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Go Geous - beneficial drink that will definitely

awaken even the most weakest of cells.


This exquisite product brings to you the secrets
of the future so advanced that its formula cannot
be compared to any other existing health
supplement in the market.

Highly efficacious and balanced formulation consist of :

PhytoCellTec™ Malus Domestica (Apple Stem Cells),


Rousselot Fish Collagen,
Acai Berry Extract,
Pine Bark Extract,
Grape Seed Extract,
L-Arginine and Mixed Berries.
Uttwiler Spätlauber (Malus Domestica)- an Apple with an
Excellent Storage Ability

• Storage ability of apples was an


important factor to guarantee fresh
fruits over winter in the 18th
century
• Modern apple cultivars are selected
for a sweet flavour and therefore the
Uttwiler Spätlauber disappeared
• Today the Uttwiler Spätlauber apple
is an endangered apple variety with
only a few trees left in the world
The Secret of Storage Ability

• Longevity of cells
• High acid and tannin concentrations
• Undiscovered metabolites?
Young and Old
Plant Cell Culture Technology (PCT)

• PCT makes it possible to cultivate cells


of endangered and rare species
• The technology is based on
dedifferentiated plant cells
• These cells are plant stem cells and can
be cultivated in liquid systems
What are Stem Cells?

• Stem cells have two properties:


Self-renewal - the ability to go through
numerous cycles of cell division in an
undifferentiated state
Differentiation - the capacity to
differentiate into other cell types

• Toti-, pluri-, multi-, unipotent stem cells


Human: Embryonic Stem Cells (Pluripotent)

• Cells derived from the inner cell


mass of an early stage embryo
• Blastocyst, 4-5 days post
fertilization, 50-150 cells
• Pluripotent: Differentiate into one of
the more than 220 different cell
types of an adult body
• The use of embryonic stem cells in
medicine is discussed
controversially
Human: Adult Stem Cells (Multipotent)

• Undifferentiated cells among


differentiated cells in a tissue or
organ
• Generate all the cell types of the
organ from which they originate —
potentially regenerating the entire
organ from a few cells
• Primary roles: Replenish dying cells
and regenerate damaged tissues
Plant Stem Cells
Formation of Callus Tissue

• If a plant is wounded, a callus tissue is


formed (wound healing tissue)
• In the callus tissue the normal
differentiated cells go back into a
dedifferentiated form and become stem
cells (not possible in humans)
• Mechanism is controlled by different
plant hormones (auxins)
PhytoCellTecTM by Mibelle Biochemistry

• PhytoCellTecTM utilizes this unique totipotency of plant cells


• Only a small quantity of plant material of endangered species is
needed
• Induction of callus tissue by cutting plant parts
• Isolation of stem cells and cultivation on agar plates
From Callus to Plants
PhytoCellTecTM

• Complete dedifferentiation of the cells into a homogenous culture (4 -12


months)
• Transformation of the cells into liquid suspension
(1 - 6 months)
• Find optimal conditions for cell cultivation
(1 - 6 months)
Stem Cells and Aging

• Stem cells are responsible for the rejuvenation


• Stem cells are sensitive to environmental threats
• Chronological aging leads to the depletion of the number and activity of
stem cells

 Protection of stem cells and activation of stem cell function is of great


importance in our body
Epigenetic Factors in Stem Cells

• Normal differentiated cells express only a limited amount of genes


(fibroblast: collagen; blood cells: hemoglobin)
• Stem cells have the possibility to express the whole DNA
• The epigenetic profile regulates the gene expression in stem cells
Activity of PCT Malus Domestica

1. Use of plant stem cells to protect stem cells

The components of Malus domestica stem cells are rich in epigenetic


factors relevant to protect and maintain the function of skin stem
cells.

