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Herbal Therapy: Alfalfa, the Anti-inflammatory

Natural Whole Food

Kyle J. Norton, Master of Nutrients

Health article writer and researcher; Over 10.000 articles and research papers
have been written and published on line, including world wide health, ezine
articles, article base, healthblogs, selfgrowth, best before it's news, the karate
GB daily, etc.,.
by Named 50 of the best health Tweeters Canada - Huffington
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes have been predated long before the
existence of modern medicine. Herbal plants have formed a fundamental
sources for conventional medicine in discovery of single ingredient medication,
including aspirin (from willow bark), quinine (from cinchona bark), and
morphine (from the opium poppy)......

Alfalfa is a flowering plant in the genus Medicago, belonging to the family

Fabaceae, cultivated all over the world as hay for cattle feeding, and used in
traditional medicine over thousands of year to treat high cholesterol, asthma,
osteoarthritis, rheumatoid arthritis, diabetes, enhanced digestive system,
bleeding disorder, kidney and urinary tract infection, etc.
North American aboriginals have used Alfalfa seed as food in making bread
and mush.

Inflammation is the natural response of immune system in regulated the

production of white blood cells and substances for protection against foreign

Alfalfa expressed significant anti-inflammatory effect through inhibited

production of proinflammatory cytokins during injure, foreign invasion and
free radical domino's action, etc....

According to the University of Maryland, novel pectic polysaccharide from

alfalfa(Medicago sativa L.) stem, showed significant anti-inflammatory effect
against mRNA expressions of the pro-inflammatory cytokine genes, especially
for IL-1 antibody.

The chloroform extract of alfalfa aerial part also is found to inhibit the function
of lipopolysaccharide (LPS) of Gram-negative bacteria in stimulated immune
responses in induced inflammation and suppressed LPS-mediated activation of
the extracellular signal-regulated the proinflammatory and prothrombotic
responses of nuclear factor kappa-B pathway.

The cinnamic acid derivatives and fatty acids active constituents of the extract
have also been found to be effective in ameliorated inflammation and immune
response through inhibition of nitric oxide (NO), tumor necrosis factor (TNF-
), and prostaglandin E2 (PGE2) all involved in the development of
inflammatory diseases.

Taking together, Alfalfa no doubt has processed an anti inflammatory effects by

inhibited free radicals, proinflammatory cytokins and hormone involved the
development of inflammatory and auto immune diseases.

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(1) Structural, thermal, and anti-inflammatory properties of a novel pectic
polysaccharide from alfalfa(Medicago sativa L.) stem by Chen L, Liu J, Zhang
Y, Dai B, An Y, Yu LL1.(PubMed)
(2) Chloroform extract of alfalfa (Medicago sativa) inhibits lipopolysaccharide-
induced inflammation by downregulating ERK/NF-B signaling and cytokine
production by Choi KC1, Hwang JM, Bang SJ, Kim BT, Kim DH, Chae M,
Lee SA, Choi GJ, Kim DH, Lee JC.(PubMed)
(3) Anti-Inflammatory Activities of Cinnamomum cassiaConstituents In Vitro
and In Viv by Jung-Chun Liao,1 Jeng-Shyan Deng,2 Chuan-Sung