BRS Pharm
1. abciximab: antibody against glycoprotein 2b/3a receptor
2. abciximab: prevents platelet activation
3. abciximab: anticoagulant preventing restenosis after
angioplasty
4. ABVD: adriamycin, bleomycin, vinblastine, dacarbazine
5. acarbose: inhibits a-galactosidase
6. acebutolol: selective b1 blocker
7. acetaminophen: COX inhibitor which inhibits
prostaglandin synthesis
8. acetaminophen: analgesic, antipyretic (but not
anti-inflammatory)
9. acetaminophen: massive hepatic necrosis
10. acetazolamide: inhibits carbonic anhydrase in the
proximal convoluted tubule
11. acetazolamide: metabolic acidosis
12. acetazolamide: give to alkalinize the urine in aspirin
toxicity
13. acyclovir: used to treat herpes
14. acyclovir: guanosine analog
15. acyclovir: activated by thymidine kinase of the virus it
treats
16. acyclovir: functions as a chain terminator when
incorporated into viral DNA
17. adenosine: short acting agent given IV for AV nodal
arrhythmias
18. adenosine: causes cutaneous flushing
19. albuterol: selective b2 agonist
20. allopurinol: suicide inhibition of xanthine oxidase
21. allopurinol: increases xanthine and hypoxanthine, which
are less likely to form crystals than uric acid
22. allopurinol: slows production of uric acid, used to treat
gout (and cancer)
23. alprazolam: intermediate-acting benzodiazepine used for
panic disorder and phobias
24. alteplase: converts fibrin-bound plasminogen to plasmin
25. aluminum hydroxide: constipating antacid
26. amantadine: prophylaxis against influenza A and rubella
27. amantidine: inhibits fusion of viral particles within
endosome of the cell
28. amantidine: not effective against influenza B
29. amantidine: binds to M2 protein
30. amiloride: block sodium channels in the cortical collecting
tubules
31. amiloride: hyperkalemic metabolic acidosis
32. aminocaproic acid: orally active inhibitor of plasminogen
activation
33. aminocaproic acid: inhibits fibrinolysis
34. aminocaproic acid: used for acute bleeding in hemophilic
patients
35. aminoglutethimide: blocks conversion of cholesterol to
pregnenolone
36. aminoglycosides: bactericidal
37. aminoglycosides: ototoxic and nephrotoxic
38. amiodarone: blocks sodium channels
39. amiodarone: corneal microdeposits
40. amiodarone: class III antiarrythmic
41. amiodarone: photosensitivity
42. amiodarone: pulmonary fibrosis
43. amphetamines: indirect sympathomimetic MOA
44. amphotericin B: disrupts fungal membranes by binding
ergosterol
45. ampicillin: extended spectrum penicillin used to treat
gram negatives
46. anastrazole: aromatase inhibitor
47. anastrozole: inhibitor of steroid synthesis
1
48. anastrozole: inhibits conversion of androstenedione to
estrone
49. antimalarials: erythema multiforme
50. aspirin: PGE inhibitor
51. aspirin: predisposes to acute gastritis by inhibiting PGE in
the stomach
52. aspirin: irreversible inhibitor of cyclooxygenase
53. aspirin: analgesic, antipyretic, antiplatelet,
anti-inflammatory
54. atenolol: selective b1 blocker
55. azithromycin: macrolide
56. aztreonam: b-lactamase resistant monobactam
57. aztreonam: used only with aminoglycosides against gram
negative rods
58. aztreonam: cannot be used against gram positives or
anaerobic bacteria
59. bacitraicin: inhibits bacterial cell wall synthesis
60. barbiturates: erythema multiforme
61. barbiturates: inducer of p450
62. beclomethasone: synthetic glucocorticoid that readily
penetrates the airway mucosa, used for asthma
63. benztropine: antimuscarinic
64. benztropine: CI are prostatic hyperplasia, GI obstruction,
glaucoma
65. benztropine: antimuscarinic used to treat tremors and
rigidity in parkinsons, but does nothing for
bradykinesia
66. bethanechol: muscarinic agonist
67. bismuth subsalicylate: used with metronidazole and
tetracycline for PUD caused by h.pylori
68. bisphosphonates: esophageal ulcerations
