+ +c 'c<# + +c65GGD9c  cc:c'&!: 'c! cc   c%c!"c
% &c 'c  c! +c+c+c1+#c5D#c78DK7DD+cc
c

&'c4 #c'c+c700D+c
&c c & c c%c 'c!c c 'c  +c( c78c)BCGK))0B+c
c

 '#$+c 'c#+c670089c4 c :''c& c'cc%& c  +c


c6c#c++9#c*57#c50)GK508*+c
c

! #c +#c4 %#c1+#c #c +#c  '#c +#c& #c +#c4&'#c$+c#/+c4  : c"c&!c"%c
c%c%& c +c
c*0)#c)7)K)7C+c700B+c
c

'2 #c(+ +#c   #+#cH3#.+1+#c$&#++#c1#<++c 'c1 # ++c6700B9c


 c%& cc 'c
 cc && c. cc%c&  !c'&! 'c! +c +cc1+#c8#c58CK5D0+c
c

& 2#c +#c #.+#c$ :


%#(++#c<# + +c 'c!&2 #+c6700B9c. c'c3 c!ccc 'c
c:c'& c& c+c$+c c  '+c
+c
#c505#cD87BKD87G+c
c

& 2# +#c. # +#c &#+c 'c!&2 #+c6700D9c%  cc%c2c 'c'!&cc,&cc'& c& c
+c. c  +cc
c

% '#c.+ +c670089c. c'c3 c 2"cc'&'cc >%=c' +c&!+c  #c7D#c)G8K80)+c


c

% #c+#c
 !#$+ +c 'c%'# + +c670059cc! cc&'c!"c% c'2 cc%"!'ccc
' "c 'c&c +c +c+#c7C#c58GK5D7+c
c

%#c+$+#c #c +#c&#c+c 'c<  #c


+
+c6700*9c.cc& c 'c%' c' 2c! cc c
2"cc c  c%& c''c!! +c. c  c6 9#c7#c8D*K8G*+c
c
 c c ù c .c   c 8c 
 c Ac /c c  

 c   c    c   c  

 c  
c c
 
  c c 
c 
 c c<
c
c

c   c &= >/&) 7(c,  >c&)&/)= +c
c
   c 0#c %  c c 8 


c 01#c   c  c
c   c c  c ' c **(*> //7$c ,  >c
*$=&&+c
c

 %#c+$+#c. #c.+1+#c#c + +#c1 #c4+c 'c


%'#c+4+c65GG09c. c'  c 'c c%c cc'2'& c%& c
"%"+c& +c +#c7*D#c57*K5*0+c
c
c

 %#c+$+#c( !&#++#c<#+
+#c2 c1#+c 'c #++c670059c. c'&!: 'c! cc&c'"cc%c
+c1  "#c7#c785K7D0+c
c

#c ++c 'c&#c+


+c6700)9c(' 2c& #c %c #c 'c  +c
+c  c,' c2+#c700)#c
*+c
c

 !#c$++#c'c4&#<+ +#cIc3 #c +c c  c2c 'c%" c cc $. c 'c! : c
cc c2#cc 'c! cc cc  +%+c  c.2+c)*#c7B*K7)D+c5GG0+c
c

ccù  cc   c c 
 c  
cc  c  c**)(/>&*7)/c,  >c=)&=*)+c
c

 cc ,
 2c1c4cc
 2 c8c1 2 c c0
 
 ccc rc01)/c
   
c  c
 
c
c c
cc   c  c 
 c c c
 c' c'  c )&r(> &7 c
c

' #c +#c % # +#c


!# +#c   &%#+c 'c  ' #
+c 670089c . c & c c :% &c ':3 c 'c
% &c! cc'&!c 'c! c +c. c  c6 9#c)#c5075K507G+c
c

 #+<+# #.+ +# #c+#cIc %#c+ cc cc c%' c. c& c
c '&c%& c! + +c+c7#c*5CK*7*+c5GG7+c
c

2  2 c ,#c c


#c
%'c .#c c <#c 1&!c .+c 5GG*+c : 'c %  c c c 'c 2"c c . c
" c c
ccc' "c+c& c c7G)c78)K7C0+c
c

 c!c , 
c0cc0c c@c
c c< c@cc rc 
c
c !c  
c c cc rc$rrc r>/(7/&c
c

 #c ++c 'c #+c6700*9c2ccc%>" "cc&'c'& c% &c cc% c! +c
+c+c1+#c7*#cD**KDB*+cc
c

%#c1+4+cc !"c c%c "c &cc%& c  +c++c75#c7C*K*5G+c5GC8+c


c

& c #c ,  % c 1#c  &c 1 #c


&> :$c #c 1%c  +c 700B+c %' c 'c & c . c ! c c  c c
'c'"c!"c c+cF
1c c5Cc)G)Kc)GD+c
c

