Human Molecular Genetics Bio 4560B

Instructor: Dr. Mike Grbic e-mail: mgrbic@uwo.ca

TA: Maja Milojevic : mmiloje2@uwo.ca

Office: WSC 342

Office hours: Tuesday&Thursday 9:30-10:30

Lectures: Tuesday&Thursday 8:30-9:30

Venue: BGS 1056

Book: Human Molecular genetics 4 Ed. Strachan&Read

Lectures:

1) Thursday Jan. 5. Tuesday Jan. 10. Human Molecular Biology: Introduction :

Why is human genetics important? The genetics of sexual selection

2) Tuesday Jan. 10. Human genome project and organization of the human genome I
p.256-294

3) Thursday Jan. 12. Human genome project and organization of the human genome
II p.256-294

4) Tuesday Jan. 17. Studying the gene function in post genomic era p. 382-404

5) Thursday Jan. 19. Comparative Genomics and Evolution of Human genome I p.

297-339

6) Tuesday Jan. 24. Comparative Genomics and Evolution of Human genome II p.

297-339

7) Thursday Jan. 26. Human gene expression I p. 347-378

8) Tuesday Jan. 31. Human gene expression II p.347-378

9) Thursday Feb. 2. Human Genetic variability and its consequences I p. 406-438

10) Tuesday Feb. 7. Human Genetic variability and its consequences II p. 406-438
11) Thursday Feb. 9. Identification of human disease genes and susceptibility factors I
p. 498-535

12) Tuesday Feb. 14. Identification of human disease genes and susceptibility factors
II p. 498-535

13) Thursday Feb. 16. In class first mid-term (30% grade before March 1)

Tuesday Feb. 21. Reading week

Thursday Feb. 23. Reading week

14) Tuesday Feb. 28. Genetic testing of individuals I p. 569-601

15) Thursday Mar. 2. Genetic testing of individuals II p. 569-601

16) Tuesday Mar. 7. Pharmacogenetics, personalized medicine and population

screening I p. 606-637.

17) Thursday Mar. 9. Pharmacogenetics, personalized medicine and population

screening II p. 606-637.

18) Tuesday Mar. 14. Cancer genetics I p. 538-567

19) Thursday Mar. 16. Cancer genetics II p. 538-567

20) Tuesday Mar. 21. Genetic approaches to treating disease I p. 678-716

21) Thursday Mar. 23. Genetic approaches to treating disease II p. 678-716

22) Tuesday Mar. 28 In class second midterm (30% grade)

23) Thursday Mar. 30. Genetic manipulation of animals for modeling diseases and
investigating gene function I p. 640-672

24) Tuesday April. 4. Genetic manipulation of animals for modeling diseases and
investigating gene function II p. 640-672

25) Thursday April. 6. Last lecture and providing take home final exam

Take home exam due: April 18th (to be e-mailed to TA Maja Milojevic:
mmiloje2@uwo.ca and cc-d to mgrbic@uwo.ca)

Evaluation: 2 in class midterms (30% each), Take home final exam 40%