69. bleomycin: mixture of glycoproteins that produce free
radicals upon binding DNA
70. bleomycin: causes strand breaks in DNA
71. bleomycin: G2 phase inhibitor
72. bleomycin: can cause pulmonary fibrosis
73. bleomycin: pulmonary fibrosis
74. bromocriptine: D2 agonist
75. bromocriptine: inhibits PRL release
76. bromocriptine: used to treat hyperprolactinemia due to
pituitary adenoma
77. bromocriptine: ergot alkaloid
78. busulfan: pulmonary fibrosis
79. calcium carbonate: hypercalcemic alkalosis
80. calcium carbonate: renal calculi
81. calcium channel blockers: causes cutaneous flushing
82. capsaicin: impairs release of substance P
83. capsaicin: used topically for RA
84. captopril: inhibit breakdown of bradykinin
85. captopril: functions at the collecting tubules
86. captopril: CI in pregnancy
87. carbachol: nicotinic and muscarinic agonist
88. carbamazepine: inducer of p450
89. carbapenem: given with cliastatin
90. carbapenem: used against gram positive cocci, gram
negative rods, and anaerobes
91. carbenicillin: used against enterobacter and pseudomonas
92. carmustine: alkylating agent that causes DNA
cross-linking and strand breaks
93. carmustine: used to treat brain tumors, highly lipophilic
nitrosourea drug
94. carvedilol: used for CHF
95. carvedilol: nonselective beta blocker and alpha-1 blocker
96. cefixime: used to treat gonnorhea
97. ceftriaxone: used for septic meningitis
98. celecoxib: COX-2 inhibitor
99. celecoxib: sulfa drug
100. cephalosporins: bactericidal
101. cephalosporins: causes disulfiram-like reaction
102. chloramphenicol: gray baby syndrome in babies deficient
in hepatic gluconosyltransferase
103. chloramphenicol: aplastic anemia
2
104. chloroquine: primary drug for acute malaria
105. chloroquine: disrupts hemoglobin breakdown, with toxic
accumulation of heme in RBC
106. cholestyramine: bind bile acids to prevent enterohepatic
recycling
107. cimetidine: gynecomastia and galactorrhea
108. cimetidine: p450 inhibitor
109. cimetidine: gynecomastia
110. cinchonism: headache, vertigo, blurry vision, tinnitus
111. cisapride: stimulates peristalsis by release of Ach from
myenteric plexus
112. cisapride: long QT
113. cisplatin: alkylating agent
114. cisplatin: causes nephrotoxicity and acoustic nerve
damage
115. cisplatin: ototoxic and nephrotoxic
116. clarithromycin: macrolide
117. clavulanic acid: beta lactamase inhibitor
118. clindamycin: bacteriostatic at the 50s ribosome
119. clindamycin: treatment of bacteroides
120. clomiphene: blocks negative feedback at the pituitary
121. cocaine: inhibits catecholamine reuptake, resulting in
cardiotox and hypertension
122. colchicine: inhibits microtubule assembly, and therefore
leukocyte migration and phagocytosis
123. colchicine: leukocyte inhibitor used to treat attacks of
gouty arthritis
124. colchicine: microtubule inhibitor
125. cosyntropin: used for diagnosis of addison's disease
126. cromolyn sodium: stabilizes mast cell membrane
127. cyclophosphamide: causes hemorrhagic cystitis
128. cyclophosphamide: alkylating agent used to treat cancers
129. cyclosporin: binds to cyclophilins and inhibits the
transcription of cytokine genes
130. cyclosporin: impairs T cell IL-2 production, used in
transplant patients
131. daclizumab: binds IL-2 receptor on activated T cells
132. daclizumab: used for patients with renal allografts
133. danazol: inhibitor of p450
134. danazol: used for endometriosis and fibrocystic disease of
the breast
135. dantrolene: decreases the release of calcium from the
sarcoplasmic reticulum
136. dantrolene: used to treat malignant hyperthermia
137. daunorubicin: used to treat AML
138. deferoxamine: rapid infusion causes hypotensive shock
139. deferoxamine: used to treat acute iron toxicity
140. DES: clear cell carcinoma of the vagina in daughters
141. desmopressin: selective V2 agonist
