GENERIC NAME: Glicazide BRAND NAME: Diamicron GENERAL ACTION: Oral Antidiabetic Agent

ACTION: Pharmacology: Gliclazide is a sulfonylurea which stimulates insulin secretion by the pancreas. Its action on insulin secretion is mainly due to the restoration of the early phase, resulting in a physiological release of insulin. Thus, gliclazide restores glycaemic control throughout 24 hrs. It normalizes fasting and postprandial blood sugar.

In man, apart from having hypoglycemic effect, gliclazide has been shown to reduce platelet hyperadhesiveness and hyper-aggregation and to increase fibrinolytic activity. Moreover, it has been demonstrated that gliclazide possesses specific antioxidant properties. As such, gliclazide scavenges free radicals, and therefore, decreases the oxidative stress, to which the diabetic patient is commonly exposed.

INDICATIONS: Non-insulin-dependent diabetes (type 2)

CONTRAINDICATIONS: Contraindicated in: Type 1 diabetes; diabetes complicated with ketosis and acidosis; pregnancy; diabetes under going surgery; hypersensitivity to sulfonylureas and related drugs; diabetic precoma; severe liver or kidney disease; treatment with miconazole. Use cautiously in: Hepatic or renal impairment; hypoglycemia may occur with too high doses or reduced dietary intake.

ROUTE AND DOSAGE: Oral Total daily dose may vary from 1-4 orally. Adjust dose according to patient’s individual response in the majority of cases, 2 tabs/day with meals. Elderly diabetic: starting dose is ½ tab in the morning and ½ tab in the evening.

Use in pregnancy: If the patient is pregnant. Gastrointestinal Disorders: Nausea. swallow whole and do not chew or crush.ADVERSE REACTIONS: • • • Hypoglycemic manifestations (sweating. stomach upsets. Regularly carry out the laboratory tests as prescribed or recommended by the doctor. itching. corticoids. visual disturbances. β-blockers. pallor. Instruct the patient that it should be taken with meals. malaise). • • Do not take a double dose to compensate for the single dose that was not taken. • Abnormal laboratory results affecting blood and liver functions. NURSING RESPONSIBILITIES: • • Always check the patient’s blood sugar regularly. Skin Reactions: Urticaria. difficulty in eating. in particular. planned pregnancy. intense hunger. immediately eat sugar or something containing sugar and inform the doctor. administration of other drugs. constipation. fever or infection. anti-inflammatory agents. there is a risk of an imbalance in diabetes (hyperglycemia). If the treatment is discontinued. strictly comply with the doctor's prescription. feeling of malaise. • Inform the doctor in the following cases: Surgery. diabetes should be treated with insulin. trembling. • • Avoid alcohol and alcoholic drinks. In all cases. • • Advise the patient that the drugs is best taken at breakfast. hepatitis. abnormal behavior. trauma. intense hunger. • In the case of sweating. diarrhea. pallor. . skin rash.

diuretics. If the patient is pregnant. miconazole or alcohol. inform the doctor or pharmacist. especially danazol (hormonal drug). inform the doctor so that he may prescribe a more suitable treatment. The patient must not take other drugs on his own initiative.• Inform the doctor if the patient wishes to become pregnant. • Certain interactions with other drugs must be avoided as they can cause significant changes in the blood glucose levels. If the patient is unconscious. immediately inform the doctor and call the emergency services. • The administration of an excessive dose results in hypoglycemia which should be treated immediately by the administration of sugar. . • The doctor or pharmacist must be informed if the patient is taking or have recently taken any other drugs. corticoids. • If any undesirable effects which have not been mentioned occur.

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