You are on page 1of 29

General Curriculum

Cell injury and Adaptation


Part I

ZHOU REN

Prof., M.D., Ph.D.

Institute of Pathology & Forensic Medicine


Department of Pathology & Patho-physiology
Zhenjiang University Judicial Evidence & Evaluation Center

Zhejiang University School of Medicine


Course of Basic Medical Sciences Chapter 1

Chapter 1. Cell injury and Adaptation


Part I
Course of Basic Medical Sciences Chapter 1
Course of Basic Medical Sciences Chapter 1

(1). Adaptation

Def. Cells may alter their


metabolism, function or even
structure to escape injury caused
by their environmental changes.
The process of alteration is called
as adaptation
Course of Basic Medical Sciences Chapter 1

z Atrophy
z Hypertrophy
z Hyperplasia
z Metaplasia
Course of Basic Medical Sciences Chapter 1

(1)Atrophy:

Def. Acquired shrinkage in size of an organ


caused by decrease in size of its constituent
cells.
Course of Basic Medical Sciences Chapter 1

Poor nutrition
Course of Basic Medical Sciences Chapter 1
Course of Basic Medical Sciences Chapter 1

loss of blood supply


Course of Basic Medical Sciences Chapter 1

z Atrophy of brain
Course of Basic Medical Sciences Chapter 1
Course of Basic Medical Sciences Chapter 1

Compressed atrophy
Course of Basic Medical Sciences Chapter 1

Disuse atrophy

Decrease of endocrine stimulation


Course of Basic Medical Sciences Chapter 1

Neurogenic atrophy
Course of Basic Medical Sciences Chapter 1

(2)Hypertrophy:

Hypertrophy refers to an increase in the


size of an organ or tissue by increase in
the size of the constituent cells.
Course of Basic Medical Sciences Chapter 1
Course of Basic Medical Sciences Chapter 1
Course of Basic Medical Sciences Chapter 1
Course of Basic Medical Sciences Chapter 1
Course of Basic Medical Sciences Chapter 1

(3)Hyperplasia:

Hyperplasia refers to an increase in the


number of cells in an organ or tissue.
Course of Basic Medical Sciences Chapter 1

(4)Metaplasia:

Metaplasia is a reversible change in which


one adult cell type is replaced by another adult
cell type.

Squamous metaplasia of bronchia epithelium.


Course of Basic Medical Sciences Chapter 1
Course of Basic Medical Sciences Chapter 1
Course of Basic Medical Sciences Chapter 1

Intestinal metaplasia of gastric mucosa


Course of Basic Medical Sciences Chapter 1
Course of Basic Medical Sciences Chapter 1

Intestinal metaplasia of gastric mucosa


Course of Basic Medical Sciences Chapter 1
Course of Basic Medical Sciences Chapter 1

Key words in this chapter


z Atrophy
Poor nutrition
loss of blood supply
Compressed atrophy
Disuse atrophy
Decrease of endocrine stimulation
Neurogenic atrophy
z Hypertrophy
z Hyperplasia
z Metaplasia