142. detromethrophan: depresses cough center in the medulla
143. dicloxacillin: bulky R-group prevents degradation by
penicillinase
144. didanosine (ddI): dose-limiting pancreatitis
145. digibind: fab fragment antibody
146. dimercaprol: chelates metals to keep them from damaging
proteins
147. dimercaprol: used to treat heavy metal poisoning
148. diphenhydramine: inhibit histamine binding to H1
receptors
149. diphenhydramine: causes drowsiness
150. diphenhydramine: used for allergies and motion sickness
151. diphenoxylate: suppress GI motility
152. disulfiram: inhibits aldehyde dehydrogenase, causing an
accumulation of acetaldehyde
3
153. doxorubicin: intercalates in DNA to reduce replication
and transcription
154. doxorubicin: causes dilated cardiomyopathy
155. dynorphins: bind kappa receptors
156. enkephalin: binds delta receptors
157. entacapone: inhibits conversion of levodopa to
3-0-methyldopa
158. ephedrine: ma-huang
159. EPO: recombinant drug used for anemia
160. erythromycin: bacteriostatic inhibitor of 50s
161. erythromycin: macrolide
162. erythromycin: GI irritation and acute cholestatic hepatitis
163. erythromycin: p450 inhibitor
164. etanercept: a fusion product of TNF-alpha receptor and
Fc portion of antibody
165. etanercept: used in RA and inflammatory bowel disease
166. ethambutol: TB
167. ethinyl estradiol/mestranol: lowers risk of coronary
disease, slows osteoporosis, ameliorates hot flashes
168. ethosuxamide: stevens-johnson
169. ethosuxamide: inhbits T-type calcium channels
170. ethylene glycol: causes metabolic acidosis and
precipitation of oxalate crystals in the kidney
171. etoposide: G2 phase inhibitor
172. etoposide: causes double stranded breaks in DNA
173. etoposide: inhibits topoisomerase II
174. etoposide: used to treat small cell carcinoma of the lung
and prostate and testicular cancers
175. fexofenadine: nonsedating antihistaminic
176. filgrastim: G-CSF
177. fluconazole: inhibits formation of ergosterol
178. fluconazole: prophylaxis against cryptococcus neoformans
179. fluconazole: used to treat oral candidiasis
180. fludrocortisone: used in postadrenalectomy therapy
181. flumazenil: antagonizes benzodiazepines and zolpidem
182. flumazenil: used for benzodiazepine overdose
183. flunitrazepam: benzodiazepine used as a date rape drug
184. fluoroquinolones: bactericidal
185. fluoroquinolones: bactericidal inhibitor of DNA gyrase
186. fluoroquinolones: used for gram negative rods, some gram
positives, and neisseria
187. fluoroquinolones: bad for cartilage
188. fluorouracil: S phase antimetabolite
189. fluorouracil: causes myelosuppression
190. fluorouracil: inhibits thymidylate synthase
191. fluorouracil: used to treat colon cancer and basal cell
carcinoma
192. flutamide: used to antagonize residual androgens after
orchiectomy
193. flutamide: side effects include gynecomastia and libido
changes
194. flutamide: androgen receptor antagonist
195. folic acid: will correct anemia but not neuro sx associated
with b12 deficiency
196. foscarnet: treats CMV
197. foscarnet: inhibits viral DNA polymerase
198. gabapentin: partial seizures
199. ganciclovir: guanosine analog converted by CMV to
triphosphorylated form
200. ganciclovir: SE: neutropenia, leukopenia,
thrombocytopenia
201. ganciclovir: metabolized by viral transferases
202. ganciclovir: requires phosphorylation by viral kinases to
work
203. glitazones: increase insulin sensitivity
204. glitazones: stimulate PPAR-gamma receptor
205. gold salts: nephrotoxic
206. gold salts: used in RA
207. gold salts: decreases lysosomal and macrophage function
4
208. griseofulvin: keratinized tissue
209. griseofulvin: ringworm
210. griseofulvin: binds tubulin
211. griseofulvin: inducer of p450
212. griseofulvin: microtubule inhibitor
213. halothane: massive hepatic necrosis
214. HCTZ: hypokalemia, alkalosis, hyperuricemia,
hyperlipidemia
