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Modified Bier block anesthetic technique is safe for office use for botulinum a

toxin treatment of palmar and plantar hyperhidrosis


DOJ
Contents

Volume 13 Number 3

Modified Bier block anesthetic technique is safe for office use for
botulinum a toxin treatment of palmar and plantar hyperhidrosis
Perry Solomon MD
Dermatology Online Journal 13 (3): 6
Bridges Medical Clinic, San Ramon, CA

Botulinum A toxin (BTX-A) to treat hyperhidrosis (HH) has been shown in


many studies to be efficacious [1-12]. The FDA approved Botox in July
2004 to treat severe underarm HH. The 18-20 injections in this area are
relatively pain free using several 0.3cc 31-gauge B-D short-needle insulin
syringes to maintain the sharpness of the tip. However, more problematic
is how to adequately anesthetize the hands and feet to treat HH in those
areas. Although treating these areas is still an "off-label" use of
Botox , several techniques have been described to numb these regions to
administer the 50 or so injections needed to inject the 100 units of
Botox in each hand or foot. This amount can vary slightly depending upon
the size of the patient.
Some practitioners utilize ice packs, spray with ethyl chloride, use some
type of anesthetic cream such as EMLA, or use nothing at all, and when the
patient feels the inevitable pain of the injections, stops and uses more
of the same [1, 6, 12]. These methods have no place in a modern medical
practice. Proper anesthesia for palmar and plantar injections is mandatory
and, in my opinion, to not do so falls outside the standard of care that
the patient should be given.
Jet injection of either BTX-A or anesthetic medication has been described
[6, 8, 9, 13, 14, 15]. Several drawbacks limit these techniques. Jet
injection of Botox has not been studied to see if the efficacy of the
drug remains intact with the force of the injection through the skin.
Using jet injection to place Lidocaine in the skin to then inject Botox
into the skin weal appears to be a duplication of effort as well not
having been clinically studies for efficacy. Along with the necessity of
purchasing the injector (approximately $5,000) and the need to autoclave
for 30 minutes the metal component and cold sterilizing of the plastic
component adds further costs and time to what should be a simple
procedure. The possibility of nerve injury, lack of efficacy, cost of
equipment and cleaning, inability to properly inject the web spaces and
digits and lack of clinical efficacy makes this method unreliable and not
one that, at least at present, is a viable option.
There is a recent report published describing "vibration anesthesia to use
when performing palmar and plantar injections [16]. The authors themselves
write "the term anesthesia refers to the elimination of pain. . .and the
term analgesia refers to the reduction of pain." They further state that
"although the use of vibration anesthesia generally does not eliminate
pain completely, it can serve to make the injections much more tolerable".
This misnamed article does not really offer a viable technique to provide
adequate and total anesthesia for the painful palmar or plantar
injections.
One adequate anesthetic technique is to use a ulnar, median and radial
nerve block for the hand and a posterior tibial and sural nerve block for
the foot [8, 17, 18]. In experienced hands this type of block is an
excellent way to provide anesthesia. Three major drawbacks exist however.
One is that a successful block is very user dependent and there is a
learning curve to performing it. Another is the potential for nerve injury
that can happen from single attempts at these blocks as well as nerve
injury from repeated injections [19, 20, 21, 22]. Lastly is the onset time

and offset time. Since these procedures are done in an office setting, the
30 minutes or longer that the block needs to take effect and the hour or
longer that it takes to wear off, can mean a 3-4 hour ordeal for the
patient if both hands or both feet are injected, and can leave them unable
to drive themselves home because of continued muscle weakness in those
areas; this type of block gives a full motor as well as sensory block
[23].
A more reliable, safer, easier and more rapid anesthetic block exists. The
Bier block, as first described by Augustus Bier in 1908 [24], has been
used as an excellent technique for Botox administration in a pain-free
environment. However, all reports to date have utilized either the same
methods that have been described for years, whose original application was
for total arm anesthesia, or just using the same volume of anesthetic
compound that has been used in the past and moving the cuff to the forearm
[9, 23, 24, 25, 26, 27], and none have described using it for plantar
injections. Over the past 5 years I have used a modified Bier block
technique in over 150 patients to provide adequate and safe anesthesia in
an office setting so that they have no pain during injections. Due to the
much smaller volume of anesthetic injected, giving the patient a sensory
block and not a major motor block, the patients can be ambulatory with
full use of their hands and feet and drive themselves home within 10-15
minutes after the procedure is completed. The total time for anesthetizing
both hands, injecting the Botox and recovery of function should not take
longer than 1 hour. This modified Bier block technique was first presented
in June 2003 [28].

Technique
A 22-gauge intravenous line is begun in a vein on the dorsum of the hand
(foot) with a Hep-Loc cap placed on the end and secured to the skin with
tape. No solution need be injected into this because of the timing of the
introduction of the anesthetic. A single layer of gauze is placed on the
patients wrist (ankle) with a 12" long tourniquet is wrapped snugly on top
of this and connected to a pneumatic pressure machine.