& #c+ +c 'c #1+<+c670009c%& %c c  #c' "ccc& cc c  c+c#c5))#c


5*)GK5*8D+c
c

& #c+ +#c(' #c+#c'c1#c ++c 'c #c1+<+c670009c& c;&"c 'c"c%c cc2#c! ''c 'c
! cc4 c  c+c#c5)B#c57G5K5*00+c
c

&%#+#c4#,+ +#c,#<+ +#c #1++#c3 # +c 'c$ #


++c670079c  c c%c ccc c+c +c
'+#cC#c*KB+c
c

&2 #c +#c   :  '#.+#c 1% # +#c 2#+#c 1% #+#c  % #,+#c
 #+4+c 'c 1&#1+c 65GGG9c 4c c :"c
 ccc& c2c "c ' cc&& c'"%"+c +c+c1+#c5BD#cG5*KG70+c
c

>>"#c1+#c1%  #c,+,+#c #c
+c 'c1' %#c+c6700B9c :''c'& cc. c c>"c!"c2 c
' c 'c&!:& c'!&+c%+c  c.2+#c57)#cD))KD8)+c
c

>>"#c1+#c > #c+,+#c$   &#c +#c #c


+c 'c1' %#c+c6700*9c :''c'"cccc
%' c. c "" c;&'cc cc' 2"c'  'c! +c$+c c  '+c
+c
#c500#c508D0K508D)+c
 "#c +<+cIc&!&#c.++c%' c. c& cc%& c' +c +c 2+c+c8#c*CGKB07+c700)+c
 "#c +<+#c 1 #c + +#c 1%#c ++#c #c +#c %"#c $+F+#c
&#c .++c # /+c %' c . c
& cc%& cc"cc+c +c+c2+c557#c5*)5K5*80+c700*+c
c
% #c
+cIc&%3#c +1+c c &' c&'"cc%& c : 'c! c  c c 2"c c''c!"c
2: 'c( +%+  c.2+cG7#c505K50G+c5GG8c
c
   c6#c%  cc   c
 c
cc 7c  c  c  c c' 
   c  c1 c $ >(7
/ c,  >c$ =&+c
c
 #c +,++#c4&#cR+#c,&#c +#c  %#c
+#cIc % '#c1+c;&c&cc :''c%  ccc
 'c%" c c''c!"cc ' c c  +%+  c.2+c57*#c5BCDK5)0*+c7007+c
c
  c,#c4c #cH% cL
+c700D +c&c 2 cc'c ' cc  c. c !"+c1(c c78cBBCKB)C+c
c
  c ,#c <c #c H% c LF+c 700D!+c   c . c '& c %c % c 'c   c . c  "+c c "c 8c
775*K775C+c
c
  c,#cH% cLF+c700D+c( :6 9c%c&&+cc"c8c7)K7G+c
c
 c 4#c .&'"c
#c ,c 1#c c #c 4 'c $<#c
 &'c ,.#c 4 "c #c
%!  c .+c 7007+c .#c  c 'c  c c . c
 %c c'c+c  c7*c5C0DK5C50+c
c
  cc0 c1c- c8c cc      c  c
c
   c
c  c  
c
c 
 c  
c c
 c#  c' c )&>& &7$c,  >c(*/+c
c
2

c @c -
c <c 2 c 6c     c  
c   c c 01#c   c c 
 
c c  
 c     c
1 c**(/==>* 7/c,  >c*(= &$+c
c
&#c +.+#c
&#c +.+#c "#c + +#c .#c +.+#c Ic  %#c +c F;&"c c  &c %c
! ccccc +& + +cB7)#c5*)K5B5+c5GGG+c
c
 c 0c ! 2 c c '
c <c <
 c c % 
c 1c  c 6c c rc c c  c c  c c   
 c
 
 c1 c $&r)=)(>$&7&/c
c
c #c,c
#c,c.<#c c#c  c #c%& c1
#c,  c.#c,c
+c700*+c&:c%  cc. c cc,&c
'c
$D0cc  c c 'c%c ' c!"c c+c%c  c.2c57BcG8DKGD)+c
c
! "
c0c "  c8c%  cc'
c#c0
  cc'   
c#c  
c

