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chemwerth. Mykrox.Sponsored Links Alosetron API. D290250 www.moore@chemwerth. action: acts on distal tubule by increasing excretion of water.. uses: edema. þÿ • Browse: Unanswered questions Most-recent questions Reference library Enter question or phrase. FDA approved German mfg dave. and potassium. CHF. sodium. English▼ • • Search unanswered Desloratadine TRC manufactures Desloratadine plus labelled compound. Cat... Search: All sources Community Q&A Reference topics þÿ • Browse: Unanswered questions New questions New answers Reference library Sponsored Links Nadroparin Calcium Tiandong-special manufacturer of Nadroparin Calcium. buy now & save! Home > Library > Health > Dental Dictionary n trade names: Diulo. drug class: diuretic with thiazidelike Related Videos: . chloride.trc-canada. Zaroxolyn.

Tableta oral Metolazone Oral tablet What is this medicine? METOLAZONE (me TOLE a zone) is a diuretic. What should I tell my health care provider before I take this medicine? . This medicine may be used for other purposes. which causes the body to lose salt and water. This medicine is used to treat high blood pressure. It increases the amount of urine passed. It is also reduces the swelling and water retention caused by heart or kidney disease. ask your health care provider or pharmacist if you have questions.Metolazone Top Drug Info: Metolazone Top Home > Library > Health > Drug Info Brand names: Mykrox®Zaroxolyn® Chemical formula: Español: • Metolazona.

Remember that you will need to pass urine frequently after taking this medicine. like lupus •kidney disease •liver disease •pancreatitis •small amount of urine or difficulty passing urine •an unusual or allergic reaction to metolazone. . other medicines. herbs. Do not take at bedtime. What may interact with this medicine? •alcohol •antiinflammatory drugs for pain or swelling •barbiturates for sleep or seizure control •digoxin •dofetilide •lithium •medicines for blood sugar •medicines for high blood pressure •medicines that relax muscles for surgery •methenamine •other diuretics •some medicines for pain •steroid hormones like cortisone. Follow the directions on the prescription label. sulfa drugs. Talk to your pediatrician regarding the use of this medicine in children. Do not share this medicine with others. Some items may interact with your medicine. Give your health care provider a list of all the medicines. dyes. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. and prednisone •warfarin This list may not describe all possible interactions. non-prescription drugs. Do not take your medicine more often than directed.They need to know if you have any of these conditions: •diabetes •gout •immune system problems. Take your medicine at regular intervals. foods. NOTE: This medicine is only for you. or preservatives •pregnant or trying to get pregnant •breast-feeding How should I use this medicine? Take this medicine by mouth with a glass of water. Also tell them if you smoke. or dietary supplements you use. Do not stop taking except on your doctor's advice. Special care may be needed. hydrocortisone. or use illegal drugs. Do not take your doses at a time of day that will cause you problems. drink alcohol.

chest pain •feeling faint •fever. blistering. tongue. nausea and vomiting. This medicine can make you more sensitive to the sun. use machinery. cramps •nausea. You may need to be on a special diet while taking this medicine. Do not stand or sit up quickly. peeling or loosening of the skin. hives. or if you sweat a lot. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her. or throat •fast or irregular heartbeat. including inside the mouth •unusual bleeding or bruising •unusually weak or tired •yellowing of the eyes. Avoid alcoholic drinks. You may get drowsy or dizzy. If you have diabetes. vomiting •numbness or tingling in hands. Alcohol may interfere with the effect of this medicine. or do anything that needs mental alertness until you know how this medicine affects you. The loss of too much body fluid can make it dangerous for you to take this medicine. wear protective clothing and use sunscreen. Check with your doctor or health care professional if you get an attack of severe diarrhea. feet •pain or difficulty when passing urine •redness.What should I watch for while using this medicine? Visit your doctor or health care professional for regular checks on your progress. This medicine may affect your blood sugar level. Do not drive. What side effects may I notice from receiving this medicine? Side effects that you should report to your doctor or health care professional as soon as possible: •allergic reactions such as skin rash or itching. check with your doctor or health care professional before changing the dose of your diabetic medicine. skin Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): •abdominal pain •blurred vision •constipation or diarrhea •dry mouth . swelling of the lips. Do not use sun lamps or tanning beds/booths. Keep out of the sun. This reduces the risk of dizzy or fainting spells. If you cannot avoid being in the sun. chills •gout pain •hot red lump on leg •muscle pain. Check your blood pressure as directed. Ask your doctor. mouth. especially if you are an older patient.

