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“Researchers and biotech executives foresee the day when the effects of many catastrophic diseases can be
reversed. The damaged brains of Alzheimer’s disease patients may be restored. Severed spinal cords may be
rejoined. Damaged organs may be rebuilt. Stem cells provide hope that this dream will become a reality.”

George Wolff,
The Biotech Investor’s Bible

1 Letter from Chairman & CEO
3 Life-Saving Opportunity
5 Cord Blood Stem Cells Save Lives
7 Future Possibilities
9 Cord Blood Stem Cell Process
12 Collection and Storage
13 Diseases Treated Today
14 Key Decision Criteria
17 The Cryo-Cell Difference
19 Protect Baby, Protect Mom
22 Next Steps

Dear Prospective Cryo-Cell Client,

Can you imagine the wonders that may unfold in your newborn’s lifetime?
Your baby’s cord blood stem cells may hold the key to many of those wonders.

For decades, stem cells have successfully treated a host of devastating
diseases. In recent years, however, stem cell research has demonstrated even
greater promise for future regenerative therapies that may potentially treat
conditions that affect millions like Alzheimer’s, breast cancer, diabetes, heart
disease and stroke, to name a few.

At the magical moment of your newborn’s birth, you will have the once-in-
a-lifetime opportunity to safeguard your family’s future health and well-being
by preserving your baby’s cord blood stem cells.

As a global industry leader among private family cord blood banks, Cryo-Cell
is renowned for extraordinary quality, competitive value, legendary client
satisfaction and innovative stem cell solutions.

Throughout our brochure we have included the perspectives from some
real-life clients, in their very own words. We invite you and your family to join
our Cryo-Cell family of over 200,000 clients worldwide. Together we are
“We chose Cryo-Cell to preserve her cord blood because preserving cord blood is like “Banking on Miracles®”.
buying insurance. You hope you never need it, but you’re glad if you do.”
Warmest regards,
Sarah Marie’s Mom,
Proud Cryo-Cell Client

Chairman & CEO

Life-Saving Opportunity
Once discarded as medical waste, umbilical cord blood is now widely known
to be a rich, noncontroversial source of stem cells—the building blocks of all
cells in our blood and immune system. Stem cells have the ability to help
regenerate a patient’s immune system, particularly if it has been damaged or
destroyed by therapies such as chemotherapy or radiation. Cord blood stem
cells may be used in place of bone marrow or stem cells from other sources
for transplantation.

Banking your newborn’s umbilical cord blood stem cells using Cryo-Cell®’s
U-Cord® service will provide your family with confidence and peace-of-mind
should stem cells ever be needed for the medical treatment of your newborn
or related family member.

Privately stored in our safe, secure, state-of-the-art facility, your newborn’s
cord blood cells are immediately available to you whenever needed. Stem
cells harvested using the U-Cord service are a 100 percent match for your
baby, and have at least a one-in-four chance of matching a sibling. They
may also match other family members.

By choosing Cryo-Cell you can also save for college. Through our industry-
exclusive partnership with Upromise®, a college savings service, Cryo-Cell
contributes a percentage of processing and storage fees to your newborn’s
college savings account.

Cryo-Cell Client for LifeTM, $10,000 Cryo-Cell CaresTM and Protect Baby,
Protect MomSM are additional exclusive services that are only available to
“We decided to bank our baby’s cord blood with Cryo-Cell after months of research and Cryo-Cell clients. (See page 17 for information.)
the recommendation by our doctor. Cryo-Cell offered everything the other companies did
at a lower fee… it’s nice to have peace of mind in case something happens in the future.
With advances in technology, so many diseases and cancers can be treated with cord
blood, and my son’s (and family’s) life is too precious not to take precautions.”

Proud Cryo-Cell Client

Cord Blood Stem Cells
Save Lives
The first cord blood stem cell transplant occurred in 1988 to treat a condition
known as Fanconi’s anemia. In just over two decades, cord blood stem cells
have now been used in more than 12,000 transplants worldwide to treat
approximately 75 diseases including cancers, leukemia, lymphoma and certain
immune system disorders.

While preserved cord blood stem cells do not guarantee treatment or cure for
every disease, studies have shown that recipients of stem cells from a related
donor’s umbilical cord blood have greater success and fewer complications.