215. heparin: activates AT3
216. heparin: inactivates thrombin
217. HRT: increased risk of breast and ovarian cancer
218. hydantoins: erythema multiforme
219. hydralazine: SLE like syndrome
220. hydroxyurea: used for sickle cell crisis
221. hydroxyurea: increases levels of HbF
222. hydroxyurea: inhbits DNA synthesis by blocking
conversion of ribonucleotides to deoxyribonucleotides
223. ibuprofen: similar to aspirin, lacks antiplatelet effects
224. ibuprofen: reversibly inhibits COX
225. indomethacin: potent NSAID used to close a PDA
226. infliximab: binds and inhibits TNF-alpha
227. interferon alpha: produced by virally infected cells to
prevent infection of adjacent cells
228. interferon alpha: used to treat CML, malignant myeloma,
kaposi sarcoma, hairy cell leukemia
229. interferon alpha: recombinantly produced cytokine
230. ipecac syrup: acts to stimulate chemoreceptor trigger zone
of the medulla
231. ipratropium: dry mouth side effect
232. ipratropium: antimuscarinic for COPD and asthma
233. isocarboxazid: MAOI
234. isoniazid: inhibits synthesis of mycolic acid
235. isoniazid: SE neuritis and hepatitis
236. isoniazid: G6PDH
237. isoniazid: SLE like syndrome
238. ivermectin: onchocera volvulus and strongyloides
stercoralis
239. ivermectin: increases GABA transmission in the worm
240. ketamine: should be given with benzodiazepines
241. ketoconazole: interfere with fungal cell wall synthesis
242. ketoconazole: p450 inhibitor
243. ketoconazole: gynecomastia
244. ketorolac: parenteral NSAID
245. lamivudine: inhibits reverse transcriptase of hepatitis B
246. lamotrigine: stevens-johnson
247. leucovorin: treats myelosuppression
248. leuprolide: treatment for endometriosis
249. leuprolide: treatment for BPH and precocious puberty
250. leuprolide: stimulates release of FSH and LH
251. leuprolide: GnRH agonist used to treat prostate cancer
252. lithium: inhibits IP3 and DAG
253. lithium: causes tremor, hypothyroidism, polydipsia,
polyuria
254. loop diuretics: ototoxic and nephrotoxic
255. loperamide: suppress GI motility
256. loratadine: nonsedating antihistaminic
257. losartan: functions at the collecting tubules
258. losartan: CI in pregnancy
259. lysergic acid diethylamide: hallucinogenic, nausea,
weakness
260. magnesium hydroxide: laxative antacid
261. MAO-B: degrades dopamine
262. MAOI: inhibits breakdown of amine neurotransmitters
263. MAOI + SSRI: serotonin syndrome
264. marijuana: lowers intraocular pressure in glaucoma
5
265. mebendazole: inhibits microtubule synthesis and glucose
uptake by helminths
266. mebendazole: used to treat pinworms
267. mebendazole: microtubule inhibitor
268. mefloquine: used for prophylaxis of p. falciparum due to
low SE
269. meperidine: causes relaxation of the sphincter of oddi
270. meperidine: causes increased ICP
271. mercaptopurine (6-MP): activated by
hypoxanthine-guanine phosphoribosyltransferase
(HGPRT)
272. mercaptopurine (6-MP): inhibits many enzymes involved
in purine metabolism
273. mescaline: hallucinogenic, nausea, weakness
274. metformin: biguanide compound
275. metformin: increases peripheral glycolysis
276. methadone: treatment of opiod withdrawal
277. methanol: causes damage by being converted to
formaldehyde in the liver
278. methanol: retinal damage, blindness, metabolic acidosis,
coma
279. methi, naf, diclox: beta lactams
280. methicillin: bulky R-group prevents degradation by
penicillinase
281. methimazole: same as PTU but crosses placenta and
enters breast milk
282. methotrexate: S phase inhibitor
283. methotrexate: inhibits DHFR
284. methotrexate: folic acid analog
285. methylphenidate: stimulates the release of catecholamines
286. methylsergide: blocks serotonin receptors
287. methylsergide: causes fibroplasia of retroperitoneum and
subendocardium
288. methylsergide: used to prevent migraines
