Cefmetazole (cephalosporin generasi II

)
Pronunciation Mechanism of Action
U.S. Brand Names Pharmacodynamics/Kinetics
Generic Available Usual Dosage
Synonyms Monitoring Parameters
Pharmacological Index Test Interactions
Use Mental Health: Effects on Mental
Pregnancy Risk Factor Status
Contraindications Mental Health: Effects on
Psychiatric Treatment
Warnings/Precautions
Dental Health: Local
Adverse Reactions
Anesthetic/Vasoconstrictor
Overdosage/Toxicology Precautions
Drug Interactions Dental Health: Effects on Dental
Stability Treatment
Patient Information
Nursing Implications
Dosage Forms
References

Pronunciation
(sef MET a zole)

U.S. Brand Names
Zefazone®

Generic Available

No

Synonyms
Cefmetazole Sodium

Pharmacological Index

Antibiotic, Cephalosporin (Second Generation)

Use

Second generation cephalosporin, useful for susceptible aerobic and anaerobic
gram-positive and gram-negative bacteria; surgical prophylaxis, specifically
colorectal and OB-GYN

Pregnancy Risk Factor

B

may cause antibiotic-associated colitis or colitis secondary to C. renal dysfunction. superinfection Overdosage/Toxicology Symptoms of overdose include neuromuscular hypersensitivity. fever. interstitial nephritis. toxic epidermal necrolysis. seizures. Drug Interactions Increased effect: Probenecid may decrease cephalosporin elimination Increased toxicity: Furosemide. epigastric pain. aplastic anemia. or 6 weeks when frozen. hemolytic anemia. neutropenia. erythema multiforme. respiratory distress. otherwise most treatment is supportive or symptom directed. candidiasis. anaphylaxis. hypotension. 7 days when refrigerated. hemorrhage. difficile Adverse Reactions Contains MTT side chain which may lead to increased risk of hypoprothrombinemia and bleeding. vaginitis Other reactions with cephalosporins include anaphylaxis. headache. colitis. use with caution in patients with a history of penicillin allergy especially IgE-mediated reactions (eg. shock. Stevens-Johnson syndrome. aminoglycosides may be a possible additive to nephrotoxicity Stability Reconstituted solution and I. after freezing.V. toxic nephropathy. dyspnea. bleeding. prolonged use may result in superinfection. Dermatologic: Rash Gastrointestinal: Diarrhea <1%: Pain at injection site. epistaxis. pseudomembranous colitis. thawed solution is stable for 24 hours at room temperature or 7 days when refrigerated .Contraindications Hypersensitivity to cefmetazole or any component or cephalosporins Warnings/Precautions Modify dosage in patients with severe renal impairment. cholestasis. urticaria). agranulocytosis. pancytopenia. hot flashes. infusion in NS or D5W solution are stable for 24 hours at room temperature. convulsions especially with renal insufficiency. many beta-lactam antibiotics have the potential to cause neuromuscular hyperirritability or seizures Hemodialysis may be helpful to aid in the removal of the drug from the blood. phlebitis.

thus inhibiting cell wall biosynthesis. delusion. Fehling's solution). false-positive serum or urine creatinine with Jaffé reaction Mental Health: Effects on Mental Status May cause nervousness. observe for signs and symptoms of anaphylaxis during first dose Test Interactions Positive direct Coombs'. false-positive urinary glucose test using cupric sulfate (Benedict's solution. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested. and depersonalization with cephalosporins .V. repeat 8 and 16 hours later Dosing interval in renal impairment: Clcr 50-90 mL/minute: Administer every 12 hours Clcr 10-50 mL/minute: Administer every 16-24 hours Clcr <10 mL/minute: Administer every 48 hours Monitoring Parameters Monitor prothrombin times.Mechanism of Action Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin- binding proteins (PBPs) which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. case reports of euphoria. Pharmacodynamics/Kinetics Absorption: I.: Well absorbed Distribution: Widely distributed Protein binding: 65% Metabolism: <15% Half-life: 72 minutes Elimination: Renal Usual Dosage Adults: I. Clinitest®.M. illusions.: Prophylaxis: 2 g 30-90 minutes before surgery or 1 g 30-90 minutes before surgery.

additional contraceptive measures are necessary." N Engl J Med. "Drug Therapy. 1988. May interfere with oral contraceptives. Beta-Lactam Antibiotics (2). or mucus in stool or urine." Mayo Clin Proc. Drink 2-3 L fluid/day. pus. Avoid alcohol during therapy and for 72 hours after last dose (may cause severe disulfiram-like reactions). 1999. 1988. Breast-feeding precautions: Consult prescriber if breast- feeding. 1989. vaginal itching or drainage. unresolved diarrhea. Jones RN. "Cefmetazole Versus Cefoxitin in Prevention of Infections After Abdominal Surgery. or I. 318(7):419-26. 318(7):419-26 and 318(8):490-500. use another form of testing.V. blood. "Review of the In vitro Spectrum and Characteristics of Cefmetazole (CS-1170). If diarrhea occurs. 23(Suppl D):85-8. 1989." J Antimicrob Chemother. . as sodium: 1 g. sores in mouth. May cause false- positive test with Clinitest®. "Beta-Lactam Antibiotics. 2 g References Donowitz GR and Mandell GL." N Engl J Med. 1988. Plouffe JF.Mental Health: Effects on Psychiatric Treatment May rarely cause neutropenia. 23(Suppl D):1-12. rash. easy bleeding or bruising. Donowitz GR and Mandell GL. yogurt or buttermilk may help. use caution with clozapine and carbamazepine Dental Health: Local Anesthetic/Vasoconstrictor Precautions No information available to require special precautions Dental Health: Effects on Dental Treatment No effects or complications reported Patient Information This drug is administered I. Report severe. Nursing Implications Do not admix with aminoglycosides in same bottle/bag Dosage Forms Powder for injection. unusual fever or chills." J Antimicrob Chemother. Marshall WF and Blair JE. or respiratory difficulty. Donowitz GR and Mandell GL. Beta-Lactam Antibiotics (1). "Drug Therapy.M. 318(8):490-500. "The Cephalosporins." N Engl J Med. 74(2):187-95.