Figure 1
An Eshmark bandage is then tightly wrapped from the patient's fingers
(toes) to the cuff, with care not to dislodge the intravenous, and the
pneumatic pressure is then turned on to 250-300 torr. The Eshmark is
removed and a finger is placed on the radial artery (posterior tibial) to
check for a pulse and the fingernail (toenail) beds tested for capillary
refill to ensure proper occlusion of arterial blood flow to the hand
(foot). When this is assured, lidocaine (0.5 %, preservative free) is
injected into the intravenous line. The volumes used vary between 12 and
17cc (60-85 mg), depending on the size of the patient's hand (foot). The
patient can experience some warmth in their hand (foot) during the
injection that can be minimized by slow injection and the lidocaine. While
the block is setting up the Botox is reconstituted. Using 2.5cc of
preservative-free saline that is injected into the vial after the top is
removed, the solution is drawn up into five separate 0.5cc 31 gauge B-D
short needle insulin syringes. The top of the vial is removed so that the
thin needle stays sharp to facilitate the injection.

Figure 2
A felt tip pen is used to mark the injection points in the hand. These are
just reference points because, during the injections in the exsanguinated
hand (foot) there are no bleeding marks to see where previous injections
have taken place, it is easy to loose track and miss some areas. The
injections should be made to the side of the pen marks so as not to
"tattoo" the skin. The 50 or so injections are made at a 45-degree angle
into the palm and fingers (sole and toes) in 2-unit aliquots. This should
take about 5 minutes. When finished the tourniquet is released and the
intravenous removed.

Discussion
This is the first published report of the modified Bier block technique
for use in palmar and plantar injections. The criticisms of the classic
Bier block technique used in the past no longer apply using this
modification [23]. The primary concern had been that the sudden release of
anesthetic systemically by a cuff failure or release of the tourniquet in
a short amount of time after injection would cause systemic effects [29,
30]. These reports were made when bupivacaine was utilized for the
anesthetic, which is no longer the standard of care. A review of 20 years
history using the currently recommended anesthetic, preservative-free
lidocaine 0.5 percent, showed that there was a complication rate of 1.6
percent using the standard volume used for full arm anesthesia of 50 cc of
lidocaine 0.5 percent (250 mg), with dizziness, tinnitus and mild
bradycardia being the majority and most severe of them [26]. If we
extrapolate the maximum volume of lidocaine that is used in the modified
technique, 17cc, (85 mg) the possible complication rate would be less then
0.7 percent, none of them serious. In the ulnar, radial and median nerve
block, amounts of lidocaine up to 300 mg have been described. While not
injected systemically in this type of block, the concentration is still
3.5 times what is being described in the modified approach.

Figure 3
There have been comments about bleeding from injection sites resulting in
theoretical toxin washout with the hyperemia that comes after the
tourniquet has been released [23]. With the small 31 gauge needle and the
45 degree injection, which seems to allow the tissue to compress the thin
needle track, there is almost no bleeding from the tiny injection sites.
All the Botox remains at the site of injection and does not leak out.
I do not use the iodine-starch test for the hands and feet. Unlike the
underarms, where it serves to show injections points for hyperhidrotic
areas, in all patients that I have treated, the whole palm and fingers
(plantar foot and toes) have been involved in excessive sweating and
testing these areas would serve no useful purpose in a clinical setting.
Success is measured by patient satisfaction upon follow-up phone calls,
not by an improved starch-iodine test performed a few weeks following the
injections. It also serves no purpose at subsequent visits since the test
would be invalid due to the fact that some areas will not have fully
recovered from the Botox injections.
Regarding the pneumatic tourniquet, in no instance should a standard blood
pressure cuff be used to occlude arterial blood flow because it is
unreliable in holding a steady pressure and will result in an inadequate
block. Although the pressure described can be higher than the 100 torr
more than the patient's systolic pressure that is usually used, for the
short time that the tourniquet is inflated it does not cause patient
discomfort, nor have there been any reported instances of nerve damage for
this short length of inflation and is a good standard pressure. There are
several available types of automated occlusion machines costing
$1,000-$2,000. If a physician plans to perform more then a dozen of this
type of block per year, the cost will be easily recouped and the device
will ensure a proper block.
The most difficult part of the procedure can occasionally be finding a
vein for catheter placement. There are very rare occasions when the HH can
cause patients to have vascular clamp down with venous access difficult.
In these infrequent cases an ulnar, median and radial nerve block can be
performed.
The fact that the modified Bier block technique is very safe, easy to
learn and administer and allows full recovery within a very short time,
makes it the anesthetic technique of choice in the office setting for
providing a pain-free injection field for Botox injections in the hands
and feet to treat hyperhidrosis.
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