 c  cc c c
 c

c   c2 c cc


  c   c'c
c ))>*)7/ c,  >c)$)=/+c
c
2 c #.+#c 3 #
+$+#c 1 #+#c
%&'# +#c 'c  # + +#c 1 '#1+<+#c
 !#$++c 'c <'# ++c
6700)9c  cc%c%& c$)*c c c'c c&22 c 'c c "+c+c+#cB0#c55K5)+c
c
2 c #c +#< '#<+F+#c
! #c ++#cIc % '#c +ccc 'cc'  ' +cc '!c
c$%" "P  #c+c5D5K7*Bc6'+c #c+9+c('c2"c$#cc#c5GG)+c
c
 ;&c #c
%c #c '3&:1 c #c c $#c
 c 4#c ! c .+c 700D +c
 5c  & c %c %c
%"  c
*G 5c'& c%% c +c &cB)0cBB0KBBB+c
c
 ;&c #c
  >c #c ! c .+c 700D!+c  .ƒ:''c ' " c c Bc "c 58c !"c  c c . +c ( c 78c
))0)K))70+c
c
 ;&c +c700G+c%c2'ccc&cc% c & +cc c.2c1c)*c*0*K*77+c
c
  #c +#c  ' # +#c $' # ++#c &>:F '>#c +#c F & # + +#c
%>#4++#c H%&#H+#c ' &>#F+ +#c

 #+4+c c +c 6700)9c  'c  c c c 'c c H7Bc  c c 'c c )*c    c 2 +c
 &#B*D#c)8BK)8C+c
c
!  cc!c c% c c'3c0c,
2 c.c.  
 c?cc rcc  c  
c
c c&/cc c
  
 c
c
0c  c $/ /r&)&*>=$$7=$=c
c
!"  c6c0  c-c1 c8
c8c ccrc 
ccc1#0   c&/c   c' c  (>$*7&*c
,  >c)(&/+c
c
 >#c +#c
% %#cF+#%' #c+#<#c4+#H%&#cL+#c#c +c#/+c4ccc. c'& c  cc c 'c
"c75c%& c"%"+ c + &+c+c)7#c885K88D+c5GG*+c
c
3 #c +c670009c
 c& c 'c  c c:2 & +c& +c +#cBBD#c55DK5*)+c
c
3 #c +c 'c.#+++c670079c4  c c   c c c "c &cc  +c%+c  c.2+#c57*#cG0DKG5)+cc
c
3 #c +#c.#c+++#c &#c +: #c 'c1 #c++++c65GGD9+c  c&c'cc&'" c& cc22c
 cc  c %+c%+c  c.2+#cGC#c5CGK707+c
c
3 #c +#c& #c+#c4% #c$+ +c 'c,#c.+4+c65GC)9c:'&'c&%'&'c. c"%cc!! cc  c!'c
 +c& +c +#c5B8#c5GDK70B+cc
c
 &#c1+c%c%% cc'cc  +c+c+c*7#c*C*K*GB+c5GGD+c
c
! cc- c-c   2c#c%  cc#c
 c
cc 
c
c8c c 
 c  c c     cc
'c  c  cc0  
 c c &*>) &7&c,  >c)&)(/)+c
c
 # +#c4#.+
+#c, "#+#cF '#+c 'c "#$+c65GGG9c.cc,&C8c &c "ccccc+c$+c
 c  '+c
+c
#cG8#c50DD0K50DD)+c
c
2cH #+#c
>#+#c4 '%# +#c'= '' c'cF  #F+c 'c #
+$+c6700)9c & ccc c c. c'  c
+c%+c  c.2+#c578#c555K55D+c
c
& "#c +# #c +#c
>"'#c +#< #c +# #c $+ +#Ic . #c +c . c  c c  'c %c
 2cc% cc c%c'" c  c'&cc& cc +c +c+c*8#c
BBDKBBG+c700B+c
c
"3 " #c++c 'c #c,+
+c670089c. c'&!c 'c! c cc! c'&'c  c 2"cc  c c&+c&+c
4+#c*G*#c5CK77+c
c
< #c + +#c # + +c 'c'! # +c670059c
&&cc%c,&c%'c!&'cc. c 'cc cc
'&! 'c! c +c &#cB57#c80DK85B+c
c
ù c'c' cc6
cc cc  
c  c8.cc c  c