2. Use of plant metabolites to delay senescence

The active ingredients of Malus domestica var. Uttwiler Spätlauber


cells contain metabolites which insure longevity of cells.
Study Results
Increase in Cell Number (Human Umbilical Cord Stem Cells)
Malus Domestica stem cell extract

1.40E+ 05

1.20E+ 05

1.00E+ 05
Cell number

8.00E+ 04

6.00E+ 04

4.00E+ 04

2.00E+ 04

0.00E+ 00
Control 0.01% 0.1%
Protection Against UV
(Umbilical Cord Stem Cells)
Malus Domest ica st em cell ext ract

Control 0.01% 0.1%


0
Decrease of t he living cell number in %

-10

-20

-30

-40

-50
Growth of Hair Follicle

Hair follicles From human skin fragments


(from micro dissection)

Test substance PhytoCellTecTM Malus Domestica 0.2%

Design Length of hair follicle increases until day 14


→ after day 14 induction of senescence
→ length of hair follicle decreases

Day 0 Day 4 Day 7


Length of Hair Follicle

Control 0.2% Malus Domestica stem cell extract

20

10
Change in length compared to day 14 in %

-10

-20

-30

-40

-50

-60 Senescence of hair


-70
(stem cells) can be delayed
Day 16 Day 18 Day 20
PhytoCellTecTM Malus Domestica
Effect on Gene Expression in Senescent
Dermal Fibroblasts

Cell line Normal Human Dermal Fibroblasts

Design  H2O2 induced senescence (2h)


followed by a treatment with
2% PhytoCellTecTM Malus
Domestica or not (144 h)

Parameters  Gene profile (microarray)


PhytoCellTecTM Malus Domestica
Gene Profile (Microarray)

↓ Gen, that is down-regulated by senescence induction (see control)

↑ Gen, that is up-regulated or normalized in senescent cells by PhytoCellTec Malus Domestica

Gen After H2O2 After H2O2


Control + 2% Malus Domestica
stem cell extract
cyclin B1: induces proliferation 73 ↓ 130 ↑
cyclin E1: tumor inducer 78 ↓ 135 ↑
p53: tumor suppressor gene 63 ↓ 137 ↑
insulin-like growth factor II: cell proliferation enhancer 71 ↓ 117 ↑
heme oxigenase 1: antioxidans enzyme 89 ↓ 211 ↑
Summary

Product from rare Swiss Malus domestica var. Uttwiler Spätlauber


PhytoCellTecTM to produce stem cells from this apple

Product activity
1. Activation and protection of stem cells
2. Delay of senescence

Results show
• Protection of stem cells against UV-radiation
• Increase of activity of stem cells
• Decrease of senescence markers in fibroblasts
• Increase of life span of hair follicles
Claims

• Delays senescence of essential cells


• Protects longevity of stem cells
• Protection of stem cells
• Rejuvenation of cells
• Maintains the power of regeneration
• Combats chronological aging
Properties of PhytoCellTecTM

• PhytoCellTecTM is a preparation of plant stem cells


• PhytoCellTecTM is produced in Switzerland by a
novel plant cell culture technology
• PhytoCellTecTM contains plant stem cells to protect
and maintain stem cells
• The protection of stem cells is a breakthrough
approach in anti-aging
• Studies showed that PhytoCellTecTM protects human
stem cells and rejuvenates them
• PhytoCellTecTM delays chronological aging
PhytoCellTec™ Malus Demestica -
Benefits
• PhytoCellTecTM plant stem cells are a
breakthrough in anti-aging therapy
• Stem cell treatment is a revolutionary new
approach in healthcare industry
• Plant stem cells are extremely efficient but
also safe to use
• PhytoCellTecTM is based on real plant
stem cells to trigger the rejuvenation of the
body
• PhytoCellTecTM delays the natural aging
process by maintaining the activity of stem
cells
According to the US
edition of Vogue, the First
Lady buys a £215 serum
which uses an extract
from stem cells of the
Uttwiller Spattauber
apple
Rousselot™ Fish Hydrolyzed Collagen

Rousselot™ Hydrolyzed Collagen are natural proteins,


derived from the collagen found in fish skins and bones.

Some definitions of Collagen

Chemistry and Biology of proteins-


Merriam Webster Dictionary F.Haurowitz
Academic Press, Inc. – New York,1950
“…an insoluble fibrous protein
that occurs in vertebrates as the “…a structural protein of connective tissues
chief constituent of connective and composes the larger part of the
tissue fibrils and in bones… tendons, ligaments…(and)… a portion of
the bones, cartilage and skins..”
Rousselot™ Fish Hydrolyzed Collagen
Rousselot™ Hydrolyzed Collagen is 92% pure protein made of all
essential amino-acids, particularly rich in alanine, arginine, glycine,
glutamic acid and proline.