Since 1992, thousands of Cryo-Cell returning clients have chosen our
signature U-Cord® service as their families expand. This speaks volumes
about our industry leading quality, competitive value and legendary client
satisfaction. With our industry-exclusive Cryo-Cell Client for LifeTM Program,
returning clients enjoy the same pricing for children born later in life.
(See page 17 for information.)

We sincerely hope that your family will never have to use your child’s cord
blood stem cells for medical therapy. Should the need ever arise however;
these cord blood stem cells are immediately available for medical treatment
and at no additional cost from Cryo-Cell for retrieval. As a result, your family
may potentially save precious time and considerable expense associated with
“We chose Cryo-Cell because it was the best all around choice for our little angel. The
sourcing stem cells from a public cord blood bank.
staff at Cryo-Cell is very friendly and accessible to answer all your questions and go out
of their way to help you. We are very happy with Cryo-Cell and would recommend it to
anyone looking into cord blood banking. The price is very competitive. They also lock in
the rate for your next child. We are sure as parents that our children will appreciate this
biological insurance plan. It’s a small price to pay for knowing that you are ahead of the
game should a medical need arise.”

Saanvi’s Parents,
Proud Cryo-Cell Clients

Future Possibilities
Preserving your newborn’s umbilical cord blood stem cells at Cryo-Cell is
a healthcare investment that may potentially grow in value as future stem
cell therapies emerge. An increasing number of experimental clinical studies
are underway at prominent research institutions in the U.S. and abroad that
utilize cord blood stem cells to treat a broad range of conditions such as
juvenile diabetes, cerebral palsy and spinal cord injury.

The promise of future advancements offers hope that cord blood stem
cells may one day be used to treat an even broader range of diseases, some
for which cures do not currently exist.

Future potential therapeutic applications utilizing cord blood stem cells
may include:

Neurological Disorders
Alzheimer’s, Parkinson’s, Stroke, Lou Gehrig’s (ALS), Muscular Dystrophy

Soft Tissue Tumors
Breast Cancer

Cardiac Tissue Regeneration
Heart Attacks

Neural Regeneration
Spinal Cord Injury

Autoimmune Diseases
Diabetes, Lupus, Rheumatoid Arthritis
“This was one of the best investments that we could have made. Whether we will need
them or not, the cord blood stem cells are there just in case. We live in a wonderful
growing world, with so much advancement in technology. You never know what the
future will hold.”

Proud Cryo-Cell Clients
Cryo-Cell’s good manufacturing practice/good tissue practice laboratory

State-of-the-art cryogenic storage system Preparing stem cell specimens for long-term cryopreservation

Cord Blood
Stem Cell Process
Cord blood can only be collected at the time your baby is delivered, after
the umbilical cord has been clamped and cut. There is no pain or risk to
you or your baby.

Following the collection of your newborn’s cord blood, the specimen is
transported to Cryo-Cell’s state-of-the-art laboratory facility for testing,
processing and storage. The specimen is frozen in the vapors of liquid
nitrogen to extremely cold temperatures of approximately -195°C.

This process, known as cryopreservation, halts the cellular activity of the
stem cells almost as if they are frozen in time. When cryopreserved in
accordance with industry standards, cord blood stem cells remain vital for
many years. Cord blood stem cell specimens harvested from some of
Cryo-Cell’s first clients have been safe and securely cryopreserved for
nearly 20 years.

Should the medical need arise the stem cells can be retrieved and thawed
in preparation for use in a transplant at a certified medical facility. Every
cord blood stem cell specimen released to date for transplant from Cryo-Cell
has been viable upon thaw. Our Company’s perfect record allows us to offer
the Cryo-Cell Cares $50,000 Payment Guarantee. (See page 17 for information.)

Cryo-Cell has a significant growing number of successful life-saving stem
cell transplants which are frequently updated on our transplant matrix.

