TopicNo

SECTION-I

Hrs.

1.

Concept of Formulation Design: a) Preformulation: Introduction, General consideration, Preliminary evaluation & molecular optimization, Bulk characteristics, Solubility analysis, Stability analysis. b) Design of Dosage Form: Principles, Dosage form design, Biopharmaceutical & Therapeutic aspects of dosage form design. c) Study of excipients: Introduction, classification & selection criteria Stability studies:Concept of stability studies. a) cGMP & ICH guidelines for Accelerated stability Testing. b) Interaction of containers & closure Compatibility Testing

5

2.

5

3.

III. Solid Dosage Forms: A. Tablets: Introduction, Advantages & Disadvantages, Types of tablets. Formulation development: Preformulation of drugs & additives. Introduction to tablet additives. Need of granulation. Mechanisms, Manufacturing processes and Equipments for Wet granulation and Dry granulation processes. Advanced granulation techniques ± Extrusion, spheronization, Pelletization, Spherical crystallization, Fluidized bed granulation, Melt solidification & granulation. Characterization and Evaluation of granules. Mechanism, Manufacturing process and Equipments for Direct compression technique. Physics of Tablet compression. Tablet compression machines. Formulation and manufacture of Chewable tablets, Effervescent tablets, Dispersible tablets, Mouth dissolving tablets, Layered & Compression coated tablets. Manufacturing problems & remedies thereof. Packaging & labelingstrip, blister & bulk packaging. IPQC for tablets. Evaluation of tablets as per

20

IP, BP, USP

Tablet Coating: Introduction and concept of tablet coating. Types of tablet coating including Sugar, Film & Enteric coating. Material, processes employed & equipments for tablet coating. Manufacturing problems & remedies during tablet coating. Evaluation of coated tablets. Layout of tablet manufacturing section. B. Capsules:a) Raw material for capsule shell: Manufacturing of gelatin for capsule. Introduction and concept of size selection of capsules. Selection criteria

4

1 10

54 and size selection of capsules (with examples) b) Hard gelatin capsules: Preparation of hard gelatin capsule shell, standards & defects thereof. Formulation & development: Filling, processing & capsule filling equipments. Problems in capsule filling & remedies thereof. In process quality control & quality control parameters. Soft gelatin capsules: formulation and development, manufacturing, processing & equipment. In process quality control & quality control parameters. Packaging & labeling of capsules: Strip, Blister & Bulk Packaging. SECTION- II

1.

Disperse systems:Free energy consideration, thermodynamic v/s kinetic stability. Classification of disperse system. A) Suspensions: Physicochemical principles. Theory of suspension: DLVO theory. Wetting, Sedimentation, Flocculated & Deflocculated system. Structured vehicle, particle size, particle charges & caking in suspensions. Importance of changes in solubility because of changes in particle size, polymorphic form, temp. Preformulation data. Formulation development, manufacturing, packaging & equipments employed for the same. Rheology of suspensions. Formulations of pharmaceutical suspensions (oral & topical), suspending agents, wetting agents, dispersants, deflocculating & flocculating agents. Evaluation of suspensions. Quality control standards. B) Emulsions: Physicochemical principles. Theory of emulsification. Creaming, coalescence, cracking, destabilization kinetics, role of viscosity, energy barriers to coalescence. Film barriers, steric stabilization. Emulsifier & choice of emulsifier, HLB value & phase inversion temperature. Multiple emulsions. Evaluation of emulsion, stress testing. Packaging of emulsions. C) Suspension & emulsion manufacturing equipments: Mechanical stirrers, homogenizers, colloid mill, foaming removal.

2

10

6

2

D) Layout and designing of manufacturing facility for suspension and

1

cold. paste and gels.Retinoids. depilatories. antiperspirants. Lacquer remover. 8 3. cleaning. Processing equipments for ointment. Formulation. Manicure products: Nail lacquer.& sunscreen preparations. Hair products: Shampoos. face pack. eye liner. paste and gels. manufacturing & safety testing & quality control of following cosmetics. hair dyes.emulsion. skin irritation test. In process quality control & quality control parameters. 55 2. Formulation and development. semisolid bases and additives. cream. suntan. Lip product: Lipstick. Definition and difference from cosmetics. beta 4 . III ) Cosmetics & Cosmeceuticals: A) Cosmetics: Cosmetics v/s drug formulation. shaving preparations. deodorants. anti wrinkle. Paste and Gels. Percutaneous absorption. Eye products: Eye mascara. eyebrow pencil. eye shadow. Cream. manufacturing of Ointment. History of cosmeceuticals. Selection of bases and additives for ointment. Cosmeceutical Agents. vanishing. cream. packaging & labeling. hair tonics. hydroxyl acids. 12 B) Cosmeceuticals: Introduction. Semisolids: Properties of drugs. Type of cosmetics. Skin products: Moisturising.

(3 hrs/week) I) Raw material testing of any 5 Experiments II) Formulation. Viscosity. 3. Stability.hydroxyl acids. Organoleptic Properties. y y o 1. Antioxidants and others. and assay of any one preparation y y o 2. Suspensions ‡ Calamine lotion y o ‡ Milk of Magnesia y o ‡ Paracetamol Suspension y o ‡ Antacid Suspension Evaluation Parameters: Sedimentation volume. Preparation and Evaluation of the following dosage forms. Recent developments in Cosmeceuticals. Emulsions ‡ Liquid paraffin oral Emulsion y . pH.1 PHARMACEUTICS-II (Practical) 90 Hrs.

Semisolids ‡ Pain balm 56 y o ‡ Antifungal ointment/cream y o ‡ Medicated Gel y o ‡ Antiacne preparation ‡ Non staining Iodine ointment with Methyl Salicylate Evaluation Parameters: pH. Globule size. Organoleptic properties and assay of any one preparation y y o 4. wt/ml. pH. Tablets ‡ Aspirin ± Using non aqueous binder solution y . Spreadability. and assay of any one preparation y y o 3.o ‡ Turpentine Liniment y o ‡ Formulation of Emulsion (HLB Consideration) Evaluation Parameters: Organoleptic Properties.