 c 
 c
c01#c c1c' c
c
 )=> &7/c,  >c)=* &+c
c
ù c.c1  ccA c.c
 cAcc   c./c c 
 c
c
   c cc 
 c  
c#  cc
' c ()>& &7$c,  >c(&/=(+c
c
ù c @c    c 6#c    c c    c  
c 
c c ' 
   c  c c c 0#.) .c  c
#  c0 c )(>$=7&)c,  >c)= & +c
c
<  #c+#c
%&#1+ +#c4 &# ++#c(  #+c 'cH%&#.+c670089c c!'"c ' c2"c'&c&c% c
cc+c1'#c50D#c*)CK*88+c
c
< % #c ,+ +#c 4"#c +F+#c #c $+ +#c Ic< #c +.+c c  'c  2 c c c L:'c + &c
*7D#cD7)KD7D+c5GCD+c
c
2c3c040c  &c5$0 cc46c -**)c% ccc  cc

c

ccc
"
c
 $c"$cc%
c c7c87 c*c-'-(,-'-+c
c
ù 
c c c c ' c <c 8   c c  c %c 01#c c c . c   c 
c   c 01#c   c

c   c /&/>&(7(c,  >c$)$/$/&+c
c
ù  c6c-  c8c  c.<c 
c0cù  ccc c    c  c  
c
c c   2 c 
c 
cc
 
c  c,
c1c# c c4#c**)*/r)>=/=7=//c
c
<#c.++#cc 'c1%#c+ +c670089c%c% cc! cc #c 'cc %cc  c 'c' +c. c
 c6 9+c
c
<#c+4+#c
%#c + +#c #c
+#cIc&#c ++cc):%"'""'c' c%c +c +c1+c%+c
787#cGGBCKGG)5+c5GCD+c
c
ù

c<%c
c ccc6
 "c-c6 cccc   c0c  c  
c  c 
 c  
cc c
  c c "
c1 c $$/ >)=)7*c,  >c&&$&& +c
c
<&#c+#c 2 " #+#c.#
+#c # +c 'c  2#,+c6700B9c  & cc& ccc c 'c
' 2cc!"c
 ':5+c &#cB*7#c8B0K8B)+c
c
L c #c c #c  c c #c "' c #c % 'c +c 5GG)+c 2c c ' c >"c c 2 &c &c c  c
F%c*BBc c c 'c!"c'c+c c&c57)c5G)K705+c
c
L&#c+#c
 #c+#c1"2#c+ +#c #c++c 'c #c,+c670009ccc cc%c c 'c ccc
%'&cc%& ccc&+c& +c +#cB)G#c5G)K707+c
c
L&#c+#c
2 #c+#c%#c.+4+#c#c+#c "#c + +#c % #c+ +#c< #c +1+#c   c#$++c 'c< #c+ +c6700)9c
&'cc c 2"c2 c  c&c  cc"+c1+c '+#cD*#c57*K5*0+c
c
L&#cL+#cR #c<+#c4#c
+$+#c #c4+#c4#c<++#cF&%#c$+ +#c #c++c 'c. #c+L+c670059cc c!c&c
&c1 5c 'c)*cc #cc"c 'c& +c +c+#c7C#c788K7D5+c
c
  ' #c+#c'#cc++#c #c+#c #c +#c
#c
+#c#c+c 'c '#c(+c670089c 'c%& cc2c1:'&'c
"'c'cc%c'cc"c% c"& c '&ccc22+c %+c. +c +#c7GD#c7GBK*07+c
c
  #c +#c #+#c # +#c !&#+#c%' #,+#c%& #+#c  #,+#c &%# +#c%&#+cc +c65GG89cc
":''ccc%c&c ')5c cc  c+c+c+c+#c7)5#c5K57+c
c
@c ?c ? c c   c 1c  c ùc  
c 8c c   c c  
c
c  c 1 3 c  2 c
 c 
 c

 c c ((>$*7)c,  >c()$*(+c
c
? c <c   
c  c  c  
 c c c      c c
 c <c  )/*(>&*7(c ,  >c
)))/ /+c
c
H%  # +c 'c$#
++c6700)9c%ccc%c1  5c&c&cc. c'&!: 'c! c +c+c c +#c*#c
)*5K)*G+c
c
H&#c4+c 'c' #
+ +c6700*9c
 c. c'  c%& %c  $c c c $ :. c+c
c6c #c
++9#c*00#c5)B7K5)BC+c
c
c
c
c
c
c

c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c
c