Pathophysiology of Osteoarthritis

Age, Hereditary

Advancing Loss of Cartilage

Diet, Obesity, Nature of Narrowing of joint spaces

Pinch/crowd nerve

Formation of Osteocytes


Decrease in synovial fluid

Pressure between joint

Obliteration of joint space

Degeneration of cartilage


Continuous use of joint

Difficulty of movement Formation of subchondral cysts

Disappearing of full thickness of articular cartilage Wear and tear of articular cartilage Release of chemical mediators

Hardening of the underlying bone

Inflammatory response Immobilization Repair and remodelling

Acts on pain receptors

Increase blood flow

Increase vascular permeablity


Redness, increase WBC



Surgery, Celt & stem cell injection

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