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Which molecule below can act as methyl donor?

A. *

B.

C.

D.

E.

Drug elimination can be through, except...

a. with bile
b. through lungs

c. through skin*

d. through intestine

e. through salivary glands

The dose and the frequency of administration required to achieve effective therapeutic
blood and tissue levels vary in different patients because of individual differences in drug
distribution and rates of drug metabolism and elimination. These differences are
determined by genetic and non genetic factors, except..

a. Liver size
b. Circadian rhythm
c. Liver function
d. Body temperature
e. Concomitant exposure to drug metabolisms inducers or inhibitors

In phase II metabolism, isoniazid undergoes...

a. Methylation reaction
b. Acetylation reaction *
c. Sulfatation reaction
d. Bioactivation
e. Substitution reaction

How can some drugs become an inhibitors to some enzyme when metabolism occur in
our body?

A. Drugs release its active substance to make an therauphetic effect. So, these
substance would attach to a enzyme.
B. Enzyme would be destroyed by the effect of drugs
C. Drugs would bound with an enzyme and then its compound cant attach to a
any reseptor.

D. If a drug have a same ultilize with another enzyme, they would


competed to be the first that attach with reseptors.

Substance of drug is eliminated through the intestine, except...

a. Ftalasol
b. Enteroseptol
c. Magnesium sulfate
d. Tetracyclines

Drug are conjugated with the help of acetyl coA..

a. Sulfonamides*
b. Chloramphenicol
c. Adrenal
d. Barbiturates
e. Trimethoprim

Drug can eliminate and become various elimination of drug by its elimination way. This
following answers are the elimination of drug except

a. Through lung gases and volatile substances: Camphor, iodine, ethanol


b. Through intestine: antibiotic of tetracycline groups. *
c. Through bronchial, salivary glands: bromides, iodides.
d. Through sweat glands: bromides, iodidides, salicylites.
e. With milk get into organism of baby: levomyceti, fenilin, reserpin, tetracyclines,
sulfonamides.
What are the reaction types of liver pathology factors that influence on drug metabolism?
Except

a. Decreasing of excretion speed of drug


b. Not depending on their kinetics*
c. Type and stage of liver disease
d. Increasing of bioavailability
e. Decreasing of excretion speed of orally administered drugs with high hepatic
clearance

The answer below are type of enzyme-inducing drugs, except

a) sedative-hypnotics
b) convulsant*
c) tranquilizers
d) anticonvulsants
e) insecticides

Examples of drugs undergoing a hydrolysis process at the time of phase 1


biotransformation are..

a. Diazepam
b. Chlozepid
c. Novocain*
d. Rifampicin

When excretion through kidney there filtration stage. What will happened if there
disorders in filtration stage?
a. Decreasing of blood circulation and hydrostatic pressure of blood plasma in
glomerular capillaries that cause shock
b. Decreasing of blood circulation and hydrostatic pressure of blood plasma in
glomerular capillaries that cause shock and collapse
c. Increasing of blood circulation and hydrostatic pressure of blood plasma in
glomerular capillaries that cause collapse and death
d. Increasing of blood circulation and hydrostatic pressure of blood plasma in
glomerular capillaries that cause death

The response to the drug varies from one individual to another, since this variation usually
has Gaussian variation. In the distribution it is assumed that the determinant of the
response is multi-factorial. However, some drug responses indicate discontinuous
variation and in these cases the population can be divided into 2 groups or more. The
statement concerns the biotransformation factor based on ...

A. Genetic polymorphism*
B. Exposure pollutant coming from the environment
C. Pathological Status
D. Age
E. Gender

Antibacterial that can cause contraindicated during lactation is

a. Amantadine
b. Zidovudin
c. Nalidixic acid *
d. Cyclosporine

A drug that could inhibit one isoenzyme while being a substrate for another isoenzyme
is...
a. Quinidine*
b. Barbiturate
c. Isoniazid
d. Ciprofloxacin
e. Omeperazole

Below that is an example of a drug that has conjugated with sulfate is ...

a. Isadrin*
b. Sulfonamides
c. Nicotine acid
d. Isoniasid
e. Noradrenaline

In ribonucleoside or nucleotide synthesis, they carried on the activation of many and


antimetabolites that used in cancer chemotherapy. Activation that carried on are

A. Purin and pyrimidine*


B. Purin and adrenaline
C. Histamine and pyrimidine
D. All of the answer are incorrect
E. Adrenaline and histamine

The following are not the drugs that are reduced in I phase !

a. Rifampicin
b. Hestagens
c. Metronidazol
d. Nitrazepam
e. Levomycetin
which drug undergoes a methylation process at second phase biotransformation?

