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Informet ®

Tablet
(Metformin Hydrochloride)

Description decision to use this drug should be balanced against the benefits and
Informet® (Metformin Hydrochloride) belongs to a biguanide class of risks.
oral antidiabetic drugs. It decreases hepatic glucose production, Nursing Mothers : It is not known whether Metformin Hydrochloride is
decreases intestinal absorption of glucose and improves insulin secreted in human milk.
sensitivity. Unlike sulfonylureas, Metformin does not produce Paediatric & Geriatric use : Safety and effectiveness in paediatric
hypoglycemia. It is the drug of first choice in obese patients. patients have not been established. Dosage adjustment should be
based on a careful assessment of renal function in elderly patients.
Indications
Metformin Hydrochloride, as monotherapy, is indicated as an adjunct Drug Interactions
to diet to lower blood glucose in patients with non-insulin-dependent Nifedipine : Nifedipine appears to enhance the absorption of
diabetes mellitus (NIDDM) whose hyperglycemia cannot be Metformin. Metformin has minimal effects on nifedipine.
satisfactorily managed on diet alone. Metformin Hydrochloride may Other : Certain drugs tend to produce hyperglycemia and may lead to
use concomitantly with a sulfonylurea when diet and metformin loss of glycemic control. These drugs include thiazide and other
hydrochloride or sulfonylureas alone do not result in adequate diuretics, corticosteroids, phenothiazines, thyroid products, estrogens,
glycemic control. oral contraceptives, phenytoin, nicotinic acid, sympathomimetics,
calcium channel blocking drugs, and isoniazid. When such drugs are
Dosage and Administration administered to a patient receiving Metformin HCl, the patient should
Informet ® 500 : Initial dosage is 500 mg tablet 2-3 times daily with or be closely observed to maintain adequate glycemic control.
after meals, gradually increased if necessary to 2 to 3 g daily.
Informet ® 850 : Initial dosage is 850 mg tablet once or twice daily with Overdosage
or after meals, gradually increased if necessary to 2 to 3 g daily. Hypoglycemia has not been seen even with ingestion of up to 85
Informet ® LA : The usual starting dose of Informet LA (Metformin grams of Metformin HCl, although lactic acidosis has occurred in such
Hydrochloride long acting) is 500 mg once daily with the evening meal. circumstances. Hemodialysis may be useful for removal of
Dosage increases should be made in increments of 500 mg weekly, up accumulated drug from patients in whom Metformin overdosage is
to a maximum of 2000 mg once daily with the evening meal. If suspected.
glycemic control is not achieved on Informet LA2000 mg once daily, a
trial of Informet LA1000 mg twice daily should be considered. Pharmaceutical Precaution
0 0
Store at 15 -25 C. Keep in a cool & dry place. Keep out of the reach of
Transfer from Other Antidiabetic Therapy: When transferring patients children.
from standard oral hypoglycemic agents other than Chlorpropamide to
Metformin HCl, no transition period generally is necessary. When Commercial Pack
transferring patients from Chlorpropamide, care should be exercised Informet ® 500 : Box containing 100 tablets in 10x10’s blister strips.
during the first two weeks because of the prolonged retention of Each tablet contains Metformin Hydrochloride BP500 mg.
Chlorpropamide in the body, leading to overlapping drug effects and Informet ® LA : Box containing 100 tablets in 10x10’s blister strips.
possible hypoglycemia. Each long acting tablet contains Metformin Hydrochloride BP500 mg.
Informet ® 850 : Box containing 60 tablets in 6x10’s blister strips. Each
Side Effects tablet contains Metformin Hydrochloride BP850 mg.
Diarrhoea, nausea, vomiting, abdominal bloating, flatulence, and
anorexia are the most common reactions to Metformin Hydrochloride.
Lactic acidosis also rarely occurs.

Contraindications
Metformin Hydrochloride is contraindicated in patients with renal
disease or renal dysfunction, congestive heart failure, known
hypersensitivity, acute or chronic metabolic acidosis, including diabetic
ketoacidosis, with or without coma.

Precautions
Metformin Hydrochloride therapy should be temporarily suspended for
any surgical procedure (except minor procedures not associated with
restricted intake of food and fluids) and should not be restarted until
the patient's oral intake has resumed and renal function has been
evaluated as normal. It should be used with caution in case of
excessive alcohol intake and hepatic insufficiency. It should be
temporarily discontinued in patients undergoing radiologic studies
involving intravascular administration of iodinated contrast materials, BEXIMCO
PHARMA
because use of such products may result in acute alteration of renal Manufactured by
function. BEXIMCO PHARMACEUTICALS LTD.
Use in Pregnancy & Lactation TONGI, BANGLADESH
Pregnancy : Safety in pregnant women has not been established. Any ® REGISTERED TRADEMARK