Newborn baby, one minute old
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Collection and Storage Diseases treated today
Acute Leukemias Inherited Metabolic Disorders
- Acute Lymphoblastic Leukemia (ALL) - Mucopolysaccharidosis (MPS)
Collecting your baby’s cord blood is simple and safe. When your baby is - Acute Myelogenous Leukemia (AML) - Hurler Syndrome (MPS-IH)
born, the cord is clamped and cut. Using the supplies provided in the - Acute Biphenotypic Leukemia - Scheie Syndrome (MPS-IS)
Cryo-Cell collection kit, your healthcare professional collects the blood - Acute Undifferentiated Leukemia - Hunter Syndrome (MPS-II)
- Sanfilippo Syndrome (MPS-III)
that remains in the umbilical cord and placenta. Chronic Leukemias - Morquio Syndrome (MPS-IV)
- Chronic Lymphocytic Leukemia (CLL) - Maroteaux-Lamy Syndrome (MPS-VI)
- Juvenile Chronic Myelogenous Leukemia (JCML) - Sly Syndrome, Beta-Glucuronidase Deficiency
Next: - Juvenile Myelomonocytic Leukemia (JMML) (MPS-VII)
- Adrenoleukodystrophy
Myelodysplastic Syndromes - Mucolipidosis II (I-cell Disease)
1. You may arrange for the transport of your specimen by simply calling a - Myelodysplastic Syndrome - Krabbe Disease
Cryo-Cell Transportation Coordinator 24/7/365 at 1-800-STOR-CELL, - Refractory Anemia (RA) - Gaucher’s Disease
- Refractory Anemia with Ringed Sideroblasts (RARS) - Niemann-Pick Disease
option 1. - Refractory Anemia with Excess Blasts (RAEB) - Wolman Disease
- Refractory Anemia with Excess Blasts in - Metachromatic Leukodystrophy
Transformation (RAEB-T)
2. Once your specimen is received in Cryo-Cell’s laboratory, the cord blood - Chronic Myelomonocytic Leukemia (CMML) Histiocytic Disorders
is tested for microbiological contamination. It is then processed with Hespan®, - Familial Erythrophagocytic Lymphohistiocytosis
Hematopoietic Cell Disorders - Histiocytosis-X
a plasma volume expander derived from natural sources of starch, to reduce - Aplastic Anemia (Severe) - Hemophagocytosis
the red blood cells while concentrating the white blood cells and stem cells. - Fanconi Anemia
- Paroxysmal Nocturnal Hemoglobinuria (PNH) Inherited Erythrocyte Abnormalities
- Pure Red Cell Aplasia - Beta Thalassemia Major
3. Stem cells are quantified using flow cytometry, a technique for counting - Sickle Cell Disease
and examining microscopic particles, such as cells and chromosomes, by Myeloproliferative Disorders
- Acute Myelofibrosis Inherited Immune System Disorders
suspending them in a stream of fluid and passing them by an electronic - Agnogenic Myeloid Metaplasia (myelofibrosis) - Ataxia-Telangiectasia
detection device. The stem cells are then mixed with dimethyl sulfoxide - Polycythemia Vera - Kostmann Syndrome
- Essential Thrombocythemia - Leukocyte Adhesion Deficiency
(DMSO) and dextran which are used as cryoprotectants, and stored in a - DiGeorge Syndrome
compartmentalized cryobag. Lymphoproliferative Disorders - Bare Lymphocyte Syndrome
- Non-Hodgkin’s Lymphoma - Omenn’s Syndrome
- Hodgkin’s Disease - Severe Combined Immunodeficiency (SCID)
All bags include a 20 ml and 5 ml sample. Three segments for testing are - SCID with Adenosine Deaminase Deficiency
Phagocyte Disorders - Absence of T&B Cells SCID
overwrapped for additional protection during cryopreservation. The stem - Chediak-Higashi Syndrome - Absence of T Cells, Normal B Cell SCID
cells, referred to as specimens, are stored in Cryo-Cell’s highly secured and - Chronic Granulomatous Disease - Common Variable Immunodeficiency
- Neutrophil Actin Deficiency - Wiskott-Aldrich Syndrome
monitored cryogenic storage facility. - Reticular Dysgenesis - X-Linked Lymphoproliferative Disorder

