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Legend: Precipitating Factors:

Entry of pathogen to skin impairment; such as

fissure, cut, laceration, insect bite, punctured
wound or severe athletes foots (likely caused by
Streptococcus pyogenes and Staphylococcus
Signs and

Patient is an engineer and a football player

that requires particular footwear

Fungal infection in the skin results to

Athletes foot

Severe infection causes damage skin and

became infected by S. pyogenes and S.
aureus causes Cellulitis

Infection and trigger of inflammatory


Release of chemical mediators

Migration of neutrophils and

Release of chemokines and cytokines WBC attack and destroy
Pain Production of prostaglandins macrophages to phagocytize
through immune-inflammatory response the organism
the bacteria

Detected by the hypothalumus Vasodilation with increased capillary

permeability and leakage of plasma into Increased blood
surrounding tissue flow and leakage
Increased in temperature

Redness, hot, swelling

Fever of nerves