Alanine*: Involved in the supply of energy to muscle tissues, brain and central
nervous system, alanine plays a role in the metabolism of sugars and organic
acids. It strengthens the immune system through its effect on antibody
production.

Arginine*: Useful for immune system stimulation, arginine is involved in the


wound healing process and the secretion of hormones.
Rousselot™ Fish Hydrolyzed Collagen

Glutamic Acid*: An important excitatory neurotransmitter, glutamic acid helps


speed the healing of ulcers and gives relief from fatigue.

Glycine*: Beside its nutrient role for a strong immune system, glycine triggers
the release of the oxygen required by the cell-making process. It is also a fast
inhibitory neurotransmitter.

Proline*: Important for joints and tendons adequate functioning, proline


participates in heart muscle strengthening.

*Non-essential amino-acid.
Rousselot™ Fish Hydrolyzed Collagen – Clinical
Studies
Comprehensive clinical studies carried out in Japan and France confirm the effect of
taking Rousselot™ Hydrolyzed Collagen on skin health.

Background :

Fine lines, wrinkles, and loss of elasticity are symptoms commonly associated with
aging skin. Accumulated environmental
exposure and a natural decrease in cell renewal contribute to other signs less often
associated with aging: dull, rough, or dry skin.

The latest investigative studies using state-of-the-art technology have challenged the effect of
Rousselot™ Hydrolyzed Collagen. Two clinical studies were carried out by global independent
skin health research organizations having a well
proven approach for verifying product performance claims. Mechanical measurements and
volunteers were assessed by certified skin experts.
Rousselot™ Fish Hydrolyzed Collagen – Clinical
Studies
Conclusion

These two clinical studies demonstrated the benefits of Rousselot™ on skin health.
Taken daily, up to 12 weeks, the results verify that regular intake of Rousslet™ Hydrolyzed
Collagen improves the basic skin condition and structure.
Rousslet™ Hydrolyzed Collagen has clinically shown to:
Improve skin moisture level
Improve skin smoothness by reducing the number of micro-relief furrows
Prevent the formation of deep-wrinkles
Improve skin suppleness

Rousslet™ Hydrolyzed Collagen, a completely characterized and scientifically


objectivized natural bioactive ingredient that improves epidermis moisture content and
prevents skin aging.
Acai Berry
The Acai (ah-sigh-ee) Berry has been around for thousands of years
and not until the 1990's was it introduced to the western world. The
acai berry was found to possess tremendous health properties. The
acai berry was first used by the tribes of the Amazon jungle as a
cure for various ailments.

The acai berry was discovered to have natural antioxidant properties,


as well as being a natural cholesterol controller. When eaten it helps
reduce the bad cholesterol in our blood and increases the good
cholesterol. The tribes of the Amazon knew of these properties and
found out that it helped build the immune system, fight infection,
protect the heart, and control prostate enlargement (nature's viagra).
It was a great energy food for the tribes-people.
Acai Berry - Benefits
• A remarkable concentration of antioxidants that help combat premature
aging, with 10 times more antioxidants than red grapes and 10 to 30 times
the anthocyanins of red wine.

• An almost perfect essential amino acid complex in conjunction with valuable


trace minerals, vital to proper muscle contraction and regeneration.

• The fatty acid content in açaí resembles that of olive oil, and is rich in
monounsaturated oleic acid. Oleic acid is important for a number of reasons:

• It helps omega-3 fish oils penetrate the cell membrane; together they help make
cell membranes more supple. By keeping the cell membrane supple, all
hormones, neurotransmitter and insulin receptors function more efficiently. This is
particularly important because high insulin levels create an inflammatory state,
and we know, inflammation causes aging.

• Acai Berry does contain Omega-3 fatty acids, Omega-6 and Omega-9. Each
of these can lower the so-called bad cholesterol, or LDL, and each can
maintain our HDL, or good cholesterol.
Acai Berry – Other Benefits
Weight loss - Increases the metabolism in the body, which helps in reducing
the unwanted fats from the body.
Increases Energy- Our active lifestyles leave us drained of energy. Many of us
don’t get enough sleep, and we walk around all day like zombies. This creates
serious long-term medical conditions. Thankfully, Acai Berry helps improve your
overall energy. You can rest better, and wake up more refreshed in the morning.