Angle of repose. Tablet Coating (Demonstration) 7. Dimensions. Dispersible. Tablet porosity. Cosmetics ‡ Cold cream y o ‡ Vanishing cream y . Dissolution time. Particle size. Disintegration time. Friability. Capsules ‡ Ferrous Fumerate Capsules y o ‡ Antibiotic Capsules Evaluation of Empty and Filled Hard gelatin capsule shell. Densities and Carr¶s Index Evaluation of Tablets: Hardness. y y o 5. Effervescent Tablets y y Evaluation of granules.Weight variation. dissolution time y y y o 6. Evaluation of capsule.o ‡ Paracetamol ± By Wet granulation y o ‡ Chewable. Weight variation. Assay and Uniformity of content of any one preparation.

Foam test for shampoo and shaving cream y Film formation test for lipstick and eye preparation. Recommended Books . Eye liner. Eye Mascara y o ‡ After shave lotion y o ‡ Nail lacquer Evaluation Parameters: Organoleptic properties for all preparation.o ‡ Shampoo y o ‡ Tooth Paste y o ‡ Saving cream y o ‡ Moisturising cream y o ‡ Sunscreen cream/lotion y o ‡ Lip stick y o ‡ Eye shadow.

5.Kanig ³The Theory and Practice of Industrial Pharmacy´ 3rd edition.Swarbrick.Allen ³Pharmaceutical dosage forms and Drug Delivery systems´ 9th edition. 1987.Chalmers ³Pharmaceutics and Pharmacy Practice ³J.B. 1998. I.E.B. N. 1996.A. Chichester. 2009. PA. III 1998. / Special Indian edition.Liberman.Lieberman.ich. 6. Vol. H. J.Poporich. L.Lachman and J. 8. K. 2007. 57 2. James J.G. L. Verghese publishing House. 2009.C. J. London. G.Lippincott Company.Boylan´ Encyclopedia of pharmaceutical technology´ Vol.org 4. Mack publishing company.Schwart ³Pharmaceutical dosage forms: Tablets´ Marcel Dekker. Churchil livingstone. Mumbai 1991. J.C. Marcel Dekker. ELBS Publication. UK. 9. www. Remington ³The science and practice of pharmacy´ 21st edition.1.A.Ridgway ³Hard Capsules Development and Technology´ The Pharmaceutical Press.Wells ³ Pharmaceutical Preformulation : The physicochemical properties of drug substances ³ Ellis Horwood. Philadelphia.Aulton ³Pharmaceutics ±The design and nanufacture of medicines´ 3rd edition. 8th edition. H. .1. 2005. Wolters kluwer/ Lippincott Williams and wilkins. 10. 1982.K. 7.Lachman. M. II. UK.S. R. H. Bentley¶s ³Test book of Pharmaceutics´ Bailliere Tindall.V.banker.L. L. 11.1988 3.Ansel.

III. Government of India. Stationary office on behalf of .Wilkinson and R. R. Indian Pharmacopoeia Commision. I. 1994 19. 17. Vol. I. W. ³Indian Pharmacopoeia´ 2007. II. 2001. II. I.Moore ³Harry¶s Cosmetology´ 7th edition.Thosmssen´ Modern cosmetics Universal Publishing Corporation. Augsberger. Lieberman.A. Longman Scientific and Technical. J. ³USP 30 NF 25 The United States Pharmacopoeia´ 2007.Knowlton and S. Riser and Banker ³Pharmaceutical Dosage forms and Disperse system´ Marcel Dekker. III.B. 13. P.12. L. J. I. III. II. Ministry of Health and Family Welfare. J.Appell ³The formulation and preparation of cosmetics. 14. 23. W. 22. S. Longman science and technical. Manufacturing and Quality Control´ 7th edition. III. UK. Cosmetics and Soaps´ Vol. ³Harry¶s Cosmetology´. Wilkinson. 16.Pocher´ Poucher¶s Perfumes. II. Hoag ³Pharmaceutical Dosage Forms: Tablets´ 3rd edition. B. Chapman and Hall 21. 1993 15. Sharma. III 2008. I. Vol.Rearce ³ Handbook of cosmetic science and technology´ 1st edition. II. National formulary publication of US Pharmacopoeia. Vandana publication. 7th edition. E. Moore. L. Informa Healthcare. fragrance and flavours´ Micelle press 20. 18. Dr. J. 24. L. III 1988. IV. ³Cosmetic Formulation. ³British Pharmacopoeia´ 2005.G. Elsevier science publisher. Laba ³Rheological properties of cosmetics and toiletries´ Marcel Dekker. oxford. P. Vol.J. Vol. Vol. London 1982.

polymerase. Genetic Engineering : 2.Introduction. 4 Gene transfer: ± Introduction & Types (Direct & Indirect gene transfer methods) Ti & Ri plasmid mediated gene transfer. ligase. Restriction Fragment Length Polymorphism (RFLP). Blotting techniques. DNA fingerprinting. DNA Hybridization. Introduction to Biotechnology. Gel electrophoresis. alkaline phosphatase.1 Recombinant DNA technology :Gene cloning :.2 Genetic Engineering techniques :Isolation of DNA.Medicine and Healthcare Product Regulatory Agency (MHRA). (2 hrs per week) TopicNo SECTION-I Hrs. Genomic & cDNA libraries. reverse transcriptase). Scope. types of cloning vectors. transformation & growth of cells. enzymes acting on DNA (restriction endonucleases. Selection of clones ( screening methods). Human Gene therapy. Gene synthesis & gene machine.2 PHARMACEUTICAL BIOTECHNOLOGY (Theory) 60 Hrs. expression vectors (expression vectors in brief). S1 nuclease. Gene sequencing methods. polymerase chain reaction (PCR) Site directed mutagenesis. 1. 58 3. Potential & Achievements 1 2. 2. 4 8 .

methodology & applications of above types) 3.2 Hybridoma technology. media & laboratory requirements for tissue culture 3. Preparation of chicken serum. Application) 3.1 Introduction. meristem.2 Types of cultures:. 4. mammalian serum & embryo extract. haploid cultures.3 Protoplast culture & protoplast fusion & application Transgenic Plants introduction.3.1 Introduction to plant cell.2 Introduction to transgenic animals and their applications 5 SECTION. preparing cells in culture. Subculture and recombinant vaccines. Plant Cell and Tissue Culture:3.II 5. suspension. Edible vaccines 5. Animal Cell Culture 4. Preparation of Monoclonal Antibodies and its 7 59 . Role of blood plasma & serum. hairy root.4 Germplasm storage & cryopreservation 8 4.1 Vaccines Why vaccines? How it works? Traditional vaccine approaches. Method. Future directions. established cell lines. Immunotechnology 5. culture media for animals. anther cultures /Pollen grains (Introduction.Callus. isolation of cells. root-tip.

