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OBESITY

Abnormal
Adipocyte Overload
Central Obesity
Adiponectin

Leptin

Sympathetic Nervous
Systemic oxidative stress Metalloproteinases Joint Compressive
System
Force
Circulating IGF-1
Renin Angiotensin Aldosterone Degranulation products
System activation
Inflammatory mediator
Damaging lipid in Bruch
Membrane Testosterone

Vascular endothelial growth Systemic low-grade Local low-grade


factor (VEGF) inflammation inflammation

Choroidal Neovascular
Renal Na+ Reabsorption Prostate
Cancer

Age Related Macula Knee Osteoarthritis


Hypertension Tendinopathy
Degenerative