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Ursodeoxycholic acid (INN, BAN and AAN), also In newborn infants with impaired bile ow[7]
known as ursodiol (USAN) and the abbreviation UDCA,
from the root-word for bear urso, as bear bile contains the
substance, is one of the secondary bile acids, which are
metabolic byproducts of intestinal bacteria.
1
2 6 REFERENCES
Hyodeoxycholic acidan isomer [13] Kotb MA (July 2008). Review of historical co-
hort: ursodeoxycholic acid in extrahepatic biliary atre-
sia. Journal of Pediatric Surgery. 43 (7): 13217.
doi:10.1016/j.jpedsurg.2007.11.043. PMID 18639689.
6 References
[14] Paediatric Formulary Committee (2008). British National
[1] Akare S, Jean-Louis S, Chen W, Wood DJ, Powell AA, Formulary for Children 2008. London: Pharmaceutical
Martinez JD (December 2006). Ursodeoxycholic acid Press. p. 91. ISBN 0-85369-780-9.
modulates histone acetylation and induces dierentia- [15] Urso package insert. Birmingham, AL: Axcan Pharma
tion and senescence. International Journal of Cancer. U.S.; 2000 Jan.http://www.axcan.com/pdf/urso_patient_
Journal International Du Cancer. 119 (12): 295869. brochure.pdf
doi:10.1002/ijc.22231. PMID 17019713.
[16] Cheng K, Ashby D, Smyth RL (Dec 2014). Ur-
[2] Amaral JD, Viana RJ, Ramalho RM, Steer CJ, Rodrigues sodeoxycholic acid for cystic brosis-related liver
CM (September 2009). Bile acids: regulation of apop- disease. Cochrane Database Syst Rev. 12: CD000222.
tosis by ursodeoxycholic acid. Journal of Lipid Re- doi:10.1002/14651858.CD000222.pub3. PMID
search. 50 (9): 172134. doi:10.1194/jlr.R900011- 25501301.
JLR200. PMC 2724780 . PMID 19417220.
[17] Lindor KD, Kowdley KV, Luketic VA, et al. (Septem-
[3] Material Safety Data Sheet on Ursodiol MSDS. https:// ber 2009). High-dose ursodeoxycholic acid for the treat-
fscimage.fishersci.com/msds/70916.htm ment of primary sclerosing cholangitis. Hepatology. 50
(3): 80814. doi:10.1002/hep.23082. PMC 2758780 .
[4] https://www.uptodate.com/contents/
PMID 19585548.
ursodeoxycholic-acid-ursodiol-drug-information?
source=preview&search=ursodeoxycholic%20acid& [18] http://www.who.int/medicines/publications/
anchor=F232620#F232620 druginformation/issues/26-1.pdf
[5] https://www.uptodate.com/contents/ [19] Public Assessment Report for paediatric stud-
ursodeoxycholic-acid-ursodiol-drug-information? ies submitted in accordance with Article 45
source=preview&search=ursodeoxycholic%20acid& of Regulation (EC) No1901/2006, as amended
anchor=F232620#F232620 http://www.google.com.eg/search?q=public+MAH+
UDCA&hl=en-EG&gbv=2&oq=&gs_l=
[6] https://www.uptodate.com/contents/
cystic-fibrosis-hepatobiliary-disease?source=search_ [20] PUBLIC ASSESSMENT REPORT of the Medicines
result&search=cystic%20fibrosis&selectedTitle= Evaluation Board in the Netherlands http://mri.
2~{}150#H106943356 medagencies.org/download/NL_H_2516_001_PAR.pdf
3
7 External links
Ursodeoxycholic acid information at MedlinePlus
8.2 Images
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