Immunofluoroscence 6. Immobilization of enzyme & its applications 2 7. Biogenetic drugs (Production and uses) 8. 8. Fermentation discharge and Effluent treatment 7. Streptomycin. its material of construction. Accessory components and working. and storage of blood and blood 6 .2 Purification Toxicity studies in establishing safety and efficacy in biotechnological Products. processing. Tetracycline). Down streaming Processing (Product Recovery and Processing). Fermentation Technology 7. Radio Immuno Assay (RIA). Healthcare Biotechnology:8.3 General Application of fermentation in Manufacturing of Antibiotics (penicillin.1 Study of methods at sterilization details & their applications to Pharmaceutical Manufacturing 7.1 Examples of Biotechnology derived Products: Human insulin. 2 Fermentation as a biochemical process ± Fermenter. Somatotropin.applications 5. Interferons.3 Introduction to collection.Enzyme Linked Immuno Sorbant Assay (ELISA). Enzyme Technology Introduction to enzyme. Vitamins (Vitamin B2 and Vitamin B12) 10 8. Dextran.3 Immunoassay by different techniques.

9. Vyas and Dixit Pharmaceutical Biotechnology.2 Humans:-Artificial Insemination (Al). Rastogi Publication. 1st CBS Publisher New Delhi. Genetics 5th Edition . Watson WH Freeman and company N. Elements Of Biotechnology.S. Pharmaceutical Biotechnology: Drug Discovery and Clinical Application. Freezing germ cells.Y. Wiley VCH publisher.1 Social & ethical issue in Pharmacy. Iganacimuthu. USA 2003 60 5. S. Peter J. Human Embryos and Cloning (Facing Problems and finding solutions) 5 Total Recommended Books: 1. 2004 60 2. 1991 6. Dr. In-vitro Fertilization & embryo Transplants.products 9. Gliek. Biotechnology and Ethics :9. Recombinant DNA 2nd edition Holtzbrinck Publishers 1992 4. Energy & Environment.1998 3. Molecular biotechnology 3rd edition ASM press Washington. Basic Biotechnology ± Tata McGraw Hill Publishers 7. P. Surrogate motherhood. 2004 8. 10th edition. Agriculture. Olive Kaiser . K. Biotechnology Fundamentals and Applications Student edition Agrobios .Rainer Muller.The Benjamin Cummins Publishing California. Purohit. S. Gupta. Russel.

(3 hrs per week) Sr. Razdan.Ltd. New Delhi. 2nd edition Oxford and IBH Publishing Co. IBH Publishing Co. and recent developments of following categories. structure activity relationship (SAR). 2nd edition New y AGE International (LP) Limited. 2nd edition. intracellular cyclic nucleotides and other mediators of biological response.I Hrs. Blood brain barrier. mechanism of action. nomenclature. distribution. 1 General considerations: Structure of biological membrane. No SECTION. Drug absorption. S. K. H. Ferguson principle. metabolism and elimination. y Pvt. 04 3 History and general aspects of the design & development of drugs includingclassification. solubility. Selectedphysicochemical properties affecting drug action. 3. Bioisosterism. Introduction of Plant Biotechnology. Pvt. Ashutosh Kar. . Introduction to Plant Biotechnology .H. Ltd.y Publisher. stereo chemical aspects of drug action.3 MEDICINAL CHEMISTRY ±I (Theory) 90 Hrs. Biochemical approaches in drug designing wherever applicable should be discussed. Protein binding. Chawala.2002 9. Pharmaceutical Biotechnology. 2007. New Delhi. adverse effects. M. therapeutic uses. Transduction mechanism. 06 2 Receptors: Types of receptors. Sambamurthy. 2002 10. Types of forces involved in drug receptorinteraction. 2003 11. partition coefficient.

Cardiotonic drugs b. Neuromuscular blockers 09 3.2 Adrenergic agonists and antagonists: Biosynthesis. Parkinson¶s disease b. Antiarrhythemic agents d. Antihypertensive agents e. Ganglionic blockers and nicotinic receptors.7 Drugs used in Neurodegenerative diseasesa. Analeptics and respiratory stimulants b. General anesthetic agents b. release and metabolism ofnoradrenaline. Ganglionic transmission. Cholinergic antagonists.Cholinergic agonists: Receptor subtypes and their structural features. Antidepressant agents c. 07 3. Antipsychotic agents b. impulse. Antimuscarinic agents:Ganglionic Blockers and neuromuscular blockers: Ganglionic stimulants. Anxiolytic agents Local anesthetic agents 05 3.Biosynthesis of acetylcholine.II 3.6 CNS Depressant Drugsa. Receptor subtypes and their structural features. its release and metabolism.9 05 . Currently used Anti-lipedemic drugs 12 3.8 06 3.5 CNS Stimulant Drugsa.3. Sedative & Hypnotic agents c. Hallucinogens 04 3. Antianginal agents c.3 Cardiovascular drugsa. cholinesterase inhibitors.1 Cholinergic agonists and antimuscarinic agents: Neurotransmitters. Anticonvulsants 06 3.4 61 Diuretic agents 05 SECTION. Alzheimer¶s disease Psychotherapeutic agentsa.