Plasma Cell Disorders Other Inherited Disorders
4. Maternal blood is tested by an outside Clinical Laboratory Improvement - Multiple Myeloma - Lesch-Nyhan Syndrome
Amendments (CLIA) certified and Food and Drug Administration (FDA) - Plasma Cell Leukemia - Cartilage-Hair Hypoplasia
- Waldenstrom’s Macroglobulinemia - Glanzmann Thrombasthenia
registered laboratory for hepatitis, HTLV, HIV, CMV and syphilis. If any - Osteopetrosis
of these screening tests are positive, confirmatory tests, if appropriate, are Other Malignancies
automatically performed. - Breast Cancer Inherited Platelet Abnormalities
- Ewing Sarcoma - Amegakaryocytosis/Congenital Thrombocytopenia
- Neuroblastoma
- Renal Cell Carcinoma

Autologous stem cells may not be useful in the treatment of certain of the above diseases
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Key Decision Criteria
As you prepare for the birth of your baby, you are balancing multiple Financial Stability
priorities in the midst of a flurry of activities. It is important to remember Financial stability is also an important criterion. Cryo-Cell is a publicly-traded
that your decision to bank cord blood is one that may potentially impact company governed by the SEC (Securities and Exchange Commission),
your family’s future healthcare long after your baby is born. which means our financial information is audited by an independent firm
and is available to the public. Cryo-Cell has significant cash reserves and is
Here are some factors to consider: debt-free. As reflected in our publicly available financial statements, we are
financially stable with consecutive quarters of profitability.
Private Family vs. Public Cord Blood Bank
Storing your baby’s cord blood with a private facility like Cryo-Cell will Control of Processing and Storage
guarantee that these preserved cord blood stem cells, which are a 100 percent Some cord blood banks are simply marketing outlets that do not perform
match to your newborn and possibly to other family members, will be available their own processing or storage. Cryo-Cell operates its own state-of-the-art
only to you and your family. Stem cells donated to a public facility become processing, testing and cryopreservation operation. We are in complete
the property of a publicly accessible cord blood bank registry and are available control of every step, ensuring the highest quality available today.
on a first-come, first-served policy. If needed, a donor’s cells may already
have been used by someone else. Value
We encourage you to compare Cryo-Cell’s industry-leading quality, impeccable
By choosing private family storage, you will not pay extra fees associated client service, exclusive features and extraordinary value versus other cord
with sourcing a specimen match and you will have the assurance that your blood banks, many of which are higher priced. We believe that Cryo-Cell’s
newborn’s specimen will be available if needed. premium quality, differentiated features and competitive price say it all.

Quality Leadership
Cryo-Cell operates a state-of-the-art laboratory facility that is FDA registered,
cGMP-/cGTP-compliant and is licensed in all states that require licensure.
In addition to our AABB (formerly known as the American Association of
Blood Banks) industry accreditation, we are ISO 9001:2000 certified by BSI,
an internationally recognized quality assessment organization. Our combined
list of licenses and accreditations has established Cryo-Cell as the industry
quality leader.

Longevity and Clients
A good indication of whether a company will be around in the future is to
consider how long they’ve been in business and how many clients have
entrusted that company. Founded in 1989, Cryo-Cell is one of the largest and
most established family cord blood banks with over 200,000 clients worldwide.

The Cryo-Cell Difference

Our Features Our Value to Clients

Cryo-Cell is the only cord blood bank in the world to offer this exclusive ground-
breaking combination that includes our signature U-Cord collection service with
Protect Baby,
our proprietary Célle menstrual stem cell technology. This premium bundle offers
Protect Mom
the potential to extend prospective safeguards for your family’s future health and
well being.

The $50,000 Cryo-Cell In the event a client’s cord blood, which was processed and stored by Cryo-Cell,
Payment GuaranteeTM is used for transplant and fails to engraft, we will pay the Client $50,000.2

The $10,000 Cryo-Cell In order to help ease the financial burdens of certain transplant procedures,
CaresTM Payment Program Cryo-Cell will provide clients $10,000 to cover associated costs of such therapies.2

Cryo-Cell Client for As a member of the Cryo-Cell family, clients who enrolled December 1, 2005 or
LifeTM Program after will enjoy the same pricing structure for the life of the parent.

