International Journal for Pharmaceutical

Research Scholars (IJPRS)
V-5, I-2, 2016 ISSN No: 2277 - 7873

A Review on Phytopharmacological Activities of Operculina Turpethum
Shatabdi Ghosh, Umamaheswari S.*, Uma Maheswara Reddy C.
Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra University, Chennai, India.
Manuscript No: IJPRS/V5/I2/00065, Received On: 21/04/2016, Accepted On: 27/04/2016

Secondary metabolites from natural sources play a crucial role in the treatment of various ailments.
Traditionally Operculina turpethum has been used to treat gastrointestinal disturbances and asthma.
Therapeutically the plant has activity against tumor, tuberculosis, malaria etc. In the present review aim
is to search literatures for the phytochemical analysis and pharmacological activities of Operculina
turpethum stem and roots. The compiled data may be helpful for the researchers to focus on the priority
areas of research yet to be discovered. Complete information about the book has been collected from
various books, journals and Ayurvedic texts of the last 10 years. Pharmacological and phytochemical
particulars of the plant were extracted from various published reports focusing on the safety profile of
the plant. This review concludes various phytoconstituents isolated so far and the various
pharmacological activities reported from the roots and stem of Operculina turpethum.
Operculina Turpethum, Convolulaceae, Pharmacology, Phytochemical Analysis
Complimentary of alternative medicine is rapidly first line defense in combating dreadful disease
increasing worldwide to meet the market of today. Traditional medicine have not however
demands for herbs that is lightly to remain high been incorporated in most national health
due the bioactive constituents present in it and systems and the potential of service provided by
yet cannot be prepared synthetically1. Medicinal the traditional medical practitioner is not fully
plants play a vital role in all most all the utilized. Operculina turpethum Linn. Belonging
traditional system of medicine and folklore to family convolvulaceae is widely distributed
practices. In concordance India has rich bio throughout India China Sri Lanka and Australia.
diversity with flourished heritage of tradition The plant is commonly known as Trivrit and
medicines. One such example constitutes exists in 2 varieties namely Aruna or Shweta
Artemisinin an active anti-malarial compound (Operculina Turpethum) and Shyama (Ipomea
isolated from Artemisia annua of Chinese Petaloides)2. Root of Trivrit is used on a large
medicine. Conventional as well as western scale in disorders like skin peptic acid disorders
medicine comprises mostly medicinal and constipation. In Ayurveda this has been
components that are derived from plants. In the included among the 10 purgative herbs (i.e.
present scenario around 88% of the global Bhedaniya Mahakashaya), group of ‘ten antidote
population focuses on plant derived medicines as herbs’ (i.e. Vishaghna Mahakashaya), group of
‘ten herbs supportive for therapeutic enema’ (i.e.
*Address for Correspondence:
Umamaheswari. S Ashthapanopag Mahakashaya), group of colon
Department of Pharmacology, Faculty of Pharmacy, cleanser, antitumor & antidote herbs. (i.e.
Sri Ramachandra University, Chennai, India.
E-Mail Id: Shyamadi Gana), and in the group of ‘herbs
eliminating the toxins (i.e. vitiated Doshas) from

