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In vitro In vivo
It is very fast, which is valuable especially It would take days or weeks to produce the
when only a small amount of DNA is available same quantity of DNA as in vitro.
e.g. at the scene of a crime.
It does not require living cells meaning that It involves culturing the bacteria or vector
complex culturing techniques are not needed. which is often a complex and long procedure
It involved no risk of contamination as the
It requires a very pure sample as any restriction endonuclease can match the
contaminant DNA would also be multiplied sticky ends together
At any one time, 20% of the DNA cloned is It is very accurate as the DNA copied has very
copied inaccurately although modern few, if any, errors.
techniques have now improved.