bulk and laboratory sales www. This drug information does not cover all possible Wikipedia: Metolazone Top Home > Library > Miscellaneous > Wikipedia Metolazone . not substitute for. Protect from light.etichem. Last updated: 7/1/2002 Important Disclaimer: The drug information provided here is for educational purposes only. Sponsored Links Methysergide Chemical raw material ETI . Where should I keep my medicine? Keep out of the reach of children. It is intended to supplement. treatment and advice of a medical professional. side effects and High blood pressure Find accurate and free articles by leading doctors Provocholine® Methacholine Chloride Powder Inhalation Diagnostic for Asthma www. You may report side effects to FDA at 1-800-FDA-1088. the diagnosis. precautions. Call your doctor for medical advice about side effects.cowurine. Throw away any unused medicine after the expiration date. It should not be construed to indicate that this or any drug is safe for Veterinary Dictionary: metolazone Top Home > Library > Animal Life > Veterinary Dictionary A diuretic and saluretic.provocholine. Keep container tightly closed. Consult your medical professional for guidance before using any prescription or over the counter drugs.High BP A natural supplement by Ayurveda No side effects no complications www. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Sponsored Links Hypertension .•headache This list may not describe all possible side effects.

Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide. but these highly effective combinations can lead to dehydration and electrolyte abnormalities.2-dihydroquinazoline6-sulfonamide Identifiers CAS number ATC code PubChem DrugBank 17560-51-9 C03BA08 CID 4170 APRD01109 Chemical data Formula Mol.4-oxo-1.835 g/mol Pharmacokinetic data Bioavailability Metabolism Half-life Excretion ~65% minimal 14 hours primarily urine Therapeutic considerations Pregnancy cat. Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila. Zaroxolyn. a muscle relaxant. mass C16H16ClN3O3S 365. It is primarily used to treat congestive heart failure and high blood pressure. This lowers blood pressure and prevents excess fluid accumulation in heart failure. so that blood volume decreases and urine volume increases. Contents [hide] • • 1 History 2 Structure . Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney.Systematic (IUPAC) name 7-chloro-2-methyl-3-(2-methylphenyl). Legal status Routes B Prescription only Oral (what is this?) (verify) Not to be confused with Metaxalone. and Mykrox.

S. Structure Metolazone is a quinazoline. or thiazides for short.2. act on the same target as thiazides and behave in a similar pharmacologic fashion.[2] Mechanism of action Schematic of a nephron. However.1-dioxide (benzothiadiazine). Therefore. and therefore is not technically a thiazide. and in the development of new medicines. a derivative of the similar diuretic quinethazone. The distal convoluted tubule is labelled "2nd convoluted tubule" (the proximal convoluted tubule is the first) in this illustration. since metolazone. Food and Drug Administration review drug applications. Bola Vithal Shetty has been active in helping the U. they are often included in the thiazide diuretics despite not being thiazides themselves. . It is related to analogs of 1. metolazone is not a substituted benzothiadiazine.• • • • • • • 3 Mechanism of action 4 Pharmacodynamics 5 Use 6 Toxicity 7 Chemistry 8 References 9 External links History Metolazone was developed in the 1970s. Chemically.4-benzothiadizine-1.[1] Metolazone quickly gained popularity due to its lower renal toxicity compared to other diuretics (especially thiazides) in patients with renal insufficiency. as well other drugs like indapamide. they are considered "thiazide-like diuretics". Indian born chemist Dr. Its creator. These drugs are called benzothiadiazides. as well as a sulfonamide.