a. Sulfonamides
b. Paracetamol
c. Morphin *
d. Isadrin
e. Levomycetin

Substrates may induce microsomal enzymes and may also competitively inhibit
metabolism simultaneously, if

A. Substrates bound the lipid membrane of the endoplasmic reticulum


B. Bound the drugs
C. Substrates out of the endoplasmic reticulum
D. Substrates does not bind
E. Substrates bind to a particular enzyme

which drug undergoes oxidation biotransformation in phase 1 ?

a. Diazepam*
b. Paracetamol
c. Ditilin
d. Cocain
e. Novocain

Pregnant women should not take isoniazid medication because of the ....

a. Isoniazid is a hard drug


b. Isoniazid can be metabolized to acetyl isoniazid which is toxic
c. Isoniazid may inhibit fetal growth
d. Isoniazid can trigger a miscarriage
e. Isoniazid has side effects that can harm the fetus
Compounds having amino or hydrazine residues are conjugated with the help of acetyl
CoA is the definition of?

a) Metabolites
b) Drugs
c) Pesticides
d) Acetylation
e) Proteins

Bellow the right pathway of systemic circulation, is

a. Nonionic diffusion drug metabolized small intestine carrier-mediated


transport
b. Hepatic portal system drug metabolized cell bladder carrier-mediated
transport
c. Carrier-mediated transport small intestine nonionic diffusion
d. Carrier-mediated transport drug metabolized call bladder excreted

Answer: c. Carrier-mediated transport small intestine nonionic diffusion

Below are drugs that undergoes metabolism in the intestinal wall with the help of
intestinal bacteria is

a. Penicillin
b. Isadrin
c. Levodopa*
d. Hydrlalasin
e. Aminazin

The change of active drug into an active metabolite on biotransformation, causing


changes in pharmacological effects of the drug, one example of the change is ....
a. Phenacetin becomes paracetamol
b. Diazepam becomes nordiazepam
c. Digitoxin becomes digoxin
d. Iproniazid becomes isoniazid *
e. Levodopa becomes dopamine

Drugs can be excreted in forms of metabolites through, except....

a. kidney
b. liver
c. lungs, intestines
d. sweat, mammary glands
e. skin*

Substance of drug is eliminated through lungs

a. Salicylates
b. Magnesium Sulfat
c. Meprotan
d. Ftorotan
e. Fenilin

Drug glucuronides, excreted in bile, can be hydrolyzed in the gut by

*Bacteria

Virus

Fungi

Protozoa

Rickettsiae
The following class of drugs that can inducing the action of enzymes , except?

a. Sedative-hypnotics
b. Anticonvulsants
c. Insecticides
d. Analgetic*
e. Transquilizers

What is the effect of nutrition character on drugs metabolism?


A. Decreasing of metabolisme speed in case of heavy digestice disorderslinked
with starvation
B. Increasing of metabolism speed
C. Increasing of bioavailability
D. Increasing of metabolism speed if in contact with chlorine insecticides
E. Stimulation and depression of enzyme reaction

Conversion of Phenobarbitone to P-Hydroxyphenobarbitone is the biotransformation


function as....

a. Pharmacological Inactivation.*
b. Bioactivation.
c. Toxicological Activation.
d. Lethal Synthesis.
e. Biotransformation.

Below is an example of an enzyme inhibitor, except...


a. Omeprazole
b. Sulfonamides
c. Ciprofloxacin
d. Maltose*
e. Isoniazide
Which one is enzyme inhibitors?

a. Phenobarbitone
b. Rifampicin
c. Glucocorticoide
d. Metronidazole*
e. Propanolol

A drug that metabolized with nonspesific enzymes is...


A. Hydrlalasin

*B. Pencillin

C. Levodopa

D. Isadrin

E. Methotrexat

Glucoronide conjugation is most important reaction in drugs. This reaction occurs in


compound with...group within glucoronic acid and excreted in.... Example of drugs....
a. Hydroxyl-Liver-Paracetamol
b. Amine-Intestinal-Aspirin
*c. Carboxylic acid-Bile-Chloramphenicol
d. Phenol-Liver-Morphine

Which one is the factors that can affect the speed of drugs metabolism?

a. Alcohol one time consumption


b. Alcohol chronic consumption
c. Smoking
d. Pregnancy
e. Time of introduction of drugs
A chronic consumption of alcohol has an influence on drug metabolism, which is

a. Increasing metabolism of certain drugs


b. Depressing of enzymes that metabolize drugs
c. Induction of enzyme system *
d. Decreasing of excretion speed of drugs
e. Toxicological activation