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PATHOPHYSIOLOGY

Schematic Diagram Precipitating


Environmental conditions (open spaces with water
Predisposing pots, and plants)
Geographical area – tropical islands in the Immunocompromise
Pacific (Philippines) and Asia Mosquito carrying dengue virus
Soldier
Sweaty skin

Aedes aegypti (dengue virus carrier): 8-


12 days of viral replication on mosquitos’
salivary glands

Bite from mosquito (Portal of Entry in Redness & itchiness in


the Skin) the area

Allowing dengue virus to be inoculated


towards the circulation/blood (Incubation
Period: 3-14 days)

Virus disseminated rapidly into the blood Diagnostic:


and stimulates WBCs including B Hematology :
lymphocytes that produces and secretes Increased WBC:
immunoglobulins (antibodies), and 12,900/cumm
monocytes/macrophges, neutrophils (5,000- 10,000/cumm)
Increased
Lymphocytes: 49% (20-
40%)

Diagnostic:
Hematology :
Decreased
Monocytes:
4%(8-14%)
Decreased
Neutrophils:
49%(50-70%)
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Antibodies attach to the viral
antigens, and then
monocytes/macrophages will
perform phagocytosis through Fc
receptor (FcR) within the cells and
Entry to the Entry to the
dengue virus replicates in the cells
spleen, and bone marrow
liver
Recognition of dengue viral
antigen on infected monocyte
by cytotoxic T cells

Release of cytokines which consist of


vasoactive agents such as interleukins,
tumor necrosis factor, urokinase and
platelet activating factors which
stimulates WBCs and pyrogen release

Signs/ symptoms:
Febrile: 38.6C
Diaphoresis, warm skin, Dengue
flushed; headache of
3/10 pain scale; whitish Fever
spots; body weakness
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Virus ultimately targets liver Cellular direct destruction and


and spleen parenchymal cells infection of red bone marrow
Diagnostic:
Ultrasound: where infection produces precursor cells as well as Diagnostic:
minimal apoptosis/cell death immunological shortened platelet Hematology :
hepatospleno survival causing platelet lyses Decreased
megaly Platelet:
Blood Chemistry: Hepatosplenomeg 68,000/cumm
Thrombocytop
SGOT: 558.0 aly
U/L(Up to 46) enia Signs/
symptoms:
Signs/ symptoms: Dengue Hemorrhagic Red sclera in
>Abdominal pain
with 5/10 pain
Fever both eyes
Petechiae
scale as
verbalized. Increase number and size of
Signs/
the pores in the capillaries
symptoms:
which leads to a leakage of +1 Bipedal
fluid from the blood to the edema; weak
interstitial fluid (capillary bounding pulse
Signs/ symptoms:
leakage) of the different
Profuse non-productive
cough with white
sputum with blood Signs/ symptoms:
spots noted; shallow & Abdominal distention
rapid respirations of Pleural Ascite with abdominal girth of
35cpm; crackles/rales effusion s 93cm (36.6 inches);
hypoactive bowel
sounds of 2/min
Diagnostic:
Ultrasound: Diagnostic:
Conclusion: Ultrasound:
Minimal bilateral Conclusion:
pleural effusion. Recovery Complications: Moderate
Intense bleeding ascites
Pulmonary Edema
Shock
Very low blood
pressure
Liver cirrhosis
Death
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Legend:

- Pathophsiology

- Medications - Signs and symptoms

- Diagnostic exams - Complications

- Interventions - Early signs