ondansetron. sodium valproic acid. terbutaline. Demonstration of construction of stereo models of drugs (minimum two) 6. haloperidol. molar refractivity and y RM values of compounds for QSAR analysis. alprazolam. dissociation constant. (3 hrs per batch) 1. glyburide. clofibrate. thiopental sodium. prazocin. guanethidine. captopril. Purification techniques of solvents/liquids by Fractional distillation and distillation under vacuum 2. dicyclomine hydrochloride. dantrolene sodium.10 3. furosemide. metazepine.13 4 Anti-migraine agents Diagnostic agents: Radio Opaque diagnostic agents.3. amitryptiline. chlorpromazine. Miscellaneous diagnostic agent. losartan. amiloride. Resolution of Recemic mixtures of any two APIs by any two methods 4. rosiglitazone. Two or more step synthesis of drugs and drug intermediates being studied in theory y (any ten) . imipramine. Agents for organ functiontest. Preparation of acid salts of drugs and evaluation of its physical properties. propranolol.3 (P) MEDICINAL CHEMISTRY ±I (Practical) (90Hrs. sumatriptan. diazepam. lignocaine. chlorthiazide.12 3. atenelol. methyldopa. soft drugs and hard drugs Scheme of synthesis of following drugs from various therapeutic categories:Carbachol. tolbutamide. hydralazine. 3. salbutamol.11 3. donepezil Total 02 03 05 03 08 90 3. Oral hypoglycemic drugs ( including insulin) Prodrugs. trifluperazine. Demonstration of simple QSAR software (Hansch Analysis) 5. 7. fluoxetine. Determination of partition co-efficient. phenytoin.

Vol. 1st edition. I Fundamentals and Applications in Chemistry and Biology by C Hansh and A Leo Vol. Lippincott William Wilkins. 11 Foye¶s Principles of Medicinal Chemistry by Foye. 9 Exploring QSAR Vol. 6th edition. 5 Wilson and Gisvold¶s Textbook of Organic Medicinal and Pharmaceutical Chemistry by Wilson and Gisvold.4 by Lednicer Daniel. . TATA McGraw Hill. 2 Bentely and Driver¶s Textbook of Pharmaceutical Chemistry by Atherden LM.Recommended Books for Theory and Practicals 62 1 An Introduction to the Chemistry of Heterocyclic Compounds. Philadelphia. Lippincot Co. Interscience Publishers New York. 1st edition. Vol I & II. 4 A Textbook of Pharmaceutical Chemistry by Chatten LG. 8th edition Oxford University Press London. J. 6 Stereochemistry of Carbon Compounds by Eliel EL. John Wiley & Sons INC. 32nd reprint 2005. I & II. Pearson Education. 3 Inorganic Medicinal and Pharmaceutical Chemistry by Block & Roche. 1. 7 The Organic Chemistry of Drug Synthesis. Electronic and Steric Constants by C Hansh. Marcel Dekker New York. 10 Organic Chemistry by Finar IL. Varghese Publishing House. Vol. by Acheson RN. 8 Profiles in Drug Synthesis Vol 1 & 2 by Gogate. II: hydrophobic.2. A Leo and D Hockman ACS Book Catalog..3.

17 Antibacterial Chemotherapeutic Agents by SL Dax. Mahadik KR. 1st edition. Thieme Publications. 3 edition. 22 Structure based Drug Design by Veerapandian. Willey-VCH Publication 1997. 23 Pharmaceutical Substances by Kleeman & Engel. 15 Computer Aided Drug Design. 18 Principles of Medicinal Chemistry by Kadam SS. 1st edition. Oxford. John Wiley & Sons.A Critical Introduction by Martin YC. Blackie Academic and Professional Publications. Academic Press. Nirali Prakashan. Taylor & Francis New York. 1997.12 Comprehensive Medicinal Chemistry by Hansh C. NY 16 Burger¶s Medicinal Chemistry by Wolff ME. New York. 4 edition. London. 19 Introduction to Medicinal Chemistry¶ ± How Drugs Act and Why by Alex Gringauz. th 24 Practical Pharmaceutical Chemistry by Beckett AH & Stenlake JB. Vol. 20 Drug Design by Bothara KG & Kulkarni VM. Bothara KG. Vol. I & II. Nirali Prakashan. New Age International Publishers. Elsevier Pergamon. I and II. by Pops and Perruns. 4th . Marcel Dekker Inc. Chapman and Hall. 14 Medicinal Chemistry-A Biochemical Approach by Nogrady T. 10th Edition. rd 21 An Introduction to Drug Design by SN Pandeya & IR Dimmock. Oxford University Press New York. 13 Quantitative Drug Design. New York. Vol IV.

63 29 Practical Organic Chemistry by Mann FC & Saunders BC. The English Language Book Society and Longman Group Limited. London. CBS Publication. 1st edition. The English language book society and Longman group limited.. Marcel Deckker Inc. McGraw Hill Book Co. A Leo and D Hockman. 30 Quantitative Drug Design ± A Critical Introduction by Martin YC. 3rd edition. 3. 32 Advanced practical Medicinal Chemistry by Ashutosh Kar. London. The ELBS Longman. New York. (3 Hrs. New York.4 (T) PHARMACEUTICAL ANALYSIS-II (Theory) 90 Hrs. ACS Book Catalog. John Wiley & Sons. 33 Vogel¶s Elementary Practical Organic Chemistry Small Scale Preparation by Arthur I. 25 Steric Constants by C Hansch. 26 Textbook of Practical Organic Chemistry. New Age International Publications. 31 Vogel¶s A Text book of Practical Organic Chemistry by Vogel./week) .2nd Edition.edition. New York. London. CBS Publisher & Distributor. 28 Jenkins¶s Quantitative Pharmaceutical Chemistry by Knevel AM and Digangi FE. Part-I. 27 Computer Software Application in Chemistry by Jurs PC.