Cryo-Cell values our clients, their friends and families. Refer new clients to
Cryo-Cell’s Referral
Cryo-Cell and you will receive one year of annual storage free for each referral
who enrolls, processes and stores with our service.2

Cryo-Cell’s industry-exclusive agreement with Upromise offers clients two
Cryo-Cell and Upromise®
percent of all fees as cash back for college. This is a wonderful way to save
College Savings Program
for a child's education for our clients who enroll at

You may arrange for the transport of your specimen to our facility by simply calling
a Cryo-Cell Transportation Coordinator 24/7/365 at 1-800-STOR-CELL, option 1.
There is no additional charge for this service when utilizing Cryo-Cell’s designated
“Choosing Cryo-Cell to store our daughter’s stem cells was a no-brainer for us. I courier. However certain circumstances may dictate the necessity of utilizing an
Transportation Courier
couldn’t, as a mother, let any opportunity to save her life, should a reason occur, slip by. alternative courier (i.e. non-business days or holidays). In this event, a Cryo-Cell
The ‘what if ’s’ and ‘I should have’s’ would have been too much for me to bear had I Transportation Coordinator will assist you with scheduling and pricing for alternative
couriers who will accommodate expedited delivery. The specimen should be kept
not stored the precious cells. Storing your child’s stem cells is an insurance policy you at room temperature prior to transport.1
pray you never have to use. Cryo-Cell made it so easy and hassle free as well. During
Cryo-Cell requires no fee at time of enrollment. Payment is not required until
the time of your baby’s special arrival, all you want to do is concentrate on your new No enrollment fee
after your baby is delivered.1
bundle of joy, and that is exactly what I did! Thanks Cryo-Cell for everything!”
You can participate in the U-Cord service for as little as $57/month based on our
Financing plans available 48-month financing plan. We also offer 6- and 12-month plans and accept major credit
Lauren Elizabeth’s Mom, or debit cards. You must quality with CareCredit to utilize any of our financing plans.2
Proud Cryo-Cell Client

1. These programs and services are available only to clients enrolling under the new service agreement and fee structure, available beginning December 1, 2005. The above offerings
cannot be made retroactively to clients who have already given birth, or to those who enrolled before December 1, 2005 and who have not signed a new service agreement. Clients
who have a due date of December 1, 2005 or later are welcome to participate in the offerings above under our new service agreement and fee structure. Prices, programs, and terms
subject to change at any time.
2. See limitations and exclusions in our program terms and conditions documents. The $50,000 Cryo-Cell Payment Guarantee™ and the $10,000 Cryo-Cell Cares™ Payment are part
of the Cryo-Cell Cares™ program, which is outlined in Exhibit 6 of the contract.

Protect Baby,
Protect Mom
Expectant families can also extend healthcare protection with Cryo-Cell’s
exclusive Protect Baby, Protect Mom service. The program bundles our
signature U-Cord collection service with our exclusive Célle service and
offers the best value.

The revolutionary Célle service, discovered and launched by Cryo-Cell,
empowers women to safely and easily collect potentially life-saving stem
cells harvested from their own menstrual blood. New mothers can complete
their Célle service following the birth of their newborn once their monthly
cycle resumes.

Célle stem cells have demonstrated the potential to transform into many
other vital cell types which may make them ideal in the development of
future regenerative therapies. Cryo-Cell has several pre-clinical research
and development collaborations underway utilizing Célle technology that
may lead to the future treatment of conditions such as stroke, diabetes,
heart disease and breast cancer. Célle menstrual stem cells are a 100 percent
match for the female donor and may possibly match a first-degree relative
such as a parent, sibling or child.

Cryo-Cell’s exclusive Protect Baby, Protect Mom combination service
provides a family healthcare investment that may potentially increase in
value over time as regenerative medical therapies emerge.

“…We are going to be parents again and we plan to save this baby’s cord blood also. I
think it is a wonderful thing that we can do this and just in case something happens to
the kids or even us parents, there is something there to help us or other family members.
We try to tell anyone who is expecting about cord blood banking and Cryo-Cell. Thank
you so much for all that you do.”

Jimmie’s Mom,
Proud Cryo-Cell Client
“…Connor was our first child. Of course, we wanted to do everything just perfect so
we did all the research. It was clear that Cryo-Cell was the best choice. The pricing is
competitive but more importantly, Cryo-Cell has been around the longest and had so
many wonderful success stories to read about.We had no question in our hearts and/or
minds that Cryo-Cell was the best choice for us.When the time comes for another baby,
we’ll be banking with Cryo-Cell again!”

Connor’s Mom,
Proud Cryo-Cell Client