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Karyl Cristine M.

Locsin BSN4-E Drug Study Name of drug Generic name: • Celecoxib Brand name: • Celebrex Classification: • Non-steroidal Antiinflammatory dosage/route/freq. 200 mg 1 cap p.o BID Mode of Action Thought to inhibit prostaglandin synthesis, impending cyclooxygenase-2 (COX-2), to produce antiinflammatory,analg esic and anti-pyretic effects. Indication To relive signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and adjunctive treatment for familial adenomatous polyposis to reduce the number of adenomatous colorectal polyps. Contraindications Patients hypersensitiv e to drug, sulfonamides , aspirin, or other NSAIDs. • Those w/ severe hepatic impairment • Pregnancy in 3rd trimester. Use cautiously in patients with history of ulcers or GI bleeding. • Adverse Reaction CNS : headache, dizziness, insomnia CV : Hypertension, peripheral edema EENT : pharyngitis, rhinitis, sinusitis GI: abd. Pain, diarrhea, dyspepsia, flatulence, nausea. Metabolic : hyperchloremia Respi. : Upper Respi Tract Infection Skin: erythema multiforme, exfoliative dermatitis, StevensJohnson Syndrome Nursing responsibilities • Watch for signs and symptoms of overt and occult bleeding. • Drug maybe hepatotoxic: watch for s/s of liver toxicity • Drug can be given w/out regard to meals, but food may decrease GI upset. • Assess patient for CV risk factors before therapy. • Watch for possibility of seizures when large doses are administered to elderly patients or to patients with

Generic Name: • Cloxacillin Sodium Brand Name: • Cloxacillin Classification: • Antiinfective;anti biotic

500 mg 1 cap p.o q6

interferes with the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins, thus inhibiting the crosslinking needed to from a stable

Cloxacillin is effective against Penicillinase producing Staphylococcus. It also acts against Strep Pyogenes,Strep Viridans, Strep

contraindicated in patients with a history of allergic reactions to penicillins use with caution in patients with a history of serious allergic reactions to

Hypersensitivity Gastrointestinal: nausea, vomiting, diarrhea Vaginitis

bacterial cell wall. This leads to autolysis of the bacteria by autolysins.

Pneumonia.

cephalosporins •

renal impairment monitor renal, hepatic, and hematopoeti c functions with prolonged usage

Generic Name: • Mefenamic Acid Brand Name: • Mefenax Classification: • NSAID

500mg 1 cap p.o q6h

Reversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and antiinflammatory properties.

used to treat mild to moderate pain, including menstrual discomfort. While the exact mechanism of mefenamic acid is unknown, experts believe the medication, like other NSAIDs, works at least in part by inhibiting prostaglandin, a substance that promotes inflammation, pain and fever.

Hypersensitivity to mefenamic acid, aspirin, other NSAIDs, or any component of the formulation; perioperative pain in the setting of coronary artery bypass graft (CABG) surgery; active ulceration or chronic inflammation of the GI tract; renal disease

Central nervous system: Headache, nervousness, dizziness Dermatologic: Itching, rash Endocrine & metabolic: Fluid retention Gastrointestinal: Abdominal cramps, heartburn, indigestion, nausea , vomiting, diarrhea , constipation , abdominal distress/cramping/p ain , dyspepsia , flatulence , gastric or duodenal ulcer with bleeding or perforation , gastritis. Hematologic: Bleeding

1.If patient have had a stomach ulcer or bleeding, tell healthcare provider. 2. Instruct patient to avoid alcohol (includes wine, beer, and liquor) when taking this medicine since it can cause increases in stomach irritation. 3. Use caution if the patient has a weakened heart. It may cause increased shortness of breath or weight gain. Then recommend to talk with healthcare provider or its own physician. 4. Avoid aspirin, aspirin-containing products, other pain medicines, other blood thinners (warfarin, ticlopidine, clopidogrel) 5. If patient is allergic to any medicine, especially aspirin, or have asthma. Make sure to tell about the allergy and how it affected the patient

by consulting its attending physician.