Instruments for analysis. Linear Scan& Differential Pulse Polarography. applications covering nonaqueous polarography 5 6 Fluorimetry and phosphorimetry: ± Molecular luminescence. Flame types. Advantages and disadvantages of instrumental methods of analysis and respective problems. optical bleachers. Neutralization titrations and its applications. applications.TopicNo SECTION-I Hrs. quantitative aspects of fluorescence. 3 4 Electrophoresis ± Principle. half wave potential. measurement offluorescence. Principle. Instrumentation and Pharmaceuticalapplications 3 3 Refractometry: Specific and molar refraction. applications. Instrumentation line broadening. Titrimetricmethods. Instrumentation. 1 Introduction to analytical methods. different Interference and their Corrections. advantages and disadvantages. Spectrofluorometry Instrumentation. Dropping Mercury Electrode andOther Mercury Electrodes. factors affecting fluorescence. Refractive index. Complexometric reactions and titrations). advantages and disadvantages. Various types of Developments 5 5 Polarography: ± Introduction.Doppler effect. synchronous fluorescence. 12 . Pharmaceutical applications 4 Flame Photometry: Principles. (Gravimetric methods. Instrumentation. Instrumentation and applications. Measurementof RI (angle of refraction). 4 2 Atomic Absorption Spectroscopy: Theory. Polarogram. Excitation and emission spectra.

Development of TLC. grain direction. application. Ultraviolet and Visible absorption spectroscopy:. classification of instrumental methods. applications. Automated Multiple Development.origin and theory of UVspectra. advantages and disadvantages. Labeling of TLC. Optimum conditions for Spectrophotometric measurements. Spectrophotometric titration. Amperometric titration apparatus. Efficiency of column. theory. Amperometry: ± Principles. Instrumentation. Single beam and double beam UV ± Visible Spectrophotometer. Variations in Coulometric techniques. Column Chromatography: Principle.Visible spectrophotometry. Biamperometric titrations and its applications. ascent number. Coulorimetry at controlled potential. Activity of Adsorbents. Chromatographic selection ofmethod. Thin Layer Chromatography: Principle. preparation. General characteristics of Coulometric techniques. techniques. applications. Derivative Spectrophotometry. types ofCoulometric analysis. Capacity factor and other performance parameters. Fundamental laws of absorption. Column packing. Development. selecting an analytical method. Rotating Disc. Brief history. application. applications. classification. classification of analytical methods. elemental analysis. Coulometric Analysis: ± Introduction. Paper Chromatography: Technique. apparatus and general techniques. molecular analysis. Adsorbents. Van Deemter Equation in detail. Applications of UV. Different types of paper.7 Chromatography: Introduction. generalprocedure. 15 64 High Performance Thin Layer Chromatography (HPTLC): Theory. ring and similar types of electrodes 6 9 12 10 6 11 4 .Instrumentation and Applications. techniques for color comparison. Coulorimetric methods. Interaction of Electromagnetic radiation withmatter. Horizontal TLC and other development modes. Centrifugal TLC SECTION-II 8 Electromagnetic spectrum.

Flurometric estimation of few florescent compounds. Minimum Three exercises 4. Na+. Three exercises 2. per batch) 1. alkaloids Three exercises 6.A. applications. Conners. Definition.4 (P) PHARMACEUTICAL ANALYSES-II (Practical) (75 Hrs. Calcium and Lithium estimation from formulations by Flame Photometry. UV spectrophotometric estimations of API and same from their formulations Four exercises 3. Thermogravimetric Analysis (TGA): Introduction. Isothermal titration calorimetry Nephelometry and Turbidometry: Introduction Principle. Instrumentation. 3rd edition. applications. Nepheloturbidimetric estimation of few analytes containing ions. Paper chromatography ascending.Types. K+. Principle Instrumentation. 7 13 4 3. y Staenlake. th 2 A Textbook of Pharmaceutical Analysis by K. two exercises each for available filter 5.12 Thermal Analysis: Differential Scanning Calorimetry (DSC) Definition.H. 4 Edition. Instrumentation. vitamins. Principle. Differential Thermal Analysis (DTA): Introduction. fats and other similar samples also. Beckett and J. Determination of refractive index by Abbe¶s Refractometer Molar refraction calculations. Instrumentation. John Wiley and .B. Use oils . Definition. CBS Publisher & Distributor New Delhi. applications. Radial Three exercises each 7. Principle. Thin Layer chromatography Three exercises Recommended Books for Theory and Practicals 65 1 Practical Pharmaceutical Chemistry (Part I & Part II) by A. Types.Applications.

2 edition. CBS Publisher & Distributor. 14 Instrumental Methods of Chemical Analysis by BK Sharma. I and II). Ashkar. 4 A Textbook of Pharmaceutical Chemistry by L. Kennedy. 3 Principles of Instrumental Analysis by Skoog. 6 Introduction to Chromatography (Theory and Practice) by VK Srivastav and KK Shrivastav. 1st edition. Chatten. 3rd edition. 5 Principles of Chromatography by KR Mahadik. Vol I & II. Thomson Brookslcole. London. Marcel y Decker. New York. 13 Analytical Chemistry by Gary D Christian. 9 Vogel¶s A Text book of Practical Organic Chemistry by Vogel. by Faud S. Goel Publishing House. 8 Radio bioassays (Vol. Dean Settle.y Sons. 7 Pearson¶s Analysis of Foods by Ronald Kiek and Ronald Sawyer (Longman). H. y 11 Handbook of Instrumental Techniques for Analytical Chemistry by Frank Settle. 15 Analytical Chemistry: Principles. The y English language book society and Longman group limited. Practice Hall Publications. 7th edition. 5th edition. 2nd edition. K. John Wiley & Sons y Publications. John. 5th edition. nd . Nirali y y Prakashan. KG Bothara. 10 Macmillan Textbook of Physical Chemistry by Samuel Glasstone. y 12 Instrumental Methods of Analysis by Willard Merit.

Basic pharmacology (classification. 2001. mechanism of action. pharmacokinetics.I Hrs. 22. 3. New Delhi First Edition. II. 17 Practical Pharmaceutical Chemistry by Beckett AH & Stenlake JB. pharmacologicalactions. Y. 18 Indian Pharmacopoeia. contraindications. Pharma Med Press. dosage. therapeutic uses. 66 . latest edition 19 British Pharmacopoeia.Chandreshekhar. A Textbook of Analytical Chemistry. adverse effects. (3 Hrs. symptoms and treatment of poisoning) and Clinical Management of diseases and drugs acting on following categories: Autonomic Nervous System a) Autonomic Nervous system-General Considerations b) Cholinergic system and drugs 1. 4th edition. K. Vol. CBS Publisher & Distributor and I./week) Sr. drug interaction. Anjaneyulu. latest edition 20 United States Pharmacopoeia latest edition 21 High Performance Thin layer Chromatography. No SECTION. Valli y Manickam.16 Remington The Science and Practice of Pharmacy. Quantitative Analysis of Pharmaceutical Formulations by PD Sethi.5 (T) PHARMACOLOGY (Theory) 90 Hrs. CBS Publisher & Distributors. Lippincott Williams y y & Wilkins. 20th edition.