As sodium is pumped out of the cell by the ATPase. and therefore water too. and low blood pressure. The distal convoluted tubule cells also possess a sodiumchloride symporter on the apical side. among other adverse effects. In addition to preventing fluid buildup. they can be associated with low sodium levels. and additional sodium begins to diffuse in from the tubule lumen as replacement. water remains in the lumen and is excreted as urine. of the nephron tubule. where they inhibit the sodium-chloride symporter. instead of being reabsorbed into the bloodstream. The water and chloride. volume depletion.[2] Use One of the primary uses of metolazone is for treating oedema (fluid retention) associated with congestive heart failure (CHF). excess chloride and potassium passively diffuse out the cell through basolateral channels into the interstitial space. metolazone remains active even when the glomerular filtration rate (GFR) is . metolazone or another diuretic may be used alone. Water passively follows to maintain isotonicity. Its half-life is approximately fourteen hours.The primary target of all thiazide diuretics. The primary form of excretion is in the urine (around 80%). As a result. Metolazone is around ten times as potent as hydrochlorothiazide. Although most thiazide diuretics lose their effectiveness in renal failure. will be absorbed into the bloodstream. absorbing some material and excreting others. blood is filtered into the lumen. the remaining fifth is evenly split between biliary excretion and metabolism into inactive forms. In the kidney. tubule cells in the distal convoluted tubule possess the ATP-powered sodium-potassium antiporter (Na+/K+-ATPase). similar to indapamide but considerably longer than hydrochlorothiazide. In mild heart failure. or open space. One side of the cell (the apical side) faces the lumen.[2] Nevertheless. and water accompanies them. as well as the sodium pumped out by the ATPase. As with other regions. Pharmacodynamics Metolazone is only available in oral preparations. the use of metolazone may allow the patient to relax the amount of sodium restriction that is required. Whatever remains in the tubule will travel to the bladder as urine and eventually be excreted. including metolazone. Since most of the sodium in the lumen has already been reabsorbed by the time the filtrate reaches the distal convoluted tubule. or combined with other diuretics for moderate or severe heart failure. is the distal convoluted tubule. thiazide diuretics have limited effects on water balance and on electrolyte levels. Approximately 65% of the amount ingested becomes available in the bloodstream. which uses energy from ATP to transfer three sodium ions out from the basolateral surface (toward blood vessels) while simultaneously transferring two potassium ions in. its intracellular concentration falls. Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter. The cells lining the tubule modify the fluid inside. The other sides are tightly joined to neighboring cells. The symporter requires chloride to be transported in as well. part of the nephron in the kidney. preventing sodium and chloride. which passively allows one sodium ion and one chloride ion to diffuse together in from the lumen (where urine is forming) into the cell interior. from leaving the lumen to enter the tubule cell. the opposite side (the basolateral side) faces the interstitial space near blood vessels.

though rare. those with hypersensitivity to sulfonamides ("sulfa allergy") may also be allergic to metolazone. "The Seventh Report of the Joint National Committee on Prevention. pancreatitis. Various electrolyte abnormalities may result.[2] Chemistry . Metolazone is frequently prescribed in addition to the loop diuretic. and Treatment of High Blood Pressure" (JNC 7) recommends thiazide diuretics as the initial medication for treatment of hypertension. agranulocytosis. hypercalcemia (high calcium). are sulfonamides. including hyponatremia (low sodium). and hyperuricemia (high uric acid). Evaluation. headache. are very often used alone as first-line treatment for mild hypertension. These may result in dizziness. They are also used in combination with other drugs for difficult-to-treat or more severe hypertension. Removal of too much fluid can cause volume depletion and hypotension. although as mentioned above metolazone is used in patients with moderate renal failure. especially by interacting with medicines used to treat gout. including metolazone. the loop diuretic will act at the loop of Henle. In addition. and angioedema. The other major use of metolazone is in treating hypertension (high blood pressure). they can be responsible for abnormalities of water balance and electrolyte levels. Detection. This gives it a considerable advantage over other thiazide diuretics.below 30–40 mL/min (moderate renal failure).[2] Serious. diuretic effects will occur at two different segments of the nephron. Chronic renal failure causes excess fluid retention that is often treated with diet adjustments and diuretics[3] Metolazone may be combined with other diuretics (typically loop diuretics) to treat diuretic resistance in CHF. since renal and heart failure often coexist and contribute to fluid retention. such as chronic renal failure or the nephrotic syndrome. chronic renal failure.[2] Toxicity Since thiazide diuretics affect the transport of electrolytes and water in the kidney. like other thiazide diuretics. and metolazone will act at the distal convoluted tubule. Metolazone. Thiazide diuretics. Hydrochlorothiazide is by far the most commonly used.[3] Metolazone may also be used in renal (kidney) disease. and nephrotic syndrome. or heart arrhythmias (palpitations). though usually not metolazone. Metolazone may be used for edema caused by liver cirrhosis as well. hypomagnesemia (low magnesium).[4] Metolazone and a loop diuretic will synergistically enhance diuresis over the use of either agent alone. hypochloremia (low chloride). thiazide diuretics. namely. hypokalemia (low potassium). side effects include aplastic anemia. as it is both better-studied and cheaper (about four times) than metolazone. may unmask latent diabetes mellitus or exacerbate gout. Using this combination.