289. metoclopramide: facilitates acetylcholine while blocking
dopamine in the enteric nervous system
290. metoclopramide: SE are sedation, diarrhea,
extrapyramidal symptoms
291. metoclopramide: prokinetic agent used to block emesis
292. metoclopramide: blocks D2 receptors in the area
postrema
293. metoprolol: selective b1 blocker
294. metronidazole: activated by anaerobes and parasites
295. metronidazole: interferes with nucleic acid synthesis
296. metronidazole: used to treat amebiasis, trichomoniasis,
giariasis, and c. diff
297. metronidazole: bactericidal
298. metronidazole: causes disulfiram-like reaction
299. mifepristone: blocks binding of progesterone to
cytoplasmic receptors
300. minoxidil: direct-acting vasodilator
301. minoxidil: used topically bc of benefit of hypertrichosis
302. misoprostol: PGE analog
303. misoprostol: decreases gastric acid production, increases
mucus production
304. misoprostol: eicosanoid preparation used for pts taking
lots of NSAIDs
305. monteleukast: LTD4 and LTE4 antagonist
306. MOPP: mechlorethamine, oncovin, procarbazine,
prednisone
307. morphine: binds mu receptors
308. MPTP: destroys dopaminergic neurons of the nigrostriatal
tract
309. n-acetylcysteine: protects against fulminant hepatic
failure
310. n-acetylcysteine: used for acetaminophen overdose
311. nafcillin: bulky R-group prevents degradation by
penicillinase
312. naloxone: mu opioid receptor antagonist
313. naloxone: used to treat opioid overdose
314. neomycin: used to treat hepatic encephalopathy
315. neomycin: prevents accumulation of nitrogenous
microbial metabolites
6
316. nevirapine: NNRTI used to treat HIV
317. niacin: directly reduces secretion of VLDLs
318. niacin: increases HDL
319. niacin: causes cutaneous flushing
320. nifurtimox: used to treat chagas disease
321. nitrofurantoin: can cause hemolysis in G6PDH deficient
patients
322. nitrofurantoin: can accumulate to toxic levels in patients
with renal failure
323. nitrofurantoin: urinary antiseptic that requires
acidification
324. nitroglycerin: postural hypotension, headache, flushing
325. nitroglycerin: causes increase in cGMP in vascular
smooth muscle
326. nitroprusside: stimulates guanyl cyclase
327. nitroprusside: increases cGMP in vascular smooth muscle
328. nitrous oxide: has a high MAC
329. nystatin: disrupts fungal membrane permeability by
binding to ergosterol
330. nystatin: used to treat oral candidiasis and diaper rash
331. octreotide: used to treat carcinoid, gastrinoma,
somatotropic pituitary adenoma
332. omeprazole: H/K ATPase inhibitor
333. ondansetron: serotonin-3 inhibitor that acts at the area
postrema
334. opiods: causes biliary spasm
335. opioid overdose: constricted pupils, clammy skin, nausea,
drowsiness, resp depression
336. opioid withdrawal syndrome: nausea, chills, sweats,
lacrimation, cramps, rhinorrhea, yawning, piloerection,
diarrhea, tremor
337. organophosphates: anticholinesterases used in chemical
warfare
338. oseltamivir: neuraminidase inhibitor that prevent viral
spreading
339. oseltamivir: used against influenza a
340. paclitaxel: microtubule inhibitor
341. paclitaxel: prevents mitotic spindle breakdown
342. paclitaxel: interferes with anaphase
343. paclitaxel: microtubule stabilizing agent
344. penicillamine: used to treat wilson disease
345. penicillamine: used to treat RA
346. penicillamine: used to treat copper toxicity bc it is a
chelator
347. penicillins: inhibits transpeptidation step in bacterial cell
wall synthesis
348. penicillins: erythema multiforme
349. penicillins: bactericidal
350. PGE: used to maintain a PDA in congenital heart disease
351. phencyclidine (pcp): nystagmus, hypertension, seizure
352. phenelzine: MAOI
353. phenobarbital: binds GABA receptors
354. phenobarbital: increases the duration of chloride channel
opening
355. phenobarbital: used to treat tonic-clonic seizures and