SECTION. opioids.c) Anti-cholinergic drugs d) Neuromuscular blocking agents e) Adrenergic system and drugs f) Anti-adrenergic drugs g) Ganglion stimulants and blockers 20 2. antidepressant.Alcohol. anti-anxiety. tobacco. Drugs acting on Central Nervous System y y 25 a) Aliphatic alcohol b) General anesthetics c) Sedative and Hypnotics d) Antiepileptic drugs y y e) Anti-Parkinsonian drugs f) Drugs used in Mental illness (Psychopharmacological drugs)Antipsychotic. anti-mania drugs g) Opioid analgesics and antagonists h) NSAIDs i) CNS stimulants and nootropic j) Drug dependence y k) Introduction to Patient addiction rehabilitation Center and Principle of rehabilitation of drug addicts.II 3 Drugs acting on Respiratory tractDrugs for cough and bronchial asthma 04 4 Drugs acting on gastrointestinal tract a) Drugs for peptic ulcers b) Emetics and antiemetics 08 .

glucagon e) Gonadal hormones and Oral contraceptives. antifertility agents f) Oxytocin and drugs acting on uterus. rheumatoid arthritis and osteoarthritis. . OECD guidelines. Study of various anesthetics employed to anesthetize laboratory animals. Vitamine D d) Insulin. animal welfare and introduction of y y CPCSEA and its guidelines. drugs regulating calcium homeostasis. Care and handling of common laboratory animals. Oral hypoglycemic agents. parathyroid hormones. 06 7 Local Anesthetics 02 3. 3.II (Practical) (90 hrs: 3 hrs/week) 1.c) Drugs for constipation and diarrhea 5 Hormones and Hormones antagonists a) Anterior and Posterior Pituitary hormones b) Corticosteroids and corticosteroid antagonists c) Thyroid and antithyroid drugs. Introduction to commonly used instruments in experimental pharmacology. 4. 25 6 Pharmacotherapy of gout. 2. Introduction to animal physiology with their biochemical reference values in various animal species.5 PHARMACOLOGY.

Computer simulations of following experiments through computerized simulated software programme using software such as X-Pharma. b) Study of locomotor activity of drug using actophotometer. a) Study of analgesic activity of drugs using Eddy¶s hot plate analgesiometer. body fluids and urine from experimental animals. X-cology etc. . 7. drug solution and use of molar solution in various animal experiments. d) Study of muscle relaxant property of drug using rotarod. types. 9. 10. Study of various routes of drug administration 6. Principle. c) Study of drug antagonism using isolated tissues. advantages of various methods 11. c) Study of anticonvulsant activity of drug using maximal electroshock/ y pentyleneterazol/ strychnine/INH method.67 5. Bioassay-Definition. Bioassay of Acetylcholine and histamine using suitable animal preparation 12. stunning and pithing 8. Study of various methods for collection of blood. Introduction to the techniques of Euthenesia. Study of physiological salt solutions. Behavioral pharmacology demonstrations using various instruments preferably by simulations on computers (A small number of mice (3) to be used for each the following experiments and the animals should not be sacrificed). tail immersion. y a) Record and interpret the concentration response of acetylcholine/histamine using suitable isolated tissues. d) Study of the miotic and mydriatic effect of drugs using rabbit eyes e) To study effects of various cardiovascular drugs on following heart preparations. b) Study of synergism using isolated tissues.

e) Study of various drugs on sleeping time using suitable animals.G.s Modern Concepts on pharmacology and Therapeutics. Ghosh. Satoskar . Recommended Books 1. Churchill Livingston. Bodhankar. Sharma K. Bombay).. Pharmacology and Pharmacotherapeutics (Popular Prakashan. F. Lange Medical Publisher. M. Paras Publication. Rang.R. General Pharmacology Basic Concepts. New York) 5. Jaypee. R. Nirali Prakashan. 3. Essentials of Pharmacotherapeutics. 10. and Dale. Barar. Crossland. M. Das. USA 8. Boston 4. Chand and Company. Craig. James and. 68 . Katzung. (Pergamon Press. NS. Modern Pharmacology. Pune. g) Study of Haloperidol/ Clonidine/ Petazocin induced catalepsy using suitable animal. McGraw-Hill 7. Calcutta ) 6.. D.D. K. UK 9. Tripathi K. and Dutta S.K.. Goodman and Gilman. Pharmacological Basis of Therapeutics. B. A textbook of Pathophysiology. B. M. Basic and Clinical Pharmacology. : R. ( HILTON and Co.s Pharmacology Basis of Therapeutics.P. Pharmacology. 11. and Bhandarkar S. K. and Stitzel. S.S. Lewis.E. SL and Vyawahare. New Delhi 2.S. Medical Pharmacology. C.L. H. Little Brown and Co.M. Sharma H. f) Study of local anesthetic effect of drugs using suitable animal.

general biogenetic pathway. Note: ± Drugs mentioned in Bold must be studied in detail for their cultivation. classification. . occurrence. general methods of extraction and evaluation of volatile oils. classification. general biogenetic pathway. occurrence. collection and extraction Glycosides ± Introduction. A) Terpenoids ± Introduction. definition./week) Sr. uses.6 (T) PHARMACOGNOSY (Theory) 90 Hrs. Rhubarb ‡ Cardioactive ± Digitalis. chemistry. classification . ‡ Coumarin/ furocumarin ± Psoralea ‡ Lactone ± Artemesia 2. properties. dioscorea . occurrence. chemistry. 12 20 1. uses. Kalmegh.Quassia. properties.uses . Squill ‡ Saponins ± Liquorice.3. (3 Hrs. B) Volatile Oils ± Introduction.I Hrs. chirata ‡ Cynogenetic ± Bitter almond ‡ Isothiocyanate ± Black mustard ‡ Flavonoid ±Orange peels. No SECTION. General extraction and isolation methods. properties. shatavari ‡ Bitter. ‡ Anthraquinones ± Senna. Aloe.

