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# 1. A cell has a voltage threshold of -75 mV (voltage value at which the action potential takes off).

Addition of a drug affecting voltage gated ion channels changes the voltage threshold value to -
80 mV. On addition of the drug, the voltage threshold is thus:
a. Depolarized
b. Hyperpolarized
c. No Change

2. A cell has a voltage threshold of -75 mV (voltage value at which the action potential takes off).
Addition of a drug affecting voltage gated ion channels changes the voltage threshold value to -
80 mV. On addition of the drug, the voltage threshold is thus:
a. More Depolarized
b. Less Depolarized
c. No Change

3. A cell has a voltage threshold of -75 mV (voltage value at which the action potential takes off).
Addition of a drug affecting voltage gated ion channels changes the voltage threshold value to -
80 mV. On addition of the drug, the voltage threshold is thus:
a. More Hyperpolarized
b. Less Hyperpolarized
c. No Change
4. A cell has a voltage threshold of -75 mV (voltage value at which the action potential takes off).
Addition of a drug affecting voltage gated ion channels changes the voltage threshold value to -
80 mV. The voltage threshold is thus hyperpolarized.

Assuming there is no change in the RMP (-90 mV) on addition of the drug, the cell has an:
a. Higher probability of firing an action potential
b. Lower probability of firing an action potential
c. No change in probability

5. A cell has a voltage threshold of -75 mV (voltage value at which the action potential takes off).
Addition of a drug affecting voltage gated ion channels changes the voltage threshold value to -
80 mV. The voltage threshold is thus hyperpolarized.

Assuming there is no change in the RMP (-90 mV) on addition of the drug, the cell is thus:

a. More excitable
b. Less excitable
c. No change in excitability

6. A cell has an RMP of -90 mV and a voltage threshold of -80 mV. Addition of a drug changes the
RMP to -85 mV, but has no effect on the voltage threshold. The drug thus:
a. Depolarizes the RMP
b. Hyperpolarizes the RMP
c. No change in RMP
7. A cell has an RMP of -90 mV and a voltage threshold of -80 mV. Addition of a drug changes the
RMP to -85 mV, but has no effect on the voltage threshold. The drug thus:
a. Increases the probability of firing an action potential
b. Decreases the probability of firing an action potential
c. No change in probability

8. A cell has an RMP of -90 mV and a voltage threshold of -80 mV. Addition of a drug changes the
RMP to -85 mV, but has no effect on the voltage threshold. The drug thus:
a. Increases the excitability of a cell
b. Decreases the excitability of a cell
c. No change in excitability

9. A cell has an RMP of -90 mV and a voltage threshold of -80 mV. Addition of a drug changes the
RMP to -95 mV, but has no effect on the voltage threshold. The drug thus:
a. Depolarizes the RMP
b. Hyperpolarizes the RMP
c. No change in RMP
10. A cell has an RMP of -90 mV and a voltage threshold of -80 mV. Addition of a drug changes the
RMP to -95 mV, but has no effect on the voltage threshold. The drug thus:
a. Increases the probability of firing an action potential
b. Decreases the probability of firing an action potential
c. No change in probability

11. A cell has an RMP of -90 mV and a voltage threshold of -80 mV. Addition of a drug changes the
RMP to -95 mV, but has no effect on the voltage threshold. The drug thus:
a. Increases the excitability of a cell
b. Decreases the excitability of a cell
c. No change in excitability

12. The voltage threshold at which the cell fires the action potential:
a. Is a fixed number like a physical constant
b. Is a dynamic property of the cell (can vary in a narrow range) based on the relative
interactions of Na and K permeabilities*

* Both voltage gated and leak Na and K permeabilities - although voltage gated sodium and leak
potassium permeabilities are the significant ones in this range.
13. Voltage gated Na channels activate at a voltage:
a. Equivalent to the voltage threshold for action potential firing
b. Depolarized to the voltage threshold for action potential firing
c. Hyperpolarized to the voltage threshold for action potential firing

14. All else being equal, as compared to control, increasing voltage gated sodium channel density in
a cell would _____________ the voltage threshold for action potential generation
a. Depolarize
b. Hyperpolarize
c. Not affect

15. All else being equal, as compared to control, increasing voltage gated sodium channel density in
a cell would hyperpolarize the voltage threshold for action potential generation. Since the RMP
does not change in this case, the cell has an:
a. Increased probability of firing an action potential
b. Decreased probability of firing an action potential
c. No change in probability
16. All else being equal, as compared to control, increasing voltage gated sodium channel density in
a cell would hyperpolarize the voltage threshold for action potential generation. Since the RMP
does not change in this case, the cell is thus:
a. More excitable
b. Less excitable
c. No change in excitability