Improves Blood Flow- Poor circulation can lead to numerous medical


conditions (clotting, balding, and heart issues.) Acai Berry supplements work to
improve your blood flow, thus staving off many serious ailments. Improved
circulation makes you feel better and live longer.

Healthier Skin- The berry contains many unique properties that work to make your
skin look and feel younger.
Acai Berry – Other Benefits
Stronger Heart- Heart disease is one of the leading causes of death in America. From
lack of exercise to poor dietary habits, our hearts endure a lot of stress. Acai Berry
supplements give your heart the nutrients it needs to work properly.
Better Concentration- Another of the seemingly endless benefits of Acai Berry is
the improved mental clarity it produces. In a way, this goes back to the circulation
benefits. With better blood flow, your brain is able to operate more efficiently.
Reduced Cholesterol- When you think of lowering your cholesterol, you probably
recall images of eating healthy foods that taste terrible. Acai Berry supplements
save you the trouble of eating tasteless oats. This berry will lower your cholesterol
significantly over time.
Detoxifies Body- Acai Berry contains several antioxidants that work to eliminate
harmful substances from your body. Throughout our life, our body absorbs many
damaging substances. Acai Berry works to eradicate them, and to make your
immune system stronger than ever before.
Enhances Sexual Performance- Known as Viagra of Amazon
Pine Bark Extract

Pine bark extract is made from the bark of a European


coastal pine tree called the Landes or maritime pine,
whose scientific name is Pinus maritima.

Researchers have termed the group of


antioxidants found in pine bark extract oligomeric
proanthocyanidins, or OPCs for short. OPCs (also
referred to as PCOs) are some of the most
powerful antioxidants available.
Pine Bark Extract
Antioxidants play a key role of repairing and protecting cells in the body. They
help protect against free radicals, which are damaging byproducts of metabolism
and exposure to environmental pollutants. Free radical damage is believed to
contribute to aging, as well as too severe conditions including heart disease and
cancer.

Much research has been conducted on OPCs and on pine bark extract. In France,
pine bark extract and OPCs have been rigorously tested for safety and
effectiveness, and pine bark extract is a registered drug.
Pine Bark Extract
Pine bark extract has been shown to contain a powerful antioxidant that helps
protect cells from free radical damage and increases the effectiveness of vitamin C.

Pine bark extract has been shown to help lower cholesterol, and to decrease the risk
and severity of atherosclerosis, or damage to the arteries. It has been demonstrated
to help strengthen and repair tissues made of collagen, a protein that builds blood
vessels, skin, and connective tissue.

The OPCs in pine bark extract have also been shown to help reduce swelling and
inflammation in the body.
Pine Bark Extract - Benefits
Pine bark extract is used to reduce the risk and severity of heart
disease, strokes, high cholesterol, and circulation problems.

It is used in the nutritional treatment of varicose veins and oedema,


which is swelling in the body due to fluid retention and leakage of
blood vessels.

Arthritis and inflammation have also been improved in studies using


pine bark extract, as well as the uncomfortable symptoms of PMS and
menopause.
Pine Bark Extract - Benefits
The OPCs in pine bark extract are recommended for various eye
conditions that are caused by blood vessel damage, such as diabetic
retinopathy and macular degeneration.

Pine bark extract is recommended to improve the health and


smoothness of the skin, including damage caused by overexposure
to sunlight.

Pine bark extract is a supplement used for anti-aging and preventive


care as well.
Grape Seed Extract

Grape Seed Extract (GSE) is a natural plant


constituent (bioflavonoid) which strengthens and
protects living tissue. The Oligomeric
Proanthocyanidins (OPC) components in GSE are
50 times stronger than Vitamin E and 20 times
stronger than Vitamin C.

Grape Seed Extract is an antiallergenic,


antihistamine, anti-inflammatory, and antioxidant.
It strengthens blood vessels, improves skin, and
aids in circulation.
Grape Seed Extract

Grape Seed Extract is prescribed by doctors in several


European countries for the prevention and treatment of a
variety of health problems including cardiovascular
disease, varicose veins, water retention, collagen damage
and arthritis. Because it is used pharmaceutically, it has
undergone a tremendous amount of testing.