crigler-najjar
356. phenoxybenzamine: adrenergic antagonist (alpha
receptors)
357. phentolamine: used in diagnosing pheochromocytoma
358. phenytoin: inducer of p450
359. phenytoin: SLE like syndrome
360. phenytoin: interferes with folate absorption
361. phenytoin: SE are gingival hyperplasia, hirsutism,
anemia, and birth defects
362. phenytoin: class 1b antiarrhythmic
363. pilocarpine: treatment of glaucoma
364. pilocarpine: muscarinic agonist
365. piperacillin: used against enterobacter and pseudomonas
366. polymyxin b: cationic detergent that disrupts bacterial
membranes
367. polymyxin b: causes neurotoxicity and acute tubular
necrosis
368. polymyxin b: only used topically
7
369. pralidoxime: antidote for anticholinesterases such as
organophosphates
370. praziquantel: used for fluke and tapeworm infections
371. prazosin: first dose syncope
372. prazosin: miosis
373. prednisone: triggers apoptosis
374. prednisone: treatment for leukemia, lymphoma, RA,
asthma
375. primaquine: G6PDH
376. probenecid: competes with uric acid for reabsorption in
the proximal tubule
377. probenecid: inhibits secretion of weak acids
378. probucol: decreases HDL as well as LDL
379. probucol: prevents restenosis after angioplasty
380. probucol: acts as an antioxidant
381. procainamide: SLE like syndrome
382. procarbazine: causes disulfiram-like reaction
383. propylthiouracil: inhibits iodination step of thyroid
hormone synthesis
384. protamine sulfate: reverses effects of heparin
385. psilocybin: hallucinogenic, nausea, weakness
386. pyrantel pamoate: stimulates nicotinic receptors in
nematodes
387. pyrazinamide: TB
388. pyridostigmine: used for tubocurarine toxicity
389. quinine: blocks DNA replication and RNA transcription in
p. falciparum within RBCs
390. quinine: causes cinchonism
391. quinine: used for malaria
392. raloxifene: estrogen partial agonist
393. raloxifene: does not increase the risk of endometrial
cancer
394. repaglinide: rapid onset sulfonylurea
395. repaglinide: binds potassium channels to facilitate insulin
release
396. reserpine: enters the CNS and may cause suicidal
depression and parkinsonian symptoms
397. reserpine: antihypertensive agent that blocks the storage
and release of catecholamines and serotonin from
neurons
398. RhoGAM: antibody to Rh(D) antigen that opsonizes
399. ribavirin: guanosine analog
400. ribavirin: inibits steps in RNA synthesis
401. ribavirin: used to treat viral hemorrhagic fevers and
hepatitis C
402. ribavirin: used to treat RSV
403. rifampin: inhibits DNA-dependent RNA polymerase
404. rifampin: imparts red-orange color to secretions
405. rifampin: TB
406. rifampin: inducer of p450
407. risperidone: causes high sedation
408. risperidone: atypical antipsychotic with lots of
extrapyramidal SE
409. risperidone: blocks D2 and serotonin-2 receptors
410. ritonavir: inhibit protease in the HIV pol gene
411. rituximab: binds CD20 antigen on B cells
412. rituximab: treatment of non-hodgkin lymphoma
413. rofecoxib: COX-2 inhibitor
414. rofecoxib: sulfa drug
415. ropinirole: forestalls the use of levodopa in parkinson's
disease
416. salicylates: erythema multiforme
417. salmeterol: may cause tremors and arrhythmias
418. sargramostim: recombinant GM-CSF
419. scopolamine: competitive cholinergic antagonist used for
motion sickness
420. selegiline: inhibits MAO-B
8
421. selegiline: inhibits degradation of dopamine in CNS, used
with levodopa for parkinson's
422. spironolactone: potassium sparing diuretic
423. spironolactone: aldosterone antagonist
424. spironolactone: functions at the collecting tubule
425. spironolactone: gynecomastia
426. statins: may cause elevated liver enzymes
427. statins: may cause myositis
428. statins: may cause increased CK from skeletal muscle
429. streptogramins: p450 inhibitor
430. streptogramins: arthralgias and myalgias