© Copyright reserved by IJPRS 82

Tryushanadi Churna etc7. Dysentery Class : Dicotyledons Abhaya Modak – Constipation. Avipattikar Churna. and is occasionally grown in gardens. cardiotonic. About 135 herbal and herbomineral formulations used in ayurvedic medicine comprise of Operculina turpethum as an important ingredient3. Nishoth lacrimation4. Basically the bark of this plant is used as Ayurvedic: Trivrtaa. Adhobhagahar English: Turpeth. Rechani. Vyoshadi Gutika. Kaalaa. a purgative whereas the leaves are used as Saralaa.) Silva Manso Trivtit Arishta– Abdominaltumor 9 Binomial name: Operculina turpethum (L. Abhayadi Modak. Triputaa. Suvahaa. turpethum (L. Br. Nishotra. Shyaama. An acidic moiety is also been reported to be present in a large quantity in © Copyright reserved by IJPRS 83 . Tribhandi. vascular plants Ayurvedic Preparations & Formulations Super division : Spermatophyta. Narach Churna. Africa & Taxonomical Classification Australia while is naturalized in West Indies. Some of them are Trivrit Avaleha‚ Panchasama Churna Alambushadi Yoga Malashodhak Churn. Trivrta. Kalyanak Gud.) Silva Phytochemical Features Manso6 An analogue of Jalapine and convolvulin. Therapeutic Order : Solanales purgative Family : Convolvulaceae Kalyanak Gud – GI disorders. Common Names turpethin is present in almost 10% of the total Latin : Ipomoea turpethum (L. seed plants Trivit Avaleha – GI disorders Division : Angiosperma Panchasama Churna – Constipation. Indian Jalap Gana)3. Probably the roots bark and seeds Kumbha. tumors Genus : Operculina Jambvadi Taila– Gonorrhea Species : O.e. Convolvulus turpethum turpethum. The fresh juice of leaves Siddha/Tamil: Karunchivadai6 finds use in ophthalmia as inducer of Unani: Turbud.) phytoconstituents present in Operculina R. Traditional Uses Plant Profile Traditionally root bark of Operculina turpethum Operculina turpethum is a perennial climber with administered as a powder along with vehicles long fleshy rots and long twisting pubescent like fermented rice water milk cereal water stems that turns very tough and brown when old5. Sukhavirechak Churna. Agnimukh loha. A Review on Phytopharmacological Activities of Operculina Turpethum lower half of the body’ (i.8 Subkingdom : Tracheobionata. Geographical Description Figure 1: Operculina turpethum Operculina turpethum is native to Asia. As a therapeutic purgative agent in GI and skin disorder ascites and various cancers. Shyaamaa contain cardiac glycosides such as neriodorin neriodorein and karabin. The Kingdom : Plantae plant is grown throughout India up to 1000 m. triphala black pepper sugarcane juice cow and goats urine..

The ethanolic stem bark extracts was glucopyranoside from the root bark of administered orally at 100mg/kg to study their Operculina turpethum and explained its anti-oxidant property and further DMBA as an chemistry with spectral analysis. Silymarin Turpethinic acids-A.13-0. Stigma -5. in steroidal glycoside. al.e .al explained the anti diarrhoeal Sureh kumar et. Stigma -5. al. The steroidal inducer was used in 20 mg for a period of 45 glycoside was isolated from the ethanolic root days. and hydro alcoholic stem extracts of Operculina glucopyranoside from the root bark of turpethum for their anti-ulcerative properties Operculina turpethum in NDMA induced renal against ranitidine as standards. Protective effects of Operculina turpethum stem Phytochemical Studies extracts in DMBA induced breast cancer in rat Veena Sharma et. al. The extracts were tested in using the methanolic extract of Operculina several human pathogenic bacteria and the turpethum in mice and the LD50value was found minimum inhibitory concentration (MIC) was to be 1917. The in mice. The purgative was used as a standard drug and showed action of Operculina turpethum is mainly due to significant increase in hepatoprotective activity13.22dien-3-o-b-D. turpethin and can be considered as a relatively Cytotoxic Activity safer substitute for jalap6. evaluated the methanolic steroidal glycoside. extract and the isolated compound respectively12. The results showed remarkable reduced a dose of carcinogenesis in male mice and hepatopathy in 100mg/kg of body weight in aspirin + pyloric the liver of mice. al reveals the presence of a models was studied by Anbuselvam et. The hydro-alcoholic stem extracts shown administered in mice and it showed significant better results when compared to the methanolic recovery at 400 mg/kg and 50 mg/kg for the extract16. lipid peroxidation and increased anti-oxidant levels with a decrease in tumor weight14. A dose of 10mg/kg of loperamide was ethanolic extract of Operculina turpethum used as a standard. al 15. 2007. Shigella sonnei and Singh et. potency. reported in arrange from 0. The activity was tested by disc-diffusion Pharmacological Studies method against Bacillus subtilis. Anti-Microbial Property hydroxy phenyl)-ethyl]-acrylamide derived from The anti –microbial potency of the petroleum the ethyl acetate fraction of the Ipomoea ether and ethanolic extracts of Operculina turpethum stem extracts and was confirmed by turpethum were studied for their anti-microbial extensive spectral analysis11.e activity in a dose dependent manner. al explained the therapeutic Anti-Ulcer Activity anti-nephrotoxic efficacy of the isolated a Vidya Ignatius et. Anti-Diarrhoeal Activity Hepatoprotective Activity Huma Shareef et.C. A Review on Phytopharmacological Activities of Operculina Turpethum Operculina turpethum in almost 5 forms i.66 mg/kg12. The root extracts showed administered intraperitoneally 100-2000 mg/kg promising results in a dose dependent manner body weight showed significant hepatoprotective © Copyright reserved by IJPRS 84 .22dien-3-o-b-D.3-(4-hydroxy-phenyl)-N-[2-(4. Veena Sharma et. The ethanolic extract of the ligation induced ulcer models of male Albino roots and also the isolated compound were rats. evaluated the effects of Oerculina turpethum ethanolic root hepatoprotective potential of Operculina extract through castor oil-induced diarrhea model turpethum by inducing paracetamol in rats. Streptococcus haemolytica and gram negative bacteria Toxicity Studies Pseudomonas aeruginsa. Rashid et. in 2014 found the acute oral toxicity Shigella dysenteriae.75 mg/ml by Nephroprotective Activity Jahangir Alam et.D& E3. al explained the presence of an acrylamide i.B. al.