Tannins ± introduction. Wool fat. Ginger. Capsicum. SECTION. Seasame oil. Amala. cinnamon. cassia. Streptokinase. Kaolin. soya oil. gelatin.Castor oil. coriander. classification. 3 . Asafoetida. Enzymes and proteins ± Papain. olive oil. 3 9. properties. definition. and uses. Ashoka . fennel. 3. methods ofextraction. Turmeric. occurrence. clove. tulsi. Bromelin.Pale catechu . Linseed oil. Derris root. Cannabis. classification. Plant pesticides ± Pyrethrum. uses. Guggul 8 7. Black catechu 8 6. Neem.chemical composition extraction. Bentonite. chemicaltests and general method of extraction.Serratiopeptidase. Podophyllum. Myrobalon . properties. Drugs of mineral origin ± Shilajit. Resins and resins combinations ± introduction. Fixed Oils. Urokinase . Shark liver oil. Shellac. General methods to study the biogenetic pathways with special reference toTracer Technique and its application in the biogenetic investigations with suitable examples. Benzoin. lavender. nutmeg. Carnauba wax 8 4. dill. adulteration.Bahera. eucalyptus. Cod liver oil. Kokum butter Waxes ± Bees wax. general biogenetic pathway. Colophony.Fats ± Cocoa butter. properties. Fullers earth. 3 8. Tobacco. caraway. evaluation. uses. Arjuna .II 5 5.Cardamom. Calamine. classification. Lipids ± introduction.

M. The British Pharmacopoeia.10. Gowel Publication house 7. . : Textbook of Pharmacognosy: CBS Publisher and Distributor 4. New Delhi 3. Froth floating technique. Tyler. Pune. 8. Droplet-countercurrentExtraction. 2. Recommended Books 1. Saunders Company. 12 11. Iyangar: Study of Crude Drug.. A.P agrawal. Transgenic plants . Chemodemes. 9. Wallis T. 1996 & 2007.Soxhlet extraction. Chemistry of Organic Natural Products by O. Extraction of Plant Material. 15/ Ed. ‡ Conservation of Endangered species through micropropagation. Purohit. Rangari: Pharmacognosy: Career Publications 6. Gokhale: Pharmacognosy: Nirali Prakashan. Supercritical fluid extraction. London. Brady and Robbers: Pharmacognosy: CBS Publisher and Distributors. 5. Kokate. Applications of Medicinal Plant Tissue Culture in Pharmacognosy.‡ Cultivation of Medicinal Plant Cells ‡ Production of Secondary Metabolites ‡ Bioconversions Using Plant Cells ‡ Plant Cell Immobilization ‡ Genetic manipulation: Mutation. Hybridisation.Polyploidy. Trease and Evans: Pharmacognosy. Evaluation 3 69 of herbal extract. The Indian Pharmacopoeia. E.

stomata. digitalis. 17. Iyengar.Cassia/ Cinnamon ‡ Fruit. M. Street H E. Rainerat and Bajaj. Manipal. starch grains and calcium oxalate crystals. 15.6 Pharmacognosy. trichomes. E. Iyengar. y y y y ‡ Leaf ± Senna.Fennel/ Caraway/ Dill/ Coriander/ Cardamom/ Capsicum.An Introduction to Plant Tissue Culture.10. Pharmacognosy/ 14.Books and Allieds Pvt Ltd. 11. G. Martindale: The Extra Pharmacopoeia. K Nayak ³Pharmacognosy Lab Manual´. Vasudevan & K.K Nayak ³Anatomy of Crude Drugs´ Manipal press. Razdan M. Laddha ³Herbal Drug Microscopy´ Yucca Publication. chemical and micro chemical tests for following crude drugs in entire and in powdered form (including surface preparation wherever required). Ramstad: Modern Pharmacognosy: McGraw Hill Book Company. 20. 13. 12. A.A.Manipal Press. T. S. S.G. 19. M.S. 3. Eucalyptus (Comparitive study) ‡ Bark. N: Indiustrial Pharmacognosy. plant tissue culture..K. Tissue culture and plant science.Isapghula/ Linseed . Kalia A.. Satyanarayana ³Biotechnology´. INC. Academic press. ‡ Seed.II (Practical) (90 hrs: 3 hrs/week) 1) Study of plant tissues. 16.Oxford publisher 18. Mohammad Ali. y 2) Analytical study of morphological and microscopical characters. Manipal.M. London.

Ginger. B) Identification of unorganized drugs by physical characteristics and chemical Tests. aloe. Benzoin. Pharmacognosy. y . Extractive values. Guggul. Pune.Clove ‡ Wood. Shatavari. Swelling index. Determination of Leaf constant. Gokhale. Honey.Quassia ‡ Stem ± Kalmegh/ Chirata ‡ Root and Rhizomes ± Liquorice. 7) A) Identification of crude drugs mentioned in theory syllabus from their morphological and physical characters and preparation of herbarium for one medicinal plant. width and diameter of cellular material! cell contents. Determination of length. Recommended Books 1. Determination of % purity of crude drugs by lycopodium spore method 4) Experiments on ± Sampling of crude drug for analysis. Moisture cotent (Loss on drying! Toluene Distillation) Ash Values. (Comparitive study) 70 3) Quantitative microscopy: . Catechu. Kokate. Nirali Prakashan. Veinlet termination no. Determination of foreign matters. Colophony. Foaming index. Vein-islet no. Palisade ratio.Stomatal number and Stomatal index. Crude fibre (by dutch method) 5) Estimation of Acid Value! Saponification value! Iodine Value 6) Identification of natural fibres by general chemical tests and microscopical examination. Castor oil. . Shellac.. Tragacanth Detection of adulteration in oils 9) Visit to a tissue Culture Laboratory. Asafoetida. Acacia. Agar. Purohit. .y y y y ‡ Flower bud.