doi:10. 2006. PDF. edited by Dennis L. 2006. Fedorchuk. New York: McGrawHill.. Journal of Medicinal Chemistry 13: 886. Eugene. New York: McGraw-Hill.ijp-online. 15th ed.pdf [PDF]. et al. Telfer L.and 3-aralkyl-1. Campanella. • [show] v•d•e Symporter inhibitors . Accessed on January 25. CARD=APRD01109. • http://www. 3. PMID 16189620. ^ a b Braunwald.ncbi.issue=1. A.cgi?cid=4170. T.nlm.volume=6. 2006. "Chemistry Reviewer Still in Lab". "Heart Failure and Cor Pulmonale".. 4. References 1. edited by Laurence L. M. Accessed on January 25. Volume 2. Gustafsson F. Galatius S. In Harrison's Principles of Internal Medicine.. In Goodman & Gilman's The Pharmacological Basis of Therapeutics. • http://redpoll. Edwin K.nih. 2. "Synthesis and activity of some 3-aryl. External links http://pubchem.. Michelson. "Diuretics".asp?issn=02537613. Zimmerman. "Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature.. Accessed on January 25. H. L. & Hildebrandt PR. 11th ed. 2006. News Along the Pike (newsletter of the Food and Drug Administration' s Center for Drug Evaluation and Research). 2005 Brunton et Kasper et al..type=0.. Accessed on January 25. David B. Accessed on January 25." Cardiovascular Drugs and Therapy. ^ a b c d e f *Jackson.Shetty.year=1974. Liborio A.txt.19(4):301-6.centaurpharma. E. Bola V. Thomas.aulast=Vithal. Issue 10. ^ Rosenberg J. (1970).1021/jm00299a022. 2006. Volz..4-tetrahydro-4-oxo-6-quinazolinesulfonamides". Davidson. ^ Katague. • http://www.spage=40.2.

a. Plasma Protein-Binding RED Device is a patented technology for plasma protein-binding studies . u.[show] v•d•e Antihypertensives: diuretics (C03) CA inhibitors Acetazolamide (at PT) Loop (Na-K-Cl Furosemide# • Bumetanide • Torasemide • Etacrynic acid at AL) Thiazides (Na-Cl at Hydrochlorothiazide# • Bendroflumethiazide • Hydroflumethiazide • DCT. C4.v:h. l. l)/phys/devp noco/syva/cong/tumr. a. u. Chlorothiazide • Polythiazide • Trichlormethiazide • Cyclopenthiazide • Calcium.desert-bio. t. drug(C3. It may not have been reviewed by professional editors (see full disclaimer) Donate to Wikimedia Sponsored Links Aprotinin Bovine Aprotinin at Great Prices & First Class customer service www.Methyclothiazide • Cyclothiazide • Mebutizide sparing) Thiazidelikes Quinethazone • Clopamide • Chlortalidone • Mefruside • Clofenamide • (primarilyMetolazone • Meticrane • Xipamide • Indapamide • Clorexolone • Fenquizone DCT) ESC blockers Amiloride# • Triamterene • Benzamil Aldosterone Spironolactone# • Eplerenone • Potassium canrenoate • Canrenone antagonists M: VAS anat(a:h. C9) This entry is from Wikipedia. C5. the leading user-contributed encyclopedia. sysi/epon proc.

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