Indian Materia Medica Vol I. Nadkarni. turpethinic acid A-E in large amount. Vol II. (2001). R. A Review on Phytopharmacological Activities of Operculina Turpethum when administered orally in three different CONCLUSION doses17. Nighantu. Indian Materia Medica. P. (2008). al. experimental rat models at 100mg/kg of body 2. 6. Department of ISM & H. cytotoxic. Part I. P. Thomas. The anti-arthritic potential of the root extracts of hepatoprotective. (1999). 4. A (India). Anti-Diabetic Activity REFERENCES Sankariah Pulipaka et.. Samuel Mathew. Vol III. The pharmacological actions concentration with BSA was tested for the of the plant may be due to the present of activity. M. The current literature review conclude that as standard analgesic drug19. Bapalal. anti-diarrhoeal and anti-diabetic activity. vitro models of inhibition of protein denaturation. & Nadkarni. B. Acetyl Salicylic acid was used as a turpethin. 1105. significant reduction in the fasting glucose level 3. Nadkarni. Ed. A. Tripathi. Diclofenac sodium was used far. K. Literature review observed comparison to the petroleum ether extract when that there is no clinical trials have been done so administered orally. The values were compared with Chaukhamba Bharti Publishers. 213-214 & 404. (2005). Vol II.. acrylamide may open new routes for exploring Analgesic Activity varies potential of the plant. Ed. A. 101-106. M. More research is It evaluated using tail flick method and acetic needed to isolate the various phytoconstituents acid induced writing response. Charakasamhita of was seen at the end of 21days20. K. Srikantha Murty. Popular Prakashan Ltd. Vol I. standard with an inhibition of 70% whereas it The presence of the resin glycoside and was 67. A. Varanasi India. The Ayurvedic Pharmacopoeia of India. Joy. "Medicinal plants. New Delhi (India). Bombay. and turpethum stem and roots described the effect of Baby P.. the plant Operculina Turpethum having high medicinal value and safe for medicinal uses. pp. K. Varanasi glibenclamide which was used as a standard. Vol I. Nadkarni. (2008). The above review reveals that the plant has Anti-Arthritic activity potent pharmacological activities. K. The chloroform present to get a clear idea of the mechanism of extract showed better dose dependent response in action of the plant. J. © Copyright reserved by IJPRS 85 . Agnivesha elaborated by Charaka & Drudhabala. Skaria. anti-microbial. Bhavprakasha of Bhavmishra. Bombay Popular Mumbai.. anti- Operculina turpethum was evaluated by the in- ulcer. weight. Chaukhamba Surbharti Publishers. (2007). The plant is traditionally claimed to possess The ethanolic root extracts in various purgative activity. The plant was found to have promising nephroprotective.22% in case of the ethanolic extract18. Government of India. 1st edn. Ministry of health and family welfare. K. 691-694 Figure 2: Plant uses 7. 131-965 5.. in his comparative study of the methanolic extracts of Operculina 1." Tropical the plant in streptozotocin induced diabetes in horticulture 2 (1998): 449-632. V.

