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TRICHOPHYTON RUBRUM

1. TAKSONOMI
- Domain : eukaryota
- Kingdom : Fungi
- Phylum : Ascomycota
- Class : Eurotiomycetes
- Order : Onygenales
- Family : Arthrodermactaceae
- Genus : Trichophyton
- Species : T.rubrum
- Synonim : T.fischeri, T.raubtschekii, T.kaneii

2. DESKRIPSI
- Penyebab dermatophytosis tersering
- Anthropophilic fungus
- Keratinophilic filamentous fungus

3. GENOME STRUCTURE
- Diketahui 5 kromosom

4. VARIANT
- Lokasi
o Africa&southern asia : Tinea corporis dan tinea capitis
o Global : tinea pedis, tinea cruris
- Kromosom
o T.megninii : portugal
o T.soudanese & T.gourvilli : subsahara africa
o T.raubitschekii : india, southeast asia, west Africa

5. COLONY STRUCTURE
- Typical : white-cream color pigemwnt with reverse side color (yellow-brown-red wine)
- Tekstur : flat and slightly raised

6. CELL STRUCTURE
- Repro : aseksual with conidiospora (mikro dan makro)
- Hyphae : thin walled septae w/bacillus shaped/cigar shaped
7. METABOLISM
- Memiliki protease (keratinase) ingesti keratin untuk pertumbuhan
- Optimal pada pH asam

8. ECOLOGY
- Anthrophilic dermatophyte : hidup di tempat lembab atau tinggi keratin di kulit manusia
- Bisa bertahan di bedding ataupun clothing

9. PATHOLOGY

adhesi @ sekresi proteolitic


invasi keratin
st.corneum enzim

dermatoohytosis
growth >> degradasi kertain
infection

10. CONFIRMATORY TEST


- Kultur : SDA, Littman oksgali agar
- Urea test : -/+
- Microscopic test with KOH

MALASSEZIA FURFUR

1. TAKSONOMI
- Domain : eukaryota
- Kingdom : Fungi
- Division : Basidiomycota
- Subdivision : ustiaginomycotina
- Class : eksobasidiomycetes
- Order : Malasseziales
- Family : Malasseziacea
- Genus : Malasseziacea
- Species : M.furfur
- Synonim : pitysporum

2. DESKRIPSI
- 1.5-4.5m x 2-6 m
- Spherical (coccal)
- Bottle neck at one end
- Normal flora at human single cell individual (yeast)
- Pathogenic form filament form (spore)
- Lipophilic yeast butuh lemak dan minyak (35oC)
- Culture : cream-white color
3. STRUKTUR AND METABOLISM
- Coccal, (+) plasma membrane dengan laminar cell wall yang tebal (berisi chitin)
- Bottle neck shaped
- Butuh asam lemak dan sumber karbon
- Memproduksi
a. Tryptophan aminotransferase
L-triptophan indole pyruvat
b. B-glucosidase
Memecah selulosa glukosa
- Hyphae, induksi:
a. Cytokines induksi inflamasi
b. CHemokines direct cll movement
c. Adhesi molecule stick to epitel

4. PATOGENESIS
hidup normal di
kulit

konsumsi natural
oil and fat (sebum
dan keringat) >>

populasi M.furfur
melebihi normal

Dermatitis
Piyriasis vesicolor
seborroik

indole indirubin & indolo


melassazin pityriacirin AhR ligand Piyriarubins
(pityriarubins) carbazole

prevent
impede regulasi apoptosis interaksi dengan mediator
maturation UV absorbent
neutrophils melanosit EGFR inflamasi
dendritic cells

skin lesion large


mediator protect fungus
Hipopigemnetasi plak, oily, rash itching
inflamasi from UV radiation
dandruff, hairloss

R.inflamasi

5. DIAGNOSIS