Grape Seed Extract is an extraordinarily safe and effective


nutritional supplement.
Grape Seed Extract

Grape Seed Extract provides cardiovascular protection by


preventing oxidation of lipoproteins (LDL), making them less
likely to stick to blood-vessel walls.

It also makes the linings of the arteries more resistant to damage


and helps control excessive clotting.

GSE strengthens the capillaries ensuring a good supply of oxygen


and nutrients to the brain and throughout the body. It also affects
enzymes that influence blood-fluid balances and therefore may be
helpful in lowering blood pressure.
Grape Seed Extract - Benefits

Below are some health benefits of grape seed extract:

* Grape seed extract is one of the most powerful antioxidants that fights free
radicals

* Grape seed extract is 20 times more potent than Vitamin C and 50 times stronger than Vitamin
E

* Grape seed extract helps improve cardiovascular health

* It also helps promote brain, skin and eye health

* Grape seed extract is also anti-bacterial, anti-viral, and anti-inflammatory


Grape Seed Extract - Benefits
* Grape seed extract is one of the few antioxidants that can penetrate the blood
brain barrier to help protect the brain and nerve tissue

* Some studies have also shown grape seed extract to prevent the formation of
plaque in the arteries

* It can also improve mental alertness and help prevent senility

Recently, researchers discovered that Grape Seed Extract


can help to stimulate healthy hair growth by defeating the
hormone dihydrotestosterone (DHT) that stops the hair
follicle growth cycle.
L - Arginine

L-Arginine Could Be A Magic Bullet In Anti-Aging Arsenal

Columbia University refers to L-arginine as the "magic bullet" for the


cardiovascular system

Properties of L-arginine were validated by the 1998 Nobel Prize in Medicine, and
since then have created a frenzy of interest in the Pharmaceutical and Nutraceutical
fields.

Medical researchers have gathered enough clinical evidence to bring L-arginine to


the forefront of modern medicine as an accepted treatment for a variety of human
ailments. The L-arginine phenomen is changing standard treatment methodologies in
heart disease, immune function, adiposity-generated diseases, genetic growth
deficiencies, high blood pressure, sexual disfunction, and human aging.
L – Arginine - Benefits
The efficacy of L-arginine as a therapeutic agent has been validated
by thousands of clinical studies.

The benefits and functions attributed to oral ingestion of L-arginine


include:

• Precursor for the synthesis of Nitric Oxide (NO)


• Stimulation of the release of the most important anti-aging
hormone in the body; growth hormone.
• Improves immune function
L – Arginine - Benefits
• Reduces risk of heart disease

• Natural Alternative to Viagra

• Increases muscle mass

• Reduces adipose tissue body fat

• Helps improve insulin sensitivity

• Helps decrease blood pressure

• Alleviates male infertility, improving sperm production and motility


L – Arginine - Obesity
Obesity is characterized by increased levels of insulin (high glycemic foods and
drinks) and by subnormal growth hormone (GH) release.
Insulin promotes fat and carbohydrate storage while GH stimulates lipolysis (fat-
burning). The insulin/growth hormone ratio is significantly higher in obese
humans than in lean humans.

The combination of high insulin and low GH exacerbates the obese condition. L-
arginine is the main oral agent responsible for restoration of GH in humans, and
administration of L-arginine taken at bedtime on an empty stomach 30 minutes
prior to Delta sleep reinstates normal GH levels.
Mixed Berries – Strawberry, Bilberry, Raspberry,
Elderberry, Blackcurrant, Red Beet

They’re loaded with fiber, which helps you feel full (and eat less).
Mixed Berries – Strawberry, Bilberry, Raspberry,
Elderberry, Blackcurrant, Red Beet

Top the charts in antioxidant power, protecting your body


against inflammation and free radicals, molecules that can
damage cells and organs.

A recent study even showed that one-half to one cup of mixed


berries a day improved cognition and motor performance in
animals.
Mixed Berries – Strawberry, Bilberry, Raspberry,
Elderberry, Blackcurrant, Red Beet

James Joseph, PhD, director of the Neuroscience Lab at the


United States Department of Agriculture Human Nutrition
Research Center on Aging at Tufts University, Boston, which
conducted the study, notes that we become more susceptible to
the damaging effects of free radicals and inflammation as we
age.

Berries help prevent those effects by turning off the


inflammation signals triggered by cytokines and COX-2s,
making them an ideal part of your diet

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