S. 16. A. B. turpethum (syn. Kumar. A.. (2010). Alam. Operculina turpethum in serum lipid profile of male albino mice. (2007). R. M. S. G. M. M.. 1(8). 17. (2014). 12- Journal. 40. Sakila. Alam. Ipomoea turpethum). International Current Pharmaceutical effect of Operculina turpethum against 7. Pakistan Journal of Biological 18. & Alam. (2013). P. A Review on Phytopharmacological Activities of Operculina Turpethum Chaukhamba Shrikrishna Das. M. Asian Journal of 19. M. J. turpethum Linn. against paracetamol-induced hepatotoxicity in 20. H. Ghosh. Pulipaka.. P. Sujatha. In vitro Sciences. M. N. Sri. III. N.. 68(1). 302-312. M. S. antispasmodic and 11. Sadik... J. B. A. Shareef. M. (2013). O-b-D-Glucopyranoside from the ethanolic 2013.. Chaukhamba Surbharti Varanasi (India). turpethum by using swiss albino mice. S. World Alterations induced by N-Nitrosodimethyl- Journal of Pharmacy and Pharmaceutical amine and ethanolic root extract of Sciences. Narayanan. F. A. I. A. R. C. Analgesic activity of different solvent extract of Operculina 13. & Singh. 9 (2006): 1714. Comparative antidiabetic activity of Sciences. C. S.. Harun-or-Rashid.. Chemico- Biological Interactions. 5(5). dimethyl benz (a) anthracene induced © Copyright reserved by IJPRS 86 . Micropropagation and Biological Sciences 9.. rats. Kabir. Varanasi oxidative stress with reference to breast (India). Isolation turpethum Linn. antimicrobial activity of Operculina 1719. Sharma. & streptozotocin induced diabetic Balasubramanian. Pharmaceutical and Clinical Research. S. 1(9). R. Yasmin. Ignatius. bronchodilator activities of Operculina M. M. V. 14(1). M. International Journal of Advanced Research. (2012). V. Pakistan Journal of M. extracts and isolated compounds of Ipomoea turpethum. & 69-73. & Singh. Mondal. G. A. Vijayavel. Anantaram Sharma. Morphological variation of ten ipomoea Rahman. D. P. root extract of Operculina turpethum.22dien-3- Complementary and Alternative Medicine. Kowsalya.. V. cancer in experimental rats. (2012). M. Rizwani. H. 2008. Prabhavathi. 32. J. & Gilani.. 8. Vol. methanolic extract of Operculina turpethum stem and root against healthy and 14... M. 5(3). A. 215-8. N. S.. Watanabe... 597-599. an endangered medicinal plant. Indian Journal of Pharmaceutical (2012). no. Protective rats.. Subramanian. species of Bangladesh. N. of Maharshi Shushruta. and H. 168(3). 332-342... Jayachand. Sharmin. Anisuzzaman.. Asian Nagasudha. 5(3). S. & Rahman. 2(1). & Pingili. Kumar. B. A. Gafur. Sharma. 229-236. Shushruta Samhita 3(2). G.. M. V.. & Singh. Sravani. H. G. V. Ed. M. Antiulcer Activity of Indigenous Plant Operculina 10.. 258-259. Alam. 272-278. U. B. (2002).. K... Mandukhail.. Plant Omics. & Periyasamy. 15.. Khatun. Operculina turpethum Linn. Journal of Pharmaceutical and Clinical Protective effect of root extract of Research. Evidence-Based and Characterization of Stigma-5.. (2006). BMC Complementary and Antibacterial and cytotoxic activities of Alternative Medicine. B. antiarthritic and hemolysis preventive: membrane stabilizing efficacy of ethanolic 12. S. 9. root extract of Operculina turpethum.. 303-312. & Mishra. Studies on antidiarrhoeal.. Anbuselvam. H. A. (2013). A. Challa. 479. G. B. Syamala. R. Sharma..