G. Fundamentals of management i) Management basic Concepts efinition. 1. planning process.Nirali Prakashan. Cultivation and utilization of medicinal plants. Martindale Extra Pharmacopoeia.2. S.R. Modern Pharmacognosy. Iyengar.7 (T) Pharmaceutical Business Management (Theory) 60 Hrs. Pharmacognosy & Phytochemistry.I Hrs. Ayurvedic Pharmacopoeia. Contribution of Taylor. 3 3 . (2 Hrs. 1. Pridham J B. A. S. Functions and responsibilities of a manager. Mc-graw hill Book Company.Pune. Wealth of India 8.types of planning.A. M. Materia Medica by Nadkami. Rangari V D. M. 6. No SECTION.K Nayak ³Anatomy of Crude Drugs´ Manipal press. 10. 9. Manipal. Peter Drucker in modern management. 7. Manipal./week) Sr. Swain B. II. 4. ii) Planning: Nature and purpose of planning.Practical Pharmacognosy. 11.G. Fayol. Career. Academic Press. 3. 14. 5. 71 3. 13.Attal and Kapoor. Management thoughts. advantages and limitations. Shah & Quadry. Indigenous drugs of India. Vol I. A text book of Pharmacognosy. New york. Function of management. important steps in planning. Chopra. K Nayak ³Pharmacognosy Lab Manual´. E Ramstad. Iyengar. Biosynthetic pathways in higher plants. 12. Manipal Press. British Pharmacopoeia. Need for management. Khandelwal K.

Channels of distribution. Delegation. Network techniques (PERT & CPM).II 1. objectives andprincipals of purchasing. Manage±ment information system. Labor law.Departmentalization.Sales forecasting methods. Management byobjectives. Wholesale. Job satisfaction. Causes of disputes.A. Tribunals. Decision making process vi) Controlling: Concepts and purpose of control techniques. Lock outs. iii) Objectives: Types of objectives. Balance sheets 2. Importance and function of Q. Current status and growth scenario. Clinical research organization. basic principals of organization. inventory control.C and Q. iv) Material management: Classification of materials. advantages and limitations. Break even analysis. Drug discovery process. 3. Decentralization. Policies. Retail. Introduction to Factories Act. Drug developmentprocess. Profit and loss account. Budgetary andnon budgetary control. Scope. Importance of objective. Industrial relations. Personal counseling. ii) Operation management in Pharmaceutical Industry: Controlling ofmanufacturing operation. Departmental.1948. Definition and Importanceof decision making. Pharmaceutical industry and operation managementi) Historical perspective of pharmaceutical industry in India. Line & Staff organization. 1. Trade unions Act 1926 and Industrial Disputes Act 1947. 2 2 2 3 1 2 3 3 5 3 . Advantages and Limitations iv) Organizing: Organizational structure. v) Decision making: Types of strategies. Strikes. iii) R&D in Pharma industry. SECTION. Pharmaceutical Marketingi) Difference between marketing and selling. analysis. Management audit. 3. Staffing.Meaning. Trade unions.

functions. registration authorities.ii) Sales promotions. importance. leadershipstyles. trait theory. Ethics of sales. documentation. iv) Marketing research: Nature & Importance v) Product management: Product life cycle. Merchandising. Detailing iii) Medical representative: Role & Qualities. regulatory agencies Recommended Books 1) Peter Drucker. formsof communication. 3. Equity or social comparison theory X & Y. recruitment and training 3. Harper and Row. New York. types of communication iv) Interview techniques: ± presentation skills . 4 3 2 2 2 2 .Needs & Methods. International market. Objective.types of price 2. Launching a new product. 72 3 1 2 3 Branding. procedure. Expectancy theory.group discussion v) Performance appraisal: need and techniques. Factors affecting . 1954. Packaging vi) Price: Definition.Advertising. Hertzberg¶s theory.Pharmaceutical export. 3 2. Principles & Techniques. Export. Human Resource and Developmenti) Motivation: definition. communication process. concept. Theory¶s.Maslow¶s Theory. Vroom¶s theory. procedure for determination of price. managerial grid iii) Communication: importance. qualities of leadership. ii) Leadership: definition. The Practice of management. Reinforcement theory.

3rd Edition. Essentials of Management.C. Marketing A Managerial Intoduction. 2005. Principles of Marketing. Singapore. Prentice Hall of India Pvt. New Delhi. 7) Philip Kotler & Gary Armstrong. 1995. 2001.. New Delhi. 2nd edition. 1998. 9) J. Pearson Education Pvt. 73 . New Delhi. 4) Koontz H. New Delhi. Gandhi. 15) Marketing in New Millennium by Dr. Principals of Management. 11th Edition. Hyderabad. 10th Edition. Ltd. Tripathi & P. 10) Mickey Smith. 12) Cost Accounting & Management Accounting: Everest Publication. 14) Marketing Management by Philip Kotlar. 5th edition. 11) Horngren. New Delhi. 2005. J. M.. 13) Principles and Methods of Pharmacy Management by Harry Smith. 2000. Viva Books Pvt. 2001. Introduction to Management Accounting. 3) P.2) Harold Koontz. Tata McGraw Hill publishing Co/ Ltd. 1998. Management. Tata McGraw Hill publishing Co/ Ltd.N.. Ltd. Ltd. CBS Publisher & Distributors. 7th edition. Pharmaceutical Marketing in the 21th Century. The world Press Pvt. Tata McGraw Hill publishing Co/ Ltd. 1998. 8th Edition New Delhi. 6) G. Xavier. An Introduction to Management. New Delhi. Calcutta. 5) Satya Saran Chatterjee. Sundem & Stratton. Ltd. Mickey Smith. Pharmaceutical Industrial Management. Vidyasagar. Reddy. Pharma book Syndicate.. 16) Principles and Management: Koonz O¶ Donnel. Principles of Pharmaceutical Marketing. 12th Edition. & Weihrich H. Cyril O¶Donnel & Heinz Weihrich. 1980.C.

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