431. streptogramins: used to treat MRSA and VRE
432. streptokinase: catalyzes conversion of plasminogen to
plasmin
433. streptomycin: TB
434. succimer: orally active metal chelator
435. succinylcholine: muscle relaxant
436. succinylcholine: nicotinic agonist that opens sodium
channels
437. sucralfate: requires acidic environment to polymerize
438. sucralfate: cannot be used with antacids or H2 blockers
439. sulbactam: beta lactamase inhibitor
440. sulfamethoxazole: blocks dihydropteroate synthase
441. sulfinpyrazone: acts simliarly to probenecid
442. sulfonamides: stevens-johnson
443. sulfonamides: G6PDH
444. sulfonamides: photosensitivity
445. sulfonylureas: stimulate closure of potassium channels
446. sulfonylureas: glyburide and glipizide
447. sulfonylureas: cause release of preformed insulin
448. sumatriptan: binds the serotonin 1D receptor
449. sumatriptan: causes vasoconstriction of cerebral
vasculature
450. sumatriptan: used for acute migraine and cluster
headaches
451. tacrolimus: binds to the immunophilin FK-binding protein
452. tacrolimus: used in transplant patients
453. tamoxifen: increases risk of endometrial cancer
454. tamoxifen: estrogen receptor partial antagonist
455. tamoxifen: increases risk of endometrial carcinoma
456. tazobactam: beta lactamase inhibitor
457. tetracycline: inhibits 30s ribosome
458. tetracycline: bacteriostatic drug
459. tetracycline: CI in pregnant women due to bone dysplasia
and dental enamel defects
460. tetracycline: photosensitivity
461. thalidomide: used to treat SLE, multiple myeloma, and
leprosy
462. thalidomide: suppresses production of TNF-alpha
463. thalidomide: potent immunosuppressant
464. theophylline: methylxanthine used for asthma
465. theophylline: inhibits phosphodiesterase
466. theophylline: inhibits conversion of cAMP to AMP
467. thiabendazole: microtubule inhibitor
468. thiopental: ultra-short acting barbiturate used to induce
surgical anesthesia
469. thioridazine: low potency dopamine receptor blocker
470. thioridazine: side effects are retinal deposits, torsades,
postural hypotension, sedation, CNS depression
471. ticarcillin: used against enterobacter and pseudomonas
472. ticlopidine: platelet antiaggregant
473. ticlopidine: interferes with binding of fibrin to Gp2b/3a
receptor on platelets
474. TMP-SMX: blocks folate synthesis
475. TMP-SMX: can cause megaloblastic anemia
9
476. TMP-SMX: do not give to pts with G6PDH deficiency 504. zolpidem: hypnotic drug that is not a benzodiazepine
477. tranylcypromine: MAOI
478. trastuzumab: binds to receptor tyrosine kinase Erb-B2
(HER-2)
479. trastuzumab: used for HER-2 positive breast cancer
480. trimethoprim: blocks DHFR
481. troglitazone: hepatotoxic
482. tubocurarine: nondepolarizing neuromuscular ganglionic
blockers
483. valproic acid: causes neural tube defects
484. valproic acid: used to treat all kinds of seizures, as well as
bipolar disorder
485. valproic acid: massive hepatic necrosis
486. vancomycin: used to treat MRSA
487. vancomycin: used to treat c. difficile
488. vancomycin: rapid IV infusion causes red man syndrome
489. vancomycin: bactericidal
490. vancomycin: causes cutaneous flushing
491. vancomycin: mildly ototoxic and nephrotoxic
492. vasopressin: used to treat esophageal varices
493. vasopression: V1 and V2 agonist
494. vincristine: M phase inhibitor
495. vincristine: blocks microtubule polymerization and spindle
formation
496. vincristine: used for lymphomas, wilms tumor, and
choriocarinomas
497. vincristine: microtubule inhibitor
498. warfarin: interferes with vitamin K dependent clotting
factors
499. zidovudine: inhibits viral reverse transcriptase
500. zidovudine: chain terminator
501. zidovudine: given to prevent transmission of HIV to
neonates
502. zileutin: inhibits leukotriene synthesis
503. zolpidem: binds benzodiazepine receptors, antagonized by
flumazenil

10