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(RAS)

(RAS) ,
. , ,
- 1 . RAS
, 2% 66% 2 .
aphthae 3 2,24%,
2%
Crivelli 4 .
(1,1%) 5 .
RAS ,

. RAS
Behcet,
, , Crohn 6 .
.
( 1 cm ) . RAS
, RAS. ,
, ,
, ,
. 3 ,
herpetiform. , 80% 90%
. , RAS ,
.
7 .
,
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.,
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,

.
:
aphthai
(460-370 ..). , ,
,
8 .
RAS? , ,
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etiopathogenic .
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.
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2 .
,
(egcheese ), , ,
, , HIV . , ,
7 . ,
: , , ,
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. RAS 10 19 .
, '
, , sex-, . RAS
, 40% RAS
ulceration.There likehood
RAS . 2 , 11 ,
HLA B 12 HLADr 2 .
haematinic (, 12) ,
, HIV 9 .
:
,

. RAS ,
.
, , , , ,
.

RAS.



. ,
, hemidesmosome
.
. , ,
, RAS

.


. IL -2, ,
mRNAs RAS,
. IL-10 mRNA RAS
IL-10 mRNA RAS
.
, IL-10
, RAS 10 .
, Bazrafshani .. 11 (IL-1 , IL-
1B, IL-1RN IL-6 ),
RAS. G IL-1B -511
RAS, G / G .


, .
, estabilish RAS,
Streptococcus Helicobacter pylori
RAS 12, 13 . ,
D (GtfD), RAS,
.
Streptococcus sanguis,
, . ,
RAS amang,
.Helicobacter pylori
PCR 72% RAS.

. RAS ,
RNA
RAS 14 .
6 (HHV-6), Ebstein-Barr RAS ,
.

(HCMV), (VZV) RAS 15 .

RAS .
,
.
.
, , ,
. multispecialty
.

. ,
, ,
16 . RAS
.
,
. RAS , -
,
, , .
.

. RAS
.
, ,

,
17 .
RAS ,
, herpetiform .
, 80% 90% .
,
1: 3 . 5 mm

- .
, 1-5
. 1 2 ,
.
aphthous , 10%
, (> 1 cm), ,
. crateriform, ,
.
.
, , ,
.
HIV AIDS,
.
Herpetiform 10%
. ,
.
gingivostomatitis . , -
, herpetiform keratinized
gingivostomatitis . Herpetiform
(1-2 mm), , ,
7 10 .
herpetiform , ,
18 .

RAS,
. : , ,
.
,

. RAS
Behcet, Sweet,
, , ,
, ,
Crohn 19- 25 . aphthosis,
(MAGIC) , Marshall PFAPA (
, , , adenitis)

RAS 26, 27 .
, .
, .
-
(HIV) 28 . -
, Lesch-Nyhan,
.
.

(RAS)
.

.
1 ,
. ,

. HSV
.
keratinized ,
, , 29 .
(HSV)
. , HSV ,
, ,
, , .
, 30 .

1 mm .
( ) 1-2
.
15 mm . ,
2 . ,
. 8-10
. 7-10

.
, , ,
, .
2 .
.
, aphthous
, .
' ,
29 . 1
RAS.
RAS

.
.
gingivostomatitis
. ( aphthous
) .
, HSV
, up-to-
.

1:
(RAS).
RAS



, ( )

, ,
, , , ,

1-3 1-2

.
.
(HSV) . - (VZV)
, . Epstein-Barr (EBV) ,
(HL).
6 (HHV 6)
31 .
.
Behcet.
Behcet ,
,
, , , .
Behcet .
, ,
, .

, , 1 10 000.
,
. HLA-BW51
,
Behcet 19%.

20 .
, ,
, ,
, pathergy, Behcet 32 .


. , ,
. , gingiviris, ,
.

33 .
disapparence

3 . neutrophenic , , ,
, 25, 33 .


. ,
, , ()
. RAS ,
, .

. RAS
.
, , ,
, ,
34, 35 .
( , , flucinonide, ,
-17 , , )
RAS 36 . ,

symptoms.Additionally, , ( ., Orophaynx),
, ,
. Decadron () 0,5 mg / 5 ml
. (benzocaine 20%)
. amlexanox, ,
, ,
.
RAS
, - , 5-
2 9, 34, 37,38 .
, .
RAS
37,39 .
RAS

. , , , ,
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37 .
. ,

, .

RAS .
. Fontes et al 9,40
54 .
1 1,5 mg / d 3
.
, ,
.
RAS ,

.
RAS,
41 .
, , ,
.
-
.
- (TNF)
RNA .
.
Behcet,
.
(HIV)?
. , ,
. ,
,
42, 43 .
hematinicdeficiency benefid
. widerange ,
44 .


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